Prostate Transitional Cell Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Prostate Transitional Cell Carcinoma

MalaCards integrated aliases for Prostate Transitional Cell Carcinoma:

Name: Prostate Transitional Cell Carcinoma ¹² ¹⁵

Transitional Cell Carcinoma of Prostate ¹²

Primary Prostate Urothelial Carcinoma ⁷¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:4011

UMLS ⁷¹ C1514430

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Summaries for Prostate Transitional Cell Carcinoma

Disease Ontology : ¹² A prostate carcinoma that derives from transitional epithelial cells.

MalaCards based summary : Prostate Transitional Cell Carcinoma, also known as transitional cell carcinoma of prostate, is related to transitional cell carcinoma and adrenomyeloneuropathy. An important gene associated with Prostate Transitional Cell Carcinoma is CLDN7 (Claudin 7), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and Cell junction organization. Affiliated tissues include prostate and lymph node, and related phenotypes are growth/size/body region and integument

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Related Diseases for Prostate Transitional Cell Carcinoma

Diseases related to Prostate Transitional Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)

#	Related Disease	Score	Top Affiliating Genes
1	transitional cell carcinoma	10.5
2	adrenomyeloneuropathy	10.3	SLC25A17 AMACR
3	nephrogenic adenoma	10.3	KLK3 AMACR
4	lactase deficiency, congenital	10.3	CLDN7 CLDN3 CLDN1
5	urethra clear cell adenocarcinoma	10.3	KLK3 AMACR
6	urethra adenocarcinoma	10.3	KLK3 AMACR
7	wolffian duct adenoma	10.3	KLK3 AMACR
8	seminal vesicle adenocarcinoma	10.2	KLK3 AMACR
9	adenosquamous prostate carcinoma	10.2	KLK3 AMACR
10	urethra cancer	10.2	KLK3 AMACR
11	female urethral cancer	10.2	KLK3 AMACR
12	urethral diverticulum	10.2	KLK3 AMACR
13	glandular cystitis	10.2	KLK3 AMACR
14	refsum disease, classic	10.2	SLC25A17 AMACR ABCD3
15	in situ carcinoma	10.1
16	bladder adenocarcinoma	10.1	KLK3 AMACR
17	bladder cancer	10.1
18	prostate adenoid cystic carcinoma	10.0	KLK3 AR
19	prostate leiomyoma	10.0	KLK3 AR
20	prostate calculus	9.9	KLK3 AR
21	prostatic hypertrophy	9.9
22	urethritis	9.9
23	rare tumor	9.9
24	pancreatoblastoma	9.9	CLDN7 CLDN3
25	prostate cancer	9.9
26	bladder urothelial carcinoma	9.9
27	bladder lateral wall cancer	9.9	MAPK14 KLK3 AMACR
28	prostate neuroendocrine neoplasm	9.9	KLK3 AR
29	prostatic acinar adenocarcinoma	9.8	KLK3 AR AMACR
30	eccrine papillary adenocarcinoma	9.7	KRT5 KLK3
31	papillary adenoma	9.7	KRT5 AMACR
32	prostatic hyperplasia, benign	9.7	KLK3 AR
33	epididymis adenocarcinoma	9.7	KRT5 KLK3
34	epididymis cancer	9.7	KRT5 KLK3
35	male urethral cancer	9.7	KRT5 KLK3 AMACR
36	nephrogenic adenoma of the urethra	9.7	KRT5 KLK3 AMACR
37	urethral benign neoplasm	9.7	KRT5 KLK3 AMACR
38	vulvar apocrine adenocarcinoma	9.6	KRT5 AR
39	apocrine adenocarcinoma	9.6	KRT5 AR
40	apocrine sweat gland neoplasm	9.5	KRT5 AR
41	ductal carcinoma in situ	9.4	KRT5 CLDN7 AR
42	paget disease, extramammary	9.3	KRT5 AR
43	suppression of tumorigenicity 12	9.2	KRT5 KLK3 AR AMACR

Graphical network of the top 20 diseases related to Prostate Transitional Cell Carcinoma:

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Symptoms & Phenotypes for Prostate Transitional Cell Carcinoma

MGI Mouse Phenotypes related to Prostate Transitional Cell Carcinoma:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size/body region	MP:0005378	9.9	ABCD3 AMACR AMFR AR CLDN1 CLDN7
2	integument	MP:0010771	9.56	ABCC3 AR CLDN1 CLDN7 KRT5 MAPK14
3	liver/biliary system	MP:0005370	9.17	ABCC3 ABCD3 AMACR AMFR AR MAPK14

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Drugs & Therapeutics for Prostate Transitional Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Prostate Transitional Cell Carcinoma

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Genetic Tests for Prostate Transitional Cell Carcinoma

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Anatomical Context for Prostate Transitional Cell Carcinoma

MalaCards organs/tissues related to Prostate Transitional Cell Carcinoma:

⁴⁰

Prostate, Lymph Node

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Publications for Prostate Transitional Cell Carcinoma

Articles related to Prostate Transitional Cell Carcinoma:

(show all 17)

#	Title	Authors	PMID	Year
1	Claudin-1, -3, -4 and -7 gene expression analyses in canine prostate carcinoma and mammary tissue derived cell lines. ⁶¹	Hammer SC...Murua Escobar H	26774145	2016
2	Diagnostic dilemma in histopathology report following robot assisted laparoscopic prostatectomy: tumour 'hide and seek'. ⁶¹	Javali TD...Dinda AK	24061454	2013
3	[Pure primary prostate transitional cell carcinoma. A review of our series]. ⁶¹	Mallen Mateo E...Rioja Sanz LA	15264680	2004
4	Morphological features correlation with serum tumour markers in prostatic carcinoma. ⁶¹	Afzal S...Khan SA	12971871	2003
5	Case report--Cutaneous metastasis from a primary transitional cell carcinoma of prostate. ⁶¹	Mishra VC...Tindall SF	12230282	2001
6	[Primary transitional cell carcinoma of prostate: a case report]. ⁶¹	Uemura M...Mise T	10965459	2000
7	[Primary transitional carcinoma of the prostatic ductus]. ⁶¹	Queipo Zaragoza JA...Jimenez Cruz JF	10965577	2000
8	Does prostate transitional cell carcinoma preclude orthotopic bladder reconstruction after radical cystoprostatectomy for bladder cancer? ⁶¹	Iselin CE...Paulson DF	9366327	1997
9	Is stage pT4a (D1) reliable in assessing transitional cell carcinoma involvement of the prostate in patients with a concurrent bladder cancer? A necessary distinction for contiguous or noncontiguous involvement. ⁶¹	Pagano F...Garbeglio A	7490845	1996
10	The application of laparoscopy to retroperitoneal surgery in urology. ⁶¹	Rukstalis DB...Chodak GW	8239734	1993
11	Transitional cell carcinoma of the prostate in patients undergoing radical cystoprostatectomy. ⁶¹	Reese JH...Torti FM	1729557	1992
12	Primary transitional cell carcinoma of prostate: case with lymph node metastasis eradicated by neoadjuvant methotrexate, vinblastine, doxorubicin, and cisplatin (M-VAC) therapy. ⁶¹	Takashi M...Miyake K	2368239	1990
13	[Usefulness of transurethral resection in cancer of the prostate]. ⁶¹	Rodriguez JV...Chechile G	2639620	1989
14	Primary transitional cell carcinoma of prostate. ⁶¹	Nicolaisen GS...Williams RD	6506393	1984
15	Transitional cell carcinoma of prostate. ⁶¹	Tannenbaum M	1129899	1975
16	Transitional-cell carcinoma of prostate. An enigma. ⁶¹	Albert PS...Nagamatsu GR	4769516	1973
17	Primary transitional cell carcinoma of prostate gland: possible pathogenesis and relationship to reserve cell hyperplasia of prostatic periurethral ducts. ⁶¹	Karpas CM...Moumgis B	4179564	1969

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Genes for Prostate Transitional Cell Carcinoma

Genes related to Prostate Transitional Cell Carcinoma (0 elite genes):

(show all 17)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CLDN7	Claudin 7	Protein Coding	5.94	DISEASES inferred ¹⁵
2	CLDN1	Claudin 1	Protein Coding	5.85	DISEASES inferred ¹⁵
3	CLDN3	Claudin 3	Protein Coding	5.71	DISEASES inferred ¹⁵
4	AMACR	Alpha-Methylacyl-CoA Racemase	Protein Coding	5.67	DISEASES inferred ¹⁵
5	CRYBB2	Crystallin Beta B2	Protein Coding	5.29	DISEASES inferred ¹⁵
6	ABCD3	ATP Binding Cassette Subfamily D Member 3	Protein Coding	5.25	DISEASES inferred ¹⁵
7	SLC25A17	Solute Carrier Family 25 Member 17	Protein Coding	5.18	DISEASES inferred ¹⁵
8	RANGAP1	Ran GTPase Activating Protein 1	Protein Coding	5.1	DISEASES inferred ¹⁵
9	MTA2	Metastasis Associated 1 Family Member 2	Protein Coding	5.09	DISEASES inferred ¹⁵
10	ZBTB33	Zinc Finger And BTB Domain Containing 33	Protein Coding	4.99	DISEASES inferred ¹⁵
11	AMFR	Autocrine Motility Factor Receptor	Protein Coding	4.78	DISEASES inferred ¹⁵
12	KLK3	Kallikrein Related Peptidase 3	Protein Coding	4.73	DISEASES inferred ¹⁵
13	ABCC3	ATP Binding Cassette Subfamily C Member 3	Protein Coding	4.44	DISEASES inferred ¹⁵
14	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	4.36	DISEASES inferred ¹⁵
15	AR	Androgen Receptor	Protein Coding	4.33	DISEASES inferred ¹⁵
16	KRT5	Keratin 5	Protein Coding	3.64	DISEASES inferred ¹⁵
17	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	3.45	DISEASES inferred ¹⁵

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Variations for Prostate Transitional Cell Carcinoma

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Expression for Prostate Transitional Cell Carcinoma

Search GEO for disease gene expression data for Prostate Transitional Cell Carcinoma.

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Pathways for Prostate Transitional Cell Carcinoma

Pathways related to Prostate Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 13)

#	Super pathways	Score	Top Affiliating Genes
1	Toll-like Receptor Signaling Pathway ³⁶ ¹ Show member pathways Chagas disease (American trypanosomiasis) ³⁶ Hepatitis B ³⁶ Hepatitis C ³⁶ Regulation of toll-like receptor signaling pathway ¹	12.74	SOS1 MAPK14 CLDN7 CLDN3 CLDN1
2	Cell junction organization ⁶⁵ Show member pathways Adherens junctions interactions ⁶⁵ Cell-Cell communication ⁶⁵ Cell-cell junction organization ⁶⁵ Cell-extracellular matrix interactions ⁶⁵ DSCAM interactions ⁶⁵ Localization of the PINCH-ILK-PARVIN complex to focal adhesions ⁶⁵ Nectin/Necl trans heterodimerization ⁶⁵ Regulation of cytoskeletal remodeling and cell spreading by IPP complex components ⁶⁵ Signal regulatory protein (SIRP) family interactions ⁶⁵ Tight junction interactions ⁶⁵ Type I hemidesmosome assembly ⁶⁵	12.45	MAPK14 CLDN7 CLDN3 CLDN1
3	Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling ⁶⁴ Show member pathways Blood-Brain Barrier and Immune Cell Transmigration: CCL2/MCP-1 Signaling ⁶⁴ Blood-Brain Barrier and Immune Cell Transmigration: ICAM-1/CD54 Signaling ⁶⁴ Blood-Brain Barrier and Immune Cell Transmigration: VEGF Signaling ⁶⁴ Leukocyte transendothelial migration ³⁶	12.32	MAPK14 CLDN7 CLDN3 CLDN1
4	Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases ²² Show member pathways Cell adhesion Integrin-mediated cell adhesion and migration ²² Cell adhesion Tight junctions ²² Cytoskeleton remodeling Integrin outside-in signaling ²² Development MAG-dependent inhibition of neurite outgrowth ²²	12.18	SOS1 CLDN7 CLDN3 CLDN1
5	Cell adhesion molecules (CAMs) ³⁶	11.86	CLDN7 CLDN3 CLDN1
6	Pathogenic Escherichia coli infection ³⁶	11.74	MAPK14 CLDN7 CLDN3 CLDN1
7	Adhesion ⁴	11.67	KLK3 CLDN3 CLDN1
8	TGF-beta Signaling Pathways ⁶⁴	11.53	SOS1 MAPK14 AR
9	Peroxisome ³⁶	11.35	SLC25A17 AMACR ABCD3
10	Blood-Brain Barrier: Anatomy ⁶⁴ Show member pathways Blood-Brain Barrier and Immune Cell Transmigration: Overview ⁶⁴	11.08	CLDN7 CLDN3 CLDN1 ABCC3
11	VEGFR3 signaling in lymphatic endothelium ¹	10.86	SOS1 MAPK14
12	Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling ¹	10.84	MAPK14 ABCC3
13	Regulation of Androgen receptor activity ¹	10.83	MAPK14 KLK3 AR

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GO Terms for Prostate Transitional Cell Carcinoma

Cellular components related to Prostate Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	peroxisome	GO:0005777	9.5	SLC25A17 AMACR ABCD3
2	bicellular tight junction	GO:0005923	9.43	CLDN7 CLDN3 CLDN1
3	apicolateral plasma membrane	GO:0016327	9.37	CLDN7 CLDN3
4	tight junction	GO:0070160	9.16	CLDN3 CLDN1
5	lateral plasma membrane	GO:0016328	9.13	CLDN7 CLDN3 CLDN1
6	protein-containing complex	GO:0032991	9.1	MTA2 KLK3 CLDN3 CLDN1 AR AMFR

Biological processes related to Prostate Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	response to ethanol	GO:0045471	9.58	CLDN7 CLDN3 CLDN1
2	positive regulation of wound healing	GO:0090303	9.46	CLDN3 CLDN1
3	epithelial cell morphogenesis	GO:0003382	9.43	CLDN3 AR
4	bicellular tight junction assembly	GO:0070830	9.43	CLDN7 CLDN3 CLDN1
5	regulation of systemic arterial blood pressure	GO:0003073	9.37	KLK3 AR
6	positive regulation of metallopeptidase activity	GO:1905050	9.32	MAPK14 CLDN3
7	positive regulation of bicellular tight junction assembly	GO:1903348	9.16	CLDN3 CLDN1
8	cell junction maintenance	GO:0034331	8.96	CLDN3 CLDN1
9	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules	GO:0016338	8.8	CLDN7 CLDN3 CLDN1

Molecular functions related to Prostate Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	structural molecule activity	GO:0005198	8.92	CRYBB2 CLDN7 CLDN3 CLDN1

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