CAPB
MCID: PRS131
MIFTS: 15

Prostate Cancer/brain Cancer Susceptibility (CAPB)

Categories: Cancer diseases, Genetic diseases, Neuronal diseases

Aliases & Classifications for Prostate Cancer/brain Cancer Susceptibility

MalaCards integrated aliases for Prostate Cancer/brain Cancer Susceptibility:

Name: Prostate Cancer/brain Cancer Susceptibility 58 30 6 41
Prostate Cancer/brain Cancer Susceptibility, Somatic 58
Pcbc 58
Capb 58

Classifications:



External Ids:

OMIM 58 603688
MedGen 43 C1863600
SNOMED-CT via HPO 70 126951006 126980002 399068003

Summaries for Prostate Cancer/brain Cancer Susceptibility

MalaCards based summary : Prostate Cancer/brain Cancer Susceptibility, also known as prostate cancer/brain cancer susceptibility, somatic, is related to pallister-hall syndrome. An important gene associated with Prostate Cancer/brain Cancer Susceptibility is EPHB2 (EPH Receptor B2). Affiliated tissues include prostate and brain, and related phenotypes are neoplasm of the central nervous system and prostate cancer

Description from OMIM: 603688

Related Diseases for Prostate Cancer/brain Cancer Susceptibility

Diseases related to Prostate Cancer/brain Cancer Susceptibility via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 pallister-hall syndrome 10.2

Symptoms & Phenotypes for Prostate Cancer/brain Cancer Susceptibility

Human phenotypes related to Prostate Cancer/brain Cancer Susceptibility:

33
# Description HPO Frequency HPO Source Accession
1 neoplasm of the central nervous system 33 HP:0100006
2 prostate cancer 33 HP:0012125

Clinical features from OMIM:

603688

Drugs & Therapeutics for Prostate Cancer/brain Cancer Susceptibility

Search Clinical Trials , NIH Clinical Center for Prostate Cancer/brain Cancer Susceptibility

Genetic Tests for Prostate Cancer/brain Cancer Susceptibility

Genetic tests related to Prostate Cancer/brain Cancer Susceptibility:

# Genetic test Affiliating Genes
1 Prostate Cancer/brain Cancer Susceptibility 30 EPHB2

Anatomical Context for Prostate Cancer/brain Cancer Susceptibility

MalaCards organs/tissues related to Prostate Cancer/brain Cancer Susceptibility:

42
Prostate, Brain

Publications for Prostate Cancer/brain Cancer Susceptibility

Variations for Prostate Cancer/brain Cancer Susceptibility

ClinVar genetic disease variations for Prostate Cancer/brain Cancer Susceptibility:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 EPHB2 NM_004442.7(EPHB2): c.2167C> T (p.Gln723Ter) single nucleotide variant Pathogenic rs121912582 GRCh37 Chromosome 1, 23234473: 23234473
2 EPHB2 NM_004442.7(EPHB2): c.2167C> T (p.Gln723Ter) single nucleotide variant Pathogenic rs121912582 GRCh38 Chromosome 1, 22907980: 22907980
3 EPHB2 NM_004442.7(EPHB2): c.835G> T (p.Ala279Ser) single nucleotide variant Pathogenic rs35882952 GRCh37 Chromosome 1, 23189553: 23189553
4 EPHB2 NM_004442.7(EPHB2): c.835G> T (p.Ala279Ser) single nucleotide variant Pathogenic rs35882952 GRCh38 Chromosome 1, 22863060: 22863060
5 EPHB2 NM_004442.7(EPHB2): c.2035G> A (p.Asp679Asn) single nucleotide variant Pathogenic rs28936395 GRCh37 Chromosome 1, 23233346: 23233346
6 EPHB2 NM_004442.7(EPHB2): c.2035G> A (p.Asp679Asn) single nucleotide variant Pathogenic rs28936395 GRCh38 Chromosome 1, 22906853: 22906853
7 EPHB2 NM_001309193.1(EPHB2): c.3055A> T (p.Lys1019Ter) single nucleotide variant risk factor rs76826147 GRCh37 Chromosome 1, 23240250: 23240250
8 EPHB2 NM_001309193.1(EPHB2): c.3055A> T (p.Lys1019Ter) single nucleotide variant risk factor rs76826147 GRCh38 Chromosome 1, 22913757: 22913757

Expression for Prostate Cancer/brain Cancer Susceptibility

Search GEO for disease gene expression data for Prostate Cancer/brain Cancer Susceptibility.

Pathways for Prostate Cancer/brain Cancer Susceptibility

GO Terms for Prostate Cancer/brain Cancer Susceptibility

Sources for Prostate Cancer/brain Cancer Susceptibility

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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