CAPB
MCID: PRS131
MIFTS: 23

Prostate Cancer/brain Cancer Susceptibility (CAPB)

Categories: Cancer diseases, Genetic diseases, Neuronal diseases

Aliases & Classifications for Prostate Cancer/brain Cancer Susceptibility

MalaCards integrated aliases for Prostate Cancer/brain Cancer Susceptibility:

Name: Prostate Cancer/brain Cancer Susceptibility 57 29 6 39
Prostate Cancer/brain Cancer Susceptibility, Somatic 57
Pcbc 57
Capb 57

Classifications:



External Ids:

OMIM® 57 603688
MedGen 41 C1863600
SNOMED-CT via HPO 68 126951006 399068003

Summaries for Prostate Cancer/brain Cancer Susceptibility

MalaCards based summary : Prostate Cancer/brain Cancer Susceptibility, also known as prostate cancer/brain cancer susceptibility, somatic, is related to dermatitis, atopic and tularemia. An important gene associated with Prostate Cancer/brain Cancer Susceptibility is EPHB2 (EPH Receptor B2). Affiliated tissues include prostate, brain and kidney, and related phenotypes are neoplasm of the central nervous system and prostate cancer

More information from OMIM: 603688

Related Diseases for Prostate Cancer/brain Cancer Susceptibility

Diseases related to Prostate Cancer/brain Cancer Susceptibility via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 4, show less)
# Related Disease Score Top Affiliating Genes
1 dermatitis, atopic 10.1
2 tularemia 10.1
3 prostate cancer, hereditary, 1 9.9
4 brain cancer 9.9

Symptoms & Phenotypes for Prostate Cancer/brain Cancer Susceptibility

Human phenotypes related to Prostate Cancer/brain Cancer Susceptibility:

31 (showing 2, show less)
# Description HPO Frequency HPO Source Accession
1 neoplasm of the central nervous system 31 HP:0100006
2 prostate cancer 31 HP:0012125

Clinical features from OMIM®:

603688 (Updated 05-Apr-2021)

Drugs & Therapeutics for Prostate Cancer/brain Cancer Susceptibility

Search Clinical Trials , NIH Clinical Center for Prostate Cancer/brain Cancer Susceptibility

Genetic Tests for Prostate Cancer/brain Cancer Susceptibility

Genetic tests related to Prostate Cancer/brain Cancer Susceptibility:

# Genetic test Affiliating Genes
1 Prostate Cancer/brain Cancer Susceptibility 29 EPHB2

Anatomical Context for Prostate Cancer/brain Cancer Susceptibility

MalaCards organs/tissues related to Prostate Cancer/brain Cancer Susceptibility:

40
Prostate, Brain, Kidney

Publications for Prostate Cancer/brain Cancer Susceptibility

Articles related to Prostate Cancer/brain Cancer Susceptibility:

(showing 188, show less)
# Title Authors PMID Year
1
A common nonsense mutation in EphB2 is associated with prostate cancer risk in African American men with a positive family history. 57 6
16155194 2006
2
Nonsense-mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancer. 6 57
15300251 2004
3
PCAP is the major known prostate cancer predisposing locus in families from south and west Europe. 57
11313747 2001
4
Suggestive evidence for a site specific prostate cancer gene on chromosome 1p36. The CRC/BPG UK Familial Prostate Cancer Study Coordinators and Collaborators. The EU Biomed Collaborators. 57
11186936 2000
5
Evidence for a rare prostate cancer-susceptibility locus at chromosome 1p36. 57
10053012 1999
6
Covered vs bare stent for distal malignant biliary obstruction due to primary common biliary cancer. 61
33545967 2021
7
Measurement Invariance of the Persistent Complex Bereavement Disorder Checklist With Respect to Youth Gender, Race, Ethnicity, and Age. 61
32686226 2020
8
Comparative genomics of Alexander Fleming's original Penicillium isolate (IMI 15378) reveals sequence divergence of penicillin synthesis genes. 61
32973216 2020
9
Non-viral vector based gene transfection with human induced pluripotent stem cells derived cardiomyocytes. 61
31591436 2019
10
Screening and treatment to reduce severe hyperbilirubinaemia in infants in primary care (STARSHIP): a factorial stepped-wedge cluster randomised controlled trial protocol. 61
31005942 2019
11
Characterizing the Health-Related Quality of Life Burden of Overactive Bladder Using Disease-Specific Patient-Reported Outcome Measures: A Systematic Literature Review. 61
30715686 2019
12
Enhancing the production of cephalosporin C through modulating the autophagic process of Acremonium chrysogenum. 61
30424777 2018
13
A Myb transcription factor represses conidiation and cephalosporin C production in Acremonium chrysogenum. 61
29870835 2018
14
Power input effects on degeneration in prolonged penicillin chemostat cultures: A systems analysis at flux, residual glucose, metabolite, and transcript levels. 61
28865116 2018
15
A GATA-type transcription factor AcAREB for nitrogen metabolism is involved in regulation of cephalosporin biosynthesis in Acremonium chrysogenum. 61
28812298 2017
16
Molecular, phenotypic, and sample-associated data to describe pluripotent stem cell lines and derivatives. 61
28350385 2017
17
Transcriptome analysis of the two unrelated fungal β-lactam producers Acremonium chrysogenum and Penicillium chrysogenum: Velvet-regulated genes are major targets during conventional strain improvement programs. 61
28359302 2017
18
Penicillin production in industrial strain Penicillium chrysogenum P2niaD18 is not dependent on the copy number of biosynthesis genes. 61
28209150 2017
19
A Pediatric Cardiology Fellowship Boot Camp improves trainee confidence. 61
28148335 2016
20
Cisplatin- Versus Non-Cisplatin-based First-Line Chemotherapy for Advanced Urothelial Carcinoma Previously Treated With Perioperative Cisplatin. 61
26589729 2016
21
The siderophilic cyanobacterium Leptolyngbya sp. strain JSC-1 acclimates to iron starvation by expressing multiple isiA-family genes. 61
27071628 2016
22
Finite element modeling of light propagation in turbid media under illumination of a continuous-wave beam. 61
26835627 2016
23
PcFKH1, a novel regulatory factor from the forkhead family, controls the biosynthesis of penicillin in Penicillium chrysogenum. 61
26049046 2015
24
The autophagy-related gene Acatg1 is involved in conidiation and cephalosporin production in Acremonium chrysogenum. 61
24963594 2014
25
Direct involvement of the CreA transcription factor in penicillin biosynthesis and expression of the pcbAB gene in Penicillium chrysogenum. 61
24818689 2014
26
Strong population structure and shallow mitochondrial phylogeny in the banded guitarfish, Zapteryx exasperata (Jordan y Gilbert, 1880), from the Northern Mexican Pacific. 61
24123495 2014
27
Disruption of the nitrogen regulatory gene AcareA in Acremonium chrysogenum leads to reduction of cephalosporin production and repression of nitrogen metabolism. 61
24161729 2013
28
Role of the cmcH-ccaR intergenic region and ccaR overexpression in cephamycin C biosynthesis in Streptomyces clavuligerus. 61
23361841 2013
29
The thioredoxin reductase-encoding gene ActrxR1 is involved in the cephalosporin C production of Acremonium chrysogenum in methionine-supplemented medium. 61
22926582 2013
30
A septation related gene AcsepH in Acremonium chrysogenum is involved in the cellular differentiation and cephalosporin production. 61
23201539 2013
31
A vacuolar membrane protein affects drastically the biosynthesis of the ACV tripeptide and the beta-lactam pathway of Penicillium chrysogenum. 61
22777282 2013
32
The inducers 1,3-diaminopropane and spermidine produce a drastic increase in the expression of the penicillin biosynthetic genes for prolonged time, mediated by the laeA regulator. 61
23089625 2012
33
The regulatory factor PcRFX1 controls the expression of the three genes of β-lactam biosynthesis in Penicillium chrysogenum. 61
22960281 2012
34
Diffusion, swelling and electrical properties of polyisoprene/multiwall carbon nanotube composites in organic solvent vapours. 61
23421188 2012
35
Expression of cefF significantly decreased deacetoxycephalosporin C formation during cephalosporin C production in Acremonium chrysogenum. 61
21866341 2012
36
Penicillium chrysogenum var. halophenolicum, a new halotolerant strain with potential in the remediation of aromatic compounds in high salt environments. 61
21524896 2012
37
Characterization of an autoinducer of penicillin biosynthesis in Penicillium chrysogenum. 61
21724894 2011
38
Deep mitochondrial divergence in Baja California populations of an aquilopelagic elasmobranch: the golden cownose ray. 61
21414964 2011
39
Nonlinear biosynthetic gene cluster dose effect on penicillin production by Penicillium chrysogenum. 61
20851974 2010
40
Stimulation of cephalosporin C production in Acremonium chrysogenum M35 by glycerol. 61
20171092 2010
41
Regulation and compartmentalization of β-lactam biosynthesis. 61
21255328 2010
42
Core promoters of the penicillin biosynthesis genes and quantitative RT-PCR analysis of these genes in high and low production strain of Penicillium chrysogenum. 61
20490754 2010
43
Localization of Pcb antenna complexes in the photosynthetic prokaryote Prochlorothrix hollandica. 61
19761753 2010
44
Performance of improved bacterial cellulose application in the production of functional paper. 61
19709339 2009
45
Quantitative PCR study on the mode of action of oligosaccharide elicitors on penicillin G production by Penicillium chrysogenum. 61
19486407 2009
46
The global regulator LaeA controls penicillin biosynthesis, pigmentation and sporulation, but not roquefortine C synthesis in Penicillium chrysogenum. 61
18952140 2009
47
The transporter CefM involved in translocation of biosynthetic intermediates is essential for cephalosporin production. 61
18840096 2009
48
The heterotrimeric Galpha protein pga1 regulates biosynthesis of penicillin, chrysogenin and roquefortine in Penicillium chrysogenum. 61
18957609 2008
49
RNA-silencing in Penicillium chrysogenum and Acremonium chrysogenum: validation studies using beta-lactam genes expression. 61
18590779 2008
50
Production of functionally active Penicillium chrysogenum isopenicillin N synthase in the yeast Hansenula polymorpha. 61
18366686 2008
51
Binding of the PTA1 transcriptional activator to the divergent promoter region of the first two genes of the penicillin pathway in different Penicillium species. 61
17924108 2007
52
Functional characterization of the penicillin biosynthetic gene cluster of Penicillium chrysogenum Wisconsin54-1255. 61
17548217 2007
53
Identification of the special pair of photosystem II in a chlorophyll d-dominated cyanobacterium. 61
17431035 2007
54
An efficient fungal RNA-silencing system using the DsRed reporter gene. 61
17142377 2007
55
Synthesis of extended polyphosphacumulenes. 61
17009365 2006
56
Transcriptional and bioinformatic analysis of the 56.8 kb DNA region amplified in tandem repeats containing the penicillin gene cluster in Penicillium chrysogenum. 61
16713314 2006
57
Genome-wide analysis of differentially expressed genes from Penicillium chrysogenum grown with a repressing or a non-repressing carbon source. 61
16362424 2006
58
Iron deficiency induces a chlorophyll d-binding Pcb antenna system around Photosystem I in Acaryochloris marina. 61
15975547 2005
59
CPCR1, but not its interacting transcription factor AcFKH1, controls fungal arthrospore formation in Acremonium chrysogenum. 61
15882416 2005
60
Phylogenetic analyses of the core antenna domain: investigating the origin of photosystem I. 61
15785845 2005
61
AcFKH1, a novel member of the forkhead family, associates with the RFX transcription factor CPCR1 in the cephalosporin C-producing fungus Acremonium chrysogenum. 61
15527986 2004
62
Construction of transformant reporters carrying fused genes using pcbC promoter of Pseudomonas sp DJ-12 for detection of aromatic pollutants. 61
15038547 2004
63
Winged helix transcription factor CPCR1 is involved in regulation of beta-lactam biosynthesis in the fungus Acremonium chrysogenum. 61
14871943 2004
64
Regulation of penicillin biosynthesis in filamentous fungi. 61
15719552 2004
65
Detection of Prochlorothrix in brackish waters by specific amplification of pcb genes. 61
14532086 2003
66
