Prostate Small Cell Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: PRS008 MIFTS: 29	Prostate Small Cell Carcinoma Categories: Cancer diseases, Reproductive diseases
Genes Variations Tissues Related diseases Publications Drugs Expand all tables

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Aliases & Classifications for Prostate Small Cell Carcinoma

MalaCards integrated aliases for Prostate Small Cell Carcinoma:

Name: Prostate Small Cell Carcinoma ¹² ¹⁵

Small Cell Carcinoma of Prostate ¹² ⁷³

Prostate Oat Cell Carcinoma ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:7141

NCIt ⁵⁰ C6766

UMLS ⁷³ C1300585

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Summaries for Prostate Small Cell Carcinoma

MalaCards based summary : Prostate Small Cell Carcinoma, also known as small cell carcinoma of prostate, is related to small cell carcinoma and carotid body cancer. An important gene associated with Prostate Small Cell Carcinoma is SYP (Synaptophysin). The drugs Olaparib and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include prostate, lung and colon, and related phenotypes are Decreased viability in esophageal squamous lineage and growth/size/body region

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Related Diseases for Prostate Small Cell Carcinoma

Diseases related to Prostate Small Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 145)

#	Related Disease	Score	Top Affiliating Genes
1	small cell carcinoma	30.1	ENO2 KIT KLK3 NKX2-1 PTEN SYP
2	carotid body cancer	10.3	ENO2 SYP
3	malignant sertoli cell tumor	10.3	ENO2 SYP
4	urinary bladder small cell neuroendocrine carcinoma	10.3	ENO2 SYP
5	auditory system cancer	10.3	ENO2 SYP
6	sinonasal undifferentiated carcinoma	10.3	ENO2 SYP
7	gallbladder small cell carcinoma	10.3	ENO2 SYP
8	pancreatic somatostatinoma	10.3	ENO2 SYP
9	extrahepatic bile duct adenocarcinoma	10.3	ENO2 SYP
10	papillary tumor of the pineal region	10.3	ENO2 SYP
11	sensory organ benign neoplasm	10.3	ENO2 SYP
12	orbital cancer	10.3	ENO2 SYP
13	middle ear adenoma	10.3	ENO2 SYP
14	pulmonary large cell neuroendocrine carcinoma	10.3	ENO2 SYP
15	atypical follicular adenoma	10.3	ENO2 SYP
16	central nervous system primitive neuroectodermal neoplasm	10.3	ENO2 SYP
17	cerebellum cancer	10.3	ENO2 SYP
18	clear cell ependymoma	10.3	ENO2 SYP
19	cerebral neuroblastoma	10.3	ENO2 SYP
20	cauda equina neoplasm	10.3	ENO2 SYP
21	extraosseous chondrosarcoma	10.3	ENO2 SYP
22	subependymal glioma	10.3	ENO2 SYP
23	malignant teratoma	10.3	ENO2 SYP
24	astroblastoma	10.3	ENO2 SYP
25	cerebral ventricle cancer	10.3	ENO2 SYP
26	olfactory nerve neoplasm	10.3	ENO2 SYP
27	pineal gland cancer	10.2	ENO2 SYP
28	autonomic nervous system benign neoplasm	10.2	ENO2 SYP
29	melanotic neuroectodermal tumor	10.2	ENO2 SYP
30	benign ependymoma	10.2	ENO2 SYP
31	nodular ganglioneuroblastoma	10.2	ENO2 SYP
32	ganglioneuroblastoma	10.2	ENO2 SYP
33	pineocytoma	10.2	ENO2 SYP
34	rhabdoid cancer	10.2	ENO2 SYP
35	cervical clear cell adenocarcinoma	10.2	ENO2 SYP
36	gastric small cell carcinoma	10.2	ENO2 SYP
37	desmoplastic small round cell tumor	10.2	ENO2 SYP
38	subependymoma	10.2	ENO2 SYP
39	mucinous ovarian cystadenoma	10.2	ENO2 SYP
40	male reproductive organ benign neoplasm	10.2	KLK3 SYP
41	bone benign neoplasm	10.2	ENO2 SYP
42	benign glioma	10.2	ENO2 SYP
43	gastric squamous cell carcinoma	10.2	ENO2 SYP
44	meningeal melanomatosis	10.2	ENO2 SYP
45	seminal vesicle tumor	10.2	KLK3 SYP
46	papillary ependymoma	10.2	ENO2 SYP
47	connective tissue benign neoplasm	10.2	ENO2 SYP
48	glomus tumor	10.2	ENO2 SYP
49	intraocular retinoblastoma	10.2	ENO2 SYP
50	central neurocytoma	10.2	ENO2 SYP

Graphical network of the top 20 diseases related to Prostate Small Cell Carcinoma:

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Symptoms & Phenotypes for Prostate Small Cell Carcinoma

GenomeRNAi Phenotypes related to Prostate Small Cell Carcinoma according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability in esophageal squamous lineage	GR00235-A	9.23	ASCL1 AURKA KIT KLK3 NKX2-1 PTEN

MGI Mouse Phenotypes related to Prostate Small Cell Carcinoma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size/body region	MP:0005378	9.56	AMACR ASCL1 AURKA ENO2 KIT NKX2-1
2	taste/olfaction	MP:0005394	8.8	ASCL1 ENO2 PTEN

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Drugs & Therapeutics for Prostate Small Cell Carcinoma

Drugs for Prostate Small Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Olaparib

Approved

Phase 2

763113-22-0

23725625

Carboplatin

Approved

Phase 1, Phase 2

41575-94-4

10339178 38904 498142

Prednisone

Approved, Vet_approved

Phase 2

53-03-2

5865

Cortisone acetate

Approved, Investigational

Phase 2

1950-04-4, 50-04-4

5745

Cediranib

Investigational

Phase 2

288383-20-0

9933475

Cortisone

Experimental

Phase 2

53-06-5

222786

Poly(ADP-ribose) Polymerase Inhibitors

Phase 2

Protein Kinase Inhibitors

Phase 2

taxane

Phase 1, Phase 2

Cytochrome P-450 Enzyme Inhibitors

Phase 2

Antineoplastic Agents, Hormonal

Phase 2

Anti-Inflammatory Agents

Phase 2

Androgen Antagonists

Phase 2

glucocorticoids

Phase 2

Hormone Antagonists

Phase 2

Steroid Synthesis Inhibitors

Phase 2

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 2

Abiraterone acetate

Phase 2

154229-18-2

57336518

Hormones

Phase 2

Androgens

Phase 2

Pembrolizumab

Approved

Phase 1

1374853-91-4

Etoposide

Approved

Phase 1

33419-42-0

36462

Cisplatin

Approved

Phase 1

15663-27-1

2767 441203 84093

Docetaxel

Approved, Investigational

Phase 1

114977-28-5

148124

Keratolytic Agents

Phase 1

Topoisomerase Inhibitors

Phase 1

Antineoplastic Agents, Phytogenic

Phase 1

Podophyllotoxin

Phase 1

518-28-5

Antimitotic Agents

Phase 1

Etoposide phosphate

Phase 1

Dermatologic Agents

Phase 1

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Olaparib With or Without Cediranib in Treating Patients With Metastatic Castration-Resistant Prostate Cancer	Recruiting	NCT02893917	Phase 2	Cediranib;Olaparib
2	Cabazitaxel With or Without Carboplatin in Treating Patients With Previously Treated Metastatic Castration-Resistant Prostate Cancer	Active, not recruiting	NCT01505868	Phase 1, Phase 2	Cabazitaxel;Carboplatin
3	Effects of Antiandrogen Therapy, Abiraterone Acetate, and Prednisone With or Without Radiation on Prostate Cancer	Not yet recruiting	NCT03649841	Phase 2	Antiandrogen Therapy;Abiraterone Acetate;Prednisone
4	Pembrolizumab With Combination Chemotherapy in Treating Participants With Locally Advanced or Metastatic Small Cell/Neuroendocrine Cancers of Urothelium or Prostate	Not yet recruiting	NCT03582475	Phase 1	Carboplatin;Cisplatin;Docetaxel;Etoposide

Search NIH Clinical Center for Prostate Small Cell Carcinoma

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Genetic Tests for Prostate Small Cell Carcinoma

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Anatomical Context for Prostate Small Cell Carcinoma

MalaCards organs/tissues related to Prostate Small Cell Carcinoma:

⁴¹

Prostate, Lung, Colon, Heart, Testis, Thymus, Pineal

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Publications for Prostate Small Cell Carcinoma

Articles related to Prostate Small Cell Carcinoma:

#	Title	Authors	Year
1	Small Cell Carcinoma of Prostate: A Case Report of a Patient With Concomitant Transitional Cell Cancer of the Bladder. ( 29536021 )	Abusnina W...Pacioles T	2018
2	Pure Small Cell Carcinoma of Prostate: A Report of 8 Cases. ( 30269133 )	Zhang Y...Ye Z	2018
3	Primary small cell carcinoma of prostate without immunoreactive neuroendocrine proteins but with expressions of KIT and platelet-derived growth factor-I+ ( 25195713 )		2014
4	Prostate small cell carcinoma and skin metastases: a rare entity. ( 18408396 )	Yildirim Y....Celasun B.	2008
5	Submandibular area metastasis from prostate small cell carcinoma with neuroendocrine differentiation. ( 17912103 )	Xiao W.L....Li N.Y.	2007
6	Brain metastasis from prostate small cell carcinoma: not to be neglected. ( 12463494 )	Erasmus C.E....van Lindert E.J.	2002
7	Small cell carcinoma of prostate associated with myasthenic (Eaton-Lambert) syndrome. ( 2536972 )		1989

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Genes for Prostate Small Cell Carcinoma

Genes related to Prostate Small Cell Carcinoma (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SYP	Synaptophysin	Protein Coding	16.54	GeneCards inferred via : Publications (show sections)
2	SV2B	Synaptic Vesicle Glycoprotein 2B	Protein Coding	16.5	DISEASES inferred ¹⁵
3	ASCL1	Achaete-Scute Family BHLH Transcription Factor 1	Protein Coding	14.9	DISEASES inferred ¹⁵
4	ENO2	Enolase 2	Protein Coding	14.79	DISEASES inferred ¹⁵
5	FOLH1	Folate Hydrolase 1	Protein Coding	14.68	DISEASES inferred ¹⁵
6	KLK3	Kallikrein Related Peptidase 3	Protein Coding	14.58	DISEASES inferred ¹⁵
7	AURKA	Aurora Kinase A	Protein Coding	14.16	DISEASES inferred ¹⁵
8	NKX2-1	NK2 Homeobox 1	Protein Coding	13.96	DISEASES inferred ¹⁵
9	KIT	KIT Proto-Oncogene Receptor Tyrosine Kinase	Protein Coding	13.13	DISEASES inferred ¹⁵
10	PTEN	Phosphatase And Tensin Homolog	Protein Coding	13.04	DISEASES inferred ¹⁵
11	AMACR	Alpha-Methylacyl-CoA Racemase	Protein Coding	12.95	DISEASES inferred ¹⁵
12	SLC45A3	Solute Carrier Family 45 Member 3	Protein Coding	5.56	DISEASES inferred ¹⁵

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Variations for Prostate Small Cell Carcinoma

Cosmic variations for Prostate Small Cell Carcinoma:

⁹ (show top 50) (show all 122)

