MCID: PRS008
MIFTS: 32

Prostate Small Cell Carcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Prostate Small Cell Carcinoma

MalaCards integrated aliases for Prostate Small Cell Carcinoma:

Name: Prostate Small Cell Carcinoma 12 15 17
Small Cell Carcinoma of Prostate 12 74
Prostate Oat Cell Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7141
NCIt 51 C6766
UMLS 74 C1300585

Summaries for Prostate Small Cell Carcinoma

MalaCards based summary : Prostate Small Cell Carcinoma, also known as small cell carcinoma of prostate, is related to small cell carcinoma and small cell carcinoma of the bladder. An important gene associated with Prostate Small Cell Carcinoma is SV2B (Synaptic Vesicle Glycoprotein 2B). The drugs nivolumab and Ipilimumab have been mentioned in the context of this disorder. Affiliated tissues include testis, skin and brain, and related phenotypes are Decreased viability in esophageal squamous lineage and respiratory system

Related Diseases for Prostate Small Cell Carcinoma

Diseases related to Prostate Small Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 small cell carcinoma 29.7 ENO2 KIT KLK3 NKX2-1 PTEN
2 small cell carcinoma of the bladder 10.2 ENO2 NKX2-1
3 villous adenoma 10.2 FOLH1 KLK3
4 prostatic hyperplasia, benign 10.2 FOLH1 KLK3
5 carcinoid tumors, intestinal 10.2 ENO2 NKX2-1
6 respiratory system benign neoplasm 10.2 ENO2 NKX2-1
7 extraskeletal ewing sarcoma 10.2 ENO2 NKX2-1
8 cystic teratoma 10.2 ENO2 NKX2-1
9 subependymal giant cell astrocytoma 10.2 ENO2 NKX2-1
10 horseshoe kidney 10.2 ENO2 NKX2-1
11 adenocarcinoma 10.2
12 cutaneous ganglioneuroma 10.1 ENO2 KIT
13 maxillary sinus adenoid cystic carcinoma 10.1 FOLH1 KIT
14 gastric leiomyosarcoma 10.1 ENO2 KIT
15 plexiform schwannoma 10.1 ENO2 KIT
16 conventional fibrosarcoma 10.1 ENO2 KIT
17 endometrial small cell carcinoma 10.1 ENO2 KIT
18 prostate embryonal rhabdomyosarcoma 10.1 KIT KLK3
19 angiomyoma 10.1 ENO2 KIT
20 heart sarcoma 10.1 ENO2 KIT
21 prostate rhabdomyosarcoma 10.1 KIT KLK3
22 nodular prostate 10.1 ENO2 FOLH1 KLK3
23 lung benign neoplasm 10.1 ENO2 NKX2-1
24 neuroendocrine tumor 10.1 ASCL1 ENO2 NKX2-1
25 mixed cell type cancer 10.1 ENO2 KIT
26 dysgerminoma of ovary 10.1 ENO2 KIT
27 prostatic acinar adenocarcinoma 10.1 KIT KLK3
28 dysgerminoma 10.1 ENO2 KIT
29 lung adenoid cystic carcinoma 10.0 KIT NKX2-1
30 lung oat cell carcinoma 10.0
31 central nervous system melanocytic neoplasm 10.0 ENO2 KIT
32 muscle cancer 10.0 ENO2 KIT
33 pachyonychia congenita 3 10.0
34 connective tissue cancer 10.0 ENO2 KIT
35 neurilemmoma 10.0 ENO2 KIT
36 achalasia 9.9 ENO2 KIT
37 hyperinsulinemic hypoglycemia, familial, 3 9.9 AURKA PTEN
38 merkel cell carcinoma 9.9 ENO2 KIT NKX2-1
39 teratoma 9.9 ENO2 KIT NKX2-1
40 lambert syndrome 9.9
41 ovarian melanoma 9.9 KIT PTEN
42 mixed type thymoma 9.8 KIT PTEN
43 clear cell sarcoma 9.8 ENO2 KIT
44 cavernous hemangioma 9.8 KIT NKX2-1
45 reproductive system disease 9.8 FOLH1 KLK3 PTEN
46 prostate disease 9.8 FOLH1 KLK3 PTEN
47 respiratory system cancer 9.8 ENO2 NKX2-1 PTEN
48 hemangioma 9.8 ENO2 NKX2-1 PTEN
49 large cell neuroendocrine carcinoma 9.7 ASCL1 ENO2 KIT NKX2-1
50 rete testis adenocarcinoma 9.7 ENO2 KIT KLK3 NKX2-1

Graphical network of the top 20 diseases related to Prostate Small Cell Carcinoma:



Diseases related to Prostate Small Cell Carcinoma

Symptoms & Phenotypes for Prostate Small Cell Carcinoma

GenomeRNAi Phenotypes related to Prostate Small Cell Carcinoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.23 ASCL1 AURKA KIT KLK3 NKX2-1 PTEN

MGI Mouse Phenotypes related to Prostate Small Cell Carcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 respiratory system MP:0005388 9.35 ASCL1 ENO2 KIT NKX2-1 PTEN
2 taste/olfaction MP:0005394 8.8 ASCL1 ENO2 PTEN

Drugs & Therapeutics for Prostate Small Cell Carcinoma

Drugs for Prostate Small Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2 946414-94-4
2
Ipilimumab Approved Phase 2 477202-00-9
3
Carboplatin Approved Phase 1, Phase 2 41575-94-4 10339178 38904 498142
4
Olaparib Approved Phase 2 763113-22-0 23725625
5
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
6
Topotecan Approved, Investigational Phase 2 119413-54-6, 123948-87-8 60700
7
Cediranib Investigational Phase 2 288383-20-0 9933475
8
Cortisone Experimental Phase 2 53-06-5 222786
9 Antibodies Phase 2
10 Antineoplastic Agents, Immunological Phase 2,Phase 1
11 Antibodies, Monoclonal Phase 2
12 Immunoglobulins Phase 2
13 Topoisomerase Inhibitors Phase 2,Phase 1
14 Poly(ADP-ribose) Polymerase Inhibitors Phase 2
15 Protein Kinase Inhibitors Phase 2
16 taxane Phase 1, Phase 2
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
18 Hormone Antagonists Phase 2
19 Cytochrome P-450 Enzyme Inhibitors Phase 2
20 Steroid Synthesis Inhibitors Phase 2
21 Hormones Phase 2
22
Abiraterone acetate Phase 2 154229-18-2 57336518
23 Androgen Antagonists Phase 2
24 glucocorticoids Phase 2
25 Antineoplastic Agents, Hormonal Phase 2
26 Anti-Inflammatory Agents Phase 2
27 Androgens Phase 2
28 topoisomerase I inhibitors Phase 2
29
Etoposide Approved Phase 1 33419-42-0 36462
30
Pembrolizumab Approved Phase 1 1374853-91-4
31
Cisplatin Approved Phase 1 15663-27-1 2767 441203 84093
32
Docetaxel Approved, Investigational Phase 1 114977-28-5 148124
33 Keratolytic Agents Phase 1
34 Antimitotic Agents Phase 1
35 Podophyllotoxin Phase 1 518-28-5
36 Dermatologic Agents Phase 1
37 Etoposide phosphate Phase 1
38 Antineoplastic Agents, Phytogenic Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cabozantinib in Combination With Nivolumab and Ipilimumab in Rare Genitourinary Tumors Recruiting NCT03866382 Phase 2 Cabozantinib;Cabozantinib S-malate
2 Olaparib With or Without Cediranib in Treating Patients With Metastatic Castration-Resistant Prostate Cancer Active, not recruiting NCT02893917 Phase 2 Cediranib;Olaparib
3 Cabazitaxel With or Without Carboplatin in Treating Patients With Previously Treated Metastatic Castration-Resistant Prostate Cancer Active, not recruiting NCT01505868 Phase 1, Phase 2 Cabazitaxel;Carboplatin
4 Effects of Antiandrogen Therapy, Abiraterone Acetate, and Prednisone With or Without Radiation on Prostate Cancer Not yet recruiting NCT03649841 Phase 2 Antiandrogen Therapy;Abiraterone Acetate;Prednisone
5 Topotecan Hydrochloride With or Without M6620 in Treating Patients With Relapsed Small Cell Lung Cancer or Extrapulmonary Small Cell Cancer Not yet recruiting NCT03896503 Phase 2 ATR Kinase Inhibitor M6620;Topotecan;Topotecan Hydrochloride
6 Pembrolizumab With Combination Chemotherapy in Treating Participants With Locally Advanced or Metastatic Small Cell/Neuroendocrine Cancers of Urothelium or Prostate Recruiting NCT03582475 Phase 1 Carboplatin;Cisplatin;Docetaxel;Etoposide

Search NIH Clinical Center for Prostate Small Cell Carcinoma

Genetic Tests for Prostate Small Cell Carcinoma

Anatomical Context for Prostate Small Cell Carcinoma

MalaCards organs/tissues related to Prostate Small Cell Carcinoma:

42
Testis, Skin, Brain, Kidney, Ovary

Publications for Prostate Small Cell Carcinoma

Articles related to Prostate Small Cell Carcinoma:

# Title Authors Year
1
Molecular analysis and literature-based hypothesis of an immunonegative prostate small cell carcinoma causing ectopic ACTH syndrome. ( 30918166 )
2019
2
Prostate small cell carcinoma and skin metastases: a rare entity. ( 18408396 )
2008
3
Submandibular area metastasis from prostate small cell carcinoma with neuroendocrine differentiation. ( 17912103 )
2007
4
Brain metastasis from prostate small cell carcinoma: not to be neglected. ( 12463494 )
2002

Variations for Prostate Small Cell Carcinoma

Cosmic variations for Prostate Small Cell Carcinoma:

9 (show top 50) (show all 122)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM4062730 ZFHX3 prostate,NS,carcinoma,small cell carcinoma c.709C>T p.R237* 16:72959437-72959437 0
2 COSM6921648 YAP1 prostate,NS,carcinoma,small cell carcinoma c.952C>T p.Q318* 11:102223703-102223703 0
3 COSM6921999 WT1 prostate,NS,carcinoma,small cell carcinoma c.322C>G p.R108G 11:32434820-32434820 0
4 COSM6921997 WT1 prostate,NS,carcinoma,small cell carcinoma c.340C>T p.P114S 11:32434802-32434802 0
5 COSM10662 TP53 prostate,NS,carcinoma,small cell carcinoma c.743G>A p.R248Q 17:7674220-7674220 0
6 COSM29760 TP53 prostate,NS,carcinoma,small cell carcinoma c.673-2A>C p.? 17:7674292-7674292 0
7 COSM44510 TP53 prostate,NS,carcinoma,small cell carcinoma c.717C>G p.N239K 17:7674246-7674246 0
8 COSM10889 TP53 prostate,NS,carcinoma,small cell carcinoma c.536A>G p.H179R 17:7675076-7675076 0
9 COSM10704 TP53 prostate,NS,carcinoma,small cell carcinoma c.844C>T p.R282W 17:7673776-7673776 0
10 COSM10648 TP53 prostate,NS,carcinoma,small cell carcinoma c.524G>A p.R175H 17:7675088-7675088 0
11 COSM44682 TP53 prostate,NS,carcinoma,small cell carcinoma c.568C>T p.P190S 17:7674963-7674963 0
12 COSM6916401 SUFU prostate,NS,carcinoma,small cell carcinoma c.196G>T p.D66Y 10:102509182-102509182 0
13 COSM6929784 STAT5B prostate,NS,carcinoma,small cell carcinoma c.319C>T p.R107C 17:42224835-42224835 0
14 COSM219965 SPOP prostate,NS,carcinoma,small cell carcinoma c.397T>G p.F133V 17:49619064-49619064 0
15 COSM6921641 SMO prostate,NS,carcinoma,small cell carcinoma c.1754A>C p.Q585P 7:129211066-129211066 0
16 COSM5621806 SETD2 prostate,NS,carcinoma,small cell carcinoma c.4039C>T p.R1347C 3:47084232-47084232 0
17 COSM899738 SDHB prostate,NS,carcinoma,small cell carcinoma c.688C>T p.R230C 1:17022685-17022685 0
18 COSM6916403 RPS6KA4 prostate,NS,carcinoma,small cell carcinoma c.860C>T p.A287V 11:64361956-64361956 0
19 COSM6913288 RB1 prostate,NS,carcinoma,small cell carcinoma c.1814+1G>T p.? 13:48453112-48453112 0
20 COSM938 RB1 prostate,NS,carcinoma,small cell carcinoma c.967G>T p.E323* 13:48367521-48367521 0
21 COSM6929781 POLE prostate,NS,carcinoma,small cell carcinoma c.2264T>C p.V755A 12:132667558-132667558 0
22 COSM5760562 PIK3R1 prostate,NS,carcinoma,small cell carcinoma c.1746-1G>A p.? 5:68295419-68295419 0
23 COSM6921639 PIK3R1 prostate,NS,carcinoma,small cell carcinoma c.469A>C p.N157H 5:68273980-68273980 0
24 COSM6926748 PIK3CD prostate,NS,carcinoma,small cell carcinoma c.2608C>T p.R870* 1:9723982-9723982 0
25 COSM1220603 PIK3CD prostate,NS,carcinoma,small cell carcinoma c.113G>A p.R38H 1:9710568-9710568 0
26 COSM6916392 PIK3CD prostate,NS,carcinoma,small cell carcinoma c.2681G>A p.R894Q 1:9724055-9724055 0
