MCID: PRS013
MIFTS: 36

Prosopagnosia

Categories: Eye diseases, Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Prosopagnosia

MalaCards integrated aliases for Prosopagnosia:

Name: Prosopagnosia 12 53 44 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:4970
MeSH 44 D020238
NCIt 50 C85031
SNOMED-CT 67 18358003
ICD10 32 R48.3
UMLS 71 C0234512

Summaries for Prosopagnosia

NINDS : 53 Prosopagnosia is a neurological disorder characterized by the inability to recognize faces.  Prosopagnosia is also known as face blindness or facial agnosia.  The term prosopagnosia comes from the Greek words for “face” and “lack of knowledge.”   Depending upon the degree of impairment, some people with prosopagnosia may only have difficulty recognizing a familiar face; others will be unable to discriminate between unknown faces, while still others may not even be able to distinguish a face as being different from an object.  Some people with the disorder are unable to recognize their own face.  Prosopagnosia is not related to memory dysfunction, memory loss, impaired vision, or learning disabilities.  Prosopagnosia is thought to be the result of abnormalities, damage, or impairment in the right fusiform gyrus, a fold in the brain that appears to coordinate the neural systems that control facial perception and memory.  Prosopagnosia can result from stroke, traumatic brain injury, or certain neurodegenerative diseases.  In some cases it is a congenital disorder, present at birth in the absence of any brain damage.  Congenital prosopagnosia appears to run in families, which makes it likely to be the result of a genetic mutation or deletion.  Some degree of prosopagnosia is often present in children with autism and Asperger’s syndrome, and may be the cause of their impaired social development.

MalaCards based summary : Prosopagnosia is related to visual agnosia and alexia, and has symptoms including visual agnosia An important gene associated with Prosopagnosia is OXTR (Oxytocin Receptor). The drug Oxytocin has been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and temporal lobe, and related phenotypes are integument and mortality/aging

Disease Ontology : 12 An agnosia that results in the loss of the ability to consciously recognize familiar faces.

Wikipedia : 74 Prosopagnosia (from Greek prósōpon, meaning "face", and agnōsía, meaning "non-knowledge"), also called... more...

Related Diseases for Prosopagnosia

Diseases in the Prosopagnosia family:

Prosopagnosia, Hereditary

Diseases related to Prosopagnosia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 165)
# Related Disease Score Top Affiliating Genes
1 visual agnosia 30.5 PSEN2 MAPT HNMT GRN
2 alexia 30.2 TARDBP PSEN2 MAPT GRN
3 amnestic disorder 30.2 OXT MAPT
4 amusia 30.1 GRN CPZ
5 corticobasal degeneration 30.0 TARDBP MAPT
6 apraxia 30.0 MAPT GRN C9orf72
7 simultanagnosia 29.9 TARDBP PSEN2 MAPT
8 cerebral amyloid angiopathy, cst3-related 29.6 TARDBP PSEN2 MAPT
9 agraphia 29.5 TARDBP MAPT GRN C9orf72
10 lateral sclerosis 29.3 TARDBP CHMP2B C9orf72
11 apperceptive agnosia 29.2 PSEN2 GRN C9orf72 ATP6V0C
12 semantic dementia 29.2 TARDBP MAPT GRN CHMP2B C9orf72
13 huntington disease 29.1 TARDBP PSEN2 MAPT C9orf72
14 associative agnosia 29.0 TARDBP MAPT GRN CHMP2B C9orf72
15 dysgraphia 29.0 TARDBP MAPT GRN CHMP2B C9orf72
16 dementia 28.9 TARDBP PSEN2 MAPT GRN CHMP2B C9orf72
17 alzheimer disease 28.6 TARDBP PSEN2 MAPT HNMT GRN C9orf72
18 nominal aphasia 28.6 TARDBP MAPT GRN CHMP2B C9orf72
19 aphasia 28.6 TARDBP PSEN2 MAPT GRN CHMP2B C9orf72
20 movement disease 28.6 TARDBP MAPT GRN CHMP2B C9orf72
21 frontotemporal dementia 28.6 TARDBP PSEN2 MAPT GRN CHMP2B C9orf72
22 motor neuron disease 28.6 TARDBP MAPT GRN CHMP2B C9orf72
23 amyotrophic lateral sclerosis 1 28.5 TARDBP PSEN2 MAPT GRN CHMP2B C9orf72
24 speech and communication disorders 27.9 TARDBP PSEN2 OXT MAPT GRN CHMP2B
25 prosopagnosia, hereditary 11.7
26 agnosia 10.7
27 yemenite deaf-blind hypopigmentation syndrome 10.4
28 autotopagnosia 10.3 KLK4 HNMT
29 frontotemporal lobar degeneration with tdp43 inclusions, grn-related 10.3 MAPT GRN
30 akinetopsia 10.3 KLK4 HNMT
31 akinetic mutism 10.2 TARDBP MAPT
32 postencephalitic parkinson disease 10.2 TARDBP MAPT
33 inhibited female orgasm 10.2 OXTR OXT
34 tactile agnosia 10.2 PSEN2 OXTR
35 kluver-bucy syndrome 10.2 OXT GRN
36 pedophilia 10.2 OXT GRN
37 arteriolosclerosis 10.2 TARDBP MAPT
38 lipoid proteinosis of urbach and wiethe 10.2 OXTR OXT
39 separation anxiety disorder 10.2 OXTR OXT
40 paraphilia disorder 10.2 OXT GRN
41 atypical autism 10.2 OXTR OXT
42 phobic disorder 10.2 OXTR OXT
43 alexithymia 10.2 OXTR OXT
44 autism spectrum disorder 10.2
45 dyslexia 10.2
46 alzheimer disease 2 10.2 PSEN2 MAPT
47 communicating hydrocephalus 10.1 PSEN2 MAPT
48 achromatopsia 10.1
49 oppositional defiant disorder 10.1 OXTR OXT
50 locked-in syndrome 10.1 TARDBP CPZ

Graphical network of the top 20 diseases related to Prosopagnosia:



Diseases related to Prosopagnosia

Symptoms & Phenotypes for Prosopagnosia

UMLS symptoms related to Prosopagnosia:


visual agnosia

MGI Mouse Phenotypes related to Prosopagnosia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.7 C9orf72 GRN MAPT OXT OXTR PSEN2
2 mortality/aging MP:0010768 9.65 ATP6V0C C9orf72 CHMP2B GRN KLK4 MAPT
3 nervous system MP:0003631 9.28 C9orf72 CHMP2B GRN HNMT MAPT OXT

Drugs & Therapeutics for Prosopagnosia

Drugs for Prosopagnosia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oxytocin Approved, Vet_approved Early Phase 1 50-56-6 439302 53477758

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Behavioral and Neural Effects of Oxytocin on Face Perception in Congenital Prosopagnosia Suspended NCT02091817 Early Phase 1 Oxytocin;Placebo

Search NIH Clinical Center for Prosopagnosia

Cochrane evidence based reviews: prosopagnosia

Genetic Tests for Prosopagnosia

Anatomical Context for Prosopagnosia

MalaCards organs/tissues related to Prosopagnosia:

40
Brain, Cortex, Temporal Lobe, Eye, Occipital Lobe, Bone Marrow, Skin

Publications for Prosopagnosia

Articles related to Prosopagnosia:

(show top 50) (show all 848)
# Title Authors PMID Year
1
Face recognition in developmental dyslexia: evidence for dissociation between faces and words. 61
33241970 2021
2
Selective defects of face familiarity associated to a left temporo-occipital lesion. 61
32648048 2021
3
Patterns of perceptual performance in developmental prosopagnosia: An in-depth case series. 61
33459172 2021
4
Different and common brain signals of altered neurocognitive mechanisms for unfamiliar face processing in acquired and developmental prosopagnosia. 61
33271437 2021
5
Cerebral trauma-induced dyschromatopsia in the left hemifield: case presentation. 61
33504343 2021
6
Parosmia in Right-lateralized Semantic Variant Primary Progressive Aphasia: A Case Report. 61
33443872 2021
7
Associations between self-reported and objective face recognition abilities are only evident in above- and below-average recognisers. 61
33510971 2021
8
Delayed diagnosis of prosopagnosia following a hemorrhagic stroke in an elderly man: A case report. 61
33392335 2020
9
An Unusual Todd's Phenomenon: Post-Ictal Prosopagnosia. 61
33272342 2020
10
Neural responses in a fast periodic visual stimulation paradigm reveal domain-general visual discrimination deficits in developmental prosopagnosia. 61
33099077 2020
11
Prosopagnosia seizure semiology in a 10-year-old boy: a functional neuroimaging study. 61
33370980 2020
12
Coping strategies for developmental prosopagnosia. 61
31161896 2020
13
Normal recognition of famous voices in developmental prosopagnosia. 61
33184411 2020
14
Prosopagnosia. 61
32951850 2020
15
Understanding human individuation of unfamiliar faces with oddball fast periodic visual stimulation and electroencephalography. 61
32542962 2020
16
Face individual identity recognition: a potential endophenotype in autism. 61
33081830 2020
17
Apperceptive Prosopagnosia Secondary to an Ischemic Infarct of the Lingual Gyrus: A Case Report and an Update on the Neuroanatomy, Neurophysiology, and Phenomenology of Prosopagnosia. 61
33274147 2020
18
Attentional modulation differentially affects ventral and dorsal face areas in both normal participants and developmental prosopagnosics. 61
32490718 2020
19
Characterizing developmental prosopagnosia beyond face perception: Impaired recollection but intact familiarity recognition. 61
32640375 2020
20
Holistic processing of facial identity in developmental prosopagnosia. 61
32721648 2020
21
Evidence for normal novel object recognition abilities in developmental prosopagnosia. 61
33047056 2020
22
Diagnosing developmental prosopagnosia: repeat assessment using the Cambridge Face Memory Test. 61
33047048 2020
23
A clinical-radiological framework of the right temporal variant of frontotemporal dementia. 61
32830218 2020
24
Bayesian regression-based developmental norms for the Benton Facial Recognition Test in males and females. 61
31907754 2020
25
Rapid forgetting of faces in congenital prosopagnosia. 61
32450329 2020
26
[Evaluation of Semantic Dementia Patient]. 61
32507758 2020
27
Editorial commentary: The anatomical basis of prosopagnosia-facial blindness, do you see what I see? 61
32295859 2020
28
Search for Face Identity or Expression: Set Size Effects in Developmental Prosopagnosia. 61
31905091 2020
29
Multi-Item Discriminability Pattern to Faces in Developmental Prosopagnosia Reveals Distinct Mechanisms of Face Processing. 61
31813985 2020
30
Anomalous visual experience is linked to perceptual uncertainty and visual imagery vividness. 61
32476064 2020
31
Posterior primary progressive prosopagnosia: Structural and molecular imaging. 61
31964687 2020
32
Developmental Prosopagnosia and Elastic Versus Static Face Recognition in an Incidental Learning Task. 61
32982859 2020
33
Difficulty differentiating a case of posterior cortical atrophy from a psychogenic disturbance of vision. 61
30997705 2020
34
A case of aneurysmal subarchnoid haemorrhage and superficial siderosis complicated by prospagnosia, simultagnosia and alexia without agraphia. 61
31790281 2019
35
Looking beyond the face area: lesion network mapping of prosopagnosia. 61
31740940 2019
36
The discrimination of facial sex in developmental prosopagnosia. 61
31836836 2019
37
The domain-specificity of face matching impairments in 40 cases of developmental prosopagnosia. 61
31351346 2019
38
Training face perception in developmental prosopagnosia through perceptual learning. 61
31541661 2019
39
Atypical holistic processing of facial identity and expression in a case of acquired prosopagnosia. 61
31983272 2019
40
Does developmental prosopagnosia impair identification of other-ethnicity faces? 61
31071553 2019
41
Pearls & Oy-sters: Isolated prosopagnosia as the presenting complaint in glioblastoma: The face of deception. 61
31570639 2019
42
The cortical face network of the prosopagnosic patient PS with fast periodic stimulation in fMRI. 61
30545601 2019
43
First the nose, last the eyes in congenital prosopagnosia: Look like your father looks. 61
31094554 2019
44
Developmental prosopagnosia with concurrent topographical difficulties: A case report and virtual reality training programme. 61
29206082 2019
45
[Visual perceptual disorders in Alzheimer's disease]. 61
31449049 2019
46
Eye movements and retinotopic tuning in developmental prosopagnosia. 61
31426085 2019
47
The Scanpaths of Subjects with Developmental Prosopagnosia during a Face Memory Task. 61
31382482 2019
48
Self-reported face recognition is highly valid, but alone is not highly discriminative of prosopagnosia-level performance on objective assessments. 61
30761463 2019
49
Objective Patterns of Face Recognition Deficits in 165 Adults with Self-Reported Developmental Prosopagnosia. 61
31174381 2019
50
Self-ratings of face recognition ability are influenced by gender but not prosopagnosia severity. 61
30730191 2019

Variations for Prosopagnosia

Expression for Prosopagnosia

Search GEO for disease gene expression data for Prosopagnosia.

Pathways for Prosopagnosia

GO Terms for Prosopagnosia

Cellular components related to Prosopagnosia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth cone GO:0030426 9.13 PSEN2 MAPT C9orf72
2 main axon GO:0044304 8.62 MAPT C9orf72

Biological processes related to Prosopagnosia according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 memory GO:0007613 9.61 OXTR OXT MAPT
2 response to steroid hormone GO:0048545 9.55 OXTR OXT
3 response to amphetamine GO:0001975 9.54 OXTR OXT
4 eating behavior GO:0042755 9.52 OXTR OXT
5 positive regulation of blood pressure GO:0045777 9.51 OXTR OXT
6 stress granule assembly GO:0034063 9.49 MAPT C9orf72
7 maternal behavior GO:0042711 9.48 OXTR OXT
8 sleep GO:0030431 9.46 OXTR OXT
9 positive regulation of uterine smooth muscle contraction GO:0070474 9.4 OXTR OXT
10 negative regulation of gastric acid secretion GO:0060455 9.37 OXTR OXT
11 positive regulation of penile erection GO:0060406 9.32 OXTR OXT
12 sperm ejaculation GO:0042713 9.26 OXTR OXT
13 positive regulation of norepinephrine secretion GO:0010701 9.16 OXTR OXT
14 response to cocaine GO:0042220 9.13 OXTR OXT HNMT
15 regulation of digestive system process GO:0044058 8.62 OXTR OXT

Sources for Prosopagnosia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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