HPC13
MCID: PRS071
MIFTS: 25

Prostate Cancer, Hereditary, 13 (HPC13)

Categories: Cancer diseases, Genetic diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Prostate Cancer, Hereditary, 13

MalaCards integrated aliases for Prostate Cancer, Hereditary, 13:

Name: Prostate Cancer, Hereditary, 13 56 73 29 13 6 71
Hpc13 56 73
Cancer, Prostate, Hereditary, Type 13 39
Familial Prostate Cancer 13 73

Classifications:



External Ids:

OMIM 56 611928
MeSH 43 D011471
MedGen 41 C2677821
UMLS 71 C2677821

Summaries for Prostate Cancer, Hereditary, 13

UniProtKB/Swiss-Prot : 73 Prostate cancer, hereditary, 13: A condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.

MalaCards based summary : Prostate Cancer, Hereditary, 13, is also known as hpc13. An important gene associated with Prostate Cancer, Hereditary, 13 is MSMB (Microseminoprotein Beta). Affiliated tissues include prostate.

More information from OMIM: 611928

Related Diseases for Prostate Cancer, Hereditary, 13

Symptoms & Phenotypes for Prostate Cancer, Hereditary, 13

Clinical features from OMIM:

611928

Drugs & Therapeutics for Prostate Cancer, Hereditary, 13

Search Clinical Trials , NIH Clinical Center for Prostate Cancer, Hereditary, 13

Genetic Tests for Prostate Cancer, Hereditary, 13

Genetic tests related to Prostate Cancer, Hereditary, 13:

# Genetic test Affiliating Genes
1 Prostate Cancer, Hereditary, 13 29 MSMB

Anatomical Context for Prostate Cancer, Hereditary, 13

MalaCards organs/tissues related to Prostate Cancer, Hereditary, 13:

40
Prostate

Publications for Prostate Cancer, Hereditary, 13

Articles related to Prostate Cancer, Hereditary, 13:

# Title Authors PMID Year
1
Comprehensive resequence analysis of a 97 kb region of chromosome 10q11.2 containing the MSMB gene associated with prostate cancer. 56 6
19644707 2009
2
Fine mapping and functional analysis of a common variant in MSMB on chromosome 10q11.2 associated with prostate cancer susceptibility. 6 56
19383797 2009
3
Multiple loci identified in a genome-wide association study of prostate cancer. 6 56
18264096 2008
4
Multiple newly identified loci associated with prostate cancer susceptibility. 56 6
18264097 2008
5
Fine mapping association study and functional analysis implicate a SNP in MSMB at 10q11 as a causal variant for prostate cancer risk. 6
19153072 2009
6
Prognostic value of prostate secretory protein of 94 amino acids and its binding protein after radical prostatectomy. 56
17062675 2006
7
Strong bias in the location of functional promoter polymorphisms. 56
16086313 2005

Variations for Prostate Cancer, Hereditary, 13

ClinVar genetic disease variations for Prostate Cancer, Hereditary, 13:

6 ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 MSMB NM_002443.3(MSMB):c.-89T=SNV risk factor 14244 rs10993994 10:51549496-51549496 10:46046326-46046326

Cosmic variations for Prostate Cancer, Hereditary, 13:

9 (show top 50) (show all 7592)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM149310968 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.5893C>T p.Q1965* 16:72796789-72796789 15
2 COSM149331699 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.5114C>G p.S1705* 16:72797568-72797568 15
3 COSM149269669 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.3340C>T p.R1114* 16:72889839-72889839 15
4 COSM149281678 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.5650G>T p.E1884* 16:72797032-72797032 15
5 COSM149265910 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.8849G>A p.R2950H 16:72793833-72793833 15
6 COSM149307401 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.4819C>T p.Q1607* 16:72797863-72797863 15
7 COSM149287761 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.6445C>T p.R2149C 16:72796237-72796237 15
8 COSM149262752 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.3533C>A p.S1178* 16:72812035-72812035 15
9 COSM149314230 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.2728G>A p.E910K 16:72950957-72950957 15
10 COSM149278210 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.2986A>T p.K996* 16:72950699-72950699 15
11 COSM149292073 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.405C>G p.Y135* 16:72959741-72959741 15
12 COSM152021810 YES1 prostate,NS,carcinoma,adenocarcinoma c.575-1G>T p.? 18:745858-745858 15
13 COSM152022004 YES1 prostate,NS,carcinoma,adenocarcinoma c.119C>G p.S40* 18:756709-756709 15
14 COSM101975701 XPO1 prostate,NS,carcinoma,adenocarcinoma c.1711G>A p.E571K 2:61492337-61492337 15
15 COSM101977073 XPO1 prostate,NS,carcinoma,adenocarcinoma c.1259T>C p.M420T 2:61493040-61493040 15
16 COSM101976154 XPO1 prostate,NS,carcinoma,adenocarcinoma c.2468T>G p.F823C 2:61485808-61485808 15
17 COSM101979599 XPO1 prostate,NS,carcinoma,adenocarcinoma c.1384G>T p.V462F 2:61492915-61492915 15
18 COSM101981883 XPO1 prostate,NS,carcinoma,adenocarcinoma c.1098T>A p.F366L 2:61494041-61494041 15
19 COSM101978581 XPO1 prostate,NS,carcinoma,adenocarcinoma c.3101T>G p.F1034C 2:61478935-61478935 15
20 COSM86795132 XPC prostate,NS,carcinoma,adenocarcinoma c.2200G>A p.G734S 3:14148864-14148864 15
21 COSM91367724 WT1 prostate,NS,carcinoma,adenocarcinoma c.1501C>T p.R501C 11:32389111-32389111 15
22 COSM91367638 WT1 prostate,NS,carcinoma,adenocarcinoma c.994C>G p.Q332E 11:32416497-32416497 15
23 COSM91376184 WT1 prostate,NS,carcinoma,adenocarcinoma c.1108C>T p.R370C 11:32396398-32396398 15
24 COSM91381446 WT1 prostate,NS,carcinoma,adenocarcinoma c.1353C>A p.F451L 11:32392051-32392051 15
25 COSM98492529 WAS prostate,NS,carcinoma,adenocarcinoma c.847G>A p.D283N 23:48688369-48688369 15
26 COSM88303023 VHL prostate,NS,carcinoma,adenocarcinoma c.242C>A p.P81Q 3:10142089-10142089 15
27 COSM88299216 VHL prostate,NS,carcinoma,adenocarcinoma c.219G>C p.Q73H 3:10142066-10142066 15
28 COSM88294223 VHL prostate,NS,carcinoma,adenocarcinoma c.499C>T p.R167W 3:10149822-10149822 15
29 COSM85193879 U2AF1 prostate,NS,carcinoma,adenocarcinoma c.692C>T p.S231L 21:43093133-43093133 15
30 COSM130300971 TYK2 prostate,NS,carcinoma,adenocarcinoma c.698G>A p.R233H 19:10365830-10365830 15
31 COSM87235561 TWF2 prostate,NS,carcinoma,adenocarcinoma c.1050G>T p.*350Yext*41 3:52229034-52229034 15
32 COSM87038387 TSC2 prostate,NS,carcinoma,adenocarcinoma c.4388T>A p.I1463N 16:2084610-2084610 15
33 COSM87046748 TSC2 prostate,NS,carcinoma,adenocarcinoma c.472G>A p.E158K 16:2054431-2054431 15
34 COSM87032748 TSC2 prostate,NS,carcinoma,adenocarcinoma c.1385G>A p.R462H 16:2062995-2062995 15
35 COSM87040966 TSC2 prostate,NS,carcinoma,adenocarcinoma c.392C>A p.P131H 16:2054351-2054351 15
36 COSM85719651 TSC1 prostate,NS,carcinoma,adenocarcinoma c.3100G>T p.G1034C 9:132896630-132896630 15
37 COSM85726617 TSC1 prostate,NS,carcinoma,adenocarcinoma c.508G>T p.G170C 9:132923348-132923348 15
38 COSM85719697 TSC1 prostate,NS,carcinoma,adenocarcinoma c.439G>T p.G147W 9:132923417-132923417 15
39 COSM88663750 TP63 prostate,NS,carcinoma,adenocarcinoma c.1106A>G p.K369R 3:189868693-189868693 15
40 COSM88650394 TP63 prostate,NS,carcinoma,adenocarcinoma c.1147C>T p.H383Y 3:189869341-189869341 15
41 COSM88644684 TP63 prostate,NS,carcinoma,adenocarcinoma c.728G>A p.R243Q 3:189864380-189864380 15
42 COSM88646095 TP63 prostate,NS,carcinoma,adenocarcinoma c.448G>A p.A150T 3:189808395-189808395 15
43 COSM88653018 TP63 prostate,NS,carcinoma,adenocarcinoma c.490G>A p.A164T 3:189808437-189808437 15
44 COSM87931229 TP53 prostate,NS,carcinoma,adenocarcinoma c.313G>T p.G105C 17:7676056-7676056 15
45 COSM87898431 TP53 prostate,NS,carcinoma,adenocarcinoma c.451C>T p.P151S 17:7675161-7675161 15
46 COSM87898714 TP53 prostate,NS,carcinoma,adenocarcinoma c.844C>T p.R282W 17:7673776-7673776 15
47 COSM88010014 TP53 prostate,NS,carcinoma,adenocarcinoma c.604C>T p.R202C 17:7674927-7674927 15
48 COSM87954983 TP53 prostate,NS,carcinoma,adenocarcinoma c.823T>G p.C275G 17:7673797-7673797 15
49 COSM87961560 TP53 prostate,NS,carcinoma,adenocarcinoma c.461G>A p.G154D 17:7675151-7675151 15
50 COSM88075013 TP53 prostate,NS,carcinoma,adenocarcinoma c.703A>C p.N235H 17:7674260-7674260 15

Expression for Prostate Cancer, Hereditary, 13

Search GEO for disease gene expression data for Prostate Cancer, Hereditary, 13.

Pathways for Prostate Cancer, Hereditary, 13

GO Terms for Prostate Cancer, Hereditary, 13

Sources for Prostate Cancer, Hereditary, 13

3 CDC
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11 DGIdb
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63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
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72 UMLS via Orphanet
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