Cloning and expression analysis of the pcbAB-pcbC beta-lactam genes in the marine fungus Kallichroma tethys. 61
12571064 2003
67
A novel epimerization system in fungal secondary metabolism involved in the conversion of isopenicillin N into penicillin N in Acremonium chrysogenum. 61
12228250 2002
68
The effects of haloalkene cysteine conjugates on cytosolic free calcium levels in LLC-PK(1) cells--studies utilising digital imaging fluorescence microscopy. 61
12049843 2002
69
Production of penicillin by fungi growing on food products: identification of a complete penicillin gene cluster in Penicillium griseofulvum and a truncated cluster in Penicillium verrucosum. 61
11872470 2002
70
Biosynthetic pathway of cephabacins in Lysobacter lactamgenus: molecular and biochemical characterization of the upstream region of the gene clusters for engineering of novel antibiotics. 61
11676571 2001
71
Expression and phylogeny of the multiple antenna genes of the low-light-adapted strain Prochlorococcus marinus SS120 (Oxyphotobacteria). 61
11575723 2001
72
Functional analysis of promoter sequences of cephalosporin C biosynthesis genes from Acremonium chrysogenum: specific DNA-protein interactions and characterization of the transcription factor PACC. 61
11405634 2001
73
The iron-regulated isiA gene of Fischerella muscicola strain PCC 73103 is linked to a likewise regulated gene encoding a Pcb-like chlorophyll-binding protein. 61
11287157 2001
74
Targeted inactivation of the mecB gene, encoding cystathionine-gamma-lyase, shows that the reverse transsulfuration pathway is required for high-level cephalosporin biosynthesis in Acremonium chrysogenum C10 but not for methionine induction of the cephalosporin genes. 61
11160109 2001
75
Quantitative analysis of Penicillium chrysogenum Wis54-1255 transformants overexpressing the penicillin biosynthetic genes. 61
11180058 2001
76
The gene encoding gamma-actin from the cephalosporin producer Acremonium chrysogenum. 61
11152070 2000
77
xylP promoter-based expression system and its use for antisense downregulation of the Penicillium chrysogenum nitrogen regulator NRE. 61
11055928 2000
78
Loss of glucose repression in an Acremonium chrysogenum beta-lactam producer strain and its restoration by multiple copies of the cre1 gene. 61
11092632 2000
79
Overexpression of the lys1 gene in Penicillium chrysogenum: homocitrate synthase levels, alpha-aminoadipic acid pool and penicillin production. 61
10952007 2000
80
Filtered platelet concentrates from pooled buffy coats show comparable storage lesions when stored for 9 d at 20-24 degrees C or when supplemented with thromboSol at 2-6 degrees C. 61
10901594 2000
81
Characterization of the pcbE gene encoding 2-hydroxypenta-2,4-dienoate hydratase in Pseudomonas sp. DJ-12. 61
10836749 2000
82
The fungal CPCR1 protein, which binds specifically to beta-lactam biosynthesis genes, is related to human regulatory factor X transcription factors. 61
10734077 2000
83
A novel heptameric sequence (TTAGTAA) is the binding site for a protein required for high level expression of pcbAB, the first gene of the penicillin biosynthesis in Penicillium chrysogenum. 61
10644695 2000
84
Early cephamycin biosynthetic genes are expressed from a polycistronic transcript in Streptomyces clavuligerus. 61
10629179 2000
85
Organization of the gene cluster for biosynthesis of penicillin in Penicillium nalgiovense and antibiotic production in cured dry sausages. 61
10049889 1999
86
Transcription of the pcbAB, pcbC and penDE genes of Penicillium chrysogenum AS-P-78 is repressed by glucose and the repression is not reversed by alkaline pHs. 61
10075414 1999
87
Penicillin and cephalosporin biosynthesis: mechanism of carbon catabolite regulation of penicillin production. 61
10422579 1999
88
Transcriptional control of expression of fungal beta-lactam biosynthesis genes. 61
10422583 1999
89
Gene organization and plasticity of the beta-lactam genes in different filamentous fungi. 61
10422582 1999
90
Transcript analysis of the pcbABC genes encoding the antenna apoproteins in the photosynthetic prokaryote, Prochlorothrix hollandica. 61
9835028 1998
91
The nine genes of the Nocardia lactamdurans cephamycin cluster are transcribed into large mRNAs from three promoters, two of them located in a bidirectional promoter region. 61
9765587 1998
92
Molecular regulation of beta-lactam biosynthesis in filamentous fungi. 61
9729600 1998
93
New aspects of genes and enzymes for beta-lactam antibiotic biosynthesis. 61
9720195 1998
94
The 38 kDa chlorophyll a/b protein of the prokaryote Prochlorothrix hollandica is encoded by a divergent pcb gene. 61
9526503 1998
95
Regulation of the Aspergillus nidulans penicillin biosynthesis gene acvA (pcbAB) by amino acids: implication for involvement of transcription factor PACC. 61
9501424 1998
96
Secondary pleural involvement by an AIDS-related anaplastic large cell (CD30+) lymphoma simulating metastatic adenocarcinoma. 61
9484639 1998
97
Expression of the cefG gene is limiting for cephalosporin biosynthesis in Acremonium chrysogenum. 61
9421924 1997
98
Efficient synthesis of the blood-coagulation inhibitor hirudin in the filamentous fungus Acremonium chrysogenum. 61
9274048 1997
99
Molecular regulation of penicillin biosynthesis in Aspergillus (Emericella) nidulans. 61
9066103 1997
100
Biotransformation, excretion and nephrotoxicity of haloalkene-derived cysteine S-conjugates. 61
9458184 1997
101
Factors affecting DNA-binding proteins and pcbC transcript levels in Penicillium chrysogenum. 61
8929398 1996
102
Structure of the pcbC gene encoding 2,3-dihydroxybiphenyl dioxygenase of Pseudomonas sp. P20. 61
8806585 1996
103
Genetic and biochemical analysis of the cysteinyl residues of isopenicillin N synthase from Streptomyces clavuligerus. 61
8776857 1996
104
Identification of a major cis-acting DNA element controlling the bidirectionally transcribed penicillin biosynthesis genes acvA (pcbAB) and ipnA (pcbC) of Aspergillus nidulans. 61
8682797 1996
105
Assessment of the role of glutathione conjugation in the protection afforded by anethol dithiolthione against hexachloro-1,3-butadiene-induced nephrotoxicity. 61
8685901 1996
106
Induction of a permeability transition in rat kidney mitochondria by pentachlorobutadienyl cysteine: a beta-lyase-independent process. 61
8660702 1996
107
The Aspergillus nidulans penicillin-biosynthesis gene aat (penDE) is controlled by a CCAAT-containing DNA element. 61
8706667 1996
108
Characterization of a Penicillium chrysogenum gene encoding a PacC transcription factor and its binding sites in the divergent pcbAB-pcbC promoter of the penicillin biosynthetic cluster. 61
8736532 1996
109
Organization and expression in Pseudomonas putida of the gene cluster involved in cephalosporin biosynthesis from Lysobacter lactamgenus YK90. 61
8737573 1996
110
Genetic structures of the genes encoding 2,3-dihydroxybiphenyl 1,2-dioxygenase and 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid hydrolase from biphenyl- and 4-chlorobiphenyl-degrading Pseudomonas sp. strain DJ-12. 61
8572703 1996
111
Molecular analysis of the gene cluster involved in cephalosporin biosynthesis from Lysobacter lactamgenus YK90. 61
8703429 1996
112
Mutants blocked in penicillin biosynthesis show a deletion of the entire penicillin gene cluster at a specific site within a conserved hexanucleotide sequence. 61
8703430 1996
113
Characterization of the cefF gene of Nocardia lactamdurans encoding a 3'-methylcephem hydroxylase different from the 7-cephem hydroxylase. 61
8703431 1996
114
Transformation of Sordaria macrospora to hygromycin B resistance: characterization of transformants by electrophoretic karyotyping and tetrad analysis. 61
8595663 1995
115
The sulfoxidation of the hexachlorobutadiene metabolite N-acetyl-S-(1,2,3,4,4-pentachlorobutadienyl)-L-cysteine is catalyzed by human cytochrome P450 3A enzymes. 61
8555406 1995
116
The role of cytochrome P4503A1/2 in the sex-specific sulfoxidation of the hexachlorobutadiene metabolite, N-acetyl-S-(pentachlorobutadienyl)-L-cysteine in rats. 61
7493554 1995
117
NRE, the major nitrogen regulatory protein of Penicillium chrysogenum, binds specifically to elements in the intergenic promoter regions of nitrate assimilation and penicillin biosynthetic gene clusters. 61
8590470 1995
118
The penicillin gene cluster is amplified in tandem repeats linked by conserved hexanucleotide sequences. 61
7597101 1995
119
Sex differences in hexachlorobutadiene biotransformation and nephrotoxicity. 61
7785049 1995
120
Use of reporter genes to identify recessive trans-acting mutations specifically involved in the regulation of Aspergillus nidulans penicillin biosynthesis genes. 61
7677843 1995
121
Nuclear DNA-binding proteins which recognize the intergenic control region of penicillin biosynthetic genes. 61
7614558 1995
122
Genes for beta-lactam antibiotic biosynthesis. 61
7771766 1995
123
Possible involvement of the lysine epsilon-aminotransferase gene (lat) in the expression of the genes encoding ACV synthetase (pcbAB) and isopenicillin N synthase (pcbC) in Streptomyces clavuligerus. 61
7881554 1994
124
A reporter gene analysis of penicillin biosynthesis gene expression in Penicillium chrysogenum and its regulation by nitrogen and glucose catabolite repression. 61
7811083 1994
125
Expression studies with the bidirectional pcbAB-pcbC promoter region from Acremonium chrysogenum using reporter gene fusions. 61
7765820 1994
126
Antagonistic activity of the food-related filamentous fungus Penicillium nalgiovense by the production of penicillin. 61
7944371 1994
127
Cloning, sequencing and disruption of a gene from Streptomyces clavuligerus involved in clavulanic acid biosynthesis. 61
8088547 1994
128
Molecular characterization of three loss-of-function mutations in the isopenicillin N-acyltransferase gene (penDE) of Penicillium chrysogenum. 61
7519594 1994
129
Improved expression of a hybrid Streptomyces clavuligerus cefE gene in Penicillium chrysogenum. 61
8010669 1994
130
Transcriptional mapping of the genes encoding the early enzymes of the cephamycin biosynthetic pathway of Streptomyces clavuligerus. 61
8181755 1994
131
Interdependence of gene expression for early steps of cephalosporin synthesis in Streptomyces clavuligerus. 61
8010661 1994
132
Strychnine and glycine protect renal proximal tubules from various nephrotoxicants and act in the late phase of necrotic cell injury. 61
8171427 1994
133
Security for decentralized health information systems. 61
8188407 1994
134
Exogenous methionine increases levels of mRNAs transcribed from pcbAB, pcbC, and cefEF genes, encoding enzymes of the cephalosporin biosynthetic pathway, in Acremonium chrysogenum. 61
8106341 1994
135
Expression of genes and processing of enzymes for the biosynthesis of penicillins and cephalosporins. 61
7847890 1994
136
Targeted integration into the Acremonium chrysogenum genome: disruption of the pcbC gene. 61
8299158 1993
137
Biochemical characterization and molecular genetics of nine mutants of Penicillium chrysogenum impaired in penicillin biosynthesis. 61
8416976 1993
138
Physiological studies related to the immobilization of Penicillium chrysogenum and penicillin production. 61
7763358 1993
139
High-level expression of the Streptomyces clavuligerus isopenicillin N synthase gene in Escherichia coli. 61
1476443 1992
140
Resolution of chromosomes III and VI of Aspergillus nidulans by pulsed-field gel electrophoresis shows that the penicillin biosynthetic pathway genes pcbAB, pcbC, and penDE are clustered on chromosome VI (3.0 megabases). 61
1400258 1992
141
Mitotic instability of integrated plasmids in Penicillium chrysogenum transformants. 61
1368897 1992
142
Isolation of deacetoxycephalosporin C from fermentation broths of Penicillium chrysogenum transformants: construction of a new fungal biosynthetic pathway. 61
1354366 1992
143
The cefG gene of Cephalosporium acremonium is linked to the cefEF gene and encodes a deacetylcephalosporin C acetyltransferase closely related to homoserine O-acetyltransferase. 61
1569032 1992
144
Analysis of promoter activity by transformation of Acremonium chrysogenum. 61
1318244 1992
145
Clusters of genes for the biosynthesis of antibiotics: regulatory genes and overproduction of pharmaceuticals. 61
1368054 1992
146
Transcriptional analysis of the isopenicillin N synthase-encoding gene of Streptomyces clavuligerus. 61
1547956 1992
147
Transcript analysis of penicillin genes from Penicillium chrysogenum. 61
1735125 1992
148
A gene encoding lysine 6-aminotransferase, which forms the beta-lactam precursor alpha-aminoadipic acid, is located in the cluster of cephamycin biosynthetic genes in Nocardia lactamdurans. 61
1917857 1991
149
Localization of the lysine epsilon-aminotransferase (lat) and delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase (pcbAB) genes from Streptomyces clavuligerus and production of lysine epsilon-aminotransferase activity in Escherichia coli. 61
1917855 1991
150
Genes directly involved in the biosynthesis of beta-lactam antibiotics. 61
1867773 1991
151
Intestinal absorption of S-(pentachlorobutadienyl)glutathione and S-(pentachlorobutadienyl)-L-cysteine, the glutathione and cysteine S-conjugates of hexachlorobuta-1,3-diene. 61
1680640 1991
152
The cephamycin biosynthetic genes pcbAB, encoding a large multidomain peptide synthetase, and pcbC of Nocardia lactamdurans are clustered together in an organization different from the same genes in Acremonium chrysogenum and Penicillium chrysogenum. 61
1956290 1991
153
Characterization of the Cephalosporium acremonium pcbAB gene encoding alpha-aminoadipyl-cysteinyl-valine synthetase, a large multidomain peptide synthetase: linkage to the pcbC gene as a cluster of early cephalosporin biosynthetic genes and evidence of multiple functional domains. 61
1706706 1991
154
Chromosome rearrangements in improved cephalosporin C-producing strains of Acremonium chrysogenum. 61
1868572 1991
155
Cloning and location of a gene governing lysine epsilon-aminotransferase, an enzyme initiating beta-lactam biosynthesis in Streptomyces spp. 61
1991735 1991
156
Pentachlorobutadienyl-L-cysteine (PCBC) toxicity: the importance of mitochondrial dysfunction. 61
1774769 1991
157
Role of lipid peroxidation in renal proximal tubule cell death induced by haloalkene cysteine conjugates. 61
