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MCID: PRS006
MIFTS: 34

Prostatic Acinar Adenocarcinoma

Categories: Cancer diseases, Reproductive diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Prostatic Acinar Adenocarcinoma

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MalaCards integrated aliases for Prostatic Acinar Adenocarcinoma:

Name: Prostatic Acinar Adenocarcinoma 12 15
Acinar Prostate Adenocarcinoma 74

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3024
NCIt 51 C5596
UMLS 74 C1332139
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Summaries for Prostatic Acinar Adenocarcinoma

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MalaCards based summary : Prostatic Acinar Adenocarcinoma, also known as acinar prostate adenocarcinoma, is related to prostate sarcoma and bladder diverticulum. An important gene associated with Prostatic Acinar Adenocarcinoma is AMACR (Alpha-Methylacyl-CoA Racemase), and among its related pathways/superpathways are Endometrial cancer and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include kidney, testis and appendix, and related phenotypes are cellular and embryo

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Related Diseases for Prostatic Acinar Adenocarcinoma

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Diseases related to Prostatic Acinar Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 158)
# Related Disease Score Top Affiliating Genes
1 prostate sarcoma 10.4 KLK3 NKX3-1
2 bladder diverticulum 10.4 AMACR PAX2
3 adenocarcinoma 10.4
4 urethra adenocarcinoma 10.4 AMACR KLK3
5 urethra clear cell adenocarcinoma 10.4 AMACR KLK3
6 rete testis adenoma 10.4 PAX2 PAX8
7 childhood endodermal sinus tumor 10.4 PAX2 PAX8
8 urethral benign neoplasm 10.3 AMACR KLK3
9 clear cell papillary renal cell carcinoma 10.3 AMACR KRT7
10 papillary adenoma 10.3 AMACR KRT7
11 lymphoepithelioma-like carcinoma 10.3 KRT20 KRT7
12 vaginal benign neoplasm 10.3 CDX2 KRT20
13 vaginal adenoma 10.3 CDX2 KRT20
14 vaginal tubulovillous adenoma 10.3 CDX2 KRT20
15 bile duct mucoepidermoid carcinoma 10.2 KRT7 MUC5B
16 cystic basal cell carcinoma 10.2 KRT20 KRT7
17 transverse colon cancer 10.2 KRT20 KRT7
18 renal pelvis adenocarcinoma 10.2 KRT7 PAX8
19 malignant syringoma 10.2 KRT20 KRT7
20 sensory organ benign neoplasm 10.2 KRT7 PAX8
21 papillary transitional carcinoma 10.2 KRT20 KRT7
22 eyelid carcinoma 10.2 KRT20 KRT7
23 krukenberg carcinoma 10.2 KRT20 KRT7
24 large intestine adenocarcinoma 10.2 KRT20 KRT7
25 linitis plastica 10.2 KRT20 KRT7
26 lung acinar adenocarcinoma 10.2 KRT20 KRT7
27 small cell carcinoma of the bladder 10.2 KRT20 KRT7
28 adenoid squamous cell carcinoma 10.2 KRT20 KRT7
29 endocervical carcinoma 10.2 KRT7 PAX8
30 ovary neuroendocrine neoplasm 10.2 CDX2 KRT7
31 male reproductive organ cancer 10.2 AMACR KLK3 NKX3-1 TMPRSS2
32 vulval paget's disease 10.2 KRT20 KRT7
33 male reproductive system disease 10.2 AMACR KLK3 NKX3-1 TMPRSS2
34 reproductive system disease 10.2 AMACR KLK3 NKX3-1 TMPRSS2
35 bile duct cystadenocarcinoma 10.2 KRT20 KRT7
36 prostate disease 10.2 AMACR KLK3 NKX3-1 TMPRSS2
37 bile duct adenoma 10.2 KRT20 KRT7
38 seminal vesicle tumor 10.2 KLK3 KRT7
39 suppression of tumorigenicity 12 10.2 AMACR KLK3 NKX3-1 TMPRSS2
40 mucinous adenofibroma 10.2 CDX2 KRT7
41 anus adenocarcinoma 10.2 CDX2 KRT7
42 meibomian cyst 10.2 KRT20 KRT7
43 bladder lymphoma 10.2 KRT20 KRT7
44 papillary serous adenocarcinoma 10.1 KRT20 KRT7
45 male reproductive organ benign neoplasm 10.1 KLK3 WT1
46 duodenum adenocarcinoma 10.1 CDX2 KRT7
47 villous adenoma 10.1 CDX2 KLK3 KRT20
48 collecting duct carcinoma 10.1 AMACR KRT7 PAX8
49 nasal cavity cancer 10.1 CDX2 KRT7
50 prostate embryonal rhabdomyosarcoma 10.1 KIT KLK3

