MCID: PRS009
MIFTS: 28

Prostate Stromal Sarcoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Prostate Stromal Sarcoma

MalaCards integrated aliases for Prostate Stromal Sarcoma:

Name: Prostate Stromal Sarcoma 12 15 70
Stromal Sarcoma of the Prostate 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7152
NCIt 50 C5524
UMLS 70 C1335521

Summaries for Prostate Stromal Sarcoma

Disease Ontology : 12 A stromal sarcoma and sarcoma of prostate and tumor of specialized prostatic stroma that is located in the prostate.

MalaCards based summary : Prostate Stromal Sarcoma, also known as stromal sarcoma of the prostate, is related to spindle cell sarcoma and prostate sarcoma. An important gene associated with Prostate Stromal Sarcoma is KLK3 (Kallikrein Related Peptidase 3), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Innate Lymphoid Cell Differentiation Pathways. Affiliated tissues include prostate, and related phenotypes are muscle and normal

Related Diseases for Prostate Stromal Sarcoma

Diseases related to Prostate Stromal Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 326)
# Related Disease Score Top Affiliating Genes
1 spindle cell sarcoma 30.2 MYOG KIT CD34
2 prostate sarcoma 30.0 PGR MYOG KLK3 CD34
3 gastrointestinal stromal tumor 29.5 SYP NCAM1 KIT CD34 ANO1
4 prostate leiomyoma 10.4 KLK3 CD34
5 breast leiomyoma 10.4 PGR CD34
6 glomangioma 10.4 SYP CD34
7 peritoneal benign neoplasm 10.4 PGR CD34
8 glomangiomyoma 10.4 SYP CD34
9 nodular prostate 10.4 SYP KLK3
10 pleomorphic lipoma 10.3 PGR CD34
11 glycogen-rich clear cell breast carcinoma 10.3 SYP PGR
12 subungual glomus tumor 10.3 SYP CD34
13 anal neuroendocrine tumor 10.3 SYP NCAM1
14 bladder lateral wall cancer 10.3 SYP KLK3
15 ovarian endometrioid stromal sarcoma 10.3 SYP PGR
16 scleredema adultorum 10.3 NCAM1 CD34
17 parasagittal meningioma 10.3 CD34 ANO1
18 esophageal neuroendocrine tumor 10.3 SYP NCAM1
19 pancreatic serous cystadenocarcinoma 10.3 SYP NCAM1
20 spinal cord sarcoma 10.3 KIT CD34
21 hypoganglionosis 10.3 SYP NCAM1
22 gallbladder small cell carcinoma 10.3 SYP NCAM1
23 ureter small cell carcinoma 10.3 SYP NCAM1
24 papillary thymic adenocarcinoma 10.3 SYP NCAM1
25 cerebellopontine angle primitive neuroectodermal tumor 10.3 SYP NCAM1
26 gallbladder leiomyoma 10.3 KIT CD34
27 prostatic hyperplasia, benign 10.3 PCA3 KLK3
28 urinary bladder small cell neuroendocrine carcinoma 10.3 SYP NCAM1
29 gastric small cell carcinoma 10.3 SYP NCAM1
30 transitional meningioma 10.3 PGR NCAM1
31 sensory organ benign neoplasm 10.3 SYP NCAM1
32 peritoneal serous adenocarcinoma 10.3 SYP PGR
33 laryngeal neuroendocrine tumor 10.3 SYP NCAM1
34 ovarian large-cell neuroendocrine carcinoma 10.3 SYP NCAM1
35 subependymoma 10.3 SYP NCAM1
36 angiomyoma 10.3 KIT CD34
37 central epithelioid sarcoma 10.3 SYP CD34
38 vulvar proximal-type epithelioid sarcoma 10.3 SYP CD34
39 gallbladder leiomyosarcoma 10.3 KIT CD34
40 pulmonary artery leiomyosarcoma 10.3 CD34 ANO1
41 benign fibrous mesothelioma 10.3 KIT CD34
42 chordoid glioma 10.3 SYP PGR
43 retroperitoneal hemangiopericytoma 10.3 KIT CD34
44 breast leiomyosarcoma 10.3 KIT CD34
45 ovary sarcoma 10.3 SYP PGR
46 liver fibroma 10.3 KIT CD34
47 biliary tract benign neoplasm 10.3 SYP NCAM1
48 pulmonary large cell neuroendocrine carcinoma 10.3 SYP NCAM1
49 adult cystic nephroma 10.3 PGR KIT
50 intrahepatic bile duct adenoma 10.3 NCAM1 KLK3

