Prostate Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: PRS042 MIFTS: 42	Prostate Disease Categories: Endocrine diseases, Nephrological diseases, Reproductive diseases
Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Prostate Disease

MalaCards integrated aliases for Prostate Disease:

Name: Prostate Disease ¹² ¹⁵

Prostatic Diseases ⁴⁴ ⁷³

Prostate Diseases ⁴³

Classifications:

MalaCards categories:
Anatomical: Reproductive diseases Nephrological diseases Endocrine diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the genitourinary system

Diseases of male genital organs

Disorders of male genital organs in diseases classified elsewhere

Disorders of prostate in diseases classified elsewhere

Other disorders of prostate

Disorder of prostate, unspecified

Other specified disorders of prostate

External Ids:

Disease Ontology ¹² DOID:47

ICD10 ³³ N42.9 N42 N42.8 more

ICD9CM ³⁵ 602.9

MeSH ⁴⁴ D011469

NCIt ⁵⁰ C26865

SNOMED-CT ⁶⁸ 30281009

UMLS ⁷³ C0033575

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Summaries for Prostate Disease

MedlinePlus : ⁴³ The prostate is a gland in men. It helps make semen, the fluid that contains sperm. The prostate surrounds the tube that carries urine away from the bladder and out of the body. A young man's prostate is about the size of a walnut. It slowly grows larger with age. If it gets too large, it can cause problems. This is very common after age 50. The older men get, the more likely they are to have prostate trouble. Some common problems are Prostatitis - inflammation, usually caused by bacteria Enlarged prostate (BPH), or benign prostatic hyperplasia - a common problem in older men which may cause dribbling after urination or a need to go often, especially at night Prostate cancer - a common cancer that responds best to treatment when detected early NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Prostate Disease, also known as prostatic diseases, is related to prostatic hyperplasia, benign and prostatic hypertrophy, and has symptoms including tremor, angina pectoris and equilibration disorder. An important gene associated with Prostate Disease is PCA3 (Prostate Cancer Associated 3). The drugs Iodine and Povidone have been mentioned in the context of this disorder. Affiliated tissues include prostate, kidney and testes.

Wikipedia : ⁷⁶ The prostate (from Ancient Greek �?ρο�?�?ά�?η�?, prostates, literally "one who stands before",... more...

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Related Diseases for Prostate Disease

Diseases related to Prostate Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)

#	Related Disease	Score	Top Affiliating Genes
1	prostatic hyperplasia, benign	30.1	AR CDKN2B-AS1 FOLH1 KLK3 SERPINA3
2	prostatic hypertrophy	29.6	AR KLK3
3	prostate cancer	29.5	AR CBR3-AS1 CDKN2B-AS1 CTBP1-AS FOLH1 GAS5
4	prostatitis	10.5
5	nodular prostate	10.3	AR FOLH1 KLK3
6	prostate small cell carcinoma	10.3	FOLH1 KLK3
7	suppression of tumorigenicity 12	10.3	AR FOLH1 KLK3
8	male reproductive organ cancer	10.3	AR FOLH1 KLK3 PCA3
9	male reproductive system disease	10.3	AR FOLH1 KLK3 PCA3
10	reproductive system disease	10.3	AR FOLH1 KLK3 PCA3
11	villous adenoma	10.3	FOLH1 KLK3
12	undifferentiated embryonal sarcoma of the liver	10.3	MALAT1 SERPINA3
13	embryonal sarcoma	10.3	MALAT1 SERPINA3
14	vulva squamous cell carcinoma	10.3	MALAT1 MEG3
15	testicular germ cell cancer	10.3	AR MEG3
16	gastric cardia adenocarcinoma	10.3	H19 MEG3
17	androgenic alopecia	10.2	AR KLK3
18	malignant glioma	10.2	CDKN2B-AS1 GAS5 PCGEM1 PRNCR1
19	breast cyst	10.2	KLK3 SERPINA3
20	pituitary adenoma	10.2	H19 MALAT1 MEG3
21	laryngeal squamous cell carcinoma	10.2	CDKN2B-AS1 H19 MALAT1
22	withdrawal disorder	10.2	AR KLK3
23	ovarian epithelial cancer	10.2	H19 MALAT1 MEG3 PCA3
24	bladder urothelial carcinoma	10.2	AR GAS5 KLK3 MALAT1 MEG3
25	thyroid cancer	10.2	CDKN2B-AS1 GAS5 H19 MALAT1
26	thyroid cancer, nonmedullary, 1	10.2	GAS5 H19 MALAT1 MEG3
27	osteoarthritis	10.2	GAS5 H19 MEG3 PCGEM1
28	kidney cancer	10.2	GAS5 H19 MALAT1 MEG3
29	oral squamous cell carcinoma	10.2	H19 MALAT1 MEG3
30	gallbladder cancer	10.2	CDKN2B-AS1 H19 MALAT1 MEG3
31	wilms tumor 1	10.2	AR H19 IGF2-AS MEG3
32	coronary heart disease 1	10.2	CDKN2B-AS1 GAS5 H19 IGF2-AS
33	myeloma, multiple	10.1	GAS5 H19 MALAT1 MEG3 PCAT1
34	lung cancer susceptibility 3	10.1	GAS5 H19 MALAT1 MEG3
35	squamous cell carcinoma	10.1	CBR3-AS1 CDKN2B-AS1 H19 MALAT1 PCAT1
36	nasopharyngeal carcinoma	10.1	CDKN2B-AS1 GAS5 H19 MALAT1 MEG3
37	renal cell carcinoma, nonpapillary	10.1	GAS5 H19 LINC00963 MALAT1 PTENP1
38	cystitis cystica	10.1	AR KLK3
39	melanoma	10.1	CDKN2B-AS1 GAS5 H19 MALAT1 MEG3
40	endometrial cancer	10.1	AR GAS5 H19 MEG3 PTENP1
41	osteogenic sarcoma	10.1	CDKN2B-AS1 GAS5 H19 MALAT1 MEG3 PCAT1
42	glioma	10.1	CBR3-AS1 CDKN2B-AS1 GAS5 H19 MALAT1 MEG3
43	esophageal cancer	10.1	CDKN2B-AS1 GAS5 H19 MALAT1 MEG3 PCAT1
44	glioblastoma	10.1	GAS5 H19 LINC00963 MALAT1 MEG3 PCAT1
45	bladder cancer	10.0	CDKN2B-AS1 GAS5 H19 MALAT1 MEG3 PCAT1
46	cervical cancer	10.0	CDKN2B-AS1 GAS5 H19 MALAT1 MEG3 PCAT1
47	pancreatic cancer	10.0	CDKN2B-AS1 GAS5 H19 MALAT1 MEG3
48	adamantinoma of long bones	10.0	CDKN2B-AS1 GAS5 H19 KLK3 MALAT1 MEG3
49	lung cancer	9.9	CDKN2B-AS1 GAS5 H19 IGF2-AS MALAT1 MEG3
50	gastric cancer	9.9	CBR3-AS1 CDKN2B-AS1 GAS5 H19 MALAT1 MEG3

