Prostatic Acinar Adenocarcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Prostatic Acinar Adenocarcinoma

MalaCards integrated aliases for Prostatic Acinar Adenocarcinoma:

Name: Prostatic Acinar Adenocarcinoma ¹² ¹⁵

Acinar Prostate Adenocarcinoma ⁷³

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:3024

NCIt ⁵⁰ C5596

UMLS ⁷³ C1332139

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Summaries for Prostatic Acinar Adenocarcinoma

MalaCards based summary : Prostatic Acinar Adenocarcinoma, also known as acinar prostate adenocarcinoma, is related to bladder diverticulum and renal adenoma. An important gene associated with Prostatic Acinar Adenocarcinoma is TMPRSS2 (Transmembrane Serine Protease 2), and among its related pathways/superpathways are Endometrial cancer and FOXA1 transcription factor network. Affiliated tissues include prostate, and related phenotype is embryo.

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Related Diseases for Prostatic Acinar Adenocarcinoma

Diseases related to Prostatic Acinar Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)

#	Related Disease	Score	Top Affiliating Genes
1	bladder diverticulum	10.5	AMACR PAX2
2	renal adenoma	10.5	AMACR PAX2
3	urethra adenocarcinoma	10.5	AMACR KLK3
4	urethra clear cell adenocarcinoma	10.5	AMACR KLK3
5	urethral benign neoplasm	10.5	AMACR KLK3
6	seminal vesicle adenocarcinoma	10.5	KLK3 KRT20
7	ovarian mucinous adenocarcinoma	10.5	AMACR KRT20
8	urethral diverticulum	10.4	AMACR KLK3
9	villous adenoma	10.4	KLK3 KRT20
10	prostatic adenoma	10.4	AR KLK3
11	nodular prostate	10.3	AR KLK3
12	endocervical adenocarcinoma	10.3	KRT20 PAX2
13	prostatic hyperplasia, benign	10.3	AR KLK3
14	morpheaform basal cell carcinoma	10.3	AR KRT20
15	androgenic alopecia	10.2	AR KLK3
16	adenocarcinoma in situ	10.2	KRT20 PAX2
17	meibomian cyst	10.2	AR KRT20
18	withdrawal disorder	10.2	AR KLK3
19	paget disease, extramammary	10.2	AR KRT20
20	prostatitis	10.2
21	adenocarcinoma	10.2
22	prostatic hypertrophy	10.2	AR KLK3
23	infiltrative basal cell carcinoma	10.2	AR KRT20
24	nephrogenic adenoma	10.1	AMACR KLK3 PAX2
25	gynecomastia	10.1	AR KLK3
26	pancreatic mucinous cystadenoma	10.1	KRT20 MUC5B
27	female breast cancer	10.1	AR KLK3
28	male reproductive system disease	10.1	AR KLK3
29	sweat gland cancer	10.0	AR KRT20
30	prostate embryonal rhabdomyosarcoma	10.0	KIT KLK3
31	prostate rhabdomyosarcoma	10.0	KIT KLK3
32	cutaneous ganglioneuroma	9.9	KIT KRT20
33	intratubular embryonal carcinoma	9.9	KIT KRT20
34	cystitis cystica	9.9	AR KLK3 KRT20
35	dermoid cyst	9.8	KIT KRT20
36	breast adenoid cystic carcinoma	9.8	AR KIT
37	papillary hidradenoma	9.8	AR KIT
38	reproductive system disease	9.8	AR KLK3
39	large cell neuroendocrine carcinoma	9.7	KIT KRT20
40	oncocytoma	9.6	AMACR KIT
41	suppression of tumorigenicity 12	9.6	AMACR AR KLK3 TMPRSS2
42	male reproductive organ cancer	9.6	AMACR AR KLK3 TMPRSS2
43	clear cell adenocarcinoma	9.6	AMACR KLK3 KRT20 PAX2
44	kidney benign neoplasm	9.6	AMACR KIT PAX2
45	integumentary system cancer	9.6	KIT KRT20
46	rete testis adenocarcinoma	9.5	KIT KLK3 KRT20
47	cell type cancer	9.5	KIT KLK3 KRT20
48	ovarian brenner tumor	9.5	KIT KRT20 PAX2
49	merkel cell carcinoma	9.4	KIT KRT20
50	renal cell carcinoma, papillary, 1	9.2	AMACR KIT

Graphical network of the top 20 diseases related to Prostatic Acinar Adenocarcinoma:

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Symptoms & Phenotypes for Prostatic Acinar Adenocarcinoma

MGI Mouse Phenotypes related to Prostatic Acinar Adenocarcinoma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	embryo	MP:0005380	9.02	AR KIT PAX2 SOCS3 TMPRSS2

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Drugs & Therapeutics for Prostatic Acinar Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Prostatic Acinar Adenocarcinoma

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Genetic Tests for Prostatic Acinar Adenocarcinoma

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Anatomical Context for Prostatic Acinar Adenocarcinoma

MalaCards organs/tissues related to Prostatic Acinar Adenocarcinoma:

⁴¹

Prostate

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Publications for Prostatic Acinar Adenocarcinoma

Articles related to Prostatic Acinar Adenocarcinoma:

#	Title	Authors	Year
1	The benign mimickers of prostatic acinar adenocarcinoma. ( 27041929 )	Xu Y....Zhang J.	2016
2	The prognostic role of ERG immunopositivity in prostatic acinar adenocarcinoma: a study including 454 cases and review of the literature. ( 24406017 )	Xu B....Brimo F.	2013
3	Micropapillary carcinoma: new variant of prostatic acinar adenocarcinoma. ( 23106591 )	Mneimneh W.S....Nazeer T.	2012

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Genes for Prostatic Acinar Adenocarcinoma

Genes related to Prostatic Acinar Adenocarcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TMPRSS2	Transmembrane Serine Protease 2	Protein Coding	15.78	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	AMACR	Alpha-Methylacyl-CoA Racemase	Protein Coding	15.76	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	KLK3	Kallikrein Related Peptidase 3	Protein Coding	15.08	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	PAX2	Paired Box 2	Protein Coding	14.73	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	KRT20	Keratin 20	Protein Coding	14.38	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	MUC5B	Mucin 5B, Oligomeric Mucus/Gel-Forming	Protein Coding	14.35	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	SOCS3	Suppressor Of Cytokine Signaling 3	Protein Coding	14.28	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	KIT	KIT Proto-Oncogene Receptor Tyrosine Kinase	Protein Coding	13.35	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	AR	Androgen Receptor	Protein Coding	13.32	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)

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Variations for Prostatic Acinar Adenocarcinoma

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Expression for Prostatic Acinar Adenocarcinoma

Search GEO for disease gene expression data for Prostatic Acinar Adenocarcinoma.

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Pathways for Prostatic Acinar Adenocarcinoma

Pathways related to Prostatic Acinar Adenocarcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Endometrial cancer ³⁷ Show member pathways Acute myeloid leukemia ³⁷ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁶ Chronic myeloid leukemia ³⁷ Colorectal cancer ³⁷ Pancreatic cancer ³⁷ Prostate cancer ³⁷ Signal transduction PTEN pathway ²² Thyroid cancer ³⁷	12.2	AR KIT KLK3 TMPRSS2
2	FOXA1 transcription factor network ¹ Show member pathways FOXA transcription factor networks ¹	10.92	AR KLK3
3	Coregulation of Androgen receptor activity ¹	10.89	AR KLK3 TMPRSS2
4	Regulation of Androgen receptor activity ¹	10.5	AR KLK3 TMPRSS2

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GO Terms for Prostatic Acinar Adenocarcinoma

Biological processes related to Prostatic Acinar Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	9.32	KIT SOCS3
2	positive regulation of cell differentiation	GO:0045597	9.26	AR SOCS3
3	stem cell differentiation	GO:0048863	9.16	KIT PAX2
4	negative regulation of programmed cell death	GO:0043069	8.96	KIT PAX2
5	regulation of systemic arterial blood pressure	GO:0003073	8.62	AR KLK3

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