MCID: PRS004
MIFTS: 29

Prostate Squamous Cell Carcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Prostate Squamous Cell Carcinoma

MalaCards integrated aliases for Prostate Squamous Cell Carcinoma:

Name: Prostate Squamous Cell Carcinoma 12 15
Squamous Cell Carcinoma of Prostate 12 73
Squamous Cell Carcinoma of the Prostate 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10287
NCIt 50 C5536
SNOMED-CT 68 399590005
UMLS 73 C1302530

Summaries for Prostate Squamous Cell Carcinoma

MalaCards based summary : Prostate Squamous Cell Carcinoma, also known as squamous cell carcinoma of prostate, is related to rare adenocarcinoma of the breast and adult hepatocellular carcinoma. An important gene associated with Prostate Squamous Cell Carcinoma is TP53 (Tumor Protein P53), and among its related pathways/superpathways are Developmental Biology and Cytokine Signaling in Immune system. Affiliated tissues include prostate, and related phenotype is neoplasm.

Related Diseases for Prostate Squamous Cell Carcinoma

Diseases related to Prostate Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 186)
# Related Disease Score Top Affiliating Genes
1 rare adenocarcinoma of the breast 10.9 PIK3CA TP53
2 adult hepatocellular carcinoma 10.9 PIK3CA TP53
3 submandibular gland cancer 10.9 KLK3 TP53
4 atrophy of prostate 10.8 KLK3 TP53
5 prostate transitional cell carcinoma 10.8 KLK3 PIK3CA
6 ethmoid sinus cancer 10.8 HRAS PIK3CA
7 calcifying epithelial odontogenic tumor 10.8 KRT8 TP53
8 ethmoid sinus adenocarcinoma 10.8 HRAS PIK3CA
9 uterine body mixed cancer 10.8 PPP2R1A TP53
10 vulvar intraepithelial neoplasia 10.7 KRT5 TP53
11 anal squamous cell carcinoma 10.7 PIK3CA TP53
12 keratinizing squamous cell carcinoma 10.7 KRT5 TP53
13 sarcomatoid squamous cell skin carcinoma 10.7 KRT5 TP53
14 bartholin's duct cyst 10.7 SMUG1 TP53
15 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 10.7 PIK3CA PPP2R1A TP53
16 cellular ependymoma 10.7 SMUG1 TP53
17 mucoepidermoid esophageal carcinoma 10.6 CEACAM5 TP53
18 benign struma ovarii 10.6 HRAS SMUG1
19 intracranial chondrosarcoma 10.6 CEACAM5 TP53
20 sigmoid neoplasm 10.6 CEACAM5 HRAS
21 spitz nevus 10.6 HRAS LRRC56 TP53
22 prostatic cyst 10.6 KLK3 SMUG1
23 pilocytic astrocytoma 10.6 HRAS PIK3CA TP53
24 atypical follicular adenoma 10.6 CEACAM5 TP53
25 skin melanoma 10.5 HRAS PIK3CA TP53
26 prostate signet ring cell adenocarcinoma 10.5 CEACAM5 KLK3
27 female urethral cancer 10.5 CEACAM5 KLK3
28 breast squamous cell carcinoma 10.5 KRT5 PIK3CA TP53
29 secondary hypertrophic osteoarthropathy 10.5 HRAS SMUG1
30 prostate lymphoma 10.5 KLK3 SMUG1
31 scrotal carcinoma 10.5 SMUG1 TP53
32 female reproductive endometrioid cancer 10.5 KRT7 TP53
33 eccrine sweat gland neoplasm 10.5 KRT7 TP53
34 esophageal adenosquamous carcinoma 10.4 CEACAM5 KRT5
35 bladder carcinoma in situ 10.4 KRT7 TP53
36 mature teratoma 10.4 SMUG1 TP53
37 liver lymphoma 10.4 CEACAM5 SMUG1
38 splenic tuberculosis 10.4 CEACAM5 SMUG1
39 seminal vesicle adenocarcinoma 10.4 KLK3 KRT7
40 papillary serous adenocarcinoma 10.4 KRT7 TP53
41 proliferating trichilemmal cyst 10.3 KRT7 KRT8
42 breast disease 10.3 KLK3 KRT5 TP53
43 apocrine adenoma 10.3 CEACAM5 HRAS PIK3CA
44 endolymphatic sac tumor 10.3 KRT7 KRT8
45 spiradenoma 10.3 KRT7 TP53
46 aggressive digital papillary adenocarcinoma 10.3 CEACAM5 HRAS PIK3CA
47 ductal carcinoma in situ 10.3 KRT5 KRT8 TP53
48 intestinal benign neoplasm 10.3 CEACAM5 HRAS TP53
49 rete testis adenocarcinoma 10.3 CEACAM5 KLK3
50 inverted transitional papilloma 10.3 KRT5 KRT7