Comorbidity relations with Prostate Disease via Phenotypic Disease Network (PDN):

Prostate Cancer

Prostatic Hypertrophy

Graphical network of the top 20 diseases related to Prostate Disease:

Sources

Symptoms & Phenotypes for Prostate Disease

UMLS symptoms related to Prostate Disease:

tremor, angina pectoris, equilibration disorder, prostatism

Sources

Drugs & Therapeutics for Prostate Disease

Drugs for Prostate Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 847)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Iodine

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

7553-56-2

807

Povidone

Approved

Phase 4

9003-39-8

Povidone-iodine

Approved

Phase 4,Not Applicable

25655-41-8

Tamsulosin

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

106133-20-4

129211

Fentanyl

Approved, Illicit, Investigational, Vet_approved

Phase 4,Not Applicable

437-38-7

3345

Bupivacaine

Approved, Investigational

Phase 4,Phase 1,Phase 2,Not Applicable

2180-92-9, 38396-39-3

2474

Saw palmetto

Approved, Experimental, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Dutasteride

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

164656-23-9

6918296 152945

Finasteride

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

98319-26-7

57363

Ethanol

Approved

Phase 4,Phase 2,Phase 1,Not Applicable

64-17-5

702

Metformin

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

657-24-9

14219 4091

Goserelin

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

65807-02-5

47725 5311128

Doxazosin

Approved

Phase 4,Phase 3,Phase 2,Not Applicable

74191-85-8

3157

Alfuzosin

Approved, Investigational

Phase 4,Phase 3,Phase 2,Not Applicable

81403-80-7

2092

Lidocaine

Approved, Vet_approved

Phase 4,Phase 2,Not Applicable

137-58-6

3676

Testosterone

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable

58-22-0

6013

Tadalafil

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

171596-29-5

110635

Testosterone enanthate

Approved

Phase 4,Phase 2,Phase 1,Not Applicable

315-37-7

9416

Methyltestosterone

Approved

Phase 4,Phase 2,Phase 1,Not Applicable

58-18-4

6010

Testosterone undecanoate

Approved, Investigational

Phase 4,Phase 2,Phase 1,Not Applicable

5949-44-0

Histamine

Approved, Investigational

Phase 4,Phase 2,Early Phase 1

51-45-6, 75614-87-8

774

Lenograstim

Approved, Investigational

Phase 4,Phase 2,Phase 3,Phase 1

135968-09-1

Methylprednisolone

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1

83-43-2

6741

Methylprednisolone hemisuccinate

Approved

Phase 4,Phase 3,Phase 2,Phase 1

2921-57-5

Prednisolone

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1

50-24-8

5755

Prednisolone phosphate

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1

302-25-0

Docetaxel

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

114977-28-5

148124

Prednisone

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

53-03-2

5865

Leuprolide

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

53714-56-0

657181 3911

Bicalutamide

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

90357-06-5

2375 56069

Acetaminophen

Approved

Phase 4,Phase 2,Phase 1

103-90-2

1983

Benzocaine

Approved, Investigational

Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable

94-09-7, 1994-09-7

2337

tannic acid

Approved

Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable

Pasireotide

Approved

Phase 4,Phase 1,Phase 2

396091-73-9

9941444

Somatostatin

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1

51110-01-1, 38916-34-6

53481605

Flutamide

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

13311-84-7

3397

Denosumab

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

615258-40-7

Celecoxib

Approved, Investigational

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

169590-42-5

2662

Ciprofloxacin

Approved, Investigational

Phase 4,Phase 3,Phase 2,Not Applicable

85721-33-1

2764

Terazosin

Approved

Phase 4,Not Applicable

63590-64-7

5401

Ertapenem

Approved, Investigational

Phase 4

153832-46-3

150610

Silodosin

Approved

Phase 4,Phase 3,Phase 2

160970-54-7

Levobupivacaine

Approved, Investigational

Phase 4

27262-47-1

92253

Dihydrotachysterol

Approved

Phase 4,Phase 2

67-96-9

5281010 5311071

Fesoterodine

Approved

Phase 4

286930-03-8, 286930-02-7

6918558

Mepivacaine

Approved, Vet_approved

Phase 4

96-88-8

4062

Ketamine

Approved, Vet_approved

Phase 4

6740-88-1

3821

Midazolam

Approved, Illicit

Phase 4,Phase 1,Not Applicable

59467-70-8

4192

Granisetron

Approved, Investigational

Phase 4

109889-09-0

3510

Promethazine

Approved, Investigational

Phase 4,Phase 2,Phase 1

60-87-7

4927

Interventional clinical trials:

(show top 50) (show all 4127)

