MCID: PRS021
MIFTS: 38

Prostatic Adenoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Prostatic Adenoma

MalaCards integrated aliases for Prostatic Adenoma:

Name: Prostatic Adenoma 12 55 15 73
Prostatic Hyperplasia 44 73
Benign Prostatic Hyperplasia 73
Benign Adenoma of Prostate 12
Adenoma of Prostate 12
Adenoma - Prostate 12
Prostate Adenoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2883
MeSH 44 D011470
NCIt 50 C4795

Summaries for Prostatic Adenoma

MalaCards based summary : Prostatic Adenoma, also known as prostatic hyperplasia, is related to prostatic hyperplasia, benign and prostatitis, and has symptoms including prostatism An important gene associated with Prostatic Adenoma is UCA1 (Urothelial Cancer Associated 1
Besides normal individuals,patients with various pathologic conditions of the urinary tract were selected to test the differential diagnostic performance of UCA1 assay,including upper urinary tract restriction or reflux,neurogenic bladder,cystitis glandularis,lithiasis,benign prostatic hyperplasia,and renal cell carcinoma. UCA1 assay shows very high negative readings in all kinds of urinary tract diseases without TCC.
Dysfunction Pattern: Regulation [down-regulated]), and among its related pathways/superpathways are Androgen receptor signaling pathway and Coregulation of Androgen receptor activity. The drugs UroXatral and Etidronic acid have been mentioned in the context of this disorder. Affiliated tissues include prostate and bone.

Related Diseases for Prostatic Adenoma

Diseases related to Prostatic Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)
# Related Disease Score Top Affiliating Genes
1 prostatic hyperplasia, benign 28.9 AR KLK3
2 prostatitis 10.5
3 adenoma 10.5
4 sexual disorder 10.0 KLK3 SHBG
5 penis agenesis 9.9 AR SRD5A1
6 urethritis 9.9
7 osteogenic sarcoma 9.9 CDKN2B-AS1 UCA1
8 breast disease 9.8 KLK3 SHBG
9 47, xxy 9.8 AR SHBG
10 postmenopausal atrophic vaginitis 9.8 AR SHBG
11 type i 9.8
12 complete androgen insensitivity syndrome 9.7 AR SHBG
13 sex differentiation disease 9.7 AR SHBG
14 androgen insensitivity syndrome 9.7 AR SHBG
15 gallbladder cancer 9.7 CDKN2B-AS1 UCA1
16 nodular prostate 9.7 AR KLK3
17 prostatic acinar adenocarcinoma 9.6 AR KLK3
18 aging 9.6
19 urethral benign neoplasm 9.6
20 gonadal disease 9.6 AR SHBG
21 withdrawal disorder 9.6 AR KLK3
22 impotence 9.6 KLK3 SHBG SRD5A1
23 prostatic hypertrophy 9.6 AR KLK3
24 cystitis cystica 9.6 AR KLK3
25 cryptorchidism, unilateral or bilateral 9.6 AR SHBG
26 female breast cancer 9.5 AR KLK3
27 male reproductive system disease 9.5 AR KLK3
28 hypospadias 9.5 AR SRD5A1
29 alopecia 9.5 AR SHBG
30 suppression of tumorigenicity 12 9.5 AR KLK3
31 adamantinoma of long bones 9.5 CDKN2B-AS1 KLK3 UCA1
32 acute myocardial infarction 9.4 CDKN2B-AS1 UCA1
33 androgen insensitivity, partial 9.4 AR SHBG SRD5A1
34 alopecia, androgenetic, 1 9.4 AR SHBG SRD5A1
35 androgenic alopecia 9.1 AR KLK3 SHBG
36 gynecomastia 9.1 AR KLK3 SHBG
37 male reproductive organ cancer 9.1 AR KLK3 SHBG
38 reproductive system disease 9.1 AR KLK3 SHBG
39 endometrial cancer 8.9 AR SHBG UCA1
40 prostate cancer 7.5 AR CDKN2B-AS1 KLK3 SHBG SRD5A1 UCA1

Graphical network of the top 20 diseases related to Prostatic Adenoma:



Diseases related to Prostatic Adenoma

Symptoms & Phenotypes for Prostatic Adenoma

UMLS symptoms related to Prostatic Adenoma:


prostatism

Drugs & Therapeutics for Prostatic Adenoma

FDA approved drugs:

# Drug Name Active Ingredient(s) 18 Company Approval Date
1
UroXatral 18 ALFUZOSIN HYDROCHLORIDE Sanofi-aventis June 2003

Drugs for Prostatic Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etidronic acid Approved Phase 3 7414-83-7, 2809-21-4 3305
2
Leuprolide Approved, Investigational Phase 3 53714-56-0 3911 657181
3 Androgens Phase 3
4 Bone Density Conservation Agents Phase 3
5 calcium channel blockers Phase 3
6 Calcium, Dietary Phase 3
7 Risedronate Sodium Phase 3 115436-72-1
8 Anesthetics Not Applicable

