MCID: PRS004
MIFTS: 32

Prostate Squamous Cell Carcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Prostate Squamous Cell Carcinoma

MalaCards integrated aliases for Prostate Squamous Cell Carcinoma:

Name: Prostate Squamous Cell Carcinoma 12 15
Squamous Cell Carcinoma of Prostate 70

Classifications:



External Ids:

Disease Ontology 12 DOID:10287
NCIt 50 C5536
SNOMED-CT 67 399590005
UMLS 70 C1302530

Summaries for Prostate Squamous Cell Carcinoma

Disease Ontology : 12 A squamous cell carcinoma that is located in the prostate.

MalaCards based summary : Prostate Squamous Cell Carcinoma, also known as squamous cell carcinoma of prostate, is related to squamous cell carcinoma and adenocarcinoma. An important gene associated with Prostate Squamous Cell Carcinoma is PIK3CA (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha), and among its related pathways/superpathways are Cellular Senescence (REACTOME) and PI3K-Akt signaling pathway. Affiliated tissues include prostate, and related phenotypes are cellular and mortality/aging

Related Diseases for Prostate Squamous Cell Carcinoma

Diseases related to Prostate Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 143)
# Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 30.5 TP53 PIK3CA MAP2K1 HRAS CDKN2A
2 adenocarcinoma 30.4 TP53 PIK3CA MAP2K1 HRAS CDKN2A
3 suppression of tumorigenicity 12 30.2 TP53 PIK3CA MAP2K1 LRRC56 HRAS CDKN2A
4 pancreatic signet ring cell adenocarcinoma 10.4 TP53 HRAS
5 trachea carcinoma in situ 10.4 HRAS CDKN2A
6 splenic diffuse red pulp small b-cell lymphoma 10.4 TP53 MAP2K1
7 vulvar intraepithelial neoplasia 10.4 TP53 CDKN2A
8 esophagus verrucous carcinoma 10.4 TP53 CDKN2A
9 ovarian seromucinous carcinoma 10.4 TP53 CDKN2A
10 human papillomavirus infectious disease 10.4 TP53 CDKN2A
11 bone giant cell sarcoma 10.3 TP53 HRAS
12 adenosquamous lung carcinoma 10.3 PIK3CA HRAS
13 cystadenocarcinoma 10.3 TP53 PIK3CA HRAS
14 acneiform dermatitis 10.3 MAP2K1 HRAS
15 female reproductive endometrioid cancer 10.3 TP53 PIK3CA HRAS
16 penile benign neoplasm 10.3 TP53 PIK3CA CDKN2A
17 epithelial-myoepithelial carcinoma 10.3 TP53 PIK3CA HRAS
18 myoepithelial carcinoma 10.3 TP53 PIK3CA HRAS
19 uterine body mixed cancer 10.3 TP53 PIK3CA HRAS
20 malignant spiradenoma 10.3 TP53 PIK3CA CDKN2A
21 squamous cell papilloma 10.3 TP53 HRAS CDKN2A
22 vulva squamous cell carcinoma 10.3 TP53 PIK3CA CDKN2A
23 mixed cell type cancer 10.3 TP53 PIK3CA HRAS
24 acanthoma 10.3 TP53 PIK3CA CDKN2A
25 adult malignant schwannoma 10.3 TP53 HRAS CDKN2A
26 malignant exocrine pancreas neoplasm 10.3 TP53 HRAS CDKN2A
27 anal squamous cell carcinoma 10.3 TP53 PIK3CA CDKN2A
28 uterine corpus endometrial carcinoma 10.3 TP53 PIK3CA HRAS
29 rectum adenocarcinoma 10.3 TP53 PIK3CA HRAS
30 nasal cavity adenocarcinoma 10.3 TP53 HRAS CDKN2A
31 nasal cavity cancer 10.3 TP53 HRAS CDKN2A
32 endocervical carcinoma 10.3 TP53 PIK3CA CDKN2A
33 nodular malignant melanoma 10.3 TP53 HRAS CDKN2A
34 bizarre leiomyoma 10.3 TP53 CDKN2A
35 keratosis, seborrheic 10.3 TP53 PIK3CA CDKN2A
36 respiratory system benign neoplasm 10.3 TP53 HRAS CDKN2A
37 tonsil cancer 10.3 TP53 PIK3CA CDKN2A
38 endocervical adenocarcinoma 10.3 TP53 PIK3CA CDKN2A
39 schimmelpenning-feuerstein-mims syndrome 10.3 PIK3CA LRRC56 HRAS
40 reproductive organ benign neoplasm 10.3 TP53 HRAS CDKN2A
41 parameningeal embryonal rhabdomyosarcoma 10.3 TP53 PIK3CA
42 bilateral breast cancer 10.3 TP53 PIK3CA CDKN2A
43 large congenital melanocytic nevus 10.3 LRRC56 HRAS CDKN2A
44 nevus, epidermal 10.3 PIK3CA LRRC56 HRAS
45 lymphangioma 10.3 TP53 PIK3CA HRAS
46 supraglottis cancer 10.3 TP53 CDKN2A
47 lung benign neoplasm 10.3 TP53 HRAS CDKN2A
48 actinic keratosis 10.3 TP53 HRAS CDKN2A
49 biliary tract benign neoplasm 10.3 TP53 HRAS
50 adenosquamous carcinoma 10.2 TP53 PIK3CA CDKN2A

