MCID: PRS017
MIFTS: 27

Prostate Neuroendocrine Neoplasm

Categories: Cancer diseases, Neuronal diseases, Reproductive diseases
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Aliases & Classifications for Prostate Neuroendocrine Neoplasm

MalaCards integrated aliases for Prostate Neuroendocrine Neoplasm:

Name: Prostate Neuroendocrine Neoplasm 11 14 71
Neuroendocrine Tumor of the Prostate 11

Classifications:



External Ids:

Disease Ontology 11 DOID:2992
NCIt 49 C5545
UMLS 71 C1335515

Summaries for Prostate Neuroendocrine Neoplasm

MalaCards based summary: Prostate Neuroendocrine Neoplasm, also known as neuroendocrine tumor of the prostate, is related to neuroendocrine tumor and neuroendocrine carcinoma. An important gene associated with Prostate Neuroendocrine Neoplasm is REST (RE1 Silencing Transcription Factor), and among its related pathways/superpathways are Neuroscience and GDNF signaling. The drugs Cisplatin and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include prostate, and related phenotypes are Decreased viability in pancreas lineage and nervous system

Related Diseases for Prostate Neuroendocrine Neoplasm

Diseases related to Prostate Neuroendocrine Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 358)
# Related Disease Score Top Affiliating Genes
1 neuroendocrine tumor 30.3 SYP NCAM1 KRT20 ENO2 CHGA
2 neuroendocrine carcinoma 29.1 SYP PTPRC NCAM1 KRT7 KRT20 ENO2
3 suppression of tumorigenicity 12 28.5 TMPRSS2 SYP MYCN KLK3 FOLH1 ENO2
4 prostate cancer 10.4
5 sclerosing hemangioma 10.3 SYP CHGA
6 eyelid benign neoplasm 10.3 KRT20 CHGA
7 mixed ductal-endocrine carcinoma 10.3 SYP CHGA
8 vulvar eccrine porocarcinoma 10.3 SYP CHGA
9 cervical large cell neuroendocrine carcinoma 10.3 SYP CHGA
10 duodenal benign neoplasm 10.3 SYP CHGA
11 acinar cell cystadenocarcinoma 10.3 SYP CHGA
12 mucinous cystadenofibroma 10.3 SYP KRT7
13 gastric gastrinoma 10.3 SYP CHGA
14 malignant melanocytic neoplasm of the peripheral nerve sheath 10.3 SYP ENO2
15 ectopic cushing syndrome 10.3 SYP CHGA
16 bile duct signet ring cell carcinoma 10.3 KRT7 KRT20
17 binswanger's disease 10.3 SYP CHGA
18 neuronal intestinal dysplasia, type b 10.3 SYP ENO2
19 benign perivascular tumor 10.3 SYP CHGA
20 optic nerve astrocytoma 10.3 SYP ENO2
21 urethral villous adenoma 10.3 KRT7 KRT20
22 duodenal gastrinoma 10.3 SYP CHGA
23 cloacogenic carcinoma 10.3 SYP ENO2
24 pineal region teratoma 10.3 SYP ENO2
25 vaginal glandular tumor 10.3 ENO2 CHGA
26 nephrogenic adenoma of urinary bladder 10.3 KRT7 KRT20
27 pancreatic serous cystadenocarcinoma 10.3 KRT7 KRT20
28 ovary neuroendocrine neoplasm 10.3 SYP KRT7
29 atrophic vulva 10.3 KRT7 KRT20
30 bile duct mucinous adenocarcinoma 10.3 SYP ENO2
31 mucinous bronchioloalveolar adenocarcinoma 10.3 KRT7 KRT20
32 glomangioma 10.3 SYP CHGA
33 bladder benign neoplasm 10.3 KRT7 KRT20
34 extra-adrenal pheochromocytoma 10.3 SYP CHGA
35 partial cryptophthalmia 10.3 SYP ENO2
36 intracranial primitive neuroectodermal tumor 10.3 SYP ENO2
37 urinary bladder villous adenoma 10.3 KRT7 KRT20
38 lacrimal gland mucoepidermoid carcinoma 10.3 KRT7 KRT20
39 pancreatic gastrinoma 10.3 SYP CHGA
40 anal canal adenocarcinoma 10.3 KRT7 KRT20
41 ovary leiomyosarcoma 10.3 SYP CHGA
42 cerebellar liponeurocytoma 10.3 SYP ENO2
43 vulva adenocarcinoma 10.3 KRT7 KRT20
44 benign ileal neoplasm 10.3 SYP CHGA
45 aortic malignant tumor 10.3 KRT7 KRT20
46 rectum squamous cell carcinoma 10.3 SYP KRT7
47 lipoma of spermatic cord 10.3 SYP ENO2
48 mucinous ovarian cystadenoma 10.3 KRT7 KRT20
49 melanotic neuroectodermal tumor 10.3 SYP ENO2
50 colonic lymphangioma 10.3 KRT7 KRT20

