Prostate Transitional Cell Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Prostate Transitional Cell Carcinoma

MalaCards integrated aliases for Prostate Transitional Cell Carcinoma:

Name: Prostate Transitional Cell Carcinoma ¹² ¹⁵

Transitional Cell Carcinoma of Prostate ¹²

Primary Prostate Urothelial Carcinoma ⁷³

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:4011

UMLS ⁷³ C1514430

Sources

Summaries for Prostate Transitional Cell Carcinoma

MalaCards based summary : Prostate Transitional Cell Carcinoma, also known as transitional cell carcinoma of prostate, is related to adult hepatocellular carcinoma and hemimegalencephaly. An important gene associated with Prostate Transitional Cell Carcinoma is PIK3CA (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha), and among its related pathways/superpathways are Integrin Pathway and Sertoli-Sertoli Cell Junction Dynamics. Affiliated tissues include prostate, and related phenotype is Increased cell death HMECs cells.

Sources

Related Diseases for Prostate Transitional Cell Carcinoma

Diseases related to Prostate Transitional Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 23)

#	Related Disease	Score	Top Affiliating Genes
1	adult hepatocellular carcinoma	10.3	CTNNB1 PIK3CA
2	hemimegalencephaly	10.3	CTNNB1 PIK3CA
3	ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3	10.2	CTNNB1 PIK3CA
4	epstein-barr virus-associated gastric carcinoma	10.2	CTNNB1 PIK3CA
5	anaplastic thyroid cancer	10.2	CTNNB1 PIK3CA
6	female reproductive organ cancer	10.1	CTNNB1 PIK3CA
7	prostate adenoid cystic carcinoma	10.1	KLK3 PIK3CA
8	respiratory system cancer	10.1	CTNNB1 PIK3CA
9	prostate squamous cell carcinoma	10.1	KLK3 PIK3CA
10	uterine carcinosarcoma	10.0	CTNNB1 PIK3CA
11	prostatitis	10.0
12	transitional cell carcinoma	10.0
13	cystitis cystica	10.0	CTNNB1 KLK3
14	urinary tract obstruction	10.0	KLK3 PIK3CA
15	gastrointestinal system cancer	9.9	CTNNB1 PIK3CA
16	adrenocortical carcinoma, hereditary	9.8	CTNNB1 PIK3CA
17	bladder cancer	9.8
18	cell type cancer	9.7	CTNNB1 KLK3
19	suppression of tumorigenicity 12	9.6	CTNNB1 KLK3 PIK3CA
20	bladder urothelial carcinoma	9.6	CTNNB1 KLK3 PIK3CA
21	pancreas adenocarcinoma	9.6	CTNNB1 PIK3CA
22	adamantinoma of long bones	9.5	CTNNB1 KLK3 PIK3CA
23	gastric adenocarcinoma	9.3	CLDN7 CTNNB1 PIK3CA

Graphical network of the top 20 diseases related to Prostate Transitional Cell Carcinoma:

Sources

Symptoms & Phenotypes for Prostate Transitional Cell Carcinoma

GenomeRNAi Phenotypes related to Prostate Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased cell death HMECs cells	GR00103-A-0	8.92	CLDN1 CTNNB1 KLK3 PIK3CA

Sources

Drugs & Therapeutics for Prostate Transitional Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Prostate Transitional Cell Carcinoma

Sources

Genetic Tests for Prostate Transitional Cell Carcinoma

Sources

Anatomical Context for Prostate Transitional Cell Carcinoma

MalaCards organs/tissues related to Prostate Transitional Cell Carcinoma:

⁴¹

Prostate

Sources

Publications for Prostate Transitional Cell Carcinoma

Articles related to Prostate Transitional Cell Carcinoma:

#	Title	Authors	Year
1	Prostatic transitional cell carcinoma: pathologic features and clinical management. ( 18028024 )	Shen S.S....Lerner S.P.	2007
2	Changes of phenotypic expression of prostatic antigen in secondary transitional cell carcinoma of the prostate: evidence for induction phenomenon as a mechanism for acquisition of prostatic antigens in prostatic transitional cell carcinoma. ( 11351346 )	Mai K.T....Farmer J.	2001
3	Does prostate transitional cell carcinoma preclude orthotopic bladder reconstruction after radical cystoprostatectomy for bladder cancer? ( 9366327 )	Iselin C.E....Paulson D.F.	1997

Sources

Genes for Prostate Transitional Cell Carcinoma

Genes related to Prostate Transitional Cell Carcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	18.06	GeneCards inferred via : Variants (show sections)
2	CTNNB1	Catenin Beta 1	Protein Coding	17.71	GeneCards inferred via : Variants (show sections)
3	CLDN1	Claudin 1	Protein Coding	16.15	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	KLK3	Kallikrein Related Peptidase 3	Protein Coding	13.9	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	CLDN7	Claudin 7	Protein Coding	6.07	DISEASES inferred ¹⁵
6	CLDN3	Claudin 3	Protein Coding	5.83	DISEASES inferred ¹⁵

Sources

Variations for Prostate Transitional Cell Carcinoma

Sources

Expression for Prostate Transitional Cell Carcinoma

Search GEO for disease gene expression data for Prostate Transitional Cell Carcinoma.

