Protein-Energy Malnutrition disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

PEM MCID: PRT038 MIFTS: 53	Protein-Energy Malnutrition (PEM) Categories: Metabolic diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Protein-Energy Malnutrition

MalaCards integrated aliases for Protein-Energy Malnutrition:

Name: Protein-Energy Malnutrition ¹¹ ⁷⁵ ⁵³ ⁴³ ¹⁴ ⁷¹

Protein Energy Malnutrition ¹⁶

Pem ⁴⁷

Classifications:

MalaCards categories:
Global: Metabolic diseases

See all MalaCards categories (disease lists)

ICD10: ³¹

Endocrine, nutritional and metabolic diseases

Malnutrition

Unspecified protein-energy malnutrition

External Ids:

Disease Ontology ¹¹ DOID:11801

ICD9CM ³⁴ 263.9

MeSH ⁴³ D011502

NCIt ⁴⁹ C34952

SNOMED-CT ⁶⁸ 72608005

ICD10 ³¹ E46

EFO ¹⁶ EFO_0009563

UMLS ⁷¹ C0033677

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Summaries for Protein-Energy Malnutrition

Disease Ontology: ¹¹ A nutritional deficiency disease that is characterized by inadequate dietary protein and calories, which can have profound systemic effects including decreased metabolism, altered tissue distribution, compromised immunity, and impaired growth, and has material basis in dietary deprivation.

MalaCards based summary: Protein-Energy Malnutrition, also known as protein energy malnutrition, is related to marasmus and chronic fatigue syndrome, and has symptoms including cachexia and emaciation. An important gene associated with Protein-Energy Malnutrition is ALB (Albumin), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers and Mesenchymal Stem Cells and Lineage-specific Markers. The drugs Pentoxifylline and Antioxidants have been mentioned in the context of this disorder. Affiliated tissues include liver, skeletal muscle and thymus, and related phenotypes are homeostasis/metabolism and liver/biliary system

Wikipedia: ⁷⁵ Protein-energy malnutrition (PEM), sometimes called protein-energy undernutrition (PEU), is a form of... more...

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Related Diseases for Protein-Energy Malnutrition

Diseases related to Protein-Energy Malnutrition via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 638)

#	Related Disease	Score	Top Affiliating Genes
1	marasmus	32.1	TTR TF LEPQTL1 LEP IGF1 ALB
2	chronic fatigue syndrome	32.0	TNF IL6 IGF1
3	kwashiorkor	32.0	TTR SHBG LEP IGF1 GPT ALB
4	iron metabolism disease	31.0	TTR TF CP
5	gastroenteritis	30.7	TNF IL6 CP ALB
6	nutritional deficiency disease	30.6	TTR TF SI RBP4 MGAM LEPQTL1
7	protein-losing enteropathy	30.5	TTR GPT ALB
8	poliomyelitis	30.5	TNF IL6 ALB
9	plasmodium falciparum malaria	30.5	TNF IL6 HP
10	visceral leishmaniasis	30.5	TNF IL6 ALB
11	urinary tract infection	30.4	TNF IL6 GPT ALB
12	leishmaniasis	30.4	TNF IL6 GPT ALB
13	lactose intolerance	30.4	TNF SI IL6 ALB
14	insulin-like growth factor i	30.4	SHBG LEPQTL1 LEP IL6 IGF1
15	fetal macrosomia	30.4	LEPQTL1 LEP IGF1
16	goiter	30.4	SHBG IL6 IGF1
17	eating disorder	30.3	LEPQTL1 LEP IGF1
18	decubitus ulcer	30.3	TTR TNF IL6 IGF1 ALB
19	pyuria	30.3	IL6 GPT ALB
20	avian influenza	30.3	TNF IL6 ALB
21	plague	30.3	TNF IL6 ALB
22	miliary tuberculosis	30.3	TNF GPT ALB
23	viral hepatitis	30.3	MPO IL6 GPT ALB
24	parasitic helminthiasis infectious disease	30.2	TNF IL6 ALB
25	alcohol dependence	30.2	TNF TF LEP GPT CP ALB
26	anorexia nervosa	30.2	TTR SHBG LEPQTL1 LEP IGF1
27	viral pneumonia	30.2	TNF IL6 GPT
28	alcohol use disorder	30.2	TNF TF IL6 GPT ALB
29	adult syndrome	30.2	TNF LEP IL6 IGF1
30	uremia	30.2	TNF LEP IL6 ALB
31	pancreatitis	30.2	TNF IL6 CFTR ALB
32	tetanus	30.1	TNF IL6 IGF1 ALB
33	pulmonary disease, chronic obstructive	30.1	TNF MPO IL6 CFTR ALB
34	deficiency anemia	30.1	TTR TNF TF LEP IL6 IGF1
35	juvenile rheumatoid arthritis	30.1	TNF IL6 IL1RAPL2 HP
36	metabolic acidosis	30.1	IL6 IGF1 GPT ALB
37	peptic ulcer disease	30.1	TNF IL6 GPT ALB
38	meningitis	30.1	TNF MPO IL6 ALB
39	cholera	30.1	TNF TF IL6 CFTR
40	alcoholic liver cirrhosis	30.1	TNF IL6 GPT ALB
41	alcoholic hepatitis	30.1	TNF IL6 GPT ALB
42	iron deficiency anemia	30.0	TNF TF LTF IL6 CP
43	hyperinsulinism	30.0	SHBG LEPQTL1 LEP IGF1
44	pericardial effusion	30.0	TTR TNF IL6 GPT ALB
45	hepatic encephalopathy	30.0	TTR TNF IL6 GPT ALB
46	hypogonadotropic hypogonadism	29.9	SHBG LEP IGF1 CFTR
47	sickle cell anemia	29.9	TNF IL6 HP CFTR ALB
48	bronchiectasis	29.9	TNF MPO IL6 CFTR ALB
49	adult respiratory distress syndrome	29.9	TNF TF MPO IL6 CP
50	acute kidney failure	29.9	RBP4 IL6 HP GPT ALB

Comorbidity relations with Protein-Energy Malnutrition via Phenotypic Disease Network (PDN): (show top 50) (show all 149)

Acquired Thrombocytopenia	Active Peptic Ulcer Disease
Acute Conjunctivitis	Acute Cystitis
Acute Kidney Failure	Acute Myocardial Infarction
Acute Pancreatitis	Acute Vascular Insufficiency of Intestine
Alcohol Use Disorder	Alcoholic Hepatitis
Alcoholic Liver Cirrhosis	Alcoholic Neuropathy
Alzheimer Disease, Familial, 1	Anorexia Nervosa
Anxiety	Atrophic Gastritis
Bacteremia 2	Bronchiectasis
Bronchitis	Bronchopneumonia
Bullous Pemphigoid	Candidiasis
Cardiac Arrest	Cecal Benign Neoplasm
Celiac Disease 1	Cerebral Atherosclerosis
Cerebral Degeneration	Cerebrovascular Disease
Cholangitis	Cholecystitis
Cholestasis	Chronic Intestinal Vascular Insufficiency
Chronic Kidney Disease	Chronic Pulmonary Heart Disease
Chronic Ulcer of Skin	Chylomicron Retention Disease
Colorectal Cancer	Conjunctivitis
Crohn's Disease	Cystitis
Decubitus Ulcer	Deficiency Anemia
Dental Caries	Dermatomycosis
Disseminated Intravascular Coagulation	Duodenum Cancer
Dyskinesia of Esophagus	Dysthymic Disorder
Encephalopathy	Enterovesical Fistula

Graphical network of the top 20 diseases related to Protein-Energy Malnutrition:

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Symptoms & Phenotypes for Protein-Energy Malnutrition

UMLS symptoms related to Protein-Energy Malnutrition:

cachexia; emaciation

MGI Mouse Phenotypes related to Protein-Energy Malnutrition:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.2	ALB CFTR CP HP IGF1 IL6
2	liver/biliary system	MP:0005370	9.97	ALB CFTR CP HP IL6 LEP
3	neoplasm	MP:0002006	9.95	ALB HP IGF1 IL6 LEP LTF
4	cardiovascular system	MP:0005385	9.9	ALB CP HP IGF1 IL6 LEP
5	digestive/alimentary	MP:0005381	9.86	ALB CFTR IL6 LEP PIGR RBP4
6	immune system	MP:0005387	9.73	ALB CFTR CP HP IGF1 IL6
7	hematopoietic system	MP:0005397	9.4	CFTR CP HP IGF1 IL6 LEP

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Drugs & Therapeutics for Protein-Energy Malnutrition

Drugs for Protein-Energy Malnutrition (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 82)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Pentoxifylline

Approved, Investigational

Phase 3

6493-05-6

4740

Antioxidants

Phase 3

Radiation-Protective Agents

Phase 3

Phosphodiesterase Inhibitors

Phase 3

Vasodilator Agents

Phase 3

Platelet Aggregation Inhibitors

Phase 3

Anti-Inflammatory Agents

Phase 3

Protective Agents

Phase 3

Ferrous fumarate

Approved

141-01-5

Iron

Approved

7439-89-6

29936

Nicotinamide

Approved, Investigational

98-92-0

936

Iodine

Approved, Investigational

7553-56-2

807

Copper

Approved, Investigational

7440-50-8

27099

Mecobalamin

Approved, Investigational

13422-55-4

Hydroxocobalamin

Approved

13422-51-0

15589840 44475014

Amoxicillin

Approved, Vet_approved

26787-78-0

33613

Cefdinir

Approved

91832-40-5

6915944

Strawberry

Approved

Lamivudine

Approved, Investigational

134678-17-4

60825

Nevirapine

Approved

129618-40-2

4463

Zidovudine

Approved

30516-87-1

35370

Levoleucovorin

Approved, Experimental, Investigational

68538-85-2, 58-05-9, 73951-54-9

149436 6006

Miconazole

Approved, Investigational, Vet_approved

22916-47-8

4189

Clotrimazole

Approved, Vet_approved

23593-75-1

2812

Cianidanol

Approved, Withdrawn

154-23-4

9064

Phenol

Approved, Experimental

108-95-2

996

Benzocaine

Approved, Investigational

1994-09-7, 94-09-7

2337

Tannic acid

Approved

1401-55-4

16129878 16129778

Tocopherol

Approved, Investigational

1406-66-2

Cholecalciferol

Approved, Nutraceutical, Vet_approved

67-97-0, 1406-16-2

5280795 10883523

Ascorbic acid

Approved, Nutraceutical

50-81-7

54676860 54670067 5785

Niacin

Approved, Investigational, Nutraceutical

59-67-6

938

Pyridoxine

Approved, Investigational, Nutraceutical, Vet_approved

65-23-6

1054

Cyanocobalamin

Approved, Nutraceutical

68-19-9

24892734 16212801 44176380

Thiamine

Approved, Investigational, Nutraceutical, Vet_approved

70-16-6

1130

Riboflavin

Approved, Investigational, Nutraceutical, Vet_approved

83-88-5

493570

D-Phenylalanine

Approved, Experimental, Investigational, Nutraceutical

63-91-2, 673-06-3

6140 71567

Cysteine

Approved, Nutraceutical

52-90-4

594 5862

Folic acid

Approved, Nutraceutical, Vet_approved

59-30-3

6037

Vitamin A

Approved, Nutraceutical, Vet_approved

22737-96-8, 68-26-8

5280382 445354

DL-alpha-Tocopherol

Approved, Experimental, Investigational, Nutraceutical, Vet_approved

59-02-9, 10191-41-0

2116 14985

Cadexomer iodine

Experimental

94820-09-4

Cobalamin

Experimental

13408-78-1

6857388

Epicatechin

Investigational

490-46-0

58571364 72276

Tocotrienol

Investigational

6829-55-6

9929901

Disinfectants

Vitamin B6

Vitamin B3

Calciferol

Nicotinic Acids

Interventional clinical trials:

(show all 27)

#	Name	Status	NCT ID	Phase	Drugs
1	Randomized, Open Label, Controlled Clinical Trial of Egg Albumin-Based Protein Supplement Versus Renal Specific Oral Supplement in Hemodialysis Patients	Unknown status	NCT01981083	Phase 4
2	Pilot/Feasibility Randomized Control Trial to Examine the Effect of Oral Nutritional Supplements With Anti-inflammatory/Anti-oxidative Properties and Pentoxiphylline on Malnutrition-inflammation-cachexia Syndrome in Maintenance Hemodialysis Patients	Completed	NCT00561093	Phase 3	pentoxiphylline;Placebo pill imitating pentoxiphylline
3	A Randomized, Double-blind, Placebo-controlled, Parallel-group, Pilot Study to Investigate the Safety and Efficacy of Cannabis Oil in Maintenance Hemodialysis Patients With Protein-energy Wasting	Withdrawn	NCT03664141	Phase 3	Cannabis oil;Placebo/ Regular Oil
4	Effectiveness of Safe Drinking Water in Community Based Treatment of Severe Acute Malnutrition	Unknown status	NCT02751476
5	NutFish and Nutrient Supplementation in Pregnancy Class to Improve Maternal and Birth Outcomes	Unknown status	NCT02959125
6	Effect of the Administration of an Enteral Milk Supplemented With Proteins to Infants Admitted in a Pediatric Intensive Care Unit	Unknown status	NCT03901742
7	Feeding Behavior and Taste Sensitivity Before and After Liver or Renal Transplantation	Unknown status	NCT02931812
8	The (Cost) Effectiveness of Increasing Daily Protein Intake to 1.2 Gram Per Kilo Body Weight on Physical Functioning in Community-dwelling Older Adults With a Habitual Daily Protein Intake < 1.0 Gram Per Kilo Body Weight	Completed	NCT03712306
9	Bioavailability of Essential Amino Acids From the Common Bean (Phaseolus Vulgaris) in Young Healthy Jamaican Adults Consuming a Typical Meal	Completed	NCT04118517
10	A Randomized, Double-blind Pilot Study of Polyunsaturated Fatty Acid-optimized Ready-to-use Therapeutic Food, Compared to Standard RUTF, in the Therapy of Severe Acute Malnutrition	Completed	NCT02053857		Amoxicillin
11	Randomized, Double-blind, Placebo-controlled Trial to Evaluate the Effectiveness of Oral Antibiotics in the Community-based Treatment of Severe Acute Malnutrition in Malawian Children	Completed	NCT01000298		Placebo;Amoxicillin;Cefdinir
12	Patient Safety Learning Laboratory: Improving Safety of Diagnosis and Therapy in the Inpatient Setting	Completed	NCT04393909
13	Characterizing the Gut Microbiota Alteration Associated With Severe Acute Malnutrition	Completed	NCT02413905
14	Glutathione Homeostasis and Oxidant Damage in Kwashiorkor	Completed	NCT00069134
15	Evaluation of the Effectiveness of a Protein Pulse-Feeding Pattern in Elderly Patients	Completed	NCT00135590
16	Intervention Study for Validation of Application of a Prediction Model in Maintenance Hemodialysis Patients	Completed	NCT03642678
17	Distribution of an Energy Rich Formula at Medication Rounds to Individuals Living in Old Peoples Home - Effects on Energy Intake Compared to Standard Nutritional Treatment	Completed	NCT01259999
18	Mothers Understand And Can do it - Mid Upper Arm Circumference Screening for Malnutrition Performed by Mothers of Children < 5 Years Old	Completed	NCT01790815
19	ART Pharmacokinetics, Mitochondrial Integrity, and Antioxidant Capacity in Severely Malnourished HIV-infected Malawian Children	Completed	NCT01529125		zidovudine, lamivudine, nevirapine
20	Effects of Varying Energy Deficits on Protein Turnover at Rest and Carbohydrate Oxidation During Steady-state Exercise	Recruiting	NCT04910724
21	The Impact of Energy Intake and Short-term Disuse on Muscle Protein Synthesis Rates and Skeletal Muscle Mass in Middle-aged Adults.	Recruiting	NCT04900701
22	The Underlying Causes Affecting the Response to Dietary Rehabilitation in Severely Acutely Malnourished Children at the Center Hôspitalier Universitaire Sourô Sanou, Bobo Dioulasso, Burkina Faso	Recruiting	NCT05009823
23	The Underlying Causes Affecting the Response to Dietary Rehabilitation in Severely Acutely Malnourished Children at the Center Hôspitalier Universitaire Sourô Sanou, Bobo Dioulasso, Burkina Faso	Recruiting	NCT05020847
24	Combining Vitamin E-functionalized CHOcolate With Physical Exercise to Reduce the risK Of Protein Energy Malnutrition in Pre-dementia AGEd People	Recruiting	NCT05343611
25	Evaluation of Protein Bioavailability, Satiety and Appetite Responses to Protein Fortified Porridge in Older Adults	Not yet recruiting	NCT05512975
26	Assess Effect of Oral Nutritional Supplementation on Oxidative Stress Levels in Protein-energy Wasting Patients With Continuous Ambulatory Peritoneal Dialysis	Not yet recruiting	NCT04628117
27	Randomized, Double-blind, Placebo-controlled Trial to Evaluate the Benefit of Antihelminthic Therapy in the Community-Based Treatment of Severe Acute Malnutrition in Malawian Children	Withdrawn	NCT01395381		Placebo;Albendazole

Search NIH Clinical Center for Protein-Energy Malnutrition

Cochrane evidence based reviews: protein-energy malnutrition

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Genetic Tests for Protein-Energy Malnutrition

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Anatomical Context for Protein-Energy Malnutrition

Organs/tissues related to Protein-Energy Malnutrition:

MalaCards : Liver, Skeletal Muscle, Thymus, Kidney, Bone Marrow, Small Intestine, Brain

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Publications for Protein-Energy Malnutrition

Articles related to Protein-Energy Malnutrition:

(show top 50) (show all 2248)

#	Title	Authors	PMID	Year
1	Serum albumin and total lymphocyte count as predictors of outcome in hip fractures. ⁵³ ⁶²	O'Daly BJ...O'Rourke SK	19674819	2010
2	The evolution of nutritional status of geriatric patients without cachexia is associated with food intake in sub-acute care. ⁵³ ⁶²	St-Arnaud McKenzie D...Ferland G	19214334	2009
3	Mini Nutritional Assessment (short form) and functional decline in older patients admitted to an acute medical ward. ⁵³ ⁶²	Salvi F...Dessi-Fulgheri P	18852545	2008
4	Growth hormone treatment during hemodialysis in a randomized trial improves nutrition, quality of life, and cardiovascular risk. ⁵³ ⁶²	Feldt-Rasmussen B...APCD Study Group	17554147	2007
5	Are insulin-like growth factor and its binding proteins 1 and 3 clinically useful as markers of malnutrition, sarcopenia and inflammation in end-stage renal disease? ⁵³ ⁶²	Axelsson J...Stenvinkel P	16391585	2006
6	Nutritional status of patients hospitalised in Poland. ⁵³ ⁶²	Dzieniszewski J...Orzeszko M	15714213	2005
7	Early detection of protein energy malnutrition in Sharkia Governorate. ⁵³ ⁶²	Shaaban SY...Mohamed I	17187748	2005
8	Serum total protein, albumin and A/G ratio in different grades of protein energy malnutrition. ⁵³ ⁶²	Rahman MZ...Begum BA	15695952	2005
9	Serum leptin concentrations in children with mild protein-energy malnutrition and catch-up growth. ⁵³ ⁶²	Buyukgebiz B...Arslan N	15491379	2004
10	Serum leptin concentrations in children with mild-to-moderate protein-energy malnutrition. ⁵³ ⁶²	Buyukgebiz B...Arslan N	14521530	2003
11	[Nutritional status of patients in hospitals in Poland. I. Screening of adult patients]. ⁵³ ⁶²	Dzieniszewski J...Ryzko-Skiba M	14648979	2003
12	Observations with regard to the National Kidney Foundation K/DOQI clinical practice guidelines concerning serum transthyretin in chronic renal failure. ⁵³ ⁶²	Kopple JD...Kalantar-Zadeh K	12553435	2002
13	Affect of serum leptin on nutritional status in renal disease. ⁵³ ⁶²	Norton PA	12171457	2002
14	Leptin levels and IgF-binding proteins in malnourished children: effect of weight gain. ⁵³ ⁶²	Palacio AC...Monckeberg F	11827758	2002
15	[Effects of vitamin A supplementation on nutritional markers on the follow-up of malnutrition in children]. ⁵³ ⁶²	Ake M...Monnet D	11470636	2001
16	Use and abuse of albumin: a survey of clinical records from an internal medicine ward. ⁵³ ⁶²	Finelli C...Contaldo F	11327749	2001
17	Nutritional management of maintenance dialysis patients: why aren't we doing better? ⁵³ ⁶²	Mehrotra R...Kopple JD	11375441	2001
18	Serum leptin concentrations during severe protein-energy malnutrition: correlation with growth parameters and endocrine function. ⁵³ ⁶²	Soliman AT...Ansari BM	10909989	2000
19	Relationship between plasma retinol and infectious diseases in the elderly. A case-control study. ⁵³ ⁶²	Chau N...Debry G	11146333	2000
20	The relationship between plasma leptin and nutritional status in chronic hemodialysis patients. ⁵³ ⁶²	Koo JR...Noh JW	10576151	1999
21	Low levels of plasma proteins: malnutrition or inflammation? ⁵³ ⁶²	Johnson AM	10219494	1999
22	Study of plasma albumin, transferrin, and fibronectin in children with mild to moderate protein-energy malnutrition. ⁵³ ⁶²	Hassanein el-S A...el-Maghraby RM	9972082	1998
23	Depression in the quantity of intestinal secretory IgA and in the expression of the polymeric immunoglobulin receptor in caloric deficiency of the weanling mouse. ⁵³ ⁶²	Ha CL...Woodward B	9800951	1998
24	Arginine increases insulin-like growth factor-I production and collagen synthesis in osteoblast-like cells. ⁵³ ⁶²	Chevalley T...Bonjour JP	9701468	1998
25	Repletion of the plasma pool of nutrient transport proteins occurs at different rates during the nutritional rehabilitation of severely malnourished children. ⁵³ ⁶²	Morlese JF...Jahoor F	9446846	1998
26	Increased plasma leptin/fat ratio in patients with chronic renal failure: a cause of malnutrition? ⁵³ ⁶²	Young GA...Smith MA	9394318	1997
27	Transferrin kinetics are altered in children with severe protein-energy malnutrition. ⁵³ ⁶²	Morlese JF...Jahoor F	9237939	1997
28	Nutritional status as a predictor of morbidity and mortality in maintenance dialysis patients. ⁵³ ⁶²	Kopple JD	9152503	1997
29	Enhanced generation of interleukins 1 beta and 6 may contribute to the cachexia of chronic disease. ⁵³ ⁶²	Cederholm T...Palmblad J	9062543	1997
30	Reduction in the quantity of the polymeric immunoglobulin receptor is sufficient to account for the low concentration of intestinal secretory immunoglobulin A in a weanling mouse model of wasting protein-energy malnutrition. ⁵³ ⁶²	Ha CL...Woodward B	9082026	1997
31	Assessment of plasma fibronectin in malnourished Nigerian children. ⁵³ ⁶²	Akenami FO...Vaheri A	9106105	1997
32	Albumin kinetics in edematous and nonedematous protein-energy malnourished children. ⁵³ ⁶²	Morlese JF...Jahoor F	8942422	1996
33	Growth hormone-binding proteins and insulin-like growth factor-binding proteins in protein-energy malnutrition, before and after nutritional rehabilitation. ⁵³ ⁶²	Zamboni G...Tato L	8929859	1996
34	Radiological, biochemical, and hormonal changes in malnourished children with rachitic manifestations. ⁵³ ⁶²	Soliman AT...Morsi MR	8820618	1996
35	Plasma free carnitine levels in children with malnutrition. ⁵³ ⁶²	Tanzer F...Atalay A	8016914	1994
36	Postprandial cholecystokinin secretion in elderly with protein-energy undernutrition. ⁵³ ⁶²	Berthelemy P...Ribet A	1372922	1992
37	Can total parenteral nutrition reverse hypoalbuminemia in oncology patients? ⁵³ ⁶²	Gray GE...Meguid MM	2136002	1990
38	Biochemical profile of heifers with spontaneous humeral fractures suggest that protein-energy malnutrition could be an important factor in the pathology of this disease. ⁶²	Wehrle-Martinez A...Lawrence K	36210546	2023
39	Genome Editing and Protein Energy Malnutrition. ⁶²	Moreno-Nombela S...Plaza-Diaz J	36454470	2023
40	Quantitative histologic evaluation reveals different degree of liver atrophy in cachectic and starved dogs. ⁶²	Ricci E...Ressel L	36184936	2022
41	Association of Subjective Global Assessment with outcomes in the intensive care unit: A retrospective cohort study. ⁶²	Ferrie S...Stepniewski ME	36127861	2022
42	Pathogenesis of Severe Liver Injury in Patients with Anorexia Nervosa: A Report of Two Cases and a Literature Review. ⁶²	Sakata M...Okada H	36130885	2022
43	Healthy aging and chronic kidney disease. ⁶²	Merchant RA...Vathsala A	36328991	2022
44	Impact of malnutrition management E-Learning module on general practitioners' Knowledge. ⁶²	Geraghty AA...Corish C	36410769	2022
45	Effects of blending ratios and baking temperature on physicochemical properties and sensory acceptability of biscuits prepared from pumpkin, common bean, and wheat composite flour. ⁶²	Melese AD...Keyata EO	36247146	2022
46	Protein Intake and Oral Health in Older Adults-A Narrative Review. ⁶²	Jayasinghe TN...Eberhard J	36364741	2022
47	Eye movement impairments in children with malnutrition. ⁶²	Almeida NL...Santos NA	35262928	2022
48	Clinical Profile and Immediate Outcome of Pyogenic Meningitis in Children. ⁶²	Mazumder S...Saha BK	36189547	2022
49	Protein-energy malnutrition worsens hospitalization outcomes of patients with pancreatic cancer undergoing open pancreaticoduodenectomy. ⁶²	Zhang YX...Kong H	35524935	2022
50	Fluid Overload and Tissue Sodium Accumulation as Main Drivers of Protein Energy Malnutrition in Dialysis Patients. ⁶²	Canaud B...Cristol JP	36364751	2022

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Genes for Protein-Energy Malnutrition

Genes related to Protein-Energy Malnutrition (0 elite genes):

(show all 21)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	ALB	Albumin	Protein Coding	27.11	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	10219494 15695952 9106105 (more) 10433138 19674819 11847733 8942422 11146333 9892378 14648979 9152503 2136002 19214334 17554147 10909989 15539240 15714213 8016914 1843944 11327749 18852545 11295031 17187748 7564120
2	TTR	Transthyretin	Protein Coding	26.58	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	9611291 10340103 12553435 (more) 10433138 10219494 9446846 11146333 1898583 11470636
3	IGF1	Insulin Like Growth Factor 1	Protein Coding	20.89	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	16391585 8928772 9046366 (more) 8820618 8929859 10909989 11827758 12223429 9701468
4	TF	Transferrin	Protein Coding	20.22	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	9106105 9972082 10219494 (more) 11146333 1909193 9237939 9394318
5	LEP	Leptin	Protein Coding	20.12	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	18605195 11053487 11375441 (more) 12171457 10909989 11827758 10576151
6	PIGR	Polymeric Immunoglobulin Receptor	Protein Coding	16.52	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	9082026 9800951
7	LEPQTL1	Leptin, Serum Levels Of	Genetic Locus	14.24	Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	14521530 15491379 11045179 (more) 10909989 12171457
8	IL6	Interleukin 6	Protein Coding	14.18	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
9	TNF	Tumor Necrosis Factor	Protein Coding	13.62	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
10	GPT	Glutamic--Pyruvic Transaminase	Protein Coding	13.2	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
11	CP	Ceruloplasmin	Protein Coding	12.98	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
12	HP	Haptoglobin	Protein Coding	12.71	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
13	CFTR	CF Transmembrane Conductance Regulator	Protein Coding	12.03	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
14	MPO	Myeloperoxidase	Protein Coding	11.77	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
15	SHBG	Sex Hormone Binding Globulin	Protein Coding	11.21	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
16	RBP4	Retinol Binding Protein 4	Protein Coding	11.04	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	11470636
17	SI	Sucrase-Isomaltase	Protein Coding	11	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
18	MGAM	Maltase-Glucoamylase	Protein Coding	10.97	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
19	LTF	Lactotransferrin	Protein Coding	10.52	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
20	IL1RAPL2	Interleukin 1 Receptor Accessory Protein Like 2	Protein Coding	9.95	Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	9062543
21	CCK	Cholecystokinin	Protein Coding	8.96	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	1372922

Sources

Variations for Protein-Energy Malnutrition

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Expression for Protein-Energy Malnutrition

Search GEO for disease gene expression data for Protein-Energy Malnutrition.

Sources

Pathways for Protein-Energy Malnutrition

Pathways related to Protein-Energy Malnutrition according to GeneCards Suite gene sharing:

(show all 12)

#	Super pathways	Score	Top Affiliating Genes
1	Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers ⁶⁵	11.68	IL6 IGF1 CFTR ALB
2	Mesenchymal Stem Cells and Lineage-specific Markers ⁶⁵	11.66	LEP IL6 IGF1
3	Clock-controlled autophagy in bone metabolism ⁷⁴	11.57	LEP IL6 IGF1
4	Adipogenesis ⁷⁴	11.57	TNF LEP IL6 IGF1
5	HIF-1-alpha transcription factor network ⁶¹	11.47	TF LEP CP
6	Lung fibrosis ⁷⁴	11.43	TNF IL6 IGF1
7	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) ⁶⁶ Show member pathways Post-translational protein phosphorylation ⁶⁶	11.39	TF IL6 IGF1 CP ALB
8	Pluripotent stem cell differentiation pathway ⁷⁴	11.26	TF IL6 IGF1
9	Nonalcoholic fatty liver disease ⁷⁴	11.21	TNF LEP IL6
10	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²²	11.15	TNF IL6 IGF1
11	Transcription factor regulation in adipogenesis ⁷⁴	10.47	TNF LEP IL6
12	Cells and molecules involved in local acute inflammatory response ⁷⁴ Show member pathways IL8-mediated signaling events ⁶¹	10.13	TNF IL6

Sources

GO Terms for Protein-Energy Malnutrition

Cellular components related to Protein-Energy Malnutrition according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular exosome	GO:0070062	10.27	ALB CP GPT HP LTF MGAM
2	extracellular region	GO:0005576	10.09	ALB CP HP IGF1 IL6 LEP
3	blood microparticle	GO:0072562	9.97	TF HP CP ALB
4	recycling endosome	GO:0055037	9.92	TNF TF LTF CFTR
5	extracellular space	GO:0005615	9.75	ALB CP GPT HP IGF1 IL6
6	phagocytic vesicle lumen	GO:0097013	9.56	MPO LTF

Biological processes related to Protein-Energy Malnutrition according to GeneCards Suite gene sharing:

(show all 11)

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of apoptotic process	GO:0043066	10.07	TNF MPO LTF LEP IL6 IGF1
2	regulation of insulin secretion	GO:0050796	9.97	TNF LEP IL6
3	response to activity	GO:0014823	9.95	TNF LEP IL6
4	iron ion homeostasis	GO:0055072	9.91	TF LTF CP
5	positive regulation of receptor signaling pathway via JAK-STAT	GO:0046427	9.88	TNF LEP IL6
6	iron ion transport	GO:0006826	9.8	CP LTF TF
7	bone mineralization involved in bone maturation	GO:0035630	9.76	LEP IGF1
8	positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	9.76	TNF LEP IL6 IGF1
9	response to gold nanoparticle	GO:1990268	9.67	TNF MPO
10	negative regulation of lipid storage	GO:0010888	9.43	TNF LEP IL6
11	retina homeostasis	GO:0001895	9.23	TF PIGR LTF ALB