Prostate Calculus disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Prostate Calculus

MalaCards integrated aliases for Prostate Calculus:

Name: Prostate Calculus ¹² ¹⁵

Calculus of Prostate ¹² ⁷⁰ ³²

Prostatic Lithiasis ¹²

Stone of Prostate ¹²

Prostatic Stone ¹²

Classifications:

MalaCards categories:
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Diseases of the genitourinary system

Diseases of male genital organs

Other disorders of prostate

Calculus of prostate

External Ids:

Disease Ontology ¹² DOID:13689

ICD9CM ³⁴ 602.0

NCIt ⁵⁰ C26936

SNOMED-CT ⁶⁷ 155934005

ICD10 ³² N42.0

UMLS ⁷⁰ C0149525

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Summaries for Prostate Calculus

MalaCards based summary : Prostate Calculus, also known as calculus of prostate, is related to prostate adenoid cystic carcinoma and prostate leiomyoma. An important gene associated with Prostate Calculus is KLK3 (Kallikrein Related Peptidase 3), and among its related pathways/superpathways are DNA Double-Strand Break Repair and Nucleotide excision repair. Affiliated tissues include prostate, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation

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Related Diseases for Prostate Calculus

Diseases related to Prostate Calculus via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 22)

#	Related Disease	Score	Top Affiliating Genes
1	prostate adenoid cystic carcinoma	10.1	KLK3 AR
2	prostate leiomyoma	10.1	KLK3 AR
3	nodular prostate	10.1	KLK3 AR
4	bronchiectasis 3	10.1	KLK3 AR
5	prostatic acinar adenocarcinoma	10.1	KLK3 AR
6	prostatic hyperplasia, benign	10.1	KLK3 AR
7	prostate neuroendocrine neoplasm	10.1	KLK3 AR
8	prostate transitional cell carcinoma	10.1	KLK3 AR
9	male reproductive organ benign neoplasm	10.1	KLK3 AR
10	prostatic adenoma	10.1	KLK3 AR
11	withdrawal disorder	10.1	KLK3 AR
12	androgenic alopecia	10.0	KLK3 AR
13	prostatic hypertrophy	10.0	KLK3 AR
14	lymph node carcinoma	10.0	KLK3 AR
15	sexual disorder	10.0	KLK3 AR
16	gynecomastia	10.0	KLK3 AR
17	female breast cancer	10.0	KLK3 AR
18	small cell carcinoma	9.9	KLK3 AR
19	prostatitis	9.9
20	suppression of tumorigenicity 12	9.9	KLK3 AR
21	ductal carcinoma in situ	9.7	CA9 AR
22	skin carcinoma	9.5	XPC KLK3 AR

Comorbidity relations with Prostate Calculus via Phenotypic Disease Network (PDN):

Bladder Neck Obstruction	Prostate Cancer
Prostatic Hypertrophy	Prostatitis
Urethral Stricture	Urinary Tract Obstruction

Graphical network of the top 20 diseases related to Prostate Calculus:

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Symptoms & Phenotypes for Prostate Calculus

GenomeRNAi Phenotypes related to Prostate Calculus according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-3	9.26	CHD1L PAXIP1 PNKP XPC
2	Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation	GR00016-A	8.8	CA9 PAXIP1 XPC

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Drugs & Therapeutics for Prostate Calculus

Search Clinical Trials , NIH Clinical Center for Prostate Calculus

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Genetic Tests for Prostate Calculus

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Anatomical Context for Prostate Calculus

MalaCards organs/tissues related to Prostate Calculus:

⁴⁰

Prostate

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Publications for Prostate Calculus

Articles related to Prostate Calculus:

#	Title	Authors	PMID	Year
1	Minnelide Inhibits Androgen Dependent, Castration Resistant Prostate Cancer Growth by Decreasing Expression of Androgen Receptor Full Length and Splice Variants. ⁶¹	Isharwal S...Konety B	28144973	2017

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Genes for Prostate Calculus

Genes related to Prostate Calculus (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	KLK3	Kallikrein Related Peptidase 3	Protein Coding	5.69	DISEASES inferred ¹⁵
2	XPC	XPC Complex Subunit, DNA Damage Recognition And Repair Factor	Protein Coding	4.84	DISEASES inferred ¹⁵
3	AR	Androgen Receptor	Protein Coding	4.78	DISEASES inferred ¹⁵
4	CHD1L	Chromodomain Helicase DNA Binding Protein 1 Like	Protein Coding	4.52	DISEASES inferred ¹⁵
5	CA9	Carbonic Anhydrase 9	Protein Coding	4.47	DISEASES inferred ¹⁵
6	PAXIP1	PAX Interacting Protein 1	Protein Coding	4.47	DISEASES inferred ¹⁵
7	PNKP	Polynucleotide Kinase 3'-Phosphatase	Protein Coding	4.38	DISEASES inferred ¹⁵

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Variations for Prostate Calculus

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Expression for Prostate Calculus

Search GEO for disease gene expression data for Prostate Calculus.

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Pathways for Prostate Calculus

Pathways related to Prostate Calculus according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	DNA Double-Strand Break Repair ⁶⁵ Show member pathways Chk1/Chk2(Cds1) mediated inactivation of Cyclin B-Cdk1 complex ⁶⁵ DNA damage_DNA-damage-induced responses ²³ DNA Repair ⁶⁵ G2/M DNA damage checkpoint ⁶⁵ HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) ⁶⁵ HDR through MMEJ (alt-NHEJ) ⁶⁵ Homology Directed Repair ⁶⁵ Non-homologous end joining ¹ Non-homologous end-joining ³⁶ Processing of DNA double-strand break ends ⁶⁵	12.26	XPC PNKP PAXIP1 CHD1L
2	Nucleotide excision repair ³⁶ Show member pathways Dual Incision in GG-NER ⁶⁵ Nucleotide Excision Repair Pathway ⁶³	11.43	XPC CHD1L
3	Androgen receptor signaling pathway ¹	11.28	KLK3 AR
4	Coregulation of Androgen receptor activity ¹	11.01	KLK3 AR
5	Regulation of Androgen receptor activity ¹	10.85	KLK3 AR
6	FOXA1 transcription factor network ¹ Show member pathways FOXA transcription factor networks ¹	10.29	KLK3 AR

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GO Terms for Prostate Calculus

Cellular components related to Prostate Calculus according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nucleus	GO:0005634	9.17	XPC PNKP PAXIP1 KLK3 CHD1L CA9

Biological processes related to Prostate Calculus according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nucleotide-excision repair, preincision complex assembly	GO:0006294	9.37	XPC CHD1L
2	global genome nucleotide-excision repair	GO:0070911	9.32	XPC CHD1L
3	nucleotide-excision repair, DNA duplex unwinding	GO:0000717	9.26	XPC CHD1L
4	cellular response to DNA damage stimulus	GO:0006974	9.26	XPC PNKP PAXIP1 CHD1L
5	regulation of systemic arterial blood pressure	GO:0003073	9.16	KLK3 AR
6	DNA repair	GO:0006281	8.92	XPC PNKP PAXIP1 CHD1L

Molecular functions related to Prostate Calculus according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	damaged DNA binding	GO:0003684	8.62	XPC PNKP

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Sources for Prostate Calculus

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