MCID: PRS006
MIFTS: 27

Prostatic Acinar Adenocarcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Prostatic Acinar Adenocarcinoma

MalaCards integrated aliases for Prostatic Acinar Adenocarcinoma:

Name: Prostatic Acinar Adenocarcinoma 12 15
Acinar Prostate Adenocarcinoma 71

Classifications:



External Ids:

Disease Ontology 12 DOID:3024
NCIt 49 C5596
UMLS 71 C1332139

Summaries for Prostatic Acinar Adenocarcinoma

MalaCards based summary : Prostatic Acinar Adenocarcinoma, also known as acinar prostate adenocarcinoma, is related to suppression of tumorigenicity 12 and prostate cancer. An important gene associated with Prostatic Acinar Adenocarcinoma is AR (Androgen Receptor), and among its related pathways/superpathways are Pathways in cancer and Endometrial cancer. Affiliated tissues include prostate, bone and testis, and related phenotype is neoplasm.

Related Diseases for Prostatic Acinar Adenocarcinoma

Diseases related to Prostatic Acinar Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 suppression of tumorigenicity 12 28.2 TMPRSS2 SLC45A3 NKX3-1 KLK3 AR AMACR
2 prostate cancer 27.7 TMPRSS2 SLC45A3 NKX3-1 KLK3 ERG AR
3 adenocarcinoma 10.4
4 prostate adenoid cystic carcinoma 10.2 KLK3 AR
5 prostate leiomyoma 10.2 KLK3 AR
6 submandibular gland cancer 10.2 KLK3 AR
7 male urethral cancer 10.2 KLK3 AMACR
8 prostate lymphoma 10.2 KLK3 AMACR
9 female urethral cancer 10.2 KLK3 AMACR
10 prostatic hyperplasia, benign 10.1 KLK3 AR
11 wolffian duct adenocarcinoma 10.1 PAX8 AR
12 bladder adenocarcinoma 10.1 KLK3 AMACR
13 nephrogenic adenoma of urinary bladder 10.1 PAX8 AMACR
14 withdrawal disorder 10.1 KLK3 AR
15 renal adenoma 10.1 PAX8 AMACR
16 androgenic alopecia 10.1 KLK3 AR
17 prostate small cell carcinoma 10.1 TMPRSS2 SLC45A3
18 bladder clear cell adenocarcinoma 10.1 PAX8 AMACR
19 adult mesoblastic nephroma 10.1 PAX8 AMACR
20 urethra cancer 10.1 PAX8 KLK3
21 bladder benign neoplasm 10.1 PAX8 AMACR
22 sex development disorder 10.1 KLK3 AR
23 kidney benign neoplasm 10.0 PAX8 AMACR
24 prostatic hypertrophy 10.0 KLK3 AR
25 epididymis adenocarcinoma 10.0 PAX8 KLK3
26 epididymis cancer 10.0 PAX8 KLK3
27 sexual disorder 10.0 KLK3 AR
28 gynecomastia 10.0 KLK3 AR
29 rete testis neoplasm 9.9 PAX8 NKX3-1
30 collecting duct carcinoma 9.9 PAX8 AMACR
31 rete testis adenocarcinoma 9.9 PAX8 NKX3-1
32 villous adenoma 9.9 SLC45A3 KLK3
33 prostate neuroendocrine neoplasm 9.9 TMPRSS2 KLK3 AR
34 female breast cancer 9.9 KLK3 AR
35 small cell carcinoma 9.9 TMPRSS2 KLK3 AR
36 prostate disease 9.8 KLK3 AR AMACR
37 male reproductive organ cancer 9.8 TMPRSS2 KLK3 AR
38 wolffian duct adenoma 9.8 PAX8 KLK3 AMACR
39 urethral diverticulum 9.8 PAX8 KLK3 AMACR
40 nephrogenic adenoma of the urethra 9.8 PAX8 KLK3 AMACR
41 male reproductive system disease 9.8 TMPRSS2 KLK3 AR
42 urethral benign neoplasm 9.8 PAX8 KLK3 AMACR
43 urethra clear cell adenocarcinoma 9.8 PAX8 KLK3 AMACR
44 clear cell adenocarcinoma 9.8 PAX8 KLK3 AMACR
45 adenosquamous prostate carcinoma 9.7 NKX3-1 KLK3 AMACR
46 impotence 9.7 KLK3 AR
47 prostatitis 9.6 NKX3-1 KLK3
48 nephrogenic adenoma 9.3 PAX8 NKX3-1 KLK3 AMACR

