HPC6
MCID: PRS136
MIFTS: 40

Prostate Cancer, Hereditary, 6 (HPC6)

Categories: Cancer diseases, Genetic diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Prostate Cancer, Hereditary, 6

MalaCards integrated aliases for Prostate Cancer, Hereditary, 6:

Name: Prostate Cancer, Hereditary, 6 58 13 74
Prostate Cancer, Susceptibility to 58
Prostate Cancer 58
Hpc6 58

Classifications:



External Ids:

OMIM 58 609558
MedGen 43 C1836005
UMLS 74 C1836005

Summaries for Prostate Cancer, Hereditary, 6

MalaCards based summary : Prostate Cancer, Hereditary, 6, also known as prostate cancer, susceptibility to, is related to prostate cancer and prostate cancer, hereditary, 8. An important gene associated with Prostate Cancer, Hereditary, 6 is HPC6 (Prostate Cancer, Susceptibility To). The drugs Selenium and Antioxidants have been mentioned in the context of this disorder. Affiliated tissues include prostate, bone and breast.

Description from OMIM: 609558

Related Diseases for Prostate Cancer, Hereditary, 6

Diseases in the Prostate Cancer family:

Prostate Cancer, Hereditary, 1 Prostate Cancer, Hereditary, 8
Prostate Cancer, Hereditary, 3 Prostate Cancer, Hereditary, 4
Prostate Cancer, Hereditary, 5 Prostate Cancer, Hereditary, 6
Prostate Cancer, Hereditary, 7 Prostate Cancer, Hereditary, 9
Prostate Cancer, Hereditary, 10 Prostate Cancer, Hereditary, 12
Prostate Cancer, Hereditary, 13 Prostate Cancer, Hereditary, 11
Prostate Cancer, Hereditary, 14 Prostate Cancer, Hereditary, 15
Prostate Cancer, Hereditary, 2 Prostate Carcinoma in Situ

Diseases related to Prostate Cancer, Hereditary, 6 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 543)
# Related Disease Score Top Affiliating Genes
1 prostate cancer 13.0
2 prostate cancer, hereditary, 8 12.7
3 prostate cancer, hereditary, 1 12.6
4 prostate cancer, hereditary, 4 12.5
5 prostate cancer, hereditary, 2 12.5
6 prostate cancer, hereditary, 13 12.5
7 prostate cancer, hereditary, 12 12.5
8 prostate cancer, hereditary, 11 12.5
9 prostate cancer, hereditary, 7 12.4
10 prostate cancer, hereditary, 3 12.3
11 prostate cancer, hereditary, x-linked 1 12.2
12 prostate cancer/brain cancer susceptibility 12.2
13 prostate cancer, hereditary, 9 12.2
14 prostate cancer, hereditary, x-linked 2 12.2
15 prostate cancer, hereditary, 5 12.2
16 prostate cancer, hereditary, 10 12.2
17 prostate cancer, hereditary, 14 12.2
18 prostate cancer, hereditary, 15 12.2
19 prostate cancer, progression and metastasis of 12.1
20 prostate cancer aggressiveness quantitative trait locus on chromosome 19 12.1
21 prostate disease 11.4
22 radiation proctitis 11.4
23 prostate sarcoma 11.1
24 brca1 hereditary breast and ovarian cancer syndrome 11.1
25 brca2 hereditary breast and ovarian cancer syndrome 11.1
26 diethylstilbestrol syndrome 11.1
27 prostatic hyperplasia, benign 10.9
28 colorectal adenoma 10.9
29 patulous eustachian tube 10.8
30 pachyonychia congenita 3 10.8
31 hypoxia 10.7
32 prostatic adenoma 10.7
33 impotence 10.6
34 insulin-like growth factor i 10.6
35 prostatitis 10.5
36 breast cancer 10.5
37 renal oncocytoma 10.5
38 chronic interstitial cystitis 10.5
39 leukemia 10.5
40 adenocarcinoma 10.4
41 retinoblastoma 10.4
42 bladder cancer 10.4
43 osteoporosis 10.4
44 body mass index quantitative trait locus 1 10.4
45 sexual disorder 10.4
46 prostatic hypertrophy 10.4
47 hypogonadism 10.4
48 disseminated intravascular coagulation 10.4
49 depression 10.4
50 bone disease 10.3

Graphical network of the top 20 diseases related to Prostate Cancer, Hereditary, 6:



Diseases related to Prostate Cancer, Hereditary, 6

Symptoms & Phenotypes for Prostate Cancer, Hereditary, 6

Clinical features from OMIM:

609558

Drugs & Therapeutics for Prostate Cancer, Hereditary, 6

Drugs for Prostate Cancer, Hereditary, 6 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Selenium Approved, Investigational, Vet_approved Phase 1 7782-49-2
2 Antioxidants Phase 1
3 Nutrients Phase 1
4 Trace Elements Phase 1
5 Micronutrients Phase 1
6 Protective Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Selenium in Treating Patients Who Are Undergoing Brachytherapy for Stage I or Stage II Prostate Cancer Completed NCT00217516 Phase 1 selenium
2 An Exploration of Genetic Testing for Prostate Cancer Susceptibility Unknown status NCT00997464
3 Application of Genetic Polymorphisms of DNA Repair in The Prediction of Prostate Cancer Susceptibility and Its Clinical Outcome Unknown status NCT00167024
4 Identification of Prostate Cancer Genes Completed NCT00342784
5 Genetic Evaluation of Men (GEM) Recruiting NCT03076242

Search NIH Clinical Center for Prostate Cancer, Hereditary, 6

Genetic Tests for Prostate Cancer, Hereditary, 6

Anatomical Context for Prostate Cancer, Hereditary, 6

MalaCards organs/tissues related to Prostate Cancer, Hereditary, 6:

42
Prostate, Bone, Breast, Lymph Node, Endothelial, Testes, T Cells

Publications for Prostate Cancer, Hereditary, 6

Articles related to Prostate Cancer, Hereditary, 6:

(show top 50) (show all 21521)
# Title Authors Year
1
Combined maternal and post-weaning high fat diet inhibits male offspring's prostate cancer tumorigenesis in transgenic adenocarcinoma of mouse prostate model. ( 30614041 )
2019
2
Parallel and serial mediation analysis between pain, anxiety, depression, fatigue and nausea, vomiting and retching within a randomised controlled trial in patients with breast and prostate cancer. ( 30679301 )
2019
3
A Rare Case of Liver Metastasis from Prostate Cancer Mimicking Hepatocellular Carcinoma on Immunohistochemistry: Role of F-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Diagnosis. ( 30713383 )
2019
4
Impact of prostate cancer radiotherapy on the biological behavior and specific mortality of subsequent bladder cancer. ( 30903422 )
2019
5
High prevalence of secondary bladder cancer in men on radiotherapy for prostate cancer: evidence from a meta-analysis. ( 30666156 )
2019
6
External Beam Radiotherapy Increases the Risk of Bladder Cancer When Compared with Radical Prostatectomy in Patients Affected by Prostate Cancer: A Population-based Analysis. ( 30293908 )
2019
7
Chlamydia trachomatis Growth and Cytokine mRNA Response in a Prostate Cancer Cell Line. ( 30800160 )
2019
8
A rare case of tumor-to-tumor metastasis: Prostate cancer to chromophobe renal cell carcinoma. ( 30505689 )
2019
9
Androgen deprivation therapy for prostate cancer and risk of dementia. ( 30637900 )
2019
10
Re: Rano Matta, Christopher J.D. Wallis, Mitchell G. Goldenberg, et al. Variation and Trends in Antidepressant Prescribing for Men Undergoing Treatment for Nonmetastatic Prostate Cancer: A Population-based Cohort Study. Eur Urol 2019;75:3-7: Translational Potential of Dual Detection: Depression Diagnosis plus Sense of Coherence Determination in Prostate Cancer. ( 30732926 )
2019
11
Spirit-Quieting Traditional Chinese Medicine may Improve Survival in Prostate Cancer Patients with Depression. ( 30744039 )
2019
12
Androgen deprivation therapy and depression in men with prostate cancer treated with definitive radiation therapy: A psychological perspective. ( 30747996 )
2019
13
Androgen deprivation therapy and depression in men with prostate cancer treated with definitive radiation therapy. ( 30748008 )
2019
14
Educational level and the risk of depression after prostate cancer. ( 30700197 )
2019
15
Behavior Issues, Skin Cancer, Adolescent Depression, Prostate Cancer, Deprescribing Antipsychotics. ( 30702247 )
2019
16
The relationship between androgen deprivation therapy and depression symptoms in patients with prostate cancer. ( 30651026 )
2019
17
Depression stresses the immune response and promotes prostate cancer growth. ( 30670491 )
2019
18
Depression and prostate cancer: A focused review for the clinician. ( 30630735 )
2019
19
A case of synchronous advanced gastric cancer and locally advanced prostate cancer with combined laparoscopic and robotic surgery: A case report. ( 30852372 )
2019
20
Statins Use and the Risk of Prostate Cancer in Ischemic Heart Disease Patients in Taiwan. ( 30801679 )
2019
21
Long-term treatment with testosterone undecanoate injections in men with hypogonadism alleviates erectile dysfunction and reduces risk of major adverse cardiovascular events, prostate cancer, and mortality. ( 30782054 )
2019
22
Nuclear FGFR2 negatively regulates hypoxia-induced cell invasion in prostate cancer by interacting with HIF-1 and HIF-2. ( 30837551 )
2019
23
Resveratrol integrates metabolic and growth effects in PC3 prostate cancer cells-involvement of prolyl hydroxylase and hypoxia inducible factor-1. ( 30655819 )
2019
24
Hypoxia Patterns in Primary and Metastatic Prostate Cancer Environments. ( 30639975 )
2019
25
Rapid Development of Spinal Epidural Lipomatosis after Treatment of Metastatic Castration-resistant Prostate Cancer with Second-Generation Androgen Receptor Antagonists. ( 30763756 )
2019
26
Incidental finding of non-Hodgkin's lymphoma in a patient affected by castration-sensitive prostate cancer: A case report. ( 30882658 )
2019
27
Inhibition of mouse RM-1 prostate cancer and B16F10 melanoma by the fusion protein of HSP65 & STEAP1 186-193. ( 30841425 )
2019
28
Identification and characterization of small molecule inhibitors of the ubiquitin ligases Siah1/2 in melanoma and prostate cancer cells. ( 30771432 )
2019
29
Paraneoplastic Syndrome Secondary to Treatment Emergent Neuroendocrine Tumor in Metastatic Castration-resistant Prostate Cancer: A Unique Case. ( 30279116 )
2019
30
Neutropenia and docetaxel exposure in metastatic castration-resistant prostate cancer patients: A meta-analysis and evaluation of a clinical cohort. ( 30802002 )
2019
31
Preclinical development of a WT1 oral cancer vaccine using a bacterial vector to treat castration-resistant prostate cancer. ( 30824610 )
2019
32
Uncommon presentation of medication-related osteonecrosis of the mandible in a patient with metastatic prostate cancer. ( 30814104 )
2019
33
Osteoporosis and prostate cancer; a 24-month prospective observational study during androgen deprivation therapy. ( 30777478 )
2019
34
French recommendations for osteoporosis prevention and treatment in patients with prostate cancer treated by androgen deprivation. ( 30287350 )
2019
35
Vitamin K intake and prostate cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer (PLCO) Screening Trial. ( 30624568 )
2019
36
Advanced prostate cancer discovered with cancerous peritonitis: Case report. ( 30510901 )
2019
37
Safe usage of bicalutamide and goserelin in a male patient with acute intermittent porphyria and prostate cancer. ( 30714461 )
2019
38
The association of BRCA1 and BRCA2 mutations with prostate cancer risk, frequency, and mortality: A meta-analysis. ( 30900310 )
2019
39
Effectiveness of Bi-Parametric MR/US Fusion Biopsy for Detecting Clinically Significant Prostate Cancer in Prostate Biopsy Naïve Men. ( 30900420 )
2019
40
Magnetic resonance imaging radiomic feature analysis of radiation-induced femoral head changes in prostate cancer radiotherapy. ( 30900614 )
2019
41
Role of serum prostate-specific antigen as predictor for bone metastases in newly diagnosed prostate cancer. ( 30900618 )
2019
42
Effect of Au-197 nanoparticles along with Sm-153 radiopharmaceutical in prostate cancer from simulation method. ( 30900619 )
2019
43
The effect of metabolic syndrome on prostate cancer final pathology. ( 30900620 )
2019
44
Integrating systemic module inference with attract method excavates attractor modules for cyclophosphamide contributing to prostate cancer. ( 30900638 )
2019
45
Screening for prostate cancer starting at age 50-54 years. ( 30900644 )
2019
46
Enhanced Patient Activation in Cancer Care Transitions: Protocol for a Randomized Controlled Trial of a Tailored Electronic Health Intervention for Men With Prostate Cancer. ( 30900999 )
2019
47
Enhancing PSMA-uptake with androgen deprivation therapy - a new way to detect prostate cancer metastases? ( 30901173 )
2019
48
Development of Technologic Solutions to Address Complex Local Requirements of an International Prostate Cancer Clinical Quality Registry. ( 30901234 )
2019
49
Multidisciplinary Care in High-Risk Prostate Cancer Is the New Standard of Care. ( 30901303 )
2019
50
Characterization of the ERG-regulated Kinome in Prostate Cancer Identifies TNIK as a Potential Therapeutic Target. ( 30901730 )
2019

Variations for Prostate Cancer, Hereditary, 6

Expression for Prostate Cancer, Hereditary, 6

Search GEO for disease gene expression data for Prostate Cancer, Hereditary, 6.

Pathways for Prostate Cancer, Hereditary, 6

GO Terms for Prostate Cancer, Hereditary, 6

Sources for Prostate Cancer, Hereditary, 6

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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