Prostate Adenoid Cystic Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Prostate Adenoid Cystic Carcinoma

MalaCards integrated aliases for Prostate Adenoid Cystic Carcinoma:

Name: Prostate Adenoid Cystic Carcinoma ¹² ¹⁵ ⁷³

Adenoid Cystic Carcinoma of the Prostate ¹²

Adenoid Cystic Carcinoma of Prostate ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:4868

NCIt ⁵⁰ C5539

UMLS ⁷³ C1335502

Sources

Summaries for Prostate Adenoid Cystic Carcinoma

MalaCards based summary : Prostate Adenoid Cystic Carcinoma, also known as adenoid cystic carcinoma of the prostate, is related to spitz nevus and apocrine adenoma, and has symptoms including pain An important gene associated with Prostate Adenoid Cystic Carcinoma is HRAS (HRas Proto-Oncogene, GTPase), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. Affiliated tissues include prostate.

Sources

Related Diseases for Prostate Adenoid Cystic Carcinoma

Diseases related to Prostate Adenoid Cystic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)

#	Related Disease	Score	Top Affiliating Genes
1	spitz nevus	10.4	HRAS LRRC56
2	apocrine adenoma	10.3	HRAS PIK3CA
3	pulmonic stenosis	10.3	HRAS LRRC56
4	aggressive digital papillary adenocarcinoma	10.3	HRAS PIK3CA
5	ethmoid sinus cancer	10.3	HRAS PIK3CA
6	ethmoid sinus adenocarcinoma	10.3	HRAS PIK3CA
7	lung adenoid cystic carcinoma	10.3	HRAS PIK3CA
8	nevus, epidermal	10.2	HRAS PIK3CA
9	acneiform dermatitis	10.2	HRAS PIK3CA
10	adenosquamous cell lung carcinoma	10.2	HRAS PIK3CA
11	ovarian cancer 1	10.2	HRAS PIK3CA
12	malignant ovarian surface epithelial-stromal neoplasm	10.2	HRAS PIK3CA
13	ovary epithelial cancer	10.2	HRAS PIK3CA
14	serous cystadenocarcinoma	10.2	HRAS PIK3CA
15	cystadenocarcinoma	10.1	HRAS PIK3CA
16	female reproductive organ cancer	10.1	HRAS PIK3CA
17	prostate transitional cell carcinoma	10.1	KLK3 PIK3CA
18	renal cell carcinoma, papillary, 1	10.0	HRAS PIK3CA
19	respiratory system cancer	10.0	HRAS PIK3CA
20	adenoid cystic carcinoma	9.9
21	prostatitis	9.9
22	adenoiditis	9.9
23	secondary hypertrophic osteoarthropathy	9.9	HRAS POMC
24	urinary tract obstruction	9.9	KLK3 PIK3CA
25	gastrointestinal system cancer	9.8	HRAS PIK3CA
26	cell type cancer	9.8	HRAS KLK3
27	skin squamous cell carcinoma	9.8	HRAS LRRC56 PIK3CA
28	ovarian serous cystadenocarcinoma	9.8	HRAS LRRC56 PIK3CA
29	uterine carcinosarcoma	9.8	HRAS LRRC56 PIK3CA
30	cell type benign neoplasm	9.7	HRAS POMC
31	tuberculous epididymitis	9.7	KLK3 POMC
32	suprasellar meningioma	9.7	KLK3 POMC
33	withdrawal disorder	9.6	KLK3 POMC
34	suppression of tumorigenicity 12	9.6	HRAS KLK3 PIK3CA
35	bladder urothelial carcinoma	9.6	HRAS KLK3 PIK3CA
36	gynecomastia	9.6	KLK3 POMC
37	pilocytic astrocytoma	9.5	HRAS PIK3CA
38	urinary system disease	9.4	KLK3 POMC
39	thyroid cancer, nonmedullary, 2	9.3	HRAS PIK3CA POMC
40	adrenocortical carcinoma, hereditary	9.2	PIK3CA POMC
41	prostate squamous cell carcinoma	9.1	HRAS KLK3 LRRC56 PIK3CA

Graphical network of the top 20 diseases related to Prostate Adenoid Cystic Carcinoma:

Sources

Symptoms & Phenotypes for Prostate Adenoid Cystic Carcinoma

UMLS symptoms related to Prostate Adenoid Cystic Carcinoma:

pain

Sources

Drugs & Therapeutics for Prostate Adenoid Cystic Carcinoma

Search Clinical Trials , NIH Clinical Center for Prostate Adenoid Cystic Carcinoma

Sources

Genetic Tests for Prostate Adenoid Cystic Carcinoma

Sources

Anatomical Context for Prostate Adenoid Cystic Carcinoma

MalaCards organs/tissues related to Prostate Adenoid Cystic Carcinoma:

⁴¹

Prostate

Sources

Publications for Prostate Adenoid Cystic Carcinoma

Articles related to Prostate Adenoid Cystic Carcinoma:

#	Title	Authors	Year
1	Adenoid cystic carcinoma of the prostate: case report on a rare entity and review of the literature. ( 21440997 )	Ahuja A....Ray R.	2011

Sources

Genes for Prostate Adenoid Cystic Carcinoma

Genes related to Prostate Adenoid Cystic Carcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	17.82	GeneCards inferred via : Variants (show sections)
2	LRRC56	Leucine Rich Repeat Containing 56	Protein Coding	17.82	GeneCards inferred via : Variants (show sections)
3	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	17.82	GeneCards inferred via : Variants (show sections)
4	KLK3	Kallikrein Related Peptidase 3	Protein Coding	15.16	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	POMC	Proopiomelanocortin	Protein Coding	13.37	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	NDUFAB1	NADH:Ubiquinone Oxidoreductase Subunit AB1	Protein Coding	6.04	DISEASES inferred ¹⁵

Sources

Variations for Prostate Adenoid Cystic Carcinoma

Sources

Expression for Prostate Adenoid Cystic Carcinoma

Search GEO for disease gene expression data for Prostate Adenoid Cystic Carcinoma.

Sources

Pathways for Prostate Adenoid Cystic Carcinoma

Pathways related to Prostate Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

(show all 19)

#	Super pathways	Score	Top Affiliating Genes
1	Endometrial cancer ³⁷ Show member pathways Acute myeloid leukemia ³⁷ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁶ Chronic myeloid leukemia ³⁷ Colorectal cancer ³⁷ Pancreatic cancer ³⁷ Prostate cancer ³⁷ Signal transduction PTEN pathway ²² Thyroid cancer ³⁷	12.51	HRAS KLK3 PIK3CA
2	Pathways in cancer ³⁷	12.44	HRAS KLK3 PIK3CA
3	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants ⁶⁶ Show member pathways Constitutive Signaling by EGFRvIII ⁶⁶ Signaling by EGFR in Cancer ⁶⁶ Signaling by EGFRvIII in Cancer ⁶⁶ Signaling by Ligand-Responsive EGFR Variants in Cancer ⁶⁶	11.54	HRAS PIK3CA
4	Signaling events mediated by VEGFR1 and VEGFR2 ¹ Show member pathways VEGFR1 specific signals ¹	11.53	HRAS PIK3CA
5	FGFR1 mutant receptor activation ⁶⁶ Show member pathways Signaling by cytosolic FGFR1 fusion mutants ⁶⁶ Signaling by FGFR1 in disease ⁶⁶ Signaling by plasma membrane FGFR1 fusions ⁶⁶	11.51	HRAS PIK3CA
6	VEGF Pathway (Tocris) ⁷² Show member pathways Sorafenib Pharmacodynamics ⁶¹	11.46	HRAS PIK3CA
7	Human Thyroid Stimulating Hormone (TSH) signaling pathway ¹	11.36	HRAS PIK3CA
8	Pathways Affected in Adenoid Cystic Carcinoma ¹	11.33	HRAS PIK3CA
9	Central carbon metabolism in cancer ³⁷	11.31	HRAS PIK3CA
10	PDGFR-beta signaling pathway ¹	11.21	HRAS PIK3CA
11	Insulin Pathway ¹	11.09	HRAS PIK3CA
12	G-protein signaling_H-RAS regulation pathway ²²	11	HRAS PIK3CA
13	Signaling events regulated by Ret tyrosine kinase ¹	10.98	HRAS PIK3CA
14	Transcription Androgen Receptor nuclear signaling ²² Show member pathways Translation Non-genomic (rapid) action of Androgen Receptor ²²	10.96	HRAS KLK3 PIK3CA
15	a6b1 and a6b4 Integrin signaling ¹	10.86	HRAS PIK3CA
16	Development_Leptin signaling via JAK/STAT and MAPK cascades ²² Show member pathways phospho-PLA2 pathway ⁶⁶	10.8	HRAS POMC
17	PI3K-AKT-mTOR signaling pathway and therapeutic opportunities ¹	10.73	HRAS PIK3CA
18	IGF1 pathway ¹	10.6	HRAS PIK3CA
19	Nongenotropic Androgen signaling ¹	10.21	HRAS PIK3CA

Sources

GO Terms for Prostate Adenoid Cystic Carcinoma

Biological processes related to Prostate Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	epidermal growth factor receptor signaling pathway	GO:0007173	8.96	HRAS PIK3CA
2	ERBB2 signaling pathway	GO:0038128	8.62	HRAS PIK3CA

Sources

Sources for Prostate Adenoid Cystic Carcinoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia