MCID: PRS013
MIFTS: 33

Prosopagnosia

Categories: Eye diseases, Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Prosopagnosia

MalaCards integrated aliases for Prosopagnosia:

Name: Prosopagnosia 12 53 43 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:4970
MeSH 43 D020238
NCIt 49 C85031
SNOMED-CT 67 18358003
ICD10 32 R48.3
UMLS 71 C0234512

Summaries for Prosopagnosia

NINDS : 53 Prosopagnosia is a neurological disorder characterized by the inability to recognize faces.  Prosopagnosia is also known as face blindness or facial agnosia.  The term prosopagnosia comes from the Greek words for “face” and “lack of knowledge.”   Depending upon the degree of impairment, some people with prosopagnosia may only have difficulty recognizing a familiar face; others will be unable to discriminate between unknown faces, while still others may not even be able to distinguish a face as being different from an object.  Some people with the disorder are unable to recognize their own face.  Prosopagnosia is not related to memory dysfunction, memory loss, impaired vision, or learning disabilities.  Prosopagnosia is thought to be the result of abnormalities, damage, or impairment in the right fusiform gyrus, a fold in the brain that appears to coordinate the neural systems that control facial perception and memory.  Prosopagnosia can result from stroke, traumatic brain injury, or certain neurodegenerative diseases.  In some cases it is a congenital disorder, present at birth in the absence of any brain damage.  Congenital prosopagnosia appears to run in families, which makes it likely to be the result of a genetic mutation or deletion.  Some degree of prosopagnosia is often present in children with autism and Asperger’s syndrome, and may be the cause of their impaired social development.

MalaCards based summary : Prosopagnosia is related to semantic dementia and amusia, and has symptoms including visual agnosia An important gene associated with Prosopagnosia is OXTR (Oxytocin Receptor). The drug Oxytocin has been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex, and related phenotype is no phenotypic analysis.

Disease Ontology : 12 An agnosia that results in the loss of the ability to consciously recognize familiar faces.

Wikipedia : 74 Prosopagnosia (from Greek prósōpon, meaning "face", and agnōsía, meaning "non-knowledge"), also called... more...

Related Diseases for Prosopagnosia

Diseases in the Prosopagnosia family:

Prosopagnosia, Hereditary

Diseases related to Prosopagnosia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 125)
# Related Disease Score Top Affiliating Genes
1 semantic dementia 30.5 TARDBP MAPT GRN
2 amusia 30.5 KCNK3 GRN
3 visual agnosia 30.4 MAPT HNMT GRN EEF1AKNMT
4 associative agnosia 30.3 TARDBP MAPT GRN
5 dysgraphia 30.3 TARDBP MAPT GRN
6 suppression amblyopia 30.3 TNFRSF10C HNMT
7 corticobasal degeneration 30.0 TARDBP MAPT
8 movement disease 29.9 TARDBP MAPT GRN
9 agraphia 29.9 TARDBP PRSS3 MAPT GRN
10 integrative agnosia 29.9 KLK4 KCNK5 KCNK3
11 alexia 29.7 PRSS3 MAPT KCNK5 KCNK3 GRN ASPRV1
12 aphasia 29.7 TARDBP PRSS3 MAPT GRN ASPRV1
13 nominal aphasia 29.7 TARDBP PRSS3 MAPT GRN
14 speech and communication disorders 29.1 TNFRSF10C TARDBP PRSS3 MAPT GRN ASPRV1
15 prosopagnosia, hereditary 12.9
16 agnosia 10.8
17 yemenite deaf-blind hypopigmentation syndrome 10.5
18 frontotemporal lobar degeneration with tdp43 inclusions, grn-related 10.4 MAPT GRN
19 progressive non-fluent aphasia 10.4 MAPT GRN
20 animal phobia 10.3 TNFRSF10C ASPRV1
21 autism spectrum disorder 10.3
22 dementia 10.3
23 dyslexia 10.3
24 mutism 10.3 MAPT GRN
25 achromatopsia 10.3
26 amnestic disorder 10.2
27 vascular disease 10.2
28 capgras syndrome 10.2
29 encephalitis 10.2
30 phobic disorder 10.2 TNFRSF10C OXTR ASPRV1
31 akinetic mutism 10.2 TARDBP MAPT
32 postencephalitic parkinson disease 10.2 TARDBP MAPT
33 frontotemporal dementia 10.1
34 asperger syndrome 10.1
35 apraxia 10.1
36 arteriovenous malformation 10.1
37 cortical blindness 10.1
38 pica disease 10.1 TARDBP MAPT
39 echolalia 10.1 MAPT GRN
40 pontiac fever 10.1 RCE1 ASPRV1
41 breast leiomyosarcoma 10.1 KCNK5 KCNK3
42 frontotemporal dementia, chromosome 3-linked 10.1 TARDBP MAPT GRN
43 lipoid proteinosis of urbach and wiethe 10.1 OXTR AMELX
44 perry syndrome 10.1 TARDBP MAPT GRN
45 arteriolosclerosis 10.1 TARDBP MAPT
46 amyotrophic lateral sclerosis 1 10.1
47 migraine with or without aura 1 10.1
48 teratoma, ovarian 10.1
49 stroke, ischemic 10.1
50 anosognosia 10.1

Graphical network of the top 20 diseases related to Prosopagnosia:



Diseases related to Prosopagnosia

Symptoms & Phenotypes for Prosopagnosia

UMLS symptoms related to Prosopagnosia:


visual agnosia

MGI Mouse Phenotypes related to Prosopagnosia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 no phenotypic analysis MP:0003012 9.1 GPSM2 GRN KCNK3 MAPT OXTR TARDBP

Drugs & Therapeutics for Prosopagnosia

Drugs for Prosopagnosia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oxytocin Approved, Vet_approved Early Phase 1 50-56-6 53477758 439302

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Behavioral and Neural Effects of Oxytocin on Face Perception in Congenital Prosopagnosia Suspended NCT02091817 Early Phase 1 Oxytocin;Placebo

Search NIH Clinical Center for Prosopagnosia

Cochrane evidence based reviews: prosopagnosia

Genetic Tests for Prosopagnosia

Anatomical Context for Prosopagnosia

MalaCards organs/tissues related to Prosopagnosia:

40
Brain, Testes, Cortex, Eye, Temporal Lobe, Occipital Lobe, Bone Marrow

Publications for Prosopagnosia

Articles related to Prosopagnosia:

(show top 50) (show all 829)
# Title Authors PMID Year
1
Understanding human individuation of unfamiliar faces with oddball fast periodic visual stimulation and electroencephalography. 61
32542962 2020
2
[Evaluation of Semantic Dementia Patient]. 61
32507758 2020
3
Attentional modulation differentially affects ventral and dorsal face areas in both normal participants and developmental prosopagnosics. 61
32490718 2020
4
Anomalous visual experience is linked to perceptual uncertainty and visual imagery vividness. 61
32476064 2020
5
Editorial commentary: The anatomical basis of prosopagnosia-facial blindness, do you see what I see? 61
32295859 2020
6
Multi-Item Discriminability Pattern to Faces in Developmental Prosopagnosia Reveals Distinct Mechanisms of Face Processing. 61
31813985 2020
7
Search for Face Identity or Expression: Set Size Effects in Developmental Prosopagnosia. 61
31905091 2020
8
Rapid forgetting of faces in congenital prosopagnosia. 61
32450329 2020
9
Posterior primary progressive prosopagnosia: Structural and molecular imaging. 61
31964687 2020
10
Difficulty differentiating a case of posterior cortical atrophy from a psychogenic disturbance of vision. 61
30997705 2020
11
Bayesian regression-based developmental norms for the Benton Facial Recognition Test in males and females. 61
31907754 2020
12
A case of aneurysmal subarchnoid haemorrhage and superficial siderosis complicated by prospagnosia, simultagnosia and alexia without agraphia. 61
31790281 2019
13
The discrimination of facial sex in developmental prosopagnosia. 61
31836836 2019
14
Looking beyond the face area: lesion network mapping of prosopagnosia. 61
31740940 2019
15
Training face perception in developmental prosopagnosia through perceptual learning. 61
31541661 2019
16
The domain-specificity of face matching impairments in 40 cases of developmental prosopagnosia. 61
31351346 2019
17
Atypical holistic processing of facial identity and expression in a case of acquired prosopagnosia. 61
31983272 2019
18
Does developmental prosopagnosia impair identification of other-ethnicity faces? 61
31071553 2019
19
Pearls & Oy-sters: Isolated prosopagnosia as the presenting complaint in glioblastoma: The face of deception. 61
31570639 2019
20
The cortical face network of the prosopagnosic patient PS with fast periodic stimulation in fMRI. 61
30545601 2019
21
First the nose, last the eyes in congenital prosopagnosia: Look like your father looks. 61
31094554 2019
22
Developmental prosopagnosia with concurrent topographical difficulties: A case report and virtual reality training programme. 61
29206082 2019
23
Visual perceptual disorders in Alzheimer's disease. 61
31449049 2019
24
Eye movements and retinotopic tuning in developmental prosopagnosia. 61
31426085 2019
25
The Scanpaths of Subjects with Developmental Prosopagnosia during a Face Memory Task. 61
31382482 2019
26
Self-reported face recognition is highly valid, but alone is not highly discriminative of prosopagnosia-level performance on objective assessments. 61
30761463 2019
27
Multifaceted Integration: Memory for Faces Is Subserved by Widespread Connections between Visual, Memory, Auditory, and Social Networks. 61
31036762 2019
28
Objective Patterns of Face Recognition Deficits in 165 Adults with Self-Reported Developmental Prosopagnosia. 61
31174381 2019
29
Self-ratings of face recognition ability are influenced by gender but not prosopagnosia severity. 61
30730191 2019
30
Coping strategies for developmental prosopagnosia. 61
31161896 2019
31
Caricaturing as a general method to improve poor face recognition: Evidence from low-resolution images, other-race faces, and older adults. 61
30321022 2019
32
Atypical non-progressive semantic impairment following allogeneic bone marrow transplantation in a patient with Waldenström's macroglobulinemia: A case report. 61
30468103 2019
33
Face Recognition. 61
31144153 2019
34
Facing the facts: Naive participants have only moderate insight into their face recognition and face perception abilities. 61
29706121 2019
35
Storage, Degradation, and New Connectivity of Face-Related Semantic Memory in Alzheimer's Disease. 61
31007428 2019
36
Evidence of taxonomy for Developmental Topographical Disorientation: Developmental Landmark Agnosia Case 1. 61
29192795 2019
37
A Computational Model of Visual Recognition Memory via Grid Cells. 61
30853437 2019
38
Self-face and self-body advantages in congenital prosopagnosia: evidence for a common mechanism. 61
30542755 2019
39
Object recognition in acquired and developmental prosopagnosia. 61
30947609 2019
40
Is developmental prosopagnosia best characterised as an apperceptive or mnemonic condition? 61
30502377 2019
41
Evaluating object recognition ability in developmental prosopagnosia using the Cambridge Car Memory Test. 61
30973292 2019
42
Perception of musical pitch in developmental prosopagnosia. 61
30625291 2019
43
Transient Dyschromatopsia, Static Form Agnosia, and Prosopagnosia Observed in a Patient with Anti-NMDA Receptor Encephalitis. 61
31061739 2019
44
Suicide as a result of stereotypic behaviour in a case with semantic dementia. 61
30058742 2019
45
Developmental Cognitive Deficits: A Historical Overview of Early Cases. 61
31220836 2019
46
Cognitive and Behavioral Profiles of Left and Right Semantic Dementia: Differential Diagnosis with Behavioral Variant Frontotemporal Dementia and Alzheimer's Disease. 61
31683488 2019
47
Subjective assessment for super recognition: an evaluation of self-report methods in civilian and police participants. 61
30723622 2019
48
Progress in perceptual research: the case of prosopagnosia. 61
31231507 2019
49
The hidden identity of faces: a case of lifelong prosopagnosia. 61
30670082 2019
50
System for Face Recognition under Different Facial Expressions Using a New Associative Hybrid Model Amαβ-KNN for People with Visual Impairment or Prosopagnosia. 61
30704082 2019

Variations for Prosopagnosia

Expression for Prosopagnosia

Search GEO for disease gene expression data for Prosopagnosia.

Pathways for Prosopagnosia

GO Terms for Prosopagnosia

Cellular components related to Prosopagnosia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell GO:0005623 9.1 OXTR MAPT KCNK3 GRN GPSM2 ATP6V0C

Biological processes related to Prosopagnosia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 biomineral tissue development GO:0031214 8.96 KLK4 AMELX
2 stabilization of membrane potential GO:0030322 8.62 KCNK5 KCNK3

Molecular functions related to Prosopagnosia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 potassium ion leak channel activity GO:0022841 8.62 KCNK5 KCNK3

Sources for Prosopagnosia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....