PJI
MCID: PRS115
MIFTS: 42

Prosthetic Joint Infection (PJI)

Categories: Rare diseases

Aliases & Classifications for Prosthetic Joint Infection

MalaCards integrated aliases for Prosthetic Joint Infection:

Name: Prosthetic Joint Infection 52 71
Joint Replacement Infection 52
Artificial Joint Infection 52
Knee Replacement Infection 52
Pji 52

Classifications:



External Ids:

UMLS 71 C0410808

Summaries for Prosthetic Joint Infection

NIH Rare Diseases : 52 A prosthetic joint infection (PJI) is a rare complication of joint replacement surgery, also known as arthroplasty. Arthroplasty is done to help relieve pain and restore function in a severely diseased joint, such as a knee, hip or shoulder. Approximately 0.5 to 1 percent of people with replacement joints develop a PJI. Infections can occur early in the course of recovery from joint replacement surgery (within the first two months) or much later. Signs and symptoms of PJI include fever, chills, drainage from the surgical site, and increasing redness, tenderness, swelling and pain of the affected joint. Prosthetic joint infections are often hard to treat because of the development of a structure called a biofilm within the joint. A biofilm develops when bacteria adhere to the solid surface of the artificial joint. The biofilm can act as a kind of shield to some of the bacteria, making it difficult for the bacteria to be found and destroyed by the body's defenses or by antibiotic medications. An infected joint replacement usually requires surgery to remove the artificial parts and potent antibiotics to kill the bacteria.

MalaCards based summary : Prosthetic Joint Infection, also known as joint replacement infection, is related to clostridium difficile colitis and endocarditis. An important gene associated with Prosthetic Joint Infection is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and Toll-like Receptor Signaling Pathway. The drugs Iodine and Fosfomycin have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and skin, and related phenotypes are cardiovascular system and hematopoietic system

Related Diseases for Prosthetic Joint Infection

Diseases related to Prosthetic Joint Infection via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 431)
# Related Disease Score Top Affiliating Genes
1 clostridium difficile colitis 30.2 IL1B CRP
2 endocarditis 30.2 TLR2 IL6 CRP
3 septic arthritis 30.1 TLR4 TLR2 CRP
4 infective endocarditis 29.9 TLR2 IL6 CRP
5 pharyngitis 29.8 IL6 IL1B CRP
6 coccidioidomycosis 29.7 TLR4 MBL2
7 bone resorption disease 29.7 TNFRSF11B IL6 CRP
8 arthropathy 29.6 TNFRSF11B IL6 IL1B CRP
9 osteoarthritis 29.6 TNFRSF11B IL6 IL1B CRP
10 brucellosis 29.6 TLR4 IL6 CRP
11 osteomyelitis 29.4 TLR4 TLR2 IL6 IL1B
12 autoimmune disease 29.2 MBL2 IL6 IL1B CRP
13 bacteriuria 29.2 TLR4 TLR2 IL6 CRP
14 lyme disease 29.1 TLR2 IL6 IL1B CRP
15 acute cystitis 28.9 TLR4 TLR2 IL6 CRP
16 mycobacterium tuberculosis 1 28.8 TLR4 TLR2 MBL2 CRP
17 myeloma, multiple 28.7 TNFRSF11B TLR4 IL6 CRP
18 colitis 28.6 TLR4 TLR2 IL6 IL1B
19 arthritis 28.6 TLR4 TLR2 IL6 IL1B CRP
20 tularemia 28.5 TLR4 TLR2 MBL2 IL6
21 listeriosis 28.5 TLR4 TLR2 MBL2 IL6
22 q fever 28.4 TLR4 TLR2 MBL2 IL6 IL1B
23 toxic shock syndrome 28.2 TLR4 TLR2 IL6 IL1B CRP
24 peritonitis 28.2 TLR4 TLR2 IL6 IL1B CRP
25 pulmonary disease, chronic obstructive 28.2 TLR4 TLR2 IL6 IL1B CRP
26 thrombocytopenia 28.2 TLR4 TLR2 IL6 IL1B CRP
27 proteasome-associated autoinflammatory syndrome 1 28.1 TLR4 TLR2 IL6 IL1B CRP
28 bacterial infectious disease 28.0 TLR4 TLR2 MBL2 IL6 IL1B CRP
29 meningitis 27.8 TLR4 TLR2 MBL2 IL6 IL1B CRP
30 bone inflammation disease 27.6 TNFRSF11B TLR4 TLR2 IL6 IL1B CRP
31 pneumonia 27.6 TLR4 TLR2 MBL2 IL6 IL1B CRP
32 rheumatoid arthritis 27.2 TNFRSF11B TLR4 TLR2 MBL2 IL6 IL1B
33 juvenile polyposis syndrome 11.5
34 cervical adenitis 10.3 IL1B CRP
35 cold agglutinin disease 10.3 IL6 CRP
36 wells syndrome 10.3 IL1B CRP
37 cardiogenic shock 10.3 IL6 CRP
38 gingival recession 10.3 IL1B CRP
39 cryopyrin-associated periodic syndrome 10.3 IL6 CRP
40 systemic autoimmune disease 10.3 IL6 CRP
41 schnitzler syndrome 10.3 IL1B CRP
42 paratyphoid fever 10.3 IL1B CRP
43 generalized atherosclerosis 10.3 IL6 CRP
44 aortitis 10.3 IL6 CRP
45 hypopyon 10.3 IL6 CRP
46 acute cholangitis 10.3 IL6 CRP
47 tenosynovitis 10.3 IL6 CRP
48 pyuria 10.3 IL6 CRP
49 scleral disease 10.3 IL6 CRP
50 osteosclerotic myeloma 10.3 IL6 IL1B

Graphical network of the top 20 diseases related to Prosthetic Joint Infection:



Diseases related to Prosthetic Joint Infection

Symptoms & Phenotypes for Prosthetic Joint Infection

MGI Mouse Phenotypes related to Prosthetic Joint Infection:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.73 CRP IL1B IL6 TLR2 TLR4 TNFRSF11B
2 hematopoietic system MP:0005397 9.63 IL1B IL6 MBL2 TLR2 TLR4 TNFRSF11B
3 immune system MP:0005387 9.5 CRP IL1B IL6 MBL2 TLR2 TLR4
4 skeleton MP:0005390 9.1 IL1B IL6 MBL2 TLR2 TLR4 TNFRSF11B

Drugs & Therapeutics for Prosthetic Joint Infection

Drugs for Prosthetic Joint Infection (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 75)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iodine Approved, Investigational Phase 4 7553-56-2 807
2
Fosfomycin Approved Phase 4 23155-02-4 446987
3
Cefepime Approved, Investigational Phase 4 88040-23-7 5479537
4
Vancomycin Approved Phase 4 1404-90-6 441141 14969
5
Daptomycin Approved, Investigational Phase 4 103060-53-3 16129629
6 Dermatologic Agents Phase 4
7 Chlorhexidine gluconate Phase 4
8 Disinfectants Phase 4
9 Anti-Infective Agents, Local Phase 4
10 cadexomer iodine Phase 4
11 Antitubercular Agents Phase 4
12 Pharmaceutical Solutions Phase 4
13 Calamus Phase 4
14 Anti-Infective Agents Phase 4
15 Anti-Bacterial Agents Phase 4
16 Antibiotics, Antitubercular Phase 4
17 methicillin Phase 4
18 Vaccines Phase 3
19 Immunologic Factors Phase 3
20 Gentamicins Phase 3
21
leucovorin Approved Phase 2 58-05-9 6006 143
22
Tobramycin Approved, Investigational Phase 2 32986-56-4 5496 36294
23
Rifampicin Approved Phase 2 13292-46-1 5458213 5381226
24
Ceftriaxone Approved Phase 2 73384-59-5 5479530 5361919
25
Levofloxacin Approved, Investigational Phase 2 100986-85-4 149096
26
Linezolid Approved, Investigational Phase 2 165800-03-3 441401
27
Ofloxacin Approved Phase 2 82419-36-1 4583
28
Cefazolin Approved Phase 2 25953-19-9 656510 33255
29
Ceftaroline fosamil Approved, Investigational Phase 2 229016-73-3
30
Ciprofloxacin Approved, Investigational Phase 2 85721-33-1 2764
31
Oxacillin Approved, Investigational Phase 2 66-79-5 6196
32
Fusidic Acid Approved, Investigational Phase 2 6990-06-3 3000226
33
Nafcillin Approved, Investigational Phase 2 147-52-4, 985-16-0 8982
34
Folic acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
35 Fialuridine Investigational Phase 2 69123-98-4
36 Antiparasitic Agents Phase 2
37 Folic Acid Antagonists Phase 2
38 Vitamin B Complex Phase 2
39 Vitamin B9 Phase 2
40 Folate Phase 2
41 Antiprotozoal Agents Phase 2
42 Fluoroquinolones Phase 2
43 Antimalarials Phase 2
44 Cytochrome P-450 CYP3A Inducers Phase 2
45 Antiviral Agents Phase 2
46 Trimethoprim, Sulfamethoxazole Drug Combination Phase 2
47
Zinc Approved, Investigational 7440-66-6 32051
48
Piperacillin Approved 66258-76-2 43672
49
Tazobactam Approved 89786-04-9 123630
50
Cimetidine Approved, Investigational 51481-61-9 2756

Interventional clinical trials:

(show top 50) (show all 66)
# Name Status NCT ID Phase Drugs
1 Visibility of Site Marking for Surgical Time Out With Two Different Skin Preparation Solutions Completed NCT00739583 Phase 4 CHG 2% w/v and IPA 70% v/v;Iodophor 0.7% and IPA 74% w/w
2 Efficacy and Safety of Intravenous Fosfomycin in Prosthetic Joint Infection (PJI) Caused by Staphylococci, Streptococci, Enterococci and Gram-negative Bacilli, Including Mixed Infections and Culture Negative PJI's ("PROOF-Study") Recruiting NCT03260010 Phase 4 Fosfomycin
3 Intraosseous Vancomycin in Primary Total Hip Arthroplasty - Designing a Protocol Not yet recruiting NCT04042233 Phase 4 Experimental Intraosseous vancomycin 500mg in 250 mL NS;Standard IV administration of vancomycin
4 How to Improve the Results of Irrigation and Debridement for PJI Through the Use of Intraosseous Antibiotics Not yet recruiting NCT03713528 Phase 4 Intraoperative Intraosseous Vancomycin
5 Daptomycin Use For Prophylaxis In Prosthetic Joint Surgery, A Randomized Prospective Study Comparing The Efficacy Of Daptomycin Versus Vancomycin For Peri-Operative Antibiotic Prophylaxis In MRSA Colonized Adult Patients Undergoing Primary Elective Hip, Knee or Shoulder Arthroplasty Terminated NCT01196169 Phase 4 Daptomycin;Vancomycin
6 A Multicenter, Randomized, Placebo-Controlled, Double-Blinded Study to Evaluate Safety and Immunogenicity of StaphVAX®, a Bivalent Staphylococcus Aureus Glycoconjugate Vaccine, in Adult Patients Receiving an Orthopaedic Prosthetic Implant Completed NCT00211926 Phase 3
7 Local Gentamicin Application to Reduce Postoperative Infection Rate in Hemiarthroplasty After Fracture of the Proximal Femur: a Randomized Controlled Trial Completed NCT01287780 Phase 3
8 Efficacy and Safety of Daptomycin (With or Without Rifampin) in the Treatment of Staphylococcal Hip, Knee and Shoulder Prosthetic Joint Infection Unknown status NCT01144000 Phase 2 Daptomycin
9 Prospective,Randomized,Open Label,European Multicenter Study of the Efficacy of the Linezolid-rifampin Combination Versus Standard of Care in the Treatment of Gram-positive. Unknown status NCT01757236 Phase 2 VANCOMYCIN;CEFTRIAXONE;CLINDAMYCIN;SULFAMETHOXAZOLE AND TRIMETHOPRIM (CO-TRIMOXAZOLE);FLUOROQUINOLONE;LINEZOLID;RIFAMPIN
10 A Phase 2 Multicenter Feasibility Trial to Evaluate Safety and Efficacy in Patients Treated for Hip or Knee Prosthetic Joint Infection With Alternating Irrigation of Vancomycin HCl and Tobramycin Sulfate in Two-Stage Exchange Arthroplasty Active, not recruiting NCT03721328 Phase 2
11 Sensitivity and Specificity of [124I]FIAU PET-CT Scanning in Patients Presenting With Pain in a Prosthetic Knee or Hip Joint Terminated NCT01705496 Phase 2
12 Safety and Efficacy of CEM-102 With Rifampin Compared to Standard Therapy in Patients With Prosthetic Joint Infections or Spacer Infection Terminated NCT01756924 Phase 2 CEM-102;IV or Oral standard of care antibiotics;Rifampin
13 Biodistribution and Dosimetry of [124i]FIAU in Patients With Prosthetic Joint Infection of The Knee or Hip and Healthy Subjects Using PET-CT Scanning Completed NCT01337466 Phase 1
14 Tissue Culture Versus Swab Culture in Prosthetic Joint Infections Unknown status NCT01482533
15 Benefit of Synovial Aspiration and Serological Testing in Two-stage Revision Arthroplasty of Prosthetic Joint Infection Unknown status NCT03038464
16 Efficacy and Safety of Fast-track Treatment for Prosthetic Joint Infection (PJI) Unknown status NCT02372435
17 The Utility of Next-generation Sequencing for the Diagnosis of Periprosthetic Joint Infection Unknown status NCT03200470
18 European Prosthetic Joint Infection Cohort Study (EPJIC): Evaluation of the Treatment Approach for Hip, Knee and Shoulder Prosthetic Joint Revision Surgery Unknown status NCT02424903
19 Does the Selection of Patients Helps Healing the Infection After Change in One Step of a Knee Replacement? Unknown status NCT02405702
20 European Implant Cohort Study Unknown status NCT01633619
21 Cost of Failure Following Reimplantation After a 2-stage Exchange Strategy for Hip or Knee Prosthetic Joint Infection Completed NCT03612076
22 Staphylococcal Acute Post-Operative Prosthetic Joint Infection Treated With 'DAIR' (Debridement and Implant Retention) And Impact Of Rifampin: A Retrospective Cohort Study In France Completed NCT03750721
23 One-stage Exchange Arthroplasty for Chronic Prosthetic Joint Infections Completed NCT03473392
24 Microbiological Epidemiology in Patients Experiencing Microbiological or Clinical Failure Following Reimplantation After a 2-stage Exchange Strategy for Hip or Knee Prosthetic Joint Infection Completed NCT03627000
25 Bacterial Epidemiology and Empirical Antibiotherapy in Patients With Prosthetic Joint Infection Completed NCT03191292
26 Bacteriological Setting Before Prosthesis Implantation With One Stage Surgery in Prosthetic Joint Infection Completed NCT02806063
27 Corynebacterium Spp Bone and Joint Infection: Retrospective Study of Microbiological, Diagnostic and Therapeutic Features Completed NCT03081273
28 Prosthesis Infection and One-step Exchange: Pretreatment by Targeted Antibiotic Therapy in Completed NCT03848091
29 Single-Center, Randomized Trial to Study the Efficacy of InteguSeal for Surgical Skin Preparation in Patients Undergoing Completed NCT00829556
30 Pharmacokinetic Variability of Daptomycin During Prolonged Therapy for Bone and Joint Infections Completed NCT03209921
31 Prolonged Oral Levofloxacin-Rifampin for Staphylococcus Aureus Prosthetic Joint Infection (PJI) Treated With Debridement And Retention Of Components: A Prospective Observational Cohort Study. Mayo PJI Study Group (MPSG)* Completed NCT00279864
32 Rapid Diagnosis of Prosthetic Joint Infection by Matrix-assisted Laser Desorption Ionization Time-of-flight Mass Spectrometry Completed NCT03717090
33 Daptomycin > 6 mg/kg/Day as Salvage Therapy in Patients With Complex Bone and Joint Infection: Cohort Study in a Regionalreference Center Completed NCT03209934
34 Enhanced Detection of Staphylococcus Aureus Colonization in Patients Undergoing Prosthetic Joint Implantation. Completed NCT01648088
35 Early Clinical Results of Mobile-Bearing Revision Total Knee Arthroplasty Completed NCT01398800
36 Evaluation of a Microcurrent Dressing for Prophylaxis Against Perioperative Prosthetic Joint Infection Completed NCT03156543
37 The Influence of Antibiotic Prophylaxis on Intraoperative Prosthetic Joint Infection Cultures Completed NCT02413034 Cefazolin
38 Use of an Occlusive Skin Closure System May Reduce Post-operative Wound Drainage After Tumor Arthroplasty of the Hip Completed NCT03746717
39 Bacterial Phenotype of Staphylococcus Aureus Has no Effect on Patients` Clinical Outcome in Orthopedic Device Related Bone Infections Completed NCT02971657
40 Interest of Molecular Biology for Diagnostic of Osteo-arthritis Infections. EE Observational Prospective Study Completed NCT01193803
41 Biofilm Formation Increases Treatment Failure in Staphylococcus Epidermidis Device-related Osteomyelitis in Human Patients Completed NCT02640937
42 Intraoperative Microbial Contamination, Its Prevention and Its Consequences for Outcomes Following Joint Replacement Surgery Completed NCT03139539
43 Retrospective Study to Identify the Incidence, Risk Factors and Outcomes of Prosthetic Joint Infection Due to Staphylococcus Aureus After Primary Knee or Hip Joint Replacement Recruiting NCT03826108
44 Comparison of the Tolerance of Vancomycin in Combination With Piperacillin/Tazobactam or Cefepim as Empirical Antimicrobial Therapy of Prosthetic Joint Infection Recruiting NCT03850860
45 Relationship Between Severe Intraoperative Hyperglycemia and Infections Within 7 Days After Orthopedic Surgery Recruiting NCT03903354
46 Quality of Life Assessment in Patients Undergoing Prolonged Suppressive Antibiotherapy for Prosthetic Joint Infection. Recruiting NCT02805803
47 Prospective Cohort of Patients With Prosthetic Joint Infection Recruiting NCT02801253
48 Utility of Alpha Defensin and 16S rRNA Gene in Diagnosis of Prosthetic Joint Infection Recruiting NCT03714165
49 Quality of Life in Patients Having a Prosthetic Joint Infection Recruiting NCT03307109
50 Consitution Of A Biological Collection From Samples From The Gut Microbiote In Patients Having A Bone Or Joint Infection Treated By A Suppressive Subcutaneous Antibiotherapy With Betalactamine Recruiting NCT03611634

Search NIH Clinical Center for Prosthetic Joint Infection

Genetic Tests for Prosthetic Joint Infection

Anatomical Context for Prosthetic Joint Infection

MalaCards organs/tissues related to Prosthetic Joint Infection:

40
Bone, Testes, Skin, Liver, Colon, Kidney, Lung

Publications for Prosthetic Joint Infection

Articles related to Prosthetic Joint Infection:

(show top 50) (show all 1184)
# Title Authors PMID Year
1
Risk factors for periprosthetic joint infection of the hip and knee. 61
31432657 2020
2
Endovascular preoperative embolization for temporomandibular joint replacement surgery. 61
31594444 2020
3
Prolonged suppressive antibiotic therapy is successful in the management of prosthetic joint infection. 61
31578679 2020
4
Micro-organisms and risk factors associated with prosthetic joint infection following primary total knee replacement-our experience in Pakistan. 61
31863160 2020
5
Re: 'Microbiological epidemiology depending on time to occurrence of prosthetic joint infection' by Triffault-Fillit et al. 61
31473327 2020
6
Is there scientific evidence to support antibiotic prophylaxis in patients with periodontal disease as a means to decrease the risk of prosthetic joint infections? A systematic review. 61
31754752 2020
7
Addressing Antibiotic Hip Spacer Instability via Hybrid Screw-cement Fixation of a Constrained Liner and Cement-rebar Interface Techniques: A Technical Narrative. 61
31567542 2020
8
Radiographic Evidence of Soft-Tissue Gas 14 Days After Total Knee Arthroplasty Is Predictive of Early Prosthetic Joint Infection. 61
31573855 2020
9
New developments and future challenges in prevention, diagnosis, and treatment of prosthetic joint infection. 61
31965585 2020
10
Incidence, temporal trends and potential risk factors for prosthetic joint infection after primary total shoulder and elbow replacement: Systematic review and meta-analysis. 61
31981635 2020
11
Tularemia in a Prosthetic Joint Infection. 61
31269216 2020
12
Synergy between induction heating, antibiotics, and N-acetylcysteine eradicates Staphylococcus aureus from biofilm. 61
31986930 2020
13
Experimental reproduction of periprosthetic joint infection: Developing a representative animal model. 61
31982249 2020
14
Preoperative Vitamin D Repletion in Total Knee Arthroplasty: A Cost-Effectiveness Model. 61
31983566 2019
15
Short or Long Antibiotic Regimes in Orthopaedics (SOLARIO): a randomised controlled open-label non-inferiority trial of duration of systemic antibiotics in adults with orthopaedic infection treated operatively with local antibiotic therapy. 61
31815653 2019
16
Real-world experience with dalbavancin therapy in gram-positive skin and soft tissue infection, bone and joint infection. 61
31520397 2019
17
Levofloxacin-induced rhabdomyolysis in a patient on concurrent atorvastatin: Case report and literature review. 61
31407828 2019
18
Mycobacterium bovis prosthetic joint infection following intravesical instillation of BCG for bladder cancer. 61
31857290 2019
19
Prosthetic joint infection: an extremely rare complication of intravesicular BCG therapy. 61
31826907 2019
20
Cost-Effectiveness of Alternative Anticoagulation Strategies for Postoperative Management of Total Knee Arthroplasty Patients. 61
30369093 2019
21
Plasma Viscosity Has a Role in the Diagnosis of Prosthetic Joint Infection After Total Knee Arthroplasty. 61
31447253 2019
22
Patient-reported outcomes after above-knee amputation for prosthetic joint infection. 61
31806507 2019
23
Risk factors, diagnosis and management of prosthetic joint infection after total hip arthroplasty. 61
31752561 2019
24
An unexpected pathogen causing prosthetic joint infection following screening colonoscopy. 61
31886384 2019
25
Peri-Prosthetic Joint Infection after Finger Joint Arthroplasty. 61
31855128 2019
26
[111 INDIUM LABELED LEUKOCYTE SCINTIGRAPHY IS A LOW SENSITIVITY TEST FOR DIAGNOSING PROSTHETIC JOINT INFECTION IN EQUIVOCAL CASES]. 61
31823532 2019
27
Laminar flow does not affect risk of prosthetic joint infection after primary total knee replacement in Asian patients. 61
31877337 2019
28
Genotypic and phenotypic changes of Staphylococcus epidermidis during relapse episodes in prosthetic joint infections. 61
31828715 2019
29
Diagnosis of peripheral bone and prosthetic joint infections: overview on the consensus documents by the EANM, EBJIS, and ESR (with ESCMID endorsement). 61
31250170 2019
30
Staphylococcus aureus Bloodstream Infection in Patients With Prosthetic Joints in the Prospective VIRSTA Cohort Study: Frequency and Time of Occurrence of Periprosthetic Joint Infection. 61
31890721 2019
31
Systematic review of the outcome of cemented versus uncemented total hip arthroplasty following pelvic irradiation. 61
30937859 2019
32
The Right Time to Safely Re-Evaluate Empirical Antimicrobial Treatment of Hip or Knee Prosthetic Joint Infections. 61
31810267 2019
33
Leukocyte esterase strip test as a reliable intraoperative PJIs biomarker. Our experience. 61
31821283 2019
34
Dalbavancin for treating prosthetic joint infections caused by Gram-positive bacteria: A proposal for a low dose strategy. A retrospective cohort study. 61
31642637 2019
35
Implant retention and high rate of treatment failure in hematogenous acute knee and hip prosthetic joint infections. 61
31848104 2019
36
Serum interleukin 6 could be a valuable initial diagnostic tool in prosthetic knee joint infections. 61
31350652 2019
37
The Role of Long-Term Antibiotic Suppression in the Management of Peri-Prosthetic Joint Infections Treated With Debridement, Antibiotics, and Implant Retention: A Systematic Review. 61
31955984 2019
38
Surveillance of life-long antibiotics-A cross-sectional cohort study assessing patient attitudes and understanding of long-term antibiotic consumption. 61
31229453 2019
39
The serum level of D-Dimer is not suitable for distinguishing between prosthetic joint infection and aseptic loosening. 61
31783874 2019
40
A sophisticated antibiotic-loading protocol in articulating cement spacers for the treatment of prosthetic joint infection: A retrospective cohort study. 61
31832172 2019
41
Pharmacokinetics of flucloxacillin during prolonged intermittent renal replacement therapy in a 76-year-old man. 61
31650900 2019
42
Preoperative Depression Is Associated With Increased Risk Following Revision Total Joint Arthroplasty. 61
31848077 2019
43
Prosthetic joint infection caused by Mycobacterium avium complex. 61
31764970 2019
44
Implant materials and prosthetic joint infection: the battle with the biofilm. 61
31754470 2019
45
Dual prophylaxis with teicoplanin and cefazolin in the prevention of prosthetic joint infection. 61
30876673 2019
46
Prosthetic joint infection. 61
31832177 2019
47
Risk of Recurrent Staphylococcus aureus Prosthetic Joint Infection in Rheumatoid Arthritis Patients-A Nationwide Cohort Study. 61
31737738 2019
48
Postoperative Infection in Cementless and Cemented Total Knee Arthroplasty: A Propensity Score Matched Analysis. 61
30754069 2019
49
Designing a customized clinical practice guideline regarding antibiotic prophylaxis for Iranian general dentists. 61
31590651 2019
50
Historical evolution of the diseases caused by non-pigmented rapidly growing mycobacteria in a University Hospital. 61
31535542 2019

Variations for Prosthetic Joint Infection

Expression for Prosthetic Joint Infection

Search GEO for disease gene expression data for Prosthetic Joint Infection.

Pathways for Prosthetic Joint Infection

Pathways related to Prosthetic Joint Infection according to GeneCards Suite gene sharing:

(show all 42)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.71 TNFRSF11B TLR4 TLR2 MBL2 IL6 IL1B
2
Show member pathways
12.84 TLR4 TLR2 MBL2 IL6 IL1B
3
Show member pathways
12.73 TLR4 TLR2 IL6 IL1B
4
Show member pathways
12.62 TLR4 TLR2 IL6 IL1B
5
Show member pathways
12.51 TLR4 TLR2 IL6 IL1B
6
Show member pathways
12.41 TLR4 TLR2 IL6 IL1B
7
Show member pathways
12.4 TLR4 TLR2 IL6 IL1B
8
Show member pathways
12.37 TNFRSF11B TLR4 TLR2 IL1B
9
Show member pathways
12.18 TLR2 IL6 IL1B
10
Show member pathways
12.17 IL6 IL1B CRP
11
Show member pathways
12.15 TLR4 IL6 IL1B
12 12.14 TLR4 IL6 IL1B
13
Show member pathways
12.11 TLR4 TLR2 IL6
14
Show member pathways
12.1 TLR4 TLR2 IL1B
15 12.08 TLR4 IL6 IL1B
16
Show member pathways
12.05 TLR2 IL6 IL1B
17 12.02 TLR4 TLR2 IL6
18 11.99 TLR4 TLR2 IL6 IL1B
19 11.98 TLR4 TLR2 MBL2
20
Show member pathways
11.92 TLR4 TLR2 IL6 IL1B
21
Show member pathways
11.87 TLR4 TLR2 IL1B
22 11.85 TLR4 IL6 IL1B
23 11.85 TLR4 IL6 IL1B
24
Show member pathways
11.78 TLR4 TLR2 IL6 IL1B
25
Show member pathways
11.72 TLR4 TLR2 IL6 IL1B
26 11.63 TLR4 IL6 IL1B
27 11.58 TLR4 IL6 IL1B
28 11.57 TLR4 TLR2 IL6 IL1B
29 11.43 TLR4 TLR2 IL6 IL1B
30 11.35 TLR4 TLR2 IL1B
31
Show member pathways
11.32 TNFRSF11B IL1B
32 11.31 TNFRSF11B IL6 IL1B
33 11.25 IL6 IL1B
34 11.23 IL6 IL1B
35 11.18 IL6 IL1B
36 11.18 TLR4 IL6 IL1B
37 11.16 IL6 IL1B
38 11.13 IL6 IL1B
39 11.06 TLR2 IL1B
40 11.01 TLR4 TLR2 IL6 IL1B
41 10.92 IL6 CRP
42 10.62 TLR4 TLR2 IL6 IL1B

GO Terms for Prosthetic Joint Infection

Cellular components related to Prosthetic Joint Infection according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 TNFRSF11B MBL2 IL6 IL1B CRP
2 intrinsic component of plasma membrane GO:0031226 8.96 TLR4 TLR2

Biological processes related to Prosthetic Joint Infection according to GeneCards Suite gene sharing:

(show all 37)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.06 TNFRSF11B TLR4 TLR2 IL6 IL1B
2 innate immune response GO:0045087 9.91 TLR4 TLR2 MBL2 CRP
3 immune response GO:0006955 9.89 TLR4 TLR2 IL6 IL1B
4 cellular response to lipopolysaccharide GO:0071222 9.81 TLR4 IL6 IL1B
5 response to lipopolysaccharide GO:0032496 9.8 TLR4 TLR2 IL1B
6 positive regulation of gene expression GO:0010628 9.72 TLR4 TLR2 IL6 IL1B CRP
7 positive regulation of inflammatory response GO:0050729 9.71 TLR4 TLR2 IL1B
8 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.7 TLR4 TLR2 IL1B
9 positive regulation of nitric oxide biosynthetic process GO:0045429 9.67 TLR4 IL1B
10 positive regulation of interferon-gamma production GO:0032729 9.67 TLR4 IL1B
11 toll-like receptor signaling pathway GO:0002224 9.67 TLR4 TLR2
12 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.67 TLR4 TLR2 IL6 IL1B
13 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.66 TLR4 TLR2
14 positive regulation of vascular endothelial growth factor production GO:0010575 9.65 IL6 IL1B
15 negative regulation of neurogenesis GO:0050768 9.65 IL6 IL1B
16 positive regulation of interleukin-12 production GO:0032735 9.65 TLR4 TLR2
17 acute-phase response GO:0006953 9.65 MBL2 IL6 CRP
18 inflammatory response GO:0006954 9.65 TLR4 TLR2 IL6 IL1B CRP
19 positive regulation of interferon-beta production GO:0032728 9.64 TLR4 TLR2
20 positive regulation of interleukin-10 production GO:0032733 9.64 TLR4 TLR2
21 positive regulation of interleukin-6 secretion GO:2000778 9.63 TLR4 TLR2 IL1B
22 positive regulation of glial cell proliferation GO:0060252 9.62 IL6 IL1B
23 positive regulation of interleukin-8 secretion GO:2000484 9.62 TLR4 TLR2
24 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.61 TLR4 TLR2
25 lipopolysaccharide-mediated signaling pathway GO:0031663 9.61 TLR4 TLR2 IL1B
26 negative regulation of bone resorption GO:0045779 9.6 TNFRSF11B IL6
27 positive regulation of neuroinflammatory response GO:0150078 9.58 IL6 IL1B
28 I-kappaB phosphorylation GO:0007252 9.58 TLR4 TLR2
29 positive regulation of interleukin-8 production GO:0032757 9.58 TLR4 TLR2 IL1B
30 cellular response to lipoteichoic acid GO:0071223 9.57 TLR4 TLR2
31 negative regulation of lipid storage GO:0010888 9.56 IL6 CRP
32 opsonization GO:0008228 9.55 MBL2 CRP
33 positive regulation of matrix metallopeptidase secretion GO:1904466 9.51 TLR4 TLR2
34 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.49 TLR4 TLR2
35 positive regulation of chemokine production GO:0032722 9.33 TLR4 TLR2 IL6
36 defense response to Gram-positive bacterium GO:0050830 9.26 TLR2 MBL2 IL6 CRP
37 positive regulation of interleukin-6 production GO:0032755 8.92 TLR4 TLR2 IL6 IL1B

Molecular functions related to Prosthetic Joint Infection according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 9.33 TNFRSF11B TLR4 TLR2
2 lipopolysaccharide binding GO:0001530 9.26 TLR4 TLR2
3 cytokine activity GO:0005125 9.13 TNFRSF11B IL6 IL1B
4 lipopolysaccharide receptor activity GO:0001875 8.62 TLR4 TLR2

Sources for Prosthetic Joint Infection

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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