MCID: PRS015
MIFTS: 13

Prostate Signet Ring Cell Adenocarcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Prostate Signet Ring Cell Adenocarcinoma

MalaCards integrated aliases for Prostate Signet Ring Cell Adenocarcinoma:

Name: Prostate Signet Ring Cell Adenocarcinoma 12 15
Acinar Prostate Adenocarcinoma, Signet Ring Variant 73
Signet Ring Cell Carcinoma of Prostate 12
Prostate Signet Ring Cell Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3504
NCIt 50 C5535
UMLS 73 C1335520

Summaries for Prostate Signet Ring Cell Adenocarcinoma

MalaCards based summary : Prostate Signet Ring Cell Adenocarcinoma, also known as acinar prostate adenocarcinoma, signet ring variant, is related to signet ring cell adenocarcinoma and female urethral cancer. An important gene associated with Prostate Signet Ring Cell Adenocarcinoma is KLK3 (Kallikrein Related Peptidase 3), and among its related pathways/superpathways is Adhesion. Affiliated tissues include prostate.

Related Diseases for Prostate Signet Ring Cell Adenocarcinoma

Diseases related to Prostate Signet Ring Cell Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 signet ring cell adenocarcinoma 10.2
2 female urethral cancer 9.6 CEACAM5 KLK3
3 rete testis adenocarcinoma 9.5 CEACAM5 KLK3
4 urethral benign neoplasm 9.5 CEACAM5 KLK3
5 rete testis neoplasm 9.4 CEACAM5 KLK3
6 prostate squamous cell carcinoma 9.3 CEACAM5 KLK3
7 cell type cancer 9.2 CEACAM5 KLK3
8 adamantinoma of long bones 9.0 CEACAM5 KLK3

Graphical network of the top 20 diseases related to Prostate Signet Ring Cell Adenocarcinoma:



Diseases related to Prostate Signet Ring Cell Adenocarcinoma

Symptoms & Phenotypes for Prostate Signet Ring Cell Adenocarcinoma

Drugs & Therapeutics for Prostate Signet Ring Cell Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Prostate Signet Ring Cell Adenocarcinoma

Genetic Tests for Prostate Signet Ring Cell Adenocarcinoma

Anatomical Context for Prostate Signet Ring Cell Adenocarcinoma

MalaCards organs/tissues related to Prostate Signet Ring Cell Adenocarcinoma:

41
Prostate

Publications for Prostate Signet Ring Cell Adenocarcinoma

Variations for Prostate Signet Ring Cell Adenocarcinoma

Cosmic variations for Prostate Signet Ring Cell Adenocarcinoma:

9
(show top 50) (show all 2438)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6930186 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.5114C>G p.S1705* 16:72797568-72797568 10
2 COSM1640552 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.8849G>A p.R2950H 16:72793833-72793833 10
3 COSM6982069 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.2728G>A p.E910K 16:72950957-72950957 10
4 COSM6984715 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.5893C>T p.Q1965* 16:72796789-72796789 10
5 COSM6965403 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.4819C>T p.Q1607* 16:72797863-72797863 10
6 COSM6940917 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.3533C>A p.S1178* 16:72812035-72812035 10
7 COSM6845138 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.5650G>T p.E1884* 16:72797032-72797032 10
8 COSM3276891 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.3340C>T p.R1114* 16:72889839-72889839 10
9 COSM1270844 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.6445C>T p.R2149C 16:72796237-72796237 10
10 COSM6984205 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.2986A>T p.K996* 16:72950699-72950699 10
11 COSM6958286 ZFHX3 prostate,NS,carcinoma,adenocarcinoma c.405C>G p.Y135* 16:72959741-72959741 10
12 COSM6909179 YES1 prostate,NS,carcinoma,adenocarcinoma c.119C>G p.S40* 18:756709-756709 10
13 COSM6921346 XPO1 prostate,NS,carcinoma,adenocarcinoma c.1098T>A p.F366L 2:61494041-61494041 10
14 COSM6928801 XPO1 prostate,NS,carcinoma,adenocarcinoma c.1384G>T p.V462F 2:61492915-61492915 10
15 COSM6984689 XPO1 prostate,NS,carcinoma,adenocarcinoma c.2468T>G p.F823C 2:61485808-61485808 10
16 COSM96797 XPO1 prostate,NS,carcinoma,adenocarcinoma c.1711G>A p.E571K 2:61492337-61492337 10
17 COSM6918424 XPO1 prostate,NS,carcinoma,adenocarcinoma c.3101T>G p.F1034C 2:61478935-61478935 10
18 COSM6918912 XPO1 prostate,NS,carcinoma,adenocarcinoma c.1259T>C p.M420T 2:61493040-61493040 10
19 COSM6934737 WT1 prostate,NS,carcinoma,adenocarcinoma c.904C>T p.R302C 11:32396398-32396398 10
20 COSM1675924 WT1 prostate,NS,carcinoma,adenocarcinoma c.790C>G p.Q264E 11:32416497-32416497 10
21 COSM1475372 WT1 prostate,NS,carcinoma,adenocarcinoma c.1297C>T p.R433C 11:32389111-32389111 10
22 COSM6975064 WT1 prostate,NS,carcinoma,adenocarcinoma c.1149C>A p.F383L 11:32392051-32392051 10
23 COSM14311 VHL prostate,NS,carcinoma,adenocarcinoma c.499C>T p.R167W 3:10149822-10149822 10
24 COSM6952050 VHL prostate,NS,carcinoma,adenocarcinoma c.242C>A p.P81Q 3:10142089-10142089 10
25 COSM6946750 VHL prostate,NS,carcinoma,adenocarcinoma c.219G>C p.Q73H 3:10142066-10142066 10
26 COSM1130534 U2AF1 prostate,NS,carcinoma,adenocarcinoma c.692C>T p.S231L 21:43093133-43093133 10
27 COSM6971109 TSC2 prostate,NS,carcinoma,adenocarcinoma c.1385G>A p.R462H 16:2062995-2062995 10
28 COSM6980192 TSC2 prostate,NS,carcinoma,adenocarcinoma c.4388T>A p.I1463N 16:2084610-2084610 10
29 COSM6005603 TSC2 prostate,NS,carcinoma,adenocarcinoma c.472G>A p.E158K 16:2054431-2054431 10
30 COSM6005601 TSC2 prostate,NS,carcinoma,adenocarcinoma c.392C>A p.P131H 16:2054351-2054351 10
31 COSM3212813 TSC1 prostate,NS,carcinoma,adenocarcinoma c.3100G>T p.G1034C 9:132896630-132896630 10
32 COSM3212858 TSC1 prostate,NS,carcinoma,adenocarcinoma c.439G>T p.G147W 9:132923417-132923417 10
33 COSM6939550 TSC1 prostate,NS,carcinoma,adenocarcinoma c.508G>T p.G170C 9:132923348-132923348 10
34 COSM1042486 TP63 prostate,NS,carcinoma,adenocarcinoma c.448G>A p.A150T 3:189808395-189808395 10
35 COSM6954187 TP63 prostate,NS,carcinoma,adenocarcinoma c.490G>A p.A164T 3:189808437-189808437 10
36 COSM6979174 TP63 prostate,NS,carcinoma,adenocarcinoma c.1106A>G p.K369R 3:189868693-189868693 10
37 COSM6930015 TP63 prostate,NS,carcinoma,adenocarcinoma c.1147C>T p.H383Y 3:189869341-189869341 10
38 COSM6978125 TP63 prostate,NS,carcinoma,adenocarcinoma c.728G>A p.R243Q 3:189864380-189864380 10
39 COSM10690 TP53 prostate,NS,carcinoma,adenocarcinoma c.473G>A p.R158H 17:7675139-7675139 10
40 COSM10662 TP53 prostate,NS,carcinoma,adenocarcinoma c.743G>A p.R248Q 17:7674220-7674220 10
41 COSM43906 TP53 prostate,NS,carcinoma,adenocarcinoma c.843C>A p.D281E 17:7673777-7673777 10
42 COSM44319 TP53 prostate,NS,carcinoma,adenocarcinoma c.405C>A p.C135* 17:7675207-7675207 10
43 COSM45620 TP53 prostate,NS,carcinoma,adenocarcinoma c.704A>C p.N235T 17:7674259-7674259 10
44 COSM43657 TP53 prostate,NS,carcinoma,adenocarcinoma c.569C>T p.P190L 17:7674962-7674962 10
45 COSM44578 TP53 prostate,NS,carcinoma,adenocarcinoma c.721T>C p.S241P 17:7674242-7674242 10
46 COSM10808 TP53 prostate,NS,carcinoma,adenocarcinoma c.488A>G p.Y163C 17:7675124-7675124 10
47 COSM12193 TP53 prostate,NS,carcinoma,adenocarcinoma c.668C>T p.P223L 17:7674863-7674863 10
48 COSM43750 TP53 prostate,NS,carcinoma,adenocarcinoma c.811G>T p.E271* 17:7673809-7673809 10
49 COSM43842 TP53 prostate,NS,carcinoma,adenocarcinoma c.770T>C p.L257P 17:7674193-7674193 10
50 COSM10828 TP53 prostate,NS,carcinoma,adenocarcinoma c.785G>A p.G262D 17:7673835-7673835 10

Expression for Prostate Signet Ring Cell Adenocarcinoma

Search GEO for disease gene expression data for Prostate Signet Ring Cell Adenocarcinoma.

Pathways for Prostate Signet Ring Cell Adenocarcinoma

Pathways related to Prostate Signet Ring Cell Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.71 CEACAM5 KLK3

GO Terms for Prostate Signet Ring Cell Adenocarcinoma

Sources for Prostate Signet Ring Cell Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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