MCID: PRS136
MIFTS: 40

Prostate Cancer, Hereditary, 6

Categories: Cancer diseases, Genetic diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Prostate Cancer, Hereditary, 6

MalaCards integrated aliases for Prostate Cancer, Hereditary, 6:

Name: Prostate Cancer, Hereditary, 6 58 13 74
Prostate Cancer, Susceptibility to 58
Prostate Cancer 58
Hpc6 58

Classifications:



External Ids:

OMIM 58 609558
MedGen 43 C1836005
UMLS 74 C1836005

Summaries for Prostate Cancer, Hereditary, 6

MalaCards based summary : Prostate Cancer, Hereditary, 6, also known as prostate cancer, susceptibility to, is related to prostate cancer and prostate cancer, hereditary, 8. An important gene associated with Prostate Cancer, Hereditary, 6 is HPC6 (Prostate Cancer, Susceptibility To). The drugs Selenium and Antioxidants have been mentioned in the context of this disorder. Affiliated tissues include prostate, bone and lymph node.

Description from OMIM: 609558

Related Diseases for Prostate Cancer, Hereditary, 6

Diseases in the Prostate Cancer family:

Prostate Cancer, Hereditary, 1 Prostate Cancer, Hereditary, 8
Prostate Cancer, Hereditary, 3 Prostate Cancer, Hereditary, 4
Prostate Cancer, Hereditary, 5 Prostate Cancer, Hereditary, 6
Prostate Cancer, Hereditary, 7 Prostate Cancer, Hereditary, 9
Prostate Cancer, Hereditary, 10 Prostate Cancer, Hereditary, 12
Prostate Cancer, Hereditary, 13 Prostate Cancer, Hereditary, 11
Prostate Cancer, Hereditary, 14 Prostate Cancer, Hereditary, 15
Prostate Cancer, Hereditary, 2 Prostate Carcinoma in Situ

Diseases related to Prostate Cancer, Hereditary, 6 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 584)
# Related Disease Score Top Affiliating Genes
1 prostate cancer 13.1
2 prostate cancer, hereditary, 8 12.7
3 prostate cancer, hereditary, 1 12.7
4 prostate cancer, hereditary, 2 12.6
5 prostate cancer, hereditary, 13 12.6
6 prostate cancer, hereditary, 12 12.6
7 prostate cancer, hereditary, 4 12.6
8 prostate cancer, hereditary, 11 12.5
9 prostate cancer, hereditary, 7 12.4
10 prostate cancer, hereditary, 3 12.4
11 prostate cancer/brain cancer susceptibility 12.4
12 prostate cancer, hereditary, x-linked 1 12.4
13 prostate cancer, hereditary, 9 12.4
14 prostate cancer, hereditary, x-linked 2 12.2
15 prostate cancer, hereditary, 5 12.2
16 prostate cancer, hereditary, 10 12.2
17 prostate cancer, hereditary, 14 12.2
18 prostate cancer, hereditary, 15 12.2
19 prostate cancer, progression and metastasis of 12.1
20 prostate cancer aggressiveness quantitative trait locus on chromosome 19 12.1
21 prostate disease 11.5
22 radiation proctitis 11.4
23 prostate sarcoma 11.1
24 brca1 hereditary breast and ovarian cancer syndrome 11.1
25 brca2 hereditary breast and ovarian cancer syndrome 11.1
26 diethylstilbestrol syndrome 11.1
27 pachyonychia congenita 3 10.9
28 prostatic hyperplasia, benign 10.9
29 colorectal adenoma 10.9
30 prostatic adenoma 10.8
31 patulous eustachian tube 10.8
32 hypoxia 10.7
33 impotence 10.6
34 insulin-like growth factor i 10.6
35 prostatitis 10.5
36 breast cancer 10.5
37 renal oncocytoma 10.5
38 chronic interstitial cystitis 10.5
39 leukemia 10.5
40 retinoblastoma 10.5
41 adenocarcinoma 10.5
42 bladder cancer 10.4
43 osteoporosis 10.4
44 body mass index quantitative trait locus 1 10.4
45 sexual disorder 10.4
46 hypogonadism 10.4
47 hypogonadotropism 10.4
48 prostatic hypertrophy 10.4
49 depression 10.4
50 disseminated intravascular coagulation 10.4

