HPC11
MCID: PRS117
MIFTS: 24

Prostate Cancer, Hereditary, 11 (HPC11)

Categories: Cancer diseases, Genetic diseases, Rare diseases, Reproductive diseases
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Aliases & Classifications for Prostate Cancer, Hereditary, 11

MalaCards integrated aliases for Prostate Cancer, Hereditary, 11:

Name: Prostate Cancer, Hereditary, 11 57 73 12 71
Hpc11 57 73
Familial Prostate Cancer 11 73

Classifications:



External Ids:

OMIM® 57 611955
MeSH 43 D011471
MedGen 40 C2677773
UMLS 71 C2677773

Summaries for Prostate Cancer, Hereditary, 11

UniProtKB/Swiss-Prot: 73 A condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.

MalaCards based summary: Prostate Cancer, Hereditary, 11, is also known as hpc11. An important gene associated with Prostate Cancer, Hereditary, 11 is HNF1B (HNF1 Homeobox B). Affiliated tissues include prostate.

More information from OMIM: 611955

Related Diseases for Prostate Cancer, Hereditary, 11

Symptoms & Phenotypes for Prostate Cancer, Hereditary, 11

Clinical features from OMIM®:

611955 (Updated 08-Dec-2022)

Drugs & Therapeutics for Prostate Cancer, Hereditary, 11

Search Clinical Trials, NIH Clinical Center for Prostate Cancer, Hereditary, 11

Genetic Tests for Prostate Cancer, Hereditary, 11

Anatomical Context for Prostate Cancer, Hereditary, 11

Organs/tissues related to Prostate Cancer, Hereditary, 11:

MalaCards : Prostate

Publications for Prostate Cancer, Hereditary, 11

Articles related to Prostate Cancer, Hereditary, 11:

# Title Authors PMID Year
1
Large-scale fine mapping of the HNF1B locus and prostate cancer risk. 57
21576123 2011
2
Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12. 57
18758462 2008
3
Chromosome 17q12 variants contribute to risk of early-onset prostate cancer. 57
18701471 2008
4
Multiple newly identified loci associated with prostate cancer susceptibility. 57
18264097 2008
5
Multiple loci identified in a genome-wide association study of prostate cancer. 57
18264096 2008
6
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. 57
17603485 2007
7
African-American heredity prostate cancer study: a model for genetic research. 62
11798061 2001

Variations for Prostate Cancer, Hereditary, 11

Cosmic variations for Prostate Cancer, Hereditary, 11:

8 (show top 50) (show all 7592)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM87273255 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.8849G>A p.R2950H 16:72793833-72793833 4
2 COSM87278310 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.5650G>T p.E1884* 16:72797032-72797032 4
3 COSM102023521 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.598C>T p.R200* 16:72889839-72889839 4
4 COSM102020948 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.791C>A p.S264* 16:72812035-72812035 4
5 COSM102027229 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.2908G>T p.E970* 16:72797032-72797032 4
6 COSM149310968 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.5893C>T p.Q1965* 16:72796789-72796789 4
7 COSM87289963 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.2728G>A p.E910K 16:72950957-72950957 4
8 COSM87277276 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.2986A>T p.K996* 16:72950699-72950699 4
9 COSM102022171 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.6107G>A p.R2036H 16:72793833-72793833 4
10 COSM102025889 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.244A>T p.K82* 16:72950699-72950699 4
11 COSM149331699 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.5114C>G p.S1705* 16:72797568-72797568 4
12 COSM87287233 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.4819C>T p.Q1607* 16:72797863-72797863 4
13 COSM87296500 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.5114C>G p.S1705* 16:72797568-72797568 4
14 COSM149269669 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.3340C>T p.R1114* 16:72889839-72889839 4
15 COSM87271970 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.3533C>A p.S1178* 16:72812035-72812035 4
16 COSM149281678 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.5650G>T p.E1884* 16:72797032-72797032 4
17 COSM149265910 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.8849G>A p.R2950H 16:72793833-72793833 4
18 COSM87274612 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.3340C>T p.R1114* 16:72889839-72889839 4
19 COSM102031608 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.-23-8776C>G p.? 16:72959741-72959741 4
20 COSM149307401 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.4819C>T p.Q1607* 16:72797863-72797863 4
21 COSM87288892 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.5893C>T p.Q1965* 16:72796789-72796789 4
22 COSM149287761 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.6445C>T p.R2149C 16:72796237-72796237 4
23 COSM102037736 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.2077C>T p.Q693* 16:72797863-72797863 4
24 COSM149262752 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.3533C>A p.S1178* 16:72812035-72812035 4
25 COSM87281944 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.405C>G p.Y135* 16:72959741-72959741 4
26 COSM102047721 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.2372C>G p.S791* 16:72797568-72797568 4
27 COSM102029776 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.3703C>T p.R1235C 16:72796237-72796237 4
28 COSM87280241 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.6445C>T p.R2149C 16:72796237-72796237 4
29 COSM149314230 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.2728G>A p.E910K 16:72950957-72950957 4
30 COSM149278210 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.2986A>T p.K996* 16:72950699-72950699 4
31 COSM102039151 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.3151C>T p.Q1051* 16:72796789-72796789 4
32 COSM102040223 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.-15G>A p.? 16:72950957-72950957 4
33 COSM149292073 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.405C>G p.Y135* 16:72959741-72959741 4
34 COSM89894202 YES1 prostate,NS,carcinoma,adenocarcinoma c.119C>G p.S40* 18:756709-756709 4
35 COSM136834926 YES1 prostate,NS,carcinoma,adenocarcinoma c.590-1G>T p.? 18:745858-745858 4
36 COSM152021810 YES1 prostate,NS,carcinoma,adenocarcinoma c.575-1G>T p.? 18:745858-745858 4
37 COSM152022004 YES1 prostate,NS,carcinoma,adenocarcinoma c.119C>G p.S40* 18:756709-756709 4
38 COSM136836036 YES1 prostate,NS,carcinoma,adenocarcinoma c.134C>G p.S45* 18:756709-756709 4
39 COSM89892790 YES1 prostate,NS,carcinoma,adenocarcinoma c.575-1G>T p.? 18:745858-745858 4
40 COSM104882949 XPO1 prostate,NS,carcinoma,adenocarcinoma c.1259T>C p.M420T 2:61493040-61493040 4
41 COSM104239299 XPO1 prostate,NS,carcinoma,adenocarcinoma c.1384G>T p.V462F 2:61492915-61492915 4
42 COSM101975701 XPO1 prostate,NS,carcinoma,adenocarcinoma c.1711G>A p.E571K 2:61492337-61492337 4
43 COSM101977073 XPO1 prostate,NS,carcinoma,adenocarcinoma c.1259T>C p.M420T 2:61493040-61493040 4
44 COSM101976154 XPO1 prostate,NS,carcinoma,adenocarcinoma c.2468T>G p.F823C 2:61485808-61485808 4
45 COSM104881227 XPO1 prostate,NS,carcinoma,adenocarcinoma c.1711G>A p.E571K 2:61492337-61492337 4
46 COSM104238027 XPO1 prostate,NS,carcinoma,adenocarcinoma c.3101T>G p.F1034C 2:61478935-61478935 4
47 COSM104236414 XPO1 prostate,NS,carcinoma,adenocarcinoma c.1259T>C p.M420T 2:61493040-61493040 4
48 COSM101979599 XPO1 prostate,NS,carcinoma,adenocarcinoma c.1384G>T p.V462F 2:61492915-61492915 4
49 COSM101981883 XPO1 prostate,NS,carcinoma,adenocarcinoma c.1098T>A p.F366L 2:61494041-61494041 4
50 COSM104888806 XPO1 prostate,NS,carcinoma,adenocarcinoma c.1098T>A p.F366L 2:61494041-61494041 4

Expression for Prostate Cancer, Hereditary, 11

Search GEO for disease gene expression data for Prostate Cancer, Hereditary, 11.

Pathways for Prostate Cancer, Hereditary, 11

GO Terms for Prostate Cancer, Hereditary, 11

Sources for Prostate Cancer, Hereditary, 11

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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