MCID: PRT025
MIFTS: 28

Protein-Deficiency Anemia

Categories: Blood diseases, Immune diseases

Aliases & Classifications for Protein-Deficiency Anemia

MalaCards integrated aliases for Protein-Deficiency Anemia:

Name: Protein-Deficiency Anemia 12 15
Anemia Due to Protein Deficiency 12 70
Protein-Deficiency Anaemia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13120
ICD9CM 34 281.4
SNOMED-CT 67 85746008
ICD10 32 D53.0
UMLS 70 C0154290

Summaries for Protein-Deficiency Anemia

MalaCards based summary : Protein-Deficiency Anemia, also known as anemia due to protein deficiency, is related to deficiency anemia and vitamin b12- and folate-independent constitutional megaloblastic anemia. An important gene associated with Protein-Deficiency Anemia is GH2 (Growth Hormone 2), and among its related pathways/superpathways are PEDF Induced Signaling and TGF-Beta Pathway. Affiliated tissues include pituitary, bone marrow and pancreas.

Related Diseases for Protein-Deficiency Anemia

Diseases related to Protein-Deficiency Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Related Disease Score Top Affiliating Genes
1 deficiency anemia 29.6 INS GH2 GH1 F2
2 vitamin b12- and folate-independent constitutional megaloblastic anemia 10.3
3 isolated growth hormone deficiency type iii 10.1 GH2 GH1
4 diencephalic neoplasm 10.1 GH2 GH1
5 pyridoxine deficiency anemia 10.0 IGFBP1 F2
6 laron syndrome 10.0 IGFBP1 GH1
7 cavernous sinus thrombosis 9.9 INS F2
8 mediastinitis 9.9 INS F2
9 paralytic ileus 9.9 INS F2
10 ileus 9.9 INS F2
11 marasmus 9.9 INS GH1
12 hypothalamic disease 9.9 INS GH1
13 kwashiorkor 9.9 INS F2
14 pituitary apoplexy 9.9 INS GH1
15 empty sella syndrome 9.9 INS GH1
16 esophageal varix 9.9 INS F2
17 aromatase deficiency 9.9 INS GH1
18 aspiration pneumonia 9.9 INS F2
19 cellulitis 9.9 INS F2
20 hepatic vascular disease 9.9 INS F2
21 vein disease 9.8 INS F2
22 metal metabolism disorder 9.8 INS F2
23 acute cystitis 9.8 INS F2
24 nephrosclerosis 9.8 INS F2
25 acanthosis nigricans 9.8 INS GH1
26 islet cell tumor 9.8 INS GH1
27 hyperproinsulinemia 9.8 INS IGFBP1
28 diabetes insipidus 9.8 INS GH1
29 hyperprolactinemia 9.8 INS GH1
30 alcoholic liver cirrhosis 9.8 INS F2
31 persistent fetal circulation syndrome 9.8 INS IGFBP1
32 autoimmune disease of gastrointestinal tract 9.8 INS F2
33 placenta disease 9.8 INS F2
34 portal hypertension 9.8 INS F2
35 uremia 9.8 INS GH1
36 anovulation 9.8 INS IGFBP1
37 craniopharyngioma 9.8 INS GH1
38 hypopituitarism 9.8 INS GH1
39 hyperandrogenism 9.8 INS IGFBP1
40 hyperthyroidism 9.7 INS GH1
41 chronic fatigue syndrome 9.7 INS IGFBP1
42 nutritional deficiency disease 9.7 IGFBP1 GH1 F2
43 abdominal obesity-metabolic syndrome 1 9.7 INS IGFBP1
44 viral hepatitis 9.7 INS F2
45 microvascular complications of diabetes 1 9.7 INS IGFBP1
46 primary hyperparathyroidism 9.7 INS IGFBP1
47 diencephalic astrocytoma 9.7 INS GH2 GH1
48 hyperpituitarism 9.6 INS GH2 GH1
49 adermatoglyphia 9.6 INS GH2 GH1
50 pituitary gland disease 9.6 INS GH2 GH1

Comorbidity relations with Protein-Deficiency Anemia via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia

Graphical network of the top 20 diseases related to Protein-Deficiency Anemia:



Diseases related to Protein-Deficiency Anemia

Symptoms & Phenotypes for Protein-Deficiency Anemia

Drugs & Therapeutics for Protein-Deficiency Anemia

Search Clinical Trials , NIH Clinical Center for Protein-Deficiency Anemia

Genetic Tests for Protein-Deficiency Anemia

Anatomical Context for Protein-Deficiency Anemia

MalaCards organs/tissues related to Protein-Deficiency Anemia:

40
Pituitary, Bone Marrow, Pancreas, Liver, Ovary, Placenta

Publications for Protein-Deficiency Anemia

Articles related to Protein-Deficiency Anemia:

(show all 16)
# Title Authors PMID Year
1
Treatment of Protein Malnutrition and Uncontrollable Diarrhea Following Bilio-pancreatic Diversion with Pancreas Extract Viokase. 61
10757934 1993
2
The role of mucosal iron binding proteins in adaptation of iron absorption during protein deficiency and rehabilitation. 61
684293 1978
3
[Study of protein-deficiency anemia]. 61
4841503 1974
4
[Tocopherol and protein deficiency anemia]. 61
4573690 1972
5
[Behavior of the bone marrow in experimental protein deficiency anemia under treatment with anabolic steroids]. 61
6026725 1967
6
STUDIES ON THE HEMOLYTIC NATURE OF PROTEIN-DEFICIENCY ANEMIA IN THE RAT. 61
14194271 1964
7
[Experimental anemia due to protein deficiency: current status of the question]. 61
13965140 1963
8
[The effect of anabolic steroids on protein-deficiency anemia in rats]. 61
13981512 1963
9
[Research on the role of the reduction of tissue oxygen requirements in the origin of protein deficiency anemia]. 61
13862776 1961
10
[The clinical incidence of protein-deficiency anemia of pregnancy]. 61
13825898 1959
11
[Analytic study of iron metabolism in normal and pathological conditions. Clinical research conducted with the aid of iron 59. V. The metabolism of iron in patients with iron-protein-deficiency anemia]. 61
13841699 1959
12
[Analytic study of iron metabolism in normal and pathological conditions. Clinical research conducted with the aid of iron 59. IV. The metabolism of iron in patients with protein-deficiency anemia]. 61
13841698 1959
13
[Nature of blocking of maturation of erythrocytes responsible for protein-deficiency anemia and role of hormonal balance disorders in its formation]. 61
13307445 1955
14
[The aggravating effect of thyroidectomy on protein deficiency anemia in the rat; neutralization of this effect by injections of vitamin B12]. 61
12988414 1952
15
[Hematological sequels of gastrectomy; protein deficiency anemia in 110 cases of gastrectomy]. 61
13048572 1952
16
The protein deficiency anemia. 61
20268682 1946

Variations for Protein-Deficiency Anemia

Expression for Protein-Deficiency Anemia

Search GEO for disease gene expression data for Protein-Deficiency Anemia.

Pathways for Protein-Deficiency Anemia

Pathways related to Protein-Deficiency Anemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.05 INS GH2 GH1 F2
2
Show member pathways
12.86 INS GH2 GH1 F2
3
Show member pathways
12.38 INS GH2 GH1
4
Show member pathways
12.14 INS GH2 GH1 F2
5 11.55 INS GH1
6
Show member pathways
10.87 GH2 GH1
7 10.48 IGFBP1 F2
8 10.44 INS IGFBP1 F2

GO Terms for Protein-Deficiency Anemia

Cellular components related to Protein-Deficiency Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.55 INS IGFBP1 GH2 GH1 F2
2 endoplasmic reticulum lumen GO:0005788 9.43 INS IGFBP1 F2
3 extracellular space GO:0005615 9.35 INS IGFBP1 GH2 GH1 F2
4 Golgi lumen GO:0005796 9.32 INS F2
5 endosome lumen GO:0031904 8.8 INS GH2 GH1

Biological processes related to Protein-Deficiency Anemia according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.85 INS IGFBP1 GH2 GH1
2 cellular protein metabolic process GO:0044267 9.58 INS IGFBP1 F2
3 insulin receptor signaling pathway GO:0008286 9.54 INS IGFBP1
4 response to nutrient levels GO:0031667 9.52 GH2 GH1
5 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.51 GH2 GH1
6 acute-phase response GO:0006953 9.49 INS F2
7 positive regulation of protein localization to nucleus GO:1900182 9.48 INS F2
8 negative regulation of proteolysis GO:0045861 9.46 INS F2
9 animal organ development GO:0048513 9.43 GH2 GH1
10 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.37 GH2 GH1
11 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.33 INS GH1 F2
12 growth hormone receptor signaling pathway GO:0060396 9.32 GH2 GH1
13 positive regulation of growth GO:0045927 9.26 GH2 GH1
14 positive regulation of cell growth GO:0030307 9.13 INS IGFBP1 F2
15 positive regulation of JAK-STAT cascade GO:0046427 8.8 GH2 GH1 F2

Molecular functions related to Protein-Deficiency Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.33 GH2 GH1 F2
2 growth hormone receptor binding GO:0005131 8.96 GH2 GH1
3 hormone activity GO:0005179 8.8 INS GH2 GH1

Sources for Protein-Deficiency Anemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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