#	Name	Status	NCT ID	Phase	Drugs
1	A Prospective Trial of Povidone-iodine Suppository Before Transrectal Ultrasound Guided Prostate Biopsy	Unknown status	NCT02245334	Phase 4	Povidone-Iodine
2	Efficacy and Safety of Naftopidil in Patient With Neurogenic Lower Urinary Tract Dysfunction Not Caused by Benign Prostatic Hyperplasia	Unknown status	NCT02034604	Phase 4	Naftofidil;Tamsulosin
3	Ejaculatory Sparing vs. Non-ejaculatory Sparing GreenLight Laser Photoselective Vaporization of the Prostate	Unknown status	NCT02749604	Phase 4
4	Post-Marketing Study Using PROLIEVE® for the Treatment of Benign Prostatic Hyperplasia (BPH)	Unknown status	NCT02021032	Phase 4
5	Low Dose Bupivacaine Spinal for Trans Uretral Prostatectomy.	Unknown status	NCT01861041	Phase 4	Heavy Bupivacaine;Isobaric Bupivacaine
6	Comparison Between Alpha Blocker Monotherapy and 5ARI Monotherapy Following Combination Therapy in Benign Prostatic Hyperplasia (BPH)	Unknown status	NCT01301599	Phase 4	combination therapy;alpha blocker monotherapy;5 alpha reductase inhibitor monotherapy
7	A Study Comparing Photoselective Vaporization of the Prostate With the GreenLight XPS™ Laser System and Transurethral Resection of the Prostate for the Treatment of Benign Prostatic Hyperplasia	Unknown status	NCT01218672	Phase 4
8	Clinical Study to Assess the Influence of a Saw Palmetto Preparation in Patients With Benign Prostatic Hyperplasia (BPH) and Sexual Dysfunctions	Unknown status	NCT01021267	Phase 4	Saw palmetto berry extract
9	A Study to Determine the Improvement of the Symptoms of Benign Prostatic Hyperplasia (BPH) When Switching Subjects From Proscar to Avodart	Unknown status	NCT00690950	Phase 4	Dutasteride
10	Kinetics of the Finasteride Prostate Induced Apoptosis	Unknown status	NCT00130767	Phase 4	finasteride
11	Prostatic Artery Embolization Versus 532 nm Green Light PVP for Catheterized Patients	Unknown status	NCT02006303	Phase 4
12	Advanced Benefits of Alpha-blocker Monotherapy on Lower Urinary Tracts Symptoms(LUTS) Patients	Unknown status	NCT01736033	Phase 4	Tamsulosin;Finasteride;Placebo
13	Metformin And Longevity	Unknown status	NCT02511665	Phase 4	Metformin;Placebo
14	Comparison of Between ThinSeed™ and OncoSeed™ for Permanent Prostate Brachytherapy	Unknown status	NCT01379742	Phase 4
15	Treatment of Localized Prostate Cancer With High Intensity Focused Ultrasound Using the Sonablate® 500 System in Canada	Unknown status	NCT00573586	Phase 4
16	FINNPROSTATE Study VII: Intermittent Versus Continuous Androgen Deprivation in Patients With Advanced Prostate Cancer	Unknown status	NCT00293670	Phase 4	Goserelin (Zoladex)
17	Trial of HoLEP vs. PVP in Treating BPH in Patients With Bleeding Tendency	Unknown status	NCT02293759	Phase 4
18	Clasic Laryngeal Mask Airway(C-LMA) and I-gel Releated Regurgitation and Complications	Unknown status	NCT01876836	Phase 4
19	Can Hyperbaric Oxygen Improve Erectile Function Following Surgery for Prostate Cancer	Unknown status	NCT00906269	Phase 4	Sildenafil therapy plus post-NSRRP HBO2T;Sildenafil therapy plus sham post-NSRRP HBO2T
20	Combination Treatment With Doxazosin Plus TolterodineSR 2 mg Versus 4mg in Men With an Overactive Bladder (OAB) and Benign Prostatic Hyperplasia (BPH)	Unknown status	NCT00922506	Phase 4	doxazosin plus tolterodine SR
21	MR-Lymphography and Lymph Node Staging in Prostate Cancer	Unknown status	NCT00185029	Phase 4
22	Alfuzosin XL Lower Urinary Tract Symptoms Efficacy and Sexuality Study	Completed	NCT00575913	Phase 4	Alfuzosin
23	Treatment of Chronic Bacterial Prostatitis	Completed	NCT02130713	Phase 4	Third generation fluoroquinolone
24	Evaluation Of The Efficacy And Safety Of The Doxasozin Gastrointestinal Therapeutic System (GITS) In Patients With Prostate Enlargement	Completed	NCT00648323	Phase 4	Doxazosin mysylate GITS
25	Benign Prostatic Hyperplasia (BPH) Screening Tool Case Finding Study in Subjects >=50 Years	Completed	NCT02757963	Phase 4
