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MCID: PRL017
MIFTS: 47

Prolymphocytic Leukemia

Categories: Blood diseases, Cancer diseases, Immune diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Prolymphocytic Leukemia

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MalaCards integrated aliases for Prolymphocytic Leukemia:

Name: Prolymphocytic Leukemia 12 74 15 71
Leukemia, Prolymphocytic 43
Leukemia Prolymphocytic 54

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Immune diseases Blood diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:1039
MeSH 43 D015463
NCIt 49 C3181
SNOMED-CT 67 128923008
UMLS 71 C0023486
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Summaries for Prolymphocytic Leukemia

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MalaCards based summary : Prolymphocytic Leukemia, also known as leukemia, prolymphocytic, is related to b cell prolymphocytic leukemia and t-cell prolymphocytic leukemia. An important gene associated with Prolymphocytic Leukemia is MTCP1 (Mature T Cell Proliferation 1), and among its related pathways/superpathways are IL-2 Pathway and Endometrial cancer. The drugs Cefepime and Levofloxacin have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and bone, and related phenotypes are Reduced mammosphere formation and Decreased human cytomegalovirus (HCMV) strain AD169 replication

Wikipedia : 74 Prolymphocytic leukemia is divided into two types according to the kind of cell involved: B-cell... more...

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Related Diseases for Prolymphocytic Leukemia

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Diseases related to Prolymphocytic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 250)
# Related Disease Score Top Affiliating Genes
1 b cell prolymphocytic leukemia 33.5 ZAP70 TP53 MYC FCER2 CD5 CD38
2 t-cell prolymphocytic leukemia 33.0 TCL1A MYC MTCP1 JAK3 JAK1 HLA-S
3 anemia, autoimmune hemolytic 30.6 ZAP70 CD52 CD5 CD19
4 adult t-cell leukemia 30.5 TP53 MYC JAK3 CD7
5 adult lymphoma 30.5 MYC CD5 CD19
6 ataxia-telangiectasia 30.4 TP53 TCL1A MTCP1 ATM ABL1
7 t-cell lymphoblastic leukemia/lymphoma 30.4 ZAP70 TCL1A MYC MTCP1 CD7 CCND1
8 pancytopenia 30.3 TP53 CD7 CD5 CD19
9 rare tumor 30.2 FCER2 CR2
10 plasma cell leukemia 30.1 MYC CD38 CCND1
11 lymphoblastic lymphoma 30.1 TP53 MYC CD7 CD5
12 leukemia 30.1 TP53 TCL1A MYC MTCP1 JAK3 JAK1
13 autoimmune lymphoproliferative syndrome, type v 30.0 CD52 CD5
14 precursor t-cell acute lymphoblastic leukemia 30.0 TCL1A MYC CD7 ABL1
15 hairy cell leukemia 30.0 TP53 CD52 CD5 CD38 CCND1 ADA
16 leukemia, chronic lymphocytic 2 30.0 ZAP70 FCER2 CD5 CD38 ATM
17 nijmegen breakage syndrome 30.0 TP53 MYC ATM
18 plasmacytoma 29.9 MYC CD5 CD38 CCND1
19 richter's syndrome 29.9 ZAP70 TP53 MYC CD5 CD38 ATM
20 t-cell adult acute lymphocytic leukemia 29.8 TP53 JAK3 CD7 CD52 CD5
21 sezary's disease 29.6 TP53 MYC JAK3 CD7 CD52 CD5
22 diffuse large b-cell lymphoma 29.5 TP53 TCL1A MYC CD5 CD38 CD19
23 peripheral t-cell lymphoma 29.4 TP53 TCL1A CD5 CD38 CD19 CCND1
24 mantle cell lymphoma 29.3 TP53 TCL1A MYC CD52 CD5 CD19
25 cll/sll 29.0 ZAP70 TP53 CD5 CD38 CD19 CCND1
26 lymphoma 28.9 TP53 TCL1A MYC CR2 CD5 CD38
27 lymphoma, mucosa-associated lymphoid type 28.8 ZAP70 TP53 MYC CR2 CD5 CD19
28 leukemia, chronic myeloid 28.7 TP53 MYC CD38 CD19 CCND1 ADA
29 b-cell lymphoma 28.6 ZAP70 TP53 TCL1A MYC FCER2 CR2
30 leukemia, acute lymphoblastic 28.0 ZAP70 TP53 MYC JAK3 JAK1 CD7
31 leukemia, acute myeloid 27.8 TP53 MYC JAK3 JAK1 CD7 CD5
32 burkitt lymphoma 27.6 TP53 TCL1A MYC JAK3 JAK1 FCER2
33 leukemia, chronic lymphocytic 27.5 ZAP70 TP53 TCL1A MYC FCER2 CR2
34 lymphoma, non-hodgkin, familial 27.2 TP53 TCL1A MYC FCER2 CR2 CD7
35 splenic manifestation of prolymphocytic leukemia 12.4
36 splenomegaly 10.8
37 leukemia, t-cell, chronic 10.7
38 chromosomal triplication 10.6
39 lymphoproliferative syndrome 10.6
40 lymphoma aids related 10.6 TCL1A MYC
41 endocrine exophthalmos 10.5 CD5 ATM
42 appendix lymphoma 10.5 MYC CD5
43 thrombocytopenia 10.5
44 telangiectasis 10.4
45 listeria meningitis 10.4 CD52 ADA
46 parapsoriasis 10.4 CD7 CD5
47 ataxia and polyneuropathy, adult-onset 10.4
48 immunodeficiency 19 10.4 ZAP70 ADA
49 anal carcinoma in situ 10.4 TP53 MYC
50 refractory hematologic cancer 10.4 CD38 CD19