Graphical network of the top 20 diseases related to Prostate Squamous Cell Carcinoma:



Diseases related to Prostate Squamous Cell Carcinoma

Symptoms & Phenotypes for Prostate Squamous Cell Carcinoma

MGI Mouse Phenotypes related to Prostate Squamous Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.3 APTX CCNE1 CDK6 CDKN2A CHAF1A EPHB2
2 mortality/aging MP:0010768 10.28 ASF1A CCNE1 CDK6 CDKN2A CHAF1A ELF3
3 growth/size/body region MP:0005378 10.27 ASF1A CCNE1 CDK6 CDKN2A DNTT ELF3
4 embryo MP:0005380 10.25 ASF1A CCNE1 CDK6 CDKN2A CHAF1A HIRA
5 endocrine/exocrine gland MP:0005379 10.1 CCNE1 CDK6 CDKN2A EPHB2 GFI1 HNF4A
6 nervous system MP:0003631 9.97 ASF1A CCNE1 CDK6 CDKN2A EPHB2 GFI1
7 neoplasm MP:0002006 9.8 CCNE1 CDK6 CDKN2A HRAS MAP2K1 PIK3CA
8 skeleton MP:0005390 9.7 APTX CCNE1 CDKN2A DNTT HIRA HRAS
9 vision/eye MP:0005391 9.28 APTX CDK6 CDKN2A EPHB2 HNF4A MAP2K1

Drugs & Therapeutics for Prostate Squamous Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Prostate Squamous Cell Carcinoma

Genetic Tests for Prostate Squamous Cell Carcinoma

Anatomical Context for Prostate Squamous Cell Carcinoma

The Foundational Model of Anatomy Ontology organs/tissues related to Prostate Squamous Cell Carcinoma:

19
Prostate

MalaCards organs/tissues related to Prostate Squamous Cell Carcinoma:

40
Prostate

Publications for Prostate Squamous Cell Carcinoma

Articles related to Prostate Squamous Cell Carcinoma:

(show all 13)
# Title Authors PMID Year
1
Editorial Comment to Prostate squamous cell carcinoma developing 11 years after external radiotherapy for prostate adenocarcinoma. 61
33392468 2020
2
Prostate squamous cell carcinoma developing 11 years after external radiotherapy for prostate adenocarcinoma. 61
33392467 2020
3
Novel combination chemotherapy with radiotherapy for prostate squamous cell carcinoma. 61
31149464 2017
4
Fluorodeoxyglucose positron emission tomography/computed tomography imaging of a patient with squamous cell carcinoma of prostate. 61
24782898 2014
5
Matched rabbit monoclonal antibodies against αv-series integrins reveal a novel αvβ3-LIBS epitope, and permit routine staining of archival paraffin samples of human tumors. 61
23213423 2012
6
Vitamin D and differentiation in cancer. 61
19650715 2009
7
Polymorphic variation in hOGG1 and risk of cancer: a review of the functional and epidemiologic literature. 61
15584022 2005
8
Squamous cell carcinoma of the prostate--a case report. 61
16142562 2005
9
Squamous cell carcinoma of prostate. 61
2000687 1991
10
Hormone-independent polyamine metabolism of squamous cell carcinoma of the prostate. 61
3836020 1985
11
Studies on glutathione metabolism in ventral prostate and chemically induced prostatic carcinoma in rats. 61
6860782 1983
12
Squamous cell carcinoma of prostate. 61
7228098 1980
13
Squamous cell carcinoma of prostate. 61
14795561 1950

Variations for Prostate Squamous Cell Carcinoma

Expression for Prostate Squamous Cell Carcinoma

Search GEO for disease gene expression data for Prostate Squamous Cell Carcinoma.

