MCID: PRS010
MIFTS: 26

Prostate Embryonal Rhabdomyosarcoma

Categories: Cancer diseases, Fetal diseases, Reproductive diseases

Aliases & Classifications for Prostate Embryonal Rhabdomyosarcoma

MalaCards integrated aliases for Prostate Embryonal Rhabdomyosarcoma:

Name: Prostate Embryonal Rhabdomyosarcoma 12 15 70
Embryonal Rhabdomyosarcoma of the Prostate 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3251
NCIt 50 C5525
UMLS 70 C1335508

Summaries for Prostate Embryonal Rhabdomyosarcoma

Disease Ontology : 12 A prostate rhabdomyosarcoma that is most common in children and that is characterized by a high degree of malignancy, both local rapid growth with formation of large pelvic masses, often leading to renal failure due to urethral obstruction, and systemic spread, commonly to the lungs, liver and bone.

MalaCards based summary : Prostate Embryonal Rhabdomyosarcoma, also known as embryonal rhabdomyosarcoma of the prostate, is related to prostate rhabdomyosarcoma and embryonal rhabdomyosarcoma. An important gene associated with Prostate Embryonal Rhabdomyosarcoma is CALD1 (Caldesmon 1), and among its related pathways/superpathways are Cell adhesion_ECM remodeling and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include prostate, and related phenotype is muscle.

Related Diseases for Prostate Embryonal Rhabdomyosarcoma

Diseases related to Prostate Embryonal Rhabdomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)
# Related Disease Score Top Affiliating Genes
1 prostate rhabdomyosarcoma 31.2 MYOG MYOD1
2 embryonal rhabdomyosarcoma 30.5 MYOG MYOD1
3 rhabdomyosarcoma 28.9 TOP1 MYOG MYOD1 KIT IGF1R
4 lung combined type small cell carcinoma 10.2 MYOG CALD1
5 cervical polyp 10.2 MYOG CALD1
6 pulmonary vein leiomyosarcoma 10.1 MYOD1 CALD1
7 sudden infant death syndrome 10.1
8 rare soft tissue tumor 10.1
9 prostate sarcoma 10.1 MYOG KLK3
10 malignant fibrous histiocytoma of bone 10.1 MYOD1 CALD1
11 urethral benign neoplasm 10.1 KLK3 CALD1
12 skeletal muscle neoplasm 10.1 MYOG MYOD1
13 undifferentiated embryonal sarcoma of the liver 10.1 MYOG MYOD1
14 gallbladder sarcoma 10.1 MYOG MYOD1
15 malignant fibrous histiocytoma 10.1 MYOG MYOD1
16 central nervous system mesenchymal non-meningothelial tumor 10.1 MYOG MYOD1
17 malignant triton tumor 10.1 MYOG MYOD1
18 urethra leiomyoma 10.1 KIT CALD1
19 botryoid rhabdomyosarcoma 10.1 MYOG MYOD1
20 gallbladder leiomyosarcoma 10.1 KIT CALD1
21 deep leiomyoma 10.1 KIT CALD1
22 angiomyoma 10.1 KIT CALD1
23 breast leiomyosarcoma 10.1 KIT CALD1
24 gastric leiomyoma 10.1 KIT CALD1
25 extraosseous ewing sarcoma 10.1 MYOG MYOD1
26 colon leiomyosarcoma 10.1 KIT CALD1
27 benign perivascular tumor 10.1 KIT CALD1
28 perivascular tumor 10.1 KIT CALD1
29 askin's tumor 10.1 MYOG IGF1R
30 small intestine leiomyoma 10.1 KIT CALD1
31 breast rhabdomyosarcoma 10.1 MYOG MYOD1
32 prostate disease 10.0
33 retroperitoneal leiomyosarcoma 10.0 KIT CALD1
34 spindle cell rhabdomyosarcoma 10.0 MYOG MYOD1
35 skin sarcoma 10.0 KIT CALD1
36 sarcomatous intrahepatic cholangiocarcinoma 10.0 KIT CALD1
37 glomangiomatosis 10.0 KIT CALD1
38 small cell carcinoma 10.0 KLK3 KIT
39 liver leiomyosarcoma 10.0 KIT CALD1
40 heart sarcoma 10.0 MYOG KIT
41 esophagus sarcoma 10.0 KIT CALD1
42 small intestinal sarcoma 10.0 KLK3 KIT
43 gas gangrene 10.0 MYOG MYOD1
44 pleomorphic rhabdomyosarcoma 10.0 MYOG MYOD1
45 mesenchymal chondrosarcoma 10.0 MYOG MYOD1
46 heart cancer 10.0 MYOG KIT
47 retroperitoneum carcinoma 10.0 KIT CALD1
48 pleomorphic liposarcoma 10.0 KIT CALD1
49 perivascular epithelioid cell tumor 10.0 KIT CALD1
50 seminal vesicle adenocarcinoma 10.0 KLK3 KIT

Graphical network of the top 20 diseases related to Prostate Embryonal Rhabdomyosarcoma:



Diseases related to Prostate Embryonal Rhabdomyosarcoma

Symptoms & Phenotypes for Prostate Embryonal Rhabdomyosarcoma

MGI Mouse Phenotypes related to Prostate Embryonal Rhabdomyosarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.02 IGF1R KIT KLK3 MYOD1 MYOG

Drugs & Therapeutics for Prostate Embryonal Rhabdomyosarcoma

Search Clinical Trials , NIH Clinical Center for Prostate Embryonal Rhabdomyosarcoma

Genetic Tests for Prostate Embryonal Rhabdomyosarcoma

Anatomical Context for Prostate Embryonal Rhabdomyosarcoma

MalaCards organs/tissues related to Prostate Embryonal Rhabdomyosarcoma:

40
Prostate

Publications for Prostate Embryonal Rhabdomyosarcoma

Articles related to Prostate Embryonal Rhabdomyosarcoma:

(show all 30)
# Title Authors PMID Year
1
Neurofibromatosis-1 and Rhabdomyosarcoma: An Unusual Recurrence. 61
31794814 2020
2
A Case of Adult Metastatic Rhabdomyosarcoma of the Prostate Cured by Long-Term Chemotherapy with Local Radiation. 61
28427078 2019
3
Spindle cell embryonal rhabdomyosarcoma of the prostate in an adult patient - case report and review of clinicopathological features. 61
27357857 2016
4
A case of primary spindle cell variant of embryonal rhabdomyosarcoma of the prostate. 61
25197394 2014
5
Prostate embryonal rhabdomyosarcoma in adults: Case report and review of literature. 61
24416569 2013
6
Primary embryonal rhabdomyosarcoma of the prostate in adults: report of a case and review of the literature. 61
21427103 2011
7
Embryonal rhabdomyosarcoma of the prostate. 61
20087615 2010
8
Primary embryonal rhabdomyosarcoma of the prostate in an adult. 61
20135959 2010
9
Chemotherapy as monotherapy for treatment of non-metastatic bladder/prostate embryonal rhabdomyosarcoma in children: preliminary report. 61
18947590 2006
10
Primary embryonal rhabdomyosarcoma of prostate in adults: diagnosis and management. 61
14577499 2002
11
[Embryonal rhabdomyosarcoma of the prostate. Report of a case and review of the literature]. 61
11345801 2001
12
Chromosome abnormalities in a primary adult embryonal rhabdomyosarcoma of the prostate. 61
11184186 2000
13
Embryonal rhabdomyosarcoma of prostate in an adult--a diagnostic dilemma. 61
11261237 2000
14
Subsequent urethral relapses with extension into the corpora cavernosa of embryonal rhabdomyosarcoma of the prostate. 61
10332469 1999
15
[Prostatic rhabdomyosarcoma in adults]. 61
9887561 1998
16
[Rhabdomyosarcoma of the prostate in childhood: a case report]. 61
9783202 1998
17
Embryonal rhabdomyosarcoma of the prostate. 61
8571909 1996
18
[Prostate-bladder rhabdomyosarcoma: therapeutic approaches]. 61
7864680 1994
19
Incidental embryonal rhabdomyosarcoma of the prostate gland in sudden infant death syndrome. 61
8166121 1994
20
Prostatic embryonal rhabdomyosarcoma in adults. A clinicopathologic review. 61
1730126 1992
21
Three pediatric patients with extension of prostatic embryonal rhabdomyosarcoma anterior to the bladder into the space of Retzius. 61
1508589 1992
22
[Primary embryonic rhabdomyosarcoma of the prostate. An unusual location]. 61
2817990 1989
23
Fine-needle aspiration cytology of prostatic embryonal rhabdomyosarcoma: a case report. 61
3595414 1987
24
[Rhabdomyosarcoma of the prostate in a child: report of a case]. 61
2444085 1987
25
Radiologic aspects of embryonal rhabdomyosarcoma of the prostate in a child. 61
3900033 1985
26
Eleven-year survival following cystoprostatectomy for embryonal rhabdomyosarcoma of the prostate. 61
7087039 1982
27
Five-year survival following cystoprostatectomy for embryonal rhabdomyosarcoma of the prostate. 61
7426999 1980
28
Embryonal rhabdomyosarcoma of the prostate. 61
830977 1977
29
Embryonal rhabdomyosarcoma of the prostate. An ultrastructural study. 61
4687886 1973
30
Myosarcomas of the bladder and prostate. 61
5212307 1968

