Prostate Transitional Cell Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Prostate Transitional Cell Carcinoma

MalaCards integrated aliases for Prostate Transitional Cell Carcinoma:

Name: Prostate Transitional Cell Carcinoma ¹² ¹⁵

Transitional Cell Carcinoma of Prostate ¹²

Primary Prostate Urothelial Carcinoma ⁷⁴

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:4011

UMLS ⁷⁴ C1514430

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Summaries for Prostate Transitional Cell Carcinoma

Disease Ontology : ¹² A prostate carcinoma that derives from transitional epithelial cells.

MalaCards based summary : Prostate Transitional Cell Carcinoma, also known as transitional cell carcinoma of prostate, is related to transitional cell carcinoma and adult hepatocellular carcinoma. An important gene associated with Prostate Transitional Cell Carcinoma is PIK3CA (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha), and among its related pathways/superpathways are Integrin Pathway and Sertoli-Sertoli Cell Junction Dynamics. Related phenotype is Increased cell death HMECs cells.

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Related Diseases for Prostate Transitional Cell Carcinoma

Diseases related to Prostate Transitional Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 22)

#	Related Disease	Score	Top Affiliating Genes
1	transitional cell carcinoma	10.3
2	adult hepatocellular carcinoma	10.1	CTNNB1 PIK3CA
3	hemimegalencephaly	10.1	CTNNB1 PIK3CA
4	epstein-barr virus-associated gastric carcinoma	10.1	CTNNB1 PIK3CA
5	uterine anomalies	10.1	CTNNB1 PIK3CA
6	carcinosarcoma	10.1	CTNNB1 PIK3CA
7	respiratory system cancer	10.1	CTNNB1 PIK3CA
8	prostate adenoid cystic carcinoma	10.0	KLK3 PIK3CA
9	uterine carcinosarcoma	10.0	CTNNB1 PIK3CA
10	intestinal disease	10.0	CTNNB1 PIK3CA
11	urinary tract obstruction	10.0	KLK3 PIK3CA
12	cystitis cystica	10.0	CTNNB1 KLK3
13	gastrointestinal system cancer	10.0	CTNNB1 PIK3CA
14	male reproductive organ cancer	9.9	CTNNB1 KLK3
15	bladder cancer	9.9
16	reproductive system disease	9.9	CTNNB1 KLK3
17	suppression of tumorigenicity 12	9.8	CTNNB1 KLK3 PIK3CA
18	adrenocortical carcinoma, hereditary	9.8	CTNNB1 PIK3CA
19	bladder urothelial carcinoma	9.8	CTNNB1 KLK3 PIK3CA
20	adamantinoma of long bones	9.8	CTNNB1 KLK3 PIK3CA
21	endometrial cancer	9.6	CLDN3 CTNNB1 PIK3CA
22	gastric adenocarcinoma	9.4	CLDN3 CLDN7 CTNNB1 PIK3CA

Graphical network of the top 20 diseases related to Prostate Transitional Cell Carcinoma:

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Symptoms & Phenotypes for Prostate Transitional Cell Carcinoma

GenomeRNAi Phenotypes related to Prostate Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

²⁷

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased cell death HMECs cells	GR00103-A-0	8.92	CLDN1 CTNNB1 KLK3 PIK3CA

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Drugs & Therapeutics for Prostate Transitional Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Prostate Transitional Cell Carcinoma

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Genetic Tests for Prostate Transitional Cell Carcinoma

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Anatomical Context for Prostate Transitional Cell Carcinoma

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Publications for Prostate Transitional Cell Carcinoma

Articles related to Prostate Transitional Cell Carcinoma:

#	Title	Authors	Year
1	Does prostate transitional cell carcinoma preclude orthotopic bladder reconstruction after radical cystoprostatectomy for bladder cancer? ( 9366327 )	Iselin CE...Paulson DF	1997

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Genes for Prostate Transitional Cell Carcinoma

Genes related to Prostate Transitional Cell Carcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	17.98	GeneCards inferred via : Variants (show sections)
2	CTNNB1	Catenin Beta 1	Protein Coding	17.64	GeneCards inferred via : Variants (show sections)
3	CLDN1	Claudin 1	Protein Coding	15.96	DISEASES inferred ¹⁵
4	KLK3	Kallikrein Related Peptidase 3	Protein Coding	13.73	DISEASES inferred ¹⁵
5	CLDN7	Claudin 7	Protein Coding	5.89	DISEASES inferred ¹⁵
6	CLDN3	Claudin 3	Protein Coding	5.68	DISEASES inferred ¹⁵

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Variations for Prostate Transitional Cell Carcinoma

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Expression for Prostate Transitional Cell Carcinoma

Search GEO for disease gene expression data for Prostate Transitional Cell Carcinoma.

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Pathways for Prostate Transitional Cell Carcinoma

Pathways related to Prostate Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 22)

#	Super pathways	Score	Top Affiliating Genes
1	Integrin Pathway ⁶⁵ Show member pathways FAK1 Signaling ⁶⁵ GnRH Signaling ⁶⁵ Inhibition of Angiogenesis by TSP1 ⁶⁵ Transendothelial Migration of Leukocytes ⁶⁵ UPA-UPAR Pathway ⁶⁵	12.97	CLDN1 CLDN3 CLDN7 CTNNB1 PIK3CA
2	Sertoli-Sertoli Cell Junction Dynamics ⁶⁵ Show member pathways Epithelial Tight Junctions ⁶⁵ Germ Cell-Sertoli Cell Junction Dynamics ⁶⁵	12.58	CLDN1 CLDN3 CLDN7 CTNNB1
3	Endometrial cancer ³⁸ Show member pathways Acute myeloid leukemia ³⁸ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁷ Chronic myeloid leukemia ³⁸ Colorectal cancer ³⁸ Pancreatic cancer ³⁸ Prostate cancer ³⁸ Signal transduction PTEN pathway ²³ Thyroid cancer ³⁸	12.52	CTNNB1 KLK3 PIK3CA
4	Pathways in cancer ³⁸	12.48	CTNNB1 KLK3 PIK3CA
5	Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases ²³ Show member pathways Cell adhesion Integrin-mediated cell adhesion and migration ²³ Cell adhesion Tight junctions ²³ Cytoskeleton remodeling Integrin outside-in signaling ²³ Development MAG-dependent inhibition of neurite outgrowth ²³	12.26	CLDN1 CLDN3 CLDN7 CTNNB1
6	Cell junction organization ⁶⁷ Show member pathways Adherens junctions interactions ⁶⁷ Cell-Cell communication ⁶⁷ Cell-cell junction organization ⁶⁷ Cell-extracellular matrix interactions ⁶⁷ DSCAM interactions ⁶⁷ Localization of the PINCH-ILK-PARVIN complex to focal adhesions ⁶⁷ Nectin/Necl trans heterodimerization ⁶⁷ Regulation of cytoskeletal remodeling and cell spreading by IPP complex components ⁶⁷ Signal regulatory protein (SIRP) family interactions ⁶⁷ Tight junction interactions ⁶⁷ Type I hemidesmosome assembly ⁶⁷	11.97	CLDN1 CLDN3 CLDN7 CTNNB1 PIK3CA
7	Tight junction ³⁸	11.92	CLDN1 CLDN3 CLDN7
8	Transcription Androgen Receptor nuclear signaling ²³ Show member pathways Translation Non-genomic (rapid) action of Androgen Receptor ²³	11.82	CTNNB1 KLK3 PIK3CA
9	G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins ²³ Show member pathways G-protein signaling G-Protein alpha-12 signaling pathway ²³	11.82	CLDN1 CLDN3 CLDN7 CTNNB1 PIK3CA
10	Cell adhesion molecules (CAMs) ³⁸	11.8	CLDN1 CLDN3 CLDN7
11	DNA Damage Response (only ATM dependent) ¹	11.67	CTNNB1 PIK3CA
12	Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways ⁶⁶ Show member pathways Blood-Brain Barrier and Immune Cell Transmigration: CCL2/MCP-1 Signaling Pathways ⁶⁶ Blood-Brain Barrier and Immune Cell Transmigration: ICAM-1/CD54 Signaling Pathways ⁶⁶ Blood-Brain Barrier and Immune Cell Transmigration: VEGF Signaling Pathways ⁶⁶ Leukocyte transendothelial migration ³⁸	11.6	CLDN1 CLDN3 CLDN7 CTNNB1 PIK3CA
13	Signaling events mediated by VEGFR1 and VEGFR2 ¹ Show member pathways VEGFR1 specific signals ¹	11.56	CTNNB1 PIK3CA
14	Adhesion ⁴	11.55	CLDN1 CLDN3 CTNNB1 KLK3
15	Androgen receptor signaling pathway ¹	11.54	CTNNB1 KLK3
16	Bacterial invasion of epithelial cells ³⁸	11.44	CTNNB1 PIK3CA
17	Primary Focal Segmental Glomerulosclerosis FSGS ¹	11.43	CLDN1 CTNNB1
18	Coregulation of Androgen receptor activity ¹	11.3	CTNNB1 KLK3
19	E-cadherin signaling in the nascent adherens junction ¹	11.05	CTNNB1 PIK3CA
20	Cell adhesion_Endothelial cell contacts by junctional mechanisms ²³	11.05	CLDN1 CLDN3 CTNNB1
21	N-cadherin signaling events ¹	11.04	CTNNB1 PIK3CA
22	Nectin adhesion pathway ¹	10.83	CLDN1 CTNNB1 PIK3CA

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GO Terms for Prostate Transitional Cell Carcinoma

Cellular components related to Prostate Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell junction	GO:0030054	9.56	CLDN1 CLDN3 CLDN7 CTNNB1
2	basolateral plasma membrane	GO:0016323	9.33	CLDN1 CLDN7 CTNNB1
3	lateral plasma membrane	GO:0016328	9.13	CLDN1 CLDN3 CTNNB1
4	bicellular tight junction	GO:0005923	8.92	CLDN1 CLDN3 CLDN7 CTNNB1

Biological processes related to Prostate Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein heterooligomerization	GO:0051291	9.26	CLDN1 CLDN3
2	bicellular tight junction assembly	GO:0070830	9.16	CLDN1 CLDN3
3	vasculature development	GO:0001944	8.96	CTNNB1 PIK3CA
4	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules	GO:0016338	8.8	CLDN1 CLDN3 CLDN7

Molecular functions related to Prostate Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	structural molecule activity	GO:0005198	8.8	CLDN1 CLDN3 CLDN7

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