MCID: PRS008
MIFTS: 29

Prostate Small Cell Carcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Prostate Small Cell Carcinoma

MalaCards integrated aliases for Prostate Small Cell Carcinoma:

Name: Prostate Small Cell Carcinoma 12 15
Small Cell Carcinoma of Prostate 12 73
Prostate Oat Cell Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7141
NCIt 50 C6766
UMLS 73 C1300585

Summaries for Prostate Small Cell Carcinoma

MalaCards based summary : Prostate Small Cell Carcinoma, also known as small cell carcinoma of prostate, is related to small cell carcinoma and carotid body cancer. An important gene associated with Prostate Small Cell Carcinoma is SYP (Synaptophysin). The drugs Olaparib and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include prostate, lung and colon, and related phenotypes are Decreased viability in esophageal squamous lineage and growth/size/body region

Related Diseases for Prostate Small Cell Carcinoma

Diseases related to Prostate Small Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 145)
# Related Disease Score Top Affiliating Genes
1 small cell carcinoma 30.1 ENO2 KIT KLK3 NKX2-1 PTEN SYP
2 carotid body cancer 10.3 ENO2 SYP
3 malignant sertoli cell tumor 10.3 ENO2 SYP
4 urinary bladder small cell neuroendocrine carcinoma 10.3 ENO2 SYP
5 auditory system cancer 10.3 ENO2 SYP
6 sinonasal undifferentiated carcinoma 10.3 ENO2 SYP
7 gallbladder small cell carcinoma 10.3 ENO2 SYP
8 pancreatic somatostatinoma 10.3 ENO2 SYP
9 extrahepatic bile duct adenocarcinoma 10.3 ENO2 SYP
10 papillary tumor of the pineal region 10.3 ENO2 SYP
11 sensory organ benign neoplasm 10.3 ENO2 SYP
12 orbital cancer 10.3 ENO2 SYP
13 middle ear adenoma 10.3 ENO2 SYP
14 pulmonary large cell neuroendocrine carcinoma 10.3 ENO2 SYP
15 atypical follicular adenoma 10.3 ENO2 SYP
16 central nervous system primitive neuroectodermal neoplasm 10.3 ENO2 SYP
17 cerebellum cancer 10.3 ENO2 SYP
18 clear cell ependymoma 10.3 ENO2 SYP
19 cerebral neuroblastoma 10.3 ENO2 SYP
20 cauda equina neoplasm 10.3 ENO2 SYP
21 extraosseous chondrosarcoma 10.3 ENO2 SYP
22 subependymal glioma 10.3 ENO2 SYP
23 malignant teratoma 10.3 ENO2 SYP
24 astroblastoma 10.3 ENO2 SYP
25 cerebral ventricle cancer 10.3 ENO2 SYP
26 olfactory nerve neoplasm 10.3 ENO2 SYP
27 pineal gland cancer 10.2 ENO2 SYP
28 autonomic nervous system benign neoplasm 10.2 ENO2 SYP
29 melanotic neuroectodermal tumor 10.2 ENO2 SYP
30 benign ependymoma 10.2 ENO2 SYP
31 nodular ganglioneuroblastoma 10.2 ENO2 SYP
32 ganglioneuroblastoma 10.2 ENO2 SYP
33 pineocytoma 10.2 ENO2 SYP
34 rhabdoid cancer 10.2 ENO2 SYP
35 cervical clear cell adenocarcinoma 10.2 ENO2 SYP
36 gastric small cell carcinoma 10.2 ENO2 SYP
37 desmoplastic small round cell tumor 10.2 ENO2 SYP
38 subependymoma 10.2 ENO2 SYP
39 mucinous ovarian cystadenoma 10.2 ENO2 SYP
40 male reproductive organ benign neoplasm 10.2 KLK3 SYP
41 bone benign neoplasm 10.2 ENO2 SYP
42 benign glioma 10.2 ENO2 SYP
43 gastric squamous cell carcinoma 10.2 ENO2 SYP
44 meningeal melanomatosis 10.2 ENO2 SYP
45 seminal vesicle tumor 10.2 KLK3 SYP
46 papillary ependymoma 10.2 ENO2 SYP
47 connective tissue benign neoplasm 10.2 ENO2 SYP
48 glomus tumor 10.2 ENO2 SYP
49 intraocular retinoblastoma 10.2 ENO2 SYP
50 central neurocytoma 10.2 ENO2 SYP

