Prostate Transitional Cell Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Prostate Transitional Cell Carcinoma

MalaCards integrated aliases for Prostate Transitional Cell Carcinoma:

Name: Prostate Transitional Cell Carcinoma ¹² ¹⁵

Transitional Cell Carcinoma of Prostate ¹²

Primary Prostate Urothelial Carcinoma ⁷³

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:4011

UMLS ⁷³ C1514430

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Summaries for Prostate Transitional Cell Carcinoma

Disease Ontology : ¹² A prostate carcinoma that derives from transitional epithelial cells.

MalaCards based summary : Prostate Transitional Cell Carcinoma, also known as transitional cell carcinoma of prostate, is related to transitional cell carcinoma and adult hepatocellular carcinoma. An important gene associated with Prostate Transitional Cell Carcinoma is PIK3CA (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha), and among its related pathways/superpathways are Integrin Pathway and Sertoli-Sertoli Cell Junction Dynamics. Affiliated tissues include prostate, bone and thyroid, and related phenotype is Increased cell death HMECs cells.

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Related Diseases for Prostate Transitional Cell Carcinoma

Diseases related to Prostate Transitional Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 24)

#	Related Disease	Score	Top Affiliating Genes
1	transitional cell carcinoma	10.1
2	adult hepatocellular carcinoma	10.1	CTNNB1 PIK3CA
3	mast-cell leukemia	10.1	CTNNB1 PIK3CA
4	hemimegalencephaly	10.1	CTNNB1 PIK3CA
5	epstein-barr virus-associated gastric carcinoma	10.1	CTNNB1 PIK3CA
6	uterine anomalies	10.1	CTNNB1 PIK3CA
7	carcinosarcoma	10.1	CTNNB1 PIK3CA
8	anaplastic thyroid cancer	10.1	CTNNB1 PIK3CA
9	respiratory system cancer	10.0	CTNNB1 PIK3CA
10	prostate adenoid cystic carcinoma	10.0	KLK3 PIK3CA
11	uterine carcinosarcoma	10.0	CTNNB1 PIK3CA
12	intestinal disease	10.0	CTNNB1 PIK3CA
13	urinary tract obstruction	10.0	KLK3 PIK3CA
14	cystitis cystica	10.0	CTNNB1 KLK3
15	gastrointestinal system cancer	10.0	CTNNB1 PIK3CA
16	male reproductive organ cancer	10.0	CTNNB1 KLK3
17	reproductive system disease	9.9	CTNNB1 KLK3
18	bladder cancer	9.9
19	suppression of tumorigenicity 12	9.9	CTNNB1 KLK3 PIK3CA
20	bladder urothelial carcinoma	9.9	CTNNB1 KLK3 PIK3CA
21	adrenocortical carcinoma, hereditary	9.9	CTNNB1 PIK3CA
22	adamantinoma of long bones	9.9	CTNNB1 KLK3 PIK3CA
23	endometrial cancer	9.7	CLDN3 CTNNB1 PIK3CA
24	gastric adenocarcinoma	9.6	CLDN3 CLDN7 CTNNB1 PIK3CA

Graphical network of the top 20 diseases related to Prostate Transitional Cell Carcinoma:

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Symptoms & Phenotypes for Prostate Transitional Cell Carcinoma

GenomeRNAi Phenotypes related to Prostate Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased cell death HMECs cells	GR00103-A-0	8.92	CLDN1 CTNNB1 KLK3 PIK3CA

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Drugs & Therapeutics for Prostate Transitional Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Prostate Transitional Cell Carcinoma

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Genetic Tests for Prostate Transitional Cell Carcinoma

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Anatomical Context for Prostate Transitional Cell Carcinoma

MalaCards organs/tissues related to Prostate Transitional Cell Carcinoma:

⁴¹

Prostate, Bone, Thyroid

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Publications for Prostate Transitional Cell Carcinoma

Articles related to Prostate Transitional Cell Carcinoma:

#	Title	Authors	Year
1	Does prostate transitional cell carcinoma preclude orthotopic bladder reconstruction after radical cystoprostatectomy for bladder cancer? ( 9366327 )	Iselin CE...Paulson DF	1997

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Genes for Prostate Transitional Cell Carcinoma

Genes related to Prostate Transitional Cell Carcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	17.98	GeneCards inferred via : Variants (show sections)
2	CTNNB1	Catenin Beta 1	Protein Coding	17.63	GeneCards inferred via : Variants (show sections)
3	CLDN1	Claudin 1	Protein Coding	16	DISEASES inferred ¹⁵
4	KLK3	Kallikrein Related Peptidase 3	Protein Coding	13.72	DISEASES inferred ¹⁵
5	CLDN7	Claudin 7	Protein Coding	5.91	DISEASES inferred ¹⁵
6	CLDN3	Claudin 3	Protein Coding	5.69	DISEASES inferred ¹⁵

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Variations for Prostate Transitional Cell Carcinoma

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Expression for Prostate Transitional Cell Carcinoma

Search GEO for disease gene expression data for Prostate Transitional Cell Carcinoma.

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Pathways for Prostate Transitional Cell Carcinoma

Pathways related to Prostate Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 23)

#	Super pathways	Score	Top Affiliating Genes
1	Integrin Pathway ⁶⁴ Show member pathways FAK1 Signaling ⁶⁴ GnRH Signaling ⁶⁴ Inhibition of Angiogenesis by TSP1 ⁶⁴ Transendothelial Migration of Leukocytes ⁶⁴ UPA-UPAR Pathway ⁶⁴	13.01	CLDN1 CLDN3 CLDN7 CTNNB1 PIK3CA
2	Sertoli-Sertoli Cell Junction Dynamics ⁶⁴ Show member pathways Epithelial Tight Junctions ⁶⁴ Germ Cell-Sertoli Cell Junction Dynamics ⁶⁴	12.61	CLDN1 CLDN3 CLDN7 CTNNB1
3	Endometrial cancer ³⁷ Show member pathways Acute myeloid leukemia ³⁷ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁶ Chronic myeloid leukemia ³⁷ Colorectal cancer ³⁷ Pancreatic cancer ³⁷ Prostate cancer ³⁷ Signal transduction PTEN pathway ²² Thyroid cancer ³⁷	12.53	CTNNB1 KLK3 PIK3CA
4	Pathways in cancer ³⁷	12.49	CTNNB1 KLK3 PIK3CA
5	Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases ²² Show member pathways Cell adhesion Integrin-mediated cell adhesion and migration ²² Cell adhesion Tight junctions ²² Cytoskeleton remodeling Integrin outside-in signaling ²² Development MAG-dependent inhibition of neurite outgrowth ²²	12.31	CLDN1 CLDN3 CLDN7 CTNNB1
6	Cell junction organization ⁶⁶ Show member pathways Adherens junctions interactions ⁶⁶ Cell-Cell communication ⁶⁶ Cell-cell junction organization ⁶⁶ Cell-extracellular matrix interactions ⁶⁶ DSCAM interactions ⁶⁶ Localization of the PINCH-ILK-PARVIN complex to focal adhesions ⁶⁶ Nectin/Necl trans heterodimerization ⁶⁶ Regulation of cytoskeletal remodeling and cell spreading by IPP complex components ⁶⁶ Signal regulatory protein (SIRP) family interactions ⁶⁶ Tight junction interactions ⁶⁶ Type I hemidesmosome assembly ⁶⁶	11.97	CLDN1 CLDN3 CLDN7 CTNNB1 PIK3CA
7	Tight junction ³⁷	11.94	CLDN1 CLDN3 CLDN7
8	G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins ²² Show member pathways G-protein signaling G-Protein alpha-12 signaling pathway ²²	11.91	CLDN1 CLDN3 CLDN7 CTNNB1 PIK3CA
9	Transcription Androgen Receptor nuclear signaling ²² Show member pathways Translation Non-genomic (rapid) action of Androgen Receptor ²²	11.85	CTNNB1 KLK3 PIK3CA
10	Cell adhesion molecules (CAMs) ³⁷	11.83	CLDN1 CLDN3 CLDN7
11	Blood-Brain Barrier Pathway: Anatomy ⁶⁵ Show member pathways Blood-Brain Barrier and Immune Cell Transmigration: Pathways Overview ⁶⁵	11.77	CLDN1 CLDN3 CLDN7 CTNNB1
12	Hepatitis C ³⁷	11.68	CLDN1 CLDN3 CLDN7 PIK3CA
13	Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways ⁶⁵ Show member pathways Blood-Brain Barrier and Immune Cell Transmigration: CCL2/MCP-1 Signaling Pathways ⁶⁵ Blood-Brain Barrier and Immune Cell Transmigration: ICAM-1/CD54 Signaling Pathways ⁶⁵ Blood-Brain Barrier and Immune Cell Transmigration: VEGF Signaling Pathways ⁶⁵ Leukocyte transendothelial migration ³⁷	11.6	CLDN1 CLDN3 CLDN7 CTNNB1 PIK3CA
14	Signaling events mediated by VEGFR1 and VEGFR2 ¹ Show member pathways VEGFR1 specific signals ¹	11.57	CTNNB1 PIK3CA
15	Androgen receptor signaling pathway ¹	11.56	CTNNB1 KLK3
16	Adhesion ⁴	11.55	CLDN1 CLDN3 CTNNB1 KLK3
17	Bacterial invasion of epithelial cells ³⁷	11.45	CTNNB1 PIK3CA
18	Primary Focal Segmental Glomerulosclerosis FSGS ¹	11.45	CLDN1 CTNNB1
19	Coregulation of Androgen receptor activity ¹	11.32	CTNNB1 KLK3
20	Cell adhesion_Endothelial cell contacts by junctional mechanisms ²²	11.11	CLDN1 CLDN3 CTNNB1
21	E-cadherin signaling in the nascent adherens junction ¹	11.08	CTNNB1 PIK3CA
22	N-cadherin signaling events ¹	11.07	CTNNB1 PIK3CA
23	Nectin adhesion pathway ¹	10.94	CLDN1 CTNNB1 PIK3CA

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GO Terms for Prostate Transitional Cell Carcinoma

Cellular components related to Prostate Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell junction	GO:0030054	9.56	CLDN1 CLDN3 CLDN7 CTNNB1
2	basolateral plasma membrane	GO:0016323	9.33	CLDN1 CLDN7 CTNNB1
3	lateral plasma membrane	GO:0016328	9.13	CLDN1 CLDN3 CTNNB1
4	bicellular tight junction	GO:0005923	8.92	CLDN1 CLDN3 CLDN7 CTNNB1

Biological processes related to Prostate Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein heterooligomerization	GO:0051291	9.26	CLDN1 CLDN3
2	bicellular tight junction assembly	GO:0070830	9.16	CLDN1 CLDN3
3	vasculature development	GO:0001944	8.96	CTNNB1 PIK3CA
4	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules	GO:0016338	8.8	CLDN1 CLDN3 CLDN7

Molecular functions related to Prostate Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	structural molecule activity	GO:0005198	8.8	CLDN1 CLDN3 CLDN7

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