Graphical network of the top 20 diseases related to Prostate Stromal Sarcoma:



Diseases related to Prostate Stromal Sarcoma

Symptoms & Phenotypes for Prostate Stromal Sarcoma

MGI Mouse Phenotypes related to Prostate Stromal Sarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.56 ANO1 CSNK2A1 ESR1 KIT KLK3 MYOD1
2 normal MP:0002873 9.17 ESR1 KIT KLK3 MYOD1 MYOG PGR

Drugs & Therapeutics for Prostate Stromal Sarcoma

Search Clinical Trials , NIH Clinical Center for Prostate Stromal Sarcoma

Genetic Tests for Prostate Stromal Sarcoma

Anatomical Context for Prostate Stromal Sarcoma

The Foundational Model of Anatomy Ontology organs/tissues related to Prostate Stromal Sarcoma:

19
Prostate

MalaCards organs/tissues related to Prostate Stromal Sarcoma:

40
Prostate

Publications for Prostate Stromal Sarcoma

Articles related to Prostate Stromal Sarcoma:

(show all 12)
# Title Authors PMID Year
1
18F-FDG PET/CT Imaging of Prostate Stromal Tumor of Uncertain Malignant Potential. 61
33492862 2021
2
Clinical and Pathological Features of Prostatic Stromal Tumor of Uncertain Malignant Potential: A Retrospective Study of 23 Chinese Cases. 61
33221793 2021
3
A case of prostate stromal sarcoma involving the rectum. 61
32582434 2020
4
Stromal sarcoma of the prostate. 61
30797253 2019
5
Primary prostate sarcoma: how to manage following diagnosis at transurethral resection. 61
27147716 2016
6
Two different surgical approaches for prostatic stromal sarcoma: robot-assisted laparoscopic radical prostatectomy and open radical cysto-prostatectomy with ileal conduit. 61
25237465 2014
7
Common chromosomal aberrations detected by array comparative genomic hybridization in specialized stromal tumors of the prostate. 61
23765249 2013
8
Prostatic stromal tumor with fatal outcome in a young man: histopathological and immunohistochemical case presentation. 61
21234249 2010
9
Primary high grade sarcoma of the specialised prostatic stroma: a case report with clinico-pathological considerations. 61
19475893 2008
10
Synchronous prostate stromal sarcoma and gastrointestinal stromal tumor of rectum: case report and review of the literature. 61
16979698 2006
11
Prostatic stromal sarcoma in a young adult: a case report. 61
16214726 2005
12
Stromal sarcoma of the prostate. 61
10718190 2000

Variations for Prostate Stromal Sarcoma

Expression for Prostate Stromal Sarcoma

Search GEO for disease gene expression data for Prostate Stromal Sarcoma.

Pathways for Prostate Stromal Sarcoma

GO Terms for Prostate Stromal Sarcoma

Cellular components related to Prostate Stromal Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 SCARA5 NCAM1 KIT CD34

Biological processes related to Prostate Stromal Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid hormone mediated signaling pathway GO:0043401 9.48 PGR ESR1
2 positive regulation of myoblast differentiation GO:0045663 9.46 MYOG MYOD1
3 myoblast differentiation GO:0045445 9.43 MYOG MYOD1
4 myotube differentiation GO:0014902 9.4 MYOG MYOD1
5 positive regulation of phospholipase C activity GO:0010863 9.37 KIT ESR1
6 intracellular steroid hormone receptor signaling pathway GO:0030518 9.32 PGR ESR1
7 positive regulation of skeletal muscle fiber development GO:0048743 9.26 MYOG MYOD1
8 paracrine signaling GO:0038001 9.16 PGR CD34
9 muscle cell fate commitment GO:0042693 8.96 MYOG MYOD1
10 cellular response to estradiol stimulus GO:0071392 8.8 MYOG MYOD1 ESR1

Molecular functions related to Prostate Stromal Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid hormone receptor activity GO:0003707 8.62 PGR ESR1

Sources for Prostate Stromal Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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