MCID: PRS027
MIFTS: 28

Prostate Transitional Cell Carcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Prostate Transitional Cell Carcinoma

MalaCards integrated aliases for Prostate Transitional Cell Carcinoma:

Name: Prostate Transitional Cell Carcinoma 12 15
Transitional Cell Carcinoma of Prostate 12
Primary Prostate Urothelial Carcinoma 71

Classifications:



External Ids:

Disease Ontology 12 DOID:4011
UMLS 71 C1514430

Summaries for Prostate Transitional Cell Carcinoma

Disease Ontology : 12 A prostate carcinoma that derives from transitional epithelial cells.

MalaCards based summary : Prostate Transitional Cell Carcinoma, also known as transitional cell carcinoma of prostate, is related to transitional cell carcinoma and adrenomyeloneuropathy. An important gene associated with Prostate Transitional Cell Carcinoma is CLDN7 (Claudin 7), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and Cell junction organization. Affiliated tissues include prostate and lymph node, and related phenotypes are growth/size/body region and integument

Related Diseases for Prostate Transitional Cell Carcinoma

Diseases related to Prostate Transitional Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
# Related Disease Score Top Affiliating Genes
1 transitional cell carcinoma 10.5
2 adrenomyeloneuropathy 10.3 SLC25A17 AMACR
3 nephrogenic adenoma 10.3 KLK3 AMACR
4 lactase deficiency, congenital 10.3 CLDN7 CLDN3 CLDN1
5 urethra clear cell adenocarcinoma 10.3 KLK3 AMACR
6 urethra adenocarcinoma 10.3 KLK3 AMACR
7 wolffian duct adenoma 10.3 KLK3 AMACR
8 seminal vesicle adenocarcinoma 10.2 KLK3 AMACR
9 adenosquamous prostate carcinoma 10.2 KLK3 AMACR
10 urethra cancer 10.2 KLK3 AMACR
11 female urethral cancer 10.2 KLK3 AMACR
12 urethral diverticulum 10.2 KLK3 AMACR
13 glandular cystitis 10.2 KLK3 AMACR
14 refsum disease, classic 10.2 SLC25A17 AMACR ABCD3
15 in situ carcinoma 10.1
16 bladder adenocarcinoma 10.1 KLK3 AMACR
17 bladder cancer 10.1
18 prostate adenoid cystic carcinoma 10.0 KLK3 AR
19 prostate leiomyoma 10.0 KLK3 AR
20 prostate calculus 9.9 KLK3 AR
21 prostatic hypertrophy 9.9
22 urethritis 9.9
23 rare tumor 9.9
24 pancreatoblastoma 9.9 CLDN7 CLDN3
25 prostate cancer 9.9
26 bladder urothelial carcinoma 9.9
27 bladder lateral wall cancer 9.9 MAPK14 KLK3 AMACR
28 prostate neuroendocrine neoplasm 9.9 KLK3 AR
29 prostatic acinar adenocarcinoma 9.8 KLK3 AR AMACR
30 eccrine papillary adenocarcinoma 9.7 KRT5 KLK3
31 papillary adenoma 9.7 KRT5 AMACR
32 prostatic hyperplasia, benign 9.7 KLK3 AR
33 epididymis adenocarcinoma 9.7 KRT5 KLK3
34 epididymis cancer 9.7 KRT5 KLK3
35 male urethral cancer 9.7 KRT5 KLK3 AMACR
36 nephrogenic adenoma of the urethra 9.7 KRT5 KLK3 AMACR
37 urethral benign neoplasm 9.7 KRT5 KLK3 AMACR
38 vulvar apocrine adenocarcinoma 9.6 KRT5 AR
39 apocrine adenocarcinoma 9.6 KRT5 AR
40 apocrine sweat gland neoplasm 9.5 KRT5 AR
41 ductal carcinoma in situ 9.4 KRT5 CLDN7 AR
42 paget disease, extramammary 9.3 KRT5 AR
43 suppression of tumorigenicity 12 9.2 KRT5 KLK3 AR AMACR

Graphical network of the top 20 diseases related to Prostate Transitional Cell Carcinoma:



Diseases related to Prostate Transitional Cell Carcinoma

Symptoms & Phenotypes for Prostate Transitional Cell Carcinoma

MGI Mouse Phenotypes related to Prostate Transitional Cell Carcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.9 ABCD3 AMACR AMFR AR CLDN1 CLDN7
2 integument MP:0010771 9.56 ABCC3 AR CLDN1 CLDN7 KRT5 MAPK14
3 liver/biliary system MP:0005370 9.17 ABCC3 ABCD3 AMACR AMFR AR MAPK14

Drugs & Therapeutics for Prostate Transitional Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Prostate Transitional Cell Carcinoma

Genetic Tests for Prostate Transitional Cell Carcinoma

Anatomical Context for Prostate Transitional Cell Carcinoma

MalaCards organs/tissues related to Prostate Transitional Cell Carcinoma:

40
Prostate, Lymph Node

Publications for Prostate Transitional Cell Carcinoma

Articles related to Prostate Transitional Cell Carcinoma:

(show all 17)
# Title Authors PMID Year
1
Claudin-1, -3, -4 and -7 gene expression analyses in canine prostate carcinoma and mammary tissue derived cell lines. 61
26774145 2016
2
Diagnostic dilemma in histopathology report following robot assisted laparoscopic prostatectomy: tumour 'hide and seek'. 61
24061454 2013
3
[Pure primary prostate transitional cell carcinoma. A review of our series]. 61
15264680 2004
4
Morphological features correlation with serum tumour markers in prostatic carcinoma. 61
12971871 2003
5
Case report--Cutaneous metastasis from a primary transitional cell carcinoma of prostate. 61
12230282 2001
6
[Primary transitional cell carcinoma of prostate: a case report]. 61
10965459 2000
7
[Primary transitional carcinoma of the prostatic ductus]. 61
10965577 2000
8
Does prostate transitional cell carcinoma preclude orthotopic bladder reconstruction after radical cystoprostatectomy for bladder cancer? 61
9366327 1997
9
Is stage pT4a (D1) reliable in assessing transitional cell carcinoma involvement of the prostate in patients with a concurrent bladder cancer? A necessary distinction for contiguous or noncontiguous involvement. 61
7490845 1996
10
The application of laparoscopy to retroperitoneal surgery in urology. 61
8239734 1993
11
Transitional cell carcinoma of the prostate in patients undergoing radical cystoprostatectomy. 61
1729557 1992
12
Primary transitional cell carcinoma of prostate: case with lymph node metastasis eradicated by neoadjuvant methotrexate, vinblastine, doxorubicin, and cisplatin (M-VAC) therapy. 61
2368239 1990
13
[Usefulness of transurethral resection in cancer of the prostate]. 61
2639620 1989
14
Primary transitional cell carcinoma of prostate. 61
6506393 1984
15
Transitional cell carcinoma of prostate. 61
1129899 1975
16
Transitional-cell carcinoma of prostate. An enigma. 61
4769516 1973
17
Primary transitional cell carcinoma of prostate gland: possible pathogenesis and relationship to reserve cell hyperplasia of prostatic periurethral ducts. 61
4179564 1969

Variations for Prostate Transitional Cell Carcinoma

Expression for Prostate Transitional Cell Carcinoma

Search GEO for disease gene expression data for Prostate Transitional Cell Carcinoma.

Pathways for Prostate Transitional Cell Carcinoma

Pathways related to Prostate Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.74 SOS1 MAPK14 CLDN7 CLDN3 CLDN1
2
Show member pathways
12.45 MAPK14 CLDN7 CLDN3 CLDN1
3
Show member pathways
12.32 MAPK14 CLDN7 CLDN3 CLDN1
4
Show member pathways
12.18 SOS1 CLDN7 CLDN3 CLDN1
5 11.86 CLDN7 CLDN3 CLDN1
6 11.74 MAPK14 CLDN7 CLDN3 CLDN1
7 11.67 KLK3 CLDN3 CLDN1
8 11.53 SOS1 MAPK14 AR
9 11.35 SLC25A17 AMACR ABCD3
10
Show member pathways
11.08 CLDN7 CLDN3 CLDN1 ABCC3
11 10.86 SOS1 MAPK14
12 10.84 MAPK14 ABCC3
13 10.83 MAPK14 KLK3 AR

GO Terms for Prostate Transitional Cell Carcinoma

Cellular components related to Prostate Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peroxisome GO:0005777 9.5 SLC25A17 AMACR ABCD3
2 bicellular tight junction GO:0005923 9.43 CLDN7 CLDN3 CLDN1
3 apicolateral plasma membrane GO:0016327 9.37 CLDN7 CLDN3
4 tight junction GO:0070160 9.16 CLDN3 CLDN1
5 lateral plasma membrane GO:0016328 9.13 CLDN7 CLDN3 CLDN1
6 protein-containing complex GO:0032991 9.1 MTA2 KLK3 CLDN3 CLDN1 AR AMFR

Biological processes related to Prostate Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to ethanol GO:0045471 9.58 CLDN7 CLDN3 CLDN1
2 positive regulation of wound healing GO:0090303 9.46 CLDN3 CLDN1
3 epithelial cell morphogenesis GO:0003382 9.43 CLDN3 AR
4 bicellular tight junction assembly GO:0070830 9.43 CLDN7 CLDN3 CLDN1
5 regulation of systemic arterial blood pressure GO:0003073 9.37 KLK3 AR
6 positive regulation of metallopeptidase activity GO:1905050 9.32 MAPK14 CLDN3
7 positive regulation of bicellular tight junction assembly GO:1903348 9.16 CLDN3 CLDN1
8 cell junction maintenance GO:0034331 8.96 CLDN3 CLDN1
9 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules GO:0016338 8.8 CLDN7 CLDN3 CLDN1

Molecular functions related to Prostate Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 8.92 CRYBB2 CLDN7 CLDN3 CLDN1

Sources for Prostate Transitional Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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