Graphical network of the top 20 diseases related to Prostatic Acinar Adenocarcinoma:



Diseases related to Prostatic Acinar Adenocarcinoma

Symptoms & Phenotypes for Prostatic Acinar Adenocarcinoma

MGI Mouse Phenotypes related to Prostatic Acinar Adenocarcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.92 AR ERG NKX3-1 TMPRSS2

Drugs & Therapeutics for Prostatic Acinar Adenocarcinoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Initial Experience in Brazilian Single Center With High Intensity Focalized Ultrasound (HIFU) Prostate Cancer Therapy: Morbidity, Oncological and Functional Outcomes. Active, not recruiting NCT03255135

Search NIH Clinical Center for Prostatic Acinar Adenocarcinoma

Genetic Tests for Prostatic Acinar Adenocarcinoma

Anatomical Context for Prostatic Acinar Adenocarcinoma

MalaCards organs/tissues related to Prostatic Acinar Adenocarcinoma:

40
Prostate, Bone, Testis, Bone Marrow, Kidney, Breast

Publications for Prostatic Acinar Adenocarcinoma

Articles related to Prostatic Acinar Adenocarcinoma:

(show all 33)
# Title Authors PMID Year
1
Pigs in a blanket: an unusual presentation of malignant ascites in prostatic adenocarcinoma. 61
31732542 2019
2
The Association of Invasive Cribriform Lesions With Adverse Prostatic Adenocarcinoma Outcomes: An Institutional Experience, Systematic Review, and Meta-analysis. 61
30702333 2019
3
34BetaE12 and Alfa-Methylacyl Coenzyme A Racemase (AMACR) Antibodies Better Than p63 Antibody Distinguish Normal and Neoplastic Glands in Prostatic Tissue With Thermal Artifacts. 61
29346181 2019
4
Rare Variant of Carcinoma Prostate Masquerading as Benign Prostatic Hyperplasia. 61
31249766 2019
5
Prognostic Significance of High Androgen Receptor Expression in Prostatic Acinar Adenocarcinoma 61
30912411 2019
6
ERG oncoprotein expression in prostatic acinar adenocarcinoma; clinicopathologic significance. 61
30658688 2019
7
Updates on Grading and Staging of Prostate Cancer. 61
30447840 2018
8
Skene's Glands Adenocarcinoma: A Series of 4 Cases. 61
29901570 2018
9
Prostatic Adenocarcinoma With Focal Pleomorphic Giant Cell Features: A Series of 30 Cases. 61
29944471 2018
10
Prostate Ductal Adenocarcinoma. 61
28362706 2018
11
Loss of PSMA Expression in Non-neuroendocrine Dedifferentiated Acinar Prostate Cancer. 61
29659395 2018
12
SOCS3 Immunohistochemical Expression Seems to Support the 2005 and 2014 International Society of Urological Pathology (ISUP) Modified Gleason Grading System. 61
28144985 2017
13
Acinar Adenocarcinoma of Prostate with Predominant Ttf-1 Positive Intraductal Component. 61
28044303 2017
14
The benign mimickers of prostatic acinar adenocarcinoma. 61
27041929 2016
15
Increased androgen receptor gene copy number is associated with TMPRSS2-ERG rearrangement in prostatic small cell carcinoma. 61
24777847 2015
16
Models of neuroendocrine prostate cancer. 61
25349195 2015
17
Bone marrow metastasis of prostatic adenocarcinoma with post-treatment foamy-like changes: A diagnostic pitfall. 61
25553175 2014
18
Pseudopapillary features in prostatic adenocarcinoma mimicking urothelial carcinoma: a diagnostic pitfall. 61
24503758 2014
19
The prognostic role of ERG immunopositivity in prostatic acinar adenocarcinoma: a study including 454 cases and review of the literature. 61
24406017 2014
20
Large gastrointestinal stromal tumor and advanced adenocarcinoma in the rectum coexistent with an incidental prostate carcinoma: A case report. 61
25052916 2014
21
Foamy gland carcinoma of the prostate in needle biopsy: incidence, Gleason grade, and comparative α-methylacyl-CoA racemase vs. ERG expression. 61
23797726 2013
22
Micropapillary carcinoma: new variant of prostatic acinar adenocarcinoma. 61
23106591 2012
23
[Results of karyometry of acinar adenocarcinoma of the prostate]. 61
23342659 2012
24
Foamy gland adenocarcinoma of the prostate: incidence, Gleason grade, and early clinical outcome. 61
22221706 2012
25
Selected common diagnostic problems in urologic pathology: perspectives from a large consult service in genitourinary pathology. 61
22458899 2012
26
A rare case of metastatic ductal type prostate adenocarcinoma presenting with syndrome of inappropriate secretion of antidiuretic hormone: a case report and review. 61
22842384 2012
27
Cystic prostatic ductal adenocarcinoma: an unusual presentation and cytological diagnosis. 61
22371914 2012
28
An 82-year-old Caucasian man with a ductal prostate adenocarcinoma with unusual cystoscopic appearance: a case report. 61
21223563 2011
29
The distribution of PAX-2 immunoreactivity in the prostate gland, seminal vesicle, and ejaculatory duct: comparison with prostatic adenocarcinoma and discussion of prostatic zonal embryogenesis. 61
20413145 2010
30
TMPRSS2-ERG gene fusions are infrequent in prostatic ductal adenocarcinomas. 61
19151660 2009
31
[Prostatic duct adenocarcinoma with pagetoid spread on the glans penis: a case report]. 61
17176876 2006
32
Carcinosarcoma of the prostate. Report of 21 cases. 61
8625205 1995
33
Papillary adenocarcinoma of prostate. 61
184573 1976

Variations for Prostatic Acinar Adenocarcinoma

Expression for Prostatic Acinar Adenocarcinoma

Search GEO for disease gene expression data for Prostatic Acinar Adenocarcinoma.

Pathways for Prostatic Acinar Adenocarcinoma

GO Terms for Prostatic Acinar Adenocarcinoma

Cellular components related to Prostatic Acinar Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromatin GO:0000790 8.92 PAX8 NKX3-1 ERG AR

Biological processes related to Prostatic Acinar Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of epithelial cell proliferation GO:0050680 9.4 NKX3-1 AR
2 androgen receptor signaling pathway GO:0030521 9.37 NKX3-1 AR
3 metanephros development GO:0001656 9.32 PAX8 NKX3-1
4 urogenital system development GO:0001655 9.26 PAX8 NKX3-1
5 prostate gland development GO:0030850 9.16 NKX3-1 AR
6 regulation of systemic arterial blood pressure GO:0003073 8.96 KLK3 AR
7 cellular response to steroid hormone stimulus GO:0071383 8.62 NKX3-1 AR

Molecular functions related to Prostatic Acinar Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.67 PAX8 NKX3-1 ERG AR
2 DNA-binding transcription factor activity GO:0003700 9.62 PAX8 NKX3-1 ERG AR
3 transcription regulatory region DNA binding GO:0044212 9.33 PAX8 NKX3-1 AR
4 nuclear receptor activity GO:0004879 9.26 NKX3-1 AR
5 sequence-specific DNA binding GO:0043565 9.26 PAX8 NKX3-1 ERG AR
6 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 8.92 PAX8 NKX3-1 ERG AR

Sources for Prostatic Acinar Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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