27 COSM86046 PIK3CA prostate,NS,carcinoma,small cell carcinoma c.316G>C p.G106R 3:179199141-179199141 0
28 COSM6947213 PARP1 prostate,NS,carcinoma,small cell carcinoma c.770C>G p.S257* 1:226386390-226386390 0
29 COSM6929778 NSD1 prostate,NS,carcinoma,small cell carcinoma c.5816G>A p.R1939H 5:177280758-177280758 0
30 COSM6947255 NOTCH2 prostate,NS,carcinoma,small cell carcinoma c.3779G>A p.R1260H 1:119929089-119929089 0
31 COSM6918331 NOTCH1 prostate,NS,carcinoma,small cell carcinoma c.4659G>C p.E1553D 9:136505032-136505032 0
32 COSM3961569 NFE2L2 prostate,NS,carcinoma,small cell carcinoma c.1390C>G p.L464V 2:177231213-177231213 0
33 COSM6918329 MSH2 prostate,NS,carcinoma,small cell carcinoma c.907G>C p.D303H 2:47414383-47414383 0
34 COSM6916405 KMT2A prostate,NS,carcinoma,small cell carcinoma c.11357G>A p.R3786H 11:118520001-118520001 0
35 COSM6922000 IRS2 prostate,NS,carcinoma,small cell carcinoma c.3366G>C p.Q1122H 13:109782688-109782688 0
36 COSM6960356 IRS2 prostate,NS,carcinoma,small cell carcinoma c.553G>T p.G185W 13:109785501-109785501 0
37 COSM496 HRAS prostate,NS,carcinoma,small cell carcinoma c.181C>A p.Q61K 11:533875-533875 0
38 COSM227099 H3F3C prostate,NS,carcinoma,small cell carcinoma c.289G>A p.E97K 12:31791878-31791878 0
39 COSM6918334 GRIN2A prostate,NS,carcinoma,small cell carcinoma c.3662T>C p.M1221T 16:9763882-9763882 0
40 COSM332280 GRIN2A prostate,NS,carcinoma,small cell carcinoma c.3506G>A p.R1169Q 16:9764038-9764038 0
41 COSM6940832 FOXP1 prostate,NS,carcinoma,small cell carcinoma c.1708A>T p.N570Y 3:70970750-70970750 0
42 COSM3738526 FOXA1 prostate,NS,carcinoma,small cell carcinoma c.655C>A p.R219S 14:37592129-37592129 0
43 COSM6947218 FOXA1 prostate,NS,carcinoma,small cell carcinoma c.511C>T p.P171S 14:37592273-37592273 0
44 COSM6908932 FLT4 prostate,NS,carcinoma,small cell carcinoma c.81G>T p.M27I 5:180631756-180631756 0
45 COSM6916397 FGFR4 prostate,NS,carcinoma,small cell carcinoma c.310C>T p.R104* 5:177090608-177090608 0
46 COSM6916407 ERBB2 prostate,NS,carcinoma,small cell carcinoma c.1318G>A p.A440T 17:39715744-39715744 0
47 COSM6921995 EPHB1 prostate,NS,carcinoma,small cell carcinoma c.758G>T p.C253F 3:134952005-134952005 0
48 COSM6947215 EPHB1 prostate,NS,carcinoma,small cell carcinoma c.1601A>C p.E534A 3:135165983-135165983 0
49 COSM6930618 EPHA5 prostate,NS,carcinoma,small cell carcinoma c.2726A>T p.Q909L 4:65336058-65336058 0
50 COSM6921640 EGFR prostate,NS,carcinoma,small cell carcinoma c.2279T>C p.L760P 7:55174816-55174816 0

Expression for Prostate Small Cell Carcinoma

Search GEO for disease gene expression data for Prostate Small Cell Carcinoma.

Pathways for Prostate Small Cell Carcinoma

GO Terms for Prostate Small Cell Carcinoma

Biological processes related to Prostate Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.54 ASCL1 AURKA PTEN
2 oligodendrocyte differentiation GO:0048709 9.4 ASCL1 NKX2-1
3 neuron fate commitment GO:0048663 9.32 ASCL1 NKX2-1
4 negative regulation of epithelial to mesenchymal transition GO:0010719 9.26 NKX2-1 PTEN
5 forebrain neuron differentiation GO:0021879 9.16 ASCL1 NKX2-1
6 regulation of epithelial cell differentiation GO:0030856 8.96 ASCL1 CD24
7 cerebral cortex GABAergic interneuron differentiation GO:0021892 8.62 ASCL1 NKX2-1

Sources for Prostate Small Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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