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Holmium Laser Enucleation of Prostate(HOLEP) vs Greenlight(XPS) Laser Photoselective Vapo-Enucleation of Prostate(PVEP) Completed NCT01494337 Phase 4
2 Evaluation of the Effects of Different Prostate Surgeries on Urinary and Sexual Function Completed NCT01810068 Phase 4
3 GreenLight Laser Photoselective Vaporization of the Prostate vs Plasma Kinetic Vaporization of the Prostate; RCT Active, not recruiting NCT02283684 Phase 4
4 Efficacy Study of Risedronate to Prevent Cancer Treatment-Induced Bone Loss in Prostate Cancer Completed NCT00426777 Phase 3 risedronate;risedronate;Control
5 The Safety and Efficacy of Ozarelix to Treat Men With Lower Urinary Tract Symptoms Due to Enlargement of the Prostate Completed NCT00427219 Phase 2, Phase 3 Ozarelix/Placebo;Placebo
6 Sexual Steroids: Relationship Between Serum and Prostatic Tissue Level Completed NCT02778243 Not Applicable
7 ThuLEP vs. HoLEP vs. Monopolar Enucleation in Management of BPH Completed NCT03230721 Not Applicable
8 Bone Health Observational Study Completed NCT00632905
9 Establishment and Clinical Assessment of a Prostate Cancer (PCa) Risk Model Based on the Updated Circulating Tumor Cell (CTC) Detection Technique Recruiting NCT02940977
10 Evaluation of the Satisfaction of the Patients Operated for a Mild Hyperplasie of the Prostate by Laser in Ambulatory Surgery Recruiting NCT03474419
11 High Power Thulium Vaporization vs Transurethral Resection of the Prostate for Treatment of BPH Recruiting NCT03264482 Not Applicable
12 Feasibility Study of Photovaporisation of Prostate With a Limitated Length of Catheterization of 3 Hours Recruiting NCT02401581 Not Applicable
13 MRI Guided Transurethral HIFU for Various Prostate Diseases Recruiting NCT03350529 Not Applicable
14 Rezum FIM Optimization Active, not recruiting NCT02940392 Not Applicable
15 Rezum I Pilot Study for BPH Active, not recruiting NCT02943070 Not Applicable

Search NIH Clinical Center for Prostatic Adenoma

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: prostatic hyperplasia

Genetic Tests for Prostatic Adenoma

Anatomical Context for Prostatic Adenoma

MalaCards organs/tissues related to Prostatic Adenoma:

41
Prostate, Bone

Publications for Prostatic Adenoma

Articles related to Prostatic Adenoma:

(show top 50) (show all 56)
# Title Authors Year
1
mTUEPA: Trans-Urethral Monopolar Enucleation of Prostatic Adenoma. Preliminary Report. ( 28087281 )
2017
2
Efficacy and safety of holmium laser enucleation of the prostate for extremely large prostatic adenoma in patients with benign prostatic hyperplasia. ( 25763126 )
2015
3
Diagnosis of prostate adenoma and the relationship between the site of prostate adenoma and bladder outlet obstruction. ( 24068054 )
2013
4
Effects of I8-Da1a a peptidic I+(1) (A) -adrenoceptor antagonist in human isolated prostatic adenoma and anaesthetized rats. ( 23005263 )
2013
5
Management of large prostatic adenoma: Lasers versus bipolar transurethral resection of prostate. ( 24082445 )
2013
6
Re: Holmium laser enucleation versus photoselective vaporization for prostatic adenoma greater than 60 ml: preliminary results of a prospective, randomized clinical trial: H. Elmansy, A. Baazeem, A. Kotb, H. Badawy, E. Riad, A. Emran and M. Elhilali J Urol, 2012;188:216-221. ( 22986042 )
2013
7
The surgical treatment of a large prostatic adenoma: the laparoscopic approach--a systematic review. ( 22417323 )
2012
8
Holmium laser enucleation versus photoselective vaporization for prostatic adenoma greater than 60 ml: preliminary results of a prospective, randomized clinical trial. ( 22591968 )
2012
9
Holmium Laser Enucleation Versus Photoselective Vaporization for Prostatic Adenoma Greater than 60 ML: Preliminary Results of a Prospective, Randomized Clinical Trial. ( 22986036 )
2012
10
Assessment of neodymium:yttrium-aluminum-garnet (Nd:YAG) laser fiber wear and tear grade during visual laser ablation of prostatic adenoma. ( 19878030 )
2009
11
[Efficacy and safety of combined treatment of prostatic adenoma with 5-alpha reductase and alpha-adrenoblockers]. ( 20169718 )
2009
12
[Basic fibroblast growth factor as a prognostic factor of medication efficacy by meanes of prostatic adenoma]. ( 19248600 )
2008
13
[Dutasteride--an inhibitor of 5alpha-reductase of type I and II--in the treatment of patients with prostatic adenoma. What is the latest news?]. ( 18652016 )
2007
14
[Treatment of prostatic adenoma patients with inhibitor of 5-alpha-reductase of type I and II avodart (dutasteride)]. ( 17315721 )
2006
15
Predictives regarding outcome after transurethral resection for prostatic adenoma associated with detrusor underactivity. ( 16461081 )
2006
16
[Spontaneously acquired haemophilia: report of a patient with prostatic adenoma]. ( 16829479 )
2006
17
Holmium laser enucleation for prostatic adenoma: analysis of learning curve over the course of 70 consecutive cases. ( 14532790 )
2003
18
Histopathological changes in human prostatic adenoma following neodymium:YAG laser ablation therapy. ( 7523711 )
1994
19
Migrating foreign body within a prostatic adenoma. ( 8435742 )
1993
20
Histological study of Nd:YAG laser energy on prostatic adenoma as demonstrated in the intact prostate gland. ( 7688263 )
1993
21
[Effect of rectal examination in patients with prostatic adenoma on concentration of prostatic specific antigen (PSA) in plasma]. ( 7526558 )
1993
22
Evaluation of uroflowmetry in different groups of patients after transurethral resection of prostatic adenoma. ( 1718921 )
1991
23
Prazosin concentration monitoring in the treatment of prostatic adenoma. ( 1713902 )
1991
24
Zn, Ca and Na levels in the prostatic secretion of patients with prostatic adenoma. ( 1718918 )
1991
25
[5-alpha reductase inhibitor in prostatic adenoma?]. ( 1705307 )
1990
26
Gardnerella vaginalis bacteremia in a man with prostatic adenoma. ( 1688908 )
1990
27
Pharmacokinetics of ciprofloxacin in young (healthy volunteers) and elderly patients, and concentrations in prostatic fluid, seminal fluid, and prostatic adenoma tissue following intravenous administration. ( 2589386 )
1989
28
The effects of the alpha 1-adrenergic antagonists terazosin and phentolamine on prostatic adenoma and urethra in vitro. ( 2571162 )
1989
29
Case profile: prostatic adenoma masquerading as primary urethral neoplasm. ( 2459832 )
1988
30
Penetration of fleroxacin into prostatic secretion and prostatic adenoma tissue. ( 2468456 )
1988
31
In-vitro activity of fleroxacin against isolates causing complicated urinary tract infections and concentrations in seminal and prostatic fluid and in prostatic adenoma tissue. ( 2462556 )
1988
32
Ectopic prostatic adenoma in retrovesical space. ( 2437337 )
1987
33
CT features of perirectal fascia thickening after transurethral resection of prostatic adenoma. ( 2433317 )
1987
34
Aspects of transurethral resection of prostate for obstructing prostatic adenoma. ( 6164099 )
1980
35
Prostatic adenoma of ductal origin. ( 7395021 )
1980
36
Preliminary study of the action of the Yag laser on canine prostatic adenoma and experimental urethral stenosis. ( 7371667 )
1980
37
Weight estimation of benign prostatic adenoma with urethral pressure profile. ( 466005 )
1979
38
[Value of cryogenic surgery in the therapeutic plan for prostatic adenoma]. ( 69371 )
1977
39
Diagnostic and prognostic value of the cystograms of patients with prostatic adenoma: distance between symphysis pubis and urinary bladder. ( 73527 )
1977
40
Prostatic adenoma and carcinoma in cell culture and heterotransplantation. ( 66691 )
1976
41
Estimation of the size of prostatic adenoma by ultrasonography. A preliminary report. ( 64363 )
1976
42
Human prostatic adenoma and carcinoma. Transplantation of cultured cells and primary tissue fragments in "nude" mice. ( 57942 )
1976
43
Transurethral electroresection of prostatic adenoma. Early results. ( 58441 )
1976
44
Transurethral resection of prostatic adenoma in Basel. A comment to the paper by K. O. Obrant. ( 52165 )
1975
45
Mode of action of progesterone, gestonorone capronate (Depostat) and cyproterone acetate (Androcur) on the metabolism of testosterone in human prostatic adenoma: in vitro and in vivo investigations. ( 1177428 )
1975
46
Human prostatic adenoma and carcinoma in cell culture: the effects of androgen-free culture medium. ( 4140847 )
1974
47
Heterotransplantation of human prostatic adenoma cells, MA160, into nonimmunosuppressed hamsters. ( 4673144 )
1972
48
First experience with endoscopic cryosurgery of prostatic adenoma and carcinoma. ( 4117492 )
1971
49
Evaluation of Depostat in prostatic adenoma on the ground of clinical and sphincterotonometric studies. ( 4117491 )
1971
50
A case report of a heterotopic prostatic adenoma of the bladr. ( 4186837 )
1969

Variations for Prostatic Adenoma

Expression for Prostatic Adenoma

Search GEO for disease gene expression data for Prostatic Adenoma.

Pathways for Prostatic Adenoma

GO Terms for Prostatic Adenoma

Biological processes related to Prostatic Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 male gonad development GO:0008584 9.26 AR SRD5A1
2 sex differentiation GO:0007548 9.16 AR SRD5A1
3 regulation of systemic arterial blood pressure GO:0003073 8.96 AR KLK3
4 cellular response to testosterone stimulus GO:0071394 8.62 AR SRD5A1

Molecular functions related to Prostatic Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid binding GO:0005496 8.96 AR SHBG
2 androgen binding GO:0005497 8.62 AR SHBG

Sources for Prostatic Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....