CAPB
MCID: PRS131
MIFTS: 23

Prostate Cancer/brain Cancer Susceptibility (CAPB)

Categories: Cancer diseases, Genetic diseases, Neuronal diseases

Aliases & Classifications for Prostate Cancer/brain Cancer Susceptibility

MalaCards integrated aliases for Prostate Cancer/brain Cancer Susceptibility:

Name: Prostate Cancer/brain Cancer Susceptibility 57 29 6 39
Prostate Cancer/brain Cancer Susceptibility, Somatic 57
Pcbc 57
Capb 57

Classifications:



External Ids:

OMIM® 57 603688
MedGen 41 C1863600
SNOMED-CT via HPO 68 126951006 399068003

Summaries for Prostate Cancer/brain Cancer Susceptibility

MalaCards based summary : Prostate Cancer/brain Cancer Susceptibility, also known as prostate cancer/brain cancer susceptibility, somatic, is related to dermatitis, atopic and tularemia. An important gene associated with Prostate Cancer/brain Cancer Susceptibility is EPHB2 (EPH Receptor B2). Affiliated tissues include prostate, brain and kidney, and related phenotypes are neoplasm of the central nervous system and prostate cancer

More information from OMIM: 603688

Related Diseases for Prostate Cancer/brain Cancer Susceptibility

Diseases related to Prostate Cancer/brain Cancer Susceptibility via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 dermatitis, atopic 10.1
2 tularemia 10.1
3 prostate cancer, hereditary, 1 9.9
4 brain cancer 9.9

Symptoms & Phenotypes for Prostate Cancer/brain Cancer Susceptibility

Human phenotypes related to Prostate Cancer/brain Cancer Susceptibility:

31
# Description HPO Frequency HPO Source Accession
1 neoplasm of the central nervous system 31 HP:0100006
2 prostate cancer 31 HP:0012125

Clinical features from OMIM®:

603688 (Updated 05-Mar-2021)

Drugs & Therapeutics for Prostate Cancer/brain Cancer Susceptibility

Search Clinical Trials , NIH Clinical Center for Prostate Cancer/brain Cancer Susceptibility

Genetic Tests for Prostate Cancer/brain Cancer Susceptibility

Genetic tests related to Prostate Cancer/brain Cancer Susceptibility:

# Genetic test Affiliating Genes
1 Prostate Cancer/brain Cancer Susceptibility 29 EPHB2

Anatomical Context for Prostate Cancer/brain Cancer Susceptibility

MalaCards organs/tissues related to Prostate Cancer/brain Cancer Susceptibility:

40
Prostate, Brain, Kidney

Publications for Prostate Cancer/brain Cancer Susceptibility

Articles related to Prostate Cancer/brain Cancer Susceptibility:

(show top 50) (show all 186)
# Title Authors PMID Year
1
A common nonsense mutation in EphB2 is associated with prostate cancer risk in African American men with a positive family history. 57 6
16155194 2006
2
Nonsense-mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancer. 57 6
15300251 2004
3
PCAP is the major known prostate cancer predisposing locus in families from south and west Europe. 57
11313747 2001
4
Suggestive evidence for a site specific prostate cancer gene on chromosome 1p36. The CRC/BPG UK Familial Prostate Cancer Study Coordinators and Collaborators. The EU Biomed Collaborators. 57
11186936 2000
5
Evidence for a rare prostate cancer-susceptibility locus at chromosome 1p36. 57
10053012 1999
6
Covered vs bare stent for distal malignant biliary obstruction due to primary common biliary cancer. 61
33545967 2021
7
Measurement Invariance of the Persistent Complex Bereavement Disorder Checklist With Respect to Youth Gender, Race, Ethnicity, and Age. 61
32686226 2020
8
Comparative genomics of Alexander Fleming's original Penicillium isolate (IMI 15378) reveals sequence divergence of penicillin synthesis genes. 61
32973216 2020
9
Non-viral vector based gene transfection with human induced pluripotent stem cells derived cardiomyocytes. 61
31591436 2019
10
Screening and treatment to reduce severe hyperbilirubinaemia in infants in primary care (STARSHIP): a factorial stepped-wedge cluster randomised controlled trial protocol. 61
31005942 2019
11
Characterizing the Health-Related Quality of Life Burden of Overactive Bladder Using Disease-Specific Patient-Reported Outcome Measures: A Systematic Literature Review. 61
30715686 2019
12
Enhancing the production of cephalosporin C through modulating the autophagic process of Acremonium chrysogenum. 61
30424777 2018
13
A Myb transcription factor represses conidiation and cephalosporin C production in Acremonium chrysogenum. 61
29870835 2018
14
Power input effects on degeneration in prolonged penicillin chemostat cultures: A systems analysis at flux, residual glucose, metabolite, and transcript levels. 61
28865116 2018
15
A GATA-type transcription factor AcAREB for nitrogen metabolism is involved in regulation of cephalosporin biosynthesis in Acremonium chrysogenum. 61
28812298 2017
16
Molecular, phenotypic, and sample-associated data to describe pluripotent stem cell lines and derivatives. 61
28350385 2017
17
Transcriptome analysis of the two unrelated fungal β-lactam producers Acremonium chrysogenum and Penicillium chrysogenum: Velvet-regulated genes are major targets during conventional strain improvement programs. 61
28359302 2017
18
Penicillin production in industrial strain Penicillium chrysogenum P2niaD18 is not dependent on the copy number of biosynthesis genes. 61
28209150 2017
19
A Pediatric Cardiology Fellowship Boot Camp improves trainee confidence. 61
28148335 2016
20
Cisplatin- Versus Non-Cisplatin-based First-Line Chemotherapy for Advanced Urothelial Carcinoma Previously Treated With Perioperative Cisplatin. 61
26589729 2016
21
The siderophilic cyanobacterium Leptolyngbya sp. strain JSC-1 acclimates to iron starvation by expressing multiple isiA-family genes. 61
27071628 2016
22
Finite element modeling of light propagation in turbid media under illumination of a continuous-wave beam. 61
26835627 2016
23
PcFKH1, a novel regulatory factor from the forkhead family, controls the biosynthesis of penicillin in Penicillium chrysogenum. 61
26049046 2015
24
The autophagy-related gene Acatg1 is involved in conidiation and cephalosporin production in Acremonium chrysogenum. 61
24963594 2014
25
Direct involvement of the CreA transcription factor in penicillin biosynthesis and expression of the pcbAB gene in Penicillium chrysogenum. 61
24818689 2014
26
Strong population structure and shallow mitochondrial phylogeny in the banded guitarfish, Zapteryx exasperata (Jordan y Gilbert, 1880), from the Northern Mexican Pacific. 61
24123495 2014
27
Disruption of the nitrogen regulatory gene AcareA in Acremonium chrysogenum leads to reduction of cephalosporin production and repression of nitrogen metabolism. 61
24161729 2013
28
Role of the cmcH-ccaR intergenic region and ccaR overexpression in cephamycin C biosynthesis in Streptomyces clavuligerus. 61
23361841 2013
29
The thioredoxin reductase-encoding gene ActrxR1 is involved in the cephalosporin C production of Acremonium chrysogenum in methionine-supplemented medium. 61
22926582 2013
30
A vacuolar membrane protein affects drastically the biosynthesis of the ACV tripeptide and the beta-lactam pathway of Penicillium chrysogenum. 61
22777282 2013
31
A septation related gene AcsepH in Acremonium chrysogenum is involved in the cellular differentiation and cephalosporin production. 61
23201539 2013
32
The inducers 1,3-diaminopropane and spermidine produce a drastic increase in the expression of the penicillin biosynthetic genes for prolonged time, mediated by the laeA regulator. 61
23089625 2012
33
The regulatory factor PcRFX1 controls the expression of the three genes of β-lactam biosynthesis in Penicillium chrysogenum. 61
22960281 2012
34
Diffusion, swelling and electrical properties of polyisoprene/multiwall carbon nanotube composites in organic solvent vapours. 61
23421188 2012
35
Expression of cefF significantly decreased deacetoxycephalosporin C formation during cephalosporin C production in Acremonium chrysogenum. 61
21866341 2012
36
Penicillium chrysogenum var. halophenolicum, a new halotolerant strain with potential in the remediation of aromatic compounds in high salt environments. 61
21524896 2012
37
Characterization of an autoinducer of penicillin biosynthesis in Penicillium chrysogenum. 61
21724894 2011
38
Deep mitochondrial divergence in Baja California populations of an aquilopelagic elasmobranch: the golden cownose ray. 61
21414964 2011
39
Nonlinear biosynthetic gene cluster dose effect on penicillin production by Penicillium chrysogenum. 61
20851974 2010
40
Stimulation of cephalosporin C production in Acremonium chrysogenum M35 by glycerol. 61
20171092 2010
41
Regulation and compartmentalization of β-lactam biosynthesis. 61
21255328 2010
42
Core promoters of the penicillin biosynthesis genes and quantitative RT-PCR analysis of these genes in high and low production strain of Penicillium chrysogenum. 61
20490754 2010
43
Localization of Pcb antenna complexes in the photosynthetic prokaryote Prochlorothrix hollandica. 61
19761753 2010
44
Performance of improved bacterial cellulose application in the production of functional paper. 61
19709339 2009
45
Quantitative PCR study on the mode of action of oligosaccharide elicitors on penicillin G production by Penicillium chrysogenum. 61
19486407 2009
46
The global regulator LaeA controls penicillin biosynthesis, pigmentation and sporulation, but not roquefortine C synthesis in Penicillium chrysogenum. 61
18952140 2009
47
The transporter CefM involved in translocation of biosynthetic intermediates is essential for cephalosporin production. 61
18840096 2009
48
The heterotrimeric Galpha protein pga1 regulates biosynthesis of penicillin, chrysogenin and roquefortine in Penicillium chrysogenum. 61
18957609 2008
49
RNA-silencing in Penicillium chrysogenum and Acremonium chrysogenum: validation studies using beta-lactam genes expression. 61
18590779 2008
50
Production of functionally active Penicillium chrysogenum isopenicillin N synthase in the yeast Hansenula polymorpha. 61
18366686 2008

Variations for Prostate Cancer/brain Cancer Susceptibility

ClinVar genetic disease variations for Prostate Cancer/brain Cancer Susceptibility:

6
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 EPHB2 NM_004442.7(EPHB2):c.2167C>T (p.Gln723Ter) SNV Pathogenic 8532 rs121912582 1:23234473-23234473 1:22907980-22907980
2 EPHB2 NM_004442.7(EPHB2):c.835G>T (p.Ala279Ser) SNV Pathogenic 8533 rs35882952 1:23189553-23189553 1:22863060-22863060
3 EPHB2 NM_004442.7(EPHB2):c.*187A>T SNV risk factor 8535 rs76826147 1:23240250-23240250 1:22913757-22913757
4 EPHB2 NM_004442.7(EPHB2):c.2035G>A (p.Asp679Asn) SNV Likely benign 8534 rs28936395 1:23233346-23233346 1:22906853-22906853

Expression for Prostate Cancer/brain Cancer Susceptibility

Search GEO for disease gene expression data for Prostate Cancer/brain Cancer Susceptibility.

Pathways for Prostate Cancer/brain Cancer Susceptibility

GO Terms for Prostate Cancer/brain Cancer Susceptibility

Sources for Prostate Cancer/brain Cancer Susceptibility

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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