MCID: PRS013
MIFTS: 36

Prosopagnosia

Categories: Eye diseases, Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Prosopagnosia

MalaCards integrated aliases for Prosopagnosia:

Name: Prosopagnosia 12 53 43 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:4970
MeSH 43 D020238
NCIt 49 C85031
SNOMED-CT 67 18358003
ICD10 32 R48.3
UMLS 71 C0234512

Summaries for Prosopagnosia

NINDS : 53 Prosopagnosia is a neurological disorder characterized by the inability to recognize faces.  Prosopagnosia is also known as face blindness or facial agnosia.  The term prosopagnosia comes from the Greek words for “face” and “lack of knowledge.”   Depending upon the degree of impairment, some people with prosopagnosia may only have difficulty recognizing a familiar face; others will be unable to discriminate between unknown faces, while still others may not even be able to distinguish a face as being different from an object.  Some people with the disorder are unable to recognize their own face.  Prosopagnosia is not related to memory dysfunction, memory loss, impaired vision, or learning disabilities.  Prosopagnosia is thought to be the result of abnormalities, damage, or impairment in the right fusiform gyrus, a fold in the brain that appears to coordinate the neural systems that control facial perception and memory.  Prosopagnosia can result from stroke, traumatic brain injury, or certain neurodegenerative diseases.  In some cases it is a congenital disorder, present at birth in the absence of any brain damage.  Congenital prosopagnosia appears to run in families, which makes it likely to be the result of a genetic mutation or deletion.  Some degree of prosopagnosia is often present in children with autism and Asperger’s syndrome, and may be the cause of their impaired social development.

MalaCards based summary : Prosopagnosia is related to visual agnosia and amusia, and has symptoms including visual agnosia An important gene associated with Prosopagnosia is OXTR (Oxytocin Receptor). The drugs Oxytocin and Oxytocics have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and testes, and related phenotypes are behavior/neurological and nervous system

Disease Ontology : 12 An agnosia that results in the loss of the ability to consciously recognize familiar faces.

Wikipedia : 74 Prosopagnosia, also called face blindness, is a cognitive disorder of face perception in which the... more...

Related Diseases for Prosopagnosia

Diseases in the Prosopagnosia family:

Prosopagnosia, Hereditary

Diseases related to Prosopagnosia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 142)
# Related Disease Score Top Affiliating Genes
1 visual agnosia 31.4 MAPT GRN
2 amusia 30.6 KCNK3 GRN
3 apraxia 30.4 MAPT GRN C9orf72
4 corticobasal degeneration 30.2 TARDBP MAPT
5 suppression amblyopia 30.2 TNFRSF10C HNMT
6 lateral sclerosis 30.1 TARDBP CHMP2B C9orf72
7 agraphia 29.9 TARDBP MAPT GRN C9orf72
8 dementia 29.9 TARDBP MAPT GRN CHMP2B C9orf72
9 movement disease 29.9 TARDBP MAPT C9orf72
10 semantic dementia 29.8 TARDBP MAPT GRN CHMP2B C9orf72
11 integrative agnosia 29.7 KLK4 KCNK5 KCNK3
12 associative agnosia 29.7 TARDBP MAPT GRN CHMP2B C9orf72
13 alexia 29.6 MAPT KCNK5 KCNK3 GRN ASPRV1
14 aphasia 29.6 TARDBP MAPT GRN CHMP2B C9orf72
15 dysgraphia 29.6 TARDBP MAPT GRN CHMP2B C9orf72
16 motor neuron disease 29.6 TARDBP MAPT GRN C9orf72
17 frontotemporal dementia 29.6 TARDBP MAPT GRN CHMP2B C9orf72
18 amyotrophic lateral sclerosis 1 29.5 TARDBP MAPT GRN CHMP2B C9orf72
19 nominal aphasia 29.3 TARDBP MAPT GRN CHMP2B C9orf72
20 speech and communication disorders 28.4 TNFRSF10C TARDBP MAPT GRN CHMP2B C9orf72
21 prosopagnosia, hereditary 12.9
22 agnosia 10.8
23 yemenite deaf-blind hypopigmentation syndrome 10.5
24 frontotemporal lobar degeneration with tdp43 inclusions, grn-related 10.4 MAPT GRN
25 akinetic mutism 10.3 TARDBP MAPT
26 postencephalitic parkinson disease 10.3 TARDBP MAPT
27 autism spectrum disorder 10.3
28 dyslexia 10.3
29 achromatopsia 10.2
30 progressive bulbar palsy 10.2 TARDBP C9orf72
31 arteriolosclerosis 10.2 TARDBP MAPT
32 amyotrophic lateral sclerosis 19 10.2 TARDBP C9orf72
33 amnestic disorder 10.2
34 vascular disease 10.2
35 capgras syndrome 10.2
36 encephalitis 10.2
37 animal phobia 10.2 TNFRSF10C ASPRV1
38 amyotrophic lateral sclerosis 12 10.2 TARDBP CHMP2B
39 amyotrophic lateral sclerosis type 15 10.2 CHMP2B C9orf72
40 amyotrophic lateral sclerosis 11 10.2 TARDBP CHMP2B
41 amyotrophic lateral sclerosis type 14 10.2 CHMP2B C9orf72
42 paraphilia disorder 10.2 GRN ASPRV1
43 amyotrophic lateral sclerosis 10 with or without frontotemporal dementia 10.1 TARDBP C9orf72
44 asperger syndrome 10.1
45 arteriovenous malformation 10.1
46 cortical blindness 10.1
47 amyotrophic lateral sclerosis 16, juvenile 10.1 CHMP2B C9orf72
48 amyotrophic lateral sclerosis type 6 10.1 TARDBP C9orf72
49 echolalia 10.1 MAPT GRN C9orf72
50 amyotrophic lateral sclerosis 4, juvenile 10.1 TARDBP C9orf72

Graphical network of the top 20 diseases related to Prosopagnosia:



Diseases related to Prosopagnosia

Symptoms & Phenotypes for Prosopagnosia

UMLS symptoms related to Prosopagnosia:


visual agnosia

MGI Mouse Phenotypes related to Prosopagnosia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.81 C9orf72 GPSM2 GRN HNMT KCNK3 MAPT
2 nervous system MP:0003631 9.65 C9orf72 CHMP2B GPSM2 GRN HNMT KCNK3
3 no phenotypic analysis MP:0003012 9.17 C9orf72 GPSM2 GRN KCNK3 MAPT OXTR

Drugs & Therapeutics for Prosopagnosia

Drugs for Prosopagnosia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oxytocin Approved, Vet_approved Early Phase 1 50-56-6 439302 53477758
2 Oxytocics Early Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Behavioral and Neural Effects of Oxytocin on Face Perception in Congenital Prosopagnosia Suspended NCT02091817 Early Phase 1 Oxytocin;Placebo

Search NIH Clinical Center for Prosopagnosia

Cochrane evidence based reviews: prosopagnosia

Genetic Tests for Prosopagnosia

Anatomical Context for Prosopagnosia

MalaCards organs/tissues related to Prosopagnosia:

40
Brain, Eye, Testes, Cortex, Temporal Lobe, Bone, Occipital Lobe

Publications for Prosopagnosia

Articles related to Prosopagnosia:

(show top 50) (show all 823)
# Title Authors PMID Year
1
Difficulty differentiating a case of posterior cortical atrophy from a psychogenic disturbance of vision. 61
30997705 2020
2
Posterior primary progressive prosopagnosia: Structural and molecular imaging. 61
31964687 2020
3
Search for Face Identity or Expression: Set Size Effects in Developmental Prosopagnosia. 61
31905091 2020
4
Atypical holistic processing of facial identity and expression in a case of acquired prosopagnosia. 61
31983272 2020
5
Bayesian regression-based developmental norms for the Benton Facial Recognition Test in males and females. 61
31907754 2020
6
Multi-Item Discriminability Pattern to Faces in Developmental Prosopagnosia Reveals Distinct Mechanisms of Face Processing. 61
31813985 2019
7
The discrimination of facial sex in developmental prosopagnosia. 61
31836836 2019
8
Looking beyond the face area: lesion network mapping of prosopagnosia. 61
31740940 2019
9
A case of aneurysmal subarchnoid haemorrhage and superficial siderosis complicated by prospagnosia, simultagnosia and alexia without agraphia. 61
31790281 2019
10
Training face perception in developmental prosopagnosia through perceptual learning. 61
31541661 2019
11
The domain-specificity of face matching impairments in 40 cases of developmental prosopagnosia. 61
31351346 2019
12
Pearls & Oy-sters: Isolated prosopagnosia as the presenting complaint in glioblastoma: The face of deception. 61
31570639 2019
13
Does developmental prosopagnosia impair identification of other-ethnicity faces? 61
31071553 2019
14
The cortical face network of the prosopagnosic patient PS with fast periodic stimulation in fMRI. 61
30545601 2019
15
Developmental prosopagnosia with concurrent topographical difficulties: A case report and virtual reality training programme. 61
29206082 2019
16
First the nose, last the eyes in congenital prosopagnosia: Look like your father looks. 61
31094554 2019
17
Visual perceptual disorders in Alzheimer's disease. 61
31449049 2019
18
The Scanpaths of Subjects with Developmental Prosopagnosia during a Face Memory Task. 61
31382482 2019
19
Eye movements and retinotopic tuning in developmental prosopagnosia. 61
31426085 2019
20
Coping strategies for developmental prosopagnosia. 61
31161896 2019
21
Objective Patterns of Face Recognition Deficits in 165 Adults with Self-Reported Developmental Prosopagnosia. 61
31174381 2019
22
Self-ratings of face recognition ability are influenced by gender but not prosopagnosia severity. 61
30730191 2019
23
Caricaturing as a general method to improve poor face recognition: Evidence from low-resolution images, other-race faces, and older adults. 61
30321022 2019
24
Multifaceted Integration: Memory for Faces Is Subserved by Widespread Connections between Visual, Memory, Auditory, and Social Networks. 61
31036762 2019
25
Self-reported face recognition is highly valid, but alone is not highly discriminative of prosopagnosia-level performance on objective assessments. 61
30761463 2019
26
Face Recognition. 61
31144153 2019
27
Atypical non-progressive semantic impairment following allogeneic bone marrow transplantation in a patient with Waldenström's macroglobulinemia: A case report. 61
30468103 2019
28
Storage, Degradation, and New Connectivity of Face-Related Semantic Memory in Alzheimer's Disease. 61
31007428 2019
29
Evidence of taxonomy for Developmental Topographical Disorientation: Developmental Landmark Agnosia Case 1. 61
29192795 2019
30
Facing the facts: Naive participants have only moderate insight into their face recognition and face perception abilities. 61
29706121 2019
31
A Computational Model of Visual Recognition Memory via Grid Cells. 61
30853437 2019
32
Self-face and self-body advantages in congenital prosopagnosia: evidence for a common mechanism. 61
30542755 2019
33
Is developmental prosopagnosia best characterised as an apperceptive or mnemonic condition? 61
30502377 2019
34
Object recognition in acquired and developmental prosopagnosia. 61
30947609 2019
35
Evaluating object recognition ability in developmental prosopagnosia using the Cambridge Car Memory Test. 61
30973292 2019
36
Perception of musical pitch in developmental prosopagnosia. 61
30625291 2019
37
Transient Dyschromatopsia, Static Form Agnosia, and Prosopagnosia Observed in a Patient with Anti-NMDA Receptor Encephalitis. 61
31061739 2019
38
Cognitive and Behavioral Profiles of Left and Right Semantic Dementia: Differential Diagnosis with Behavioral Variant Frontotemporal Dementia and Alzheimer's Disease. 61
31683488 2019
39
Suicide as a result of stereotypic behaviour in a case with semantic dementia. 61
30058742 2019
40
Developmental Cognitive Deficits: A Historical Overview of Early Cases. 61
31220836 2019
41
Subjective assessment for super recognition: an evaluation of self-report methods in civilian and police participants. 61
30723622 2019
42
The hidden identity of faces: a case of lifelong prosopagnosia. 61
30670082 2019
43
Progress in perceptual research: the case of prosopagnosia. 61
31231507 2019
44
System for Face Recognition under Different Facial Expressions Using a New Associative Hybrid Model Amαβ-KNN for People with Visual Impairment or Prosopagnosia. 61
30704082 2019
45
Normative accuracy and response time data for the computerized Benton Facial Recognition Test (BFRT-c). 61
29549569 2018
46
Tests of whole upright face processing in prosopagnosia: A literature review. 61
30389553 2018
47
Delayed processing of global shape information is associated with weaker top-down effects in developmental prosopagnosia. 61
30204050 2018
48
Holistic face perception is impaired in developmental prosopagnosia. 61
30165324 2018
49
Multimodal face and voice recognition disorders in a case with unilateral right anterior temporal lobe atrophy. 61
30080078 2018
50
[Delusional Misidentification Syndromes in Organic Brain Disorders]. 61
30416111 2018

Variations for Prosopagnosia

Expression for Prosopagnosia

Search GEO for disease gene expression data for Prosopagnosia.

Pathways for Prosopagnosia

GO Terms for Prosopagnosia

Cellular components related to Prosopagnosia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 9.93 TNFRSF10C RCE1 OXTR MAPT KCNK5 KCNK3
2 cell GO:0005623 9.17 OXTR MAPT KCNK3 GRN GPSM2 CHMP2B
3 main axon GO:0044304 8.96 MAPT C9orf72

Biological processes related to Prosopagnosia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 stabilization of membrane potential GO:0030322 8.96 KCNK5 KCNK3
2 stress granule assembly GO:0034063 8.62 MAPT C9orf72

Molecular functions related to Prosopagnosia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 potassium ion leak channel activity GO:0022841 8.62 KCNK5 KCNK3

Sources for Prosopagnosia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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