MCID: PRS115
MIFTS: 45

Prosthetic Joint Infection

Categories: Rare diseases

Aliases & Classifications for Prosthetic Joint Infection

MalaCards integrated aliases for Prosthetic Joint Infection:

Name: Prosthetic Joint Infection 53 73
Joint Replacement Infection 53
Artificial Joint Infection 53
Knee Replacement Infection 53
Pji 53

Classifications:



External Ids:

UMLS 73 C0410808

Summaries for Prosthetic Joint Infection

NIH Rare Diseases : 53 A prosthetic joint infection (PJI) is a rare complication of joint replacement surgery, also known as arthroplasty.  Arthroplasty is done to help relieve pain and restore function in a severely diseased joint, such as a knee, hip or shoulder.  Approximately 0.5 to 1 percent of people with replacement joints develop a PJI.  Infections can occur early in the course of recovery from joint replacement surgery (within the first two months) or much later.  Signs and symptoms of PJI include fever, chills, drainage from the surgical site, and increasing redness, tenderness, swelling and pain of the affected joint.  Prosthetic joint infections are often hard to treat because of the development of a structure called a biofilm within the joint. A biofilm develops when bacteria adhere to the solid surface of the artificial joint. The biofilm can act as a kind of shield to some of the bacteria, making it difficult for the bacteria to be found and destroyed by the body's defenses or by antibiotic medications. An infected joint replacement usually requires surgery to remove the artificial parts and potent antibiotics to kill the bacteria. 

MalaCards based summary : Prosthetic Joint Infection, also known as joint replacement infection, is related to coccidioidomycosis and septic arthritis. An important gene associated with Prosthetic Joint Infection is IL1B (Interleukin 1 Beta), and among its related pathways/superpathways are Innate Immune System and Toll-like Receptor Signaling Pathway. The drugs Cloxacillin and Rifampicin have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and colon, and related phenotypes are hematopoietic system and immune system

Related Diseases for Prosthetic Joint Infection

Diseases related to Prosthetic Joint Infection via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
# Related Disease Score Top Affiliating Genes
1 coccidioidomycosis 29.5 MBL2 TLR4
2 septic arthritis 29.3 TLR2 TLR4
3 q fever 28.8 IL1B TLR2 TLR4
4 rheumatoid arthritis 28.2 IL1B TLR2 TLR4 TNFRSF11B
5 pneumonia 27.9 IL1B MBL2 TLR2 TLR4
6 juvenile polyposis syndrome 11.2
7 vulvar vestibulitis syndrome 10.3 IL1B MBL2
8 meningococcemia 10.3 IL1B MBL2
9 root resorption 10.3 IL1B TNFRSF11B
10 haemophilus influenzae 10.2 IL1B TLR2
11 arthritis 10.2
12 bone inflammation disease 10.1 IL1B TNFRSF11B
13 leptospirosis 10.1 IL1B TLR2
14 tularemia 10.1 MBL2 TLR2
15 lyme disease 10.1 IL1B TLR2
16 rheumatic fever 10.1 MBL2 TLR2
17 bacterial meningitis 10.1 IL1B TLR2
18 aortic aneurysm, familial abdominal, 1 10.1 IL1B TNFRSF11B
19 rheumatic disease 10.0 IL1B TNFRSF11B
20 synovitis 10.0 IL1B TNFRSF11B
21 endocarditis 10.0
22 osteomyelitis 10.0
23 peritonitis 10.0 IL1B TLR2
24 campylobacteriosis 10.0 IL1B TLR4
25 endometrial disease 10.0 IL1B TLR4
26 cysticercosis 9.9 IL1B TLR4
27 perinatal necrotizing enterocolitis 9.9 IL1B TLR4
28 bacteriuria 9.9
29 eosinophilic pneumonia 9.9
30 mycobacterium fortuitum 9.9
31 bronchiectasis 9.9 MBL2 TLR2
32 idiopathic neutropenia 9.9 IL1B TLR4
33 uterine anomalies 9.9 IL1B TLR4
34 pyelonephritis 9.9 IL1B TLR4
35 typhoid fever 9.9 IL1B TLR4
36 trypanosomiasis 9.9 IL1B TLR2
37 salmonellosis 9.9 IL1B TLR4
38 aggressive periodontitis 9.9 IL1B TLR4
39 chorioamnionitis 9.9 IL1B TLR4
40 lymphadenitis 9.8 IL1B TLR4
41 autoinflammation, lipodystrophy, and dermatosis syndrome 9.8 IL1B TLR4
42 toxoplasmosis 9.8 IL1B TLR4
43 helicobacter pylori infection 9.8 IL1B TLR4
44 trench fever 9.8 TLR2 TLR4
45 acute cervicitis 9.8 TLR2 TLR4
46 intestinal disease 9.8 IL1B TLR4
47 amyloidosis 9.8
48 candida glabrata 9.8
49 mycobacterium abscessus 9.8
50 myeloma, multiple 9.8

