Prostate Neuroendocrine Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Prostate Neuroendocrine Neoplasm

MalaCards integrated aliases for Prostate Neuroendocrine Neoplasm:

Name: Prostate Neuroendocrine Neoplasm ¹¹ ¹⁴ ⁷¹

Neuroendocrine Tumor of the Prostate ¹¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:2992

NCIt ⁴⁹ C5545

UMLS ⁷¹ C1335515

Sources

Summaries for Prostate Neuroendocrine Neoplasm

MalaCards based summary: Prostate Neuroendocrine Neoplasm, also known as neuroendocrine tumor of the prostate, is related to neuroendocrine tumor and neuroendocrine carcinoma. An important gene associated with Prostate Neuroendocrine Neoplasm is REST (RE1 Silencing Transcription Factor), and among its related pathways/superpathways are Neuroscience and GDNF signaling. The drugs Cisplatin and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include prostate, and related phenotypes are Decreased viability in pancreas lineage and nervous system

Sources

Related Diseases for Prostate Neuroendocrine Neoplasm

Diseases related to Prostate Neuroendocrine Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 358)

#	Related Disease	Score	Top Affiliating Genes
1	neuroendocrine tumor	30.3	SYP NCAM1 KRT20 ENO2 CHGA
2	neuroendocrine carcinoma	29.1	SYP PTPRC NCAM1 KRT7 KRT20 ENO2
3	suppression of tumorigenicity 12	28.5	TMPRSS2 SYP MYCN KLK3 FOLH1 ENO2
4	prostate cancer	10.4
5	sclerosing hemangioma	10.3	SYP CHGA
6	eyelid benign neoplasm	10.3	KRT20 CHGA
7	mixed ductal-endocrine carcinoma	10.3	SYP CHGA
8	vulvar eccrine porocarcinoma	10.3	SYP CHGA
9	cervical large cell neuroendocrine carcinoma	10.3	SYP CHGA
10	duodenal benign neoplasm	10.3	SYP CHGA
11	acinar cell cystadenocarcinoma	10.3	SYP CHGA
12	mucinous cystadenofibroma	10.3	SYP KRT7
13	gastric gastrinoma	10.3	SYP CHGA
14	malignant melanocytic neoplasm of the peripheral nerve sheath	10.3	SYP ENO2
15	ectopic cushing syndrome	10.3	SYP CHGA
16	bile duct signet ring cell carcinoma	10.3	KRT7 KRT20
17	binswanger's disease	10.3	SYP CHGA
18	neuronal intestinal dysplasia, type b	10.3	SYP ENO2
19	benign perivascular tumor	10.3	SYP CHGA
20	optic nerve astrocytoma	10.3	SYP ENO2
21	urethral villous adenoma	10.3	KRT7 KRT20
22	duodenal gastrinoma	10.3	SYP CHGA
23	cloacogenic carcinoma	10.3	SYP ENO2
24	pineal region teratoma	10.3	SYP ENO2
25	vaginal glandular tumor	10.3	ENO2 CHGA
26	nephrogenic adenoma of urinary bladder	10.3	KRT7 KRT20
27	pancreatic serous cystadenocarcinoma	10.3	KRT7 KRT20
28	ovary neuroendocrine neoplasm	10.3	SYP KRT7
29	atrophic vulva	10.3	KRT7 KRT20
30	bile duct mucinous adenocarcinoma	10.3	SYP ENO2
31	mucinous bronchioloalveolar adenocarcinoma	10.3	KRT7 KRT20
32	glomangioma	10.3	SYP CHGA
33	bladder benign neoplasm	10.3	KRT7 KRT20
34	extra-adrenal pheochromocytoma	10.3	SYP CHGA
35	partial cryptophthalmia	10.3	SYP ENO2
36	intracranial primitive neuroectodermal tumor	10.3	SYP ENO2
37	urinary bladder villous adenoma	10.3	KRT7 KRT20
38	lacrimal gland mucoepidermoid carcinoma	10.3	KRT7 KRT20
39	pancreatic gastrinoma	10.3	SYP CHGA
40	anal canal adenocarcinoma	10.3	KRT7 KRT20
41	ovary leiomyosarcoma	10.3	SYP CHGA
42	cerebellar liponeurocytoma	10.3	SYP ENO2
43	vulva adenocarcinoma	10.3	KRT7 KRT20
44	benign ileal neoplasm	10.3	SYP CHGA
45	aortic malignant tumor	10.3	KRT7 KRT20
46	rectum squamous cell carcinoma	10.3	SYP KRT7
47	lipoma of spermatic cord	10.3	SYP ENO2
48	mucinous ovarian cystadenoma	10.3	KRT7 KRT20
49	melanotic neuroectodermal tumor	10.3	SYP ENO2
50	colonic lymphangioma	10.3	KRT7 KRT20

Graphical network of the top 20 diseases related to Prostate Neuroendocrine Neoplasm:

Sources

Symptoms & Phenotypes for Prostate Neuroendocrine Neoplasm

GenomeRNAi Phenotypes related to Prostate Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability in pancreas lineage	GR00235-A	8.32	KRT7

MGI Mouse Phenotypes related to Prostate Neuroendocrine Neoplasm:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	nervous system	MP:0003631	9.65	AR CD44 CHGA ENO2 FOLH1 MYCN
2	cardiovascular system	MP:0005385	9.28	AR CD44 CHGA FOLH1 KLK3 MYCN

Sources

Drugs & Therapeutics for Prostate Neuroendocrine Neoplasm

Drugs for Prostate Neuroendocrine Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Cisplatin

Approved

Phase 1

15663-27-1

2767 5702198 441203

2

Carboplatin

Approved

Phase 1

41575-94-4

10339178 38904

3

Etoposide

Approved

Phase 1

33419-42-0

36462

Synonyms:

(-)-Etoposide

(−)-ETOPOSIDE

4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylidene-b-D-glucopyranoside)

4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylidene-beta-D-glucopyranoside)

4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylidene-β-D-glucopyranoside)

4-Demethylepipodophyllotoxin b-D-ethylideneglucoside

4-Demethylepipodophyllotoxin beta-D-ethylideneglucoside

4-Demethylepipodophyllotoxin β-D-ethylideneglucoside

9-((4,6-O-Ethylidine-b-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,4-dimethyloxyphenyl)furo(3',4'':6,7)naptho-(2,3-D)-1,3-dioxol-6(5ah)-one

9-((4,6-O-Ethylidine-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,4-dimethyloxyphenyl)furo(3',4'':6,7)naptho-(2,3-D)-1,3-dioxol-6(5ah)-one

9-((4,6-O-Ethylidine-β-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,4-dimethyloxyphenyl)furo(3',4'':6,7)naptho-(2,3-D)-1,3-dioxol-6(5ah)-one

alpha-D-Glucopyranosyl isomer etoposide

Baxter brand OF etoposide

Baxter oncology brand OF etoposide

Bristol myers brand OF etoposide

Bristol myers squibb brand OF etoposide

Bristol-myers brand OF etoposide

Bristol-myers squibb brand OF etoposide

Celltop

Demethyl epipodophyllotoxin ethylidine glucoside

Eposide

Eposin

Eto gry

Eto-gry

Etomedac

Etopophos

Etopos

ETOPOSIDE

Etoposide pierre fabre

Etoposide teva

Etoposide, (5a alpha)-isomer

Etoposide, (5a alpha,9 alpha)-isomer

Etoposide, (5S)-isomer

Etoposide, alpha D glucopyranosyl isomer

Etoposide, alpha-D-glucopyranosyl isomer

Etoposido

Etoposido ferrer farma

Etoposidum

Etoposidum [INN-Latin]

Exitop

Ferrer brand OF etoposide

Gry brand OF etoposide

Lastet

Lemery brand OF etoposide

Medac brand OF etoposide

Novartis brand OF etoposide

NSC-141540

Onkoposid

Onkoworks brand OF etoposide

Pharmachemie brand OF etoposide

Pierre fabre brand OF etoposide

Prasfarma brand OF etoposide

Riboposid

Ribosepharm brand OF etoposide

Sanfer brand OF etoposide

Tedec meiji brand OF etoposide

Teva brand OF etoposide

Teva, etoposide

Toposar

trans-Etoposide

Vepesid

Vepesid J

Vépéside sandoz

Vépéside-sandoz

VP 16

VP 16-213

VP-16

VP-16-213

Zuyeyidal

4

Picropodophyllin

Approved, Investigational

Phase 1

518-28-5, 477-47-4

10607 72435

5

Pembrolizumab

Approved

Phase 1

1374853-91-4

254741536

6

Docetaxel

Approved, Investigational

Phase 1

114977-28-5

148124

7

Etoposide phosphate

Phase 1

16760419

8

Keratolytic Agents

Phase 1

9

Antimitotic Agents

Phase 1

10

Tubulin Modulators

Phase 1

11

Antineoplastic Agents, Immunological

Phase 1

12

Dermatologic Agents

Phase 1

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Phase Ib Trial of Pembrolizumab (MK-3475) With Platinum-Based Chemotherapy in Small Cell/Neuroendocrine Cancers of Urothelium and Prostate	Recruiting	NCT03582475	Phase 1	Carboplatin;Cisplatin;Docetaxel;Etoposide

Search NIH Clinical Center for Prostate Neuroendocrine Neoplasm

Sources

Genetic Tests for Prostate Neuroendocrine Neoplasm

Sources

Anatomical Context for Prostate Neuroendocrine Neoplasm

Organs/tissues related to Prostate Neuroendocrine Neoplasm:

MalaCards : Prostate

Sources

Publications for Prostate Neuroendocrine Neoplasm

Articles related to Prostate Neuroendocrine Neoplasm:

#	Title	Authors	PMID	Year
1	Large-cell neuroendocrine tumor of the prostate: a case report and review of the literature. ⁶²	Sleiman W...Coloby P	33957979	2021
2	Frontiers in Genitourinary Pathology. ⁶²	Huang J...Zhang L	32101057	2020
3	[Giant neuroendocrine tumor of the prostate]. ⁶²	Kuenkel MR...Martorell Mateu ME	19900394	2009
4	FDG PET-CT demonstration of metastatic neuroendocrine tumor of prostate. ⁶²	Liu Y	18565231	2008
5	Pure primary neuroendocrine tumor of the prostate: a rare entity. ⁶²	Ketata S...Mhiri MN	16859584	2006
6	Primary and pure neuroendocrine tumor of the prostate. ⁶²	Freschi M...Rigatti P	14734001	2004
7	[Neuroendocrine tumor of the prostate. A case report]. ⁶²	Zannoud M...Abbar M	11859580	2002
8	[Neuroendocrine tumors of the prostate]. ⁶²	Bours AF...Van Ruyssevelt C	8256680	1993

Sources

Genes for Prostate Neuroendocrine Neoplasm

Genes related to Prostate Neuroendocrine Neoplasm (0 elite genes):

(show all 15)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	REST	RE1 Silencing Transcription Factor	Protein Coding	5.18	DISEASES inferred ¹⁴
2	KRT20	Keratin 20	Protein Coding	4.74	DISEASES inferred ¹⁴
3	SYP	Synaptophysin	Protein Coding	4.58	DISEASES inferred ¹⁴
4	CHGA	Chromogranin A	Protein Coding	4.55	DISEASES inferred ¹⁴
5	AURKA	Aurora Kinase A	Protein Coding	4.45	DISEASES inferred ¹⁴
6	TMPRSS2	Transmembrane Serine Protease 2	Protein Coding	4.17	DISEASES inferred ¹⁴
7	ENO2	Enolase 2	Protein Coding	4.11	DISEASES inferred ¹⁴
8	KRT7	Keratin 7	Protein Coding	4.1	DISEASES inferred ¹⁴
9	MYCN	MYCN Proto-Oncogene, BHLH Transcription Factor	Protein Coding	4.07	DISEASES inferred ¹⁴
10	KLK3	Kallikrein Related Peptidase 3	Protein Coding	3.82	DISEASES inferred ¹⁴
11	NCAM1	Neural Cell Adhesion Molecule 1	Protein Coding	3.81	DISEASES inferred ¹⁴
12	AR	Androgen Receptor	Protein Coding	3.68	DISEASES inferred ¹⁴
13	PTPRC	Protein Tyrosine Phosphatase Receptor Type C	Protein Coding	3.52	DISEASES inferred ¹⁴
14	CD44	CD44 Molecule (Indian Blood Group)	Protein Coding	3.46	DISEASES inferred ¹⁴
15	FOLH1	Folate Hydrolase 1	Protein Coding	2.82	DISEASES inferred ¹⁴

Sources

Variations for Prostate Neuroendocrine Neoplasm

Sources

Expression for Prostate Neuroendocrine Neoplasm

Search GEO for disease gene expression data for Prostate Neuroendocrine Neoplasm.

Sources

Pathways for Prostate Neuroendocrine Neoplasm

Pathways related to Prostate Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Neuroscience ³	12.2	SYP NCAM1 MYCN ENO2
2	GDNF signaling ⁷⁴	11.75	SYP NCAM1 MYCN
3	Adhesion ³	11.7	NCAM1 KLK3 CD44
4	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁵	11.64	PTPRC NCAM1 CD44
5	Mesenchymal Stem Cells and Lineage-specific Markers ⁶⁵	11.48	PTPRC NCAM1 CD44
6	Innate Lymphoid Cells Differentiation ⁶⁵	11.34	PTPRC NCAM1 CD44
7	Neural Stem Cells and Lineage-specific Markers ⁶⁵	11.23	SYP NCAM1 CD44
8	Coregulation of Androgen receptor activity ⁶¹	10.92	TMPRSS2 KLK3 AR
9	Regulation of Androgen receptor activity ⁶¹	10.49	TMPRSS2 KLK3 AR

Sources

GO Terms for Prostate Neuroendocrine Neoplasm

Sources

Sources for Prostate Neuroendocrine Neoplasm

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: PRS017 MIFTS: 27	Prostate Neuroendocrine Neoplasm Categories: Cancer diseases, Neuronal diseases, Reproductive diseases	Data Licensing For inquiries, contact: [email protected]
Genes Tissues Related diseases Publications Drugs Expand all tables