26	A Trial Assessing Peri-procedure Chemoprophylaxis During Transrectal Prostate Needle Biopsy	Completed	NCT02423759	Phase 4	ciprofloxacin;ciprofloxacin and gentamycine;culture based chemoprophylaxis
27	FLOMAX® Versus HYTRIN® in Patients With the Signs and Symptoms of Benign Prostatic Hyperplasia	Completed	NCT02244255	Phase 4	FLOMAX® capsules;Ascending doses of HYTRIN® capsules
28	Study to Evaluate the Symptomatic Relief Effects of FLOMAX® in Patients With Signs and Symptoms of Benign Prostatic Hyperplasia	Completed	NCT02244242	Phase 4	Tamsulosin hydrochloride
29	Study to Evaluate the Therapeutic Action of Tamsulosin and Finasteride in Symptomatic Benign Prostatic Hyperplasia (BPH) Patients	Completed	NCT02244229	Phase 4	Tamsulosin;Finasteride;Placebo
30	KTP Green Light Prostatectomy Compared With Open Prostatectomy	Completed	NCT02072499	Phase 4
31	Assessment of Prostatic Tissue Concentration of Ertapenem After a Pre-operative Administration	Completed	NCT02041767	Phase 4	Ertapenem
32	Prospective Sexual Function Study for BPH Subjects	Completed	NCT01777269	Phase 4	Dutasteride plus tamsulosin;Placebo
33	Effectiveness and Safety of Silodosin in the Treatment of Benign Prostatic Hyperplasia	Completed	NCT01757769	Phase 4	Silodosin
34	Addition of Lidocaine to Levobupivacaine Reduces Intrathecal Block Duration	Completed	NCT01675895	Phase 4	Levobupivacaine lidocaine spinal anesthesia;levobupivacaine Spinal anesthesia
35	Exploratory Study of L.S.E.S.r. (LipidoSterolic Extract of Serenoa Repens)(PERMIXON® 160 mg Hard Capsule) Versus Tamsulosine LP Activity on Inflammation Biomarkers in Urinary Symptoms Related to BPH (Benign Prostatic Hyperplasia)	Completed	NCT01604811	Phase 4	Permixon® 160 mg;Tamsulosine Arrow LP;Placebo matching Permixon® 160 mg;Placebo matching Tamsulosine Arrow LP
36	Phase 4 Study of Greenlight XPS Laser Versus BiVAP Saline Vaporization of the Prostate in Men With Symptomatic Benign Prostatic Hyperplasia	Completed	NCT01500057	Phase 4
37	Holmium Laser Enucleation of Prostate(HOLEP) vs Greenlight(XPS) Laser Photoselective Vapo-Enucleation of Prostate(PVEP)	Completed	NCT01494337	Phase 4
38	Comparative Efficacy of Dutasteride Plus Tamulosin With Lifestyle Advice Versus Watchful Waiting Plus Lifestyle Advice in the Management of Treatment naïve Men With Moderately Symptomatic Benign Prostatic Hyperplasia and Prostate Enlargement	Completed	NCT01294592	Phase 4	Dutasteride plus tamsulosin;tamsulosin
39	Study of a α1A Adrenoceptor Selective Antagonist Silodosin to Treat Severe Benign Prostatic Hyperplasia(BPH)	Completed	NCT01259531	Phase 4	Silodosin
40	Effect of Dutasteride on HIF-1alpha and VEGF in the Prostate	Completed	NCT00880672	Phase 4	dutasteride
41	Dutasteride and Flex Dose of Tamsulosin on as Needed Basis, to Treat Benign Prostatic Hyperplasia	Completed	NCT00701779	Phase 4	Tamsulosin
42	Once Daily Given Alfuzosin in the Treatment of BPH	Completed	NCT00637715	Phase 4	Alfuzosin
43	SAMBA: Sexuality And Management of Benign Prostatic Hyperplasia With Alfuzosin	Completed	NCT00486785	Phase 4	Alfuzosin
44	A Long-Term Study Examining the Treatment of Benign Prostatic Hyperplasia With Photoselective Vaporization	Completed	NCT00465101	Phase 4
45	Male Sexual Health Questionnaire (MSHQ) - Sexual Function Study	Completed	NCT00427882	Phase 4	ALFUZOSIN
46	Sexuality And Management of Benign Prostatic Hyperplasia With Alfuzosin	Completed	NCT00401661	Phase 4	Alfuzosin
47	A Prospective Evaluation of the GreenLight Model 120 Laser	Completed	NCT00364585	Phase 4
48	ALF-ONE : ALFuzosin ONcE Daily	Completed	NCT00280605	Phase 4	Alfuzosin
49	Bipolar vs Monopolar Transurethral Resection of the Prostate (TURP)	Completed	NCT00199550	Phase 4
50	Effect Of Dutasteride On Intraprostatic Dihydrotestosterone (DHT) Levels	Completed	NCT00062790	Phase 4	Dutasteride