Graphical network of the top 20 diseases related to Prolymphocytic Leukemia:



Diseases related to Prolymphocytic Leukemia
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Symptoms & Phenotypes for Prolymphocytic Leukemia

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GenomeRNAi Phenotypes related to Prolymphocytic Leukemia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.23 ATM CCND1 CD5 CD52 CD7 JAK3
2 Decreased human cytomegalovirus (HCMV) strain AD169 replication GR00248-A 9.13 ATM JAK3 ZAP70

MGI Mouse Phenotypes related to Prolymphocytic Leukemia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.18 ABCB4 ABL1 ADA ATM CCND1 CD19
2 hematopoietic system MP:0005397 10.16 ABCB4 ABL1 ADA ATM CCND1 CD19
3 cardiovascular system MP:0005385 10.13 ABCB4 ABL1 ADA ATM CCND1 CD19
4 endocrine/exocrine gland MP:0005379 10.1 ABCB4 ABL1 ADA ATM CCND1 CD38
5 immune system MP:0005387 10.06 ABCB4 ABL1 ADA ATM CCND1 CD19
6 digestive/alimentary MP:0005381 10.02 ABCB4 ABL1 ADA CCND1 CD19 FCER2
7 liver/biliary system MP:0005370 9.5 ABCB4 ABL1 ADA CD19 JAK1 MYC
8 normal MP:0002873 9.28 ABL1 ADA CCND1 CD19 CD5 JAK1
Sources

Drugs & Therapeutics for Prolymphocytic Leukemia

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Drugs for Prolymphocytic Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 248)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cefepime Approved, Investigational Phase 3 88040-23-7 5479537
2
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
3
Ofloxacin Approved Phase 3 82419-36-1 4583
4
Ketamine Approved, Vet_approved Phase 3 6740-88-1 3821
5
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
6
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
7
Busulfan Approved, Investigational Phase 2, Phase 3 55-98-1 2478
8
Etoposide Approved Phase 2, Phase 3 33419-42-0 36462
9
Melphalan Approved Phase 2, Phase 3 148-82-3 460612 4053
10
Ondansetron Approved Phase 3 99614-02-5 4595
11
Darbepoetin alfa Approved, Investigational Phase 3 11096-26-7, 209810-58-2
12
Caspofungin Approved Phase 3 162808-62-0, 179463-17-3 2826718 468682
13
Thiotepa Approved, Investigational Phase 2, Phase 3 52-24-4 5453
14
Cladribine Approved, Investigational Phase 3 4291-63-8 20279
15
Dalteparin Approved Phase 3 9005-49-6
16
Tinzaparin Approved Phase 3 9041-08-1, 9005-49-6 25244225
17
Carboplatin Approved Phase 2, Phase 3 41575-94-4 10339178 38904 498142
18
Dextromethorphan Approved Phase 3 125-71-3 5360696 5362449
19
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
20
Iron Approved, Experimental Phase 3 15438-31-0, 7439-89-6 27284 23925
21
Amphotericin B Approved, Investigational Phase 3 1397-89-3 5280965 14956
22
Ginseng Approved, Investigational, Nutraceutical Phase 3 50647-08-0
23 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
24 Anesthetics, Dissociative Phase 3
25 Anti-Bacterial Agents Phase 3
26 Anti-Infective Agents Phase 3
27 Antifungal Agents Phase 3
28 Dermatologic Agents Phase 3
29 Analgesics Phase 3
30 Etoposide phosphate Phase 2, Phase 3
31 Cola Phase 3
32 Liver Extracts Phase 3
33 Gastrointestinal Agents Phase 3
34 Antiemetics Phase 3
35 Neurotransmitter Agents Phase 3
36 Analgesics, Opioid Phase 3
37 Psychotropic Drugs Phase 3
38 Anti-Anxiety Agents Phase 3
39 Antipsychotic Agents Phase 3
40 Hematinics Phase 3
41 Epoetin alfa Phase 3 113427-24-0
42 Fibrinolytic Agents Phase 3
43 Antiprotozoal Agents Phase 3
44 Antiparasitic Agents Phase 3
45 Heparin, Low-Molecular-Weight Phase 3
46 Excitatory Amino Acid Antagonists Phase 3
47 Narcotics Phase 3
48 Anesthetics Phase 3
49 Anesthetics, General Phase 3
50 Anesthetics, Intravenous Phase 3

Interventional clinical trials:

(show top 50) (show all 207)
# Name Status NCT ID Phase Drugs
1 Multicenter, Double-Blind, Randomized Study to Compare the Safety and Efficacy of Levofloxacin With That of Cefepime in the Treatment of Fever and Neutropenia - Phase IIIB Unknown status NCT00020865 Phase 3 cefepime hydrochloride;levofloxacin
2 A Randomized Double-Blind Controlled Trial of Ketamine Versus Placebo in Conjunction With Best Pain Management in Neuropathic Pain in Cancer Patients Unknown status NCT01316744 Phase 3 ketamine hydrochloride
3 A Randomized, Open-Label, Multicenter Study Of Darbepoetin Alfa Administered Once Every Two Weeks (Q2W) Compared With rHuEPO Administered Once Every Week (QW) For The Treatment Of Anemia In Subjects With Non-Myeloid Malignancies Receiving Multiple Chemotherapy Completed NCT00070382 Phase 3 darbepoetin alfa;epoetin alfa
4 A Randomized Phase III Study to Determine the Most Promising Postgrafting Immunosuppression for Prevention of Acute GVHD After Unrelated Donor Hematopoietic Cell Transplantation Using Nonmyeloablative Conditioning for Patients With Hematologic Malignancies: A Multi-center Trial Completed NCT01231412 Phase 3 Cyclosporine;Fludarabine Phosphate;Mycophenolate Mofetil;Sirolimus
5 Daily Versus Weekly Administration of 2-Chlorodeoxyadenosine (CDA) in Patients With Hairy Cell Leukemia Completed NCT00003746 Phase 3 2-chlorodeoxyadenosine (CDA) daily;2-chlorodeoxyadenosine weekly
6 Phase III, Randomized, Double-Blind, Placebo-Controlled Crossover Trial of Ondansetron in the Control of Chronic Nausea and Vomiting Not Due to Antineoplastic Therapy in Patients With Advanced Cancer Completed NCT00006348 Phase 3 ondansetron
7 A Phase III Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effects of Fragmin (5,000 IU Subcutaneously) in Preventing Catheter-Related Complications When Given Daily to Cancer Patients With Central Venous Catheters Completed NCT00006083 Phase 3 Fragmin
8 Allogeneic Blood or Marrow Transplantation for Hematologic Malignancy and Aplastic Anemia Completed NCT00003816 Phase 2, Phase 3 busulfan;carboplatin;cyclophosphamide;etoposide;fludarabine phosphate;melphalan;thiotepa
9 A Phase III Double-Blind Equivalence Study of Two Different Formulations of Slow-Release Morphine Followed by a Randomization Between Dextromethorphan or Placebo Plus Statex SR for Chronic Cancer Pain Relief in Terminally Ill Patients Completed NCT00003687 Phase 3 dextromethorphan hydrobromide;morphine sulfate
10 A Phase III, Randomized Study of the Effects of Parenteral Iron, Oral Iron, or No Iron Supplementation on the Erythropoietic Response to Darbepoetin Alfa for Cancer Patients With Chemotherapy-Associated Anemia Completed NCT00661999 Phase 3 sodium ferric gluconate complex in sucrose
11 Preparatory Aid to Improve Decision Making About Cancer Clinical Trials (PRE-ACT) Completed NCT00750009 Phase 3
12 A Strategic Study to Determine the Optimal Moment to Initiate Systemic Antifungal Therapy With Ambisome in Granulocytopenic Cancer Patients With Unexplained Fever Refractory to Empirical Antibacterials Completed NCT00003938 Phase 3 liposomal amphotericin B
13 A Multicenter, Double-Blind, Randomized, Comparative Study To Evaluate The Safety, Tolerability, And Efficacy Of MK-0991 Versus (Amphotericin B) Liposome For Injection As Empirical Therapy In Patients With Persistent Fever And Neutropenia Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
14 The Use of American Ginseng (Panax Quinquefolius) to Improve Cancer-Related Fatigue: A Randomized, Double-Blind, Placebo-Controlled Phase III Study Completed NCT00719563 Phase 3 American ginseng
15 Phase III Randomized Trial of an Opioid Titration Order Sheet Compared to Standard of Care in Patients With Cancer Related Pain. Completed NCT00666211 Phase 3
16 A Randomized, Double-blind, Placebo-controlled Multi-center Study to Evaluate the Safety and Efficacy of Fentanyl Sublingual Spray (Fentanyl SL Spray) for the Treatment of Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
17 Study Evaluating the Efficacy and Safety of PCAR-019 in CD19 Positive Relapsed or Refractory Leukemia and Lymphoma Unknown status NCT02819583 Phase 1, Phase 2
18 Study Evaluating the Efficacy and Safety of PCAR-019 in CD19 Positive Relapsed or Refractory Leukemia and Lymphoma Unknown status NCT02851589 Phase 1, Phase 2
19 PCAR-119 Bridge Immunotherapy Prior to Stem Cell Transplant in Treating Patients With CD19 Positive Relapsed or Refractory Leukemia and Lymphoma Unknown status NCT02892695 Phase 1, Phase 2
20 Chimeric Antigen Receptor-Modified pNK Cells for CD7 Positive Relapsed or Refractory Leukemia and Lymphoma Unknown status NCT02742727 Phase 1, Phase 2
21 Pilot Study of Redirected Autologous T Cells Transduced to Express A CD20-Specific Chimeric Immunoreceptor in Patient With Chemotherapy Resistant or Refractory CD20+ Leukemia and Lymphoma Unknown status NCT01735604 Phase 1, Phase 2
22 A Pilot Study to Assess the Feasibility of Unrelated Umbilical Cord Blood Transplantation With Coinfusion of Third-party Mesenchymal Stem Cells After Myeloablative or Nonmyeloablative Conditioning in Patients With Hematological Malignancies Unknown status NCT01092026 Phase 1, Phase 2
23 Allogeneic Hematopoietic Stem Cell Transplantation With Nonmyeloablative Conditioning for Patients With Chronic Lymphocytic Leukemia - A Multi-center Trial Completed NCT00060424 Phase 2 Cyclosporine;Fludarabine Phosphate;Mycophenolate Mofetil
24 Phase II Trial of Combined Immunochemotherapy With Fludarabine, Mitoxantrone, Cyclophosphamide and Alemtuzumab (FMC-Alemtuzumab) in Patients With Previously Treated or Untreated T-Prolymphocytic Leukemia Completed NCT01186640 Phase 2 Fludarabine, Mitoxantrone, Cyclophosphamide and Alemtuzumab;Alemtuzumab
25 Consolidation With Campath-1H After FMC Induction in Patients With T-cell Chronic Lymphocytic Leukemia Completed NCT00278213 Phase 2 cyclophosphamide;fludarabine phosphate;mitoxantrone hydrochloride
26 A Phase II Trial of Post-Transplant Cyclophosphamide and Sirolimus for Graft-versus-host Disease (GVHD) Prophylaxis Following Reduced Intensity Allogeneic Hematopoietic Stem Cell Transplantation Completed NCT01244906 Phase 2
27 A Multicenter, Open-label, Single Arm Study of Weekly Alvocidib in Patients With Previously Treated B-Cell Chronic Lymphocytic Leukemia (CLL) or Prolymphocytic Leukemia (PLL) Arising From CLL Completed NCT00464633 Phase 2 alvocidib
28 A Phase I/II Study of Autologous Stem Cell Transplantation Followed by Nonmyeloablative Allogeneic Stem Cell Transplantation for Patients With Relapsed or Refractory Lymphoma - A Multi-center Trial Completed NCT00005803 Phase 1, Phase 2 Carmustine;Cyclophosphamide;Cyclosporine;Cytarabine;Etoposide;Fludarabine Phosphate;Melphalan;Mycophenolate Mofetil
29 Phase 1b/2 Study of Dinaciclib (SCH 727965) and Ofatumumab in Relapsed and Refractory CLL/SLL/B-PLL Completed NCT01515176 Phase 1, Phase 2 Dinaciclib
30 Sequential Autologous HCT / Nonmyeloablative Allogeneic HCT Using Related, HLA-Haploidentical Donors for Patients With High-Risk Lymphoma, Multiple Myeloma, or Chronic Lymphocytic Leukemia Completed NCT01008462 Phase 2 Carmustine;Cyclophosphamide;Cytarabine;Etoposide;Fludarabine Phosphate;Melphalan;Mycophenolate Mofetil;Tacrolimus
31 A Phase II Study to Assess Immunosuppression With Sirolimus Combined With Cyclosporine (CSP) and Mycophenolate Mofetil (MMF) for Prevention of Acute GVHD After Non-Myeloablative HLA Class I or II Mismatched Donor Hematopoietic Cell Transplantation- A Multi-Center Trial Completed NCT01251575 Phase 2 Cyclosporine;Fludarabine Phosphate;Mycophenolate Mofetil;Sirolimus
32 Minimal Ablation and Cellular Immune Therapy of Chronic Lymphocytic Leukemia, Prolymphocytic Leukemia, Low-Grade Non-Hodgkin's Lymphoma, and Mantle Cell Lymphoma With Allogeneic Donor Stem Cells Completed NCT00006252 Phase 2 fludarabine phosphate;Cyclophosphamide;G-CSF
33 A Phase I Phase II Two-Step Study of the Oral Gold Compound Auranofin in Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL)/ Prolymphocytic Lymphoma (PLL) Completed NCT01419691 Phase 2 auranofin
34 Umbilical Cord Blood (UCB) Allogeneic Stem Cell Transplant for Hematologic Malignancies Completed NCT01093586 Phase 2 busulfan;cyclophosphamide;anti-thymocyte globulin;methylprednisolone;cyclosporine;mycophenolate mofetil
35 Nonmyeloablative Conditioning With Pre- and Post-Transplant Rituximab Followed by Related or Unrelated Donor Hematopoietic Cell Transplantation for Patients With Advanced Chronic Lymphocytic Leukemia: A Multi-Center Trial Completed NCT00104858 Phase 2 Cyclosporine;Fludarabine Phosphate;Mycophenolate Mofetil
36 Non-Myeloablative Allogeneic Hematopoietic Cell Transplantation For Patients With Disease Relapse Or Myelodysplasia After Prior Autologous Transplantation Completed NCT00053196 Phase 2 busulfan;fludarabine phosphate;methotrexate;mycophenolate mofetil;tacrolimus;allopurinol
37 Assessment of Early and Standard Intervention With Procrit® (Epoetin Alfa) 120,000 Units Once Every Three Weeks (Q3W) in Patients With Cancer Receiving Chemotherapy Completed NCT00255749 Phase 2
38 Phase I/II Study of Subcutaneously Administered Veltuzumab (hA20) in Patients With CD20+ Non-Hodgkin's Lymphoma or Chronic Lymphocytic Leukemia Completed NCT00546793 Phase 1, Phase 2
39 A Multicenter, Open, Phase II Study to Estimate the Activity and Safety of Caspofungin (CASP) in the First-Line Treatment of Probable and Proven Invasive Aspergillosis (IA) in Patients With Hematological Malignancies (HM) or Recipients of Autologous Haematopoietic Stem Cell Transplantation and Those With Allogeneic Haematopoietic Stem Cell Transplantation (HSCT) Completed NCT00110045 Phase 2 caspofungin acetate
40 Trial of Immune Reconstitution With Activated T-Cells in Patients With Chronic Lymphocytic Leukemia (CLL) Completed NCT02530515 Phase 2
41 A Multi-Center Study of Nonmyeloablative Conditioning With TBI or Fludarabine/TBI for HLA-matched Related Hematopoietic Cell Transplantation for Treatment of Hematologic Malignancies With Post Grafting Immunosuppression With Tacrolimus and Mycophenolate Mofetil Completed NCT00089011 Phase 2 fludarabine phosphate;mycophenolate mofetil;tacrolimus
42 Donor Statin Treatment for Prevention of Severe Acute GVHD After Nonmyeloablative Hematopoietic Cell Transplantation Completed NCT01527045 Phase 2 Atorvastatin Calcium;Cyclosporine;Fludarabine Phosphate;Mycophenolate Mofetil
43 Transplantation of Unrelated Umbilical Cord Blood for Patients With Hematological Diseases With Cyclophosphamide/Fludarabine/Total Body Irradiation Myeloablative Preparative Regimen Completed NCT00309842 Phase 2 cyclophosphamide;cyclosporine;fludarabine phosphate;mycophenolate mofetil
44 An Open-label, Phase 1b/2, Safety and Efficacy Study of the Bruton's Tyrosine Kinase (Btk) Inhibitor, PCI-32765, and Ofatumumab in Subjects With Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma and Prolymphocytic Leukemia Completed NCT01217749 Phase 1, Phase 2 PCI-32765;ofatumumab
45 Phase II Trial With Correlative Laboratory Studies of Single Agent Irinotecan (Camptosar CPT-11) in Newly Diagnosed and Relapsed Indolent Lymphoproliferative Malignancies Completed NCT00005626 Phase 2 Irinotecan
46 A Phase I-II Study of Oxaliplatin, Fludarabine, Cytarabine and Rituximab in Patients With Richter's Transformation, Prolymphocytic Leukemia or Refractory/Relapsed B-Cell Chronic Lymphocytic Leukemia Completed NCT00452374 Phase 1, Phase 2 Cytarabine;Fludarabine;Oxaliplatin;Rituximab
47 A Phase I-II Study of Oxaliplatin, Fludarabine, Cytarabine, and Rituximab in Patients With Richter's Transformation, Prolymphocytic Leukemia, Aggressive, Relapsed or Refractory B-Cell Chronic Lymphocytic Leukemia Completed NCT00472849 Phase 1, Phase 2 Oxaliplatin;Fludarabine;Cytarabine;Rituximab;Pegfilgrastim
48 Therapy of Chronic Lymphocytic Leukemia With Dasatinib (BMS-354825) Completed NCT00364286 Phase 2 Dasatinib (BMS-354825)
49 Phase II Multicenter Trial Of Pentostatin and Rituximab In Patients With Previously Treated and Untreated Low Grade B-Cell Non-Hodgkin's Lymphoma (NHL) Including Chronic Lymphocytic Leukemia (CLL) Completed NCT00026351 Phase 2 pentostatin
50 OUTPATIENT SUBCUTANEOUS IL-2 AND ALPHA INTERFERON IN THE MANAGEMENT OF METASTATIC CANCER Completed NCT00002504 Phase 2

Search NIH Clinical Center for Prolymphocytic Leukemia

Cochrane evidence based reviews: leukemia, prolymphocytic

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Genetic Tests for Prolymphocytic Leukemia

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Anatomical Context for Prolymphocytic Leukemia

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MalaCards organs/tissues related to Prolymphocytic Leukemia:

40
T Cells, B Cells, Bone, Bone Marrow, Myeloid, Liver, Nk Cells
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Publications for Prolymphocytic Leukemia

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Articles related to Prolymphocytic Leukemia:

(show top 50) (show all 832)
# Title Authors PMID Year
1
[CD5-positive B-cell prolymphocytic leukemia]. 54 61
20134145 2010
2
Molecular allelokaryotyping of T-cell prolymphocytic leukemia cells with high density single nucleotide polymorphism arrays identifies novel common genomic lesions and acquired uniparental disomy. 61 54
19278963 2009
3
Haploinsufficiency of CDKN1B contributes to leukemogenesis in T-cell prolymphocytic leukemia. 61 54
18073348 2008
4
High TCL1 expression and intact T-cell receptor signaling define a hyperproliferative subset of T-cell prolymphocytic leukemia. 54 61
17890451 2008
5
IgVH genes mutation and usage, ZAP-70 and CD38 expression provide new insights on B-cell prolymphocytic leukemia (B-PLL). 61 54
16642047 2006
6
D cyclins in CD5+ B-cell lymphoproliferative disorders: cyclin D1 and cyclin D2 identify diagnostic groups and cyclin D1 correlates with ZAP-70 expression in chronic lymphocytic leukemia. 61 54
16393687 2006
7
Inhibition of Akt kinase activity by a peptide spanning the betaA strand of the proto-oncogene TCL1. 61 54
15459205 2004
8
Immunohistochemical detection of ZAP-70 in 341 cases of non-Hodgkin and Hodgkin lymphoma. 61 54
15133473 2004
9
ATM mutations are associated with inactivation of the ARF-TP53 tumor suppressor pathway in diffuse large B-cell lymphoma. 61 54
12149228 2002
10
Breakpoints in the ataxia telangiectasia gene arise at the RGYW somatic hypermutation motif. 54 61
11821961 2002
11
Structure of murine Tcl1 at 2.5 A resolution and implications for the TCL oncogene family. 61 54
11679718 2001
12
TCL1 is activated by chromosomal rearrangement or by hypomethylation. 61 54
11241786 2001
13
Regulation of TCL1 expression in B- and T-cell lymphomas and reactive lymphoid tissues. 61 54
10786666 2000
14
Aberrant splicing of the ATM gene associated with shortening of the intronic mononucleotide tract in human colon tumor cell lines: a novel mutation target of microsatellite instability. 54 61
10738255 2000
15
Role of TCL1 and ALL1 in human leukemias and development. 54 61
10197596 1999
16
Transgenic mice for MTCP1 develop T-cell prolymphocytic leukemia. 54 61
9657733 1998
17
Ataxia-telangiectasia and T-cell leukemias: no evidence for somatic ATM mutation in sporadic T-ALL or for hypermethylation of the ATM-NPAT/E14 bidirectional promoter in T-PLL. 54 61
9622061 1998
18
Inactivation of the ATM gene in T-cell prolymphocytic leukemias. 54 61
9573030 1998
19
Solution structure of the recombinant human oncoprotein p13MTCP1. 54 61
9691281 1998
20
Crystal structure of p14TCL1, an oncogene product involved in T-cell prolymphocytic leukemia, reveals a novel beta-barrel topology. 61 54
9519406 1998
21
Alternative origin of p13MTCP1-encoding transcripts in mature T-cell proliferations with t(X;14) translocations. 54 61
9315101 1997
22
Perforin-positive leukemic cell infiltration in the aortic tissue of a patient with T-cell prolymphocytic leukemia. 61 54
8971584 1996
23
Expression of p13MTCP1 is restricted to mature T-cell proliferations with t(X;14) translocations. 54 61
8634440 1996
24
Overexpression of the PRAD1 oncogene in a patient with prolymphocytic leukemia with t(11;14)(q13;q32). 54 61
7497446 1995
25
B-cell prolymphocytic leukemia expressing CD13 antigen. 61 54
7524729 1994
26
Burkitt-like mutations in the c-myc gene locus in prolymphocytic leukemia. 61 54
8182948 1994
27
Cyclin D1 overexpression in non-Hodgkin's lymphoma with chromosome 11 bcl-1 rearrangement. 54 61
8172823 1994
28
Induction of apoptosis in CD4+ prolymphocytic leukemia by deoxyadenosine and 2'-deoxycoformycin. 61 54
1528066 1992
29
Expression of the mdr3 gene in prolymphocytic leukemia: association with cyclosporin-A-induced increase in drug accumulation. 54 61
2323839 1990
30
Purine metabolism enzymes and immunological phenotype in chronic B-cell malignancies: chronic lymphocytic leukemia, prolymphocytic leukemia and hairy cell leukemia. 54 61
2125699 1990
31
Hematologist-Level Classification of Mature B-Cell Neoplasm Using Deep Learning on Multiparameter Flow Cytometry Data. 61
32519455 2020
32
Epstein-Barr virus-positive diffuse large B-cell lymphoma after sustained remission of T-cell prolymphocytic leukemia with alemtuzumab. 61
31960738 2020
33
T-cell prolymphocytic leukemia: Review of an entity and its differential diagnostic considerations. 61
32543075 2020
34
Current understandings on T-cell prolymphocytic leukemia and its association with TCL1 proto-oncogene. 61
32247279 2020
35
Generalized pruritic dark papules in a patient with T-cell prolymphocytic leukemia - a clinicopathological challenge. 61
31515798 2020
36
What to Look Out for when Transplanting T-Cell Prolymphocytic Leukemia. 61
32369824 2020
37
T-Cell Prolymphocytic Leukemia: Long-Term Remissions Challenging! 61
32392564 2020
38
Initial treatment of B-cell prolymphocytic leukemia with ibrutinib. 61
31951033 2020
39
A Rare Association: Autoimmune Hemolytic Anemia With Indolent T-Cell Prolymphocytic Leukemia. 61
32523849 2020
40
Patterns of Late Relapse after Allogeneic Hematopoietic Stem Cell Transplantation in Patients with T-Cell Prolymphocytic Leukemia. 61
32259827 2020
41
Reconstruction of rearranged T-cell receptor loci by whole genome and transcriptome sequencing gives insights into the initial steps of T-cell prolymphocytic leukemia. 61
31677197 2020
42
Sensitizing the interdisciplinary team to desensitizations: An alemtuzumab case report. 61
31390960 2020
43
Advances and Perspectives in the Treatment of T-PLL. 61
32034661 2020
44
Pretransplant adaptive NKG2C+ NK cells protect against cytomegalovirus infection in kidney transplant recipients. 61
31612635 2020
45
B-cell prolymphocytic leukemia successfully treated with B-cell receptor antagonists, but resistant to venetoclax. 61
31713446 2020
46
Dual dependence on BCL2 and MCL1 in T-cell prolymphocytic leukemia. 61
32040552 2020
47
SynToxProfiler: An interactive analysis of drug combination synergy, toxicity and efficacy. 61
32012154 2020
48
First report of clinical response to venetoclax combination with pentostatin in T-cell-prolymphocytic leukemia (T-PLL). 61
31566032 2020
49
CHORIOCAPILLARIS FLOW VOIDS IN CRYPTOCOCCAL CHOROIDITIS USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY. 61
29373342 2020
50
Effective upfront treatment with low-dose ibrutinib for a patient with B cell prolymphocytic leukemia. 61
31965420 2020
Sources

Variations for Prolymphocytic Leukemia

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Expression for Prolymphocytic Leukemia

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Search GEO for disease gene expression data for Prolymphocytic Leukemia.
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Pathways for Prolymphocytic Leukemia

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Pathways related to Prolymphocytic Leukemia according to GeneCards Suite gene sharing:

(show all 44)
# Super pathways Score Top Affiliating Genes
1
IL-2 Pathway 63
Show member pathways
 13.19 TP53 MYC JAK3 JAK1 FCER2 CR2
2
Endometrial cancer 36
Show member pathways
 12.83 TP53 MYC JAK1 CCND1 ABL1
3
Pathways in cancer 36
12.81 TP53 MYC JAK3 JAK1 CCND1 ABL1
4
PI3K-Akt signaling pathway 36
Show member pathways
 12.75 TP53 TCL1A MYC MTCP1 JAK3 JAK1
5
Measles 36
Show member pathways
 12.68 TP53 MYC JAK3 JAK1 FCER2 CR2
6
ErbB signaling pathway 36 1
Show member pathways
 12.6 TP53 MYC JAK1 CCND1 ABL1
7
NF-kappaB Signaling 4
12.54 ZAP70 JAK3 JAK1 CD38 CD19
8
MicroRNAs in cancer 36
12.51 TP53 MYC CCND1 ATM ABL1
9
Prolactin Signaling Pathway 36 1
Show member pathways
 12.45 ZAP70 MYC JAK1 CCND1
10
JAK-STAT signaling pathway 36
Show member pathways
 12.43 MYC JAK3 JAK1 CCND1 ABL1
11
DNA Damage Response 1
Show member pathways
 12.37 TP53 MYC CCND1 ATM ABL1
12
Cell cycle 36 1
12.35 TP53 MYC CCND1 ATM ABL1
13
Development IGF-1 receptor signaling 22
Show member pathways
 12.34 TP53 MYC JAK3 JAK1 FCER2 CCND1
14
Viral carcinogenesis 36
12.28 TP53 JAK3 JAK1 CCND1
15
Human T-cell leukemia virus 1 infection 36
12.25 TP53 MYC JAK3 JAK1 CCND1 ATM
16
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.24 TP53 MYC JAK1 ATM ABL1
17
p53 Signaling 63
Show member pathways
 12.23 TP53 CCND1 ATM ABL1
18
Colorectal Cancer Metastasis 63
12.17 TP53 MYC JAK1 CCND1
19
Cellular senescence (KEGG) 36
12.14 TP53 MYC CCND1 ATM
20
Integrated Breast Cancer Pathway 1
11.99 TP53 MYC JAK1 CCND1 ATM ABL1
21
DNA Damage Response (only ATM dependent) 1
11.95 TP53 MYC CCND1 ATM ABL1
22
Small cell lung cancer 36
11.83 TP53 MYC CCND1
23
Retinoblastoma (RB) in Cancer 1
11.82 TP53 MYC CCND1 ABL1
24
ATM Pathway 63
Show member pathways
 11.8 TP53 ATM ABL1
25
C-MYB transcription factor network 1
11.75 MYC CCND1 ADA
26
Bladder cancer 36 1
11.72 TP53 MYC CCND1
27
Regulation of Telomerase 1
11.69 MYC CCND1 ATM ABL1
28
IL2 signaling events mediated by PI3K 1
Show member pathways
 11.67 MYC JAK3 JAK1
29
Pathways Affected in Adenoid Cystic Carcinoma 1
11.66 TP53 MYC ATM
30
IL4-mediated signaling events 1
11.64 JAK3 JAK1 FCER2
31
p53 pathway 1
11.61 TP53 ATM ABL1
32
Hepatitis C and Hepatocellular Carcinoma 1
11.57 TP53 MYC JAK1 CCND1
33
Integrated Cancer Pathway 1
11.5 TP53 MYC JAK1 ATM
34
Interleukin-4 and 13 signaling 65
11.49 TP53 MYC JAK3 JAK1 FCER2 CCND1
35
IL-7 Signaling Pathway 1
Show member pathways
 11.47 MYC JAK3 JAK1 CCND1
36
DNA damage_ATM/ATR regulation of G1/S checkpoint 22
11.45 TP53 MYC CCND1 ATM
37
IL-10 Pathway 63
11.34 MYC JAK1 CCND1
38
Primary immunodeficiency 36
11.34 ZAP70 JAK3 CD19 ADA
39
GADD45 Pathway 63
11.29 TP53 CCND1 ATM
40
miRNAs involved in DNA damage response 1
11.25 TP53 MYC CCND1 ATM ABL1
41
Telomere Extension by Telomerase 63
Show member pathways
 11.18 MYC JAK3 JAK1
42
Inhibition of Ribosome Biogenesis by p14(ARF) 63
11.1 TP53 MYC ABL1
43
Hematopoietic cell lineage 36
11.1 FCER2 CR2 CD7 CD5 CD38 CD19
44
TP53 Network 1
Show member pathways
 11.05 TP53 MYC ATM ABL1
Sources

GO Terms for Prolymphocytic Leukemia

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Cellular components related to Prolymphocytic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 9.86 ZAP70 TP53 MYC JAK3 JAK1 FCER2
2 protein-containing complex GO:0032991 9.1 TP53 TCL1A MYC MTCP1 CD19 ABL1

Biological processes related to Prolymphocytic Leukemia according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 10.02 TP53 TCL1A MYC CD38 ADA
2 immune system process GO:0002376 10.01 ZAP70 JAK3 CR2 CD7 CD19 ATM
3 cellular response to DNA damage stimulus GO:0006974 9.98 TP53 MYC CCND1 ATM ABL1
4 regulation of apoptotic process GO:0042981 9.92 TP53 JAK3 ATM ABL1
5 protein phosphorylation GO:0006468 9.85 ZAP70 JAK3 JAK1 CCND1 ATM ABL1
6 positive regulation of response to DNA damage stimulus GO:2001022 9.63 MYC ATM
7 regulation of cell cycle GO:0051726 9.62 TP53 CCND1 ATM ABL1
8 regulation of cellular senescence GO:2000772 9.61 TP53 ABL1
9 replicative senescence GO:0090399 9.61 TP53 ATM
10 interleukin-15-mediated signaling pathway GO:0035723 9.6 JAK3 JAK1
11 positive regulation of mitochondrial membrane potential GO:0010918 9.59 TCL1A MYC
12 interleukin-2-mediated signaling pathway GO:0038110 9.58 JAK3 JAK1
13 T cell activation GO:0042110 9.58 ZAP70 CD7 ADA
14 positive regulation of alpha-beta T cell differentiation GO:0046638 9.57 ZAP70 ADA
15 interleukin-9-mediated signaling pathway GO:0038113 9.56 JAK3 JAK1
16 peptidyl-tyrosine phosphorylation GO:0018108 9.56 ZAP70 JAK3 JAK1 ABL1
17 response to vitamin E GO:0033197 9.55 CCND1 ADA
18 response to drug GO:0042493 9.55 TP53 MYC CD38 CCND1 ADA
19 interleukin-21-mediated signaling pathway GO:0038114 9.52 JAK3 JAK1
20 mitotic G1 DNA damage checkpoint GO:0031571 9.51 TP53 CCND1
21 DNA damage induced protein phosphorylation GO:0006975 9.49 ATM ABL1
22 negative regulation of thymocyte apoptotic process GO:0070244 9.48 JAK3 ADA
23 B cell proliferation involved in immune response GO:0002322 9.46 CD19 ABL1
24 re-entry into mitotic cell cycle GO:0000320 9.43 MYC CCND1
25 cell cycle arrest GO:0007050 9.26 TP53 MYC ATM ABL1
26 cytokine-mediated signaling pathway GO:0019221 9.1 TP53 MYC JAK3 JAK1 FCER2 CCND1

Molecular functions related to Prolymphocytic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kinase activity GO:0016301 9.73 ZAP70 JAK3 JAK1 CCND1 ATM ABL1
2 protein kinase activity GO:0004672 9.63 ZAP70 JAK3 JAK1 CCND1 ATM ABL1
3 protein phosphatase binding GO:0019903 9.5 TP53 JAK3 JAK1
4 protein tyrosine kinase activity GO:0004713 9.26 ZAP70 JAK3 JAK1 ABL1
5 non-membrane spanning protein tyrosine kinase activity GO:0004715 8.92 ZAP70 JAK3 JAK1 ABL1
Sources

Sources for Prolymphocytic Leukemia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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