HPC7
MCID: PRS080
MIFTS: 21

Prostate Cancer, Hereditary, 7 (HPC7)

Categories: Cancer diseases, Genetic diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Prostate Cancer, Hereditary, 7

MalaCards integrated aliases for Prostate Cancer, Hereditary, 7:

Name: Prostate Cancer, Hereditary, 7 57 13 70
Prostate Cancer Aggressiveness 57
Hpc7 57

Classifications:



External Ids:

OMIM® 57 610321
MedGen 41 C1853195
UMLS 70 C1853195

Summaries for Prostate Cancer, Hereditary, 7

MalaCards based summary : Prostate Cancer, Hereditary, 7, also known as prostate cancer aggressiveness, is related to prostate cancer aggressiveness quantitative trait locus on chromosome 19 and prostate cancer. An important gene associated with Prostate Cancer, Hereditary, 7 is HPC7 (Prostate Cancer, Hereditary, 7). The drugs Olaparib and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include prostate and colon.

More information from OMIM: 610321

Related Diseases for Prostate Cancer, Hereditary, 7

Diseases in the Prostate Cancer family:

Prostate Cancer, Hereditary, 1 Prostate Cancer, Hereditary, 8
Prostate Cancer, Hereditary, 3 Prostate Cancer, Hereditary, 4
Prostate Cancer, Hereditary, 5 Prostate Cancer, Hereditary, 6
Prostate Cancer, Hereditary, 7 Prostate Cancer, Hereditary, 9
Prostate Cancer, Hereditary, 10 Prostate Cancer, Hereditary, 12
Prostate Cancer, Hereditary, 13 Prostate Cancer, Hereditary, 11
Prostate Cancer, Hereditary, 14 Prostate Cancer, Hereditary, 15
Prostate Cancer, Hereditary, 2 Prostate Carcinoma in Situ

Diseases related to Prostate Cancer, Hereditary, 7 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)
# Related Disease Score Top Affiliating Genes
1 prostate cancer aggressiveness quantitative trait locus on chromosome 19 11.3
2 prostate cancer 10.9
3 prostatic hyperplasia, benign 10.3
4 prostatic hypertrophy 10.3
5 prostatic adenoma 10.3
6 pachyonychia congenita 3 10.2
7 hypercholesterolemia, familial, 1 10.1
8 hypoxia 10.1
9 schopf-schulz-passarge syndrome 10.0
10 body mass index quantitative trait locus 11 10.0
11 suppression of tumorigenicity 12 10.0
12 body mass index quantitative trait locus 9 10.0
13 body mass index quantitative trait locus 8 10.0
14 body mass index quantitative trait locus 4 10.0
15 body mass index quantitative trait locus 10 10.0
16 body mass index quantitative trait locus 7 10.0
17 body mass index quantitative trait locus 12 10.0
18 body mass index quantitative trait locus 14 10.0
19 graft-versus-host disease 10.0
20 body mass index quantitative trait locus 18 10.0
21 body mass index quantitative trait locus 19 10.0
22 rickets 10.0
23 squamous cell papilloma 10.0
24 vascular disease 10.0
25 papilloma 10.0
26 tic disorder 10.0
27 skin carcinoma 10.0
28 hyperglycemia 10.0
29 b-cell lymphoma 10.0
30 47,xyy 10.0
31 cytokine deficiency 10.0
32 acute sensory ataxic neuropathy 10.0

Graphical network of the top 20 diseases related to Prostate Cancer, Hereditary, 7:



Diseases related to Prostate Cancer, Hereditary, 7

Symptoms & Phenotypes for Prostate Cancer, Hereditary, 7

Clinical features from OMIM®:

610321 (Updated 05-Apr-2021)

Drugs & Therapeutics for Prostate Cancer, Hereditary, 7

Drugs for Prostate Cancer, Hereditary, 7 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Olaparib Approved Phase 2 763113-22-0 23725625
2
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
3
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
4 glucocorticoids Phase 2
5 Hormone Antagonists Phase 2
6 Hormones Phase 2
7 Antineoplastic Agents, Hormonal Phase 2
8 Anti-Inflammatory Agents Phase 2
9 Poly(ADP-ribose) Polymerase Inhibitors Phase 2
10 Immunologic Factors
11 Antibodies
12 Immunoglobulins
13 Antigen-Antibody Complex

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Phase II Study of Olaparib Maintenance Following Cabazitaxel-Carboplatin Induction Chemotherapy in Men With Aggressive Variant Prostate Cancer (AVPC) Active, not recruiting NCT03263650 Phase 2 Cabazitaxel;Carboplatin;Prednisone 5Mg;Olaparib
2 Development and Validation of Novel MRI Methods for the Detection of Prostate Cancer Aggressiveness Unknown status NCT02545881
3 Correlation Between Immune compleX Predictive Index and Prostate Cancer Aggressiveness at Radical Prostetecomy Specimens: a Multicenter Prospective Trial Unknown status NCT03413007
4 Imaging Prostatic Lipids to Distinguish Aggressive Prostate Cancer Completed NCT01780701
5 MRI for Assessment of Hypoxia-Induced Prostate Cancer Aggressiveness Recruiting NCT01464216
6 A Multi-center, Prospective Active Surveillance Registry Trial Assessing the Performance of a Non-invasive Immunogenomic Blood Test for Indolent Prostate Cancer Disease Management. Active, not recruiting NCT04052048

Search NIH Clinical Center for Prostate Cancer, Hereditary, 7

Genetic Tests for Prostate Cancer, Hereditary, 7

Anatomical Context for Prostate Cancer, Hereditary, 7

MalaCards organs/tissues related to Prostate Cancer, Hereditary, 7:

40
Prostate, Colon

Publications for Prostate Cancer, Hereditary, 7

Articles related to Prostate Cancer, Hereditary, 7:

# Title Authors PMID Year
1
Genome-wide linkage analyses of hereditary prostate cancer families with colon cancer provide further evidence for a susceptibility locus on 15q11-q14. 57
20407467 2010
2
Genome-wide linkage scan for prostate cancer susceptibility genes in men with aggressive disease: significant evidence for linkage at chromosome 15q12. 57
16508751 2006
3
Targeting the delivery of systemically administered haematopoietic stem/progenitor cells to the inflamed colon using hydrogen peroxide and platelet microparticle pre-treatment strategies. 61
26479027 2015
4
Itga2b regulation at the onset of definitive hematopoiesis and commitment to differentiation. 61
22952660 2012

Variations for Prostate Cancer, Hereditary, 7

Expression for Prostate Cancer, Hereditary, 7

Search GEO for disease gene expression data for Prostate Cancer, Hereditary, 7.

Pathways for Prostate Cancer, Hereditary, 7

GO Terms for Prostate Cancer, Hereditary, 7

Sources for Prostate Cancer, Hereditary, 7

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....