Graphical network of the top 20 diseases related to Prosthetic Joint Infection:



Diseases related to Prosthetic Joint Infection

Symptoms & Phenotypes for Prosthetic Joint Infection

MGI Mouse Phenotypes related to Prosthetic Joint Infection:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.35 MBL2 TLR2 TLR4 TNFRSF11B IL1B
2 immune system MP:0005387 9.02 MBL2 TLR2 TLR4 TNFRSF11B IL1B

Drugs & Therapeutics for Prosthetic Joint Infection

Drugs for Prosthetic Joint Infection (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 64)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cloxacillin Approved, Investigational, Vet_approved Phase 4 61-72-3 6098
2
Rifampicin Approved Phase 4,Phase 2,Not Applicable 13292-46-1 5458213 5381226
3
Daptomycin Approved, Investigational Phase 4,Phase 2 103060-53-3 16129629
4
Vancomycin Approved Phase 4,Phase 2,Not Applicable 1404-90-6 441141 14969
5
Cefazolin Approved Phase 4,Phase 2,Not Applicable 25953-19-9 656510 33255
6
Iodine Approved, Investigational Phase 4,Not Applicable 7553-56-2 807
7
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
8
Teicoplanin Approved, Investigational Phase 4,Not Applicable 61036-62-2
9
Fosfomycin Approved Phase 4 23155-02-4 446987
10
Dalbavancin Approved, Investigational Phase 4 91097-81-3, 171500-79-1 122186
11
Nafcillin Approved, Investigational Phase 4,Phase 2 985-16-0, 147-52-4 8982
12 methicillin Phase 4
13 Cytochrome P-450 CYP3A Inducers Phase 4,Phase 2
14 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 2
15 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable
16 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Not Applicable
17 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
18 Antitubercular Agents Phase 4,Phase 3,Phase 2,Not Applicable
19 Chlorhexidine gluconate Phase 4
20 cadexomer iodine Phase 4,Not Applicable
21 Dermatologic Agents Phase 4
22 Disinfectants Phase 4
23 Pharmaceutical Solutions Phase 4
24 Anti-Infective Agents, Local Phase 4
25
Fusidic Acid Approved, Investigational Phase 2, Phase 3,Not Applicable 6990-06-3 3000226
26 Gentamicins Phase 3
27 Vaccines Phase 3
28
Ceftriaxone Approved Phase 2 73384-59-5 5479530 5361919
29
Sulfamethoxazole Approved Phase 2,Not Applicable 723-46-6 5329
30
Trimethoprim Approved, Vet_approved Phase 2,Not Applicable 738-70-5 5578
31
Ofloxacin Approved Phase 2,Not Applicable 82419-36-1 4583
32
Linezolid Approved, Investigational Phase 2 165800-03-3 441401
33
Clindamycin Approved, Vet_approved Phase 2,Not Applicable 18323-44-9 29029
34
Levofloxacin Approved, Investigational Phase 2,Not Applicable 100986-85-4 149096
35
Ciprofloxacin Approved, Investigational Phase 2,Not Applicable 85721-33-1 2764
36
Oxacillin Approved, Investigational Phase 2 66-79-5 6196
37
leucovorin Approved, Nutraceutical Phase 2,Not Applicable 58-05-9 143 6006
38
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2,Not Applicable 59-30-3 6037
39 Renal Agents Phase 2,Not Applicable
40 Fluoroquinolones Phase 2
41 Folic Acid Antagonists Phase 2,Not Applicable
42 Clindamycin palmitate Phase 2,Not Applicable
43 Clindamycin phosphate Phase 2,Not Applicable
44 Cytochrome P-450 Enzyme Inhibitors Phase 2,Not Applicable
45 Trimethoprim, Sulfamethoxazole Drug Combination Phase 2,Not Applicable
46 Vitamin B Complex Phase 2,Not Applicable
47 Antiparasitic Agents Phase 2,Not Applicable
48 Antiprotozoal Agents Phase 2,Not Applicable
49 Antimalarials Phase 2,Not Applicable
50 Fialuridine Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 52)
# Name Status NCT ID Phase Drugs
1 Rifampin Combination Therapy Versus Monotherapy in Early Staphylococcal Infections After Total Hip and Knee Arthroplasty Unknown status NCT00423982 Phase 4 Rifampin-combination therapy;Monotherapy
2 Visibility of Site Marking for Surgical Time Out With Two Different Skin Preparation Solutions Completed NCT00739583 Phase 4 CHG 2% w/v and IPA 70% v/v;Iodophor 0.7% and IPA 74% w/w
3 Efficacy and Safety of Intravenous Fosfomycin in Prosthetic Joint Infection Recruiting NCT03260010 Phase 4 Fosfomycin
4 Dalbavancin For The Treatment of Gram Positive Osteoarticular Infections Recruiting NCT03426761 Phase 4 Dalbavancin;Vancomycin
5 Daptomycin Use for Antimicrobial Prophylaxis in Methicillin Resistant Staphylococcus Aureus (MRSA) Colonized Adult Patients Undergoing Primary Elective Hip, Knee, or Shoulder Arthroplasty Terminated NCT01196169 Phase 4 Daptomycin;Vancomycin
6 Ceftaroline in the Treatment of Bone and Joint Infections Withdrawn NCT02005068 Phase 4 Ceftaroline
7 StaphVAX Immunogenicity in Orthopedic Implant Patients Completed NCT00211926 Phase 3
8 Local Gentamicin Application to Reduce Postoperative Infection Rate Completed NCT01287780 Phase 3
9 Treatment of the Infections on Osteo-articular Prostheses by 6 Versus 12 Weeks of Antibiotherapy Completed NCT01816009 Phase 3
10 Oral Sodium Fusidate (CEM-102) for the Treatment of Staphylococcal Bone or Joint Infections in Subjects for Whom Chronic Antibiotic Suppressive Therapy is Indicated Active, not recruiting NCT02569541 Phase 2, Phase 3 sodium fusidate
11 Daptomycin With Rifampin for Treatment of Staphylococcal Prosthetic Joint Infection Unknown status NCT01144000 Phase 2 Daptomycin
12 Efficacy and Safety Study of Antibiotic Treatment to Treat Hip Prosthetic Joint Infection Unknown status NCT01757236 Phase 2 VANCOMYCIN;CEFTRIAXONE;CLINDAMYCIN;SULFAMETHOXAZOLE AND TRIMETHOPRIM (CO-TRIMOXAZOLE);FLUOROQUINOLONE;LINEZOLID;RIFAMPIN
13 [124I]FIAU PET-CT Scanning in Patients With Pain in a Prosthetic Knee or Hip Joint Terminated NCT01705496 Phase 2
14 Safety and Efficacy of CEM-102 With Rifampin Compared to Standard Therapy in Patients With Prosthetic Joint Infections or Spacer Infection Terminated NCT01756924 Phase 2 CEM-102;IV or Oral standard of care antibiotics;Rifampin
15 Biodistribution and Dosimetry Evaluation of [124I]FIAU Completed NCT01337466 Phase 1
16 Causative Diagnosis on Prosthetic Joint Infections: Establishment of a Comprehensive Diagnostic Strategy Unknown status NCT01957228 Not Applicable
17 Short Interval in Treatment of PJI Unknown status NCT02372435 Not Applicable
18 Tissue Culture Versus Swab Culture in Prosthetic Joint Infections Unknown status NCT01482533
19 European Implant Cohort Study Unknown status NCT01633619
20 Bacterial Epidemiology and Empirical Antibiotherapy in Patients With Prosthetic Joint Infection Completed NCT03191292
21 One-stage Exchange Arthroplasty for Chronic Prosthetic Joint Infections Completed NCT03473392
22 The Influence of Antibiotic Prophylaxis on Intraoperative Prosthetic Joint Infection Cultures Completed NCT02413034 Not Applicable Cefazolin
23 The Utility of Levofloxacin-Rifampin in the Therapy of Prosthetic Joint Infection Completed NCT00279864
