MCID: PRS027
MIFTS: 26

Prostate Transitional Cell Carcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Prostate Transitional Cell Carcinoma

MalaCards integrated aliases for Prostate Transitional Cell Carcinoma:

Name: Prostate Transitional Cell Carcinoma 12 15
Transitional Cell Carcinoma of Prostate 12
Primary Prostate Urothelial Carcinoma 71

Classifications:



External Ids:

Disease Ontology 12 DOID:4011
UMLS 71 C1514430

Summaries for Prostate Transitional Cell Carcinoma

Disease Ontology : 12 A prostate carcinoma that derives from transitional epithelial cells.

MalaCards based summary : Prostate Transitional Cell Carcinoma, also known as transitional cell carcinoma of prostate, is related to adrenomyeloneuropathy and pancreatoblastoma. An important gene associated with Prostate Transitional Cell Carcinoma is CLDN7 (Claudin 7), and among its related pathways/superpathways are Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases and Tight junction. Affiliated tissues include prostate and lymph node, and related phenotype is liver/biliary system.

Related Diseases for Prostate Transitional Cell Carcinoma

Diseases related to Prostate Transitional Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 adrenomyeloneuropathy 10.3 SLC25A17 AMACR
2 pancreatoblastoma 10.2 CLDN7 CLDN3
3 lactase deficiency, congenital 10.2 CLDN7 CLDN3 CLDN1
4 nephrogenic adenoma 10.2 KLK3 AMACR
5 urethra adenocarcinoma 10.2 KLK3 AMACR
6 wolffian duct adenoma 10.2 KLK3 AMACR
7 urethra cancer 10.2 KLK3 AMACR
8 transitional cell carcinoma 10.2
9 female urethral cancer 10.2 KLK3 AMACR
10 urethral diverticulum 10.2 KLK3 AMACR
11 bladder lateral wall cancer 10.2 KLK3 AMACR
12 refsum disease, classic 10.1 SLC25A17 AMACR ABCD3
13 bladder adenocarcinoma 10.1 KLK3 AMACR
14 seminal vesicle adenocarcinoma 10.1 KLK3 AMACR
15 papillary adenoma 10.1 KRT5 AMACR
16 prostatic hypertrophy 10.1
17 rare tumor 10.1
18 congenital bile acid synthesis defect 10.1 AMACR ABCD3
19 bladder cancer 10.0
20 in situ carcinoma 10.0
21 eccrine papillary adenocarcinoma 10.0 KRT5 KLK3
22 prostate adenoid cystic carcinoma 10.0 KLK3 AR
23 prostate leiomyoma 10.0 KLK3 AR
24 epididymis adenocarcinoma 10.0 KRT5 KLK3
25 epididymis cancer 10.0 KRT5 KLK3
26 prostate calculus 10.0 KLK3 AR
27 nodular prostate 10.0 KLK3 AR
28 bronchiectasis 3 10.0 KLK3 AR
29 prostatic hyperplasia, benign 10.0 KLK3 AR
30 bladder sarcoma 10.0 KRT5 KLK3
31 prostate neuroendocrine neoplasm 10.0 KLK3 AR
32 vulvar apocrine adenocarcinoma 9.9 KRT5 AR
33 apocrine adenocarcinoma 9.9 KRT5 AR
34 male urethral cancer 9.9 KRT5 KLK3 AMACR
35 male reproductive organ benign neoplasm 9.9 KLK3 AR
36 nephrogenic adenoma of the urethra 9.9 KRT5 KLK3 AMACR
37 urethral benign neoplasm 9.9 KRT5 KLK3 AMACR
38 urethra clear cell adenocarcinoma 9.9 KRT5 KLK3 AMACR
39 apocrine sweat gland neoplasm 9.9 KRT5 AR
40 prostatic acinar adenocarcinoma 9.9 KLK3 AR AMACR
41 prostatic adenoma 9.9 KLK3 AR
42 paget disease, extramammary 9.9 KRT5 AR
43 withdrawal disorder 9.9 KLK3 AR
44 suppression of tumorigenicity 12 9.8 KLK3 AR AMACR
45 androgenic alopecia 9.8 KLK3 AR
46 ductal carcinoma in situ 9.8 KRT5 CLDN7 AR
47 sebaceous adenocarcinoma 9.8 KRT5 AR
48 sweat gland cancer 9.7 KRT5 AR
49 sweat gland disease 9.6 KRT5 AR

Graphical network of the top 20 diseases related to Prostate Transitional Cell Carcinoma:



Diseases related to Prostate Transitional Cell Carcinoma

Symptoms & Phenotypes for Prostate Transitional Cell Carcinoma

MGI Mouse Phenotypes related to Prostate Transitional Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.1 ABCC3 ABCD3 AMACR AMFR AR MTA2

Drugs & Therapeutics for Prostate Transitional Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Prostate Transitional Cell Carcinoma

Genetic Tests for Prostate Transitional Cell Carcinoma

Anatomical Context for Prostate Transitional Cell Carcinoma

MalaCards organs/tissues related to Prostate Transitional Cell Carcinoma:

40
Prostate, Lymph Node

Publications for Prostate Transitional Cell Carcinoma

Articles related to Prostate Transitional Cell Carcinoma:

(show all 17)
# Title Authors PMID Year
1
Claudin-1, -3, -4 and -7 gene expression analyses in canine prostate carcinoma and mammary tissue derived cell lines. 61
26774145 2016
2
Diagnostic dilemma in histopathology report following robot assisted laparoscopic prostatectomy: tumour 'hide and seek'. 61
24061454 2013
3
[Pure primary prostate transitional cell carcinoma. A review of our series]. 61
15264680 2004
4
Morphological features correlation with serum tumour markers in prostatic carcinoma. 61
12971871 2003
5
Case report--Cutaneous metastasis from a primary transitional cell carcinoma of prostate. 61
12230282 2001
6
[Primary transitional cell carcinoma of prostate: a case report]. 61
10965459 2000
7
[Primary transitional carcinoma of the prostatic ductus]. 61
10965577 2000
8
Does prostate transitional cell carcinoma preclude orthotopic bladder reconstruction after radical cystoprostatectomy for bladder cancer? 61
9366327 1997
9
Is stage pT4a (D1) reliable in assessing transitional cell carcinoma involvement of the prostate in patients with a concurrent bladder cancer? A necessary distinction for contiguous or noncontiguous involvement. 61
7490845 1996
10
The application of laparoscopy to retroperitoneal surgery in urology. 61
8239734 1993
11
Transitional cell carcinoma of the prostate in patients undergoing radical cystoprostatectomy. 61
1729557 1992
12
Primary transitional cell carcinoma of prostate: case with lymph node metastasis eradicated by neoadjuvant methotrexate, vinblastine, doxorubicin, and cisplatin (M-VAC) therapy. 61
2368239 1990
13
[Usefulness of transurethral resection in cancer of the prostate]. 61
2639620 1989
14
Primary transitional cell carcinoma of prostate. 61
6506393 1984
15
Transitional cell carcinoma of prostate. 61
1129899 1975
16
Transitional-cell carcinoma of prostate. An enigma. 61
4769516 1973
17
Primary transitional cell carcinoma of prostate gland: possible pathogenesis and relationship to reserve cell hyperplasia of prostatic periurethral ducts. 61
4179564 1969

Variations for Prostate Transitional Cell Carcinoma

Expression for Prostate Transitional Cell Carcinoma

Search GEO for disease gene expression data for Prostate Transitional Cell Carcinoma.

Pathways for Prostate Transitional Cell Carcinoma

Pathways related to Prostate Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.01 SOS1 CLDN7 CLDN3 CLDN1
2 11.77 CLDN7 CLDN3 CLDN1
3 11.67 CLDN7 CLDN3 CLDN1
4 11.52 KLK3 CLDN3 CLDN1
5
Show member pathways
11.08 CLDN7 CLDN3 CLDN1 ABCC3
6 11.05 SLC25A17 AMACR ABCD3
7 10.91 CLDN3 CLDN1

GO Terms for Prostate Transitional Cell Carcinoma

Cellular components related to Prostate Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peroxisome GO:0005777 9.5 SLC25A17 AMACR ABCD3
2 bicellular tight junction GO:0005923 9.43 CLDN7 CLDN3 CLDN1
3 apicolateral plasma membrane GO:0016327 9.37 CLDN7 CLDN3
4 tight junction GO:0070160 9.16 CLDN3 CLDN1
5 lateral plasma membrane GO:0016328 9.13 CLDN7 CLDN3 CLDN1
6 protein-containing complex GO:0032991 9.1 MTA2 KLK3 CLDN3 CLDN1 AR AMFR

Biological processes related to Prostate Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to ethanol GO:0045471 9.58 CLDN7 CLDN3 CLDN1
2 maintenance of permeability of blood-brain barrier GO:0035633 9.46 CLDN3 CLDN1
3 positive regulation of wound healing GO:0090303 9.43 CLDN3 CLDN1
4 epithelial cell morphogenesis GO:0003382 9.37 CLDN3 AR
5 bicellular tight junction assembly GO:0070830 9.33 CLDN7 CLDN3 CLDN1
6 regulation of systemic arterial blood pressure GO:0003073 9.32 KLK3 AR
7 positive regulation of bicellular tight junction assembly GO:1903348 9.26 CLDN3 CLDN1
8 cell junction maintenance GO:0034331 8.96 CLDN3 CLDN1
9 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules GO:0016338 8.8 CLDN7 CLDN3 CLDN1

Molecular functions related to Prostate Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 8.92 CRYBB2 CLDN7 CLDN3 CLDN1

Sources for Prostate Transitional Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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