Graphical network of the top 20 diseases related to Prostate Squamous Cell Carcinoma:



Diseases related to Prostate Squamous Cell Carcinoma

Symptoms & Phenotypes for Prostate Squamous Cell Carcinoma

MGI Mouse Phenotypes related to Prostate Squamous Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.1 B2M HRAS PIK3CA PPP2R1A SMUG1 TP53

Drugs & Therapeutics for Prostate Squamous Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Prostate Squamous Cell Carcinoma

Genetic Tests for Prostate Squamous Cell Carcinoma

Anatomical Context for Prostate Squamous Cell Carcinoma

MalaCards organs/tissues related to Prostate Squamous Cell Carcinoma:

41
Prostate

Publications for Prostate Squamous Cell Carcinoma

Articles related to Prostate Squamous Cell Carcinoma:

# Title Authors Year
1
Primary squamous cell carcinoma of the prostate. ( 11020062 )
2000
2
Schistosomiasis, metaplasia and squamous cell carcinoma of the prostate: histogenesis of the squamous cancer cells determined by localization of specific markers. ( 2415839 )
1985

Variations for Prostate Squamous Cell Carcinoma

Expression for Prostate Squamous Cell Carcinoma

Search GEO for disease gene expression data for Prostate Squamous Cell Carcinoma.

Pathways for Prostate Squamous Cell Carcinoma

Pathways related to Prostate Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.23 HRAS KRT5 KRT7 KRT8 MED12 PIK3CA
2
Show member pathways
13.13 B2M HLA-A HRAS PIK3CA PPP2R1A TP53
3
Show member pathways
12.72 HLA-A HRAS PIK3CA PPP2R1A TP53
4
Show member pathways
12.33 HLA-A HRAS PIK3CA TP53
5
Show member pathways
12.17 HRAS PIK3CA PPP2R1A TP53
6 12.14 HLA-A HRAS PIK3CA TP53
7
Show member pathways
11.94 HRAS PIK3CA TP53
8 11.93 HLA-A HRAS PIK3CA TP53
9
Show member pathways
11.92 HRAS KLK3 PIK3CA
10
Show member pathways
11.83 HRAS PIK3CA TP53
11 11.77 HRAS PIK3CA TP53
12 11.76 HLA-A HRAS PIK3CA TP53
13
Show member pathways
11.73 KRT5 KRT7 KRT8
14 11.57 HRAS PIK3CA PPP2R1A TP53
15 11.4 HRAS PIK3CA TP53
16 11.36 HRAS PIK3CA TP53
17 11.33 HRAS PIK3CA PPP2R1A TP53
18 10.99 HRAS MED12 PIK3CA TP53
19 10.82 HRAS PIK3CA

GO Terms for Prostate Squamous Cell Carcinoma

Cellular components related to Prostate Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.76 B2M CEACAM5 HLA-A KLK3 KRT5 KRT7
2 keratin filament GO:0045095 9.13 KRT5 KRT7 KRT8
3 MHC class I protein complex GO:0042612 8.62 B2M HLA-A

Biological processes related to Prostate Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of anoikis GO:2000811 9.16 CEACAM5 PIK3CA
2 cornification GO:0070268 9.13 KRT5 KRT7 KRT8
3 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 8.62 B2M HLA-A

Sources for Prostate Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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