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MCID: PRS006
MIFTS: 34

Prostatic Acinar Adenocarcinoma

Categories: Cancer diseases, Reproductive diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Prostatic Acinar Adenocarcinoma

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MalaCards integrated aliases for Prostatic Acinar Adenocarcinoma:

Name: Prostatic Acinar Adenocarcinoma 12 15
Acinar Prostate Adenocarcinoma 73

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3024
NCIt 50 C5596
UMLS 73 C1332139
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Summaries for Prostatic Acinar Adenocarcinoma

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MalaCards based summary : Prostatic Acinar Adenocarcinoma, also known as acinar prostate adenocarcinoma, is related to adenocarcinoma and prostate sarcoma. An important gene associated with Prostatic Acinar Adenocarcinoma is AMACR (Alpha-Methylacyl-CoA Racemase), and among its related pathways/superpathways are Endometrial cancer and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include prostate, lung and kidney, and related phenotypes are cellular and embryo

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Related Diseases for Prostatic Acinar Adenocarcinoma

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Diseases related to Prostatic Acinar Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 168)
# Related Disease Score Top Affiliating Genes
1 adenocarcinoma 10.3
2 prostate sarcoma 10.3 KLK3 NKX3-1
3 bladder diverticulum 10.3 AMACR PAX2
4 urethra adenocarcinoma 10.2 AMACR KLK3
5 urethra clear cell adenocarcinoma 10.2 AMACR KLK3
6 rete testis adenoma 10.2 PAX2 PAX8
7 childhood endodermal sinus tumor 10.2 PAX2 PAX8
8 urethral benign neoplasm 10.2 AMACR KLK3
9 clear cell papillary renal cell carcinoma 10.2 AMACR KRT7
10 papillary adenoma 10.2 AMACR KRT7
11 eccrine sweat gland neoplasm 10.2 KRT20 KRT7
12 thymus lipoma 10.2 KRT20 KRT7
13 mucinous cystadenocarcinoma 10.2 KRT20 KRT7
14 infiltrative basal cell carcinoma 10.2 KRT20 KRT7
15 cystadenofibroma 10.2 KRT20 KRT7
16 lymphoepithelioma-like carcinoma 10.2 KRT20 KRT7
17 vaginal benign neoplasm 10.2 CDX2 KRT20
18 vaginal adenoma 10.2 CDX2 KRT20
19 vaginal tubulovillous adenoma 10.2 CDX2 KRT20
20 bile duct mucoepidermoid carcinoma 10.1 KRT7 MUC5B
21 cystic basal cell carcinoma 10.1 KRT20 KRT7
22 renal pelvis adenocarcinoma 10.1 KRT7 PAX8
23 transverse colon cancer 10.1 KRT20 KRT7
24 duodenal disease 10.1 CDX2 KRT7
25 malignant syringoma 10.1 KRT20 KRT7
26 sensory organ benign neoplasm 10.1 KRT7 PAX8
27 papillary transitional carcinoma 10.1 KRT20 KRT7
28 eyelid carcinoma 10.1 KRT20 KRT7
29 krukenberg carcinoma 10.1 KRT20 KRT7
30 large intestine adenocarcinoma 10.1 KRT20 KRT7
31 linitis plastica 10.1 KRT20 KRT7
32 lung acinar adenocarcinoma 10.1 KRT20 KRT7
33 small cell carcinoma of the bladder 10.1 KRT20 KRT7
34 male reproductive organ cancer 10.1 AMACR KLK3 NKX3-1 TMPRSS2
35 male reproductive system disease 10.1 AMACR KLK3 NKX3-1 TMPRSS2
36 reproductive system disease 10.1 AMACR KLK3 NKX3-1 TMPRSS2
37 prostate disease 10.1 AMACR KLK3 NKX3-1 TMPRSS2
38 suppression of tumorigenicity 12 10.1 AMACR KLK3 NKX3-1 TMPRSS2
39 adenoid squamous cell carcinoma 10.1 KRT20 KRT7
40 endocervical carcinoma 10.1 KRT7 PAX8
41 ovary neuroendocrine neoplasm 10.1 CDX2 KRT7
42 vulval paget's disease 10.1 KRT20 KRT7
43 bile duct cystadenocarcinoma 10.1 KRT20 KRT7
44 bile duct adenoma 10.1 KRT20 KRT7
45 seminal vesicle tumor 10.1 KLK3 KRT7
46 mucinous adenofibroma 10.1 CDX2 KRT7
47 anus adenocarcinoma 10.1 CDX2 KRT7
48 meibomian cyst 10.1 KRT20 KRT7
49 bladder lymphoma 10.1 KRT20 KRT7
50 papillary serous adenocarcinoma 10.1 KRT20 KRT7

Graphical network of the top 20 diseases related to Prostatic Acinar Adenocarcinoma:



Diseases related to Prostatic Acinar Adenocarcinoma
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Symptoms & Phenotypes for Prostatic Acinar Adenocarcinoma

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MGI Mouse Phenotypes related to Prostatic Acinar Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.1 CDX2 KIT KRT7 MUC5B NKX3-1 PAX2
2 embryo MP:0005380 10.02 CDX2 KIT NKX3-1 PAX2 PAX8 SATB2
3 homeostasis/metabolism MP:0005376 9.96 AMACR CDX2 KIT KRT7 MUC5B NKX3-1
4 endocrine/exocrine gland MP:0005379 9.92 CDX2 KIT NKX3-1 PAX2 PAX8 SATB2
5 mortality/aging MP:0010768 9.9 AMACR CDX2 KIT MUC5B NKX3-1 PAX2
6 reproductive system MP:0005389 9.5 CDX2 KIT NKX3-1 PAX2 PAX8 TMPRSS2
7 respiratory system MP:0005388 9.1 KIT MUC5B SATB2 SOCS3 TMPRSS2 WT1
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Drugs & Therapeutics for Prostatic Acinar Adenocarcinoma

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Search Clinical Trials , NIH Clinical Center for Prostatic Acinar Adenocarcinoma

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Genetic Tests for Prostatic Acinar Adenocarcinoma

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Anatomical Context for Prostatic Acinar Adenocarcinoma

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MalaCards organs/tissues related to Prostatic Acinar Adenocarcinoma:

41
Prostate, Lung, Kidney, Ovary, Testis, Thymus, Appendix
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Publications for Prostatic Acinar Adenocarcinoma

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Articles related to Prostatic Acinar Adenocarcinoma:

# Title Authors Year
1
The benign mimickers of prostatic acinar adenocarcinoma. ( 27041929 )
2016
2
The prognostic role of ERG immunopositivity in prostatic acinar adenocarcinoma: a study including 454 cases and review of the literature. ( 24406017 )
2013
3
Micropapillary carcinoma: new variant of prostatic acinar adenocarcinoma. ( 23106591 )
2012
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Variations for Prostatic Acinar Adenocarcinoma

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Expression for Prostatic Acinar Adenocarcinoma

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Search GEO for disease gene expression data for Prostatic Acinar Adenocarcinoma.
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Pathways for Prostatic Acinar Adenocarcinoma

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Pathways related to Prostatic Acinar Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Endometrial cancer 37
Show member pathways
 12.1 KIT KLK3 NKX3-1 PAX8 TMPRSS2
2
Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.56 CDX2 PAX2 WT1
3
Coregulation of Androgen receptor activity 1
10.56 KLK3 NKX3-1 TMPRSS2
4
ID signaling pathway 1
10.36 PAX2 PAX8
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GO Terms for Prostatic Acinar Adenocarcinoma

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Biological processes related to Prostatic Acinar Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 transcription by RNA polymerase II GO:0006366 9.99 CDX2 PAX2 PAX8 SATB2 WT1
2 male gonad development GO:0008584 9.79 KIT NKX3-1 WT1
3 branching involved in ureteric bud morphogenesis GO:0001658 9.63 PAX2 PAX8 WT1
4 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.62 PAX2 PAX8
5 negative regulation of programmed cell death GO:0043069 9.62 KIT PAX2
6 mesonephros development GO:0001823 9.61 PAX2 PAX8
7 mesenchymal to epithelial transition GO:0060231 9.58 PAX2 WT1
8 cellular response to gonadotropin stimulus GO:0071371 9.58 PAX8 WT1
9 metanephric mesenchyme development GO:0072075 9.57 PAX2 WT1
10 mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003337 9.56 PAX2 PAX8
11 pronephros development GO:0048793 9.55 PAX2 PAX8
12 regulation of metanephric nephron tubule epithelial cell differentiation GO:0072307 9.54 PAX2 PAX8
13 metanephric S-shaped body morphogenesis GO:0072284 9.52 PAX8 WT1
14 metanephric distal convoluted tubule development GO:0072221 9.51 PAX2 PAX8
15 metanephric nephron tubule formation GO:0072289 9.49 PAX2 PAX8
16 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0072108 9.48 PAX2 PAX8
17 negative regulation of mesenchymal cell apoptotic process involved in metanephros development GO:1900212 9.43 PAX2 PAX8
18 negative regulation of apoptotic process involved in metanephric collecting duct development GO:1900215 9.4 PAX2 PAX8
19 negative regulation of apoptotic process involved in metanephric nephron tubule development GO:1900218 9.37 PAX2 PAX8
20 negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis GO:0072305 9.32 PAX2 PAX8
21 positive regulation of metanephric DCT cell differentiation GO:2000594 9.26 PAX2 PAX8
22 pronephric field specification GO:0039003 9.16 PAX2 PAX8
23 urogenital system development GO:0001655 9.13 NKX3-1 PAX2 PAX8
24 metanephric epithelium development GO:0072207 8.8 PAX2 PAX8 WT1
25 positive regulation of transcription, DNA-templated GO:0045893 10 CDX2 NKX3-1 PAX2 PAX8 WT1

Molecular functions related to Prostatic Acinar Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.97 KIT KLK3 KRT20 KRT7 MUC5B NKX3-1
2 sequence-specific DNA binding GO:0043565 9.35 CDX2 NKX3-1 PAX8 SATB2 WT1
3 transcription regulatory region DNA binding GO:0044212 8.92 NKX3-1 PAX2 PAX8 WT1
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Sources for Prostatic Acinar Adenocarcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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