MCID: PRS027
MIFTS: 26

Prostate Transitional Cell Carcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Prostate Transitional Cell Carcinoma

MalaCards integrated aliases for Prostate Transitional Cell Carcinoma:

Name: Prostate Transitional Cell Carcinoma 12 15
Transitional Cell Carcinoma of Prostate 12
Primary Prostate Urothelial Carcinoma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4011
UMLS 73 C1514430

Summaries for Prostate Transitional Cell Carcinoma

MalaCards based summary : Prostate Transitional Cell Carcinoma, also known as transitional cell carcinoma of prostate, is related to adult hepatocellular carcinoma and hemimegalencephaly. An important gene associated with Prostate Transitional Cell Carcinoma is PIK3CA (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha), and among its related pathways/superpathways are Integrin Pathway and Sertoli-Sertoli Cell Junction Dynamics. Affiliated tissues include prostate, and related phenotype is Increased cell death HMECs cells.

Related Diseases for Prostate Transitional Cell Carcinoma

Graphical network of the top 20 diseases related to Prostate Transitional Cell Carcinoma:



Diseases related to Prostate Transitional Cell Carcinoma

Symptoms & Phenotypes for Prostate Transitional Cell Carcinoma

GenomeRNAi Phenotypes related to Prostate Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death HMECs cells GR00103-A-0 8.92 CLDN1 CTNNB1 KLK3 PIK3CA

Drugs & Therapeutics for Prostate Transitional Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Prostate Transitional Cell Carcinoma

Genetic Tests for Prostate Transitional Cell Carcinoma

Anatomical Context for Prostate Transitional Cell Carcinoma

MalaCards organs/tissues related to Prostate Transitional Cell Carcinoma:

41
Prostate

Publications for Prostate Transitional Cell Carcinoma

Articles related to Prostate Transitional Cell Carcinoma:

# Title Authors Year
1
Prostatic transitional cell carcinoma: pathologic features and clinical management. ( 18028024 )
2007
2
Changes of phenotypic expression of prostatic antigen in secondary transitional cell carcinoma of the prostate: evidence for induction phenomenon as a mechanism for acquisition of prostatic antigens in prostatic transitional cell carcinoma. ( 11351346 )
2001
3
Does prostate transitional cell carcinoma preclude orthotopic bladder reconstruction after radical cystoprostatectomy for bladder cancer? ( 9366327 )
1997

Variations for Prostate Transitional Cell Carcinoma

Expression for Prostate Transitional Cell Carcinoma

Search GEO for disease gene expression data for Prostate Transitional Cell Carcinoma.

Pathways for Prostate Transitional Cell Carcinoma

Pathways related to Prostate Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.99 CLDN1 CLDN3 CLDN7 CTNNB1 PIK3CA
2
Show member pathways
12.6 CLDN1 CLDN3 CLDN7 CTNNB1
3
Show member pathways
12.53 CTNNB1 KLK3 PIK3CA
4 12.48 CTNNB1 KLK3 PIK3CA
5
Show member pathways
12.29 CLDN1 CLDN3 CLDN7 CTNNB1
6
Show member pathways
11.97 CLDN1 CLDN3 CLDN7 CTNNB1 PIK3CA
7 11.93 CLDN1 CLDN3 CLDN7
8
Show member pathways
11.84 CTNNB1 KLK3 PIK3CA
9 11.81 CLDN1 CLDN3 CLDN7
10
Show member pathways
11.77 CLDN1 CLDN3 CLDN7 CTNNB1
11 11.68 CLDN1 CLDN3 CLDN7 PIK3CA
12
Show member pathways
11.6 CLDN1 CLDN3 CLDN7 CTNNB1 PIK3CA
13
Show member pathways
11.56 CTNNB1 PIK3CA
14 11.55 CTNNB1 KLK3
15 11.55 CLDN1 CLDN3 CTNNB1 KLK3
16 11.45 CTNNB1 PIK3CA
17 11.44 CLDN1 CTNNB1
18 11.31 CTNNB1 KLK3
19 11.09 CLDN1 CLDN3 CTNNB1
20 11.07 CTNNB1 PIK3CA
21 11.05 CTNNB1 PIK3CA
22 10.94 CLDN1 CTNNB1 PIK3CA

GO Terms for Prostate Transitional Cell Carcinoma

Cellular components related to Prostate Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell junction GO:0030054 9.62 CLDN1 CLDN3 CLDN7 CTNNB1
2 basolateral plasma membrane GO:0016323 9.33 CLDN1 CLDN7 CTNNB1
3 apicolateral plasma membrane GO:0016327 9.26 CLDN3 CLDN7
4 bicellular tight junction GO:0005923 9.26 CLDN1 CLDN3 CLDN7 CTNNB1
5 lateral plasma membrane GO:0016328 8.92 CLDN1 CLDN3 CLDN7 CTNNB1

Biological processes related to Prostate Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein heterooligomerization GO:0051291 9.32 CLDN1 CLDN3
2 bicellular tight junction assembly GO:0070830 9.26 CLDN1 CLDN3
3 vasculature development GO:0001944 9.16 CTNNB1 PIK3CA
4 response to ethanol GO:0045471 9.13 CLDN1 CLDN3 CLDN7
5 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules GO:0016338 8.8 CLDN1 CLDN3 CLDN7

Molecular functions related to Prostate Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 8.8 CLDN1 CLDN3 CLDN7

Sources for Prostate Transitional Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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