Graphical network of the top 20 diseases related to Prostate Small Cell Carcinoma:



Diseases related to Prostate Small Cell Carcinoma

Symptoms & Phenotypes for Prostate Small Cell Carcinoma

GenomeRNAi Phenotypes related to Prostate Small Cell Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.23 ASCL1 AURKA KIT KLK3 NKX2-1 PTEN

MGI Mouse Phenotypes related to Prostate Small Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.56 AMACR ASCL1 AURKA ENO2 KIT NKX2-1
2 taste/olfaction MP:0005394 8.8 ASCL1 ENO2 PTEN

Drugs & Therapeutics for Prostate Small Cell Carcinoma

Drugs for Prostate Small Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Olaparib Approved Phase 2 763113-22-0 23725625
2
Carboplatin Approved Phase 1, Phase 2 41575-94-4 10339178 38904 498142
3
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
4
Cortisone acetate Approved, Investigational Phase 2 1950-04-4, 50-04-4 5745
5
Cediranib Investigational Phase 2 288383-20-0 9933475
6
Cortisone Experimental Phase 2 53-06-5 222786
7 Poly(ADP-ribose) Polymerase Inhibitors Phase 2
8 Protein Kinase Inhibitors Phase 2
9 taxane Phase 1, Phase 2
10 Cytochrome P-450 Enzyme Inhibitors Phase 2
11 Antineoplastic Agents, Hormonal Phase 2
12 Anti-Inflammatory Agents Phase 2
13 Androgen Antagonists Phase 2
14 glucocorticoids Phase 2
15 Hormone Antagonists Phase 2
16 Steroid Synthesis Inhibitors Phase 2
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
18
Abiraterone acetate Phase 2 154229-18-2 57336518
19 Hormones Phase 2
20 Androgens Phase 2
21
Pembrolizumab Approved Phase 1 1374853-91-4
22
Etoposide Approved Phase 1 33419-42-0 36462
23
Cisplatin Approved Phase 1 15663-27-1 2767 441203 84093
24
Docetaxel Approved, Investigational Phase 1 114977-28-5 148124
25 Keratolytic Agents Phase 1
26 Topoisomerase Inhibitors Phase 1
27 Antineoplastic Agents, Phytogenic Phase 1
28 Podophyllotoxin Phase 1 518-28-5
29 Antimitotic Agents Phase 1
30 Etoposide phosphate Phase 1
31 Dermatologic Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Olaparib With or Without Cediranib in Treating Patients With Metastatic Castration-Resistant Prostate Cancer Recruiting NCT02893917 Phase 2 Cediranib;Olaparib
2 Cabazitaxel With or Without Carboplatin in Treating Patients With Previously Treated Metastatic Castration-Resistant Prostate Cancer Active, not recruiting NCT01505868 Phase 1, Phase 2 Cabazitaxel;Carboplatin
3 Effects of Antiandrogen Therapy, Abiraterone Acetate, and Prednisone With or Without Radiation on Prostate Cancer Not yet recruiting NCT03649841 Phase 2 Antiandrogen Therapy;Abiraterone Acetate;Prednisone
4 Pembrolizumab With Combination Chemotherapy in Treating Participants With Locally Advanced or Metastatic Small Cell/Neuroendocrine Cancers of Urothelium or Prostate Not yet recruiting NCT03582475 Phase 1 Carboplatin;Cisplatin;Docetaxel;Etoposide

Search NIH Clinical Center for Prostate Small Cell Carcinoma

Genetic Tests for Prostate Small Cell Carcinoma

Anatomical Context for Prostate Small Cell Carcinoma

MalaCards organs/tissues related to Prostate Small Cell Carcinoma:

41
Prostate, Lung, Colon, Heart, Testis, Thymus, Pineal

Publications for Prostate Small Cell Carcinoma

Articles related to Prostate Small Cell Carcinoma:

# Title Authors Year
1
Small Cell Carcinoma of Prostate: A Case Report of a Patient With Concomitant Transitional Cell Cancer of the Bladder. ( 29536021 )
2018
2
Pure Small Cell Carcinoma of Prostate: A Report of 8 Cases. ( 30269133 )
2018
3
Primary small cell carcinoma of prostate without immunoreactive neuroendocrine proteins but with expressions of KIT and platelet-derived growth factor-I+ ( 25195713 )
2014
4
Prostate small cell carcinoma and skin metastases: a rare entity. ( 18408396 )
2008
5
Submandibular area metastasis from prostate small cell carcinoma with neuroendocrine differentiation. ( 17912103 )
2007
6
Brain metastasis from prostate small cell carcinoma: not to be neglected. ( 12463494 )
2002
7
Small cell carcinoma of prostate associated with myasthenic (Eaton-Lambert) syndrome. ( 2536972 )
1989

Variations for Prostate Small Cell Carcinoma

Cosmic variations for Prostate Small Cell Carcinoma:

9 (show top 50) (show all 122)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM4062730 ZFHX3 prostate,NS,carcinoma,small cell carcinoma c.709C>T p.R237* 16:72959437-72959437 11
2 COSM6921648 YAP1 prostate,NS,carcinoma,small cell carcinoma c.952C>T p.Q318* 11:102223703-102223703 11
3 COSM6921999 WT1 prostate,NS,carcinoma,small cell carcinoma c.322C>G p.R108G 11:32434820-32434820 11
4 COSM6921997 WT1 prostate,NS,carcinoma,small cell carcinoma c.340C>T p.P114S 11:32434802-32434802 11
5 COSM44510 TP53 prostate,NS,carcinoma,small cell carcinoma c.717C>G p.N239K 17:7674246-7674246 11
6 COSM10889 TP53 prostate,NS,carcinoma,small cell carcinoma c.536A>G p.H179R 17:7675076-7675076 11
7 COSM10662 TP53 prostate,NS,carcinoma,small cell carcinoma c.743G>A p.R248Q 17:7674220-7674220 11
8 COSM29760 TP53 prostate,NS,carcinoma,small cell carcinoma c.673-2A>C p.? 17:7674292-7674292 11
9 COSM10648 TP53 prostate,NS,carcinoma,small cell carcinoma c.524G>A p.R175H 17:7675088-7675088 11
10 COSM10704 TP53 prostate,NS,carcinoma,small cell carcinoma c.844C>T p.R282W 17:7673776-7673776 11
11 COSM44682 TP53 prostate,NS,carcinoma,small cell carcinoma c.568C>T p.P190S 17:7674963-7674963 11
12 COSM6916401 SUFU prostate,NS,carcinoma,small cell carcinoma c.196G>T p.D66Y 10:102509182-102509182 11
13 COSM6929784 STAT5B prostate,NS,carcinoma,small cell carcinoma c.319C>T p.R107C 17:42224835-42224835 11
14 COSM219965 SPOP prostate,NS,carcinoma,small cell carcinoma c.397T>G p.F133V 17:49619064-49619064 11
15 COSM6921641 SMO prostate,NS,carcinoma,small cell carcinoma c.1754A>C p.Q585P 7:129211066-129211066 11
16 COSM5621806 SETD2 prostate,NS,carcinoma,small cell carcinoma c.4039C>T p.R1347C 3:47084232-47084232 11
17 COSM899738 SDHB prostate,NS,carcinoma,small cell carcinoma c.688C>T p.R230C 1:17022685-17022685 11
18 COSM6916403 RPS6KA4 prostate,NS,carcinoma,small cell carcinoma c.860C>T p.A287V 11:64361956-64361956 11
19 COSM6913288 RB1 prostate,NS,carcinoma,small cell carcinoma c.1814+1G>T p.? 13:48453112-48453112 11
20 COSM938 RB1 prostate,NS,carcinoma,small cell carcinoma c.967G>T p.E323* 13:48367521-48367521 11
21 COSM6929781 POLE prostate,NS,carcinoma,small cell carcinoma c.2264T>C p.V755A 12:132667558-132667558 11
22 COSM6921639 PIK3R1 prostate,NS,carcinoma,small cell carcinoma c.469A>C p.N157H 5:68273980-68273980 11
23 COSM5760562 PIK3R1 prostate,NS,carcinoma,small cell carcinoma c.1746-1G>A p.? 5:68295419-68295419 11
24 COSM6926748 PIK3CD prostate,NS,carcinoma,small cell carcinoma c.2608C>T p.R870* 1:9723982-9723982 11
25 COSM1220603 PIK3CD prostate,NS,carcinoma,small cell carcinoma c.113G>A p.R38H 1:9710568-9710568 11
26 COSM6916392 PIK3CD prostate,NS,carcinoma,small cell carcinoma c.2681G>A p.R894Q 1:9724055-9724055 11
27 COSM86046 PIK3CA prostate,NS,carcinoma,small cell carcinoma c.316G>C p.G106R 3:179199141-179199141 11
28 COSM6947213 PARP1 prostate,NS,carcinoma,small cell carcinoma c.770C>G p.S257* 1:226386390-226386390 11
29 COSM6929778 NSD1 prostate,NS,carcinoma,small cell carcinoma c.5816G>A p.R1939H 5:177280758-177280758 11
30 COSM6947255 NOTCH2 prostate,NS,carcinoma,small cell carcinoma c.3779G>A p.R1260H 1:119929089-119929089 11
31 COSM6918331 NOTCH1 prostate,NS,carcinoma,small cell carcinoma c.4659G>C p.E1553D 9:136505032-136505032 11
32 COSM3961569 NFE2L2 prostate,NS,carcinoma,small cell carcinoma c.1390C>G p.L464V 2:177231213-177231213 11
33 COSM6918329 MSH2 prostate,NS,carcinoma,small cell carcinoma c.907G>C p.D303H 2:47414383-47414383 11
34 COSM6916405 KMT2A prostate,NS,carcinoma,small cell carcinoma c.11357G>A p.R3786H 11:118520001-118520001 11
35 COSM6922000 IRS2 prostate,NS,carcinoma,small cell carcinoma c.3366G>C p.Q1122H 13:109782688-109782688 11
36 COSM6960356 IRS2 prostate,NS,carcinoma,small cell carcinoma c.553G>T p.G185W 13:109785501-109785501 11
37 COSM496 HRAS prostate,NS,carcinoma,small cell carcinoma c.181C>A p.Q61K 11:533875-533875 11
38 COSM227099 H3F3C prostate,NS,carcinoma,small cell carcinoma c.289G>A p.E97K 12:31791878-31791878 11
39 COSM6918334 GRIN2A prostate,NS,carcinoma,small cell carcinoma c.3662T>C p.M1221T 16:9763882-9763882 11
40 COSM332280 GRIN2A prostate,NS,carcinoma,small cell carcinoma c.3506G>A p.R1169Q 16:9764038-9764038 11
41 COSM6940832 FOXP1 prostate,NS,carcinoma,small cell carcinoma c.1708A>T p.N570Y 3:70970750-70970750 11
42 COSM3738526 FOXA1 prostate,NS,carcinoma,small cell carcinoma c.655C>A p.R219S 14:37592129-37592129 11
43 COSM6947218 FOXA1 prostate,NS,carcinoma,small cell carcinoma c.511C>T p.P171S 14:37592273-37592273 11
44 COSM6908932 FLT4 prostate,NS,carcinoma,small cell carcinoma c.81G>T p.M27I 5:180631756-180631756 11
45 COSM6916397 FGFR4 prostate,NS,carcinoma,small cell carcinoma c.310C>T p.R104* 5:177090608-177090608 11
46 COSM6916407 ERBB2 prostate,NS,carcinoma,small cell carcinoma c.1318G>A p.A440T 17:39715744-39715744 11
47 COSM6921995 EPHB1 prostate,NS,carcinoma,small cell carcinoma c.758G>T p.C253F 3:134952005-134952005 11
48 COSM6947215 EPHB1 prostate,NS,carcinoma,small cell carcinoma c.1601A>C p.E534A 3:135165983-135165983 11
49 COSM6930618 EPHA5 prostate,NS,carcinoma,small cell carcinoma c.2726A>T p.Q909L 4:65336058-65336058 11
50 COSM6921640 EGFR prostate,NS,carcinoma,small cell carcinoma c.2279T>C p.L760P 7:55174816-55174816 11

Expression for Prostate Small Cell Carcinoma

Search GEO for disease gene expression data for Prostate Small Cell Carcinoma.

Pathways for Prostate Small Cell Carcinoma

GO Terms for Prostate Small Cell Carcinoma

Biological processes related to Prostate Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.67 ASCL1 AURKA KIT PTEN
2 oligodendrocyte differentiation GO:0048709 9.32 ASCL1 NKX2-1
3 neuron fate commitment GO:0048663 9.26 ASCL1 NKX2-1
4 negative regulation of epithelial to mesenchymal transition GO:0010719 9.16 NKX2-1 PTEN
5 forebrain neuron differentiation GO:0021879 8.96 ASCL1 NKX2-1
6 cerebral cortex GABAergic interneuron differentiation GO:0021892 8.62 ASCL1 NKX2-1

Sources for Prostate Small Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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