#	Cosmic Mut ID	Gene Symbol	COSMIC Disease Classification (Primary site, Site subtype, Primary histology, Histology subtype)	Mutation CDS	Mutation AA	GRCh38 Location	Conf
1	COSM4062730	ZFHX3	prostate,NS,carcinoma,small cell carcinoma	c.709C>T	p.R237*	16:72959437-72959437	11
2	COSM6921648	YAP1	prostate,NS,carcinoma,small cell carcinoma	c.952C>T	p.Q318*	11:102223703-102223703	11
3	COSM6921999	WT1	prostate,NS,carcinoma,small cell carcinoma	c.322C>G	p.R108G	11:32434820-32434820	11
4	COSM6921997	WT1	prostate,NS,carcinoma,small cell carcinoma	c.340C>T	p.P114S	11:32434802-32434802	11
5	COSM44510	TP53	prostate,NS,carcinoma,small cell carcinoma	c.717C>G	p.N239K	17:7674246-7674246	11
6	COSM10889	TP53	prostate,NS,carcinoma,small cell carcinoma	c.536A>G	p.H179R	17:7675076-7675076	11
7	COSM10662	TP53	prostate,NS,carcinoma,small cell carcinoma	c.743G>A	p.R248Q	17:7674220-7674220	11
8	COSM29760	TP53	prostate,NS,carcinoma,small cell carcinoma	c.673-2A>C	p.?	17:7674292-7674292	11
9	COSM10648	TP53	prostate,NS,carcinoma,small cell carcinoma	c.524G>A	p.R175H	17:7675088-7675088	11
10	COSM10704	TP53	prostate,NS,carcinoma,small cell carcinoma	c.844C>T	p.R282W	17:7673776-7673776	11
11	COSM44682	TP53	prostate,NS,carcinoma,small cell carcinoma	c.568C>T	p.P190S	17:7674963-7674963	11
12	COSM6916401	SUFU	prostate,NS,carcinoma,small cell carcinoma	c.196G>T	p.D66Y	10:102509182-102509182	11
13	COSM6929784	STAT5B	prostate,NS,carcinoma,small cell carcinoma	c.319C>T	p.R107C	17:42224835-42224835	11
14	COSM219965	SPOP	prostate,NS,carcinoma,small cell carcinoma	c.397T>G	p.F133V	17:49619064-49619064	11
15	COSM6921641	SMO	prostate,NS,carcinoma,small cell carcinoma	c.1754A>C	p.Q585P	7:129211066-129211066	11
16	COSM5621806	SETD2	prostate,NS,carcinoma,small cell carcinoma	c.4039C>T	p.R1347C	3:47084232-47084232	11
17	COSM899738	SDHB	prostate,NS,carcinoma,small cell carcinoma	c.688C>T	p.R230C	1:17022685-17022685	11
18	COSM6916403	RPS6KA4	prostate,NS,carcinoma,small cell carcinoma	c.860C>T	p.A287V	11:64361956-64361956	11
19	COSM6913288	RB1	prostate,NS,carcinoma,small cell carcinoma	c.1814+1G>T	p.?	13:48453112-48453112	11
20	COSM938	RB1	prostate,NS,carcinoma,small cell carcinoma	c.967G>T	p.E323*	13:48367521-48367521	11
21	COSM6929781	POLE	prostate,NS,carcinoma,small cell carcinoma	c.2264T>C	p.V755A	12:132667558-132667558	11
22	COSM6921639	PIK3R1	prostate,NS,carcinoma,small cell carcinoma	c.469A>C	p.N157H	5:68273980-68273980	11
23	COSM5760562	PIK3R1	prostate,NS,carcinoma,small cell carcinoma	c.1746-1G>A	p.?	5:68295419-68295419	11
24	COSM6926748	PIK3CD	prostate,NS,carcinoma,small cell carcinoma	c.2608C>T	p.R870*	1:9723982-9723982	11
25	COSM1220603	PIK3CD	prostate,NS,carcinoma,small cell carcinoma	c.113G>A	p.R38H	1:9710568-9710568	11
26	COSM6916392	PIK3CD	prostate,NS,carcinoma,small cell carcinoma	c.2681G>A	p.R894Q	1:9724055-9724055	11
27	COSM86046	PIK3CA	prostate,NS,carcinoma,small cell carcinoma	c.316G>C	p.G106R	3:179199141-179199141	11
28	COSM6947213	PARP1	prostate,NS,carcinoma,small cell carcinoma	c.770C>G	p.S257*	1:226386390-226386390	11
29	COSM6929778	NSD1	prostate,NS,carcinoma,small cell carcinoma	c.5816G>A	p.R1939H	5:177280758-177280758	11