Search NIH Clinical Center for Prostate Disease

Inferred drug relations via UMLS ⁷³ / NDF-RT ⁵¹ :

mannitol hexanitrate

Cochrane evidence based reviews: prostatic diseases

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Genetic Tests for Prostate Disease

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Anatomical Context for Prostate Disease

MalaCards organs/tissues related to Prostate Disease:

⁴¹

Prostate, Kidney, Testes, Endothelial, Heart, Ovary, Pancreas

Sources

Publications for Prostate Disease

Articles related to Prostate Disease:

(show top 50) (show all 230)

#	Title	Authors	Year
1	Setting up a service for men with benign prostate disease. ( 29561636 )	Firoz A.	2018
2	Canine Prostate Disease. ( 29933768 )	Christensen B.W.	2018
3	Association between male pattern baldness and prostate disease: A meta-analysis. ( 29054497 )		2018
4	Targeting PSMA by radioligands in non-prostate disease-current status and future perspectives. ( 29335762 )		2018
5	Prostate cancer and prostatic diseases Best of China, 2018. ( 30518869 )	Ye DW...Zhu Y	2018
6	20 years-A retrospective of prostate cancer and prostatic diseases. ( 29259294 )	Freedland SJ	2018
7	CPSE determination and detection of canine prostatic diseases: The importance of a specific diagnosis. ( 29956380 )	Martins-Bessa A	2018
8	Re: Evolution of Primary Care Referrals to Urology. Impact of a Protocol on Prostate Disease and Continuing Education. ( 29144897 )	Kaplan S.A.	2017
9	Dynamic instrumented palpation - a new method for soft tissue quality assessment: application to prostate disease diagnosis. ( 28965477 )	Yang T.J....McNeill S.A.	2017
10	Over-Expression of Activin-I^C Is Associated with Murine and Human Prostate Disease. ( 28116672 )		2017
11	Fatigue, depression, and quality of life in patients with prostatic diseases. ( 28461987 )	Engl T...Grabhorn R	2017
12	Simultaneous Detection of Oral Pathogens in Subgingival Plaque and Prostatic Fluid of Men With Periodontal and Prostatic Diseases. ( 28548883 )	Estemalik J...Gupta S	2017
13	Association between age-related reductions in testosterone and risk of prostate cancer-An analysis of patients' data with prostatic diseases. ( 28699177 )	Wang K...Prosperi M	2017
14	Knowledge, attitudes and screening practices regarding prostatic diseases among men older than 40 years: a population-based study in Southwest Nigeria. ( 28904679 )	Ojewola RW...Oluyombo R	2017
15	Oxidative stress and prostatic diseases. ( 29181163 )	Roumegu?re T...Aoun F	2017
16	Erratum: Comparative study of serum zinc concentrations in benign and malignant prostate disease: A Systematic Review and Meta-Analysis. ( 27436144 )		2016
17	Comparative study of serum zinc concentrations in benign and malignant prostate disease: A Systematic Review and Meta-Analysis. ( 27170414 )		2016
18	Re: Testosterone Replacement Therapy on the Natural History of Prostate Disease. ( 27845125 )		2016
19	A retrospective study of canine prostatic diseases from 2002 to 2009 at the Alfort Veterinary College in France. ( 26613854 )	Polisca A...Fontbonne A	2016
20	Prostatectomy for benign prostate disease: open, laparoscopic and robotic techniques. ( 26497345 )	Ferretti M....Phillips J.	2015
21	Initial Evaluation of the Safety of Nanoshell-Directed Photothermal Therapy in the Treatment of Prostate Disease. ( 26296672 )	Stern J.M....Goodrich G.P.	2015
22	Testosterone Replacement Therapy on the Natural History of Prostate Disease. ( 26077355 )	Moore A....KAPhler T.S.	2015
23	Configuration and validation of a novel prostate disease nomogram predicting prostate biopsy outcome: A prospective study correlating clinical indicators among Filipino adult males with elevated PSA level. ( 29264129 )	Chua M.E....Luna S.L.	2015
24	Further evaluation of uPA and PAI-1 as biomarkers for prostatic diseases. ( 25323935 )		2015
25	Serum GADD45a methylation is a useful biomarker to distinguish benign vs malignant prostate disease. ( 26171936 )		2015
26	Prostatic diseases under focus in a university hospital in Eastern Saudi Arabia. A 15-year experience. ( 26593165 )	Al Nemer AM...Aldamanhori RB	2015
27	MALDI MS profiling of post-DRE urine samples highlights the potential of I^-microseminoprotein as a marker for prostatic diseases. ( 24115268 )	Flatley B....Cramer R.	2014
28	Lycopene for the prevention and treatment of prostate disease. ( 24531784 )	Ilic D.	2014
29	Evolution of primary care referrals to urology. Impact of a protocol on prostate disease and continuing education. ( 25554605 )		2014
30	Nonsteroidal anti-inflammatory drugs and prostatic diseases. ( 24900965 )	Ishiguro H...Kawahara T	2014
31	New and experimental techniques in the treatment of benign prostatic diseases. ( 25782231 )	Pej?i? T...Had?i-Djoki? J	2014
32	Androgens and prostate disease. ( 24407178 )	Cooper L.A....Page S.T.	2013
33	Circulating Prostate Cells Found in Men with Benign Prostate Disease Are P504S Negative: Clinical Implications. ( 23690774 )		2013
34	Effect of microbubble-enhanced ultrasound on prostate permeability: a potential therapeutic method for prostate disease. ( 23414693 )		2013
35	Current status of 5I+-reductase inhibitors in prostate disease management. ( 23614056 )		2013
36	Recent advances in prostate development and links to prostatic diseases. ( 23335485 )	Powers GL...Marker PC	2013
37	Re: Involvement of estrogen receptors in prostatic diseases. ( 23663624 )	Kaplan SA	2013
38	Steroidal 5α-reductase and 17α-hydroxylase/17,20-lyase (CYP17) inhibitors useful in the treatment of prostatic diseases. ( 23688836 )	Salvador JA...Silvestre SM	2013
39	Clinico-pathological Correlation of Digital Rectal Examination Findings Amongst Nigerian Men with Prostatic Diseases: A Prospective Study of 236 Cases. ( 24027415 )	Ojewola RW...Anunobi CC	2013
40	Hospitalization decreases serum prostate-specific antigen values compared with outpatient values in patients with benign prostatic diseases. ( 24044092 )	Yoon IS...Kim SJ	2013
41	Treatment for prostate disease should be uniform across the UK. ( 27794764 )	Davies K.	2012
42	Patient reported incontinence after radical prostatectomy is more common than expected and not associated with the nerve sparing technique: results from the Center for Prostate Disease Research (CPDR) database. ( 21826727 )	Peterson A.C....Chen Y.	2012
43	Can a Gleason 6 or Less Microfocus of Prostate Cancer in One Biopsy and Prostate-Specific Antigen Level &lt;10a88ng/mL Be Defined as the Archetype of Low-Risk Prostate Disease? ( 22848218 )	Taverna G....Graziotti P.	2012
44	Prostate disease risk factors among a New Zealand cohort. ( 23363810 )	Karunasinghe N....Ferguson L.R.	2012
45	Botulinum toxin A in prostate disease: a venom from bench to bed-side. ( 22409179 )	Mearini L....Giannantoni A.	2012
46	Aromatase up-regulation, insulin and raised intracellular oestrogens in men, induce adiposity, metabolic syndrome and prostate disease, via aberrant ER-I+ and GPER signalling. ( 22233684 )		2012
47	Role of 5α-reductase inhibitors in benign prostatic diseases. ( 22333687 )	Azzouni F...Mohler J	2012
48	Involvement of estrogen receptors in prostatic diseases. ( 22375605 )	Kawashima H...Nakatani T	2012
49	Editorial comment to involvement of estrogen receptors in prostatic diseases. ( 22621219 )	Takahashi S	2012
50	Steroid hormone receptors, matrix metalloproteinases, insulin-like growth factor, and dystroglycans interactions in prostatic diseases in the elderly men. ( 22648746 )	Hetzl AC...Cagnon VH	2012

