MCID: PRS013
MIFTS: 34

Prosopagnosia

Categories: Mental diseases, Rare diseases

Aliases & Classifications for Prosopagnosia

MalaCards integrated aliases for Prosopagnosia:

Name: Prosopagnosia 12 54 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4970
ICD10 33 R48.3
MeSH 44 D020238
NCIt 50 C85031
SNOMED-CT 68 18358003
UMLS 73 C0234512

Summaries for Prosopagnosia

NINDS : 54 Prosopagnosia is a neurological disorder characterized by the inability to recognize faces.  Prosopagnosia is also known as face blindness or facial agnosia.  The term prosopagnosia comes from the Greek words for “face” and “lack of knowledge.”   Depending upon the degree of impairment, some people with prosopagnosia may only have difficulty recognizing a familiar face; others will be unable to discriminate between unknown faces, while still others may not even be able to distinguish a face as being different from an object.  Some people with the disorder are unable to recognize their own face.  Prosopagnosia is not related to memory dysfunction, memory loss, impaired vision, or learning disabilities.  Prosopagnosia is thought to be the result of abnormalities, damage, or impairment in the right fusiform gyrus, a fold in the brain that appears to coordinate the neural systems that control facial perception and memory.  Prosopagnosia can result from stroke, traumatic brain injury, or certain neurodegenerative diseases.  In some cases it is a congenital disorder, present at birth in the absence of any brain damage.  Congenital prosopagnosia appears to run in families, which makes it likely to be the result of a genetic mutation or deletion.  Some degree of prosopagnosia is often present in children with autism and Asperger’s syndrome, and may be the cause of their impaired social development. 

MalaCards based summary : Prosopagnosia is related to visual agnosia and semantic dementia, and has symptoms including visual agnosia An important gene associated with Prosopagnosia is OXTR (Oxytocin Receptor). The drugs Oxytocin and Oxytocics have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and eye.

Disease Ontology : 12 An agnosia that results in the loss of the ability to consciously recognize familiar faces.

Wikipedia : 76 Prosopagnosia, also called face blindness, is a cognitive disorder of face perception in which the... more...

Related Diseases for Prosopagnosia

Diseases in the Prosopagnosia family:

Prosopagnosia, Hereditary

Diseases related to Prosopagnosia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Related Disease Score Top Affiliating Genes
1 visual agnosia 30.2 GRN PSEN1
2 semantic dementia 30.1 GRN PSEN1
3 phonagnosia 29.9 GRN PSEN1
4 agraphia 29.7 GRN PSEN1
5 prosopagnosia, hereditary 12.5
6 agnosia 10.3
7 associative agnosia 10.2 GRN PSEN1
8 progressive non-fluent aphasia 10.2 GRN PSEN1
9 behavioral variant of frontotemporal dementia 10.2 GRN PSEN1
10 writing disorder 10.2 GRN PSEN1
11 gait apraxia 10.2 GRN PSEN1
12 echolalia 10.2 GRN PSEN1
13 transient global amnesia 10.1 EP300 PSEN1
14 alexia 10.1
15 nominal aphasia 10.1 GRN PSEN1
16 basal ganglia disease 10.1 GRN PSEN1
17 frontotemporal dementia and/or amyotrophic lateral sclerosis 1 10.1 GRN PSEN1
18 aphasia 10.1 GRN PSEN1
19 pick disease of brain 10.0 GRN PSEN1
20 dementia 10.0
21 cerebritis 10.0
22 capgras syndrome 10.0
23 supranuclear palsy, progressive, 1 10.0 GRN PSEN1
24 apraxia 10.0 GRN PSEN1
25 asperger syndrome 9.9
26 encephalitis 9.9
27 specific developmental disorder 9.9 GRN PSEN1
28 dementia, lewy body 9.9 GRN PSEN1
29 aging 9.8
30 head injury 9.8
31 speech and communication disorders 9.8 GRN PSEN1
32 alzheimer disease 9.7
33 cerebral amyloid angiopathy, cst3-related 9.7
34 schizophrenia 9.7
35 autism 9.7
36 hydrocephalus, normal-pressure 9.7
37 phenylketonuria 9.7
38 cognitive function 1, social 9.7
39 stroke, ischemic 9.7
40 hemorrhage, intracerebral 9.7
41 achromatopsia 9.7
42 hydrocephalus 9.7
43 anosognosia 9.7
44 simultanagnosia 9.7
45 migraine with aura 9.7
46 arteriovenous malformation 9.7
47 cortical blindness 9.7
48 conversion disorder 9.7
49 status epilepticus 9.7
50 transient cerebral ischemia 9.7

Graphical network of the top 20 diseases related to Prosopagnosia:



Diseases related to Prosopagnosia

Symptoms & Phenotypes for Prosopagnosia

UMLS symptoms related to Prosopagnosia:


visual agnosia

Drugs & Therapeutics for Prosopagnosia

Drugs for Prosopagnosia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oxytocin Approved, Vet_approved Early Phase 1 50-56-6 439302 53477758
2 Oxytocics Early Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Effect of Oxytocin on Face Perception Suspended NCT02091817 Early Phase 1 Oxytocin;Placebo

Search NIH Clinical Center for Prosopagnosia

Cochrane evidence based reviews: prosopagnosia

Genetic Tests for Prosopagnosia

Anatomical Context for Prosopagnosia

MalaCards organs/tissues related to Prosopagnosia:

41
Brain, Testes, Eye, Cortex, Temporal Lobe, Skin

Publications for Prosopagnosia

Articles related to Prosopagnosia:

(show top 50) (show all 414)
# Title Authors Year
1
Mapping self-face recognition strategies in congenital prosopagnosia. ( 29528679 )
2018
2
Congenital prosopagnosia: Deficit diagnosis and beyond. ( 29658422 )
2018
3
Ensemble coding of face identity is present but weaker in congenital prosopagnosia. ( 29454895 )
2018
4
Adults have moderate-to-good insight into their face recognition ability: Further validation of the 20-item Prosopagnosia Index in a Portuguese sample. ( 29504464 )
2018
5
Inversion effects for faces and objects in developmental prosopagnosia: A case series analysis. ( 29596857 )
2018
6
The face specificity of lifelong prosopagnosia. ( 29658417 )
2018
7
Prosopagnosia as a Type of Conversion Disorder. ( 29666739 )
2018
8
Reading in developmental prosopagnosia: Evidence for a dissociation between word and face recognition. ( 29528680 )
2018
9
Using Prosopagnosia to Test and Modify Visual Recognition Theory. ( 29228849 )
2018
10
Visual crowding in pure alexia and acquired prosopagnosia. ( 29902952 )
2018
11
Face specificity of developmental prosopagnosia, moving beyond the debate on face specificity. ( 29658420 )
2018
12
Damasio's error - Prosopagnosia with intact within-category object recognition. ( 29845731 )
2018
13
A possible neuronal account for the behavioural heterogeneity in congenital prosopagnosia. ( 29658411 )
2018
14
Diagnosing Prosopagnosia: The Utility of Visual Noise in the Cambridge Face Recognition Test. ( 29320938 )
2018
15
Teaching NeuroImages: Prosopagnosia heralding anti-NMDA receptor encephalitis. ( 29807927 )
2018
16
Decisional space determines saccadic reaction times in healthy observers and acquired prosopagnosia. ( 29749293 )
2018
17
Decoupling category level and perceptual similarity in congenital prosopagnosia. ( 29658419 )
2018
18
Should developmental prosopagnosia, developmental body agnosia, and developmental object agnosia be considered independent neurodevelopmental conditions? ( 29658410 )
2018
19
Identifying Hallmark Symptoms of Developmental Prosopagnosia for Non-Experts. ( 29374245 )
2018
20
Impaired perception of facial emotion in developmental prosopagnosia: A reply to Van den Stock's commentary. ( 29288013 )
2017
21
Intact word processing in developmental prosopagnosia. ( 28490791 )
2017
22
Tumoral Presentation of Homonymous Hemianopia and Prosopagnosia in Cerebral Amyloid Angiopathy-Related Inflammation. ( 28187081 )
2017
23
A novel PSEN1 (S230N) mutation causing early-onset Alzheimer's Disease associated with prosopagnosia, hoarding, and Parkinsonism. ( 28764909 )
2017
24
Diagnosing prosopagnosia in East Asian individuals: Norms for the Cambridge Face Memory Test-Chinese. ( 28906173 )
2017
25
Developmental visual perception deficits with no indications of prosopagnosia in a child with abnormal eye movements. ( 28400326 )
2017
26
Normal composite face effects in developmental prosopagnosia. ( 28850918 )
2017
27
What do eye movements tell us about the visual perception of individuals with congenital prosopagnosia? ( 28368140 )
2017
28
Impaired processing of facial happiness, with or without awareness, in developmental prosopagnosia. ( 28648569 )
2017
29
Robust associations between the 20-item prosopagnosia index and the Cambridge Face Memory Test in the general population. ( 28405380 )
2017
30
Altered topology of neural circuits in congenital prosopagnosia. ( 28825896 )
2017
31
Prosopagnosia Induced by a Left Anterior Temporal lobectomy Following a Right Temporo-occipital Resection in a Multicentric Diffuse Low-Grade Glioma. ( 27756661 )
2017
32
Gaze-cueing requires intact face processing - Insights from acquired prosopagnosia. ( 28193545 )
2017
33
Delayed processing of global shape information in developmental prosopagnosia. ( 29261708 )
2017
34
Face working memory deficits in developmental prosopagnosia: Tests of encoding limits and updating processes. ( 28888893 )
2017
35
Mapping the impairment in decoding static facial expressions of emotion in prosopagnosia. ( 28459990 )
2017
36
Congenital prosopagnosia without object agnosia? A literature review. ( 29165034 )
2017
37
People with and without prosopagnosia have insight into their face recognition ability. ( 28513322 )
2017
38
Developmental prosopagnosia with concurrent topographical difficulties: A case report and virtual reality training programme. ( 29206082 )
2017
39
Perceptual Learning of Faces: A Rehabilitative Study of Acquired Prosopagnosia. ( 28139958 )
2017
40
Face identity matching is selectively impaired in developmental prosopagnosia. ( 28189665 )
2017
41
The neural network for face recognition: Insights from an fMRI study on developmental prosopagnosia. ( 29242103 )
2017
42
Impaired body perception in developmental prosopagnosia. ( 28618296 )
2017
43
Perceptual and memorial contributions to developmental prosopagnosia. ( 27079768 )
2016
44
Phasic alertness enhances processing of face and non-face stimuli in congenital prosopagnosia. ( 27364232 )
2016
45
Topographic processing in developmental prosopagnosia: Preserved perception but impaired memory of scenes. ( 28034340 )
2016
46
The cognitive and neural basis of developmental prosopagnosia. ( 26967836 )
2016
47
Transient Prosopagnosia With Right Temporal Astrocytoma. ( 26844963 )
2016
48
Getting lost: Topographic skills in acquired and developmental prosopagnosia. ( 26874939 )
2016
49
Impaired perception of facial emotion in developmental prosopagnosia. ( 27208814 )
2016
50
Developmental prosopagnosia. ( 27115682 )
2016

Variations for Prosopagnosia

Expression for Prosopagnosia

Search GEO for disease gene expression data for Prosopagnosia.

Pathways for Prosopagnosia

GO Terms for Prosopagnosia

Biological processes related to Prosopagnosia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Notch signaling pathway GO:0007219 9.37 EP300 PSEN1
2 positive regulation of DNA binding transcription factor activity GO:0051091 9.32 EP300 PPRC1
3 memory GO:0007613 9.26 OXTR PSEN1
4 positive regulation of protein binding GO:0032092 9.16 EP300 PSEN1
5 somitogenesis GO:0001756 8.96 EP300 PSEN1
6 heart development GO:0007507 8.8 EP300 OXTR PSEN1

Molecular functions related to Prosopagnosia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 beta-catenin binding GO:0008013 8.96 EP300 PSEN1
2 transcription coregulator activity GO:0003712 8.62 EP300 PPRC1

Sources for Prosopagnosia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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