MCID: PRS007
MIFTS: 24

Prostate Calculus

Categories: Reproductive diseases

Aliases & Classifications for Prostate Calculus

MalaCards integrated aliases for Prostate Calculus:

Name: Prostate Calculus 12 15
Calculus of Prostate 12 70 32
Prostatic Lithiasis 12
Stone of Prostate 12
Prostatic Stone 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13689
ICD9CM 34 602.0
NCIt 50 C26936
SNOMED-CT 67 155934005
ICD10 32 N42.0
UMLS 70 C0149525

Summaries for Prostate Calculus

MalaCards based summary : Prostate Calculus, also known as calculus of prostate, is related to prostate adenoid cystic carcinoma and prostate leiomyoma. An important gene associated with Prostate Calculus is KLK3 (Kallikrein Related Peptidase 3), and among its related pathways/superpathways are DNA Double-Strand Break Repair and Nucleotide excision repair. Affiliated tissues include prostate, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation

Related Diseases for Prostate Calculus

Graphical network of the top 20 diseases related to Prostate Calculus:



Diseases related to Prostate Calculus

Symptoms & Phenotypes for Prostate Calculus

GenomeRNAi Phenotypes related to Prostate Calculus according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 9.26 CHD1L PAXIP1 PNKP XPC
2 Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation GR00016-A 8.8 CA9 PAXIP1 XPC

Drugs & Therapeutics for Prostate Calculus

Search Clinical Trials , NIH Clinical Center for Prostate Calculus

Genetic Tests for Prostate Calculus

Anatomical Context for Prostate Calculus

MalaCards organs/tissues related to Prostate Calculus:

40
Prostate

Publications for Prostate Calculus

Articles related to Prostate Calculus:

# Title Authors PMID Year
1
Minnelide Inhibits Androgen Dependent, Castration Resistant Prostate Cancer Growth by Decreasing Expression of Androgen Receptor Full Length and Splice Variants. 61
28144973 2017

Variations for Prostate Calculus

Expression for Prostate Calculus

Search GEO for disease gene expression data for Prostate Calculus.

Pathways for Prostate Calculus

GO Terms for Prostate Calculus

Cellular components related to Prostate Calculus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.17 XPC PNKP PAXIP1 KLK3 CHD1L CA9

Biological processes related to Prostate Calculus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleotide-excision repair, preincision complex assembly GO:0006294 9.37 XPC CHD1L
2 global genome nucleotide-excision repair GO:0070911 9.32 XPC CHD1L
3 nucleotide-excision repair, DNA duplex unwinding GO:0000717 9.26 XPC CHD1L
4 cellular response to DNA damage stimulus GO:0006974 9.26 XPC PNKP PAXIP1 CHD1L
5 regulation of systemic arterial blood pressure GO:0003073 9.16 KLK3 AR
6 DNA repair GO:0006281 8.92 XPC PNKP PAXIP1 CHD1L

Molecular functions related to Prostate Calculus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 damaged DNA binding GO:0003684 8.62 XPC PNKP

Sources for Prostate Calculus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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