1987660 1991
158
Strain improvement of Penicillium chrysogenum by recombinant DNA techniques. 61
1367496 1991
159
Cloning and characterization of the isopenicillin N synthase gene of Streptomyces griseus NRRL 3851 and studies of expression and complementation of the cephamycin pathway in Streptomyces clavuligerus. 61
1901702 1991
160
Molecular characterization and functional analysis in Aspergillus nidulans of the 5'-region of the Penicillium chrysogenum isopenicillin N synthetase gene. 61
1367495 1991
161
Expression of the penDE gene of Penicillium chrysogenum encoding isopenicillin N acyltransferase in Cephalosporium acremonium: production of benzylpenicillin by the transformants. 61
1900348 1991
162
Gene disruption of the pcbAB gene encoding ACV synthetase in Cephalosporium acremonium. 61
2076552 1990
163
Molecular characterization of the acyl-coenzyme A:isopenicillin N acyltransferase gene (penDE) from Penicillium chrysogenum and Aspergillus nidulans and activity of recombinant enzyme in Escherichia coli. 61
2120195 1990
164
The multifunctional peptide synthetase performing the first step of penicillin biosynthesis in Penicillium chrysogenum is a 421,073 dalton protein similar to Bacillus brevis peptide antibiotic synthetases. 61
2118102 1990
165
The cluster of penicillin biosynthetic genes. Identification and characterization of the pcbAB gene encoding the alpha-aminoadipyl-cysteinyl-valine synthetase and linkage to the pcbC and penDE genes. 61
2129535 1990
166
The effect of haloalkene cysteine conjugates on rat renal glutathione reductase and lipoyl dehydrogenase activities. 61
2360207 1990
167
Cloning, characterization of the acyl-CoA:6-amino penicillanic acid acyltransferase gene of Aspergillus nidulans and linkage to the isopenicillin N synthase gene. 61
2166227 1990
168
Cloning and expression of a hybrid Streptomyces clavuligerus cefE gene in Penicillium chrysogenum. 61
2111228 1990
169
Regulation of isopenicillin N synthetase (IPNS) gene expression in Acremonium chrysogenum. 61
1366405 1990
170
Cysteine conjugate toxicity, metabolism, and binding to macromolecules in isolated rat kidney mitochondria. 61
2314393 1990
171
Nucleotide sequence of the isopenicillin N synthase gene (pcbC) of the gram negative Flavobacterium sp. SC 12,154. 61
2308852 1990
172
The effects of haloalkene cysteine conjugates on cytosolic free calcium levels in suspensions of rat renal proximal tubules. 61
2283670 1990
173
Large amplification of a 35-kb DNA fragment carrying two penicillin biosynthetic genes in high penicillin producing strains of Penicillium chrysogenum. 61
2515004 1989
174
Characterization of a loss-of-function mutation in the isopenicillin N synthetase gene of Acremonium chrysogenum. 61
2620834 1989
175
Pentachlorobutadienyl-L-cysteine uncouples oxidative phosphorylation by dissipating the proton gradient. 61
2551076 1989
176
Two genes involved in penicillin biosynthesis are linked in a 5.1 kb SalI fragment in the genome of Penicillium chrysogenum. 61
2511425 1989
177
An electrophoretic molecular karyotype for an industrial strain of Cephalosporium acremonium. 61
2673927 1989
178
Assessment of unscheduled DNA synthesis in a cultured line of renal epithelial cells exposed to cysteine S-conjugates of haloalkenes and haloalkanes. 61
2704384 1989
179
Inhibition of rat kidney mitochondrial DNA, RNA and protein synthesis by halogenated cysteine S-conjugates. 61
2467759 1989
180
Metabolism and excretion of S-conjugates derived from hexachlorobutadiene in the isolated perfused rat kidney. 61
3419428 1988
181
Thioacylating agents as ultimate intermediates in the beta-lyase catalysed metabolism of S-(pentachloro-butadienyl)-L-cysteine. 61
3168080 1988
182
DNA-binding of sulfur-containing metabolites from 35S-(pentachlorobutadienyl)-L-cysteine in bacteria and isolated renal tubular cells. 61
3078293 1988
183
Role of metabolic activation in the toxicity of S-(pentachlorobutadienyl)glutathione and S- (pentachlorobutadienyl)- l -cysteine in the isolated perfused rat kidney. 61
20837438 1988
184
Toxicity of S-pentachlorobutadienyl-L-cysteine studied with isolated rat renal cortical mitochondria. 61
3674880 1987
185
Enzymatic transformation of mercapturic acids derived from halogenated alkenes to reactive and mutagenic intermediates. 61
3307787 1987
186
A mechanism of S-(1,2,3,4,4-pentachloro-1,3-butadienyl)-L-cysteine toxicity to rabbit renal proximal tubules. 61
3660416 1987
187
Bacterial beta-lyase mediated cleavage and mutagenicity of cysteine conjugates derived from the nephrocarcinogenic alkenes trichloroethylene, tetrachloroethylene and hexachlorobutadiene. 61
3536138 1986
188
In vivo and in vitro nephrotoxicity of the cysteine conjugate of hexachlorobutadiene. 61
6620416 1983

Variations for Prostate Cancer/brain Cancer Susceptibility

ClinVar genetic disease variations for Prostate Cancer/brain Cancer Susceptibility:

6 (showing 4, show less)
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 EPHB2 NM_004442.7(EPHB2):c.2167C>T (p.Gln723Ter) SNV Pathogenic 8532 rs121912582 GRCh37: 1:23234473-23234473
GRCh38: 1:22907980-22907980
2 EPHB2 NM_004442.7(EPHB2):c.835G>T (p.Ala279Ser) SNV Pathogenic 8533 rs35882952 GRCh37: 1:23189553-23189553
GRCh38: 1:22863060-22863060
3 EPHB2 NM_004442.7(EPHB2):c.*187A>T SNV risk factor 8535 rs76826147 GRCh37: 1:23240250-23240250
GRCh38: 1:22913757-22913757
4 EPHB2 NM_004442.7(EPHB2):c.2035G>A (p.Asp679Asn) SNV Likely benign 8534 rs28936395 GRCh37: 1:23233346-23233346
GRCh38: 1:22906853-22906853

Expression for Prostate Cancer/brain Cancer Susceptibility

Search GEO for disease gene expression data for Prostate Cancer/brain Cancer Susceptibility.

Pathways for Prostate Cancer/brain Cancer Susceptibility

GO Terms for Prostate Cancer/brain Cancer Susceptibility

Sources for Prostate Cancer/brain Cancer Susceptibility

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
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49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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