Graphical network of the top 20 diseases related to Prostate Neuroendocrine Neoplasm:



Diseases related to Prostate Neuroendocrine Neoplasm

Symptoms & Phenotypes for Prostate Neuroendocrine Neoplasm

GenomeRNAi Phenotypes related to Prostate Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in pancreas lineage GR00235-A 8.32 KRT7

MGI Mouse Phenotypes related to Prostate Neuroendocrine Neoplasm:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.65 AR CD44 CHGA ENO2 FOLH1 MYCN
2 cardiovascular system MP:0005385 9.28 AR CD44 CHGA FOLH1 KLK3 MYCN

Drugs & Therapeutics for Prostate Neuroendocrine Neoplasm

Drugs for Prostate Neuroendocrine Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 1 15663-27-1 2767 5702198 441203
2
Carboplatin Approved Phase 1 41575-94-4 10339178 38904
3
Etoposide Approved Phase 1 33419-42-0 36462
4
Picropodophyllin Approved, Investigational Phase 1 518-28-5, 477-47-4 10607 72435
5
Pembrolizumab Approved Phase 1 1374853-91-4 254741536
6
Docetaxel Approved, Investigational Phase 1 114977-28-5 148124
7
Etoposide phosphate Phase 1 16760419
8 Keratolytic Agents Phase 1
9 Antimitotic Agents Phase 1
10 Tubulin Modulators Phase 1
11 Antineoplastic Agents, Immunological Phase 1
12 Dermatologic Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase Ib Trial of Pembrolizumab (MK-3475) With Platinum-Based Chemotherapy in Small Cell/Neuroendocrine Cancers of Urothelium and Prostate Recruiting NCT03582475 Phase 1 Carboplatin;Cisplatin;Docetaxel;Etoposide

Search NIH Clinical Center for Prostate Neuroendocrine Neoplasm

Genetic Tests for Prostate Neuroendocrine Neoplasm

Anatomical Context for Prostate Neuroendocrine Neoplasm

Organs/tissues related to Prostate Neuroendocrine Neoplasm:

MalaCards : Prostate

Publications for Prostate Neuroendocrine Neoplasm

Articles related to Prostate Neuroendocrine Neoplasm:

# Title Authors PMID Year
1
Large-cell neuroendocrine tumor of the prostate: a case report and review of the literature. 62
33957979 2021
2
Frontiers in Genitourinary Pathology. 62
32101057 2020
3
[Giant neuroendocrine tumor of the prostate]. 62
19900394 2009
4
FDG PET-CT demonstration of metastatic neuroendocrine tumor of prostate. 62
18565231 2008
5
Pure primary neuroendocrine tumor of the prostate: a rare entity. 62
16859584 2006
6
Primary and pure neuroendocrine tumor of the prostate. 62
14734001 2004
7
[Neuroendocrine tumor of the prostate. A case report]. 62
11859580 2002
8
[Neuroendocrine tumors of the prostate]. 62
8256680 1993

Variations for Prostate Neuroendocrine Neoplasm

Expression for Prostate Neuroendocrine Neoplasm

Search GEO for disease gene expression data for Prostate Neuroendocrine Neoplasm.

Pathways for Prostate Neuroendocrine Neoplasm

GO Terms for Prostate Neuroendocrine Neoplasm

Sources for Prostate Neuroendocrine Neoplasm

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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