Pathways for Prostate Squamous Cell Carcinoma

Pathways related to Prostate Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.12 TP53 SP1 HIRA CDKN2A CDK6 CCNE1
2
Show member pathways
12.98 TP53 PIK3CA MAP2K1 HRAS CDK6 CCNE1
3
Show member pathways
12.88 SP1 MAP2K1 HRAS CDKN2A CDK6 CCNE1
4
Show member pathways
12.88 TP53 SP1 PIK3CA MAP2K1 HRAS CDKN2A
5
Show member pathways
12.83 TP53 PIK3CA MAP2K1 CDK6 CCNE1
6
Show member pathways
12.79 TP53 PIK3CA MAP2K1 HRAS CDKN2A CDK6
7
Show member pathways
12.7 TP53 PIK3CA MAP2K1 HRAS CDKN2A
8 12.7 TP53 SP1 PIK3CA MAP2K1 HRAS CDKN2A
9
Show member pathways
12.6 TP53 SP1 PIK3CA MAP2K1 HRAS
10
Show member pathways
12.53 TP53 SP1 PIK3CA MAP2K1 HRAS CDKN2A
11 12.5 TP53 CDKN2A CDK6 CCNE1 APTX
12
Show member pathways
12.49 SP1 PIK3CA MAP2K1 HRAS
13
Show member pathways
12.46 TP53 PIK3CA MAP2K1 HRAS
14
Show member pathways
12.42 SP1 PIK3CA MAP2K1 HRAS
15
Show member pathways
12.41 SP1 PIK3CA MAP2K1 HRAS
16
Show member pathways
12.4 TP53 PIK3CA MAP2K1 HRAS
17
Show member pathways
12.39 TP53 CDKN2A CDK6 CCNE1
18 12.39 TP53 SP1 HNF4A CDK6 CCNE1
19 12.38 TP53 CDKN2A CDK6 CCNE1
20
Show member pathways
12.36 TP53 CDKN2A CDK6 CCNE1
21 12.36 SP1 SETDB1 SETD1A HIRA CHAF1A ASF1A
22 12.36 TP53 PIK3CA MAP2K1 HRAS CDKN2A CDK6
23
Show member pathways
12.36 TP53 SP1 PIK3CA MAP2K1 HRAS CDKN2A
24
Show member pathways
12.35 TP53 HIRA CCNE1 ASF1A
25
Show member pathways
12.33 TP53 PIK3CA MAP2K1 HRAS
26
Show member pathways
12.31 TP53 PIK3CA MAP2K1 HRAS
27 12.3 TP53 PIK3CA MAP2K1 HRAS
28 12.27 TP53 PIK3CA MAP2K1 HRAS CDKN2A CCNE1
29 12.23 PIK3CA MAP2K1 HRAS EPHB2
30
Show member pathways
12.22 SP1 CDKN2A CDK6 CCNE1
31 12.19 TP53 PIK3CA HRAS CDKN2A CDK6 CCNE1
32
Show member pathways
12.16 TP53 PIK3CA MAP2K1 HRAS
33 12.1 SETDB1 PIK3CA MAP2K1 HRAS
34 12.01 TP53 PIK3CA MAP2K1 HRAS
35 11.99 TP53 PIK3CA MAP2K1 HRAS
36 11.95 TP53 PIK3CA HRAS CDKN2A
37 11.91 TP53 MAP2K1 HRAS CDKN2A
38 11.85 TP53 CDK6 CCNE1
39 11.83 TP53 PIK3CA CDK6 CCNE1
40
Show member pathways
11.82 PIK3CA MAP2K1 HRAS
41 11.75 TP53 PIK3CA CDKN2A
42 11.74 SP1 MAP2K1 HRAS
43 11.74 PIK3CA MAP2K1 HRAS
44 11.71 TP53 SP1 HRAS
45 11.71 TP53 MAP2K1 HRAS CDKN2A
46
Show member pathways
11.7 SP1 PIK3CA CDK6
47 11.69 TP53 PIK3CA HRAS
48 11.67 PIK3CA MAP2K1 HRAS
49 11.67 TP53 PIK3CA MAP2K1 HRAS
50 11.65 SP1 GFI1 DNTT

GO Terms for Prostate Squamous Cell Carcinoma

Cellular components related to Prostate Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 10.09 TP53 SP1 SETDB1 SETD1A MAP2K1 HRAS
2 chromatin GO:0000785 9.65 TP53 SP1 SETD1A HNF4A HIRA GFI1
3 nucleoplasm GO:0005654 9.5 TP53 SP1 SETDB1 SETD1A HRAS HNF4A

Biological processes related to Prostate Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription, DNA-templated GO:0045892 9.85 TP53 HNF4A HIRA GFI1 ELF3 CDKN2A
2 positive regulation of gene expression GO:0010628 9.8 TP53 SP1 MAP2K1 HRAS EPHB2 CDKN2A
3 negative regulation of cell proliferation GO:0008285 9.63 TP53 MAP2K1 HRAS HNF4A CDKN2A CDK6
4 type B pancreatic cell development GO:0003323 9.46 HNF4A CDK6
5 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.43 TP53 MAP2K1
6 cellular senescence GO:0090398 9.43 MAP2K1 HRAS CDKN2A
7 chromatin assembly GO:0031497 9.4 TP53 CHAF1A
8 Ras protein signal transduction GO:0007265 9.26 TP53 SETDB1 HRAS CDKN2A
9 cell cycle arrest GO:0007050 9.02 TP53 MAP2K1 HRAS CDKN2A CDK6

Molecular functions related to Prostate Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.16 TP53 SP1 SETDB1 SETD1A PIK3CA MAP2K1
2 kinase activity GO:0016301 9.73 PIK3CA MAP2K1 EPHB2 CDKN2A CDK6 CCNE1
3 transcription regulatory region sequence-specific DNA binding GO:0000976 9.67 TP53 SP1 HNF4A GFI1
4 DNA binding GO:0003677 9.65 TP53 SP1 SETDB1 HNF4A HIRA GFI1
5 MDM2/MDM4 family protein binding GO:0097371 9.32 TP53 CDKN2A
6 chromatin binding GO:0003682 9.1 TP53 SETDB1 HNF4A CHAF1A ASF1A APTX

Sources for Prostate Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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