MCID: PRS013
MIFTS: 34

Prosopagnosia

Categories: Eye diseases, Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Prosopagnosia

MalaCards integrated aliases for Prosopagnosia:

Name: Prosopagnosia 12 54 44 15 72

Classifications:



External Ids:

Disease Ontology 12 DOID:4970
MeSH 44 D020238
NCIt 50 C85031
SNOMED-CT 68 18358003
ICD10 33 R48.3
UMLS 72 C0234512

Summaries for Prosopagnosia

NINDS : 54 Prosopagnosia is a neurological disorder characterized by the inability to recognize faces.  Prosopagnosia is also known as face blindness or facial agnosia.  The term prosopagnosia comes from the Greek words for “face” and “lack of knowledge.”   Depending upon the degree of impairment, some people with prosopagnosia may only have difficulty recognizing a familiar face; others will be unable to discriminate between unknown faces, while still others may not even be able to distinguish a face as being different from an object.  Some people with the disorder are unable to recognize their own face.  Prosopagnosia is not related to memory dysfunction, memory loss, impaired vision, or learning disabilities.  Prosopagnosia is thought to be the result of abnormalities, damage, or impairment in the right fusiform gyrus, a fold in the brain that appears to coordinate the neural systems that control facial perception and memory.  Prosopagnosia can result from stroke, traumatic brain injury, or certain neurodegenerative diseases.  In some cases it is a congenital disorder, present at birth in the absence of any brain damage.  Congenital prosopagnosia appears to run in families, which makes it likely to be the result of a genetic mutation or deletion.  Some degree of prosopagnosia is often present in children with autism and Asperger’s syndrome, and may be the cause of their impaired social development.

MalaCards based summary : Prosopagnosia is related to prosopagnosia, hereditary and agnosia, and has symptoms including visual agnosia An important gene associated with Prosopagnosia is OXTR (Oxytocin Receptor), and among its related pathways/superpathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Hepatic ABC Transporters. The drugs Oxytocin and Oxytocics have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex.

Disease Ontology : 12 An agnosia that results in the loss of the ability to consciously recognize familiar faces.

Wikipedia : 75 Prosopagnosia, also called face blindness, is a cognitive disorder of face perception in which the... more...

Related Diseases for Prosopagnosia

Diseases in the Prosopagnosia family:

Prosopagnosia, Hereditary

Diseases related to Prosopagnosia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 100)
# Related Disease Score Top Affiliating Genes
1 prosopagnosia, hereditary 12.9
2 agnosia 10.8
3 visual agnosia 10.6
4 yemenite deaf-blind hypopigmentation syndrome 10.5
5 alexia 10.4
6 dementia 10.3
7 autism spectrum disorder 10.3
8 dyslexia 10.3
9 achromatopsia 10.2
10 semantic dementia 10.2
11 autism 10.2
12 amnestic disorder 10.2
13 vascular disease 10.2
14 capgras syndrome 10.2
15 encephalitis 10.2
16 frontotemporal dementia 10.1
17 asperger syndrome 10.1
18 aphasia 10.1
19 apraxia 10.1
20 associative agnosia 10.1
21 arteriovenous malformation 10.1
22 cortical blindness 10.1
23 dysgraphia 10.1
24 amyotrophic lateral sclerosis 1 10.0
25 migraine with or without aura 1 10.0
26 teratoma, ovarian 10.0
27 stroke, ischemic 10.0
28 amusia 10.0
29 anosognosia 10.0
30 form agnosia 10.0
31 simultanagnosia 10.0
32 agraphia 10.0
33 color blindness 10.0
34 lateral sclerosis 10.0
35 teratoma 10.0
36 ovarian germ cell teratoma 10.0
37 cerebrovascular disease 10.0
38 brain injury 10.0
39 head injury 10.0
40 traumatic brain injury 10.0
41 alzheimer disease 9.9
42 cerebral amyloid angiopathy, cst3-related 9.9
43 creutzfeldt-jakob disease 9.9
44 optic atrophy with or without deafness, ophthalmoplegia, myopathy, ataxia, and neuropathy 9.9
45 huntington disease 9.9
46 attention deficit-hyperactivity disorder 9.9
47 polykaryocytosis inducer 9.9
48 schizophrenia 9.9
49 tune deafness 9.9
50 hydrocephalus, congenital, 1 9.9

Graphical network of the top 20 diseases related to Prosopagnosia:



Diseases related to Prosopagnosia

Symptoms & Phenotypes for Prosopagnosia

UMLS symptoms related to Prosopagnosia:


visual agnosia

Drugs & Therapeutics for Prosopagnosia

Drugs for Prosopagnosia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oxytocin Approved, Vet_approved Early Phase 1 50-56-6 439302 53477758
2 Oxytocics Early Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Behavioral and Neural Effects of Oxytocin on Face Perception in Congenital Prosopagnosia Suspended NCT02091817 Early Phase 1 Oxytocin;Placebo

Search NIH Clinical Center for Prosopagnosia

Cochrane evidence based reviews: prosopagnosia

Genetic Tests for Prosopagnosia

Anatomical Context for Prosopagnosia

MalaCards organs/tissues related to Prosopagnosia:

41
Brain, Testes, Cortex, Eye, Temporal Lobe, Occipital Lobe, Bone Marrow

Publications for Prosopagnosia

Articles related to Prosopagnosia:

(show top 50) (show all 811)
# Title Authors PMID Year
1
Developmental prosopagnosia with concurrent topographical difficulties: A case report and virtual reality training programme. 38
29206082 2019
2
The Scanpaths of Subjects with Developmental Prosopagnosia during a Face Memory Task. 38
31382482 2019
3
Eye movements and retinotopic tuning in developmental prosopagnosia. 38
31426085 2019
4
The domain-specificity of face matching impairments in 40 cases of developmental prosopagnosia. 38
31351346 2019
5
Objective Patterns of Face Recognition Deficits in 165 Adults with Self-Reported Developmental Prosopagnosia. 38
31174381 2019
6
Self-ratings of face recognition ability are influenced by gender but not prosopagnosia severity. 38
30730191 2019
7
Coping strategies for developmental prosopagnosia. 38
31161896 2019
8
Caricaturing as a general method to improve poor face recognition: Evidence from low-resolution images, other-race faces, and older adults. 38
30321022 2019
9
Self-reported face recognition is highly valid, but alone is not highly discriminative of prosopagnosia-level performance on objective assessments. 38
30761463 2019
10
Multifaceted Integration: Memory for Faces Is Subserved by Widespread Connections between Visual, Memory, Auditory, and Social Networks. 38
31036762 2019
11
Face Recognition. 38
31144153 2019
12
Atypical non-progressive semantic impairment following allogeneic bone marrow transplantation in a patient with Waldenström's macroglobulinemia: A case report. 38
30468103 2019
13
First the nose, last the eyes in congenital prosopagnosia: Look like your father looks. 38
31094554 2019
14
Does developmental prosopagnosia impair identification of other-ethnicity faces? 38
31071553 2019
15
Evidence of taxonomy for Developmental Topographical Disorientation: Developmental Landmark Agnosia Case 1. 38
29192795 2019
16
Difficulty differentiating a case of posterior cortical atrophy from a psychogenic disturbance of vision. 38
30997705 2019
17
Storage, Degradation, and New Connectivity of Face-Related Semantic Memory in Alzheimer's Disease. 38
31007428 2019
18
Facing the facts: Naive participants have only moderate insight into their face recognition and face perception abilities. 38
29706121 2019
19
A Computational Model of Visual Recognition Memory via Grid Cells. 38
30853437 2019
20
Self-face and self-body advantages in congenital prosopagnosia: evidence for a common mechanism. 38
30542755 2019
21
Is developmental prosopagnosia best characterised as an apperceptive or mnemonic condition? 38
30502377 2019
22
Object recognition in acquired and developmental prosopagnosia. 38
30947609 2019
23
Evaluating object recognition ability in developmental prosopagnosia using the Cambridge Car Memory Test. 38
30973292 2019
24
Perception of musical pitch in developmental prosopagnosia. 38
30625291 2019
25
Transient Dyschromatopsia, Static Form Agnosia, and Prosopagnosia Observed in a Patient with Anti-NMDA Receptor Encephalitis. 38
31061739 2019
26
Developmental Cognitive Deficits: A Historical Overview of Early Cases. 38
31220836 2019
27
Subjective assessment for super recognition: an evaluation of self-report methods in civilian and police participants. 38
30723622 2019
28
Suicide as a result of stereotypic behaviour in a case with semantic dementia. 38
30058742 2019
29
Progress in perceptual research: the case of prosopagnosia. 38
31231507 2019
30
The hidden identity of faces: a case of lifelong prosopagnosia. 38
30670082 2019
31
System for Face Recognition under Different Facial Expressions Using a New Associative Hybrid Model Amαβ-KNN for People with Visual Impairment or Prosopagnosia. 38
30704082 2019
32
Tests of whole upright face processing in prosopagnosia: A literature review. 38
30389553 2018
33
Normative accuracy and response time data for the computerized Benton Facial Recognition Test (BFRT-c). 38
29549569 2018
34
Delayed processing of global shape information is associated with weaker top-down effects in developmental prosopagnosia. 38
30204050 2018
35
Holistic face perception is impaired in developmental prosopagnosia. 38
30165324 2018
36
Multimodal face and voice recognition disorders in a case with unilateral right anterior temporal lobe atrophy. 38
30080078 2018
37
[Delusional Misidentification Syndromes in Organic Brain Disorders]. 38
30416111 2018
38
The cortical face network of the prosopagnosic patient PS with fast periodic stimulation in fMRI. 38
30545601 2018
39
Visual crowding in pure alexia and acquired prosopagnosia. 38
29902952 2018
40
The Visual Agnosias and Related Disorders. 38
28945627 2018
41
Damasio's error - Prosopagnosia with intact within-category object recognition. 38
29845731 2018
42
[18F]THK-5351 PET imaging in early-stage semantic variant primary progressive aphasia: a report of two cases and a literature review. 38
30089453 2018
43
The contribution of facial dynamics to subtle expression recognition in typical viewers and developmental visual agnosia. 38
29723598 2018
44
Developmental prosopagnosics have widespread selectivity reductions across category-selective visual cortex. 38
29941554 2018
45
Decisional space determines saccadic reaction times in healthy observers and acquired prosopagnosia. 38
29749293 2018
46
Emotion Recognition and Psychological Comorbidity in Friedreich's Ataxia. 38
29327279 2018
47
The Original Social Network: White Matter and Social Cognition. 38
29628441 2018
48
Teaching NeuroImages: Prosopagnosia heralding anti-NMDA receptor encephalitis. 38
29807927 2018
49
People with and without prosopagnosia have insight into their face recognition ability. 38
28513322 2018
50
Inversion effects for faces and objects in developmental prosopagnosia: A case series analysis. 38
29596857 2018

Variations for Prosopagnosia

Expression for Prosopagnosia

Search GEO for disease gene expression data for Prosopagnosia.

Pathways for Prosopagnosia

Pathways related to Prosopagnosia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.39 KCNK5 KCNK3 AK5
2
Show member pathways
11.05 KCNK5 KCNK3

GO Terms for Prosopagnosia

Biological processes related to Prosopagnosia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 potassium ion transport GO:0006813 8.96 KCNK5 KCNK3
2 potassium ion transmembrane transport GO:0071805 8.62 KCNK5 KCNK3

Molecular functions related to Prosopagnosia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 potassium channel activity GO:0005267 8.96 KCNK5 KCNK3
2 potassium ion leak channel activity GO:0022841 8.62 KCNK5 KCNK3

Sources for Prosopagnosia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
Content
Loading form....