HPC9
MCID: PRS081
MIFTS: 17

Prostate Cancer, Hereditary, 9 (HPC9)

Categories: Cancer diseases, Genetic diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Prostate Cancer, Hereditary, 9

MalaCards integrated aliases for Prostate Cancer, Hereditary, 9:

Name: Prostate Cancer, Hereditary, 9 57 29 13 6 70
Cancer, Prostate, Hereditary, Type 9 39
Hpc9 57

Classifications:



External Ids:

OMIM® 57 610997
MedGen 41 C1970250
UMLS 70 C1970250

Summaries for Prostate Cancer, Hereditary, 9

MalaCards based summary : Prostate Cancer, Hereditary, 9, is also known as cancer, prostate, hereditary, type 9. An important gene associated with Prostate Cancer, Hereditary, 9 is HOXB13 (Homeobox B13). Affiliated tissues include prostate.

More information from OMIM: 610997

Related Diseases for Prostate Cancer, Hereditary, 9

Symptoms & Phenotypes for Prostate Cancer, Hereditary, 9

Clinical features from OMIM®:

610997 (Updated 20-May-2021)

Drugs & Therapeutics for Prostate Cancer, Hereditary, 9

Search Clinical Trials , NIH Clinical Center for Prostate Cancer, Hereditary, 9

Genetic Tests for Prostate Cancer, Hereditary, 9

Genetic tests related to Prostate Cancer, Hereditary, 9:

# Genetic test Affiliating Genes
1 Prostate Cancer, Hereditary, 9 29 HOXB13

Anatomical Context for Prostate Cancer, Hereditary, 9

MalaCards organs/tissues related to Prostate Cancer, Hereditary, 9:

40
Prostate

Publications for Prostate Cancer, Hereditary, 9

Articles related to Prostate Cancer, Hereditary, 9:

# Title Authors PMID Year
1
Germline mutations in HOXB13 and prostate-cancer risk. 57 6
22236224 2012
2
Association between germline homeobox B13 (HOXB13) G84E allele and prostate cancer susceptibility: a meta-analysis and trial sequential analysis. 6
27626483 2016
3
Imputation of the rare HOXB13 G84E mutation and cancer risk in a large population-based cohort. 6
25629170 2015
4
G84E mutation in HOXB13 is firmly associated with prostate cancer risk: a meta-analysis. 6
24026887 2014
5
A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 chromatin binding. 57
24390282 2014
6
A population-based assessment of germline HOXB13 G84E mutation and prostate cancer risk. 6
22841674 2014
7
HOXB13 is a susceptibility gene for prostate cancer: results from the International Consortium for Prostate Cancer Genetics (ICPCG). 6
23064873 2013
8
Fine-mapping the putative chromosome 17q21-22 prostate cancer susceptibility gene to a 10 cM region based on linkage analysis. 57
17120048 2007
9
Genome-wide scan for prostate cancer susceptibility genes using families from the University of Michigan prostate cancer genetics project finds evidence for linkage on chromosome 17 near BRCA1. 57
14601029 2003
10
Genetic heterogeneity in Finnish hereditary prostate cancer using ordered subset analysis. 61
22948022 2013

Variations for Prostate Cancer, Hereditary, 9

ClinVar genetic disease variations for Prostate Cancer, Hereditary, 9:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 HOXB13 NM_006361.5(HOXB13):c.251G>A (p.Gly84Glu) SNV Pathogenic 128031 rs138213197 GRCh37: 17:46805705-46805705
GRCh38: 17:48728343-48728343
2 HOXB13 NM_006361.5(HOXB13):c.832G>T (p.Val278Leu) SNV Uncertain significance 128038 rs200997384 GRCh37: 17:46804175-46804175
GRCh38: 17:48726813-48726813
3 HOXB13 NM_006361.5(HOXB13):c.526G>C (p.Gly176Arg) SNV Uncertain significance 485694 rs747003841 GRCh37: 17:46805430-46805430
GRCh38: 17:48728068-48728068
4 HOXB13 NM_006361.5(HOXB13):c.216G>T (p.Gly72=) SNV Uncertain significance 483502 rs769145488 GRCh37: 17:46805740-46805740
GRCh38: 17:48728378-48728378
5 HOXB13 NM_006361.5(HOXB13):c.140A>G (p.Asn47Ser) SNV Uncertain significance 483487 rs748333323 GRCh37: 17:46805816-46805816
GRCh38: 17:48728454-48728454

Expression for Prostate Cancer, Hereditary, 9

Search GEO for disease gene expression data for Prostate Cancer, Hereditary, 9.

Pathways for Prostate Cancer, Hereditary, 9

GO Terms for Prostate Cancer, Hereditary, 9

Sources for Prostate Cancer, Hereditary, 9

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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