Sources

Pathways for Prostate Transitional Cell Carcinoma

Pathways related to Prostate Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 22)

#	Super pathways	Score	Top Affiliating Genes
1	Integrin Pathway ⁶⁴ Show member pathways FAK1 Signaling ⁶⁴ GnRH Signaling ⁶⁴ Inhibition of Angiogenesis by TSP1 ⁶⁴ Transendothelial Migration of Leukocytes ⁶⁴ UPA-UPAR Pathway ⁶⁴	12.99	CLDN1 CLDN3 CLDN7 CTNNB1 PIK3CA
2	Sertoli-Sertoli Cell Junction Dynamics ⁶⁴ Show member pathways Epithelial Tight Junctions ⁶⁴ Germ Cell-Sertoli Cell Junction Dynamics ⁶⁴	12.6	CLDN1 CLDN3 CLDN7 CTNNB1
3	Endometrial cancer ³⁷ Show member pathways Acute myeloid leukemia ³⁷ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁶ Chronic myeloid leukemia ³⁷ Colorectal cancer ³⁷ Pancreatic cancer ³⁷ Prostate cancer ³⁷ Signal transduction PTEN pathway ²² Thyroid cancer ³⁷	12.53	CTNNB1 KLK3 PIK3CA
4	Pathways in cancer ³⁷	12.48	CTNNB1 KLK3 PIK3CA
5	Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases ²² Show member pathways Cell adhesion Integrin-mediated cell adhesion and migration ²² Cell adhesion Tight junctions ²² Cytoskeleton remodeling Integrin outside-in signaling ²² Development MAG-dependent inhibition of neurite outgrowth ²²	12.29	CLDN1 CLDN3 CLDN7 CTNNB1
6	Cell junction organization ⁶⁶ Show member pathways Adherens junctions interactions ⁶⁶ Cell-Cell communication ⁶⁶ Cell-cell junction organization ⁶⁶ Cell-extracellular matrix interactions ⁶⁶ DSCAM interactions ⁶⁶ Localization of the PINCH-ILK-PARVIN complex to focal adhesions ⁶⁶ Nectin/Necl trans heterodimerization ⁶⁶ Regulation of cytoskeletal remodeling and cell spreading by IPP complex components ⁶⁶ Signal regulatory protein (SIRP) family interactions ⁶⁶ Tight junction interactions ⁶⁶ Type I hemidesmosome assembly ⁶⁶	11.97	CLDN1 CLDN3 CLDN7 CTNNB1 PIK3CA
7	Tight junction ³⁷	11.93	CLDN1 CLDN3 CLDN7
8	Transcription Androgen Receptor nuclear signaling ²² Show member pathways Translation Non-genomic (rapid) action of Androgen Receptor ²²	11.84	CTNNB1 KLK3 PIK3CA
9	Cell adhesion molecules (CAMs) ³⁷	11.81	CLDN1 CLDN3 CLDN7
10	Blood-Brain Barrier and Immune Cell Transmigration: Pathways Overview ⁶⁵ Show member pathways Blood-Brain Barrier Pathway: Anatomy ⁶⁵	11.77	CLDN1 CLDN3 CLDN7 CTNNB1
11	Hepatitis C ³⁷	11.68	CLDN1 CLDN3 CLDN7 PIK3CA
12	Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways ⁶⁵ Show member pathways Blood-Brain Barrier and Immune Cell Transmigration: CCL2/MCP-1 Signaling Pathways ⁶⁵ Blood-Brain Barrier and Immune Cell Transmigration: ICAM-1/CD54 Signaling Pathways ⁶⁵ Blood-Brain Barrier and Immune Cell Transmigration: VEGF Signaling Pathways ⁶⁵ Leukocyte transendothelial migration ³⁷	11.6	CLDN1 CLDN3 CLDN7 CTNNB1 PIK3CA
13	Signaling events mediated by VEGFR1 and VEGFR2 ¹ Show member pathways VEGFR1 specific signals ¹	11.56	CTNNB1 PIK3CA
14	Androgen receptor signaling pathway ¹	11.55	CTNNB1 KLK3
15	Adhesion ⁴	11.55	CLDN1 CLDN3 CTNNB1 KLK3
16	Bacterial invasion of epithelial cells ³⁷	11.45	CTNNB1 PIK3CA
17	Primary Focal Segmental Glomerulosclerosis FSGS ¹	11.44	CLDN1 CTNNB1
18	Coregulation of Androgen receptor activity ¹	11.31	CTNNB1 KLK3
19	Cell adhesion_Endothelial cell contacts by junctional mechanisms ²²	11.09	CLDN1 CLDN3 CTNNB1
20	E-cadherin signaling in the nascent adherens junction ¹	11.07	CTNNB1 PIK3CA
21	N-cadherin signaling events ¹	11.05	CTNNB1 PIK3CA
22	Nectin adhesion pathway ¹	10.94	CLDN1 CTNNB1 PIK3CA

Sources

GO Terms for Prostate Transitional Cell Carcinoma

Cellular components related to Prostate Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell junction	GO:0030054	9.62	CLDN1 CLDN3 CLDN7 CTNNB1
2	basolateral plasma membrane	GO:0016323	9.33	CLDN1 CLDN7 CTNNB1
3	apicolateral plasma membrane	GO:0016327	9.26	CLDN3 CLDN7
4	bicellular tight junction	GO:0005923	9.26	CLDN1 CLDN3 CLDN7 CTNNB1
5	lateral plasma membrane	GO:0016328	8.92	CLDN1 CLDN3 CLDN7 CTNNB1

Biological processes related to Prostate Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein heterooligomerization	GO:0051291	9.32	CLDN1 CLDN3
2	bicellular tight junction assembly	GO:0070830	9.26	CLDN1 CLDN3
3	vasculature development	GO:0001944	9.16	CTNNB1 PIK3CA
4	response to ethanol	GO:0045471	9.13	CLDN1 CLDN3 CLDN7
5	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules	GO:0016338	8.8	CLDN1 CLDN3 CLDN7

Molecular functions related to Prostate Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	structural molecule activity	GO:0005198	8.8	CLDN1 CLDN3 CLDN7

Sources

Sources for Prostate Transitional Cell Carcinoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia