PEM
MCID: PRT038
MIFTS: 53

Protein-Energy Malnutrition (PEM)

Categories: Metabolic diseases
Data Licensing
For inquiries, contact:

Aliases & Classifications for Protein-Energy Malnutrition

MalaCards integrated aliases for Protein-Energy Malnutrition:

Name: Protein-Energy Malnutrition 11 75 53 43 14 71
Protein Energy Malnutrition 16
Pem 47

Classifications:



External Ids:

Disease Ontology 11 DOID:11801
ICD9CM 34 263.9
MeSH 43 D011502
NCIt 49 C34952
SNOMED-CT 68 72608005
ICD10 31 E46
UMLS 71 C0033677

Summaries for Protein-Energy Malnutrition

Disease Ontology: 11 A nutritional deficiency disease that is characterized by inadequate dietary protein and calories, which can have profound systemic effects including decreased metabolism, altered tissue distribution, compromised immunity, and impaired growth, and has material basis in dietary deprivation.

MalaCards based summary: Protein-Energy Malnutrition, also known as protein energy malnutrition, is related to marasmus and chronic fatigue syndrome, and has symptoms including cachexia and emaciation. An important gene associated with Protein-Energy Malnutrition is ALB (Albumin), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers and Mesenchymal Stem Cells and Lineage-specific Markers. The drugs Pentoxifylline and Antioxidants have been mentioned in the context of this disorder. Affiliated tissues include liver, skeletal muscle and thymus, and related phenotypes are homeostasis/metabolism and liver/biliary system

Wikipedia: 75 Protein-energy malnutrition (PEM), sometimes called protein-energy undernutrition (PEU), is a form of... more...

Related Diseases for Protein-Energy Malnutrition

Diseases related to Protein-Energy Malnutrition via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 638)
# Related Disease Score Top Affiliating Genes
1 marasmus 32.1 TTR TF LEPQTL1 LEP IGF1 ALB
2 chronic fatigue syndrome 32.0 TNF IL6 IGF1
3 kwashiorkor 32.0 TTR SHBG LEP IGF1 GPT ALB
4 iron metabolism disease 31.0 TTR TF CP
5 gastroenteritis 30.7 TNF IL6 CP ALB
6 nutritional deficiency disease 30.6 TTR TF SI RBP4 MGAM LEPQTL1
7 protein-losing enteropathy 30.5 TTR GPT ALB
8 poliomyelitis 30.5 TNF IL6 ALB
9 plasmodium falciparum malaria 30.5 TNF IL6 HP
10 visceral leishmaniasis 30.5 TNF IL6 ALB
11 urinary tract infection 30.4 TNF IL6 GPT ALB
12 leishmaniasis 30.4 TNF IL6 GPT ALB
13 lactose intolerance 30.4 TNF SI IL6 ALB
14 insulin-like growth factor i 30.4 SHBG LEPQTL1 LEP IL6 IGF1
15 fetal macrosomia 30.4 LEPQTL1 LEP IGF1
16 goiter 30.4 SHBG IL6 IGF1
17 eating disorder 30.3 LEPQTL1 LEP IGF1
18 decubitus ulcer 30.3 TTR TNF IL6 IGF1 ALB
19 pyuria 30.3 IL6 GPT ALB
20 avian influenza 30.3 TNF IL6 ALB
21 plague 30.3 TNF IL6 ALB
22 miliary tuberculosis 30.3 TNF GPT ALB
23 viral hepatitis 30.3 MPO IL6 GPT ALB
24 parasitic helminthiasis infectious disease 30.2 TNF IL6 ALB
25 alcohol dependence 30.2 TNF TF LEP GPT CP ALB
26 anorexia nervosa 30.2 TTR SHBG LEPQTL1 LEP IGF1
27 viral pneumonia 30.2 TNF IL6 GPT
28 alcohol use disorder 30.2 TNF TF IL6 GPT ALB
29 adult syndrome 30.2 TNF LEP IL6 IGF1
30 uremia 30.2 TNF LEP IL6 ALB
31 pancreatitis 30.2 TNF IL6 CFTR ALB
32 tetanus 30.1 TNF IL6 IGF1 ALB
33 pulmonary disease, chronic obstructive 30.1 TNF MPO IL6 CFTR ALB
34 deficiency anemia 30.1 TTR TNF TF LEP IL6 IGF1
35 juvenile rheumatoid arthritis 30.1 TNF IL6 IL1RAPL2 HP
36 metabolic acidosis 30.1 IL6 IGF1 GPT ALB
37 peptic ulcer disease 30.1 TNF IL6 GPT ALB
38 meningitis 30.1 TNF MPO IL6 ALB
39 cholera 30.1 TNF TF IL6 CFTR
40 alcoholic liver cirrhosis 30.1 TNF IL6 GPT ALB
41 alcoholic hepatitis 30.1 TNF IL6 GPT ALB
42 iron deficiency anemia 30.0 TNF TF LTF IL6 CP
43 hyperinsulinism 30.0 SHBG LEPQTL1 LEP IGF1
44 pericardial effusion 30.0 TTR TNF IL6 GPT ALB
45 hepatic encephalopathy 30.0 TTR TNF IL6 GPT ALB
46 hypogonadotropic hypogonadism 29.9 SHBG LEP IGF1 CFTR
47 sickle cell anemia 29.9 TNF IL6 HP CFTR ALB
48 bronchiectasis 29.9 TNF MPO IL6 CFTR ALB
49 adult respiratory distress syndrome 29.9 TNF TF MPO IL6 CP
50 acute kidney failure 29.9 RBP4 IL6 HP GPT ALB

Comorbidity relations with Protein-Energy Malnutrition via Phenotypic Disease Network (PDN): (show top 50) (show all 149)


Acquired Thrombocytopenia Active Peptic Ulcer Disease
Acute Conjunctivitis Acute Cystitis
Acute Kidney Failure Acute Myocardial Infarction
Acute Pancreatitis Acute Vascular Insufficiency of Intestine
Alcohol Use Disorder Alcoholic Hepatitis
Alcoholic Liver Cirrhosis Alcoholic Neuropathy
Alzheimer Disease, Familial, 1 Anorexia Nervosa
Anxiety Atrophic Gastritis
Bacteremia 2 Bronchiectasis
Bronchitis Bronchopneumonia
Bullous Pemphigoid Candidiasis
Cardiac Arrest Cecal Benign Neoplasm
Celiac Disease 1 Cerebral Atherosclerosis
Cerebral Degeneration Cerebrovascular Disease
Cholangitis Cholecystitis
Cholestasis Chronic Intestinal Vascular Insufficiency
Chronic Kidney Disease Chronic Pulmonary Heart Disease
Chronic Ulcer of Skin Chylomicron Retention Disease
Colorectal Cancer Conjunctivitis
Crohn's Disease Cystitis
Decubitus Ulcer Deficiency Anemia
Dental Caries Dermatomycosis
Disseminated Intravascular Coagulation Duodenum Cancer
Dyskinesia of Esophagus Dysthymic Disorder
Encephalopathy Enterovesical Fistula

Graphical network of the top 20 diseases related to Protein-Energy Malnutrition:



Diseases related to Protein-Energy Malnutrition

Symptoms & Phenotypes for Protein-Energy Malnutrition

UMLS symptoms related to Protein-Energy Malnutrition:


cachexia; emaciation

MGI Mouse Phenotypes related to Protein-Energy Malnutrition:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.2 ALB CFTR CP HP IGF1 IL6
2 liver/biliary system MP:0005370 9.97 ALB CFTR CP HP IL6 LEP
3 neoplasm MP:0002006 9.95 ALB HP IGF1 IL6 LEP LTF
4 cardiovascular system MP:0005385 9.9 ALB CP HP IGF1 IL6 LEP
5 digestive/alimentary MP:0005381 9.86 ALB CFTR IL6 LEP PIGR RBP4
6 immune system MP:0005387 9.73 ALB CFTR CP HP IGF1 IL6
7 hematopoietic system MP:0005397 9.4 CFTR CP HP IGF1 IL6 LEP

Drugs & Therapeutics for Protein-Energy Malnutrition

Drugs for Protein-Energy Malnutrition (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 82)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pentoxifylline Approved, Investigational Phase 3 6493-05-6 4740
2 Antioxidants Phase 3
3 Radiation-Protective Agents Phase 3
4 Phosphodiesterase Inhibitors Phase 3
5 Vasodilator Agents Phase 3
6 Platelet Aggregation Inhibitors Phase 3
7 Anti-Inflammatory Agents Phase 3
8 Protective Agents Phase 3
9
Ferrous fumarate Approved 141-01-5
10
Iron Approved 7439-89-6 29936
11
Nicotinamide Approved, Investigational 98-92-0 936
12
Iodine Approved, Investigational 7553-56-2 807
13
Copper Approved, Investigational 7440-50-8 27099
14
Mecobalamin Approved, Investigational 13422-55-4
15
Hydroxocobalamin Approved 13422-51-0 15589840 44475014
16
Amoxicillin Approved, Vet_approved 26787-78-0 33613
17
Cefdinir Approved 91832-40-5 6915944
18 Strawberry Approved
19
Lamivudine Approved, Investigational 134678-17-4 60825
20
Nevirapine Approved 129618-40-2 4463
21
Zidovudine Approved 30516-87-1 35370
22
Levoleucovorin Approved, Experimental, Investigational 68538-85-2, 58-05-9, 73951-54-9 149436 6006
23
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
24
Clotrimazole Approved, Vet_approved 23593-75-1 2812
25
Cianidanol Approved, Withdrawn 154-23-4 9064
26
Phenol Approved, Experimental 108-95-2 996
27
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
28
Tannic acid Approved 1401-55-4 16129878 16129778
29
Tocopherol Approved, Investigational 1406-66-2
30
Cholecalciferol Approved, Nutraceutical, Vet_approved 67-97-0, 1406-16-2 5280795 10883523
31
Ascorbic acid Approved, Nutraceutical 50-81-7 54676860 54670067 5785
32
Niacin Approved, Investigational, Nutraceutical 59-67-6 938
33
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved 65-23-6 1054
34
Cyanocobalamin Approved, Nutraceutical 68-19-9 24892734 16212801 44176380
35
Thiamine Approved, Investigational, Nutraceutical, Vet_approved 70-16-6 1130
36
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved 83-88-5 493570
37
D-Phenylalanine Approved, Experimental, Investigational, Nutraceutical 63-91-2, 673-06-3 6140 71567
38
Cysteine Approved, Nutraceutical 52-90-4 594 5862
39
Folic acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
40
Vitamin A Approved, Nutraceutical, Vet_approved 22737-96-8, 68-26-8 5280382 445354
41
DL-alpha-Tocopherol Approved, Experimental, Investigational, Nutraceutical, Vet_approved 59-02-9, 10191-41-0 2116 14985
42
Cadexomer iodine Experimental 94820-09-4
43
Cobalamin Experimental 13408-78-1 6857388
44
Epicatechin Investigational 490-46-0 58571364 72276
45
Tocotrienol Investigational 6829-55-6 9929901
46 Disinfectants
47 Vitamin B6
48 Vitamin B3
49 Calciferol
50 Nicotinic Acids

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 Randomized, Open Label, Controlled Clinical Trial of Egg Albumin-Based Protein Supplement Versus Renal Specific Oral Supplement in Hemodialysis Patients Unknown status NCT01981083 Phase 4
2 Pilot/Feasibility Randomized Control Trial to Examine the Effect of Oral Nutritional Supplements With Anti-inflammatory/Anti-oxidative Properties and Pentoxiphylline on Malnutrition-inflammation-cachexia Syndrome in Maintenance Hemodialysis Patients Completed NCT00561093 Phase 3 pentoxiphylline;Placebo pill imitating pentoxiphylline
3 A Randomized, Double-blind, Placebo-controlled, Parallel-group, Pilot Study to Investigate the Safety and Efficacy of Cannabis Oil in Maintenance Hemodialysis Patients With Protein-energy Wasting Withdrawn NCT03664141 Phase 3 Cannabis oil;Placebo/ Regular Oil
4 Effectiveness of Safe Drinking Water in Community Based Treatment of Severe Acute Malnutrition Unknown status NCT02751476
5 NutFish and Nutrient Supplementation in Pregnancy Class to Improve Maternal and Birth Outcomes Unknown status NCT02959125
6 Effect of the Administration of an Enteral Milk Supplemented With Proteins to Infants Admitted in a Pediatric Intensive Care Unit Unknown status NCT03901742
7 Feeding Behavior and Taste Sensitivity Before and After Liver or Renal Transplantation Unknown status NCT02931812
8 The (Cost) Effectiveness of Increasing Daily Protein Intake to 1.2 Gram Per Kilo Body Weight on Physical Functioning in Community-dwelling Older Adults With a Habitual Daily Protein Intake < 1.0 Gram Per Kilo Body Weight Completed NCT03712306
9 Bioavailability of Essential Amino Acids From the Common Bean (Phaseolus Vulgaris) in Young Healthy Jamaican Adults Consuming a Typical Meal Completed NCT04118517
10 A Randomized, Double-blind Pilot Study of Polyunsaturated Fatty Acid-optimized Ready-to-use Therapeutic Food, Compared to Standard RUTF, in the Therapy of Severe Acute Malnutrition Completed NCT02053857 Amoxicillin
11 Randomized, Double-blind, Placebo-controlled Trial to Evaluate the Effectiveness of Oral Antibiotics in the Community-based Treatment of Severe Acute Malnutrition in Malawian Children Completed NCT01000298 Placebo;Amoxicillin;Cefdinir
12 Patient Safety Learning Laboratory: Improving Safety of Diagnosis and Therapy in the Inpatient Setting Completed NCT04393909
13 Characterizing the Gut Microbiota Alteration Associated With Severe Acute Malnutrition Completed NCT02413905
14 Glutathione Homeostasis and Oxidant Damage in Kwashiorkor Completed NCT00069134
15 Evaluation of the Effectiveness of a Protein Pulse-Feeding Pattern in Elderly Patients Completed NCT00135590
16 Intervention Study for Validation of Application of a Prediction Model in Maintenance Hemodialysis Patients Completed NCT03642678
17 Distribution of an Energy Rich Formula at Medication Rounds to Individuals Living in Old Peoples Home - Effects on Energy Intake Compared to Standard Nutritional Treatment Completed NCT01259999
18 Mothers Understand And Can do it - Mid Upper Arm Circumference Screening for Malnutrition Performed by Mothers of Children < 5 Years Old Completed NCT01790815
19 ART Pharmacokinetics, Mitochondrial Integrity, and Antioxidant Capacity in Severely Malnourished HIV-infected Malawian Children Completed NCT01529125 zidovudine, lamivudine, nevirapine
20 Effects of Varying Energy Deficits on Protein Turnover at Rest and Carbohydrate Oxidation During Steady-state Exercise Recruiting NCT04910724
21 The Impact of Energy Intake and Short-term Disuse on Muscle Protein Synthesis Rates and Skeletal Muscle Mass in Middle-aged Adults. Recruiting NCT04900701
22 The Underlying Causes Affecting the Response to Dietary Rehabilitation in Severely Acutely Malnourished Children at the Center Hôspitalier Universitaire Sourô Sanou, Bobo Dioulasso, Burkina Faso Recruiting NCT05009823
23 The Underlying Causes Affecting the Response to Dietary Rehabilitation in Severely Acutely Malnourished Children at the Center Hôspitalier Universitaire Sourô Sanou, Bobo Dioulasso, Burkina Faso Recruiting NCT05020847
24 Combining Vitamin E-functionalized CHOcolate With Physical Exercise to Reduce the risK Of Protein Energy Malnutrition in Pre-dementia AGEd People Recruiting NCT05343611
25 Evaluation of Protein Bioavailability, Satiety and Appetite Responses to Protein Fortified Porridge in Older Adults Not yet recruiting NCT05512975
26 Assess Effect of Oral Nutritional Supplementation on Oxidative Stress Levels in Protein-energy Wasting Patients With Continuous Ambulatory Peritoneal Dialysis Not yet recruiting NCT04628117
27 Randomized, Double-blind, Placebo-controlled Trial to Evaluate the Benefit of Antihelminthic Therapy in the Community-Based Treatment of Severe Acute Malnutrition in Malawian Children Withdrawn NCT01395381 Placebo;Albendazole

Search NIH Clinical Center for Protein-Energy Malnutrition

Cochrane evidence based reviews: protein-energy malnutrition

Genetic Tests for Protein-Energy Malnutrition

Anatomical Context for Protein-Energy Malnutrition

Organs/tissues related to Protein-Energy Malnutrition:

MalaCards : Liver, Skeletal Muscle, Thymus, Kidney, Bone Marrow, Small Intestine, Brain

Publications for Protein-Energy Malnutrition

Articles related to Protein-Energy Malnutrition:

(show top 50) (show all 2248)
# Title Authors PMID Year
1
Serum albumin and total lymphocyte count as predictors of outcome in hip fractures. 53 62
19674819 2010
2
The evolution of nutritional status of geriatric patients without cachexia is associated with food intake in sub-acute care. 53 62
19214334 2009
3
Mini Nutritional Assessment (short form) and functional decline in older patients admitted to an acute medical ward. 53 62
18852545 2008
4
Growth hormone treatment during hemodialysis in a randomized trial improves nutrition, quality of life, and cardiovascular risk. 53 62
17554147 2007
5
Are insulin-like growth factor and its binding proteins 1 and 3 clinically useful as markers of malnutrition, sarcopenia and inflammation in end-stage renal disease? 53 62
16391585 2006
6
Nutritional status of patients hospitalised in Poland. 53 62
15714213 2005
7
Early detection of protein energy malnutrition in Sharkia Governorate. 53 62
17187748 2005
8
Serum total protein, albumin and A/G ratio in different grades of protein energy malnutrition. 53 62
15695952 2005
9
Serum leptin concentrations in children with mild protein-energy malnutrition and catch-up growth. 53 62
15491379 2004
10
Serum leptin concentrations in children with mild-to-moderate protein-energy malnutrition. 53 62
14521530 2003
11
[Nutritional status of patients in hospitals in Poland. I. Screening of adult patients]. 53 62
14648979 2003
12
Observations with regard to the National Kidney Foundation K/DOQI clinical practice guidelines concerning serum transthyretin in chronic renal failure. 53 62
12553435 2002
13
Affect of serum leptin on nutritional status in renal disease. 53 62
12171457 2002
14
Leptin levels and IgF-binding proteins in malnourished children: effect of weight gain. 53 62
11827758 2002
15
[Effects of vitamin A supplementation on nutritional markers on the follow-up of malnutrition in children]. 53 62
11470636 2001
16
Use and abuse of albumin: a survey of clinical records from an internal medicine ward. 53 62
11327749 2001
17
Nutritional management of maintenance dialysis patients: why aren't we doing better? 53 62
11375441 2001
18
Serum leptin concentrations during severe protein-energy malnutrition: correlation with growth parameters and endocrine function. 53 62
10909989 2000
19
Relationship between plasma retinol and infectious diseases in the elderly. A case-control study. 53 62
11146333 2000
20
The relationship between plasma leptin and nutritional status in chronic hemodialysis patients. 53 62
10576151 1999
21
Low levels of plasma proteins: malnutrition or inflammation? 53 62
10219494 1999
22
Study of plasma albumin, transferrin, and fibronectin in children with mild to moderate protein-energy malnutrition. 53 62
9972082 1998
23
Depression in the quantity of intestinal secretory IgA and in the expression of the polymeric immunoglobulin receptor in caloric deficiency of the weanling mouse. 53 62
9800951 1998
24
Arginine increases insulin-like growth factor-I production and collagen synthesis in osteoblast-like cells. 53 62
9701468 1998
25
Repletion of the plasma pool of nutrient transport proteins occurs at different rates during the nutritional rehabilitation of severely malnourished children. 53 62
9446846 1998
26
Increased plasma leptin/fat ratio in patients with chronic renal failure: a cause of malnutrition? 53 62
9394318 1997
27
Transferrin kinetics are altered in children with severe protein-energy malnutrition. 53 62
9237939 1997
28
Nutritional status as a predictor of morbidity and mortality in maintenance dialysis patients. 53 62
9152503 1997
29
Enhanced generation of interleukins 1 beta and 6 may contribute to the cachexia of chronic disease. 53 62
9062543 1997
30
Reduction in the quantity of the polymeric immunoglobulin receptor is sufficient to account for the low concentration of intestinal secretory immunoglobulin A in a weanling mouse model of wasting protein-energy malnutrition. 53 62
9082026 1997
31
Assessment of plasma fibronectin in malnourished Nigerian children. 53 62
9106105 1997
32
Albumin kinetics in edematous and nonedematous protein-energy malnourished children. 53 62
8942422 1996
33
Growth hormone-binding proteins and insulin-like growth factor-binding proteins in protein-energy malnutrition, before and after nutritional rehabilitation. 53 62
8929859 1996
34
Radiological, biochemical, and hormonal changes in malnourished children with rachitic manifestations. 53 62
8820618 1996
35
Plasma free carnitine levels in children with malnutrition. 53 62
8016914 1994
36
Postprandial cholecystokinin secretion in elderly with protein-energy undernutrition. 53 62
1372922 1992
37
Can total parenteral nutrition reverse hypoalbuminemia in oncology patients? 53 62
2136002 1990
38
Biochemical profile of heifers with spontaneous humeral fractures suggest that protein-energy malnutrition could be an important factor in the pathology of this disease. 62
36210546 2023
39
Genome Editing and Protein Energy Malnutrition. 62
36454470 2023
40
Quantitative histologic evaluation reveals different degree of liver atrophy in cachectic and starved dogs. 62
36184936 2022
41
Association of Subjective Global Assessment with outcomes in the intensive care unit: A retrospective cohort study. 62
36127861 2022
42
Pathogenesis of Severe Liver Injury in Patients with Anorexia Nervosa: A Report of Two Cases and a Literature Review. 62
36130885 2022
43
Healthy aging and chronic kidney disease. 62
36328991 2022
44
Impact of malnutrition management E-Learning module on general practitioners' Knowledge. 62
36410769 2022
45
Effects of blending ratios and baking temperature on physicochemical properties and sensory acceptability of biscuits prepared from pumpkin, common bean, and wheat composite flour. 62
36247146 2022
46
Protein Intake and Oral Health in Older Adults-A Narrative Review. 62
36364741 2022
47
Eye movement impairments in children with malnutrition. 62
35262928 2022
48
Clinical Profile and Immediate Outcome of Pyogenic Meningitis in Children. 62
36189547 2022
49
Protein-energy malnutrition worsens hospitalization outcomes of patients with pancreatic cancer undergoing open pancreaticoduodenectomy. 62
35524935 2022
50
Fluid Overload and Tissue Sodium Accumulation as Main Drivers of Protein Energy Malnutrition in Dialysis Patients. 62
36364751 2022

Variations for Protein-Energy Malnutrition

Expression for Protein-Energy Malnutrition

Search GEO for disease gene expression data for Protein-Energy Malnutrition.

Pathways for Protein-Energy Malnutrition

GO Terms for Protein-Energy Malnutrition

Cellular components related to Protein-Energy Malnutrition according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 10.27 ALB CP GPT HP LTF MGAM
2 extracellular region GO:0005576 10.09 ALB CP HP IGF1 IL6 LEP
3 blood microparticle GO:0072562 9.97 TF HP CP ALB
4 recycling endosome GO:0055037 9.92 TNF TF LTF CFTR
5 extracellular space GO:0005615 9.75 ALB CP GPT HP IGF1 IL6
6 phagocytic vesicle lumen GO:0097013 9.56 MPO LTF

Biological processes related to Protein-Energy Malnutrition according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 10.07 TNF MPO LTF LEP IL6 IGF1
2 regulation of insulin secretion GO:0050796 9.97 TNF LEP IL6
3 response to activity GO:0014823 9.95 TNF LEP IL6
4 iron ion homeostasis GO:0055072 9.91 TF LTF CP
5 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 9.88 TNF LEP IL6
6 iron ion transport GO:0006826 9.8 CP LTF TF
7 bone mineralization involved in bone maturation GO:0035630 9.76 LEP IGF1
8 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.76 TNF LEP IL6 IGF1
9 response to gold nanoparticle GO:1990268 9.67 TNF MPO
10 negative regulation of lipid storage GO:0010888 9.43 TNF LEP IL6
11 retina homeostasis GO:0001895 9.23 TF PIGR LTF ALB

Molecular functions related to Protein-Energy Malnutrition according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 alpha-glucosidase activity GO:0090599 8.96 SI MGAM
2 alpha-1,4-glucosidase activity GO:0004558 8.92 SI MGAM

Sources for Protein-Energy Malnutrition

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....