MCID: PRS008
MIFTS: 33

Prostate Small Cell Carcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Prostate Small Cell Carcinoma

MalaCards integrated aliases for Prostate Small Cell Carcinoma:

Name: Prostate Small Cell Carcinoma 12 15 17
Small Cell Carcinoma of Prostate 12 72
Prostate Oat Cell Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7141
NCIt 50 C6766
UMLS 72 C1300585

Summaries for Prostate Small Cell Carcinoma

MalaCards based summary : Prostate Small Cell Carcinoma, also known as small cell carcinoma of prostate, is related to small cell carcinoma of the bladder and prostatic acinar adenocarcinoma. An important gene associated with Prostate Small Cell Carcinoma is SV2B (Synaptic Vesicle Glycoprotein 2B). Affiliated tissues include prostate, brain and skin, and related phenotypes are Decreased viability in esophageal squamous lineage and cellular

Related Diseases for Prostate Small Cell Carcinoma

Diseases related to Prostate Small Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 small cell carcinoma of the bladder 30.4 NKX2-1 ENO2
2 prostatic acinar adenocarcinoma 29.9 KLK3 KIT
3 small cell carcinoma 29.1 PTEN NKX2-1 KLK3 KIT ENO2
4 suppression of tumorigenicity 12 28.7 SLC45A3 PTEN KLK3 FOLH1
5 small cell cancer of the lung 28.0 PTEN NKX2-1 KIT ENO2 ASCL1
6 villous adenoma 10.4 KLK3 FOLH1
7 prostatic hyperplasia, benign 10.3 KLK3 FOLH1
8 respiratory system benign neoplasm 10.3 NKX2-1 ENO2
9 carcinoid tumors, intestinal 10.3 NKX2-1 ENO2
10 extraskeletal ewing sarcoma 10.3 NKX2-1 ENO2
11 adenocarcinoma 10.3
12 cutaneous ganglioneuroma 10.2 KIT ENO2
13 maxillary sinus adenoid cystic carcinoma 10.2 KIT FOLH1
14 gastric leiomyosarcoma 10.2 KIT ENO2
15 nodular prostate 10.2 KLK3 FOLH1 ENO2
16 prostate embryonal rhabdomyosarcoma 10.2 KLK3 KIT
17 endometrial small cell carcinoma 10.2 KIT ENO2
18 conventional fibrosarcoma 10.2 KIT ENO2
19 subependymal giant cell astrocytoma 10.2 NKX2-1 ENO2
20 plexiform schwannoma 10.2 KIT ENO2
21 cystic teratoma 10.2 NKX2-1 ENO2
22 prostate rhabdomyosarcoma 10.2 KLK3 KIT
23 angiomyoma 10.2 KIT ENO2
24 horseshoe kidney 10.2 NKX2-1 ENO2
25 neuroendocrine tumor 10.1 NKX2-1 ENO2 ASCL1
26 heart sarcoma 10.1 KIT ENO2
27 neuroendocrine carcinoma 10.1
28 lung oat cell carcinoma 10.1
29 lung adenoid cystic carcinoma 10.0 NKX2-1 KIT
30 cribriform carcinoma 10.0 KIT GATA3
31 cystitis cystica 10.0 KLK3 GATA3
32 sarcomatoid renal cell carcinoma 10.0 KIT GATA3
33 mixed cell type cancer 10.0 KIT ENO2
34 embryoma 10.0 KIT GATA3
35 lambert syndrome 9.9
36 bone disease 9.9
37 polyneuropathy 9.9
38 paraneoplastic polyneuropathy 9.9
39 paraneoplastic syndromes 9.9
40 prostate cancer 9.9
41 hypokalemia 9.9
42 severe combined immunodeficiency 9.9
43 ileus 9.9
44 dysgerminoma of ovary 9.9 KIT ENO2
45 merkel cell carcinoma 9.8 NKX2-1 KIT ENO2
46 teratoma 9.8 NKX2-1 KIT ENO2
47 hyperinsulinemic hypoglycemia, familial, 3 9.8 PTEN AURKA
48 central nervous system melanocytic neoplasm 9.8 KIT ENO2
49 reproductive system disease 9.7 PTEN KLK3 FOLH1
50 mixed type thymoma 9.7 PTEN KIT

Graphical network of the top 20 diseases related to Prostate Small Cell Carcinoma:



Diseases related to Prostate Small Cell Carcinoma

Symptoms & Phenotypes for Prostate Small Cell Carcinoma

GenomeRNAi Phenotypes related to Prostate Small Cell Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.23 ASCL1 AURKA KIT KLK3 NKX2-1 PTEN

MGI Mouse Phenotypes related to Prostate Small Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.92 ASCL1 AURKA ENO2 GATA3 KIT NKX2-1
2 growth/size/body region MP:0005378 9.86 ASCL1 AURKA ENO2 GATA3 KIT NKX2-1
3 normal MP:0002873 9.63 ASCL1 GATA3 KIT NKX2-1 PTEN SV2B
4 pigmentation MP:0001186 9.26 ASCL1 GATA3 KIT PTEN
5 taste/olfaction MP:0005394 8.8 ASCL1 ENO2 PTEN

Drugs & Therapeutics for Prostate Small Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Prostate Small Cell Carcinoma

Genetic Tests for Prostate Small Cell Carcinoma

Anatomical Context for Prostate Small Cell Carcinoma

MalaCards organs/tissues related to Prostate Small Cell Carcinoma:

41
Prostate, Brain, Skin

Publications for Prostate Small Cell Carcinoma

Articles related to Prostate Small Cell Carcinoma:

(show all 28)
# Title Authors PMID Year
1
Molecular analysis and literature-based hypothesis of an immunonegative prostate small cell carcinoma causing ectopic ACTH syndrome. 38
30918166 2019
2
Small Cell Transformation of Metastatic Prostate Adenocarcinoma Diagnosed by Dual-Tracer PET/CT (68Ga-PSMA and 18F-FDG): Potential Clinical Utility in Therapeutic Decision Making and Treatment Monitoring. 38
30139889 2019
3
Pure Small Cell Carcinoma of Prostate: A Report of 8 Cases. 38
30269133 2018
4
Small Cell Carcinoma of Prostate: A Case Report of a Patient With Concomitant Transitional Cell Cancer of the Bladder. 38
29536021 2018
5
Function of Tumor Suppressors in Resistance to Antiandrogen Therapy and Luminal Epithelial Plasticity of Aggressive Variant Neuroendocrine Prostate Cancers. 38
29600194 2018
6
[Etoposide and Carboplatin Effective for Treatment of Small Cell Carcinoma of Prostate : A Report of Two Cases]. 38
28103658 2016
7
Emerging trends in the evaluation and management of small cell prostate cancer: a clinical and molecular perspective. 38
27534689 2016
8
Primary small cell carcinoma of prostate without immunoreactive neuroendocrine proteins but with expressions of KIT and platelet-derived growth factor-α. 38
25195713 2015
9
Genitourinary small cell malignancies: prostate and bladder. 38
25675127 2015
10
Clinicopathological study of prostatic biopsies. 38
25386437 2014
11
Current approaches for prophylactic cranial irradiation in extrapulmonary small cell carcinoma. 38
24628530 2014
12
Small cell carcinoma of the urinary bladder and prostate: Cytological analyses of four cases with emphasis on the usefulness of cytological examination. 38
24396449 2014
13
Clinical impact of 18F-fluorodeoxyglucose positron emission tomography/computed tomography in the evaluation of small cell carcinoma of the prostate. 38
23218515 2013
14
Prostate small cell carcinoma and skin metastases: a rare entity. 38
18408396 2008
15
Small cell carcinoma of the prostate. A morphologic and immunohistochemical study of 95 cases. 38
18162772 2008
16
Submandibular area metastasis from prostate small cell carcinoma with neuroendocrine differentiation. 38
17912103 2007
17
Extrapulmonary small cell carcinoma of the bladder. 38
17270661 2007
18
[Prostate small cell carcinoma: report of two cases that differed in treatment responsiveness]. 38
17176877 2006
19
[Small cell carcinoma of the prostate: an autopsy case report]. 38
16050480 2005
20
Metastatic pure small-cell carcinoma of prostate. 38
15545846 2004
21
Molecular characterization of prostatic small-cell neuroendocrine carcinoma. 38
12640661 2003
22
Brain metastasis from prostate small cell carcinoma: not to be neglected. 38
12463494 2002
23
[Small cell (oat cell) carcinoma of the prostate. Presentation of a case and review of the literature]. 38
1324565 1992
24
Small cell carcinoma of prostate: effectiveness of hormonal versus chemotherapy. 38
1315995 1992
25
Small-cell carcinoma of prostate. 38
2538948 1989
26
Small cell carcinoma of prostate associated with myasthenic (Eaton-Lambert) syndrome. 38
2536972 1989
27
Small cell carcinoma of prostate. 38
2536204 1989
28
Small-cell carcinoma of prostate. Transient complete remission with chemotherapy. 38
2992147 1985

Variations for Prostate Small Cell Carcinoma

Cosmic variations for Prostate Small Cell Carcinoma:

9 (show top 50) (show all 122)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM4062730 ZFHX3 prostate,NS,carcinoma,small cell carcinoma c.709C>T p.R237* 16:72959437-72959437 12
2 COSM6921648 YAP1 prostate,NS,carcinoma,small cell carcinoma c.952C>T p.Q318* 11:102223703-102223703 12
3 COSM6921999 WT1 prostate,NS,carcinoma,small cell carcinoma c.322C>G p.R108G 11:32434820-32434820 12
4 COSM6921997 WT1 prostate,NS,carcinoma,small cell carcinoma c.340C>T p.P114S 11:32434802-32434802 12
5 COSM10662 TP53 prostate,NS,carcinoma,small cell carcinoma c.743G>A p.R248Q 17:7674220-7674220 12
6 COSM29760 TP53 prostate,NS,carcinoma,small cell carcinoma c.673-2A>C p.? 17:7674292-7674292 12
7 COSM44510 TP53 prostate,NS,carcinoma,small cell carcinoma c.717C>G p.N239K 17:7674246-7674246 12
8 COSM10889 TP53 prostate,NS,carcinoma,small cell carcinoma c.536A>G p.H179R 17:7675076-7675076 12
9 COSM10704 TP53 prostate,NS,carcinoma,small cell carcinoma c.844C>T p.R282W 17:7673776-7673776 12
10 COSM10648 TP53 prostate,NS,carcinoma,small cell carcinoma c.524G>A p.R175H 17:7675088-7675088 12
11 COSM44682 TP53 prostate,NS,carcinoma,small cell carcinoma c.568C>T p.P190S 17:7674963-7674963 12
12 COSM6916401 SUFU prostate,NS,carcinoma,small cell carcinoma c.196G>T p.D66Y 10:102509182-102509182 12
13 COSM6929784 STAT5B prostate,NS,carcinoma,small cell carcinoma c.319C>T p.R107C 17:42224835-42224835 12
14 COSM219965 SPOP prostate,NS,carcinoma,small cell carcinoma c.397T>G p.F133V 17:49619064-49619064 12
15 COSM6921641 SMO prostate,NS,carcinoma,small cell carcinoma c.1754A>C p.Q585P 7:129211066-129211066 12
16 COSM5621806 SETD2 prostate,NS,carcinoma,small cell carcinoma c.4039C>T p.R1347C 3:47084232-47084232 12
17 COSM899738 SDHB prostate,NS,carcinoma,small cell carcinoma c.688C>T p.R230C 1:17022685-17022685 12
18 COSM6916403 RPS6KA4 prostate,NS,carcinoma,small cell carcinoma c.860C>T p.A287V 11:64361956-64361956 12
19 COSM6913288 RB1 prostate,NS,carcinoma,small cell carcinoma c.1814+1G>T p.? 13:48453112-48453112 12
20 COSM938 RB1 prostate,NS,carcinoma,small cell carcinoma c.967G>T p.E323* 13:48367521-48367521 12
21 COSM6929781 POLE prostate,NS,carcinoma,small cell carcinoma c.2264T>C p.V755A 12:132667558-132667558 12
22 COSM5760562 PIK3R1 prostate,NS,carcinoma,small cell carcinoma c.1746-1G>A p.? 5:68295419-68295419 12
23 COSM6921639 PIK3R1 prostate,NS,carcinoma,small cell carcinoma c.469A>C p.N157H 5:68273980-68273980 12
24 COSM6926748 PIK3CD prostate,NS,carcinoma,small cell carcinoma c.2608C>T p.R870* 1:9723982-9723982 12
25 COSM1220603 PIK3CD prostate,NS,carcinoma,small cell carcinoma c.113G>A p.R38H 1:9710568-9710568 12
26 COSM6916392 PIK3CD prostate,NS,carcinoma,small cell carcinoma c.2681G>A p.R894Q 1:9724055-9724055 12
27 COSM86046 PIK3CA prostate,NS,carcinoma,small cell carcinoma c.316G>C p.G106R 3:179199141-179199141 12
28 COSM6947213 PARP1 prostate,NS,carcinoma,small cell carcinoma c.770C>G p.S257* 1:226386390-226386390 12
29 COSM6929778 NSD1 prostate,NS,carcinoma,small cell carcinoma c.5816G>A p.R1939H 5:177280758-177280758 12
30 COSM6947255 NOTCH2 prostate,NS,carcinoma,small cell carcinoma c.3779G>A p.R1260H 1:119929089-119929089 12
31 COSM6918331 NOTCH1 prostate,NS,carcinoma,small cell carcinoma c.4659G>C p.E1553D 9:136505032-136505032 12
32 COSM3961569 NFE2L2 prostate,NS,carcinoma,small cell carcinoma c.1390C>G p.L464V 2:177231213-177231213 12
33 COSM6918329 MSH2 prostate,NS,carcinoma,small cell carcinoma c.907G>C p.D303H 2:47414383-47414383 12
34 COSM6916405 KMT2A prostate,NS,carcinoma,small cell carcinoma c.11357G>A p.R3786H 11:118520001-118520001 12
35 COSM6922000 IRS2 prostate,NS,carcinoma,small cell carcinoma c.3366G>C p.Q1122H 13:109782688-109782688 12
36 COSM6960356 IRS2 prostate,NS,carcinoma,small cell carcinoma c.553G>T p.G185W 13:109785501-109785501 12
37 COSM496 HRAS prostate,NS,carcinoma,small cell carcinoma c.181C>A p.Q61K 11:533875-533875 12
38 COSM227099 H3-5 prostate,NS,carcinoma,small cell carcinoma c.289G>A p.E97K 12:31791878-31791878 12
39 COSM6918334 GRIN2A prostate,NS,carcinoma,small cell carcinoma c.3662T>C p.M1221T 16:9763882-9763882 12
40 COSM332280 GRIN2A prostate,NS,carcinoma,small cell carcinoma c.3506G>A p.R1169Q 16:9764038-9764038 12
41 COSM6940832 FOXP1 prostate,NS,carcinoma,small cell carcinoma c.1708A>T p.N570Y 3:70970750-70970750 12
42 COSM3738526 FOXA1 prostate,NS,carcinoma,small cell carcinoma c.655C>A p.R219S 14:37592129-37592129 12
43 COSM6947218 FOXA1 prostate,NS,carcinoma,small cell carcinoma c.511C>T p.P171S 14:37592273-37592273 12
44 COSM6908932 FLT4 prostate,NS,carcinoma,small cell carcinoma c.81G>T p.M27I 5:180631756-180631756 12
45 COSM6916397 FGFR4 prostate,NS,carcinoma,small cell carcinoma c.310C>T p.R104* 5:177090608-177090608 12
46 COSM6916407 ERBB2 prostate,NS,carcinoma,small cell carcinoma c.1318G>A p.A440T 17:39715744-39715744 12
47 COSM6921995 EPHB1 prostate,NS,carcinoma,small cell carcinoma c.758G>T p.C253F 3:134952005-134952005 12
48 COSM6947215 EPHB1 prostate,NS,carcinoma,small cell carcinoma c.1601A>C p.E534A 3:135165983-135165983 12
49 COSM6930618 EPHA5 prostate,NS,carcinoma,small cell carcinoma c.2726A>T p.Q909L 4:65336058-65336058 12
50 COSM6921640 EGFR prostate,NS,carcinoma,small cell carcinoma c.2279T>C p.L760P 7:55174816-55174816 12