30	COSM6947255	NOTCH2	prostate,NS,carcinoma,small cell carcinoma	c.3779G>A	p.R1260H	1:119929089-119929089	11
31	COSM6918331	NOTCH1	prostate,NS,carcinoma,small cell carcinoma	c.4659G>C	p.E1553D	9:136505032-136505032	11
32	COSM3961569	NFE2L2	prostate,NS,carcinoma,small cell carcinoma	c.1390C>G	p.L464V	2:177231213-177231213	11
33	COSM6918329	MSH2	prostate,NS,carcinoma,small cell carcinoma	c.907G>C	p.D303H	2:47414383-47414383	11
34	COSM6916405	KMT2A	prostate,NS,carcinoma,small cell carcinoma	c.11357G>A	p.R3786H	11:118520001-118520001	11
35	COSM6922000	IRS2	prostate,NS,carcinoma,small cell carcinoma	c.3366G>C	p.Q1122H	13:109782688-109782688	11
36	COSM6960356	IRS2	prostate,NS,carcinoma,small cell carcinoma	c.553G>T	p.G185W	13:109785501-109785501	11
37	COSM496	HRAS	prostate,NS,carcinoma,small cell carcinoma	c.181C>A	p.Q61K	11:533875-533875	11
38	COSM227099	H3F3C	prostate,NS,carcinoma,small cell carcinoma	c.289G>A	p.E97K	12:31791878-31791878	11
39	COSM6918334	GRIN2A	prostate,NS,carcinoma,small cell carcinoma	c.3662T>C	p.M1221T	16:9763882-9763882	11
40	COSM332280	GRIN2A	prostate,NS,carcinoma,small cell carcinoma	c.3506G>A	p.R1169Q	16:9764038-9764038	11
41	COSM6940832	FOXP1	prostate,NS,carcinoma,small cell carcinoma	c.1708A>T	p.N570Y	3:70970750-70970750	11
42	COSM3738526	FOXA1	prostate,NS,carcinoma,small cell carcinoma	c.655C>A	p.R219S	14:37592129-37592129	11
43	COSM6947218	FOXA1	prostate,NS,carcinoma,small cell carcinoma	c.511C>T	p.P171S	14:37592273-37592273	11
44	COSM6908932	FLT4	prostate,NS,carcinoma,small cell carcinoma	c.81G>T	p.M27I	5:180631756-180631756	11
45	COSM6916397	FGFR4	prostate,NS,carcinoma,small cell carcinoma	c.310C>T	p.R104*	5:177090608-177090608	11
46	COSM6916407	ERBB2	prostate,NS,carcinoma,small cell carcinoma	c.1318G>A	p.A440T	17:39715744-39715744	11
47	COSM6921995	EPHB1	prostate,NS,carcinoma,small cell carcinoma	c.758G>T	p.C253F	3:134952005-134952005	11
48	COSM6947215	EPHB1	prostate,NS,carcinoma,small cell carcinoma	c.1601A>C	p.E534A	3:135165983-135165983	11
49	COSM6930618	EPHA5	prostate,NS,carcinoma,small cell carcinoma	c.2726A>T	p.Q909L	4:65336058-65336058	11
50	COSM6921640	EGFR	prostate,NS,carcinoma,small cell carcinoma	c.2279T>C	p.L760P	7:55174816-55174816	11

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Expression for Prostate Small Cell Carcinoma

Search GEO for disease gene expression data for Prostate Small Cell Carcinoma.

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Pathways for Prostate Small Cell Carcinoma

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GO Terms for Prostate Small Cell Carcinoma

Biological processes related to Prostate Small Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of apoptotic process	GO:0043066	9.67	ASCL1 AURKA KIT PTEN
2	oligodendrocyte differentiation	GO:0048709	9.32	ASCL1 NKX2-1
3	neuron fate commitment	GO:0048663	9.26	ASCL1 NKX2-1
4	negative regulation of epithelial to mesenchymal transition	GO:0010719	9.16	NKX2-1 PTEN
5	forebrain neuron differentiation	GO:0021879	8.96	ASCL1 NKX2-1
6	cerebral cortex GABAergic interneuron differentiation	GO:0021892	8.62	ASCL1 NKX2-1

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Sources for Prostate Small Cell Carcinoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia