PJI
MCID: PRS115
MIFTS: 46

Prosthetic Joint Infection (PJI)

Categories: Rare diseases

Aliases & Classifications for Prosthetic Joint Infection

MalaCards integrated aliases for Prosthetic Joint Infection:

Name: Prosthetic Joint Infection 53 73
Joint Replacement Infection 53
Artificial Joint Infection 53
Knee Replacement Infection 53
Pji 53

Classifications:



External Ids:

UMLS 73 C0410808

Summaries for Prosthetic Joint Infection

NIH Rare Diseases : 53 A prosthetic joint infection (PJI) is a rare complication of joint replacement surgery, also known as arthroplasty.  Arthroplasty is done to help relieve pain and restore function in a severely diseased joint, such as a knee, hip or shoulder.  Approximately 0.5 to 1 percent of people with replacement joints develop a PJI.  Infections can occur early in the course of recovery from joint replacement surgery (within the first two months) or much later.  Signs and symptoms of PJI include fever, chills, drainage from the surgical site, and increasing redness, tenderness, swelling and pain of the affected joint.  Prosthetic joint infections are often hard to treat because of the development of a structure called a biofilm within the joint. A biofilm develops when bacteria adhere to the solid surface of the artificial joint. The biofilm can act as a kind of shield to some of the bacteria, making it difficult for the bacteria to be found and destroyed by the body's defenses or by antibiotic medications. An infected joint replacement usually requires surgery to remove the artificial parts and potent antibiotics to kill the bacteria. 

MalaCards based summary : Prosthetic Joint Infection, also known as joint replacement infection, is related to septic arthritis and coccidioidomycosis. An important gene associated with Prosthetic Joint Infection is IL1B (Interleukin 1 Beta), and among its related pathways/superpathways are Innate Immune System and Toll-like Receptor Signaling Pathway. The drugs Cloxacillin and Rifampicin have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and colon, and related phenotypes are hematopoietic system and immune system

Related Diseases for Prosthetic Joint Infection

Diseases related to Prosthetic Joint Infection via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 108)
# Related Disease Score Top Affiliating Genes
1 septic arthritis 29.9 TLR2 TLR4
2 coccidioidomycosis 29.9 MBL2 TLR4
3 rheumatoid arthritis 29.8 IL1B TLR2 TLR4 TNFRSF11B
4 q fever 29.7 IL1B TLR2 TLR4
5 lyme disease 29.7 IL1B TLR2
6 mycobacterium tuberculosis 1 29.4 MBL2 TLR2 TLR4
7 pneumonia 29.4 IL1B MBL2 TLR2 TLR4
8 juvenile polyposis syndrome 11.3
9 arthritis 10.3
10 osteomyelitis 10.2
11 campylobacteriosis 10.1 IL1B TLR4
12 endocarditis 10.1
13 bacteriuria 10.1
14 endometrial disease 10.1 IL1B TLR4
15 cysticercosis 10.1 IL1B TLR4
16 root resorption 10.1 IL1B TNFRSF11B
17 perinatal necrotizing enterocolitis 10.1 IL1B TLR4
18 extrinsic cardiomyopathy 10.1 IL1B TLR4
19 idiopathic neutropenia 10.1 IL1B TLR4
20 pyelonephritis 10.1 IL1B TLR4
21 typhoid fever 10.1 IL1B TLR4
22 salmonellosis 10.1 IL1B TLR4
23 vulvar vestibulitis syndrome 10.1 IL1B MBL2
24 aggressive periodontitis 10.1 IL1B TLR4
25 meningococcemia 10.1 IL1B MBL2
26 chorioamnionitis 10.1 IL1B TLR4
27 lymphadenitis 10.0 IL1B TLR4
28 bone inflammation disease 10.0 IL1B TNFRSF11B
29 spondyloarthropathy 1 10.0 TLR4 TNFRSF11B
30 aortic aneurysm, familial abdominal, 1 10.0 IL1B TNFRSF11B
31 eosinophilic pneumonia 10.0
32 mycobacterium fortuitum 10.0
33 synovitis 10.0 IL1B TNFRSF11B
34 intestinal disease 10.0 IL1B TLR4
35 mouth disease 10.0 IL1B TLR4
36 cerebral palsy 10.0 IL1B MBL2
37 haemophilus influenzae 10.0 IL1B TLR2
38 congenital cytomegalovirus 10.0 IL1B TLR2
39 primary systemic mycosis 10.0 IL1B TLR2
40 trench fever 10.0 TLR2 TLR4
41 aphthous stomatitis 10.0 IL1B TLR2
42 pertussis 10.0 IL1B TLR4
43 fungal keratitis 10.0 TLR2 TLR4
44 acute cervicitis 10.0 TLR2 TLR4
45 anterior uveitis 10.0 TLR2 TLR4
46 penicilliosis 10.0 TLR2 TLR4
47 myositis fibrosa 10.0 TLR2 TLR4
48 leptospirosis 10.0 IL1B TLR2
49 spondylarthropathy 10.0 TLR2 TLR4
50 parasitic protozoa infectious disease 10.0 IL1B TLR2

Graphical network of the top 20 diseases related to Prosthetic Joint Infection:



Diseases related to Prosthetic Joint Infection

Symptoms & Phenotypes for Prosthetic Joint Infection

MGI Mouse Phenotypes related to Prosthetic Joint Infection:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.35 IL1B MBL2 TLR2 TLR4 TNFRSF11B
2 immune system MP:0005387 9.02 IL1B MBL2 TLR2 TLR4 TNFRSF11B

Drugs & Therapeutics for Prosthetic Joint Infection

Drugs for Prosthetic Joint Infection (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 69)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cloxacillin Approved, Investigational, Vet_approved Phase 4 61-72-3 6098
2
Rifampicin Approved Phase 4,Phase 2,Not Applicable 13292-46-1 5458213 5381226
3
Vancomycin Approved Phase 4,Phase 2,Not Applicable 1404-90-6 14969 441141
4
Daptomycin Approved, Investigational Phase 4,Phase 2 103060-53-3 16129629
5
Iodine Approved, Investigational Phase 4,Not Applicable 7553-56-2 807
6
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
7
Cefazolin Approved Phase 4,Phase 2,Not Applicable 25953-19-9 656510 33255
8
Fosfomycin Approved Phase 4 23155-02-4 446987
9
Nafcillin Approved, Investigational Phase 4,Phase 2 985-16-0, 147-52-4 8982
10
Teicoplanin Approved, Investigational Phase 4,Not Applicable 61036-62-2
11
Dalbavancin Approved, Investigational Phase 4 91097-81-3, 171500-79-1 122186
12 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable
13 Cytochrome P-450 CYP3A Inducers Phase 4,Phase 2
14 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 2
15 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Not Applicable
16 methicillin Phase 4
17 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
18 Antitubercular Agents Phase 4,Phase 3,Phase 2,Not Applicable
19 Dermatologic Agents Phase 4
20 cadexomer iodine Phase 4,Not Applicable
21 Pharmaceutical Solutions Phase 4
22 Anti-Infective Agents, Local Phase 4
23 Chlorhexidine gluconate Phase 4
24 Disinfectants Phase 4
25 Calamus Phase 4
26
Fusidic Acid Approved, Investigational Phase 2, Phase 3,Not Applicable 6990-06-3 3000226
27 Vaccines Phase 3
28 Immunologic Factors Phase 3
29 Gentamicins Phase 3
30
Linezolid Approved, Investigational Phase 2 165800-03-3 441401
31
Clindamycin Approved, Vet_approved Phase 2,Not Applicable 18323-44-9 29029
32
Levofloxacin Approved, Investigational Phase 2,Not Applicable 100986-85-4 149096
33
Sulfamethoxazole Approved Phase 2,Not Applicable 723-46-6 5329
34
Trimethoprim Approved, Vet_approved Phase 2,Not Applicable 738-70-5 5578
35
Ceftriaxone Approved Phase 2 73384-59-5 5479530 5361919
36
leucovorin Approved Phase 2,Not Applicable 58-05-9 6006 143
37
Ofloxacin Approved Phase 2,Not Applicable 82419-36-1 4583
38
Tobramycin Approved, Investigational Phase 2,Not Applicable 32986-56-4 36294 5496
39
Ciprofloxacin Approved, Investigational Phase 2,Not Applicable 85721-33-1 2764
40
Oxacillin Approved, Investigational Phase 2 66-79-5 6196
41
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2,Not Applicable 59-30-3 6037
42 Antiparasitic Agents Phase 2,Not Applicable
43 Vitamin B Complex Phase 2,Not Applicable
44 Cytochrome P-450 Enzyme Inhibitors Phase 2,Not Applicable
45 Anti-Infective Agents, Urinary Phase 2,Not Applicable
46 Folic Acid Antagonists Phase 2,Not Applicable
47 Renal Agents Phase 2,Not Applicable
48 Antiprotozoal Agents Phase 2,Not Applicable
49 Clindamycin palmitate Phase 2,Not Applicable
50 Antimalarials Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 65)
# Name Status NCT ID Phase Drugs
1 Rifampin Combination Therapy Versus Monotherapy in Early Staphylococcal Infections After Total Hip and Knee Arthroplasty Unknown status NCT00423982 Phase 4 Rifampin-combination therapy;Monotherapy
2 Visibility of Site Marking for Surgical Time Out With Two Different Skin Preparation Solutions Completed NCT00739583 Phase 4 CHG 2% w/v and IPA 70% v/v;Iodophor 0.7% and IPA 74% w/w
3 Efficacy and Safety of Intravenous Fosfomycin in Prosthetic Joint Infection Recruiting NCT03260010 Phase 4 Fosfomycin
4 Dalbavancin For The Treatment of Gram Positive Osteoarticular Infections Recruiting NCT03426761 Phase 4 Dalbavancin;Vancomycin
5 Efficacy and Tolerance of 4 Weeks of Tedizolid in Prosthetic Joint Infections Treated With Implant Removal Not yet recruiting NCT03746327 Phase 4 Sivextro 200 milligrams Oral Tablet
6 How to Improve the Results of Irrigation and Debridement for PJI Through the Use of Intraosseous Antibiotics Not yet recruiting NCT03713528 Phase 4 Intraoperative Intraosseous Vancomycin
7 Daptomycin Use for Antimicrobial Prophylaxis in Methicillin Resistant Staphylococcus Aureus (MRSA) Colonized Adult Patients Undergoing Primary Elective Hip, Knee, or Shoulder Arthroplasty Terminated NCT01196169 Phase 4 Daptomycin;Vancomycin
8 Ceftaroline in the Treatment of Bone and Joint Infections Withdrawn NCT02005068 Phase 4 Ceftaroline
9 StaphVAX Immunogenicity in Orthopedic Implant Patients Completed NCT00211926 Phase 3
10 Local Gentamicin Application to Reduce Postoperative Infection Rate Completed NCT01287780 Phase 3
11 Treatment of the Infections on Osteo-articular Prostheses by 6 Versus 12 Weeks of Antibiotherapy Completed NCT01816009 Phase 3
12 Oral Sodium Fusidate (CEM-102) for the Treatment of Staphylococcal Bone or Joint Infections in Subjects for Whom Chronic Antibiotic Suppressive Therapy is Indicated Active, not recruiting NCT02569541 Phase 2, Phase 3 sodium fusidate
13 Daptomycin With Rifampin for Treatment of Staphylococcal Prosthetic Joint Infection Unknown status NCT01144000 Phase 2 Daptomycin
14 Efficacy and Safety Study of Antibiotic Treatment to Treat Hip Prosthetic Joint Infection Unknown status NCT01757236 Phase 2 VANCOMYCIN;CEFTRIAXONE;CLINDAMYCIN;SULFAMETHOXAZOLE AND TRIMETHOPRIM (CO-TRIMOXAZOLE);FLUOROQUINOLONE;LINEZOLID;RIFAMPIN
15 Safety and Efficacy in Patients Treated for Hip or Knee PJI With Vancomycin and Tobramycin Joint Irrigation Recruiting NCT03721328 Phase 2
16 [124I]FIAU PET-CT Scanning in Patients With Pain in a Prosthetic Knee or Hip Joint Terminated NCT01705496 Phase 2
17 Safety and Efficacy of CEM-102 With Rifampin Compared to Standard Therapy in Patients With Prosthetic Joint Infections or Spacer Infection Terminated NCT01756924 Phase 2 CEM-102;IV or Oral standard of care antibiotics;Rifampin
18 Biodistribution and Dosimetry Evaluation of [124I]FIAU Completed NCT01337466 Phase 1
19 European Prosthetic Joint Infection Cohort Study- Hip, Knee and Shoulder Prosthetic Joint Infection Unknown status NCT02424903
20 Causative Diagnosis on Prosthetic Joint Infections: Establishment of a Comprehensive Diagnostic Strategy Unknown status NCT01957228 Not Applicable
21 Short Interval in Treatment of PJI Unknown status NCT02372435 Not Applicable
22 Tissue Culture Versus Swab Culture in Prosthetic Joint Infections Unknown status NCT01482533
23 European Implant Cohort Study Unknown status NCT01633619
24 Cost Of Failure Following Reimplantation After a 2-Stage Exchange Strategy For Hip Or Knee Prosthetic Joint Infection Completed NCT03612076
25 Bacteriological Setting Before Prosthesis Implantation With One Stage Surgery in Prosthetic Joint Infection Completed NCT02806063 Not Applicable
26 Bacterial Epidemiology and Empirical Antibiotherapy in Patients With Prosthetic Joint Infection Completed NCT03191292
27 One-stage Exchange Arthroplasty for Chronic Prosthetic Joint Infections Completed NCT03473392
28 The Influence of Antibiotic Prophylaxis on Intraoperative Prosthetic Joint Infection Cultures Completed NCT02413034 Not Applicable Cefazolin
29 The Utility of Levofloxacin-Rifampin in the Therapy of Prosthetic Joint Infection Completed NCT00279864
30 Microbiological Epidemiology in Patients Experiencing Microbiological or Clinical Failure Following Reimplantation After a 2-stage Exchange Strategy for Hip or Knee Prosthetic Joint Infection Completed NCT03627000
31 Staphylococcal Acute Post-Operative PJI Treated With 'DAIR' And Impact Of Rifampin Completed NCT03750721
32 Molecular Microbiology in Osteo-arthritis Infection Completed NCT01193803
33 Static vs. Articulating Antibiotic Spacer for PJI in TKA Completed NCT02547129 Not Applicable
34 Efficacy of InteguSeal for Surgical Skin Preparation in Patients Undergoing Total Joint Replacement Completed NCT00829556 Not Applicable
35 Corynebacterium Spp Bone and Joint Infection: Retrospective Study of Microbiological, Diagnostic and Therapeutic Features Completed NCT03081273
36 Prosthetic Hip Infections: Prospective Study Completed NCT01963520
37 Pharmacokinetic Variability of Daptomycin During Prolonged Therapy for Bone and Joint Infections Completed NCT03209921
38 Intraoperative Microbial Contamination Completed NCT03139539 Not Applicable
39 Daptomycin > 6 mg/kg/Day as Salvage Therapy in Patients With Complex Bone and Joint Infection: Cohort Study in a Regionalreference Center Completed NCT03209934
40 Bacterial Phenotype of Staphylococcus Aureus Has no Effect on Patients` Clinical Outcome in Orthopedic Device Related Bone Infections Completed NCT02971657
41 Biofilm Formation in Staphylococcus Epidermidis Associated Implant Infections Completed NCT02640937
42 Detection of Staph Colonization in Pre-op Arthroplasty Patients Completed NCT01648088
43 A Retrospective Observational Study to Evaluate the Utilization, Outcomes, and Adverse Events in Participants Treated With Orbactiv® (Oritavancin) for Infections Caused by Gram Positive Bacteria in a Real World Setting Completed NCT03159403 Oritavancin
44 Quality of Life in Patients Having a Prosthetic Joint Infection Recruiting NCT03307109
45 Rapid Diagnosis of Prosthetic Joint Infection by Matrix-assisted Laser Desorption Recruiting NCT03717090
46 Cohort of Prosthetic Joint Infections Recruiting NCT02801253
47 Alpha Defensin and 16S rRNA Gene in Diagnosis of PJI Recruiting NCT03714165
48 Quality of Life Assessment in Patients Undergoing Prolonged Suppressive Antibiotherapy for Prosthetic Joint Infection. Recruiting NCT02805803 Not Applicable
49 Synovial Aspiration and Serological Testing in Two-stage Revision Arthroplasty of Prosthetic Joint Infection Recruiting NCT03038464
50 New Strategies for Biofilm Related Infections Recruiting NCT03784807

Search NIH Clinical Center for Prosthetic Joint Infection

Genetic Tests for Prosthetic Joint Infection

Anatomical Context for Prosthetic Joint Infection

MalaCards organs/tissues related to Prosthetic Joint Infection:

41
Bone, Testes, Colon, Skin, Kidney, Bone Marrow, Lung

Publications for Prosthetic Joint Infection

Articles related to Prosthetic Joint Infection:

(show top 50) (show all 470)
# Title Authors Year
1
Histopathological Diagnosis of Prosthetic Joint Infection: does a threshold of 23 neutrophils do better than the classification of the periprosthetic membrane in a prospective multicenter study? ( 29976593 )
2018
2
Predicting Failure in Early Acute Prosthetic Joint Infection Treated With Debridement, Antibiotics, and Implant Retention: External Validation of the KLIC Score. ( 29691168 )
2018
3
Two-Stage Revision Arthroplasty for the Treatment of Prosthetic Joint Infection. ( 29948954 )
2018
4
Peptostreptococcus canis and Bacteroides pyogenes prosthetic joint infection. ( 29895433 )
2018
5
Synovial aspiration and serological testing in two-stage revision arthroplasty for prosthetic joint infection: evaluation before reconstruction with a mean follow-up of twentyA sevenA months. ( 29243060 )
2018
6
Joint aspiration, including culture of reaspirated saline after a 'dry tap', is sensitive and specific for the diagnosis of hip and knee prosthetic joint infection. ( 29855250 )
2018
7
Correction to: The Kidney, Liver, Index surgery and C reactive protein score is a predictor of treatment response in acute prosthetic joint infection. ( 29164288 )
2018
8
Chronic and severe prosthetic joint infection complicated by amyloid A amyloidosis with renal and bladder impairment. ( 29437745 )
2018
9
Analysis of postoperative and hematogenous prosthetic joint-infection microbiological patterns in a large cohort. ( 29395369 )
2018
10
Cutibacterium acnes prosthetic joint infection: Diagnosis and treatment. ( 29203432 )
2018
11
Tubercular prosthetic joint infection: two case reports and literature review. ( 29086355 )
2018
12
CORR InsightsAr: Is Treatment With Dithiothreitol More Effective Than Sonication for the Diagnosis of Prosthetic Joint Infection? ( 29389799 )
2018
13
Short-term Complications After Revision Hip Arthroplasty forA Prosthetic Joint Infection Are Increased Relative to Noninfectious Revisions. ( 29853307 )
2018
14
Microbiologic epidemiology depending on time to occurrence of prosthetic joint infection: a prospective cohort study. ( 29803842 )
2018
15
Molecularly specific detection of bacterial lipoteichoic acid for diagnosis of prosthetic joint infection of the bone. ( 29707402 )
2018
16
Development and validation of baseline, perioperative and at-discharge predictive models for postsurgical prosthetic joint infection. ( 29715553 )
2018
17
Direct Detection and Identification of Prosthetic Joint Infection Pathogens in Synovial Fluid by Metagenomic Shotgun Sequencing. ( 29848568 )
2018
18
Serum IL-6 in combination with synovial IL-6/CRP shows excellent diagnostic power to detect hip and knee prosthetic joint infection. ( 29927991 )
2018
19
Successful treatment for acute prosthetic joint infection due to MRSA and <i>Candida albicans</i>: a case report and literature review. ( 29950850 )
2018
20
Genomic analysis of a Raoultella ornithinolytica strain causing prosthetic joint infection in an immunocompetent patient. ( 29930334 )
2018
21
Is Treatment With Dithiothreitol More Effective Than Sonication for the Diagnosis of Prosthetic Joint Infection? ( 29389758 )
2018
22
How Reliable Is the Cell Count Analysis in the Diagnosis of Prosthetic Joint Infection? ( 29887359 )
2018
23
Pre-operative asymptomatic bacteriuria: a risk factor for prosthetic joint infection? ( 29660385 )
2018
24
Intraoperative Considerations for Treatment/Prevention of Prosthetic Joint Infection. ( 29936680 )
2018
25
In vitro activity of oritavancin against biofilms of staphylococci isolated from prosthetic joint infection. ( 29885758 )
2018
26
CORR InsightsAr: Are Sonication Cultures of Antibiotic Cement Spacers Useful During Second-stage Reimplantation Surgery for Prosthetic Joint Infection? ( 29698308 )
2018
27
Outcome of acute staphylococcal prosthetic joint infection treated with debridement, implant retention and antimicrobial treatment with short duration of rifampicin. ( 29410124 )
2018
28
Corynebacterium striatum prosthetic joint infection. ( 29903503 )
2018
29
Alpha-defensin and the Synovasure lateral flow device for the diagnosis of prosthetic joint infection. ( 29855233 )
2018
30
In vitro antibacterial activity of bioactive glass S53P4 on multiresistant pathogens causing osteomyelitis and prosthetic joint infection. ( 29614973 )
2018
31
Staphylococcus aureus Evasion of Host Immunity in the Setting of Prosthetic Joint Infection: Biofilm and Beyond. ( 29987645 )
2018
32
Evaluation of Oritavancin Combinations with Rifampin, Gentamicin, or Linezolid against Prosthetic Joint Infection-Associated Methicillin-Resistant Staphylococcus aureus Biofilms by Time-Kill Assays. ( 30012765 )
2018
33
Treatment of Prosthetic Joint Infection with Debridement, Antibiotics and Irrigation with Implant Retention - a Narrative Review. ( 30013891 )
2018
34
Utility of 16S rRNA PCR in the Synovial Fluid for the Diagnosis of Prosthetic Joint Infection. ( 30027708 )
2018
35
Prospective Cohort Study of the Tolerability of Prosthetic Joint Infection Empirical Antimicrobial Therapy. ( 30038037 )
2018
36
In vitro activity of oritavancin in combination with rifampin or gentamicin against prosthetic joint infection-associated methicillin-resistant Staphylococcus epidermidis biofilms. ( 30048689 )
2018
37
Risk factors associated with revision for prosthetic joint infection after hip replacement: a prospective observational cohort study. ( 30056097 )
2018
38
New Diagnostic Tools for Prosthetic Joint Infection. ( 30056239 )
2018
39
Success Rate of Fungal Peri-Prosthetic Joint Infection Treated by 2-Stage Revision and Potential Risk Factors of Treatment Failure: A Retrospective Study. ( 30093606 )
2018
40
Combination of conventional culture, vial culture, and broad-range PCR of sonication fluid for the diagnosis of prosthetic joint infection. ( 30099992 )
2018
41
Pasteurella multocida prosthetic joint infection. ( 30105206 )
2018
42
Fusobacterium nucleatum prosthetic hip infection: Case report and review of the literature of unusual anaerobic prosthetic joint infection. ( 30118892 )
2018
43
Prosthetic joint infection caused by Candida lusitaniae: report of a unique case. ( 30136635 )
2018
44
Mouse model of Gram-negative prosthetic joint infection reveals therapeutic targets. ( 30185667 )
2018
45
Prosthetic Joint Infection from Carbapenemase-Resistant Klebsiella pneumoniae Successfully Treated with Ceftazidime-Avibactam. ( 30186645 )
2018
46
Small-colony variant of Staphylococcus lugdunensis in prosthetic joint infection. ( 30186900 )
2018
47
The incidence rate, trend and microbiological aetiology of prosthetic joint infection after total knee arthroplasty: A 13 years' experience from a tertiary medical center in Taiwan. ( 30228089 )
2018
48
State-of-the-art diagnosis and surgical treatment of acute peri-prosthetic joint infection following primary total hip arthroplasty. ( 30233819 )
2018
49
Prosthetic Joint Infection Update. ( 30241717 )
2018
50
Protective effect of N-acetylcysteine in prosthetic joint infection: A nationwide population-based cohort study. ( 30253996 )
2018

Variations for Prosthetic Joint Infection

Expression for Prosthetic Joint Infection

Search GEO for disease gene expression data for Prosthetic Joint Infection.

Pathways for Prosthetic Joint Infection

Pathways related to Prosthetic Joint Infection according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.6 IL1B MBL2 TLR2 TLR4 TNFRSF11B
2
Show member pathways
12.66 IL1B MBL2 TLR2 TLR4
3
Show member pathways
12.46 IL1B TLR2 TLR4
4
Show member pathways
12.39 IL1B TLR2 TLR4
5
Show member pathways
12.28 IL1B TLR2 TLR4
6
Show member pathways
12.09 IL1B TLR2 TLR4 TNFRSF11B
7
Show member pathways
11.98 IL1B TLR2 TLR4
8 11.95 IL1B TLR2 TLR4
9
Show member pathways
11.9 IL1B TLR2 TLR4
10
Show member pathways
11.89 IL1B TLR2 TLR4
11 11.84 MBL2 TLR2 TLR4
12
Show member pathways
11.75 IL1B TLR2 TLR4
13
Show member pathways
11.71 IL1B TLR2 TLR4
14
Show member pathways
11.67 IL1B TLR2 TLR4
15 11.61 IL1B TLR4
16 11.56 IL1B TLR4
17 11.55 TLR2 TLR4
18 11.53 IL1B TLR2 TLR4
19 11.49 IL1B TLR4
20 11.45 IL1B TLR2 TLR4
21 11.24 IL1B TNFRSF11B
22
Show member pathways
11.21 IL1B TNFRSF11B
23 11.1 IL1B TLR4
24 11.07 IL1B TLR2 TLR4
25 10.95 IL1B TLR2
26 10.82 IL1B TLR2 TLR4
27 10.48 IL1B TLR2 TLR4

GO Terms for Prosthetic Joint Infection

Cellular components related to Prosthetic Joint Infection according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.13 MBL2 TLR2 TLR4
2 intrinsic component of plasma membrane GO:0031226 8.62 TLR2 TLR4

Biological processes related to Prosthetic Joint Infection according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.95 IL1B TLR2 TLR4 TNFRSF11B
2 apoptotic process GO:0006915 9.83 IL1B TLR2 TNFRSF11B
3 immune system process GO:0002376 9.82 MBL2 TLR2 TLR4
4 innate immune response GO:0045087 9.8 MBL2 TLR2 TLR4
5 immune response GO:0006955 9.79 IL1B TLR2 TLR4
6 positive regulation of gene expression GO:0010628 9.79 IL1B TLR2 TLR4
7 inflammatory response GO:0006954 9.77 IL1B TLR2 TLR4
8 cellular response to interferon-gamma GO:0071346 9.65 TLR2 TLR4
9 defense response to Gram-positive bacterium GO:0050830 9.65 MBL2 TLR2
10 response to lipopolysaccharide GO:0032496 9.65 IL1B TLR2 TLR4
11 positive regulation of JNK cascade GO:0046330 9.64 IL1B TLR4
12 cellular response to mechanical stimulus GO:0071260 9.63 IL1B TLR4
13 positive regulation of inflammatory response GO:0050729 9.63 TLR2 TLR4
14 positive regulation of tumor necrosis factor production GO:0032760 9.61 TLR2 TLR4
15 positive regulation of interferon-gamma production GO:0032729 9.59 IL1B TLR4
16 positive regulation of nitric oxide biosynthetic process GO:0045429 9.58 IL1B TLR4
17 positive regulation of phagocytosis GO:0050766 9.58 IL1B MBL2
18 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.58 IL1B TLR2 TLR4
19 toll-like receptor signaling pathway GO:0002224 9.57 TLR2 TLR4
20 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.56 TLR2 TLR4
21 positive regulation of interferon-beta production GO:0032728 9.55 TLR2 TLR4
22 positive regulation of interleukin-12 production GO:0032735 9.54 TLR2 TLR4
23 positive regulation of interleukin-10 production GO:0032733 9.52 TLR2 TLR4
24 positive regulation of chemokine production GO:0032722 9.51 TLR2 TLR4
25 positive regulation of interleukin-6 production GO:0032755 9.5 IL1B TLR2 TLR4
26 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.49 TLR2 TLR4
27 regulation of cytokine secretion GO:0050707 9.46 TLR2 TLR4
28 I-kappaB phosphorylation GO:0007252 9.43 TLR2 TLR4
29 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.43 IL1B TLR2 TLR4
30 cellular response to lipoteichoic acid GO:0071223 9.37 TLR2 TLR4
31 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.16 TLR2 TLR4
32 lipopolysaccharide-mediated signaling pathway GO:0031663 9.13 IL1B TLR2 TLR4
33 positive regulation of interleukin-8 production GO:0032757 8.8 IL1B TLR2 TLR4

Molecular functions related to Prosthetic Joint Infection according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide binding GO:0001530 9.16 TLR2 TLR4
2 signaling receptor activity GO:0038023 9.13 TLR2 TLR4 TNFRSF11B
3 lipopolysaccharide receptor activity GO:0001875 8.62 TLR2 TLR4

Sources for Prosthetic Joint Infection

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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