Sources

Genes for Prostate Disease

Genes related to Prostate Disease (0 elite genes):

(show all 44)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	PCA3	Prostate Cancer Associated 3	RNA Gene	158.34	Experimental evidence ³⁹ DISEASES inferred ¹⁵	24667321 24373479 21883822 (more) 20980098 20424427 18602209 18054202 15245811
2	PCGEM1	PCGEM1, Prostate-Specific Transcript	RNA Gene	156	Experimental evidence: Expression ³⁹ DISEASES inferred ¹⁵	24713835 24667321 24373479 (more) 24146262 23945587 23459097 20951849
3	SCHLAP1	SWI/SNF Complex Antagonist Associated With Prostate Cancer 1	RNA Gene	155.75	Experimental evidence: Expression ³⁹ DISEASES inferred ¹⁵	24829860
4	PRNCR1	Prostate Cancer Associated Non-Coding RNA 1	RNA Gene	155.56	Experimental evidence: Expression ³⁹ DISEASES inferred ¹⁵	24713835 24373479 24146262 (more) 23945587
5	PCAT1	Prostate Cancer Associated Transcript 1	RNA Gene	155.55	Experimental evidence: Expression ³⁹ DISEASES inferred ¹⁵	24531795 24373479 24146262
6	CBR3-AS1	CBR3 Antisense RNA 1	RNA Gene	154.77	Experimental evidence: Expression ³⁹ DISEASES inferred ¹⁵	24373479
7	CTBP1-AS	CTBP1 Antisense RNA	RNA Gene	154.15	Experimental evidence: Expression ³⁹ DISEASES inferred ¹⁵	24531795 24373479
8	GAS5	Growth Arrest Specific 5	RNA Gene	153.7	Experimental evidence: Expression ³⁹ DISEASES inferred ¹⁵	24373479
9	MALAT1	Metastasis Associated Lung Adenocarcinoma Transcript 1	RNA Gene	153.51	Experimental evidence: Expression ³⁹ DISEASES inferred ¹⁵	24373479 22996375
10	CDKN2B-AS1	CDKN2B Antisense RNA 1	RNA Gene	153.11	Experimental evidence: Expression ³⁹ DISEASES inferred ¹⁵	24721780 24624135 24146262 (more) 23660942 23463798 22996375
11	TERC	Telomerase RNA Component	RNA Gene	150	Experimental evidence: Expression ³⁹	24146262
12	PTENP1	Phosphatase And Tensin Homolog Pseudogene 1	Pseudogene	150	Experimental evidence: Expression ³⁹	24373479
13	MEG3	Maternally Expressed 3	RNA Gene	150	Experimental evidence: Expression ³⁹	14602737
14	LINC00963	Long Intergenic Non-Protein Coding RNA 963	RNA Gene	150	Experimental evidence: Expression ³⁹	24691949
15	IGF2-AS	IGF2 Antisense RNA	RNA Gene	150	Experimental evidence: Mutation ³⁹	19767753
16	H19	H19, Imprinted Maternally Expressed Transcript	RNA Gene	150	Experimental evidence: Expression ³⁹	24373479
17	KLK3	Kallikrein Related Peptidase 3	Protein Coding	39.4	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	7551887 11720279 12394676 (more) 7685140 18668524 8638528 7533583 12962896 14624905 12670590 11597539 9255665 16093978 9605898 1720276 18686378 17159365 10510889 8750649 12629773 11107529 14532846 1697014 9628610 9800478 17318358 7516808 7479385 8973699 17639509 17039018 17571482 15643540 12865450 12408465 11903683 9617617 9352130 7542820 19670261 19486654 11326656 11220990 10750886 9772876 9594181 7684154 10759667 8977078 7523722 7690018 7683136 1284590 1720942 19507229 16643633 19152248 19128049 15009080 10510891 10481967 10368243 9730460 1726942 1690092 7503657 7514278 1707140 17320672 16686717 14665872 11741128 11301608 10202130 9161183 7538598 7521173 1688677 17997422 15378521 15623486 11036851 10961472 10068342 11198954 9266234 9126092 7531895 7519804 1385141 1699766 1698232 1693867 19541477 19375853 19375623 18820278 8725043 7528864
18	AR	Androgen Receptor	Protein Coding	32.41	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	12670590 17881894 18627423 (more) 18320593
19	FOLH1	Folate Hydrolase 1	Protein Coding	30.62	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	10632336
20	SERPINA3	Serpin Family A Member 3	Protein Coding	23.07	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	8977078
21	AMACR	Alpha-Methylacyl-CoA Racemase	Protein Coding	23.01	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	17639509 19157222
22	AKR1C3	Aldo-Keto Reductase Family 1 Member C3	Protein Coding	22.43	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
23	SRD5A1	Steroid 5 Alpha-Reductase 1	Protein Coding	21.47	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	17052442 8778238 18046919 (more) 19030020 7522999 18579171 15956333
24	PPARG	Peroxisome Proliferator Activated Receptor Gamma	Protein Coding	21.23	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
25	HBEGF	Heparin Binding EGF Like Growth Factor	Protein Coding	20.51	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
26	GADD45A	Growth Arrest And DNA Damage Inducible Alpha	Protein Coding	20.05	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
27	HP	Haptoglobin	Protein Coding	19.49	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
28	PSMA1	Proteasome Subunit Alpha 1	Protein Coding	19.2	DISEASES inferred ¹⁵ ¹⁵
29	CYP19A1	Cytochrome P450 Family 19 Subfamily A Member 1	Protein Coding	18.99	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	9140125 20351196
30	TMPRSS2	Transmembrane Serine Protease 2	Protein Coding	18.75	DISEASES inferred ¹⁵
31	KLK2	Kallikrein Related Peptidase 2	Protein Coding	15.61	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	15378521 9033261
32	ACPP	Acid Phosphatase, Prostate	Protein Coding	13.14	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	1721770 1693867 15623486 (more) 1280403 19128049 1688677
33	GRP	Gastrin Releasing Peptide	Protein Coding	11.79	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	12858359
34	ENPP2	Ectonucleotide Pyrophosphatase/Phosphodiesterase 2	Protein Coding	8.99	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
35	SLC30A4	Solute Carrier Family 30 Member 4	Protein Coding	8.95	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
36	PTEN	Phosphatase And Tensin Homolog	Protein Coding	7.92	DISEASES inferred ¹⁵
37	NKX3-1	NK3 Homeobox 1	Protein Coding	7.78	DISEASES inferred ¹⁵
38	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	7.75	DISEASES inferred ¹⁵
39	CYP17A1	Cytochrome P450 Family 17 Subfamily A Member 1	Protein Coding	7.69	DISEASES inferred ¹⁵
40	TP53	Tumor Protein P53	Protein Coding	7.33	DISEASES inferred ¹⁵
41	SHC4	SHC Adaptor Protein 4	Protein Coding	7.22	DISEASES inferred ¹⁵
42	PSCA	Prostate Stem Cell Antigen	Protein Coding	7.14	DISEASES inferred ¹⁵
43	MSMB	Microseminoprotein Beta	Protein Coding	7.08	DISEASES inferred ¹⁵
44	IGF1	Insulin Like Growth Factor 1	Protein Coding	7.07	DISEASES inferred ¹⁵

Sources

Variations for Prostate Disease

Sources

Expression for Prostate Disease

Search GEO for disease gene expression data for Prostate Disease.

Sources

Pathways for Prostate Disease

Sources

GO Terms for Prostate Disease

Biological processes related to Prostate Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of systemic arterial blood pressure	GO:0003073	8.62	AR KLK3

Sources

Sources for Prostate Disease

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia

Prostate Disease

Aliases & Classifications for Prostate Disease

MalaCards integrated aliases for Prostate Disease:

Classifications:

External Ids:

Summaries for Prostate Disease

Related Diseases for Prostate Disease

Diseases related to Prostate Disease via text searches within MalaCards or GeneCards Suite gene sharing:

Comorbidity relations with Prostate Disease via Phenotypic Disease Network (PDN):

Graphical network of the top 20 diseases related to Prostate Disease:

Symptoms & Phenotypes for Prostate Disease

UMLS symptoms related to Prostate Disease:

Drugs & Therapeutics for Prostate Disease

Drugs for Prostate Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 73 / NDF-RT 51 :

Cochrane evidence based reviews: prostatic diseases

Genetic Tests for Prostate Disease

Anatomical Context for Prostate Disease

MalaCards organs/tissues related to Prostate Disease:

Publications for Prostate Disease

Articles related to Prostate Disease:

Genes for Prostate Disease

Genes related to Prostate Disease (0 elite genes):

Variations for Prostate Disease

Expression for Prostate Disease

Pathways for Prostate Disease

GO Terms for Prostate Disease

Biological processes related to Prostate Disease according to GeneCards Suite gene sharing:

Sources for Prostate Disease

Inferred drug relations via UMLS ⁷³ / NDF-RT ⁵¹ :