MCID: PRS043
MIFTS: 30

Prostate Rhabdomyosarcoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Prostate Rhabdomyosarcoma

MalaCards integrated aliases for Prostate Rhabdomyosarcoma:

Name: Prostate Rhabdomyosarcoma 12 15 17 70
Rhabdomyosarcoma of the Prostate 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3252
NCIt 50 C5522
UMLS 70 C1335518

Summaries for Prostate Rhabdomyosarcoma

Disease Ontology : 12 A rhabdomyosarcoma and sarcoma of prostate that is located in the prostate.

MalaCards based summary : Prostate Rhabdomyosarcoma, also known as rhabdomyosarcoma of the prostate, is related to prostate embryonal rhabdomyosarcoma and embryonal sarcoma. An important gene associated with Prostate Rhabdomyosarcoma is MIR1915HG (MIR1915 Host Gene), and among its related pathways/superpathways are Myogenesis and Regulation of retinoblastoma protein. Affiliated tissues include prostate, skeletal muscle and colon, and related phenotype is Decreased human cytomegalovirus (HCMV) strain AD169 replication.

Related Diseases for Prostate Rhabdomyosarcoma

Diseases related to Prostate Rhabdomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 prostate embryonal rhabdomyosarcoma 31.6 MYOG MYOD1
2 embryonal sarcoma 29.9 MYOG MYOD1
3 botryoid rhabdomyosarcoma 29.8 MYOG MYOD1
4 spindle cell rhabdomyosarcoma 29.8 MYOG MYOD1
5 embryonal rhabdomyosarcoma 29.7 MYOG MYOD1
6 rhabdomyosarcoma 2 29.7 MYOG MYOD1
7 prostate sarcoma 29.3 TMEM168 MYOG MIR1915HG CKMT2
8 rhabdomyosarcoma 10.6
9 sudden infant death syndrome 10.0
10 hydronephrosis 10.0
11 rare soft tissue tumor 10.0
12 rare tumor 10.0
13 pineal region teratoma 10.0 MYOG MYOD1
14 conventional leiomyosarcoma 10.0 MYOG MYOD1
15 skeletal muscle neoplasm 10.0 MYOG MYOD1
16 undifferentiated embryonal sarcoma of the liver 10.0 MYOG MYOD1
17 inflammatory leiomyosarcoma 9.9 MYOG MYOD1
18 gallbladder sarcoma 9.9 MYOG MYOD1
19 bladder sarcoma 9.9 MYOG MYOD1
20 central nervous system mesenchymal non-meningothelial tumor 9.9 MYOG MYOD1
21 adult fibrosarcoma 9.9 MYOG MYOD1
22 malignant triton tumor 9.9 MYOG MYOD1
23 dressler's syndrome 9.9 CKMT2 CKMT1A CKB
24 prostate stromal sarcoma 9.9 MYOG MYOD1
25 malignant mesenchymoma 9.9 MYOG MYOD1
26 extraosseous ewing sarcoma 9.9 MYOG MYOD1
27 cervical adenosarcoma 9.9 MYOG MYOD1
28 breast rhabdomyosarcoma 9.9 MYOG MYOD1
29 gas gangrene 9.9 MYOG MYOD1
30 pleomorphic rhabdomyosarcoma 9.9 MYOG MYOD1
31 mesenchymal chondrosarcoma 9.9 MYOG MYOD1
32 emery-dreifuss muscular dystrophy 2, autosomal dominant 9.9 MYOG MYOD1
33 desmoplastic small round cell tumor 9.9 MYOG MYOD1
34 sarcoma 9.9
35 neurogenic bladder 9.9
36 detrusor sphincter dyssynergia 9.9
37 impotence 9.9
38 constipation 9.9
39 proctitis 9.9
40 spindle cell sarcoma 9.9
41 soft tissue sarcoma 9.9
42 skeletal muscle cancer 9.8 MYOG MYOD1
43 muscle cancer 9.8 MYOG MYOD1
44 rhabdoid cancer 9.8 MYOG MYOD1
45 malignant fibrous histiocytoma 9.8 MYOG MYOD1
46 alveolar soft part sarcoma 9.7 MYOG MYOD1
47 hemophagocytic lymphohistiocytosis, familial, 1 9.6 MYOG MYOD1
48 neuromuscular disease 9.4 MYOG MYOD1 CKM

Graphical network of the top 20 diseases related to Prostate Rhabdomyosarcoma:



Diseases related to Prostate Rhabdomyosarcoma

Symptoms & Phenotypes for Prostate Rhabdomyosarcoma

GenomeRNAi Phenotypes related to Prostate Rhabdomyosarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased human cytomegalovirus (HCMV) strain AD169 replication GR00248-A 8.62 CKM CKMT2

Drugs & Therapeutics for Prostate Rhabdomyosarcoma

Search Clinical Trials , NIH Clinical Center for Prostate Rhabdomyosarcoma

Genetic Tests for Prostate Rhabdomyosarcoma

Anatomical Context for Prostate Rhabdomyosarcoma

The Foundational Model of Anatomy Ontology organs/tissues related to Prostate Rhabdomyosarcoma:

19
Prostate

MalaCards organs/tissues related to Prostate Rhabdomyosarcoma:

40
Prostate, Skeletal Muscle, Colon, Liver, Breast, Pineal

Publications for Prostate Rhabdomyosarcoma

Articles related to Prostate Rhabdomyosarcoma:

(show top 50) (show all 119)
# Title Authors PMID Year
1
The Role of Reconstructive Surgery and Brachytherapy in Pediatric Bladder/Prostate Rhabdomyosarcoma. 61
32379564 2020
2
Rhabdomyosarcoma of the prostate with bladder and urethral infiltration: A case report. 61
32322519 2020
3
Chemoradiotherapy-induced Cytodifferentiation in Bladder/Prostate Rhabdomyosarcoma With Genetic Downregulation of Myogenin and MyoD1 Gene Expression: A Case Study and Review of the Literature. 61
31945380 2020
4
Epidemiology and survival outcome of adult kidney, bladder, and prostate rhabdomyosarcoma: A SEER database analysis. 61
33329884 2020
5
Patterns of failure and toxicity profile following proton beam therapy for pediatric bladder and prostate rhabdomyosarcoma. 61
31397065 2019
6
Current treatment of pediatric bladder and prostate rhabdomyosarcoma (bladder preserving vs. radical cystectomy). 61
31188163 2019
7
Laparoscopic Bladder-Sparing Approach in Patients with Prostatic Rhabdomyosarcoma: A Case Series of Two Pediatric Patients. 61
31328249 2019
8
A Case of Adult Metastatic Rhabdomyosarcoma of the Prostate Cured by Long-Term Chemotherapy with Local Radiation. 61
28427078 2019
9
Testicular transposition in children undergoing brachytherapy for bladder and/or prostate rhabdomyosarcoma. 61
29753523 2018
10
Appraisal of the role of radical prostatectomy for rhabdomyosarcoma in children: oncological and urological outcome. 61
29899760 2018
11
Current Treatment of Pediatric Bladder and Prostate Rhabdomyosarcoma. 61
29468476 2018
12
Pulsed-dose rate brachytherapy for pediatric bladder prostate rhabdomyosarcoma: Compliance and early clinical results. 61
28760484 2017
13
Brachytherapy Combined With Surgery for Conservative Treatment of Children With Bladder Neck and/or Prostate Rhabdomyosarcoma. 61
28463154 2017
14
Improvements in the Treatment of Patients Suffering from Bladder-Prostate Rhabdomyosarcoma: A Report from the CWS-2002P Trial. 61
27387676 2016
15
Conservative surgery with combined high dose rate brachytherapy for patients suffering from genitourinary and perianal rhabdomyosarcoma. 61
27793447 2016
16
Prognostic factors in children undergoing salvage surgery for bladder/prostate rhabdomyosarcoma. 61
27255731 2016
17
Spindle cell embryonal rhabdomyosarcoma of the prostate in an adult patient - case report and review of clinicopathological features. 61
27357857 2016
18
Quality of life and functional outcome of male patients with bladder-prostate rhabdomyosarcoma treated with conservative surgery and brachytherapy during childhood. 61
26895712 2016
19
Current standards of care in bladder and prostate rhabdomyosarcoma. 61
26776454 2016
20
Pediatric bladder/prostate rhabdomyosarcoma: Eight cases from a single center. 61
28266189 2016
21
Contrast-enhanced ultrasound aids in the detection of prostate rhabdomyosarcoma: A case report and literature review. 61
26622705 2015
22
A review on surgical techniques and organ sparing procedures in bladder/prostate rhabdomyosarcoma. 61
25486411 2014
23
Prostate sarcoma: report of 2 cases and bibliographic review. 61
25306988 2014
24
Oncologic outcome and urinary function after radical cystectomy for rhabdomyosarcoma in children: role of the orthotopic ileal neobladder based on 15-year experience at a single center. 61
24384158 2014
25
Assessment of volume segmentation in radiotherapy of adolescents; a treatment planning study by the Swedish Workgroup for Paediatric Radiotherapy. 61
23577745 2014
26
A case of primary spindle cell variant of embryonal rhabdomyosarcoma of the prostate. 61
25197394 2014
27
Optimal surgical treatment and urological outcomes in boys with pelvic and urogenital rhabdomyosarcomas and soft tissue sarcomas. 61
23989524 2013
28
Spindle cell rhabdomyosarcoma of the prostate. 61
23320845 2013
29
The surgical management of paediatric bladder and prostate rhabdomyosarcoma. 61
26579243 2013
30
Editorial comment on: The surgical management of paediatric bladder and prostate rhabdomyosarcoma. 61
26579244 2013
31
What is the evidence for radical surgery in the management of localized embryonal bladder/prostate rhabdomyosarcoma? 61
22287287 2012
32
Proton radiotherapy for pediatric bladder/prostate rhabdomyosarcoma: clinical outcomes and dosimetry compared to intensity-modulated radiation therapy. 61
20934266 2011
33
Primary embryonal rhabdomyosarcoma of the prostate in adults: report of a case and review of the literature. 61
21427103 2011
34
Comparison of different adjuvant radiotherapy approaches in childhood bladder/prostate rhabdomyosarcoma treated with conservative surgery. 61
22037652 2011
35
Treatment efficiency, outcome and surgical treatment problems in patients suffering from localized embryonal bladder/prostate rhabdomyosarcoma: a report from the Cooperative Soft Tissue Sarcoma trial CWS-96. 61
21370402 2011
36
Symphysiotomy: a valuable approach in children with prostate rhabdomyosarcoma. 61
19904545 2010
37
Embryonal rhabdomyosarcoma of the prostate. 61
20087615 2010
38
Primary embryonal rhabdomyosarcoma of the prostate in an adult. 61
20135959 2010
39
Mixed embryonal/alveolar rhabdomyosarcoma of the prostate: report of a case with molecular genetic studies and literature review. 61
19175284 2009
40
Embryonal prostatic rhabdomyosarcomas disguised presentation in an adolescent male: a case report. 61
19918470 2009
41
Bilateral pulmonary alveolar infiltrate and prostate tumour in a 54-year-old man. 61
21686581 2009
42
Second cancers in children treated with modern radiotherapy techniques. 61
18707783 2008
43
Colon pouch (Mainz III) for continent urinary diversion. 61
17346278 2007
44
Bladder/prostate rhabdomyosarcoma: miles to go before we sleep. 61
16952611 2006
45
Bladder/prostate rhabdomyosarcoma: past, present and future. 61
16952614 2006
46
Significance of persistent mature rhabdomyoblasts in bladder/prostate rhabdomyosarcoma: Results from IRS IV. 61
17006261 2006
47
Transpubic radical prostatectomy: a novel approach for rhabdomyosarcoma of the prostate in children. 61
16598509 2006
48
Does the less aggressive multimodal approach of treating bladder-prostate rhabdomyosarcoma preserve bladder function? 61
16280839 2005
49
[Prostate rhabdomyosarcoma]. 61
15666531 2004
50
Re: Does bladder preservation (as a surgical principle) lead to retaining bladder function in bladder/prostate rhabdomyosarcoma? Results from Intergroup Rhabdomyosarcoma Study IV. 61
15540797 2004

Variations for Prostate Rhabdomyosarcoma

Expression for Prostate Rhabdomyosarcoma

Search GEO for disease gene expression data for Prostate Rhabdomyosarcoma.

Pathways for Prostate Rhabdomyosarcoma

Pathways related to Prostate Rhabdomyosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.09 MYOG MYOD1
2 11 MYOD1 CKM
3
Show member pathways
10.69 CKMT2 CKMT1A CKM CKB
4
Show member pathways
10.54 CKM CKB
5
Show member pathways
10.1 CKM CKB

GO Terms for Prostate Rhabdomyosarcoma

Biological processes related to Prostate Rhabdomyosarcoma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 phosphorylation GO:0016310 9.8 CKMT2 CKMT1A CKM CKB
2 skeletal muscle tissue development GO:0007519 9.54 MYOG MYOD1
3 skeletal muscle cell differentiation GO:0035914 9.52 MYOG MYOD1
4 cellular response to estradiol stimulus GO:0071392 9.51 MYOG MYOD1
5 positive regulation of muscle cell differentiation GO:0051149 9.48 MYOG MYOD1
6 skeletal muscle fiber development GO:0048741 9.46 MYOG MYOD1
7 skeletal muscle tissue regeneration GO:0043403 9.43 MYOG MYOD1
8 positive regulation of myoblast differentiation GO:0045663 9.4 MYOG MYOD1
9 myoblast differentiation GO:0045445 9.37 MYOG MYOD1
10 myotube differentiation GO:0014902 9.32 MYOG MYOD1
11 positive regulation of skeletal muscle fiber development GO:0048743 9.26 MYOG MYOD1
12 creatine metabolic process GO:0006600 9.26 CKMT2 CKMT1A CKM CKB
13 muscle cell fate commitment GO:0042693 9.16 MYOG MYOD1
14 phosphocreatine biosynthetic process GO:0046314 8.92 CKMT2 CKMT1A CKM CKB

Molecular functions related to Prostate Rhabdomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transferase activity GO:0016740 9.77 CKMT2 CKMT1A CKM CKB BMT2
2 kinase activity GO:0016301 9.56 CKMT2 CKMT1A CKM CKB
3 catalytic activity GO:0003824 9.46 CKMT2 CKMT1A CKM CKB
4 proximal promoter sequence-specific DNA binding GO:0000987 9.43 MYOG MYOD1
5 chromatin DNA binding GO:0031490 9.4 MYOG MYOD1
6 E-box binding GO:0070888 9.32 MYOG MYOD1
7 transferase activity, transferring phosphorus-containing groups GO:0016772 9.26 CKMT2 CKMT1A CKM CKB
8 creatine kinase activity GO:0004111 8.92 CKMT2 CKMT1A CKM CKB

Sources for Prostate Rhabdomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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