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MCID: PRS006
MIFTS: 33

Prostatic Acinar Adenocarcinoma

Categories: Cancer diseases, Reproductive diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Prostatic Acinar Adenocarcinoma

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MalaCards integrated aliases for Prostatic Acinar Adenocarcinoma:

Name: Prostatic Acinar Adenocarcinoma 12 15
Acinar Prostate Adenocarcinoma 72

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3024
NCIt 50 C5596
UMLS 72 C1332139
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Summaries for Prostatic Acinar Adenocarcinoma

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MalaCards based summary : Prostatic Acinar Adenocarcinoma, also known as acinar prostate adenocarcinoma, is related to suppression of tumorigenicity 12 and prostate sarcoma. An important gene associated with Prostatic Acinar Adenocarcinoma is AR (Androgen Receptor), and among its related pathways/superpathways are Pathways in cancer and Endometrial cancer. Affiliated tissues include prostate, bone and bone marrow, and related phenotypes are cellular and embryo

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Related Diseases for Prostatic Acinar Adenocarcinoma

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Diseases related to Prostatic Acinar Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 163)
# Related Disease Score Top Affiliating Genes
1 suppression of tumorigenicity 12 30.2 TMPRSS2 NKX3-1 KLK3 AR AMACR
2 prostate sarcoma 10.7 NKX3-1 KLK3
3 nodular prostate 10.7 KLK3 AR
4 bladder diverticulum 10.7 PAX2 AMACR
5 urethra clear cell adenocarcinoma 10.6 KLK3 AMACR
6 urethra adenocarcinoma 10.6 KLK3 AMACR
7 rete testis adenoma 10.6 PAX8 PAX2
8 childhood endodermal sinus tumor 10.6 PAX8 PAX2
9 morpheaform basal cell carcinoma 10.6 KRT20 AR
10 urethral benign neoplasm 10.5 KLK3 AMACR
11 adenocarcinoma 10.4
12 vaginal tubulovillous adenoma 10.4 KRT20 CDX2
13 vaginal adenoma 10.4 KRT20 CDX2
14 vaginal benign neoplasm 10.4 KRT20 CDX2
15 oncocytic breast carcinoma 10.4 KRT7 AR
16 clear cell papillary renal cell carcinoma 10.3 KRT7 AMACR
17 papillary adenoma 10.3 KRT7 AMACR
18 vulvar sarcoma 10.3 KRT7 AR
19 bile duct mucoepidermoid carcinoma 10.3 MUC5B KRT7
20 male reproductive organ benign neoplasm 10.3 WT1 KLK3
21 corneal abscess 10.3 KRT7 AR
22 cystic basal cell carcinoma 10.3 KRT7 KRT20
23 renal pelvis adenocarcinoma 10.3 PAX8 KRT7
24 malignant syringoma 10.3 KRT7 KRT20
25 transverse colon cancer 10.2 KRT7 KRT20
26 familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis 10.2 WT1 PAX2
27 sensory organ benign neoplasm 10.2 PAX8 KRT7
28 krukenberg carcinoma 10.2 KRT7 KRT20
29 eyelid carcinoma 10.2 KRT7 KRT20
30 papillary transitional carcinoma 10.2 KRT7 KRT20
31 small cell carcinoma of the bladder 10.2 KRT7 KRT20
32 lung acinar adenocarcinoma 10.2 KRT7 KRT20
33 linitis plastica 10.2 KRT7 KRT20
34 large intestine adenocarcinoma 10.2 KRT7 KRT20
35 endocervical carcinoma 10.2 PAX8 KRT7
36 villous adenoma 10.2 KRT20 KLK3 CDX2
37 adenoid squamous cell carcinoma 10.2 KRT7 KRT20
38 prostate embryonal rhabdomyosarcoma 10.2 KLK3 KIT
39 ovary neuroendocrine neoplasm 10.2 KRT7 CDX2
40 bile duct adenoma 10.2 KRT7 KRT20
41 bile duct cystadenocarcinoma 10.2 KRT7 KRT20
42 vulval paget's disease 10.2 KRT7 KRT20
43 anus adenocarcinoma 10.2 KRT7 CDX2
44 mucinous adenofibroma 10.2 KRT7 CDX2
45 papillary serous adenocarcinoma 10.1 KRT7 KRT20
46 prostate rhabdomyosarcoma 10.1 KLK3 KIT
47 bladder lymphoma 10.1 KRT7 KRT20
48 duodenum adenocarcinoma 10.1 KRT7 CDX2
49 meibomian cyst 10.1 KRT7 KRT20 AR
50 male reproductive organ cancer 10.1 TMPRSS2 NKX3-1 KLK3 AR AMACR

Graphical network of the top 20 diseases related to Prostatic Acinar Adenocarcinoma:



Diseases related to Prostatic Acinar Adenocarcinoma
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Symptoms & Phenotypes for Prostatic Acinar Adenocarcinoma

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MGI Mouse Phenotypes related to Prostatic Acinar Adenocarcinoma:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.29 AR CDX2 ERG KIT KRT7 MUC5B
2 embryo MP:0005380 10.24 AR CDX2 ERG KIT NKX3-1 PAX2
3 homeostasis/metabolism MP:0005376 10.21 AMACR AR CDX2 ERG KIT KRT7
4 growth/size/body region MP:0005378 10.2 AMACR AR CDX2 ERG KIT MUC5B
5 cardiovascular system MP:0005385 10.18 AR CDX2 ERG KIT PAX2 PAX8
6 endocrine/exocrine gland MP:0005379 10.18 AR CDX2 ERG KIT NKX3-1 PAX2
7 mortality/aging MP:0010768 10.18 AMACR AR CDX2 ERG KIT MUC5B
8 limbs/digits/tail MP:0005371 9.88 AR CDX2 KIT NKX3-1 PAX8 SATB2
9 neoplasm MP:0002006 9.87 AR CDX2 ERG KIT NKX3-1 TMPRSS2
10 normal MP:0002873 9.86 AR CDX2 ERG KIT PAX8 SOCS3
11 reproductive system MP:0005389 9.81 AR CDX2 ERG KIT NKX3-1 PAX2
12 respiratory system MP:0005388 9.5 ERG KIT MUC5B SATB2 SOCS3 TMPRSS2
13 skeleton MP:0005390 9.23 AR CDX2 ERG KIT NKX3-1 PAX8
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Drugs & Therapeutics for Prostatic Acinar Adenocarcinoma

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Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Initial Experience in Brazilian Single Center With High Intensity Focalized Ultrasound (HIFU) Prostate Cancer Therapy: Morbidity, Oncological and Functional Outcomes. Active, not recruiting NCT03255135

Search NIH Clinical Center for Prostatic Acinar Adenocarcinoma

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Genetic Tests for Prostatic Acinar Adenocarcinoma

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Anatomical Context for Prostatic Acinar Adenocarcinoma

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MalaCards organs/tissues related to Prostatic Acinar Adenocarcinoma:

41
Prostate, Bone, Bone Marrow
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Publications for Prostatic Acinar Adenocarcinoma

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Articles related to Prostatic Acinar Adenocarcinoma:

(show all 32)
# Title Authors PMID Year
1
The Association of Invasive Cribriform Lesions With Adverse Prostatic Adenocarcinoma Outcomes: An Institutional Experience, Systematic Review, and Meta-analysis. 38
30702333 2019
2
34BetaE12 and Alfa-Methylacyl Coenzyme A Racemase (AMACR) Antibodies Better Than p63 Antibody Distinguish Normal and Neoplastic Glands in Prostatic Tissue With Thermal Artifacts. 38
29346181 2019
3
Rare Variant of Carcinoma Prostate Masquerading as Benign Prostatic Hyperplasia. 38
31249766 2019
4
Prognostic Significance of High Androgen Receptor Expression in Prostatic Acinar Adenocarcinoma 38
30912411 2019
5
ERG oncoprotein expression in prostatic acinar adenocarcinoma; clinicopathologic significance. 38
30658688 2019
6
Updates on Grading and Staging of Prostate Cancer. 38
30447840 2018
7
Skene's Glands Adenocarcinoma: A Series of 4 Cases. 38
29901570 2018
8
Prostatic Adenocarcinoma With Focal Pleomorphic Giant Cell Features: A Series of 30 Cases. 38
29944471 2018
9
Prostate Ductal Adenocarcinoma. 38
28362706 2018
10
Loss of PSMA Expression in Non-neuroendocrine Dedifferentiated Acinar Prostate Cancer. 38
29659395 2018
11
SOCS3 Immunohistochemical Expression Seems to Support the 2005 and 2014 International Society of Urological Pathology (ISUP) Modified Gleason Grading System. 38
28144985 2017
12
Acinar Adenocarcinoma of Prostate with Predominant Ttf-1 Positive Intraductal Component. 38
28044303 2017
13
The benign mimickers of prostatic acinar adenocarcinoma. 38
27041929 2016
14
Increased androgen receptor gene copy number is associated with TMPRSS2-ERG rearrangement in prostatic small cell carcinoma. 38
24777847 2015
15
Models of neuroendocrine prostate cancer. 38
25349195 2015
16
Bone marrow metastasis of prostatic adenocarcinoma with post-treatment foamy-like changes: A diagnostic pitfall. 38
25553175 2014
17
Pseudopapillary features in prostatic adenocarcinoma mimicking urothelial carcinoma: a diagnostic pitfall. 38
24503758 2014
18
The prognostic role of ERG immunopositivity in prostatic acinar adenocarcinoma: a study including 454 cases and review of the literature. 38
24406017 2014
19
Large gastrointestinal stromal tumor and advanced adenocarcinoma in the rectum coexistent with an incidental prostate carcinoma: A case report. 38
25052916 2014
20
Foamy gland carcinoma of the prostate in needle biopsy: incidence, Gleason grade, and comparative α-methylacyl-CoA racemase vs. ERG expression. 38
23797726 2013
21
Micropapillary carcinoma: new variant of prostatic acinar adenocarcinoma. 38
23106591 2012
22
[Results of karyometry of acinar adenocarcinoma of the prostate]. 38
23342659 2012
23
Foamy gland adenocarcinoma of the prostate: incidence, Gleason grade, and early clinical outcome. 38
22221706 2012
24
Selected common diagnostic problems in urologic pathology: perspectives from a large consult service in genitourinary pathology. 38
22458899 2012
25
A rare case of metastatic ductal type prostate adenocarcinoma presenting with syndrome of inappropriate secretion of antidiuretic hormone: a case report and review. 38
22842384 2012
26
Cystic prostatic ductal adenocarcinoma: an unusual presentation and cytological diagnosis. 38
22371914 2012
27
An 82-year-old Caucasian man with a ductal prostate adenocarcinoma with unusual cystoscopic appearance: a case report. 38
21223563 2011
28
The distribution of PAX-2 immunoreactivity in the prostate gland, seminal vesicle, and ejaculatory duct: comparison with prostatic adenocarcinoma and discussion of prostatic zonal embryogenesis. 38
20413145 2010
29
TMPRSS2-ERG gene fusions are infrequent in prostatic ductal adenocarcinomas. 38
19151660 2009
30
[Prostatic duct adenocarcinoma with pagetoid spread on the glans penis: a case report]. 38
17176876 2006
31
Carcinosarcoma of the prostate. Report of 21 cases. 38
8625205 1995
32
Papillary adenocarcinoma of prostate. 38
184573 1976
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Variations for Prostatic Acinar Adenocarcinoma

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Expression for Prostatic Acinar Adenocarcinoma

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Search GEO for disease gene expression data for Prostatic Acinar Adenocarcinoma.
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Pathways for Prostatic Acinar Adenocarcinoma

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Pathways related to Prostatic Acinar Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Pathways in cancer 37
12.49 PAX8 NKX3-1 KLK3 KIT AR
2
Endometrial cancer 37
Show member pathways
 11.91 TMPRSS2 PAX8 NKX3-1 KLK3 KIT ERG
3
Transcriptional misregulation in cancer 37
11.89 WT1 TMPRSS2 PAX8 ERG
4
Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.73 WT1 PAX2 CDX2
5
Regulation of Androgen receptor activity 1
11.13 TMPRSS2 KLK3 AR
6
Coregulation of Androgen receptor activity 1
11.01 TMPRSS2 NKX3-1 KLK3 AR
7
FOXA1 transcription factor network 1
Show member pathways
 10.99 NKX3-1 KLK3 AR
8
ID signaling pathway 1
10.61 PAX8 PAX2
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GO Terms for Prostatic Acinar Adenocarcinoma

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Biological processes related to Prostatic Acinar Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.97 WT1 PAX8 PAX2 NKX3-1 CDX2 AR
2 positive regulation of cell differentiation GO:0045597 9.73 SOCS3 CDX2 AR
3 branching involved in ureteric bud morphogenesis GO:0001658 9.72 WT1 PAX8 PAX2
4 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.66 PAX8 PAX2
5 prostate gland development GO:0030850 9.65 NKX3-1 AR
6 negative regulation of programmed cell death GO:0043069 9.65 PAX2 KIT
7 regulation of systemic arterial blood pressure GO:0003073 9.64 KLK3 AR
8 mesonephros development GO:0001823 9.64 PAX8 PAX2
9 cellular response to steroid hormone stimulus GO:0071383 9.63 NKX3-1 AR
10 mesenchymal to epithelial transition GO:0060231 9.62 WT1 PAX2
11 metanephric mesenchyme development GO:0072075 9.61 WT1 PAX2
12 cellular response to gonadotropin stimulus GO:0071371 9.61 WT1 PAX8
13 mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003337 9.6 PAX8 PAX2
14 regulation of metanephric nephron tubule epithelial cell differentiation GO:0072307 9.59 PAX8 PAX2
15 pronephros development GO:0048793 9.58 PAX8 PAX2
16 metanephric S-shaped body morphogenesis GO:0072284 9.58 WT1 PAX8
17 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0072108 9.54 PAX8 PAX2
18 metanephric nephron tubule formation GO:0072289 9.52 PAX8 PAX2
19 metanephric distal convoluted tubule development GO:0072221 9.51 PAX8 PAX2
20 transcription by RNA polymerase II GO:0006366 9.48 PAX2 CDX2
21 negative regulation of mesenchymal cell apoptotic process involved in metanephros development GO:1900212 9.46 PAX8 PAX2
22 male gonad development GO:0008584 9.46 WT1 NKX3-1 KIT AR
23 pronephric field specification GO:0039003 9.43 PAX8 PAX2
24 positive regulation of metanephric DCT cell differentiation GO:2000594 9.4 PAX8 PAX2
25 negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis GO:0072305 9.37 PAX8 PAX2
26 negative regulation of apoptotic process involved in metanephric nephron tubule development GO:1900218 9.32 PAX8 PAX2
27 negative regulation of apoptotic process involved in metanephric collecting duct development GO:1900215 9.26 PAX8 PAX2
28 urogenital system development GO:0001655 9.13 PAX8 PAX2 NKX3-1
29 metanephric epithelium development GO:0072207 8.8 WT1 PAX8 PAX2
30 regulation of transcription, DNA-templated GO:0006355 10.17 WT1 PAX8 PAX2 NKX3-1 ERG CDX2
31 multicellular organism development GO:0007275 10.13 SATB2 PAX8 PAX2 NKX3-1 ERG CDX2
32 positive regulation of transcription by RNA polymerase II GO:0045944 10.11 WT1 SATB2 PAX8 PAX2 NKX3-1 ERG
33 positive regulation of cell proliferation GO:0008284 10.02 PAX2 NKX3-1 KIT CDX2 AR

Molecular functions related to Prostatic Acinar Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.91 WT1 SATB2 PIN4 PAX8 PAX2 NKX3-1
2 DNA-binding transcription factor activity GO:0003700 9.85 WT1 PAX8 NKX3-1 ERG CDX2 AR
3 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.76 WT1 SATB2 PAX8 PAX2 NKX3-1 ERG
4 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.72 SATB2 PAX8 NKX3-1 ERG AR
5 transcription regulatory region DNA binding GO:0044212 9.35 WT1 PAX8 PAX2 NKX3-1 AR
6 sequence-specific DNA binding GO:0043565 9.17 WT1 SATB2 PAX8 NKX3-1 ERG CDX2
7 protein binding GO:0005515 10.28 WT1 TMPRSS2 SOCS3 SATB2 PIN4 PAX8
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Sources for Prostatic Acinar Adenocarcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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