MCID: PRS006
MIFTS: 26

Prostatic Acinar Adenocarcinoma

Categories: Cancer diseases, Reproductive diseases
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Aliases & Classifications for Prostatic Acinar Adenocarcinoma

MalaCards integrated aliases for Prostatic Acinar Adenocarcinoma:

Name: Prostatic Acinar Adenocarcinoma 11 14
Acinar Prostate Adenocarcinoma 71

Classifications:



External Ids:

Disease Ontology 11 DOID:3024
NCIt 49 C5596
UMLS 71 C1332139

Summaries for Prostatic Acinar Adenocarcinoma

MalaCards based summary: Prostatic Acinar Adenocarcinoma, also known as acinar prostate adenocarcinoma, is related to prostate cancer and suppression of tumorigenicity 12. An important gene associated with Prostatic Acinar Adenocarcinoma is AMACR (Alpha-Methylacyl-CoA Racemase), and among its related pathways/superpathways are Regulation of Androgen receptor activity and Coregulation of Androgen receptor activity. The drugs Formaldehyde and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include prostate, bone marrow and liver.

Related Diseases for Prostatic Acinar Adenocarcinoma

Diseases related to Prostatic Acinar Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Related Disease Score Top Affiliating Genes
1 prostate cancer 29.1 TMPRSS2 SLC45A3 NKX3-1 KLK3 FOLH1 AR
2 suppression of tumorigenicity 12 28.2 TMPRSS2 SYP SLC45A3 NKX3-1 KLK3 FOLH1
3 adenocarcinoma 10.4
4 seminal vesicle adenocarcinoma 10.2 KLK3 AMACR
5 prostatic urethral cancer 10.2 KLK3 AMACR
6 prostate lymphoma 10.2 KLK3 AMACR
7 female urethral cancer 10.2 KLK3 AMACR
8 male urethral cancer 10.2 KLK3 AMACR
9 cervical adenoid basal carcinoma 10.2 NKX3-1 KLK3
10 bladder adenocarcinoma 10.2 KLK3 AMACR
11 nodular prostate 10.2 KLK3 FOLH1
12 nephrogenic adenoma of urinary bladder 10.1 PAX8 AMACR
13 lymphocele 10.1 KLK3 FOLH1
14 bladder benign neoplasm 10.1 PAX8 AMACR
15 prostate adenoid cystic carcinoma 10.1 KLK3 AR
16 prostate leiomyoma 10.1 KLK3 AR
17 urethra cancer 10.1 PAX8 KLK3
18 prostate calculus 10.1 KLK3 AR
19 epithelioid type angiomyolipoma 10.1 PAX8 AMACR
20 metanephric adenoma 10.1 PAX8 AMACR
21 urethral diverticulum 10.1 PAX8 KLK3
22 rete testis neoplasm 10.1 PAX8 NKX3-1
23 glandular cystitis 10.1 PAX8 AMACR
24 rete testis adenocarcinoma 10.1 PAX8 NKX3-1
25 bladder clear cell adenocarcinoma 10.1 PAX8 AMACR
26 urethral stricture 10.1 KLK3 FOLH1
27 prostate carcinoma in situ 10.1 NKX3-1 AR
28 renal adenoma 10.1 PAX8 AMACR
29 clear cell adenocarcinoma 10.1 PAX8 KLK3
30 epididymis adenocarcinoma 10.1 PAX8 KLK3
31 epididymis cancer 10.1 PAX8 KLK3
32 male reproductive organ benign neoplasm 10.1 KLK3 AR
33 collecting duct carcinoma 10.1 PAX8 AMACR
34 prostatic adenoma 10.1 KLK3 AR
35 renal oncocytoma 10.1 PAX8 AMACR
36 bladder cancer 10.1
37 angiosarcoma 10.1
38 sarcoma 10.1
39 neuroendocrine tumor 10.1
40 kidney benign neoplasm 10.1 PAX8 AMACR
41 withdrawal disorder 10.0 KLK3 AR
42 vulvar sebaceous carcinoma 10.0 PAX8 AR
43 androgenic alopecia 10.0 TMPRSS2 AR
44 wolffian duct adenoma 10.0 PAX8 KLK3 AMACR
45 nephrogenic adenoma 10.0 PAX8 KLK3 AMACR
46 nephrogenic adenoma of the urethra 10.0 PAX8 KLK3 AMACR
47 aromatase excess syndrome 10.0 AR AMACR
48 urethral benign neoplasm 10.0 PAX8 KLK3 AMACR
49 adenosquamous prostate carcinoma 10.0 SYP KLK3
50 prostatitis 10.0 NKX3-1 KLK3 AR

Graphical network of the top 20 diseases related to Prostatic Acinar Adenocarcinoma:



Diseases related to Prostatic Acinar Adenocarcinoma

Symptoms & Phenotypes for Prostatic Acinar Adenocarcinoma

Drugs & Therapeutics for Prostatic Acinar Adenocarcinoma

Drugs for Prostatic Acinar Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Formaldehyde Approved, Vet_approved 50-00-0 712
2 Immunoglobulins
3 Antibodies

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 ERG Protein Expression in Prostatic Acinar Adenocarcinoma and Its Correlation With Clinicopathological Features Not yet recruiting NCT04825691

Search NIH Clinical Center for Prostatic Acinar Adenocarcinoma

Genetic Tests for Prostatic Acinar Adenocarcinoma

Anatomical Context for Prostatic Acinar Adenocarcinoma

Organs/tissues related to Prostatic Acinar Adenocarcinoma:

MalaCards : Prostate, Bone Marrow, Liver, Bone

Publications for Prostatic Acinar Adenocarcinoma

Articles related to Prostatic Acinar Adenocarcinoma:

(show all 41)
# Title Authors PMID Year
1
Prostatic Ductal Adenocarcinoma Controlled for Tumor Grade, Stage, and Margin Status Does Not Independently Influence the Likelihood of Biochemical Recurrence in Localized Prostate Cancer After Radical Prostatectomy. 62
34739539 2022
2
A Rare Case of Co-Existing Mucin-Producing Urothelial-Type Adenocarcinoma of the Prostate and Acinar Adenocarcinoma. 62
35903905 2022
3
Defining Diagnostic Criteria for Prostatic Ductal Adenocarcinoma at Multiparametric MRI. 62
35076303 2022
4
Multiple Origin and Tumor Heterogeneity of Prostatic Ductal Adenocarcinoma in the Han Chinese Population. 62
34788144 2021
5
68Ga-DOTATATE PET/CT Uptake in Prostate With an Incidental Finding of Prostatic Acinar Adenocarcinoma and Metastatic Neuroendocrine Cancer to the Liver. 62
34034323 2021
6
Pleomorphic giant cell carcinoma of prostate: Rare tumor with unique clinicopathological, immunohistochemical, and molecular features. 62
33640702 2021
7
Optimizing the diagnosis and management of ductal prostate cancer. 62
33824525 2021
8
Prostatic ductal adenocarcinoma variant predicts worse pathological and oncological outcomes: Insight from over 1000 consecutive patients from a large prospective uro-oncology registry. 62
33428259 2021
9
Skene's gland adenocarcinoma coexisting with infiltrating urothelial carcinoma of the urinary bladder. 62
34706525 2021
10
A Review Leveraging a Rare and Unusual Case of Basal Cell Carcinoma of the Prostate. 62
34035971 2021
11
Morphological and functional alterations of the prostate tissue during clinical progression in hormonally-naïve, hormonally-treated and castration-resistant patients with metastatic prostate cancer. 62
32963607 2020
12
Napsin A is a highly sensitive marker for nephrogenic adenoma: an immunohistochemical study with a specificity test in genitourinary tumors. 62
32561332 2020
13
Primary bladder angiosarcoma synchronous with prostatic acinar adenocarcinoma in an 82-year-old male. 62
34754928 2020
14
Pigs in a blanket: an unusual presentation of malignant ascites in prostatic adenocarcinoma. 62
31732542 2019
15
The Association of Invasive Cribriform Lesions With Adverse Prostatic Adenocarcinoma Outcomes: An Institutional Experience, Systematic Review, and Meta-analysis. 62
30702333 2019
16
Rare Variant of Carcinoma Prostate Masquerading as Benign Prostatic Hyperplasia. 62
31249766 2019
17
34BetaE12 and Alfa-Methylacyl Coenzyme A Racemase (AMACR) Antibodies Better Than p63 Antibody Distinguish Normal and Neoplastic Glands in Prostatic Tissue With Thermal Artifacts. 62
29346181 2019
18
Prognostic Significance of High Androgen Receptor Expression in Prostatic Acinar Adenocarcinoma 62
30912411 2019
19
ERG oncoprotein expression in prostatic acinar adenocarcinoma; clinicopathologic significance. 62
30658688 2019
20
Updates on Grading and Staging of Prostate Cancer. 62
30447840 2018
21
Skene's Glands Adenocarcinoma: A Series of 4 Cases. 62
29901570 2018
22
Prostate Ductal Adenocarcinoma. 62
28362706 2018
23
SOCS3 Immunohistochemical Expression Seems to Support the 2005 and 2014 International Society of Urological Pathology (ISUP) Modified Gleason Grading System. 62
28144985 2017
24
The benign mimickers of prostatic acinar adenocarcinoma. 62
27041929 2016
25
Increased androgen receptor gene copy number is associated with TMPRSS2-ERG rearrangement in prostatic small cell carcinoma. 62
24777847 2015
26
Models of neuroendocrine prostate cancer. 62
25349195 2015
27
Bone marrow metastasis of prostatic adenocarcinoma with post-treatment foamy-like changes: A diagnostic pitfall. 62
25553175 2014
28
The prognostic role of ERG immunopositivity in prostatic acinar adenocarcinoma: a study including 454 cases and review of the literature. 62
24406017 2014
29
Large gastrointestinal stromal tumor and advanced adenocarcinoma in the rectum coexistent with an incidental prostate carcinoma: A case report. 62
25052916 2014
30
Foamy gland carcinoma of the prostate in needle biopsy: incidence, Gleason grade, and comparative α-methylacyl-CoA racemase vs. ERG expression. 62
23797726 2013
31
Micropapillary carcinoma: new variant of prostatic acinar adenocarcinoma. 62
23106591 2012
32
[Results of karyometry of acinar adenocarcinoma of the prostate]. 62
23342659 2012
33
Foamy gland adenocarcinoma of the prostate: incidence, Gleason grade, and early clinical outcome. 62
22221706 2012
34
Selected common diagnostic problems in urologic pathology: perspectives from a large consult service in genitourinary pathology. 62
22458899 2012
35
Cystic prostatic ductal adenocarcinoma: an unusual presentation and cytological diagnosis. 62
22371914 2012
36
An 82-year-old Caucasian man with a ductal prostate adenocarcinoma with unusual cystoscopic appearance: a case report. 62
21223563 2011
37
The distribution of PAX-2 immunoreactivity in the prostate gland, seminal vesicle, and ejaculatory duct: comparison with prostatic adenocarcinoma and discussion of prostatic zonal embryogenesis. 62
20413145 2010
38
TMPRSS2-ERG gene fusions are infrequent in prostatic ductal adenocarcinomas. 62
19151660 2009
39
[Prostatic duct adenocarcinoma with pagetoid spread on the glans penis: a case report]. 62
17176876 2006
40
Carcinosarcoma of the prostate. Report of 21 cases. 62
8625205 1995
41
Papillary adenocarcinoma of prostate. 62
184573 1976

Variations for Prostatic Acinar Adenocarcinoma

Expression for Prostatic Acinar Adenocarcinoma

Search GEO for disease gene expression data for Prostatic Acinar Adenocarcinoma.

Pathways for Prostatic Acinar Adenocarcinoma

Pathways related to Prostatic Acinar Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.02 TMPRSS2 KLK3 AR
2 10.71 TMPRSS2 NKX3-1 KLK3 AR
3 10.7 NKX3-1 KLK3 AR

GO Terms for Prostatic Acinar Adenocarcinoma

Biological processes related to Prostatic Acinar Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 androgen receptor signaling pathway GO:0030521 9.56 NKX3-1 AR
2 metanephros development GO:0001656 9.5 PAX8 NKX3-1
3 urogenital system development GO:0001655 9.33 PAX8 NKX3-1
4 cellular response to steroid hormone stimulus GO:0071383 9.26 NKX3-1 AR
5 regulation of systemic arterial blood pressure GO:0003073 8.92 KLK3 AR

Sources for Prostatic Acinar Adenocarcinoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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