MCID: PRL016
MIFTS: 19

Proliferative Type Fibrocystic Change of Breast

Categories: Cancer diseases

Aliases & Classifications for Proliferative Type Fibrocystic Change of Breast

MalaCards integrated aliases for Proliferative Type Fibrocystic Change of Breast:

Name: Proliferative Type Fibrocystic Change of Breast 12 15
Fibrocystic Disease, Proliferative Type with Atypia 12
Fibrocystic Change, Proliferative Type with Atypia 12
Proliferating Lesion of the Breast Without Atypia 12
Proliferating Lesion of Breast Without Atypia 12
Breast Fibrocystic Change, Proliferative Type 70
Proliferative Fibrocystic Change 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3274
NCIt 50 C8365
SNOMED-CT 67 35813005
UMLS 70 C0334056 C1332629

Summaries for Proliferative Type Fibrocystic Change of Breast

Disease Ontology : 12 A breast fibrocystic disease that is characterized by the presence of epithelial cell hyperplasia and the absence of epithelial atypia.

MalaCards based summary : Proliferative Type Fibrocystic Change of Breast, also known as fibrocystic disease, proliferative type with atypia, is related to non-proliferative fibrocystic change of the breast and sclerosing adenosis of breast. An important gene associated with Proliferative Type Fibrocystic Change of Breast is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are Phenylalanine metabolism and Cyclophosphamide Pathway, Pharmacodynamics. Affiliated tissues include breast.

Related Diseases for Proliferative Type Fibrocystic Change of Breast

Diseases related to Proliferative Type Fibrocystic Change of Breast via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 non-proliferative fibrocystic change of the breast 31.1 TBC1D9 SERPINA3 EXTL1 DNAJC12
2 sclerosing adenosis of breast 11.4
3 fibrosclerosis of breast 11.3
4 apocrine adenosis of breast 11.3
5 skull base cancer 9.8 SERPINA3 EXTL1
6 skull base meningioma 9.8 SERPINA3 EXTL1
7 focal dermal hypoplasia 9.7 ADH6 ADH5

Graphical network of the top 20 diseases related to Proliferative Type Fibrocystic Change of Breast:



Diseases related to Proliferative Type Fibrocystic Change of Breast

Symptoms & Phenotypes for Proliferative Type Fibrocystic Change of Breast

Drugs & Therapeutics for Proliferative Type Fibrocystic Change of Breast

Search Clinical Trials , NIH Clinical Center for Proliferative Type Fibrocystic Change of Breast

Genetic Tests for Proliferative Type Fibrocystic Change of Breast

Anatomical Context for Proliferative Type Fibrocystic Change of Breast

MalaCards organs/tissues related to Proliferative Type Fibrocystic Change of Breast:

40
Breast

Publications for Proliferative Type Fibrocystic Change of Breast

Articles related to Proliferative Type Fibrocystic Change of Breast:

# Title Authors PMID Year
1
An analysis of breast cancer risk in women with single, multiple, and atypical papilloma. 61
16723843 2006
2
Atypical hyperplasia, proliferative fibrocystic change, and exogenous hormone use. 61
11602905 2001
3
Effectiveness of dynamic MRI for diagnosing pericicatricial minimal residual breast cancer following excisional biopsy. 61
11673001 2001
4
Breast cancer in dense breast: detection with contrast-enhanced dynamic MR imaging. 61
10739554 2000
5
Subclassification of benign breast disease by fine needle aspiration cytology. Comparison of cytologic and histologic findings in 265 palpable breast masses. 61
8147200 1994
6
Radiographic microcalcification and parenchymal patterns as indicators of histologic "high-risk" benign breast disease. 61
2208027 1990
7
Benign proliferative disorders of the breast. 61
2219974 1990

Variations for Proliferative Type Fibrocystic Change of Breast

Expression for Proliferative Type Fibrocystic Change of Breast

Search GEO for disease gene expression data for Proliferative Type Fibrocystic Change of Breast.

Pathways for Proliferative Type Fibrocystic Change of Breast

Pathways related to Proliferative Type Fibrocystic Change of Breast according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.86 ADH6 ADH5
2
Show member pathways
10.11 ADH6 ADH5

GO Terms for Proliferative Type Fibrocystic Change of Breast

Biological processes related to Proliferative Type Fibrocystic Change of Breast according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ethanol oxidation GO:0006069 8.62 ADH6 ADH5

Molecular functions related to Proliferative Type Fibrocystic Change of Breast according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 alcohol dehydrogenase (NAD) activity GO:0004022 8.96 ADH6 ADH5
2 alcohol dehydrogenase activity, zinc-dependent GO:0004024 8.62 ADH6 ADH5

Sources for Proliferative Type Fibrocystic Change of Breast

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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