Graphical network of the top 20 diseases related to Prostate Cancer, Hereditary, 6:



Diseases related to Prostate Cancer, Hereditary, 6

Symptoms & Phenotypes for Prostate Cancer, Hereditary, 6

Clinical features from OMIM:

609558

Drugs & Therapeutics for Prostate Cancer, Hereditary, 6

Drugs for Prostate Cancer, Hereditary, 6 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Selenium Approved, Investigational, Vet_approved Phase 1 7782-49-2
2 Antioxidants Phase 1
3 Protective Agents Phase 1
4 Nutrients Phase 1
5 Micronutrients Phase 1
6 Trace Elements Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Selenium in Treating Patients Who Are Undergoing Brachytherapy for Stage I or Stage II Prostate Cancer Completed NCT00217516 Phase 1 selenium
2 An Exploration of Genetic Testing for Prostate Cancer Susceptibility Unknown status NCT00997464
3 Application of Genetic Polymorphisms of DNA Repair in The Prediction of Prostate Cancer Susceptibility and Its Clinical Outcome Unknown status NCT00167024
4 Identification of Prostate Cancer Genes Completed NCT00342784
5 Genetic Evaluation of Men (GEM) Recruiting NCT03076242

Search NIH Clinical Center for Prostate Cancer, Hereditary, 6

Genetic Tests for Prostate Cancer, Hereditary, 6

Anatomical Context for Prostate Cancer, Hereditary, 6

MalaCards organs/tissues related to Prostate Cancer, Hereditary, 6:

42
Prostate, Bone, Lymph Node, Endothelial, Testes, T Cells, Pituitary

Publications for Prostate Cancer, Hereditary, 6

Articles related to Prostate Cancer, Hereditary, 6:

(show top 50) (show all 22365)
# Title Authors Year
1
Combined maternal and post-weaning high fat diet inhibits male offspring's prostate cancer tumorigenesis in transgenic adenocarcinoma of mouse prostate model. ( 30614041 )
2019
2
Establishing a common metric for self-reported anxiety in patients with prostate cancer: Linking the Memorial Anxiety Scale for Prostate Cancer with PROMIS Anxiety. ( 31090933 )
2019
3
Parallel and serial mediation analysis between pain, anxiety, depression, fatigue and nausea, vomiting and retching within a randomised controlled trial in patients with breast and prostate cancer. ( 30679301 )
2019
4
Prostate cancer-specific anxiety and the resulting health-related quality of life in couples. ( 30132975 )
2019
5
Examining trajectories of anxiety in men with prostate cancer faced with complex treatment decisions. ( 30014194 )
2019
6
Impact of prostate cancer radiotherapy on the biological behavior and specific mortality of subsequent bladder cancer. ( 30903422 )
2019
7
High prevalence of secondary bladder cancer in men on radiotherapy for prostate cancer: evidence from a meta-analysis. ( 30666156 )
2019
8
Re: Marco Moschini, Emanuele Zaffuto, Pierre I. Karakiewicz, et al. External Beam Radiotherapy Increases the Risk of Bladder Cancer When Compared with Radical Prostatectomy in Patients Affected by Prostate Cancer: A Population-based Analysis. Eur Urol 2019;75:319-28. ( 30473434 )
2019
9
Re: Marco Moschini, Emanuele Zaffuto, Pierre I. Karakiewicz, et al. External Beam Radiotherapy Increases the Risk of Bladder Cancer When Compared with Radical Prostatectomy in Patients Affected by Prostate Cancer: A Population-based Analysis. Eur Urol 2019;75:319-28: Radiation Therapy Versus Radical Prostatectomy: No Way Out Without a Randomized Trial. ( 30502105 )
2019
10
Reply to Nicholas G. Zaorsky, Daniel E. Spratt, and Pierre Blanchard's Letter to the Editor re: Marco Moschini, Emanuele Zaffuto, Pierre I. Karakiewicz, et al. External Beam Radiotherapy Increases the Risk of Bladder Cancer When Compared with Radical Prostatectomy in Patients Affected by Prostate Cancer: A Population-based Analysis. Eur Urol 2019;75:319-28. ( 30503180 )
2019
11
Reply to Alba Fiorentino, Angelo Errico, and Marcello Scarcia's Letter to the Editor re: Marco Moschini, Emanuele Zaffuto, Pierre I. Karakiewicz, et al. External Beam Radiotherapy Increases the Risk of Bladder Cancer When Compared with Radical Prostatectomy in Patients Affected by Prostate Cancer: A Population-based Analysis. Eur Urol 2019;75:319-28: Radiation Therapy Versus Radical Prostatectomy: No Way Out Without a Randomized Trial. ( 30509762 )
2019
12
External Beam Radiotherapy Increases the Risk of Bladder Cancer When Compared with Radical Prostatectomy in Patients Affected by Prostate Cancer: A Population-based Analysis. ( 30293908 )
2019
13
A Synchronous Diagnosis of Metastatic Male Breast Cancer and Prostate Cancer. ( 31053047 )
2019
14
A Comparative Study of Google Search Trends for Melanoma, Breast Cancer and Prostate Cancer in Finland. ( 30999301 )
2019
15
Androgen receptor in breast cancer: a wolf in sheep's clothing? A lesson from prostate cancer. ( 31002873 )
2019
16
Chlamydia trachomatis Growth and Cytokine mRNA Response in a Prostate Cancer Cell Line. ( 30800160 )
2019
17
A rare case of tumor-to-tumor metastasis: Prostate cancer to chromophobe renal cell carcinoma. ( 30505689 )
2019
18
Androgen deprivation therapy for prostate cancer and risk of dementia. ( 30637900 )
2019
19
Statin reduces the risk of dementia in diabetic patients receiving androgen deprivation therapy for prostate cancer. ( 30337635 )
2019
20
Patterns and predictors of self-reported clinical diagnosis and treatment for depression in prostate cancer survivors. ( 31106980 )
2019
21
Re: Rano Matta, Christopher J.D. Wallis, Mitchell G. Goldenberg, et al. Variation and Trends in Antidepressant Prescribing for Men Undergoing Treatment for Nonmetastatic Prostate Cancer: A Population-based Cohort Study. Eur Urol 2019;75:3-7: Translational Potential of Dual Detection: Depression Diagnosis plus Sense of Coherence Determination in Prostate Cancer. ( 30732926 )
2019
22
Spirit-Quieting Traditional Chinese Medicine may Improve Survival in Prostate Cancer Patients with Depression. ( 30744039 )
2019
23
Androgen deprivation therapy and depression in men with prostate cancer treated with definitive radiation therapy: A psychological perspective. ( 30747996 )
2019
24
Androgen deprivation therapy and depression in men with prostate cancer treated with definitive radiation therapy. ( 30748008 )
2019
25
Educational level and the risk of depression after prostate cancer. ( 30700197 )
2019
26
Behavior Issues, Skin Cancer, Adolescent Depression, Prostate Cancer, Deprescribing Antipsychotics. ( 30702247 )
2019
27
The relationship between androgen deprivation therapy and depression symptoms in patients with prostate cancer. ( 30651026 )
2019
28
Depression Stresses the Immune Response and Promotes Prostate Cancer Growth. ( 30670491 )
2019
29
Depression and prostate cancer: A focused review for the clinician. ( 30630735 )
2019
30
Deciphering the scalene association among type-2 diabetes mellitus, prostate cancer, and chronic myeloid leukemia via enrichment analysis of disease-gene network. ( 30938105 )
2019
31
Effects of diabetes mellitus and Metformin administration on prostate cancer detection at biopsy among Chinese men: a case-control study. ( 30941974 )
2019
32
A case of synchronous advanced gastric cancer and locally advanced prostate cancer with combined laparoscopic and robotic surgery: A case report. ( 30852372 )
2019
33
Malignant jejunal gastrointestinal stromal tumor with history of prostate cancer: A case report. ( 31045773 )
2019
34
Statins Use and the Risk of Prostate Cancer in Ischemic Heart Disease Patients in Taiwan. ( 30801679 )
2019
35
Rapid resolution of prostate cancer-related hemolytic uremic syndrome without plasma exchange - a case report. ( 31085156 )
2019
36
A Rare Case of Liver Metastasis from Prostate Cancer Mimicking Hepatocellular Carcinoma on Immunohistochemistry: Role of F-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Diagnosis. ( 30713383 )
2019
37
Oncolytic Herpes Simplex Virus and PI3K Inhibitor BKM120 Synergize to Promote Killing of Prostate Cancer Stem-like Cells. ( 31016228 )
2019
38
Abiraterone and prednisone therapy may cause severe hypoglycemia when administered to prostate cancer patients with type 2 diabetes receiving glucose-lowering agents. ( 31065911 )
2019
39
Long-term treatment with testosterone undecanoate injections in men with hypogonadism alleviates erectile dysfunction and reduces risk of major adverse cardiovascular events, prostate cancer, and mortality. ( 30782054 )
2019
40
Testosterone Replacement Therapy for Patients with Hypogonadism after High Dose-Rate Brachytherapy for High-Risk Prostate Cancer: A Report of Six Cases and Literature Review. ( 31081296 )
2019
41
Hypoxia and angiogenic biomarkers in prostate cancer after external beam radiotherapy (EBRT) alone or combined with high-dose-rate brachytherapy boost (HDR-BTb). ( 31059955 )
2019
42
Nuclear FGFR2 negatively regulates hypoxia-induced cell invasion in prostate cancer by interacting with HIF-1 and HIF-2. ( 30837551 )
2019
43
Hypoxia Patterns in Primary and Metastatic Prostate Cancer Environments. ( 30639975 )
2019
44
Resveratrol integrates metabolic and growth effects in PC3 prostate cancer cells-involvement of prolyl hydroxylase and hypoxia inducible factor-1. ( 30655819 )
2019
45
Synthesis and Evaluation of Multifunctional Fluorescent Inhibitors with Synergistic Interaction of Prostate-Specific Membrane Antigen and Hypoxia for Prostate Cancer. ( 30485073 )
2019
46
Inflammatory Bowel Disease and the Risk of Prostate Cancer. ( 30528221 )
2019
47
Leukemia inhibitory factor promotes castration-resistant prostate cancer and neuroendocrine differentiation by activated ZBTB46. ( 30962287 )
2019
48
Rapid Development of Spinal Epidural Lipomatosis after Treatment of Metastatic Castration-resistant Prostate Cancer with Second-Generation Androgen Receptor Antagonists. ( 30763756 )
2019
49
Incidental finding of non-Hodgkin's lymphoma in a patient affected by castration-sensitive prostate cancer: A case report. ( 30882658 )
2019
50
Radiation-related Lymphopenia after Pelvic Nodal Irradiation for Prostate Cancer. ( 31011677 )
2019

Variations for Prostate Cancer, Hereditary, 6

Expression for Prostate Cancer, Hereditary, 6

Search GEO for disease gene expression data for Prostate Cancer, Hereditary, 6.

Pathways for Prostate Cancer, Hereditary, 6

GO Terms for Prostate Cancer, Hereditary, 6

Sources for Prostate Cancer, Hereditary, 6

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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