HPC13
MCID: PRS071
MIFTS: 25

Prostate Cancer, Hereditary, 13 (HPC13)

Categories: Cancer diseases, Genetic diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Prostate Cancer, Hereditary, 13

MalaCards integrated aliases for Prostate Cancer, Hereditary, 13:

Name: Prostate Cancer, Hereditary, 13 57 73 29 13 6 71
Hpc13 57 73
Cancer, Prostate, Hereditary, Type 13 39
Familial Prostate Cancer 13 73

Classifications:



External Ids:

OMIM® 57 611928
MeSH 44 D011471
MedGen 41 C2677821
UMLS 71 C2677821

Summaries for Prostate Cancer, Hereditary, 13

UniProtKB/Swiss-Prot : 73 Prostate cancer, hereditary, 13: A condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.

MalaCards based summary : Prostate Cancer, Hereditary, 13, is also known as hpc13. An important gene associated with Prostate Cancer, Hereditary, 13 is MSMB (Microseminoprotein Beta). Affiliated tissues include prostate.

More information from OMIM: 611928

Related Diseases for Prostate Cancer, Hereditary, 13

Symptoms & Phenotypes for Prostate Cancer, Hereditary, 13

Clinical features from OMIM®:

611928 (Updated 05-Mar-2021)

Drugs & Therapeutics for Prostate Cancer, Hereditary, 13

Search Clinical Trials , NIH Clinical Center for Prostate Cancer, Hereditary, 13

Genetic Tests for Prostate Cancer, Hereditary, 13

Genetic tests related to Prostate Cancer, Hereditary, 13:

# Genetic test Affiliating Genes
1 Prostate Cancer, Hereditary, 13 29 MSMB

Anatomical Context for Prostate Cancer, Hereditary, 13

MalaCards organs/tissues related to Prostate Cancer, Hereditary, 13:

40
Prostate

Publications for Prostate Cancer, Hereditary, 13

Articles related to Prostate Cancer, Hereditary, 13:

# Title Authors PMID Year
1
Comprehensive resequence analysis of a 97 kb region of chromosome 10q11.2 containing the MSMB gene associated with prostate cancer. 6 57
19644707 2009
2
Fine mapping and functional analysis of a common variant in MSMB on chromosome 10q11.2 associated with prostate cancer susceptibility. 6 57
19383797 2009
3
Multiple loci identified in a genome-wide association study of prostate cancer. 57 6
18264096 2008
4
Multiple newly identified loci associated with prostate cancer susceptibility. 6 57
18264097 2008
5
Fine mapping association study and functional analysis implicate a SNP in MSMB at 10q11 as a causal variant for prostate cancer risk. 6
19153072 2009
6
Prognostic value of prostate secretory protein of 94 amino acids and its binding protein after radical prostatectomy. 57
17062675 2006
7
Strong bias in the location of functional promoter polymorphisms. 57
16086313 2005

Variations for Prostate Cancer, Hereditary, 13

ClinVar genetic disease variations for Prostate Cancer, Hereditary, 13:

6
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 MSMB NM_002443.3(MSMB):c.-89T= SNV risk factor 14244 rs10993994 10:51549496-51549496 10:46046326-46046326

Cosmic variations for Prostate Cancer, Hereditary, 13:

9 (show top 50) (show all 7592)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM87273255 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.8849G>A p.R2950H 16:72793833-72793833 12
2 COSM87278310 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.5650G>T p.E1884* 16:72797032-72797032 12
3 COSM102023521 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.598C>T p.R200* 16:72889839-72889839 12
4 COSM102020948 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.791C>A p.S264* 16:72812035-72812035 12
5 COSM102027229 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.2908G>T p.E970* 16:72797032-72797032 12
6 COSM149310968 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.5893C>T p.Q1965* 16:72796789-72796789 12
7 COSM87289963 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.2728G>A p.E910K 16:72950957-72950957 12
8 COSM87277276 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.2986A>T p.K996* 16:72950699-72950699 12
9 COSM102022171 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.6107G>A p.R2036H 16:72793833-72793833 12
10 COSM102025889 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.244A>T p.K82* 16:72950699-72950699 12
11 COSM149331699 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.5114C>G p.S1705* 16:72797568-72797568 12
12 COSM87287233 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.4819C>T p.Q1607* 16:72797863-72797863 12
13 COSM87296500 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.5114C>G p.S1705* 16:72797568-72797568 12
14 COSM149269669 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.3340C>T p.R1114* 16:72889839-72889839 12
15 COSM87271970 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.3533C>A p.S1178* 16:72812035-72812035 12
16 COSM149281678 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.5650G>T p.E1884* 16:72797032-72797032 12
17 COSM149265910 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.8849G>A p.R2950H 16:72793833-72793833 12
18 COSM87274612 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.3340C>T p.R1114* 16:72889839-72889839 12
19 COSM102031608 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.-23-8776C>G p.? 16:72959741-72959741 12
20 COSM149307401 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.4819C>T p.Q1607* 16:72797863-72797863 12
21 COSM87288892 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.5893C>T p.Q1965* 16:72796789-72796789 12
22 COSM149287761 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.6445C>T p.R2149C 16:72796237-72796237 12
23 COSM102037736 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.2077C>T p.Q693* 16:72797863-72797863 12
24 COSM149262752 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.3533C>A p.S1178* 16:72812035-72812035 12
25 COSM87281944 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.405C>G p.Y135* 16:72959741-72959741 12
26 COSM102047721 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.2372C>G p.S791* 16:72797568-72797568 12
27 COSM102029776 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.3703C>T p.R1235C 16:72796237-72796237 12
28 COSM87280241 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.6445C>T p.R2149C 16:72796237-72796237 12
29 COSM149314230 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.2728G>A p.E910K 16:72950957-72950957 12
30 COSM149278210 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.2986A>T p.K996* 16:72950699-72950699 12
31 COSM102039151 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.3151C>T p.Q1051* 16:72796789-72796789 12
32 COSM102040223 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.-15G>A p.? 16:72950957-72950957 12
33 COSM149292073 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.405C>G p.Y135* 16:72959741-72959741 12
34 COSM89894202 YES1 prostate,NS,carcinoma,adenocarcinoma c.119C>G p.S40* 18:756709-756709 12
35 COSM136834926 YES1 prostate,NS,carcinoma,adenocarcinoma c.590-1G>T p.? 18:745858-745858 12
36 COSM152021810 YES1 prostate,NS,carcinoma,adenocarcinoma c.575-1G>T p.? 18:745858-745858 12
37 COSM152022004 YES1 prostate,NS,carcinoma,adenocarcinoma c.119C>G p.S40* 18:756709-756709 12
38 COSM136836036 YES1 prostate,NS,carcinoma,adenocarcinoma c.134C>G p.S45* 18:756709-756709 12
39 COSM89892790 YES1 prostate,NS,carcinoma,adenocarcinoma c.575-1G>T p.? 18:745858-745858 12
40 COSM104882949 XPO1 prostate,NS,carcinoma,adenocarcinoma c.1259T>C p.M420T 2:61493040-61493040 12
41 COSM104239299 XPO1 prostate,NS,carcinoma,adenocarcinoma c.1384G>T p.V462F 2:61492915-61492915 12
42 COSM101975701 XPO1 prostate,NS,carcinoma,adenocarcinoma c.1711G>A p.E571K 2:61492337-61492337 12
43 COSM101977073 XPO1 prostate,NS,carcinoma,adenocarcinoma c.1259T>C p.M420T 2:61493040-61493040 12
44 COSM101976154 XPO1 prostate,NS,carcinoma,adenocarcinoma c.2468T>G p.F823C 2:61485808-61485808 12
45 COSM104881227 XPO1 prostate,NS,carcinoma,adenocarcinoma c.1711G>A p.E571K 2:61492337-61492337 12
46 COSM104238027 XPO1 prostate,NS,carcinoma,adenocarcinoma c.3101T>G p.F1034C 2:61478935-61478935 12
47 COSM104236414 XPO1 prostate,NS,carcinoma,adenocarcinoma c.1259T>C p.M420T 2:61493040-61493040 12
48 COSM101979599 XPO1 prostate,NS,carcinoma,adenocarcinoma c.1384G>T p.V462F 2:61492915-61492915 12
49 COSM101981883 XPO1 prostate,NS,carcinoma,adenocarcinoma c.1098T>A p.F366L 2:61494041-61494041 12
50 COSM104888806 XPO1 prostate,NS,carcinoma,adenocarcinoma c.1098T>A p.F366L 2:61494041-61494041 12

Expression for Prostate Cancer, Hereditary, 13

Search GEO for disease gene expression data for Prostate Cancer, Hereditary, 13.

Pathways for Prostate Cancer, Hereditary, 13

GO Terms for Prostate Cancer, Hereditary, 13

Sources for Prostate Cancer, Hereditary, 13

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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