MCID: PRS004
MIFTS: 32

Prostate Squamous Cell Carcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Prostate Squamous Cell Carcinoma

MalaCards integrated aliases for Prostate Squamous Cell Carcinoma:

Name: Prostate Squamous Cell Carcinoma 12 15
Squamous Cell Carcinoma of Prostate 12 73
Squamous Cell Carcinoma of the Prostate 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10287
NCIt 50 C5536
UMLS 73 C1302530

Summaries for Prostate Squamous Cell Carcinoma

Disease Ontology : 12 A squamous cell carcinoma that is located in the prostate.

MalaCards based summary : Prostate Squamous Cell Carcinoma, also known as squamous cell carcinoma of prostate, is related to ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 and uterine corpus cancer. An important gene associated with Prostate Squamous Cell Carcinoma is PPP2R1A (Protein Phosphatase 2 Scaffold Subunit Aalpha), and among its related pathways/superpathways are Cellular senescence (KEGG) and Hepatitis C. Affiliated tissues include prostate, lung and liver, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Prostate Squamous Cell Carcinoma

Diseases related to Prostate Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 200)
# Related Disease Score Top Affiliating Genes
1 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 10.3 PPP2R1A TP53
2 uterine corpus cancer 10.3 PPP2R1A TP53
3 villous adenoma 10.2 KLK3 KRT8
4 breast benign neoplasm 10.2 KRT5 TP53
5 thoracic benign neoplasm 10.2 KRT5 TP53
6 secondary hypertrophic osteoarthropathy 10.2 HRAS SMUG1
7 submandibular gland cancer 10.2 KLK3 TP53
8 mature teratoma 10.2 SMUG1 TP53
9 central nervous system hematologic cancer 10.2 SMUG1 TP53
10 cervical clear cell adenocarcinoma 10.2 KRT5 KRT8
11 atrophy of prostate 10.2 KLK3 TP53
12 sarcomatoid squamous cell skin carcinoma 10.2 KRT5 KRT8
13 odontoma 10.2 KRT5 KRT8
14 fetal adenoma 10.2 CEACAM5 HRAS
15 uterine corpus serous adenocarcinoma 10.2 PPP2R1A TP53
16 calcifying epithelial odontogenic tumor 10.2 KRT8 TP53
17 pleural cancer 10.2 KRT5 SMUG1
18 rete testis neoplasm 10.2 CEACAM5 KLK3
19 benign struma ovarii 10.2 HRAS SMUG1
20 sigmoid neoplasm 10.2 CEACAM5 HRAS
21 serous cystadenocarcinoma 10.2 HRAS PPP2R1A TP53
22 prostatic cyst 10.2 KLK3 SMUG1
23 bartholin's duct cyst 10.2 SMUG1 TP53
24 anal canal adenocarcinoma 10.2 HRAS KRT7
25 keratinizing squamous cell carcinoma 10.2 KRT5 TP53
26 cellular ependymoma 10.2 SMUG1 TP53
27 protoplasmic astrocytoma 10.2 SMUG1 TP53
28 apocrine adenoma 10.2 CEACAM5 HRAS
29 colloid adenoma 10.2 SMUG1 TP53
30 prostate signet ring cell adenocarcinoma 10.2 CEACAM5 KLK3
31 prostate lymphoma 10.2 KLK3 SMUG1
32 spitz nevus 10.2 HRAS LRRC56 TP53
33 endocervical adenocarcinoma 10.2 KRT7 TP53
34 appendix cancer 10.2 KRT7 TP53
35 cystic teratoma 10.2 KRT7 TP53
36 glycogen-rich clear cell breast carcinoma 10.2 KRT7 TP53
37 female urethral cancer 10.2 CEACAM5 KLK3
38 prostate adenoid cystic carcinoma 10.2 HRAS KLK3 LRRC56
39 spiradenoma 10.2 KRT7 TP53
40 intracranial chondrosarcoma 10.1 CEACAM5 TP53
41 prostatic acinar adenocarcinoma 10.1 KLK3 KRT7
42 seminal vesicle tumor 10.1 KLK3 KRT7
43 descending colon cancer 10.1 CEACAM5 SMUG1
44 urethral diverticulum 10.1 KLK3 KRT7
45 pericardial tuberculosis 10.1 CEACAM5 SMUG1
46 tuberculous peritonitis 10.1 CEACAM5 SMUG1
47 immune system organ benign neoplasm 10.1 KRT7 KRT8
48 thymus lipoma 10.1 KRT7 KRT8
49 mucinous tubular and spindle renal cell carcinoma 10.1 KRT7 KRT8
50 uterine body mixed cancer 10.1 PPP2R1A TP53

Graphical network of the top 20 diseases related to Prostate Squamous Cell Carcinoma:



Diseases related to Prostate Squamous Cell Carcinoma

Symptoms & Phenotypes for Prostate Squamous Cell Carcinoma

GenomeRNAi Phenotypes related to Prostate Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.44 KRT5
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.44 KRT5
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.44 KRT5 KRT8
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.44 KRT5
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.44 KRT8
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.44 KRT7
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.44 KRT5 KRT7 KRT8
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.44 KRT7
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.44 KRT5 KRT7

MGI Mouse Phenotypes related to Prostate Squamous Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.02 B2M HRAS PPP2R1A SMUG1 TP53

Drugs & Therapeutics for Prostate Squamous Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Prostate Squamous Cell Carcinoma

Genetic Tests for Prostate Squamous Cell Carcinoma

Anatomical Context for Prostate Squamous Cell Carcinoma

MalaCards organs/tissues related to Prostate Squamous Cell Carcinoma:

41
Prostate, Lung, Liver, Colon, Ovary, Testis, Thymus

The Foundational Model of Anatomy Ontology organs/tissues related to Prostate Squamous Cell Carcinoma:

19
The Prostate

Publications for Prostate Squamous Cell Carcinoma

Articles related to Prostate Squamous Cell Carcinoma:

# Title Authors Year
1
Primary squamous cell carcinoma of the prostate. ( 11020062 )
2000
2
Schistosomiasis, metaplasia and squamous cell carcinoma of the prostate: histogenesis of the squamous cancer cells determined by localization of specific markers. ( 2415839 )
1985

Variations for Prostate Squamous Cell Carcinoma

Expression for Prostate Squamous Cell Carcinoma

Search GEO for disease gene expression data for Prostate Squamous Cell Carcinoma.

Pathways for Prostate Squamous Cell Carcinoma

Pathways related to Prostate Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.64 HLA-A HRAS TP53
2 11.45 HRAS PPP2R1A TP53
3 11.2 HRAS PPP2R1A TP53
4
Show member pathways
10.83 KRT5 KRT7 KRT8
5 10.72 B2M HLA-A

GO Terms for Prostate Squamous Cell Carcinoma

Cellular components related to Prostate Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 9.43 KRT5 KRT7 KRT8
2 keratin filament GO:0045095 9.33 KRT5 KRT7 KRT8
3 extracellular exosome GO:0070062 9.23 B2M CEACAM5 HLA-A KLK3 KRT5 KRT7
4 MHC class I protein complex GO:0042612 8.96 B2M HLA-A

Biological processes related to Prostate Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.4 B2M HLA-A
2 cell aging GO:0007569 9.37 HRAS TP53
3 cellular response to gamma radiation GO:0071480 9.32 HRAS TP53
4 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.26 B2M HLA-A
5 positive regulation of T cell mediated cytotoxicity GO:0001916 9.16 B2M HLA-A
6 cornification GO:0070268 9.13 KRT5 KRT7 KRT8
7 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 8.62 B2M HLA-A

Sources for Prostate Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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