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MCID: PRS008
MIFTS: 28

Prostate Small Cell Carcinoma

Categories: Cancer diseases, Reproductive diseases
Genes Variations Tissues Related diseases Publications Pathways
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Aliases & Classifications for Prostate Small Cell Carcinoma

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MalaCards integrated aliases for Prostate Small Cell Carcinoma:

Name: Prostate Small Cell Carcinoma 12 15 17
Small Cell Carcinoma of Prostate 12 71
Prostate Oat Cell Carcinoma 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:7141
NCIt 49 C6766
UMLS 71 C1300585
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Summaries for Prostate Small Cell Carcinoma

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MalaCards based summary : Prostate Small Cell Carcinoma, also known as small cell carcinoma of prostate, is related to prostatic acinar adenocarcinoma and suppression of tumorigenicity 12. An important gene associated with Prostate Small Cell Carcinoma is KDM4C (Lysine Demethylase 4C), and among its related pathways/superpathways is Coregulation of Androgen receptor activity. Affiliated tissues include prostate, lung and brain, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

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Related Diseases for Prostate Small Cell Carcinoma

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Diseases related to Prostate Small Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 24)
# Related Disease Score Top Affiliating Genes
1 prostatic acinar adenocarcinoma 29.3 TMPRSS2 SLC45A3
2 suppression of tumorigenicity 12 28.7 TMPRSS2 SLC45A3 KDM4C FOLH1
3 small cell carcinoma 10.7
4 adenocarcinoma 10.2
5 neuroendocrine carcinoma 10.2
6 syndromic x-linked intellectual disability siderius type 10.1 ZNF526 KDM4C
7 lung oat cell carcinoma 10.1
8 lambert syndrome 9.9
9 bone disease 9.9
10 polyneuropathy 9.9
11 paraneoplastic polyneuropathy 9.9
12 paraneoplastic syndromes 9.9
13 prostate cancer 9.9
14 small cell cancer of the lung 9.9
15 hydronephrosis 9.9
16 hypokalemia 9.9
17 severe combined immunodeficiency 9.9
18 ileus 9.9
19 small cell carcinoma of the bladder 9.9
20 villous adenoma 9.8 SLC45A3 FOLH1
21 prostate neuroendocrine neoplasm 9.6 TMPRSS2 FOLH1
22 retinitis pigmentosa 11 9.4 TMPRSS2 KDM4C
23 male reproductive organ cancer 9.4 TMPRSS2 KDM4C FOLH1
24 male reproductive system disease 9.3 TMPRSS2 KDM4C FOLH1

Graphical network of the top 20 diseases related to Prostate Small Cell Carcinoma:



Diseases related to Prostate Small Cell Carcinoma
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Symptoms & Phenotypes for Prostate Small Cell Carcinoma

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GenomeRNAi Phenotypes related to Prostate Small Cell Carcinoma according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-109 9.44 HECTD1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-150 9.44 HECTD1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.44 INMT
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-175 9.44 SV2B
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-187 9.44 HECTD1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-195 9.44 SV2B
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-209 9.44 SV2B
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.44 HECTD1 INMT SV2B
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.44 HECTD1
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-28 9.44 HECTD1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-38 9.44 INMT
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Drugs & Therapeutics for Prostate Small Cell Carcinoma

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Search Clinical Trials , NIH Clinical Center for Prostate Small Cell Carcinoma

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Genetic Tests for Prostate Small Cell Carcinoma

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Anatomical Context for Prostate Small Cell Carcinoma

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MalaCards organs/tissues related to Prostate Small Cell Carcinoma:

40
Prostate, Lung, Brain, Skin, Bone
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Publications for Prostate Small Cell Carcinoma

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Articles related to Prostate Small Cell Carcinoma:

(show all 29)
# Title Authors PMID Year
1
Current trend of worsening prognosis of prostate small cell carcinoma: A population-based study. 61
31518071 2019
2
Molecular analysis and literature-based hypothesis of an immunonegative prostate small cell carcinoma causing ectopic ACTH syndrome. 61
30918166 2019
3
Small Cell Transformation of Metastatic Prostate Adenocarcinoma Diagnosed by Dual-Tracer PET/CT (68Ga-PSMA and 18F-FDG): Potential Clinical Utility in Therapeutic Decision Making and Treatment Monitoring. 61
30139889 2019
4
Pure Small Cell Carcinoma of Prostate: A Report of 8 Cases. 61
30269133 2018
5
Small Cell Carcinoma of Prostate: A Case Report of a Patient With Concomitant Transitional Cell Cancer of the Bladder. 61
29536021 2018
6
Function of Tumor Suppressors in Resistance to Antiandrogen Therapy and Luminal Epithelial Plasticity of Aggressive Variant Neuroendocrine Prostate Cancers. 61
29600194 2018
7
[Etoposide and Carboplatin Effective for Treatment of Small Cell Carcinoma of Prostate : A Report of Two Cases]. 61
28103658 2016
8
Emerging trends in the evaluation and management of small cell prostate cancer: a clinical and molecular perspective. 61
27534689 2016
9
Primary small cell carcinoma of prostate without immunoreactive neuroendocrine proteins but with expressions of KIT and platelet-derived growth factor-α. 61
25195713 2015
10
Genitourinary small cell malignancies: prostate and bladder. 61
25675127 2015
11
Clinicopathological study of prostatic biopsies. 61
25386437 2014
12
Current approaches for prophylactic cranial irradiation in extrapulmonary small cell carcinoma. 61
24628530 2014
13
Small cell carcinoma of the urinary bladder and prostate: Cytological analyses of four cases with emphasis on the usefulness of cytological examination. 61
24396449 2014
14
Clinical impact of 18F-fluorodeoxyglucose positron emission tomography/computed tomography in the evaluation of small cell carcinoma of the prostate. 61
23218515 2013
15
Prostate small cell carcinoma and skin metastases: a rare entity. 61
18408396 2008
16
Small cell carcinoma of the prostate. A morphologic and immunohistochemical study of 95 cases. 61
18162772 2008
17
Submandibular area metastasis from prostate small cell carcinoma with neuroendocrine differentiation. 61
17912103 2007
18
Extrapulmonary small cell carcinoma of the bladder. 61
17270661 2007
19
[Prostate small cell carcinoma: report of two cases that differed in treatment responsiveness]. 61
17176877 2006
20
[Small cell carcinoma of the prostate: an autopsy case report]. 61
16050480 2005
21
Metastatic pure small-cell carcinoma of prostate. 61
15545846 2004
22
Molecular characterization of prostatic small-cell neuroendocrine carcinoma. 61
12640661 2003
23
Brain metastasis from prostate small cell carcinoma: not to be neglected. 61
12463494 2002
24
[Small cell (oat cell) carcinoma of the prostate. Presentation of a case and review of the literature]. 61
1324565 1992
25
Small cell carcinoma of prostate: effectiveness of hormonal versus chemotherapy. 61
1315995 1992
26
Small-cell carcinoma of prostate. 61
2538948 1989
27
Small cell carcinoma of prostate associated with myasthenic (Eaton-Lambert) syndrome. 61
2536972 1989
28
Small cell carcinoma of prostate. 61
2536204 1989
29
Small-cell carcinoma of prostate. Transient complete remission with chemotherapy. 61
2992147 1985
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Variations for Prostate Small Cell Carcinoma

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Cosmic variations for Prostate Small Cell Carcinoma:

9 (show top 50) (show all 308)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM149310929 ZFHX3 prostate,NS,carcinoma,small cell carcinoma c.709C>T p.R237* 16:72959437-72959437 12
2 COSM143037036 YAP1 prostate,NS,carcinoma,small cell carcinoma c.1126C>T p.Q376* 11:102223703-102223703 12
3 COSM91374081 WT1 prostate,NS,carcinoma,small cell carcinoma c.526C>G p.R176G 11:32434820-32434820 12
4 COSM91374068 WT1 prostate,NS,carcinoma,small cell carcinoma c.544C>T p.P182S 11:32434802-32434802 12
5 COSM87912114 TP53 prostate,NS,carcinoma,small cell carcinoma c.673-2A>C p.? 17:7674292-7674292 12
6 COSM87897745 TP53 prostate,NS,carcinoma,small cell carcinoma c.524G>A p.R175H 17:7675088-7675088 12
7 COSM88004535 TP53 prostate,NS,carcinoma,small cell carcinoma c.717C>G p.N239K 17:7674246-7674246 12
8 COSM87898351 TP53 prostate,NS,carcinoma,small cell carcinoma c.743G>A p.R248Q 17:7674220-7674220 12
9 COSM87898714 TP53 prostate,NS,carcinoma,small cell carcinoma c.844C>T p.R282W 17:7673776-7673776 12
10 COSM87898444 TP53 prostate,NS,carcinoma,small cell carcinoma c.536A>G p.H179R 17:7675076-7675076 12
11 COSM87993047 TP53 prostate,NS,carcinoma,small cell carcinoma c.568C>T p.P190S 17:7674963-7674963 12
12 COSM93617776 SUFU prostate,NS,carcinoma,small cell carcinoma c.196G>T p.D66Y 10:102509182-102509182 12
13 COSM85846727 STAT5B prostate,NS,carcinoma,small cell carcinoma c.319C>T p.R107C 17:42224835-42224835 12
14 COSM100983063 SPOP prostate,NS,carcinoma,small cell carcinoma c.397T>G p.F133V 17:49619064-49619064 12
15 COSM84676025 SMO prostate,NS,carcinoma,small cell carcinoma c.1754A>C p.Q585P 7:129211066-129211066 12
16 COSM103041517 SETD2 prostate,NS,carcinoma,small cell carcinoma c.5548C>T p.R1850C 3:47084232-47084232 12
17 COSM99100525 SDHB prostate,NS,carcinoma,small cell carcinoma c.688C>T p.R230C 1:17022685-17022685 12
18 COSM93213195 RPS6KA4 prostate,NS,carcinoma,small cell carcinoma c.860C>T p.A287V 11:64361956-64361956 12
19 COSM86633737 RB1 prostate,NS,carcinoma,small cell carcinoma c.967G>T p.E323* 13:48367521-48367521 12
20 COSM86643650 RB1 prostate,NS,carcinoma,small cell carcinoma c.1814+1G>T p.? 13:48453112-48453112 12
21 COSM90602983 POLE prostate,NS,carcinoma,small cell carcinoma c.2264T>C p.V755A 12:132667558-132667558 12
22 COSM125308958 PIK3R1 prostate,NS,carcinoma,small cell carcinoma c.469A>C p.N157H 5:68273980-68273980 12
23 COSM125307134 PIK3R1 prostate,NS,carcinoma,small cell carcinoma c.1746-1G>A p.? 5:68295419-68295419 12
24 COSM100368071 PIK3CD prostate,NS,carcinoma,small cell carcinoma c.113G>A p.R38H 1:9710568-9710568 12
25 COSM100371142 PIK3CD prostate,NS,carcinoma,small cell carcinoma c.2608C>T p.R870* 1:9723982-9723982 12
26 COSM100368957 PIK3CD prostate,NS,carcinoma,small cell carcinoma c.2681G>A p.R894Q 1:9724055-9724055 12
27 COSM87135712 PIK3CA prostate,NS,carcinoma,small cell carcinoma c.316G>C p.G106R 3:179199141-179199141 12
28 COSM95458321 PARP1 prostate,NS,carcinoma,small cell carcinoma c.770C>G p.S257* 1:226386390-226386390 12
29 COSM109087837 NSD1 prostate,NS,carcinoma,small cell carcinoma c.5816G>A p.R1939H 5:177280758-177280758 12
30 COSM88400090 NOTCH2 prostate,NS,carcinoma,small cell carcinoma c.3779G>A p.R1260H 1:119929089-119929089 12
31 COSM87704295 NOTCH1 prostate,NS,carcinoma,small cell carcinoma c.4659G>C p.E1553D 9:136505032-136505032 12
32 COSM100293674 NFE2L2 prostate,NS,carcinoma,small cell carcinoma c.1390C>G p.L464V 2:177231213-177231213 12
33 COSM85464110 MSH2 prostate,NS,carcinoma,small cell carcinoma c.907G>C p.D303H 2:47414383-47414383 12
34 COSM129135030 KMT2A prostate,NS,carcinoma,small cell carcinoma c.11366G>A p.R3789H 11:118520001-118520001 12
35 COSM100046872 IRS2 prostate,NS,carcinoma,small cell carcinoma c.553G>T p.G185W 13:109785501-109785501 12
36 COSM100043917 IRS2 prostate,NS,carcinoma,small cell carcinoma c.3366G>C p.Q1122H 13:109782688-109782688 12
37 COSM151681678 IKZF1 prostate,NS,carcinoma,small cell carcinoma c.1543C>T p.R515C 7:50400610-50400610 12
38 COSM112988925 HRAS prostate,NS,carcinoma,small cell carcinoma c.181C>A p.Q61K 11:533875-533875 12
39 COSM91305419 H3-5 prostate,NS,carcinoma,small cell carcinoma c.289G>A p.E97K 12:31791878-31791878 12
40 COSM99108947 GRIN2A prostate,NS,carcinoma,small cell carcinoma c.3506G>A p.R1169Q 16:9764038-9764038 12
41 COSM99132391 GRIN2A prostate,NS,carcinoma,small cell carcinoma c.3662T>C p.M1221T 16:9763882-9763882 12
42 COSM142904528 FOXP1 prostate,NS,carcinoma,small cell carcinoma c.1756A>T p.N586Y 3:70970750-70970750 12
43 COSM84948993 FOXA1 prostate,NS,carcinoma,small cell carcinoma c.655C>A p.R219S 14:37592129-37592129 12
44 COSM84950537 FOXA1 prostate,NS,carcinoma,small cell carcinoma c.511C>T p.P171S 14:37592273-37592273 12
45 COSM88029938 FLT4 prostate,NS,carcinoma,small cell carcinoma c.81G>T p.M27I 5:180631756-180631756 12
46 COSM85522120 FGFR4 prostate,NS,carcinoma,small cell carcinoma c.310C>T p.R104* 5:177090608-177090608 12
47 COSM88598411 ERBB2 prostate,NS,carcinoma,small cell carcinoma c.1318G>A p.A440T 17:39715744-39715744 12
48 COSM102127207 EPHB1 prostate,NS,carcinoma,small cell carcinoma c.1601A>C p.E534A 3:135165983-135165983 12
49 COSM102121776 EPHB1 prostate,NS,carcinoma,small cell carcinoma c.758G>T p.C253F 3:134952005-134952005 12
50 COSM143840741 EPHA5 prostate,NS,carcinoma,small cell carcinoma c.2729A>T p.Q910L 4:65336058-65336058 12
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Expression for Prostate Small Cell Carcinoma

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Search GEO for disease gene expression data for Prostate Small Cell Carcinoma.
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Pathways for Prostate Small Cell Carcinoma

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Pathways related to Prostate Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Coregulation of Androgen receptor activity 1
10.38 TMPRSS2 KDM4C
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GO Terms for Prostate Small Cell Carcinoma

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Sources for Prostate Small Cell Carcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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