24 Molecular Microbiology in Osteo-arthritis Infection Completed NCT01193803
25 Static vs. Articulating Antibiotic Spacer for PJI in TKA Completed NCT02547129 Not Applicable
26 Efficacy of InteguSeal for Surgical Skin Preparation in Patients Undergoing Total Joint Replacement Completed NCT00829556 Not Applicable
27 Corynebacterium Spp Bone and Joint Infection: Retrospective Study of Microbiological, Diagnostic and Therapeutic Features Completed NCT03081273
28 Prosthetic Hip Infections: Prospective Study Completed NCT01963520
29 Pharmacokinetic Variability of Daptomycin During Prolonged Therapy for Bone and Joint Infections Completed NCT03209921
30 Daptomycin > 6 mg/kg/Day as Salvage Therapy in Patients With Complex Bone and Joint Infection: Cohort Study in a Regionalreference Center Completed NCT03209934
31 Bacterial Phenotype of Staphylococcus Aureus Has no Effect on Patients` Clinical Outcome in Orthopedic Device Related Bone Infections Completed NCT02971657
32 Biofilm Formation in Staphylococcus Epidermidis Associated Implant Infections Completed NCT02640937
33 Detection of Staph Colonization in Pre-op Arthroplasty Patients Completed NCT01648088
34 A Retrospective Observational Study to Evaluate the Utilization, Outcomes, and Adverse Events in Participants Treated With Orbactiv® (Oritavancin) for Infections Caused by Gram Positive Bacteria in a Real World Setting Completed NCT03159403 Oritavancin
35 Quality of Life in Patients Having a Prosthetic Joint Infection Recruiting NCT03307109
36 Bacteriological Setting Before Prosthesis Implantation With One Stage Surgery in Prosthetic Joint Infection Recruiting NCT02806063 Not Applicable
37 Cohort of Prosthetic Joint Infections Recruiting NCT02801253
38 Quality of Life Assessment in Patients Undergoing Prolonged Suppressive Antibiotherapy for Prosthetic Joint Infection. Recruiting NCT02805803 Not Applicable
39 Synovial Aspiration and Serological Testing in Two-stage Revision Arthroplasty of Prosthetic Joint Infection Recruiting NCT03038464
40 PRO-DIAG: Improved Diagnosis of Prosthetic Joint Infections Recruiting NCT03444571 Not Applicable
41 Microcurrent Dressing to Treat Infections, Before, During and After Surgery Recruiting NCT03156543 Not Applicable
42 Study of Antibiotic Spacer Design to Treat Infection After Hip Replacement Recruiting NCT01373099 Not Applicable
43 Articulating Versus Static Antibiotic Loaded Spacers for the Treatment of Prosthetic Knee Infection Recruiting NCT01373112 Not Applicable
44 Evaluation of the Antibiofilmogramme Test During Orthopaedic Device-Related Infection Recruiting NCT03263832
45 Intraoperative Microbial Contamination Recruiting NCT03139539 Not Applicable
46 Study of Hip and Knee Arthroplasty in South Africa Recruiting NCT03540667
47 The Utility of Next-generation Sequencing for the Diagnosis of Periprosthetic Joint Infection Enrolling by invitation NCT03200470
48 Fructosamine as a Predictor of Surgical Outcomes in Total Joint Arthroplasty A Prospective Multi-center Study Enrolling by invitation NCT03503019
49 European Prosthetic Joint Infection Cohort Study- Hip, Knee and Shoulder Prosthetic Joint Infection Not yet recruiting NCT02424903
50 Tedizolid Prolonged Treatment for Prosthetic Joint Infections Not yet recruiting NCT03378427 Not Applicable Tedizolid Phosphate 200 MG [Sivextro]

Search NIH Clinical Center for Prosthetic Joint Infection

Genetic Tests for Prosthetic Joint Infection

Anatomical Context for Prosthetic Joint Infection

MalaCards organs/tissues related to Prosthetic Joint Infection:

41
Bone, Testes, Colon, Skin, Kidney, Bone Marrow, Neutrophil

Publications for Prosthetic Joint Infection

Articles related to Prosthetic Joint Infection:

(show top 50) (show all 363)
# Title Authors Year
1
Histopathological Diagnosis of Prosthetic Joint Infection: does a threshold of 23 neutrophils do better than the classification of the periprosthetic membrane in a prospective multicenter study? ( 29976593 )
2018
2
Predicting Failure in Early Acute Prosthetic Joint Infection Treated With Debridement, Antibiotics, and Implant Retention: External Validation of the KLIC Score. ( 29691168 )
2018
3
<i>Staphylococcus epidermidis</i> isolates from nares and prosthetic joint infections are mupirocin susceptible. ( 29291157 )
2018
4
Two-Stage Revision Arthroplasty for the Treatment of Prosthetic Joint Infection. ( 29948954 )
2018
5
Peptostreptococcus canis and Bacteroides pyogenes prosthetic joint infection. ( 29895433 )
2018
6
Synovial aspiration and serological testing in two-stage revision arthroplasty for prosthetic joint infection: evaluation before reconstruction with a mean follow-up of twentyA sevenA months. ( 29243060 )
2018
7
Joint aspiration, including culture of reaspirated saline after a 'dry tap', is sensitive and specific for the diagnosis of hip and knee prosthetic joint infection. ( 29855250 )
2018
8
Correction to: The Kidney, Liver, Index surgery and C reactive protein score is a predictor of treatment response in acute prosthetic joint infection. ( 29164288 )
2018
9
Chronic and severe prosthetic joint infection complicated by amyloid A amyloidosis with renal and bladder impairment. ( 29437745 )
2018
10
Analysis of postoperative and hematogenous prosthetic joint-infection microbiological patterns in a large cohort. ( 29395369 )
2018
11
Cutibacterium acnes prosthetic joint infection: Diagnosis and treatment. ( 29203432 )
2018
12
Tubercular prosthetic joint infection: two case reports and literature review. ( 29086355 )
2018
13
CORR InsightsAr: Is Treatment With Dithiothreitol More Effective Than Sonication for the Diagnosis of Prosthetic Joint Infection? ( 29389799 )
2018
14
Short-term Complications After Revision Hip Arthroplasty forA Prosthetic Joint Infection Are Increased Relative to Noninfectious Revisions. ( 29853307 )
2018
15
Microbiologic epidemiology depending on time to occurrence of prosthetic joint infection: a prospective cohort study. ( 29803842 )
2018
16
Molecularly specific detection of bacterial lipoteichoic acid for diagnosis of prosthetic joint infection of the bone. ( 29707402 )
2018
17
Development and validation of baseline, perioperative and at-discharge predictive models for postsurgical prosthetic joint infection. ( 29715553 )
2018
18
Direct Detection and Identification of Prosthetic Joint Infection Pathogens in Synovial Fluid by Metagenomic Shotgun Sequencing. ( 29848568 )
2018
19
Serum IL-6 in combination with synovial IL-6/CRP shows excellent diagnostic power to detect hip and knee prosthetic joint infection. ( 29927991 )
2018
20
Successful treatment for acute prosthetic joint infection due to MRSA and <i>Candida albicans</i>: a case report and literature review. ( 29950850 )
2018
21
Genomic analysis of a Raoultella ornithinolytica strain causing prosthetic joint infection in an immunocompetent patient. ( 29930334 )
2018
22
Is Treatment With Dithiothreitol More Effective Than Sonication for the Diagnosis of Prosthetic Joint Infection? ( 29389758 )
2018
23
How Reliable Is the Cell Count Analysis in the Diagnosis of Prosthetic Joint Infection? ( 29887359 )
2018
24
Pre-operative asymptomatic bacteriuria: a risk factor for prosthetic joint infection? ( 29660385 )
2018
25
Intraoperative Considerations for Treatment/Prevention of Prosthetic Joint Infection. ( 29936680 )
2018
26
In vitro activity of oritavancin against biofilms of staphylococci isolated from prosthetic joint infection. ( 29885758 )
2018
27
CORR InsightsAr: Are Sonication Cultures of Antibiotic Cement Spacers Useful During Second-stage Reimplantation Surgery for Prosthetic Joint Infection? ( 29698308 )
2018
28
Outcome of acute staphylococcal prosthetic joint infection treated with debridement, implant retention and antimicrobial treatment with short duration of rifampicin. ( 29410124 )
2018
29
Corynebacterium striatum prosthetic joint infection. ( 29903503 )
2018
30
Alpha-defensin and the Synovasure lateral flow device for the diagnosis of prosthetic joint infection. ( 29855233 )
2018
31
Lactobacillus casei prosthetic joint infection. ( 29861314 )
2018
32
Predictors of revision, prosthetic joint infection and mortality following total hip or total knee arthroplasty in patients with rheumatoid arthritis: a nationwide cohort study using Danish healthcare registers. ( 29097373 )
2018
33
Systematic Review of Novel Synovial Fluid Markers and Polymerase Chain Reaction in the Diagnosis of Prosthetic Joint Infection. ( 28856346 )
2017
34
Diagnosis of prosthetic joint infection with alpha-defensin using a lateral flow device: a multicentre study. ( 28860397 )
2017
35
Non-compliance with IDSA guidelines for patients presenting with methicillin-susceptible Staphylococcus aureus prosthetic joint infection is a risk factor for treatment failure. ( 29122410 )
2017
36
Revision for prosthetic joint infection following hip arthroplasty: Evidence from the National Joint Registry. ( 28642256 )
2017
37
Prosthetic Joint Infection Following Invasive Dental Procedures and Antibiotic Prophylaxis in Patients With Hip or Knee Arthroplasty. ( 27825396 )
2017
38
Suppressive antibiotic therapy with oral doxycycline for Staphylococcus aureus prosthetic joint infection: a retrospective study of 39 patients. ( 28668689 )
2017
39
The Effect of Preoperative Antimicrobial Prophylaxis on Intraoperative Culture Results in Patients with a Suspected or Confirmed Prosthetic Joint Infection: a Systematic Review. ( 28659322 )
2017
40
Candida glabrata prosthetic joint infection, successfully treated with anidulafungin: A case report and review of the literature. ( 29272049 )
2017
41
Sonication contribution to identifying prosthetic joint infection with Ralstonia pickettii: a case report and review of the literature. ( 28724376 )
2017
42
Accuracy of different diagnostic tests for early, delayed and late prosthetic joint infection. ( 28841913 )
2017
43
First described case of prosthetic joint infection with Clostridium disporicum. ( 28673848 )
2017
44
Evaluation of the use of sonication of retrieved implants for the diagnosis of prosthetic joint infection in a routine setting. ( 29270861 )
2017
45
Prosthetic joint infection by Ruminococcus gnavus in a patient without associated digestive disease. ( 27931864 )
2017
46
Optimal Periprosthetic Tissue Specimen Number for Diagnosis of Prosthetic Joint Infection. ( 27807152 )
2017
47
Prosthetic Joint Infection following Total Hip Arthroplasty - Incidence, Mortality and Validation of the Diagnosis in the Danish Hip Arthroplasty Register. ( 28874245 )
2017
48
Editor's Spotlight/Take 5: Increased Mortality After Prosthetic Joint Infection in Primary THA. ( 28840486 )
2017
49
Synovial Fluid Leukocyte Esterase in the Diagnosis of Peri-Prosthetic Joint Infection: A Systematic Review and Meta-Analysis. ( 29099342 )
2017
50
Synovial Fluid I+-Defensin as a Biomarker for Peri-Prosthetic Joint Infection: A Systematic Review and Meta-Analysis. ( 28686144 )
2017

Variations for Prosthetic Joint Infection

Expression for Prosthetic Joint Infection

Search GEO for disease gene expression data for Prosthetic Joint Infection.

Pathways for Prosthetic Joint Infection

Pathways related to Prosthetic Joint Infection according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.6 IL1B MBL2 TLR2 TLR4 TNFRSF11B
2
Show member pathways
12.61 IL1B MBL2 TLR2 TLR4
3
Show member pathways
12.47 IL1B TLR2 TLR4
4
Show member pathways
12.46 IL1B TLR2 TLR4
5
Show member pathways
12.38 IL1B TLR2 TLR4
6
Show member pathways
12.18 IL1B TLR2 TLR4
7
Show member pathways
12.15 IL1B TLR2 TLR4
8
Show member pathways
11.97 IL1B TLR2 TLR4
9
Show member pathways
11.96 IL1B TLR2 TLR4
10 11.92 IL1B TLR2 TLR4
11
Show member pathways
11.83 IL1B TLR2 TLR4
12 11.76 MBL2 TLR2 TLR4
13
Show member pathways
11.64 IL1B TLR2 TLR4
14 11.61 IL1B TLR4
15 11.56 IL1B TLR4
16 11.55 TLR2 TLR4
17 11.48 IL1B TLR4
18 11.48 IL1B TLR2 TLR4
19 11.39 IL1B TLR2 TLR4
20 11.23 IL1B TNFRSF11B
21
Show member pathways
11.2 IL1B TNFRSF11B
22 11.1 IL1B TLR4
23 11.07 IL1B TLR2 TLR4
24 10.93 IL1B TLR2
25 10.82 IL1B TLR2 TLR4
26 10.48 IL1B TLR2 TLR4

GO Terms for Prosthetic Joint Infection

Cellular components related to Prosthetic Joint Infection according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.13 MBL2 TLR2 TLR4
2 intrinsic component of plasma membrane GO:0031226 8.62 TLR2 TLR4

Biological processes related to Prosthetic Joint Infection according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.83 IL1B TLR2 TNFRSF11B
2 immune system process GO:0002376 9.82 MBL2 TLR2 TLR4
3 innate immune response GO:0045087 9.81 MBL2 TLR2 TLR4
4 positive regulation of gene expression GO:0010628 9.79 IL1B TLR2 TLR4
5 immune response GO:0006955 9.71 IL1B TLR2 TLR4 TNFRSF11B
6 inflammatory response GO:0006954 9.67 IL1B TLR2 TLR4 TNFRSF11B
7 defense response to Gram-positive bacterium GO:0050830 9.65 MBL2 TLR2
8 apoptotic signaling pathway GO:0097190 9.64 TLR4 TNFRSF11B
9 cellular response to mechanical stimulus GO:0071260 9.63 IL1B TLR4
10 positive regulation of inflammatory response GO:0050729 9.62 TLR2 TLR4
11 positive regulation of JNK cascade GO:0046330 9.62 IL1B TLR4
12 positive regulation of tumor necrosis factor production GO:0032760 9.61 TLR2 TLR4
13 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.61 IL1B TLR2 TLR4
14 toll-like receptor signaling pathway GO:0002224 9.6 TLR2 TLR4
15 positive regulation of interferon-gamma production GO:0032729 9.59 IL1B TLR4
16 positive regulation of nitric oxide biosynthetic process GO:0045429 9.58 IL1B TLR4
17 positive regulation of phagocytosis GO:0050766 9.58 IL1B MBL2
18 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.57 TLR2 TLR4
19 positive regulation of interferon-beta production GO:0032728 9.56 TLR2 TLR4
20 positive regulation of interleukin-12 production GO:0032735 9.55 TLR2 TLR4
21 positive regulation of interleukin-10 production GO:0032733 9.54 TLR2 TLR4
22 positive regulation of chemokine production GO:0032722 9.52 TLR2 TLR4
23 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.51 TLR2 TLR4
24 positive regulation of interleukin-6 production GO:0032755 9.5 IL1B TLR2 TLR4
25 I-kappaB phosphorylation GO:0007252 9.49 TLR2 TLR4
26 regulation of cytokine secretion GO:0050707 9.48 TLR2 TLR4
27 cellular response to lipoteichoic acid GO:0071223 9.46 TLR2 TLR4
28 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.43 IL1B TLR2 TLR4
29 lipopolysaccharide-mediated signaling pathway GO:0031663 9.33 IL1B TLR2 TLR4
30 response to lipopolysaccharide GO:0032496 9.26 IL1B TLR2 TLR4 TNFRSF11B
31 positive regulation of interleukin-8 production GO:0032757 8.8 IL1B TLR2 TLR4

Molecular functions related to Prosthetic Joint Infection according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide binding GO:0001530 9.16 TLR2 TLR4
2 signaling receptor activity GO:0038023 9.13 TLR2 TLR4 TNFRSF11B
3 lipopolysaccharide receptor activity GO:0001875 8.62 TLR2 TLR4

Sources for Prosthetic Joint Infection

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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