Graphical network of the top 20 diseases related to Prostatic Acinar Adenocarcinoma:



Diseases related to Prostatic Acinar Adenocarcinoma
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Symptoms & Phenotypes for Prostatic Acinar Adenocarcinoma

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MGI Mouse Phenotypes related to Prostatic Acinar Adenocarcinoma:

47 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.22 CDX2 ERG KIT KRT7 MUC5B NKX3-1
2 embryo MP:0005380 10.16 CDX2 ERG KIT NKX3-1 PAX2 PAX8
3 homeostasis/metabolism MP:0005376 10.11 AMACR CDX2 ERG KIT KRT7 MUC5B
4 cardiovascular system MP:0005385 10.1 CDX2 ERG KIT PAX2 PAX8 SATB2
5 growth/size/body region MP:0005378 10.1 AMACR CDX2 ERG KIT MUC5B PAX8
6 mortality/aging MP:0010768 10.1 AMACR CDX2 ERG KIT MUC5B NKX3-1
7 endocrine/exocrine gland MP:0005379 10.09 CDX2 ERG KIT NKX3-1 PAX2 PAX8
8 neoplasm MP:0002006 9.73 CDX2 ERG KIT NKX3-1 TMPRSS2 WT1
9 normal MP:0002873 9.7 CDX2 ERG KIT PAX8 SOCS3 TMPRSS2
10 reproductive system MP:0005389 9.56 CDX2 ERG KIT NKX3-1 PAX2 PAX8
11 respiratory system MP:0005388 9.17 ERG KIT MUC5B SATB2 SOCS3 TMPRSS2
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Drugs & Therapeutics for Prostatic Acinar Adenocarcinoma

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Search Clinical Trials , NIH Clinical Center for Prostatic Acinar Adenocarcinoma

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Genetic Tests for Prostatic Acinar Adenocarcinoma

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Anatomical Context for Prostatic Acinar Adenocarcinoma

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MalaCards organs/tissues related to Prostatic Acinar Adenocarcinoma:

42
Kidney, Testis, Appendix, Ovary, Thymus, Colon, Small Intestine
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Publications for Prostatic Acinar Adenocarcinoma

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Articles related to Prostatic Acinar Adenocarcinoma:

# Title Authors Year
1
Prognostic Significance of High Androgen Receptor Expression in Prostatic Acinar Adenocarcinoma ( 30912411 )
2019
2
ERG oncoprotein expression in prostatic acinar adenocarcinoma; clinicopathologic significance. ( 30658688 )
2019
3
The benign mimickers of prostatic acinar adenocarcinoma. ( 27041929 )
2016
4
The prognostic role of ERG immunopositivity in prostatic acinar adenocarcinoma: a study including 454 cases and review of the literature. ( 24406017 )
2014
5
Micropapillary carcinoma: new variant of prostatic acinar adenocarcinoma. ( 23106591 )
2012
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Variations for Prostatic Acinar Adenocarcinoma

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Expression for Prostatic Acinar Adenocarcinoma

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Search GEO for disease gene expression data for Prostatic Acinar Adenocarcinoma.
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Pathways for Prostatic Acinar Adenocarcinoma

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Pathways related to Prostatic Acinar Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Endometrial cancer 38
Show member pathways
 11.85 ERG KIT KLK3 NKX3-1 PAX8 TMPRSS2
2
Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers 66
11.62 CDX2 PAX2 WT1
3
Transcriptional misregulation in cancer 38
11.53 ERG PAX8 TMPRSS2 WT1
4
Coregulation of Androgen receptor activity 1
11.09 KLK3 NKX3-1 TMPRSS2
5
ID signaling pathway 1
10.46 PAX2 PAX8
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GO Terms for Prostatic Acinar Adenocarcinoma

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Biological processes related to Prostatic Acinar Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 male gonad development GO:0008584 9.79 KIT NKX3-1 WT1
2 branching involved in ureteric bud morphogenesis GO:0001658 9.65 PAX2 PAX8 WT1
3 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.63 PAX2 PAX8
4 negative regulation of programmed cell death GO:0043069 9.63 KIT PAX2
5 mesonephros development GO:0001823 9.61 PAX2 PAX8
6 mesenchymal to epithelial transition GO:0060231 9.59 PAX2 WT1
7 cellular response to gonadotropin stimulus GO:0071371 9.58 PAX8 WT1
8 metanephric mesenchyme development GO:0072075 9.58 PAX2 WT1
9 mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003337 9.57 PAX2 PAX8
10 pronephros development GO:0048793 9.56 PAX2 PAX8
11 regulation of metanephric nephron tubule epithelial cell differentiation GO:0072307 9.55 PAX2 PAX8
12 metanephric S-shaped body morphogenesis GO:0072284 9.54 PAX8 WT1
13 metanephric distal convoluted tubule development GO:0072221 9.52 PAX2 PAX8
14 metanephric nephron tubule formation GO:0072289 9.51 PAX2 PAX8
15 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0072108 9.49 PAX2 PAX8
16 negative regulation of mesenchymal cell apoptotic process involved in metanephros development GO:1900212 9.46 PAX2 PAX8
17 transcription by RNA polymerase II GO:0006366 9.43 CDX2 PAX2
18 negative regulation of apoptotic process involved in metanephric collecting duct development GO:1900215 9.4 PAX2 PAX8
19 negative regulation of apoptotic process involved in metanephric nephron tubule development GO:1900218 9.37 PAX2 PAX8
20 negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis GO:0072305 9.32 PAX2 PAX8
21 positive regulation of metanephric DCT cell differentiation GO:2000594 9.26 PAX2 PAX8
22 pronephric field specification GO:0039003 9.16 PAX2 PAX8
23 urogenital system development GO:0001655 9.13 NKX3-1 PAX2 PAX8
24 metanephric epithelium development GO:0072207 8.8 PAX2 PAX8 WT1
25 positive regulation of transcription by RNA polymerase II GO:0045944 10.1 ERG NKX3-1 PAX2 PAX8 SATB2 WT1
26 multicellular organism development GO:0007275 10.09 CDX2 ERG NKX3-1 PAX2 PAX8 SATB2
27 positive regulation of transcription, DNA-templated GO:0045893 10 CDX2 NKX3-1 PAX2 PAX8 WT1

Molecular functions related to Prostatic Acinar Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.86 CDX2 ERG NKX3-1 PAX2 PAX8 PIN4
2 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.7 CDX2 ERG NKX3-1 PAX2 PAX8 SATB2
3 transcription regulatory region DNA binding GO:0044212 9.26 NKX3-1 PAX2 PAX8 WT1
4 sequence-specific DNA binding GO:0043565 9.1 CDX2 ERG NKX3-1 PAX8 SATB2 WT1
5 protein binding GO:0005515 10.17 ERG KIT KLK3 KRT20 KRT7 MUC5B
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Sources for Prostatic Acinar Adenocarcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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