Variations for Prostate Embryonal Rhabdomyosarcoma

Expression for Prostate Embryonal Rhabdomyosarcoma

Search GEO for disease gene expression data for Prostate Embryonal Rhabdomyosarcoma.

Pathways for Prostate Embryonal Rhabdomyosarcoma

Pathways related to Prostate Embryonal Rhabdomyosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.94 KLK3 IGF1R
2 10.78 MYOG MYOD1 KIT
3
Show member pathways
10.72 MYOG MYOD1

GO Terms for Prostate Embryonal Rhabdomyosarcoma

Cellular components related to Prostate Embryonal Rhabdomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 myofibril GO:0030016 8.96 MYOD1 CALD1
2 protein-DNA complex GO:0032993 8.62 TOP1 MYOG

Biological processes related to Prostate Embryonal Rhabdomyosarcoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.81 MYOG MYOD1 KIT IGF1R
2 positive regulation of kinase activity GO:0033674 9.52 KIT IGF1R
3 skeletal muscle tissue development GO:0007519 9.49 MYOG MYOD1
4 skeletal muscle cell differentiation GO:0035914 9.48 MYOG MYOD1
5 cellular response to estradiol stimulus GO:0071392 9.46 MYOG MYOD1
6 positive regulation of muscle cell differentiation GO:0051149 9.43 MYOG MYOD1
7 skeletal muscle fiber development GO:0048741 9.4 MYOG MYOD1
8 skeletal muscle tissue regeneration GO:0043403 9.37 MYOG MYOD1
9 positive regulation of myoblast differentiation GO:0045663 9.32 MYOG MYOD1
10 myoblast differentiation GO:0045445 9.26 MYOG MYOD1
11 myotube differentiation GO:0014902 9.16 MYOG MYOD1
12 positive regulation of skeletal muscle fiber development GO:0048743 8.96 MYOG MYOD1
13 muscle cell fate commitment GO:0042693 8.62 MYOG MYOD1

Molecular functions related to Prostate Embryonal Rhabdomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proximal promoter sequence-specific DNA binding GO:0000987 9.26 MYOG MYOD1
2 chromatin DNA binding GO:0031490 9.16 MYOG MYOD1
3 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.96 KIT IGF1R
4 E-box binding GO:0070888 8.62 MYOG MYOD1

Sources for Prostate Embryonal Rhabdomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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