Expression for Prostate Small Cell Carcinoma

Search GEO for disease gene expression data for Prostate Small Cell Carcinoma.

Pathways for Prostate Small Cell Carcinoma

GO Terms for Prostate Small Cell Carcinoma

Biological processes related to Prostate Small Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.76 PTEN NKX2-1 KIT GATA3
2 negative regulation of apoptotic process GO:0043066 9.72 PTEN AURKA ASCL1
3 T cell differentiation GO:0030217 9.57 KIT GATA3
4 cell maturation GO:0048469 9.56 GATA3 ASCL1
5 regulation of neuron projection development GO:0010975 9.54 PTEN GATA3
6 neuron migration GO:0001764 9.54 NKX2-1 GATA3 ASCL1
7 oligodendrocyte differentiation GO:0048709 9.52 NKX2-1 ASCL1
8 neuron fate commitment GO:0048663 9.51 NKX2-1 ASCL1
9 negative regulation of epithelial to mesenchymal transition GO:0010719 9.49 PTEN NKX2-1
10 anatomical structure formation involved in morphogenesis GO:0048646 9.48 NKX2-1 GATA3
11 sympathetic nervous system development GO:0048485 9.43 GATA3 ASCL1
12 embryonic hemopoiesis GO:0035162 9.4 KIT GATA3
13 cell activation GO:0001775 9.32 GATA3 CD24
14 forebrain neuron differentiation GO:0021879 9.26 NKX2-1 ASCL1
15 regulation of epithelial cell differentiation GO:0030856 9.16 CD24 ASCL1
16 cerebral cortex GABAergic interneuron differentiation GO:0021892 8.96 NKX2-1 ASCL1
17 mast cell differentiation GO:0060374 8.62 KIT GATA3

Sources for Prostate Small Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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