MCID: PRT014
MIFTS: 50

Protein S Deficiency

Categories: Blood diseases, Cardiovascular diseases, Rare diseases

Aliases & Classifications for Protein S Deficiency

MalaCards integrated aliases for Protein S Deficiency:

Name: Protein S Deficiency 12 74 52 25 29 54 6 43 15 39 71
Hereditary Thrombophilia Due to Protein S Deficiency 25
Protein S Deficiency Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2451
MeSH 43 D018455
NCIt 49 C99026
SNOMED-CT 67 1563006
ICD10 32 D68.59
UMLS 71 C0242666

Summaries for Protein S Deficiency

Genetics Home Reference : 25 Protein S deficiency is a disorder of blood clotting. People with this condition have an increased risk of developing abnormal blood clots. Individuals with mild protein S deficiency are at risk of a type of clot called a deep vein thrombosis (DVT) that occurs in the deep veins of the arms or legs. If a DVT travels through the bloodstream and lodges in the lungs, it can cause a life-threatening clot known as a pulmonary embolism (PE). Other factors can raise the risk of abnormal blood clots in people with mild protein S deficiency. These factors include increasing age, surgery, immobility, or pregnancy. The combination of protein S deficiency and other inherited disorders of blood clotting can also influence risk. Many people with mild protein S deficiency never develop an abnormal blood clot, however. In severe cases of protein S deficiency, infants develop a life-threatening blood clotting disorder called purpura fulminans soon after birth. Purpura fulminans is characterized by the formation of blood clots within small blood vessels throughout the body. These blood clots disrupt normal blood flow and can lead to death of body tissue (necrosis). Widespread blood clotting uses up all available blood clotting proteins. As a result, abnormal bleeding occurs in various parts of the body and is often noticeable as large, purple skin lesions. Individuals who survive the newborn period may experience recurrent episodes of purpura fulminans.

MalaCards based summary : Protein S Deficiency, also known as hereditary thrombophilia due to protein s deficiency, is related to sagittal sinus thrombosis and central retinal artery occlusion. An important gene associated with Protein S Deficiency is PROS1 (Protein S), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Enoxaparin and Thrombin have been mentioned in the context of this disorder. Affiliated tissues include skin, heart and lung, and related phenotypes are homeostasis/metabolism and cardiovascular system

NIH Rare Diseases : 52 Protein S deficiency is a disorder that causes abnormal blood clotting. When someone bleeds, the blood begins a complicated series of rapid chemical reactions involving proteins called blood coagulation factors to stop the bleeding. Other proteins in the blood, such as protein S, usually regulate these chemical reactions to prevent excessive clotting. When protein S is missing (deficient), clotting may not be regulated normally and affected individuals have an increased risk of forming a blood clot called a thrombosis . People at risk to have protein S deficiency are those with an individual or family history of multiple blood clots in the veins. Treatment may include taking medication known as blood thinners to decrease the chance of developing a blood clot.

Wikipedia : 74 Protein S deficiency is a disorder associated with increased risk of venous thrombosis. Protein S, a... more...

Related Diseases for Protein S Deficiency

Diseases related to Protein S Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 353, show less)
# Related Disease Score Top Affiliating Genes
1 sagittal sinus thrombosis 30.4 SERPINC1 F5 F3 F2
2 central retinal artery occlusion 30.2 SERPINC1 F2
3 esophageal varix 30.1 SERPINC1 F3 F2
4 heparin-induced thrombocytopenia 30.1 SERPINC1 F3 F10
5 factor v leiden thrombophilia 30.0 MTHFR F5
6 intracranial embolism 29.9 SERPINC1 F3 F2
7 branch retinal artery occlusion 29.8 SERPINC1 MTHFR F3 F2
8 moyamoya disease 1 29.8 SERPINC1 MTHFR F3 F2
9 lateral sinus thrombosis 29.8 SERPINC1 MTHFR F2
10 mastoiditis 29.8 SERPINC1 MTHFR F2
11 severe pre-eclampsia 29.7 SERPINC1 F5 APOH
12 coronary thrombosis 29.7 SERPINE1 SERPINC1 F3
13 purpura fulminans 29.6 SERPINC1 PROS1 PROC F5 F3 F2
14 leech infestation 29.6 SERPINC1 F3 F10
15 compartment syndrome 29.6 SERPINC1 F8 F3 F2
16 splenic infarction 29.5 SERPINC1 F3 F2 APOH
17 portal hypertension 29.5 SERPINE1 F3 F2
18 factor xii deficiency 29.5 SERPINC1 F5 F3 APOH
19 purpura 29.5 THBD SERPINC1 PROS1 PROC F3 F2
20 infective endocarditis 29.4 SERPINE1 F2 APOH
21 budd-chiari syndrome 29.3 SERPINC1 MTHFR F5 F3 F2 APOH
22 vitamin k deficiency bleeding 29.3 SERPINC1 PROS1 F8 F3 F2
23 sticky platelet syndrome 29.3 SERPINE1 SERPINC1 F5
24 endocarditis 29.3 SERPINE1 SERPINC1 F2 APOH
25 thrombotic thrombocytopenic purpura 29.3 THBD SERPINC1 F3 APOH
26 osteonecrosis 29.2 SERPINE1 SERPINC1 MTHFR F2
27 antithrombin iii deficiency 29.1 SERPINC1 MTHFR F5 F2 F10 APOH
28 sneddon syndrome 29.0 SERPINC1 F8 F5 F2 APOH
29 livedoid vasculitis 28.9 SERPINE1 SERPINC1 MTHFR F2
30 ischemic colitis 28.8 SERPINE1 SERPINC1 F5 F2 APOH
31 venous insufficiency 28.8 SERPINE1 MTHFR F5 F2
32 central retinal vein occlusion 28.8 SERPINC1 MTHFR F8 F5 F3 F2
33 cerebral sinovenous thrombosis 28.8 PROS1 MTHFR F5 F3 F2 APOH
34 varicose veins 28.7 THBD SHBG SERPINC1 MTHFR F5 F2
35 pulmonary hypertension 28.6 THBD SERPINE1 SERPINC1 F3 F2
36 eclampsia 28.6 THBD SERPINE1 SERPINC1 MTHFR F2
37 portal vein thrombosis 28.5 SERPINE1 SERPINC1 PROC MTHFR F5 F2
38 retinal vein occlusion 28.5 SERPINE1 SERPINC1 MTHFR F5 F3 F2
39 disseminated intravascular coagulation 28.5 THBD SERPINE1 SERPINC1 F5 F3 F2
40 placental abruption 28.4 THBD SERPINC1 PROC MTHFR F5 F2
41 acute myocardial infarction 28.4 THBD SERPINE1 SERPINC1 F3 F10
42 protein c deficiency 28.3 THBD SERPINE1 SERPINC1 PROC MTHFR F5
43 cerebrovascular disease 28.2 THBD SERPINE1 MTHFR F8 F5 F2
44 intracranial thrombosis 28.2 SERPINC1 MTHFR F8 F5 F3 F2
45 homocysteinemia 28.1 THBD SERPINE1 SERPINC1 MTHFR F5 F2
46 kidney disease 28.1 THBD SERPINE1 MTHFR F3 F10
47 arteriosclerosis 28.0 THBD SHBG SERPINE1 SERPINC1 F3
48 intracranial hypertension 28.0 SERPINE1 SERPINC1 MTHFR F5 F3 F2
49 catastrophic antiphospholipid syndrome 28.0 SERPINE1 PROC MTHFR F5 F3 APOH
50 retinal artery occlusion 27.9 SERPINE1 SERPINC1 MTHFR F8 F5 F2
51 patent foramen ovale 27.8 SERPINE1 SERPINC1 MTHFR F5 F3 F2
52 heart disease 27.8 SERPINE1 SERPINC1 MTHFR F8 F3 F2
53 thrombocytopenia 27.7 THBD SERPINE1 SERPINC1 F5 F3 F2
54 antiphospholipid syndrome 27.6 THBD SERPINE1 SERPINC1 MTHFR F5 F3
55 stroke, ischemic 27.5 THBD SERPINE1 SERPINC1 MTHFR F5 F3
56 thrombophlebitis 27.4 SERPINE1 SERPINC1 PROS1 PROC MTHFR F8
57 thrombophilia due to thrombin defect 27.3 THBD SERPINE1 SERPINC1 PROC MTHFR F8
58 hellp syndrome 27.3 THBD SERPINE1 SERPINC1 MTHFR F5 F3
59 vascular disease 27.1 THBD SERPINE1 SERPINC1 MTHFR F8 F5
60 pre-eclampsia 27.1 THBD SERPINE1 SERPINC1 MTHFR F8 F5
61 thrombosis 26.9 THBD SERPINE1 SERPINC1 PROS1 PROC MTHFR
62 thrombophilia 26.8 THBD SERPINE1 SERPINC1 PROS1 PROC MTHFR
63 pulmonary embolism 26.7 THBD SERPINE1 SERPINC1 PROS1 PROC MTHFR
64 thrombophilia due to activated protein c resistance 26.1 THBD SHBG SERPINE1 SERPINC1 MTHFR F8
65 myocardial infarction 25.8 THBD SHBG SERPINE1 SERPINC1 MTHFR F8
66 thrombophilia due to protein s deficiency, autosomal dominant 12.9
67 thrombophilia due to protein s deficiency, autosomal recessive 12.9
68 severe hereditary thrombophilia due to congenital protein s deficiency 12.6
69 paracetamol poisoning 10.4 F5 F2
70 waterhouse-friderichsen syndrome 10.4 SERPINC1 F2
71 vulvar angiokeratoma 10.4 SERPINC1 F3
72 gastric hemangioma 10.4 F3 F2
73 renal pelvis squamous cell carcinoma 10.4 F3 F2
74 cavernous sinus thrombosis 10.4 SERPINC1 F2
75 papillary adenofibroma 10.4 F3 F2
76 thoracic outlet syndrome 10.4 SERPINC1 F2
77 emphysematous cholecystitis 10.4 F3 F2
78 cholesterol embolism 10.4 SERPINC1 F2
79 femoral neuropathy 10.4 F3 F2
80 femoral vein thrombophlebitis 10.4 PROC F2
81 may-thurner syndrome 10.4 F5 APOH
82 qualitative platelet defect 10.4 F3 F2
83 acanthamoeba keratitis 10.4 F5 APOH
84 hemoglobin e disease 10.4 F5 F2
85 hemopericardium 10.3 F3 F2
86 hepatic coma 10.3 SERPINC1 F2
87 chickenpox 10.3
88 mediastinitis 10.3 F5 F2
89 prothrombin-related thrombophilia 10.3 MTHFR F2
90 intracranial hypotension 10.3 F3 F2
91 splenic sequestration 10.3 F3 F2
92 thrombophlebitis migrans 10.3 SERPINC1 F3
93 active peptic ulcer disease 10.3 F3 F2
94 blue toe syndrome 10.3 SERPINC1 F3 F2
95 giant hemangioma 10.3 SERPINC1 F3 F2
96 volkmann contracture 10.3 SERPINC1 F3 F2
97 hantavirus pulmonary syndrome 10.3 F3 F2
98 nephrotic syndrome 10.2
99 mitral valve stenosis 10.2 SERPINC1 F3 F2
100 analbuminemia 10.2 F3 F2
101 intracranial hypertension, idiopathic 10.2 F3 F2
102 thrombocytosis 10.2 SERPINC1 F3 F2
103 systemic lupus erythematosus 10.2
104 ebola hemorrhagic fever 10.2 F5 F3
105 factor v and factor viii, combined deficiency of, 2 10.2 F8 F5
106 vasculitis 10.2
107 pik3ca-related overgrowth syndrome 10.2
108 arteritic anterior ischemic optic neuropathy 10.2 MTHFR F5 F2
109 lemierre's syndrome 10.1 MTHFR F3 F2
110 raynaud phenomenon 10.1 THBD APOH
111 porencephaly 10.1 MTHFR F5 F2
112 lupus erythematosus 10.1
113 gastroschisis 10.1 MTHFR F5 F2
114 amino acid metabolic disorder 10.1 SERPINC1 MTHFR F2
115 anuria 10.1 F3 F2
116 nephrosclerosis 10.1 MTHFR F3 F2
117 heart valve disease 10.1 F3 F2 APOH
118 hemoglobinuria 10.1 THBD SERPINC1 F2
119 acquired von willebrand syndrome 10.1 F8 F3
120 paroxysmal nocturnal hemoglobinuria 10.1 THBD SERPINC1 F2
121 alpha-2-plasmin inhibitor deficiency 10.1 SERPINC1 F8 F2
122 calciphylaxis 10.1
123 pregnancy loss, recurrent 1 10.1 MTHFR F5 APOH
124 synovial angioma 10.1 F8 F3 F2
125 tricuspid valve insufficiency 10.1 F3 F2
126 acquired hemophilia a 10.1 F8 F5 F3
127 von willebrand disease, type 1 10.0 F8 F3 F2
128 cardiac tamponade 10.0 F8 F3 F2
129 hemolytic-uremic syndrome 10.0 THBD F3 F2
130 fibrinolytic defect 10.0 SERPINE1 SERPINC1
131 aphasia 10.0
132 hemiplegia 10.0
133 cardiac tuberculosis 10.0 SERPINE1 SERPINC1
134 kwashiorkor 10.0 SHBG F2
135 thyroid angiosarcoma 10.0 THBD F8
136 puerperal pulmonary embolism 10.0 SERPINC1 F10 APOH
137 hepatic infarction 10.0 SERPINC1 F3 F2 APOH
138 papilledema 10.0 SERPINC1 F3 F2 APOH
139 grange syndrome 10.0 THBD MTHFR F3
140 inflammatory bowel disease 10.0
141 colitis 10.0
142 hyperparathyroidism 10.0
143 tricuspid valve disease 10.0 F3 F2
144 angiodysplasia 10.0 F8 F3
145 marantic endocarditis 10.0 SERPINC1 MTHFR F3 F2
146 intracranial sinus thrombosis 10.0 SERPINC1 MTHFR F3 F2
147 nonarteritic anterior ischemic optic neuropathy 10.0 SERPINC1 MTHFR F5 F2
148 ovarian hyperstimulation syndrome 10.0 SHBG SERPINC1 F5
149 thrombasthenia 9.9 MTHFR F5 F3 F2
150 dysfibrinogenemia, congenital 9.9 THBD SERPINC1 F5 F2
151 atrial heart septal defect 9.9 SERPINC1 MTHFR F3 F2
152 immune deficiency disease 9.9
153 arteriovenous malformation 9.9
154 toxic shock syndrome 9.9
155 ischemia 9.9
156 peritonitis 9.9
157 ulcerative colitis 9.9
158 crohn's disease 9.9
159 scotoma 9.9
160 sickle cell disease 9.9
161 splenomegaly 9.9
162 headache 9.9
163 argentine hemorrhagic fever 9.9 SERPINE1 SERPINC1
164 polycythemia vera 9.9 THBD F5 F2
165 fournier gangrene 9.9 SERPINC1 F8 F3 F2
166 cerebral palsy 9.9 PROC MTHFR F5 F2
167 factor x deficiency 9.9 F5 F3 F2 F10
168 von willebrand's disease 9.8 F8 F5 F3 F2
169 colorectal cancer 9.8
170 migraine with or without aura 1 9.8
171 celiac disease 1 9.8
172 myeloma, multiple 9.8
173 orthostatic intolerance 9.8
174 exanthem 9.8
175 lymphocytic leukemia 9.8
176 visual epilepsy 9.8
177 secondary hyperparathyroidism 9.8
178 dilated cardiomyopathy 9.8
179 status epilepticus 9.8
180 cellulitis 9.8
181 acquired immunodeficiency syndrome 9.8
182 connective tissue disease 9.8
183 end stage renal failure 9.8
184 priapism 9.8
185 seizure disorder 9.8
186 primary thrombocytopenia 9.8 F3 F2
187 homocystinuria 9.8 THBD SERPINC1 MTHFR F5
188 atrial fibrillation 9.8 SERPINC1 F3 F2 F10
189 peripheral vertigo 9.8 SERPINC1 F5 F3 F2 APOH
190 blood protein disease 9.8 SERPINC1 PROS1 MTHFR F3 F2
191 brachydactyly, type d 9.8 F8 F10
192 amaurosis fugax 9.7 SERPINE1 MTHFR F5
193 spinal cord infarction 9.7 SERPINC1 MTHFR F5 F2 APOH
194 sudden sensorineural hearing loss 9.7 SERPINC1 MTHFR F5 F2 APOH
195 chronic venous insufficiency 9.7 SERPINE1 MTHFR F2
196 retinal vascular occlusion 9.7 SERPINC1 MTHFR F5 F2 APOH
197 neonatal stroke 9.7 SERPINE1 PROC MTHFR
198 complement component 4, partial deficiency of 9.7
199 exudative vitreoretinopathy 1 9.7
200 leukemia, chronic lymphocytic 9.7
201 myelopathy, htlv-1-associated 9.7
202 ovarian cancer 9.7
203 pneumothorax, primary spontaneous 9.7
204 retinal detachment 9.7
205 rheumatoid arthritis 9.7
206 tuberous sclerosis 1 9.7
207 lymphoma, hodgkin, classic 9.7
208 ocular motor apraxia 9.7
209 graves disease 1 9.7
210 ataxia and polyneuropathy, adult-onset 9.7
211 kearns-sayre syndrome 9.7
212 malignant atrophic papulosis 9.7
213 sickle cell anemia 9.7
214 lymphoma, non-hodgkin, familial 9.7
215 aortic aneurysm, familial thoracic 1 9.7
216 coronary heart disease 1 9.7
217 human immunodeficiency virus type 1 9.7
218 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.7
219 diabetes mellitus, ketosis-prone 9.7
220 leukemia, acute lymphoblastic 9.7
221 beta-thalassemia 9.7
222 gastrointestinal ulceration, recurrent, with dysfunctional platelets 9.7
223 deficiency anemia 9.7
224 adult t-cell leukemia 9.7
225 c1 inhibitor deficiency 9.7
226 lymphoma 9.7
227 cutaneous t cell lymphoma 9.7
228 pain agnosia 9.7
229 crest syndrome 9.7
230 agraphia 9.7
231 scoliosis 9.7
232 metal allergy 9.7
233 thalassemia 9.7
234 short bowel syndrome 9.7
235 protein-losing enteropathy 9.7
236 interstitial nephritis 9.7
237 abducens nerve disease 9.7
238 amnestic disorder 9.7
239 retinal vasculitis 9.7
240 graves' disease 9.7
241 leiomyoma 9.7
242 telangiectasis 9.7
243 hereditary spherocytosis 9.7
244 carotid stenosis 9.7
245 diarrhea 9.7
246 alexia 9.7
247 tuberous sclerosis 9.7
248 panniculitis 9.7
249 pneumothorax 9.7
250 epilepsy 9.7
251 optic nerve disease 9.7
252 neuroma 9.7
253 maxillary sinusitis 9.7
254 transient cerebral ischemia 9.7
255 pharyngitis 9.7
256 gastroenteritis 9.7
257 dermatitis 9.7
258 acute pancreatitis 9.7
259 pulmonary tuberculosis 9.7
260 astrocytoma 9.7
261 gallbladder cancer 9.7
262 lipid metabolism disorder 9.7
263 tropical spastic paraparesis 9.7
264 central nervous system disease 9.7
265 mixed connective tissue disease 9.7
266 aortic aneurysm 9.7
267 myofibroma 9.7
268 dysgraphia 9.7
269 liver cirrhosis 9.7
270 central nervous system vasculitis 9.7
271 human immunodeficiency virus infectious disease 9.7
272 pneumonia 9.7
273 hemolytic anemia 9.7
274 congestive heart failure 9.7
275 plasma cell neoplasm 9.7
276 anterior spinal artery syndrome 9.7
277 juvenile pilocytic astrocytoma 9.7
278 t-cell leukemia 9.7
279 peptic ulcer disease 9.7
280 myocarditis 9.7
281 collagen disease 9.7
282 nervous system disease 9.7
283 neuropathy 9.7
284 exophthalmos 9.7
285 toxoplasmosis 9.7
286 keloid disorder 9.7
287 48,xyyy 9.7
288 anca-associated vasculitis 9.7
289 banti's syndrome 9.7
290 erythrokeratoderma ''en cocardes'' 9.7
291 granulocytopenia 9.7
292 htlv-1 associated myelopathy/tropical spastic paraparesis 9.7
293 nodular regenerative hyperplasia 9.7
294 spastic paraparesis 9.7
295 warfarin syndrome 9.7
296 aneurysm 9.7
297 cytomegalovirus infection 9.7
298 head injury 9.7
299 tremor 9.7
300 inflammatory myopathy with abundant macrophages 9.7
301 avascular necrosis 9.7
302 pediatric arterial ischemic stroke 9.7
303 hepatoportal sclerosis 9.7
304 acute liver failure 9.7
305 cardiogenic shock 9.7
306 thrombotic microangiopathy 9.7
307 hemarthrosis 9.7 F8 F3 F2 F10
308 acquired hemophilia 9.7 F8 F5 F3 F10
309 dic in newborn 9.7 SERPINE1 SERPINC1 F3 F2
310 carotid artery occlusion 9.7 THBD F8 F5 APOH
311 glanzmann thrombasthenia 9.7 F8 F3 F2 F10
312 takayasu arteritis 9.6 THBD SERPINC1 F3 F2 APOH
313 hepatic vascular disease 9.6 SERPINE1 SERPINC1 F3 F2
314 adult respiratory distress syndrome 9.6 THBD SERPINE1 F2
315 placental insufficiency 9.6 SERPINE1 SERPINC1 F3 F2
316 prothrombin deficiency, congenital 9.6 SERPINC1 F5 F2 F10 APOH
317 quebec platelet disorder 9.6 SERPINE1 F5 F10
318 coronary artery anomaly 9.6 SERPINE1 SERPINC1 F3 F2
319 intermittent claudication 9.6 SERPINE1 SERPINC1 F2 APOH
320 cryptogenic cirrhosis 9.6 SERPINE1 MTHFR F5 F2
321 prothrombin deficiency 9.5 SERPINC1 F8 F3 F2 F10
322 factor vii deficiency 9.5 SERPINC1 F8 F3 F2 F10
323 hemophilia b 9.5 SERPINC1 F8 F3 F2 F10
324 placenta disease 9.5 SERPINC1 MTHFR F5 F3 F2 APOH
325 factor v deficiency 9.5 F8 F5 F3 F2 F10
326 buerger disease 9.5 SERPINE1 MTHFR F2 APOH
327 factor viii deficiency 9.5 F8 F5 F3 F2 F10
328 carotid artery thrombosis 9.5 SERPINE1 SERPINC1 F3 F10
329 behcet syndrome 9.3 THBD SERPINC1 MTHFR F5 F2 APOH
330 atherosclerosis susceptibility 9.3 THBD SERPINE1 MTHFR F3
331 meningococcemia 9.3 THBD SERPINE1 SERPINC1 PROC F5
332 acute promyelocytic leukemia 9.2 THBD SERPINE1 SERPINC1 F3 F2
333 hepatic veno-occlusive disease 9.1 THBD SERPINE1 SERPINC1 F8 F3
334 peripheral vascular disease 9.1 THBD SERPINE1 SERPINC1 F5 F3 F2
335 post-thrombotic syndrome 9.1 SERPINE1 SERPINC1 F8 F5 F3 F2
336 factor xiii deficiency 9.1 SERPINE1 SERPINC1 F8 F5 F3 F2
337 essential thrombocythemia 9.0 THBD SERPINE1 SERPINC1 MTHFR F3 F2
338 factor xi deficiency 9.0 THBD SERPINC1 F8 F5 F3 F2
339 legg-calve-perthes disease 8.9 THBD SERPINE1 SERPINC1 MTHFR F5 APOH
340 hypothyroidism 8.9 SHBG SERPINE1 F8 F3 F2
341 osteoporosis 8.9 SHBG SERPINE1 SERPINC1 MTHFR F3
342 malaria 8.9 THBD SERPINE1 SERPINC1 MTHFR F3 F2
343 blood platelet disease 8.9 THBD SERPINC1 F8 F3 F2 F10
344 cardiovascular system disease 8.7 THBD SHBG SERPINE1 SERPINC1 MTHFR F3
345 afibrinogenemia, congenital 8.7 SERPINE1 SERPINC1 F8 F5 F3 F2
346 inherited blood coagulation disease 8.4 THBD SERPINC1 PROC MTHFR F8 F5
347 diabetes mellitus, noninsulin-dependent 8.4 THBD SHBG SERPINE1 PROC MTHFR F8
348 hemorrhagic disease 8.3 THBD SERPINE1 SERPINC1 F8 F5 F3
349 vein disease 8.3 SERPINE1 SERPINC1 PROS1 PROC MTHFR F8
350 hypertension, essential 8.2 THBD SHBG SERPINE1 SERPINC1 PROC MTHFR
351 diabetes mellitus 8.1 THBD SHBG SERPINE1 SERPINC1 MTHFR F8
352 blood coagulation disease 7.7 THBD SERPINE1 SERPINC1 MTHFR F8 F5
353 pulmonary artery disease 7.5 THBD SERPINE1 SERPINC1 PROS1 MTHFR F8

Graphical network of the top 20 diseases related to Protein S Deficiency:



Diseases related to Protein S Deficiency

Symptoms & Phenotypes for Protein S Deficiency

MGI Mouse Phenotypes related to Protein S Deficiency:

45 (showing 5, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.03 APOH F10 F2 F3 F5 F8
2 cardiovascular system MP:0005385 9.97 F10 F2 F3 F5 PROC PROS1
3 integument MP:0010771 9.7 F2 F3 F5 MTHFR PROS1 SERPINE1
4 liver/biliary system MP:0005370 9.5 F5 MTHFR PROC PROS1 SERPINC1 SERPINE1
5 mortality/aging MP:0010768 9.4 APOH F10 F2 F3 F5 F8

Drugs & Therapeutics for Protein S Deficiency

Drugs for Protein S Deficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 24, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Enoxaparin Approved Phase 3 9005-49-6 772
2
Thrombin Approved, Investigational
3
Methyltestosterone Approved 58-18-4 6010
4
Testosterone Approved, Experimental, Investigational 58-22-0, 481-30-1 6013 10204
5
Testosterone undecanoate Approved, Investigational 5949-44-0
6
Testosterone enanthate Approved 315-37-7 9416
7
Vitamin C Approved, Nutraceutical 50-81-7 5785 54670067
8 Hemostatics
9 Coagulants
10 Factor VIII
11 Estrogens
12 Trace Elements
13 Micronutrients
14 Vitamins
15 Anabolic Agents
16 Antioxidants
17 Hormone Antagonists
18 Nutrients
19 Protective Agents
20 Antineoplastic Agents, Hormonal
21 Testosterone 17 beta-cypionate
22 Hormones
23 Androgens
24 Estrogens, Conjugated (USP)

Interventional clinical trials:

(showing 6, show less)
# Name Status NCT ID Phase Drugs
1 Essai thérapeutique randomisé Multicentrique en Double Insu, Comparant l'énoxaparine 40mg Versus Placebo, en Une Injection Sous-cutanée Quotidienne, Dans Les Fausses Couches spontanées récurrentes inexpliquées Terminated NCT00740545 Phase 3 enoxaparine 40 mg daily;placebo
2 Prevalence of Clinical and Laboratory Markers of Hypofibrinolysis in Psychotic Patients Completed NCT01487291
3 Calibrated Automated Thrombogram: A Scandinavian Multicenter Study Completed NCT03313531 Treatment with recombinant coagulation factor
4 Thromboprophylaxis in Pregnant Women in Hospital: A Prospective Clinical Trial Recruiting NCT02600260 Enoxaparin
5 Serum Androgen Levels as a Marker for the Severity of Preeclampsia Active, not recruiting NCT03744988
6 Validation of a Novel Dabigatran Based Peri-Operative Bridging Anticoagulation Protocol for Patients on Chronic Warfarin Therapy Withdrawn NCT01810237 Dabigatran.

Search NIH Clinical Center for Protein S Deficiency

Cochrane evidence based reviews: protein s deficiency

Genetic Tests for Protein S Deficiency

Genetic tests related to Protein S Deficiency:

# Genetic test Affiliating Genes
1 Protein S Deficiency 29 PROS1

Anatomical Context for Protein S Deficiency

MalaCards organs/tissues related to Protein S Deficiency:

40
Skin, Heart, Lung, Testes, T Cells, Liver, Kidney

Publications for Protein S Deficiency

Articles related to Protein S Deficiency:

(showing 1247, show less)
# Title Authors PMID Year
1
Compound heterozygous mutations in the PROS1 gene responsible for quantitative and qualitative protein S deficiency. 54 61
19826897 2009
2
Gross deletions/duplications in PROS1 are relatively common in point mutation-negative hereditary protein S deficiency. 54 61
19466456 2009
3
Prevalence of thrombophilias in patients presenting for bariatric surgery. 54 61
19579050 2009
4
Hereditary protein S deficiency from a novel large deletion mutation of the PROS1 gene detected by multiplex ligation-dependent probe amplification (MLPA). 54 61
19168201 2009
5
High long-term absolute risk of recurrent venous thromboembolism in patients with hereditary deficiencies of protein S, protein C or antithrombin. 54 61
19132194 2009
6
Deficiency of the natural anticoagulant proteins in women with pregnancy related venous thromboembolism. 54 61
19514602 2009
7
Etiology of hypercoagulable state in women with recurrent fetal loss without other causes of miscarriage from Southern Italy: new clinical target for antithrombotic therapy. 54 61
19707467 2008
8
Confirmation of inherited protein S deficiency by PROS1 mutational screening: Identification of three novel PROS1 mutations and haplotype analysis of p.Q279X recurrence. 54 61
18841302 2008
9
Thrombophilic dimension of recurrent fetal loss in Indian patients. 54 61
18685442 2008
10
Venous thromboembolism in live kidney donors--a prospective study. 54 61
18791446 2008
11
Inherited protein S deficiency as a result of a large duplication mutation of the PROS1 gene detected by multiplex ligation-dependent probe amplification. 54 61
18489710 2008
12
Late onset thrombosis in a case of severe protein S deficiency due to compound heterozygosity for PROS1 mutations. 54 61
18433462 2008
13
Severe protein S deficiency resulting from two novel mutations in PROS1 presenting with a relatively mild clinical phenotype. 54 61
18485091 2008
14
Arteriovenous thrombosis in chronic renal failure patients receiving renal replacement therapy. 54 61
18760065 2008
15
PROS1 analysis in 87 pedigrees with hereditary protein S deficiency demonstrates striking genotype-phenotype associations. 54 61
18435454 2008
16
[Rare thrombophilic states]. 54 61
18394759 2008
17
FV Leiden mutation and risk of recurrent venous thromboembolism in Serbian population. 54 61
17549437 2008
18
[Venous thromboembolism and liver cirrhosis]. 54 61
18662076 2008
19
Functional characterization of twelve natural PROS1 mutations associated with anticoagulant protein S deficiency. 54 61
18322254 2008
20
Evidence-based indications for thrombophilia screening. 54 61
18512539 2008
21
Protein S deficiency, epileptic seizures, sagittal sinus thrombosis and hemorrhagic infarction after ingestion of dimenhydrinate. 54 61
18382986 2008
22
Anticoagulant therapy after retinal vein occlusion in patients with protein S deficiency (Protein S deficiency with homozygous factor V Leiden mutation in central retinal vein occlusion. Vol. 42[4]). 54 61
18059510 2007
23
Prothrombotic risk factors in children with hemiplegic cerebral palsy. 54 61
17875083 2007
24
A large deletion of the PROS1 gene in a deep vein thrombosis patient with protein S deficiency. 54 61
17938802 2007
25
An Sp1 binding site mutation of the PROS1 promoter in a patient with protein S deficiency. 54 61
17596203 2007
26
Arterial thrombosis and the role of thrombophilia. 54 61
17768691 2007
27
Patent foramen ovale and prothrombotic markers in young stroke patients. 54 61
17762528 2007
28
The prevalence of thrombophilia and venous thromboembolism in total knee arthroplasty. 54 61
17710975 2007
29
Mechanisms of ischemic stroke in HIV-infected patients. 54 61
17438215 2007
30
Utility of the clinical practice of administering thrombophilic screening and antithrombotic prophylaxis with low-molecular-weight heparin to healthy donors treated with G-CSF for mobilization of peripheral blood stem cells. 54 61
17557562 2007
31
Relationship between thrombophilic disorders and type of severe early-onset hypertensive disorder of pregnancy. 54 61
18066962 2007
32
One novel and one recurrent mutation in the PROS1 gene cause type I protein S deficiency in patients with pulmonary embolism associated with deep vein thrombosis. 54 61
16868938 2006
33
Identification of a novel PROS1 c.1113T-->GG frameshift mutation in a family with mixed type I/type III protein S deficiency. 54 61
16885060 2006
34
The relationship between pregnancy induced hypertension and congenital thrombophilia. 54 61
16883445 2006
35
Utility of thrombin-generation assay in the screening of factor V G1691A (Leiden) and prothrombin G20210A mutations and protein S deficiency. 54 61
16469858 2006
36
Thrombophilia testing in patients with venous thrombosis. 54 61
16055356 2005
37
Large deletions of the PROS1 gene in a large fraction of mutation-negative patients with protein S deficiency. 54 61
16363235 2005
38
Ischemic stroke subtypes and thrombophilia in young and elderly Brazilian stroke patients admitted to a rehabilitation hospital. 54 61
16109904 2005
39
The relationship of the factor V Leiden mutation and pregnancy outcomes for mother and fetus. 54 61
16135581 2005
40
[Venous thromboembolic disease: which coagulation screening, for whom, when?]. 54 61
16240880 2005
41
Purpura fulminans as a sequel to erythema nodosum in a child with homozygous Leiden mutation and acquired protein S deficiency. 54 61
16188867 2005
42
The incidence of venous thromboembolism in carriers of antithrombin, protein C or protein S deficiency associated with the HR2 haplotype of factor V: a family cohort study. 54 61
15978097 2005
43
Thrombophilia in children with cystic fibrosis. 54 61
15678507 2005
44
Risk factors for thrombophilia in extrahepatic portal vein obstruction. 54 61
15726653 2005
45
Risk of a first venous thrombotic event in carriers of a familial thrombophilic defect. The European Prospective Cohort on Thrombophilia (EPCOT). 54 61
15748234 2005
46
[Factor V Leiden, FII G20210A, MTHFR C677T mutations as risk factors for venous thrombosis during pregnancy and puerperium]. 54 61
15790048 2005
47
Maternal and paternal thrombophilia: risk factors for perinatal mortality. 54 61
15713144 2005
48
Excellent outcome in infants and small children with thrombophilias undergoing kidney transplantation. 54 61
15667609 2005
49
Management options for thrombophilias. 54 61
15706484 2005
50
Recurrent miscarriage syndrome and infertility due to blood coagulation protein/platelet defects: a review and update. 54 61
15678268 2005
51
Anterior spinal artery syndrome in two children with genetic thrombotic disorders. 54 61
15832907 2005
52
[Primary thrombophilia. Report of 93 cases and 12 asymptomatic relatives]. 54 61
15743157 2004
53
Inhibition of thrombin generation by protein S at low procoagulant stimuli: implications for maintenance of the hemostatic balance. 54 61
15292065 2004
54
Co-segregation of the PROS1 locus and protein S deficiency in families having no detectable mutations in PROS1. 54 61
15550022 2004
55
Prevalence of factor V Leiden mutation and other hereditary thrombophilic factors in Egyptian children with portal vein thrombosis: results of a single-center case-control study. 54 61
15309526 2004
56
Extended treatment for venous thromboembolism: how long is long enough? 54 61
15341706 2004
57
Risk factors and recurrence rate of primary deep vein thrombosis of the upper extremities. 54 61
15262837 2004
58
Predicting the risk of recurrence of venous thromboembolism. 54 61
15257020 2004
59
Low-molecular-weight heparin versus low-dose aspirin in women with one fetal loss and a constitutional thrombophilic disorder. 54 61
14739212 2004
60
Ischemic colitis revisited: a prospective study identifying hypercoagulability as a risk factor. 54 61
14982257 2004
61
HELLP syndrome, multifactorial thrombophilia and postpartum myocardial infarction. 54 61
15085897 2004
62
Warfarin skin necrosis associated with protein S deficiency and a mutation in the methylenetetrahydrofolate reductase gene. 54 61
14723717 2004
63
Pediatric venous thromboembolic disease in one single center: congenital prothrombotic disorders and the clinical outcome. 54 61
14675086 2003
64
Risk factors for venous thrombosis in the black population. 54 61
14597978 2003
65
[Definition of thrombophilia]. 54 61
15027578 2003
66
Symptomatic venous thromboembolism in Hong Kong Chinese children. 54 61
12904613 2003
67
Clinical and functional assessment after anticoagulant therapy of acute deep vein thrombosis involving the lower limb. 54 61
12950126 2003
68
Graves' disease associated with anticardiolipin antibody positivity and acquired protein S deficiency. 54 61
12856147 2003
69
Combination of congenital coagulation disorders: Factor II gene mutation G20210A, Factor V Leiden gene mutation G1691A and protein S deficiency. a family study. 54 61
12801853 2003
70
Prothrombotic conditions in an unselected cohort of children with venous thromboembolic disease. 54 61
12871356 2003
71
Role of the geneticist in testing and counseling for inherited thrombophilia. 54 61
12792420 2003
72
Deep venous thrombosis associated with factor V Leiden, G20210A mutation, and protein S deficiency. 54 61
12714139 2003
73
Coagulation factor content of solvent/detergent plasma compared with fresh frozen plasma. 54 61
12695752 2003
74
Prothrombin G20210A mutation and oral contraceptive use increase upper-extremity deep vein thrombotic risk. 54 61
12624627 2003
75
Factor V Leiden mutation in Sneddon syndrome. 54 61
12765305 2003
76
[Genetic risk factors of venous thromboembolism]. 54 61
15100907 2003
77
Severe protein S deficiency associated with heterozygous factor V Leiden mutation in a child with purpura fulminans. 54 61
12687747 2003
78
Mid-trimester severe intrauterine growth restriction is associated with a high prevalence of thrombophilia. 54 61
12504973 2002
79
Deep vein thrombosis is not rare in Asia--the Singapore General Hospital experience. 54 61
12520831 2002
80
The clinical spectrum of acute renal infarction. 54 61
12389340 2002
81
Prevalence of inherited thrombophilia in young thrombosis patients from the East Bohemian region. 54 61
12192310 2002
82
Metabolic characteristics of women who developed ovarian hyperstimulation syndrome. 54 61
12151426 2002
83
Combined genetic defects in a child with ischemic stroke: case report. 54 61
12269733 2002
84
Cutaneous necrosis revealing the coexistence of an antiphospholipid syndrome with acquired protein S deficiency, factor V Leiden and hyperhomocysteinemia. 54 61
11978573 2002
85
Third-trimester unexplained intrauterine fetal death is associated with inherited thrombophilia. 54 61
11978272 2002
86
An evaluation of screening tests for defects in the protein C pathway: commercial kits lack sensitivity and specificity. 54 61
11914658 2002
87
How strong is the association between maternal thrombophilia and adverse pregnancy outcome? A systematic review. 54 61
11803092 2002
88
Hematological risk factors for coronary heart disease. 54 61
12444311 2002
89
Idiopathic osteonecrosis in an adult with familial protein S deficiency and hyperhomocysteinemia. 54 61
11685042 2001
90
Thrombophilia and pregnancy: review of the literature and some original data. 54 61
11697706 2001
91
Thrombophilic factors in chronic thromboembolic pulmonary hypertension. 54 61
11555695 2001
92
Internal jugular vein thrombosis following in-vitro fertilization in a woman with protein S deficiency and heterozygosity for the prothrombin 3' UTR mutation, despite anticoagulation with heparin. 54 61
11555702 2001
93
Inherited thrombophilia in ischemic stroke and its pathogenic subtypes. 54 61
11486107 2001
94
Warfarin-induced skin necrosis associated with Factor V Leiden and protein S deficiency. 54 61
11683790 2001
95
[Thrombophilia factors as inducers of retinal vascular occlusion]. 54 61
11450475 2001
96
The risk of recurrent venous thromboembolism among heterozygous carriers of the G20210A prothrombin gene mutation. 54 61
11380448 2001
97
Hypercoagulability states in upper-extremity deep venous thrombosis. 54 61
11279652 2001
98
Primary thrombophilia in Mexico. II. Factor V G1691A (Leiden), prothrombin G20210A, and methylenetetrahydrofolate reductase C677T polymorphism in thrombophilic Mexican mestizos. 54 61
11426488 2001
99
[Frequency of antiphospholipid antibodies and Leiden mutation of hemostasis Factor V in unexplained recurrent fetal and embryo loss]. 54 61
11785358 2001
100
The A20210 allele in the prothrombin gene enhances the risk of venous thrombosis in carriers of inherited protein S deficiency. 54 61
10847418 2000
101
Flow cytometric analysis of autonomous growth of erythroid precursors in liquid culture detects occult polycythemia vera in the Budd-Chiari syndrome. 54 61
10782905 2000
102
Genetic analysis, phenotypic diagnosis, and risk of venous thrombosis in families with inherited deficiencies of protein S. 54 61
10706858 2000
103
Higher risk of venous thrombosis during early use of oral contraceptives in women with inherited clotting defects. 54 61
10632304 2000
104
Management of patients with hereditary hypercoagulable disorders. 54 61
10774459 2000
105
The molecular basis of inherited thrombophilia. 54 61
10938925 2000
106
Prothrombotic abnormalities in children with venous thromboembolism. 54 61
10695825 2000
107
Evaluation of a highly specific functional test for the detection of factor V Leiden. 54 61
11196068 2000
108
Heritable coagulopathies in pregnancy. 54 61
10596396 1999
109
Coinheritance of the HR2 haplotype in the factor V gene confers an increased risk of venous thromboembolism to carriers of factor V R506Q (factor V Leiden). 54 61
10556190 1999
110
Acquired protein S deficiency caused by estrogen treatment of tall stature. 54 61
10518082 1999
111
Case-control study of the frequency of thrombophilic disorders in couples with late foetal loss and no thrombotic antecedent--the Nîmes Obstetricians and Haematologists Study5 (NOHA5). 54 61
10404763 1999
112
Risk of venous thromboembolism and clinical manifestations in carriers of antithrombin, protein C, protein S deficiency, or activated protein C resistance: a multicenter collaborative family study. 54 61
10195932 1999
113
Protein S deficiency, activated protein C resistance and sticky platelet syndrome in a young woman with bilateral strokes. 54 61
9973658 1999
114
Factor V Leiden and antibodies against phospholipids and protein S in a young woman with recurrent thromboses and abortion. 54 61
10091395 1999
115
Varicella purpura fulminans associated with heterozygosity for factor V leiden and transient protein S deficiency. 54 61
9794956 1998
116
Association between acquired free protein S deficiency, anticardiolipin antibodies, and thrombotic events in rheumatoid arthritis. 54 61
9818679 1998
117
Genetic abnormalities of the protein C system: shared risk factors in young adults with migraine with aura and with ischemic stroke? 54 61
9876885 1998
118
Different risks of thrombosis in four coagulation defects associated with inherited thrombophilia: a study of 150 families. 54 61
9746774 1998
119
Inherited prothrombotic states and ischaemic stroke in childhood. 54 61
9771774 1998
120
[Potential role of primary hypercoagulability and antiphospholipid antibody as a risk factor of acute pulmonary thromboembolism]. 54 61
9833233 1998
121
[Thrombophilic states]. 54 61
10358455 1998
122
No correlation between activated protein C resistance and free flap failures in 100 consecutive patients. 54 61
9623826 1998
123
A novel mutation in intron K of the PROS1 gene causes aberrant RNA splicing and is a common cause of protein S deficiency in a UK thrombophilia cohort. 54 61
9657428 1998
124
Severe preeclampsia associated with coinheritance of factor V Leiden mutation and protein S deficiency. 54 61
9572171 1998
125
Inherited thrombophilia and pregnancy. 54 61
9551309 1998
126
A common 4G allele in the promoter of the plasminogen activator inhibitor-1 (PAI-1) gene as a risk factor for pulmonary embolism and arterial thrombosis in hereditary protein S deficiency. 54 61
9569196 1998
127
Early loss of renal transplants in patients with thrombophilia. 54 61
9565098 1998
128
[Combined hemostatic defects in family members of symptomatic carriers of Leiden mutations of factor V]. 54 61
9760807 1998
129
Factor V Leiden and genetic defects of thrombophilia in childhood porencephaly. 54 61
9577282 1998
130
Coexistence of primary antiphospholipid syndrome and protein S deficiency in a Hispanic man with ischemic stroke. 54 61
9521377 1998
131
Protein S deficiency and factor V Leiden gene in pregnancy. 54 61
15512044 1998
132
Clinical features of thrombophilia in families with gene defects in protein C or protein S combined with factor V Leiden. 54 61
9607123 1998
133
Coagulation disorders in young adults with acute cerebral ischaemia. 54 61
9457624 1998
134
Co-inheritance of the 20210A allele of the prothrombin gene increases the risk of thrombosis in subjects with familial thrombophilia. 54 61
9423788 1997
135
A hitherto unknown splice site defect in the protein S gene (PROS1): the mutation results in allelic exclusion and causes type I and type III protein S deficiency. 54 61
9375743 1997
136
A novel thrombomodulin gene mutation in a patient suffering from sagittal sinus thrombosis. 54 61
9364978 1997
137
Recurrence of venous thromboembolism in patients with familial thrombophilia. 54 61
9342999 1997
138
Identification of two different mutations causing protein S deficiency in two unrelated Belgian families using a nonisotopic scanning and sequencing method. 54 61
9690481 1997
139
High prevalence of antithrombin III, protein C and protein S deficiency, but no factor V Leiden mutation in venous thrombophilic Chinese patients in Taiwan. 54 61
9271815 1997
140
Leiden factor V mutation in four patients with small bowel infarctions. 54 61
9207293 1997
141
Resistance to activated protein C in unselected patients with arterial and venous thrombosis. 54 61
9208999 1997
142
Purpura fulminans induced by disseminated intravascular coagulation following infection in 2 unrelated children with double heterozygosity for factor V Leiden and protein S deficiency. 54 61
9241737 1997
143
Resistance to activated protein C and factor V Leiden. 54 61
9205675 1997
144
Causes and outcome of deep-vein thrombosis in otherwise-healthy patients under 50 years. 54 61
9307763 1997
145
Absence of linkage between type III protein S deficiency and the PROS1 and C4BP genes in families carrying the protein S Heerlen allele. 54 61
9108398 1997
146
Laboratory evaluation and clinical characteristics of 2,132 consecutive unselected patients with venous thromboembolism--results of the Spanish Multicentric Study on Thrombophilia (EMET-Study). 54 61
9065991 1997
147
Thrombophilia in ethnic Arabs in Kuwait. 54 61
9003158 1996
148
Identification of 19 protein S gene mutations in patients with phenotypic protein S deficiency and thrombosis. Protein S Study Group. 54 61
8943854 1996
149
Coagulation studies, factor V Leiden, and anticardiolipin antibodies in 40 cases of cerebral venous thrombosis. 54 61
8841318 1996
150
Molecular basis of protein S deficiency in three families also showing independent inheritance of factor V leiden. 54 61
8781426 1996
151
Factor V Q 506 mutation in children with thrombosis. 54 61
8813095 1996
152
Two new frequent dimorphisms in the protein S (PROS1) gene. 54 61
8883276 1996
153
Factor V enhances the cofactor function of protein S in the APC-mediated inactivation of factor VIII: influence of the factor VR506Q mutation. 54 61
8865533 1996
154
Reversible cardiogenic shock in an angry woman--case report and review of the literature. 54 61
8689541 1996
155
First case of sporadic protein S deficiency due to a novel candidate mutation, Ala 484-->Pro, in the protein S active gene (PROS1). 54 61
8822580 1996
156
Cerebral and vein thrombosis, transient protein S deficiency, and anticardiolipin antibodies. 54 61
8638627 1996
157
Characterization of a large chromosomal deletion in the PROS1 gene of a patient with protein S deficiency type I using long PCR. 54 61
8616098 1996
158
Elevated levels of prothrombin activation fragment 1 + 2 in plasma from patients with heterozygous Arg506 to Gln mutation in the factor V gene (APC-resistance) and/or inherited protein S deficiency. 54 61
8815575 1996
159
Resistance to activated protein C as pathogenic factor of venous thromboembolism. 54 61
9108706 1996
160
Endothelial dysfunction in preeclampsia. Part II: Reducing the adverse consequences of endothelial cell dysfunction in preeclampsia; therapeutic perspectives. 54 61
8773939 1996
161
Familial thrombophilia: clinical and molecular analysis of Swedish families with inherited resistance to activated protein C or protein S deficiency. 54 61
8981666 1996
162
Underlying disorders associated with severe early-onset preeclampsia. 54 61
7485291 1995
163
Childhood thrombosis. 54 61
7630687 1995
164
Resistance to activated protein C as an additional genetic risk factor in hereditary deficiency of protein S. 54 61
7780138 1995
165
Inherited resistance to activated protein C in a boy with multiple thromboses in early infancy. 54 61
7607278 1995
166
Blood protein defects associated with thrombosis. Laboratory assessment. 54 61
7781275 1995
167
Anticardiolipin antibodies, functional protein S deficiency, and fetal loss. 54 61
7832202 1995
168
Anticardiolipin and acquired protein S deficiency in early childhood. 54 61
7946553 1994
169
Hypercoagulability and thrombosis. 54 61
8170263 1994
170
Three novel mutations in five unrelated subjects with hereditary protein S deficiency type I. 54 61
8113388 1994
171
Protein S Tokushima: abnormal molecule with a substitution of Glu for Lys-155 in the second epidermal growth factor-like domain of protein S. 54 61
8298131 1994
172
Syndromes of hypercoagulability and thrombosis: a review. 54 61
8059229 1994
173
Association of protein S deficiency with thrombosis in a kindred with increased levels of plasminogen activator inhibitor-1. 54 61
8379599 1993
174
Hypercoagulable states. 54 61
8379603 1993
175
Anticoagulant protein C pathway defective in majority of thrombophilic patients. 54 61
8400251 1993
176
Ischemic stroke due to deficiency of coagulation inhibitors. Report of 10 young adults. 54 61
8418545 1993
177
Acquired antithrombin III deficiency: replacement with antithrombin III concentrates in a patient with protein S deficiency accelerates response to therapy. 54 61
8291376 1993
178
[Hemostasis profiles in thrombotic disease]. 54 61
1788455 1991
179
Transient anticardiolipin antibodies, functional protein S deficiency, and deep vein thrombosis. 54 61
1825446 1991
180
[Congenital deficiencies of natural anticoagulant systems responsible for recurrent thromboembolism]. 54 61
1828303 1991
181
Compound heterozygous mutations identified in severe type I protein S deficiency impaired the secretion of protein S. 61
31422373 2020
182
Ischemic Stroke with Protein S Deficiency Treated by Apixaban. 61
31941580 2020
183
Cerebral venous sinus thrombosis associated with protein S deficiency during pregnancy: a case report. 61
31475594 2020
184
Spiny keratoderma: Report of three cases. 61
31860150 2019
185
Reconstructive complications of thrombophilia and keloid scarring: free flap surgery in a patient with mild protein S deficiency. 61
31629548 2019
186
Risk factors for venous thromboembolism (VTE) recurrences in Thai patients without cancer. 61
30334695 2019
187
Peripartum myocardial infarction associated with coronary spasm and acquired protein S deficiency: A case report. 61
31770234 2019
188
A novel mutation Gly222Arg in PROS1 causing protein S deficiency in a patient with pulmonary embolism. 61
31743498 2019
189
Risk Factors and Outcomes of Recurrent Pregnancy Loss in Japan. 61
31397532 2019
190
Inherited Thrombophilia and the Risk of Arterial Ischemic Stroke: A Systematic Review and Meta-Analysis. 61
31549567 2019
191
Revascularization for Cerebral Ischemia, Step-by-Step Demonstration of Bonnet Bypass: 3-Dimensional Operative Video. 61
30690494 2019
192
Successful endovascular recanalization of massive cerebral venous sinus thrombosis in a patient with tuberous sclerosis and protein S deficiency: a case report. 61
31312460 2019
193
Perioperative management of laparoscopic surgery in a patient with protein S deficiency complications: A case report. 61
30259674 2019
194
Spontaneous skin necrosis revealing protein S deficiency in Crohn's disease. 61
31213302 2019
195
Protein S deficiency revealed by skin necrosis in a patient with lupus. 61
31018760 2019
196
Venous Thromboembolism in a Young Girl with Duplication of the Inferior Vena Cava and Protein S Deficiency 61
30651208 2019
197
Bilateral Abducens Nerve Palsy Due to Extensive Cerebral Venous Sinus Thrombosis. 61
31018594 2019
198
Acute Myocardial Infarction as an Initial Presentation of Protein C and Protein S Deficiency Followed by Dilated Cardiomyopathy in a Young Male. 61
31259110 2019
199
New functional test for the TFPIα cofactor activity of Protein S working in synergy with FV-Short. 61
30740865 2019
200
Clinical Manifestation and Mutation Spectrum of 53 Unrelated Pedigrees with Protein S Deficiency in China. 61
30669159 2019
201
Mixed cerebrovascular disease in an elderly patient with mixed vascular risk factors: a case report. 61
30755166 2019
202
PROS1 IVS10+5G>A mutation causes hereditary protein S deficiency in a Chinese patient with pulmonary embolism and venous thromboembolism. 61
30543986 2019
203
Recurrent strokes, central nervous system vasculitis, and acquired protein S deficiency secondary to varicella zoster in a child with AIDS. 61
30478796 2019
204
Aortic Mural Thrombus in the Non-atherosclerotic Aorta of Patients with Multiple Hypercoagulable Factors. 61
30210102 2019
205
[Exhaustive analysis of genetic mutations associated with protein S deficiency utilizing next-generation sequencing analysis]. 61
31068512 2019
206
Arterial Ischemic Stroke in a Child with Internal Carotid Artery Hypoplasia and Protein S Deficiency. 61
31316645 2019
207
Acquired Protein S Deficiency in a Patient with Lupus Nephritis. 61
30787859 2019
208
Cerebral Venous Thrombosis and Acute Pulmonary Embolism following Varicella Infection. 61
31742195 2019
209
Recurrent venous thrombosis during direct oral anticoagulant therapy in a patient with protein S deficiency. 61
31064935 2019
210
Myocardial infarction in a pregnant woman revealing a transitional deficit in protein S: a rare case report. 61
31762895 2019
211
Direct Oral Anticoagulants in Patients Affected by Major Congenital Thrombophilia. 61
31308920 2019
212
Thrombophilic risk factors in hemodialysis: Association with early vascular access occlusion and patient survival in long-term follow-up. 61
31539375 2019
213
Recurrent esophagogastric variceal bleeding due to portal vein thrombosis caused by protein S deficiency. 61
30410946 2018
214
Double versus single thrombophilias during pregnancy. 61
28670948 2018
215
Nontraumatic Compartment Syndrome in a Patient with Protein S Deficiency: A Case Report. 61
30601765 2018
216
[Ascites as first manifestation of superior mesenteric and portal vein thrombosis secondary to protein S deficiency]. 61
29439833 2018
217
Non-genetic and genetic risk factors for adult cerebral venous thrombosis. 61
30005273 2018
218
Prothrombotic markers in Thalassemia major patients: A paradigm shift. 61
30121679 2018
219
Protein S deficiency in patients from the French Basque Country with various thrombotic conditions: a rarer inherited trait in autochthonous individuals? 61
29802506 2018
220
Warfarin-induced skin necrosis in a patient with protein S deficiency. 61
30066782 2018
221
Extensive Necrotic Skin Lesions Due to Post-varicella Protein S Deficiency. 61
29341982 2018
222
Recurrent pulmonary embolism associated with deep venous thrombosis diagnosed as protein s deficiency owing to a novel mutation in PROS1: A case report. 61
29742732 2018
223
The relationship between the levels and function of endothelial progenitor cells and factor V Leiden and protein C deficiency in patients with primary Budd-Chiari syndrome. 61
29771426 2018
224
Adverse pregnancy outcomes and inherited thrombophilia. 61
28792912 2018
225
Vitamin K-Dependent Protein S: Beyond the Protein C Pathway. 61
28905350 2018
226
[Spontaneous neonatal aortic thrombosis revealing protein S deficiency]. 61
29425542 2018
227
Rivaroxaban Treatment for Warfarin-Refractory Thrombosis in a Patient with Hereditary Protein S Deficiency. 61
29607227 2018
228
Preventative management against thromboembolism using fresh frozen plasma in a coronary artery bypass graft patient with protein S deficiency: a case report. 61
29492451 2018
229
Rivaroxaban Causes Missed Diagnosis of Protein S Deficiency but Not of Activated Protein C Resistance (Factor V Leiden). 61
28920711 2018
230
Coexistent Ipsilateral Internal Carotid Artery Occlusion and Cerebral Venous Thrombosis in Hepatitis C. 61
29349091 2018
231
The Prevalence of Thrombophilia in Women With Recurrent Fetal Loss and Outcome of Anticoagulation Therapy for the Prevention of Miscarriages. 61
27799457 2018
232
Umbilical Artery Thrombosis with Associated Acute and Severe Fetal Growth Restriction and Transient Severe Protein S Deficiency: Report of a Case with Prenatal Ultrasound Diagnosis Allowing for Timely Intervention and Good Outcome. 61
30112236 2018
233
Preliminary Data From the Study of Coagulative Profile of HIV Infected Individuals Suggest a Role For Point Mutations in the Gene in Protein S Deficiency in Individuals Undergoing Highly Antiretroviral Therapy. 61
29576814 2018
234
Asymptomatic Isolated Calf Deep Vein Thrombosis: Does It Worsen after Varicose Vein Surgery? 61
29515697 2017
235
Venous thromboembolism associated with protein S deficiency due to Arg451* mutation in PROS1 gene: a case report and a literature review. 61
29321366 2017
236
Successful medical management of acute mesenteric ischemia due to superior mesenteric and portal vein thrombosis in a 27-year-old man with protein S deficiency: a case report. 61
29117862 2017
237
Pregnancy, thrombophilia, and the risk of a first venous thrombosis: systematic review and bayesian meta-analysis. 61
29074563 2017
238
Thrombophilic and cardiovascular risk factors for retinal vein occlusion. 61
28684050 2017
239
Birthweight in pregnant women with protein S deficiency treated with low-molecular-weight heparin: a retrospective cohort study. 61
27677928 2017
240
Non-vitamin K antagonist oral anticoagulants in patients with severe inherited thrombophilia: a series of 33 patients. 61
28079536 2017
241
An Unexpectedly High Rate of Thrombophilia Disorders in Patients with Superficial Vein Thrombosis of the Lower Extremities. 61
28501666 2017
242
Lupus protein-losing enteropathy patient with protein C and protein S deficiency-induced thrombosis: A case report with review of the literature. 61
28375198 2017
243
Native aortic valve thrombosis in patient with protein S deficiency. 61
28419228 2017
244
Identification of reference miRNAs in plasma useful for the study of oestrogen-responsive miRNAs associated with acquired Protein S deficiency in pregnancy. 61
28743297 2017
245
Pulmonary embolism and in situ pulmonary artery thrombosis in paediatrics. A systematic review. 61
28331932 2017
246
Clinical outcomes and a high prevalence of abnormalities on comprehensive arterial and venous thrombophilia screening in TIA or ischaemic stroke patients with a patent foramen ovale, an inter-atrial septal aneurysm or both. 61
28477701 2017
247
Genotypes and phenotypes of protein S deficiency in Thai children with thromboembolism. 61
27748013 2017
248
HIV infection, hypercoagulability and ischaemic stroke in adults at the University Teaching Hospital in Zambia: a case control study. 61
28521833 2017
249
New functional assays to selectively quantify the activated protein C- and tissue factor pathway inhibitor-cofactor activities of protein S in plasma. 61
28211163 2017
250
High prevalence of mental disorders in patients with inherited protein S deficiency: A case report series. 61
28189910 2017
251
Associations between pre-eclampsia and protein C and protein S levels among pregnant Nigerian women. 61
28092096 2017
252
Cerebral venous thrombosis at high altitude: A systematic review. 61
28038774 2017
253
Plasma hypercoagulability in the presence of thrombomodulin but not of activated protein C in patients with cirrhosis. 61
27421039 2017
254
Gene analysis of six cases of congenital protein S deficiency and functional analysis of protein S mutations (A139V, C449F, R451Q, C475F, A525V and D599TfsTer13). 61
28088608 2017
255
Genetic Risk Factors of Venous Thromboembolism in the East Algerian Population. 61
26304686 2017
256
Livedoid vasculopathy and popliteal artery occlusion in a patient with protein S deficiency. 61
27774697 2017
257
[Non-cirrhotic portal hypertension due to didanosina. A rare case]. 61
28489843 2017
258
The prevalence and clinical manifestation of hereditary thrombophilia in Korean patients with unprovoked venous thromboembolisms. 61
29040284 2017
259
The use of direct oral anticoagulants in inherited thrombophilia. 61
27734187 2017
260
Dangerous Headache: A Case of Dural Venous Sinus Thrombosis with Protein S Deficiency. 61
28274079 2017
261
Thrombogenesis in Thrombophilic Pregnancy: Evaluation of Low-Molecular-Weight Heparin Prophylaxis. 61
28478442 2017
262
A novel PROS1 mutation, c.74dupA, was identified in a protein S deficiency family. 61
27846449 2016
263
Acquired protein S deficiency manifests as pulmonary embolism in early pregnancy: a case report. 61
27595759 2016
264
Hereditary risk factors for thrombophilia and probability of venous thromboembolism during pregnancy and the puerperium. 61
27613196 2016
265
Thrombin generation and cell-dependent hypercoagulability in sickle cell disease. 61
27430959 2016
266
Etiology of Recurrent Pregnancy Loss in Saudi Females. 61
30787727 2016
267
[Pedigree survey in a family with hereditary protein S deficiency]. 61
27667277 2016
268
Influenza-associated thrombotic microangiopathy with unbalanced von Willebrand factor and a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 levels in a heterozygous protein S-deficient boy. 61
27435311 2016
269
Protein S deficiency complicated pregnancy in women with recurrent pregnancy loss. 61
26941215 2016
270
Oral tranexamic acid (TA) in the treatment of melasma: A retrospective analysis. 61
27206758 2016
271
Protein S testing in patients with protein S deficiency, factor V Leiden, and rivaroxaban by North American Specialized Coagulation Laboratories. 61
27075008 2016
272
Combined oral contraceptives, thrombophilia and the risk of venous thromboembolism: a systematic review and meta-analysis. 61
27121914 2016
273
Evaluation of cases with cerebral thrombosis in children. 61
27489465 2016
274
Retiform Purpura Associated With Protein S Deficiency. 61
26708564 2016
275
Thrombophilia in Korean patients with arterial or venous thromboembolisms. 61
27274510 2016
276
Successful penile reconstruction following prior arteriovenous loop thrombosis due to undiagnosed protein-S deficiency and exogenous testosterone. 61
27833295 2016
277
A Case of Postinfectious Protein S Deficiency Masquerading as Henoch-Schönlein Purpura. 61
26063758 2016
278
Malignant isolated cortical vein thrombosis with type II protein S deficiency: a case report. 61
27193638 2016
279
Intraventricular Hemorrhage in a Term Neonate: Manifestation of Protein S Deficiency- A Case Report. 61
27252923 2016
280
Ertapenem-Induced Acute Interstitial Nephritis (AIN) in a Case of Protein S Deficiency and Factor V Leiden Mutation with Deep Vein Thrombosis. 61
27731567 2016
281
Endothelial Nitric Oxide Synthase T-786C Mutation, Prothrombin Gene Mutation (G-20210-A) and Protein S Deficiency Could Lead to Myocardial Infarction in a Very Young Male Adult. 61
27275349 2016
282
PROS1 genotype phenotype relationships in a large cohort of adults with suspicion of inherited quantitative protein S deficiency. 61
26466767 2016
283
Impact of Obliterative Portal Venopathy Associated With Human Immunodeficiency Virus. 61
26986141 2016
284
Antithrombotic prophylaxis in a patient with nephrotic syndrome and congenital protein S deficiency. 61
26928822 2016
285
Thrombin generation and other coagulation parameters in a patient with homozygous congenital protein S deficiency on treatment with rivaroxaban. 61
26586461 2016
286
Low-molecular-weight-heparin can benefit women with recurrent pregnancy loss and sole protein S deficiency: a historical control cohort study from Taiwan. 61
27799851 2016
287
Dysfunction in the coagulation system and schizophrenia. 61
26731441 2016
288
Inherited thrombophilia and reproductive disorders. 61
27026779 2016
289
Identifying the Bariatric Patient at Risk for Pulmonary Embolism: Prospective Clinical Trial Using Duplex Sonography and Blood Screening. 61
25808796 2015
290
Associations between phenotypes of preeclampsia and thrombophilia. 61
26444331 2015
291
[Bilateral simultaneous central retinal vein occlusion in protein S deficiency]. 61
25666570 2015
292
Intrapartum temporary inferior vena cava filters are rarely indicated in pregnant women with deep venous thromboses. 61
26992613 2015
293
Evaluation of Some Plasma Coagulation Factors in Women with Spontaneous Miscarriage. 61
26644853 2015
294
Inherited and acquired thrombophilia in Indian women experiencing unexplained recurrent pregnancy loss. 61
26227844 2015
295
Hereditary protein S deficiency leads to ischemic stroke. 61
25997409 2015
296
Systemic Lupus Erythematosus with Deep Vein Thrombosis and Cutaneous Ulcer. 61
27608879 2015
297
Thrombophilia Profile in Budd-Chiari Syndrome and Splanchnic Vein Thrombosis: A Study from Western India. 61
27608864 2015
298
Thrombophilia diagnosis: a retrospective analysis of a single-center experience. 61
26083989 2015
299
Cerebral Venous Thrombosis, Protein S Deficiency and Pregnancy Triad:A Case Report. 61
28276047 2015
300
Haemostatic and fibrinolytic changes in obese subjects undergoing bariatric surgery: the effect of different surgical procedures. 61
25545872 2015
301
Neonatal arterial thromboembolism and limb loss following respiratory distress syndrome: Case report. 61
25996336 2015
302
Late onset thrombosis in two Japanese patients with compound heterozygote protein S deficiency. 61
25868595 2015
303
Cutaneous manifestations in antiphospholipid syndrome. 61
25875603 2015
304
Thrombophilic risk factors are uncommon in young patients with retinal vein occlusion. 61
25299970 2015
305
Protein S deficiency present in a pregnant woman with dyspnea, abdominal pains, restlessness, agitation and hypofibrinogenemia. 61
25914811 2015
306
Testosterone therapy, thrombophilia, and hospitalization for deep venous thrombosis-pulmonary embolus, an exploratory, hypothesis-generating study. 61
25648660 2015
307
Cerebral venous thrombosis in young adult with familial protein S deficiency. 61
25304012 2015
308
Pharmacomechanical thrombectomy and catheter-directed thrombolysis of acute lower extremity deep venous thrombosis in a 9-year-old boy with inferior vena cava atresia. 61
25480759 2015
309
A novel nonsense mutation Tyr301* of PROS1 causing protein S deficiency. 61
25255242 2015
310
Central retinal vein occlusion as a presenting feature in a young patient with protein S deficiency. 61
25331213 2015
311
Role of protein S deficiency in children with venous thromboembolism. An observational international cohort study. 61
25272994 2015
312
Recurrent Postoperative Spinal Epidural Hematoma in a Patient with Protein S Deficiency. 61
26236521 2015
313
Stent thrombosis caused by metal allergy complicated by protein S deficiency and heparin-induced thrombocytopenia: a case report and review of the literature. 61
26207097 2015
314
Inherited risk factors in low-risk venous thromboembolism in patients under 45 years. 61
25326427 2015
315
Acute ST Elevated Myocardial Injury due to Coronary Thrombosis during Thoracic Endovascular Aortic Repair in Patient with Protein S Deficiency. 61
25469146 2014
316
Venous thromboembolism at uncommon sites in neonates and children. 61
24517966 2014
317
Markers of low activity of tissue plasminogen activator/plasmin are prevalent in schizophrenia patients. 61
25205258 2014
318
No impact of endogenous prothrombotic conditions on the risk of central venous line-related thrombotic events in children: results of the KIDCAT study (KIDs with Catheter Associated Thrombosis). 61
25131188 2014
319
Stroke in young with primary protein--S deficiency. 61
25906532 2014
320
Skin necrosis complicated by warfarin-induced protein S deficiency. 61
25240306 2014
321
Rapidly progressive cognitive impairment in a patient with high flow dural arteriovenous fistulas, cerebral sinus thrombosis and protein S deficiency. 61
24736194 2014
322
The genomic architecture of the PROS1 gene underlying large tandem duplication mutation that causes thrombophilia from hereditary protein S deficiency. 61
24992033 2014
323
[Anesthetic management of cesarean section in a patient with pulmonary embolism due to protein S deficiency]. 61
25199326 2014
324
[Portal-splenic-mesenteric venous thrombosis in a patients with protein S deficiency due to novel PROS1 gene mutation]. 61
25168054 2014
325
Asymptomatic type B right atrial thrombus in a case with protein S deficiency. 61
24994736 2014
326
Coronary artery bypass grafting in a patient with protein S deficiency: perioperative implications. 61
24994735 2014
327
Protein S deficiency and novel oral anticoagulants: an intriguing case. 61
24642006 2014
328
PROS1 mutations associated with protein S deficiency in Polish patients with residual vein obstruction on rivaroxaban therapy. 61
24507871 2014
329
Multiple abdominal veins thrombosis secondary to protein s deficiency - a case report. 61
25121018 2014
330
Protein S Deficiency and an Adult Case with Moyamoya Syndrome that Presented with Primary Intraventricular Haemorrhage. 61
25207193 2014
331
Frequency of hereditary thrombophilia in women with recurrent pregnancy loss in Northern Pakistan. 61
24888916 2014
332
Biventricular thrombosis in a structurally normal heart at high altitude. 61
24879736 2014
333
Coronary artery bypass grafting in 2 thrombophilic patients with protein s deficiency. 61
25611767 2014
334
Left ventricular "masses" in a patient with protein S deficiency and a recent myocardial infarction: evidence of intraventricular thrombi or a benign observation? 61
24011912 2014
335
Editorial comment: "coronary artery bypass grafting in 2 thrombophilic patients with protein s deficiency" and "fulminant intraoperative right heart and pulmonary artery thrombosis following prothrombin complex concentrate infusion after complex open heart surgery with cardiopulmonary bypass". 61
25611768 2014
336
Association between prothrombin gene polymorphisms and hereditary thrombophilia in Xinjiang Kazakhs population. 61
24162564 2014
337
Distinct frequencies and mutation spectrums of genetic thrombophilia in Korea in comparison with other Asian countries both in patients with thromboembolism and in the general population. 61
24162787 2014
338
Staphylococcal endocarditis as the first manifestation of heritable protein S deficiency in childhood. 61
24462440 2014
339
Successful management of acute mesenteric ischaemia in a pregnant woman with protein S deficiency. 61
24652435 2014
340
[Pregnancy outcome and thrombophilia of women with recurrent fetal death]. 61
24676012 2014
341
Sepsis Causing Acquired Protein C and Protein S Deficiency. 61
26905558 2014
342
Heerlen polymorphism associated with type III protein S deficiency and factor V Leiden mutation in a Polish patient with deep vein thrombosis. 61
24365770 2014
343
Acquired pial and dural arteriovenous fistulae following superior sagittal sinus thrombosis in patients with protein S deficiency: a report of two cases. 61
24162240 2014
344
Review of Management and Outcomes in Women with Thrombophilia Risk during Pregnancy at a Single Institution. 61
24693443 2014
345
Skin necrosis: a rare complication of protein S deficiency. 61
24600778 2014
346
Inherited thrombophilia and recurrent pregnancy loss. 61
24693393 2013
347
Anticoagulant treatment with rivaroxaban in severe protein S deficiency. 61
24144709 2013
348
Splenic infarction in a child with primary Epstein-Barr virus infection. 61
24134766 2013
349
Protein S levels and the risk of venous thrombosis: results from the MEGA case-control study. 61
24014240 2013
350
Thrombophilia differences in splanchnic vein thrombosis and lower extremity deep venous thrombosis in North America. 61
23247829 2013
351
Molecular basis of protein S deficiency in China. 61
23813890 2013
352
Protein C and protein S deficiency presenting as Budd-Chiari syndrome. 61
23751604 2013
353
Mycoplasma pneumoniae associated stroke in a 3-year-old girl. 61
24223604 2013
354
[Two cases of pulmonary thromboembolism associated with protein C and protein S deficiency and literature review]. 61
24071697 2013
355
Distal subclavian artery occlusion causing multiple cerebral infarcts consequence of retrograde flow of a thrombus? 61
24167803 2013
356
Decreased tissue factor pathway inhibitor (TFPI)-dependent anticoagulant capacity in patients with cirrhosis who have decreased protein S but normal TFPI plasma levels. 61
23841464 2013
357
An odd application of artificial vascular graft in the kidney transplantation of a patient with severe deep vein thrombosis: a case report. 61
24034057 2013
358
[Recurring arterial reocclusion following endovascular recanalisation in a patient with protein S deficiency]. 61
23799601 2013
359
Protein C and protein S deficiency - practical diagnostic issues. 61
23986205 2013
360
Hereditary thrombophilia in cerebral venous thrombosis: a study from India. 61
23518830 2013
361
Long-term Outcome of Budd-Chiari Syndrome: A Single Center Experience. 61
24829685 2013
362
Thyroid storm presenting as congestive heart failure and protein-S deficiency-induced biventricular and internal jugular venous thrombii. 61
24029205 2013
363
Prediction of ischemic stroke in young Indians: is thrombophilia profiling a way out? 61
23337710 2013
364
Omental gangrene and porto-mesenteric thrombosis in a patient of protein C and protein s deficiency. 61
24426632 2013
365
Prevalence of hereditary antithrombin mutations is higher than estimated in patients with thrombotic events. 61
23429250 2013
366
Cerebral sinodural thrombosis following minor head injury in children. 61
23394736 2013
367
PP045. Different associations between phenotypes of preeclampsia and thrombophilias. 61
26105900 2013
368
Reversible diencephalic dysfunction as presentation of deep cerebral venous thrombosis due to hyperhomocysteinemia and protein S deficiency: Documentation of a case. 61
23914104 2013
369
Association of hereditary thrombophilia with intrauterine growth restriction. 61
24639756 2013
370
Investigation of inherited thrombophilias in patients with pulmonary embolism. 61
23358198 2013
371
[Spontaneous miscarriages and congenital protein S deficiency: a case report]. 61
23587581 2013
372
Streptococcus agalactiae infective endocarditis with large vegetation in a patient with underlying protein S deficiency. 61
23001489 2013
373
[Association of celiac disease and cerebral venous thrombosis: report of two cases]. 61
23287617 2013
374
Deep vein thrombosis and pulmonary embolism in a child with diabetic ketoacidosis and protein s deficiency: a case report. 61
23306559 2013
375
The influence of thrombophilia on the long-term survival of patients with a history of venous thromboembolism. 61
23178976 2013
376
Females with subclavian vein thrombosis may have an increased risk of hypercoagulability. 61
23324841 2013
377
Coagulation disorders in patients with femoral head osteonecrosis. 61
24453643 2013
378
[Intravenous recombinant tissue plasminogen activator therapy in a 14-week pregnant woman with embolic stroke due to protein S deficiency]. 61
23524601 2013
379
Protein S deficiency and Heerlen polymorphism in a Polish patient with acute myocardial infarction and previous venous thromboembolism. 61
24119292 2013
380
Massive pulmonary embolism and thrombophilia. 61
23345503 2013
381
Venous thromboembolism in neonates and children--update 2013. 61
23452739 2013
382
Soluble thrombomodulin and endothelial cell protein C receptor levels in patients with cerebral venous and sinus thrombosis. 61
23899568 2013
383
Clinical and genetic features of protein C deficiency in 23 unrelated Chinese patients. 61
22951146 2013
384
Thrombophilia investigation in Pakistani women with recurrent pregnancy loss. 61
22690883 2013
385
Antiphospholipid syndrome presenting as pulmonary thrombosis and pancreatitis in a young man. 61
23235100 2012
386
[Thrombosis of the superior vena cava revealing a protein S deficiency]. 61
23164723 2012
387
TFPI resistance related to inherited or acquired protein S deficiency. 61
23079294 2012
388
Successful pregnancy outcome in a case of protein s deficiency. 61
24293862 2012
389
Factor V Leiden mutation is not a predisposing factor for acute coronary syndromes. 61
23253409 2012
390
Management of acute portomesenteric venous thrombosis induced by protein S deficiency: report of a case. 61
22484987 2012
391
Study of thrombophilia in recurrent pregnancy loss. 61
24082554 2012
392
Lateral sinus thrombosis and haemorrhagic ischemic stroke with protein S deficiency in a young. 61
24047030 2012
393
Venous thromboembolism in neonates and children. 61
22959549 2012
394
Association of thrombophilia and polycystic ovarian syndrome in women with history of recurrent pregnancy loss. 61
22452370 2012
395
Inherited thrombophilia in children with venous thromboembolism and the familial risk of thromboembolism: an observational study. 61
22581447 2012
396
Calciphylaxis induced by acquired protein S deficiency in a patient with multiple myeloma - effective treatment with low-molecular-weight heparin. 61
22551348 2012
397
Early recanalisation of cerebral venous sinus thrombosis in an unusual case associated with severe protein S deficiency. 61
22847569 2012
398
Small and large PROS1 deletions but no other types of rearrangements detected in patients with protein S deficiency. 61
22627709 2012
399
Case of proximal calciphylaxis with protein S deficiency, successfully treated with multimodality therapy. 61
21972994 2012
400
Multivessel thromboembolism associated with dysfunction of protein s. 61
22837980 2012
401
Recurrent Deep Vein Thrombosis due to Thrombophilia. 61
22701135 2012
402
The role of hypercoagulability in the development of osteonecrosis of the femoral head. 61
22802985 2012
403
Sneddon syndrome associated with Protein S deficiency. 61
22565458 2012
404
Predicting the risk of venous thromboembolism recurrence. 61
22367958 2012
405
Retinal arterial occlusions in the young: systemic associations in Indian population. 61
22446902 2012
406
Risk factors, clinical profile, and long-term outcome of 428 patients of cerebral sinus venous thrombosis: insights from Nizam's Institute Venous Stroke Registry, Hyderabad (India). 61
22626695 2012
407
HIV infection presenting as cerebral venous sinus thrombosis. 61
21406317 2012
408
Levamisole-adulterated in cocaine causing agranulocytosis, vasculopathy, and acquired protein S deficiency. 61
21773730 2012
409
Inherited protein S deficiency due to a novel nonsense mutation in the PROS1 gene in the patient with recurrent vascular access thrombosis: A case report. 61
26889411 2012
410
[Skin necrosis during long-term fluindione treatment revealing protein C deficiency]. 61
22401685 2012
411
Protein S deficiency in a living liver donor. 61
22175543 2012
412
Genotype and laboratory and clinical phenotypes of protein s deficiency. 61
22261441 2012
413
Mortality and inherited thrombophilia: results from the European Prospective Cohort on Thrombophilia. 61
22128841 2012
414
Heterogeneous lengths of copy number mutations in human coagulopathy revealed by genome-wide high-density SNP array. 61
21993689 2012
415
Evaluation of coagulation and fibrinolytic parameters in adult onset GH deficiency and the effects of GH replacement therapy: a placebo controlled study. 61
22226996 2012
416
Maternal serum protein S forms in pregnancies complicated by intrauterine growth restriction. 61
22104477 2012
417
Isolated protein S deficiency presenting as catastrophic systemic arterial and subsequently venous thrombosis. 61
23024716 2012
418
Low-molecular-weight heparin added to aspirin in the prevention of recurrent early-onset pre-eclampsia in women with inheritable thrombophilia: the FRUIT-RCT. 61
22118560 2012
419
Thrombophilia and retinal vascular occlusion. 61
22969282 2012
420
Arterial ischemic stroke in an adolescent with presumed perinatal ischemic stroke. 61
21868371 2012
421
Inherited prothrombotic risk factors in children with first ischemic stroke. 61
23092062 2012
422
Nonarteritic anterior ischemic optic neuropathy and double thrombophilic defect: a new observation. 61
22529804 2012
423
Implantation of left ventricular assist device complicated by undiagnosed thrombophilia. 61
23109751 2012
424
Placental fetal vascular thrombosis lesions and maternal thrombophilia. 61
22173239 2012
425
New quantitative total protein S-assay system for diagnosing protein S type II deficiency: clinical application of the screening system for protein S type II deficiency. 61
22157257 2012
426
Avascular necrosis of hip following combined protein C and protein S deficiency. 61
22253170 2011
427
Internal jugular vein thrombosis associated with venous hypoplasia and protein S deficiency revealed by ultrasonography. 61
21931986 2011
428
Thrombophilia in patients with chronic venous leg ulcers-a study on patients with or without post-thrombotic syndrome. 61
21392126 2011
429
Headache and aphasia in a young woman with protein S deficiency and nephrotic syndrome. 61
22649897 2011
430
Cerebral thrombosis complicating Crohn's disease: two cases. 61
22078296 2011
431
Penile necrosis due to priapism developed after circumcision in a patient with protein S deficiency. 61
21810192 2011
432
Coagulation inhibitors and activated protein C resistance in recurrent pregnancy losses in Indian women. 61
22234103 2011
433
Protein S deficiency with a PROS1 gene mutation in a patient presenting with mesenteric venous thrombosis following total colectomy. 61
21799399 2011
434
Prothrombotic profile in children with peripheral gangrene: a single center experience. 61
20699261 2011
435
Spontaneous Carotid Cavernous Fistula in a Case with Protein S Deficiency that Newly Developed Ophthalmoplegia after Embolization. 61
22087212 2011
436
Thrombophilic factors in Stage V chronic kidney disease patients are largely corrected by renal transplantation. 61
21285127 2011
437
The vascular adverse events of protein S deficiency: a case report. 61
21746800 2011
438
Isolated distal cutaneous thrombosis: an unusual presentation and an interesting etiology. 61
21727698 2011
439
A novel integrative network approach to understand the interplay between cardiovascular disease and other complex disorders. 61
21559538 2011
440
High incidence of hepatitis B infection-associated cirrhosis and hepatocellular carcinoma in the Southeast Asian patients with portal vein thrombosis. 61
21658275 2011
441
Deep vein thrombosis associated with protein C and protein S deficiency: an unusual cause of acute abdomen. 61
21547930 2011
442
Superficial thrombophlebitis in varicose vein disease: the particular role of methylenetetrahydrofolate reductase. 61
20881312 2011
443
[Topical tacrolimus in necrobiosis lipoidica]. 61
20953573 2011
444
[Recurrent deep vein thrombosis caused by heterozygous missense mutation of the protein S gene: genetic analysis of a case]. 61
21764702 2011
445
[Unilateral adrenal ischemia during third trimester of pregnancy: about two cases]. 61
21514203 2011
446
Empiric treatment of protracted idiopathic purpura fulminans in an infant: a case report and review of the literature. 61
21605440 2011
447
Mesenteric venous thrombosis in a child with type 2 protein S deficiency. 61
21285903 2011
448
The selective estrogen receptor modulator DT56a (Femarelle) does not affect platelet reactivity in normal or thrombophilic postmenopausal women. 61
21037489 2011
449
Saddle pulmonary thromboembolism with zero Wells' score. 61
21476378 2011
450
Thrombophilic screening in young patients (< 40 years) with idiopathic ischemic stroke: a controlled study. 61
21172722 2011
451
HIV-Associated Venous Thromboembolism. 61
21869916 2011
452
Arterial thrombosis in patients with human immunodeficiency virus: two-case reports and review of the literature. 61
22937467 2011
453
Protein S deficiency in a case of superor sagital vein thrombosis. 61
23134945 2011
454
A rare splicing mutation in the PROS1 gene of a Korean patient with type I hereditary protein S deficiency. 61
22166512 2011
455
Is thrombophilia testing useful? 61
22160027 2011
456
Treatment of adverse perinatal outcome in inherited thrombophilias: a clinical study. 61
21042205 2011
457
Massive pulmonary embolism arising from a bifid ovarian vein in a patient with protein S deficiency. 61
22113762 2011
458
Acute thrombosis of the superior mesenteric artery in a 39-year-old woman with protein-S deficiency: a case report. 61
21244677 2011
459
[Severe thrombotic complications in the postoperative period in a child after removal of craneopharyngeoma]. 61
21513072 2011
460
A genome-wide association study of the Protein C anticoagulant pathway. 61
22216198 2011
461
Testing for inherited thrombophilias in arterial stroke: can it cause more harm than good? 61
20947844 2010
462
Recurrent and consecutive non-arteritic optic neuropathy in a patient with protein S deficiency. 61
21135426 2010
463
Protein C and/or protein S deficiency and occurrence of stent thrombosis: a hitherto unrecognized association. 61
20825554 2010
464
Post varicella disseminated intravascular coagulation and transient protein S deficiency in an otherwise healthy 6-year-old boy: a case report. 61
20844918 2010
465
Chickenpox is not always benign: postvaricella purpura fulminans requires prompt and aggressive treatment. 61
21131808 2010
466
Genetic predisposition of white matter infarction with protein S deficiency and R355C mutation. 61
21172841 2010
467
Protein S inherited qualitative deficiency: novel mutations and phenotypic influence. 61
20880255 2010
468
[Genetic diagnostics of pathogenic splicing abnormalities in the clinical laboratory--pitfalls and screening approaches]. 61
21348235 2010
469
Mesenteric ischemia and protein S deficiency: a rare case report. 61
18180128 2010
470
[Screening for thrombophilic abnormalities in very elderly patients]. 61
21159577 2010
471
The association of thrombophilia with fetal growth restriction. 61
21039002 2010
472
EFNS guideline on the treatment of cerebral venous and sinus thrombosis in adult patients. 61
20402748 2010
473
Postinfectious purpura fulminans secondary to varicella-induced protein S deficiency. 61
20520582 2010
474
Similar hypercoagulable state and thrombosis risk in type I and type III protein S-deficient individuals from families with mixed type I/III protein S deficiency. 61
20421270 2010
475
Novel management of post varicella purpura fulminans owing to severe acquired protein S deficiency. 61
20625278 2010
476
Thrombophilia and the risk of thromboembolic events in women on oral contraceptives and hormone replacement therapy. 61
20581664 2010
477
Postvaricella purpura fulminans with no evidence of disseminated intravascular coagulation (DIC) or protein S deficiency. 61
21404754 2010
478
Severe arterial thrombosis in a family with type III protein S deficiency caused by a frameshift mutation in the PROS1 gene. 61
20398916 2010
479
Inherited thrombophilia is associated with pregnancy losses that occur after 12th gestational week in Serbian population. 61
19520681 2010
480
A study on thrombophilic factors in Italian Behcet's patients. 61
20452800 2010
481
Risk factors and presentations of periventricular venous infarction vs arterial presumed perinatal ischemic stroke. 61
20625091 2010
482
Long-term evaluation of the risk of recurrence after cerebral sinus-venous thrombosis. 61
20547928 2010
483
Thrombophilic risk factors in the pathogenesis of non-arteritic anterior ischemic optic neuropathy patients. 61
20162297 2010
484
Altered reference ranges for protein C and protein S during early pregnancy: Implications for the diagnosis of protein C and protein S deficiency during pregnancy. 61
20174758 2010
485
Compound heterozygosity of the protein S-gene as a cause of severe cerebral sinovenous thrombosis in a 7-year-old child. 61
20514628 2010
486
Similar hypercoagulable state and thrombosis risk in type I and type III protein S-deficient individuals from mixed type I/III families. 61
20378562 2010
487
Impact of thrombophilia on risk of arterial ischemic stroke or cerebral sinovenous thrombosis in neonates and children: a systematic review and meta-analysis of observational studies. 61
20385928 2010
488
Thrombin generation-based assays to measure the activity of the TFPI-protein S pathway in plasma from normal and protein S-deficient individuals. 61
20088940 2010
489
Protein C and Protein S: causative factor for developing a hemorrhagic infarct in a HbE/Beta thalassemia child. 61
20091374 2010
490
Protein C and protein S deficiency presenting as deep venous thrombosis. 61
20228434 2010
491
Hereditary and acquired protein S deficiencies are associated with low TFPI levels in plasma. 61
20002538 2010
492
Intracerebral mass bleeding in a term neonate: manifestation of hereditary protein S deficiency with a new mutation in the PROS1 gene. 61
20484936 2010
493
Coagulation abnormalities in Legg-Calvé-Perthes disease. 61
20048104 2010
494
Esophageal varices in chronic intestinal insufficiency in absence of portal hypertension or liver cirrhosis: case report. 61
20172290 2010
495
Novel human pathological mutations. Gene symbol: PROS1. Disease: Protein S deficiency. 61
20108435 2010
496
Deep vein thrombosis in protein S deficiency. 61
21180223 2010
497
Thrombophilia investigation in Malaysian women with recurrent pregnancy loss. 61
20144172 2009
498
Anesthetic management for cesarean section in a patient with Budd-Chiari syndrome: A case report. 61
30625971 2009
499
Venous thrombembolism, thrombophilic defects, combined oral contraception and anticoagulation. 61
19242703 2009
500
Thrombosis associated with varicella zoster in an adult. 61
19398362 2009
501
Cerebral venous thrombosis in Saudi Arabia. Clinical variables, response to treatment, and outcome. 61
21048649 2009
502
[Thrombophilia, preeclampsia and other pregnancy complications]. 61
20034330 2009
503
Venous thrombosis and pulmonary embolism in a child with pneumonia due to Mycoplasma pneumoniae. 61
19806855 2009
504
Acute renal vein thrombosis, oral contraceptives, and protein S deficiency: a successful catheter-directed thrombolysis. 61
19631501 2009
505
Acute mesenteric venous thrombosis due to protein S deficiency in a pregnant woman. 61
19751348 2009
506
Regulation of TFPI function by protein S. 61
19630792 2009
507
Protein S deficiency: Recurrent ischemic stroke in young. 61
20174500 2009
508
Nonbacterial purpura fulminans and severe autoimmune acquired protein S deficiency associated with human herpesvirus-6 active replication. 61
19545295 2009
509
Acquired protein S deficiency leads to obliterative portal venopathy and to compensatory nodular regenerative hyperplasia in HIV-infected patients. 61
19512859 2009
510
Acute mesenteric venous thrombosis: improved outcome with early diagnosis and prompt anticoagulation therapy. 61
19332155 2009
511
Selective testing for thrombophilia in patients with first venous thrombosis: results from a retrospective family cohort study on absolute thrombotic risk for currently known thrombophilic defects in 2479 relatives. 61
19139080 2009
512
First case of protein S deficiency due to a translocation t(3;21)(q11.2;q22). 61
19404554 2009
513
Percutaneous device closure of patent foramen ovale in patients with presumed cryptogenic stroke or transient ischemic attack: the Mayo Clinic experience. 61
19463462 2009
514
Cyproterone acetate- and ethinyloestradiol-containing oral contraceptive as a risk factor for upper extremity deep venous thrombosis-a case report. 61
19340712 2009
515
Thrombophilia: 2009 update. 61
19289024 2009
516
Pregnancy and delivery in patients with portal vein cavernoma. 61
19672089 2009
517
Thrombophilia and its impact on pregnancy. 61
19203641 2009
518
Deep venous thrombosis related to protein S deficiency revealing celiac disease. 61
19098891 2009
519
Extrahepatic portal hypertension due to familial protein S deficiency. 61
19179724 2009
520
Acute renal cortical necrosis due to acquired antiprotein S antibodies. 61
18777044 2009
521
Recurrent priapism in sickle cell trait with protein S deficiency. 61
19157328 2008
522
[Molecular biology and haemostasis]. 61
19132159 2008
523
[Purpura fulminans: a rare complication of chickenpox]. 61
19055261 2008
524
Protein S deficiency: a clinical perspective. 61
18479427 2008
525
Maternal thrombophilias are associated with specific placental lesions. 61
18712951 2008
526
Gene symbol: PROS1. Disease: Protein S deficiency. 61
18846658 2008
527
Gene symbol: PROS1. Disease: Protein S deficiency. 61
18846666 2008
528
Regulation of coagulation by protein S. 61
18695379 2008
529
TIPS can be lifesaving in acute liver failure associated with portal vein and inferior vena cava thrombosis in a case of Budd Chiari syndrome due to protein S deficiency. 61
18046604 2008
530
Relationship between progression to AIDS and thrombophilic abnormalities in HIV infection. 61
18451311 2008
531
[Unusual venous thrombosis revealing a human immunodeficiency virus infection and a protein S deficiency. Two cases and literature review]. 61
18304701 2008
532
Simultaneous thrombosis of cerebral artery and venous sinus. 61
18686652 2008
533
[Anesthetic management of cesarean section in a patient with pulmonary embolism due to protein S deficiency diagnosed postoperatively]. 61
18546911 2008
534
[Treatment to pregnant women with deep venous thrombosis experience at Instituto Nacional de Perinatología]. 61
18798428 2008
535
Protein S deficiency. 61
18379009 2008
536
Acute thrombosis of abdominal aorta and hypercoagulable disorders. 61
18427402 2008
537
Denaturing high-performance liquid chromatography mutation analysis in patients with reduced Protein S levels. 61
18242167 2008
538
Anticoagulant therapy and pregnancy. 61
29662414 2008
539
[Portal and mesenteric thrombosis associated with protein S deficiency]. 61
18366271 2008
540
Thrombophilia in the young. 61
18278157 2008
541
High prevalence of inherited thrombophilia in 'presumed peri-neonatal' ischemic stroke. 54
18028429 2008
542
Thrombophilia and its impact on pregnancy. 61
18521490 2008
543
A case of hereditary protein S deficiency presenting with cerebral sinus venous thrombosis and deep vein thrombosis at high altitude. 61
18434709 2008
544
Multifactorial thrombophilia in a pregnancy: a case report. 61
17895510 2008
545
Initial and mid-term outcomes of pulse infusion thrombolysis using a unique pump system and stent placement for deep vein thrombosis. 61
18827413 2008
546
Warfarin-induced skin necrosis and leukocytoclastic vasculitis in a patient with acquired protein C and protein S deficiency. 61
17982324 2007
547
Haemoperitoneum from corpus luteal rupture in a patient with protein S deficiency receiving anticoagulant therapy. 61
17713778 2007
548
Heparin-induced skin necrosis associated with thrombocytopenia and acquired protein C and protein S deficiency. 61
17722075 2007
549
Risk factors of venous thromboembolism in thai patients. 61
18192106 2007
550
Protein S deficiency and retinal arteriolar occlusion in pregnancy. 61
18050134 2007
551
Treatment of massive cardiac thrombi in a patient with protein C and protein S deficiency. 61
17890961 2007
552
Unbalanced protein S deficiency due to warfarin treatment as a possible cause for thrombosis. 61
17897308 2007
553
Molecular basis of protein S deficiency. 61
17849042 2007
554
Protein S deficiency with homozygous factor V Leiden mutation in central retinal vein occlusion. 61
17641719 2007
555
High risk of pregnancy-related venous thromboembolism in women with multiple thrombophilic defects. 54
17555454 2007
556
[A case of portal vein thrombosis associated with congenital protein S deficiency]. 61
17548950 2007
557
[Celiac artery thrombosis and splenic infarction in a patient with protein s deficiency]. 61
17641558 2007
558
Use of a functional assay to diagnose protein S deficiency; inappropriate testing yields equivocal results. 61
17535386 2007
559
Mesenteric venous thrombosis. Associated systemic disorders and hypercoagulability status of 21 surgical patients. 61
17629043 2007
560
The etiologic distribution of thrombophilic factors in chronic portal vein thrombosis. 61
17450038 2007
561
Protein S deficiency manifesting simultaneously as central retinal artery occlusion, oculomotor nerve palsy, and systemic arterial occlusive diseases. 61
17259919 2007
562
Protein Z/Z-dependent protease inhibitor (PZ/ZPI) anticoagulant system and thrombosis. 61
17391489 2007
563
Protein S deficiency and lower-extremity arterial thrombosis: complicating a common presentation. 61
17369323 2007
564
Catheter-directed thrombolysis of acute deep vein thrombosis in the lower extremity of a child with interrupted inferior vena cava. 61
16967222 2007
565
Some recent insights into the prothrombogenic mechanisms of antiphospholipid antibodies. 61
17346165 2007
566
Association of protein S p.Pro667Pro dimorphism with plasma protein S levels in normal individuals and patients with inherited protein S deficiency. 61
17157360 2007
567
The diagnostic dilemma: dual presentations of clinical mucosal bleeding and venous thrombosis associated with the presence of thrombophilia markers and mild reduction in von Willebrand factor. 61
18192144 2007
568
Central retinal vein occlusion secondary to protein S deficiency. 61
18025659 2007
569
Pulmonary and deep vein thrombosis in a young patient with protein S deficiency: report of a case. 61
17643209 2007
570
Thrombophilia in cardiac surgery--patients with protein S deficiency. 61
17126133 2006
571
Cavernous transformation of the portal vein: etiology determines the outcome. 61
17153448 2006
572
Fondaparinux is a safe alternative in case of heparin intolerance during pregnancy. 61
16645165 2006
573
In vitro characterization of missense mutations associated with quantitative protein S deficiency. 61
16961607 2006
574
Intracardiac thrombus and pulmonary embolism with cavitation and pneumomediastinum in a patient with protein S deficiency. 61
16915068 2006
575
Atypical warfarin-induced skin necrosis. 61
16863494 2006
576
Recurrent strokes in a young patient with papillary fibroelastoma: a case report and literature review. 61
16911335 2006
577
Testicular infarction secondary to protein S deficiency: a case report. 61
16827935 2006
578
Identification of patients at low risk for recurrent venous thromboembolism by measuring thrombin generation. 54
16868297 2006
579
The prevalence of thrombophilia in patients with symptomatic peripheral vascular disease. 61
16607693 2006
580
Moyamoya syndrome as a risk factor for stroke in Saudi children. Novel and usual associations. 61
16532134 2006
581
[Successful delivery following subcutaneous heparin administration in a 7-weeks pregnant patient suffering from cerebral venous thrombosis due to secondary protein S deficiency]. 61
16642938 2006
582
Cardiopulmonary bypass for a coronary artery bypass graft patient with heterozygous protein C deficiency and protein S deficiency. 61
16615690 2006
583
Hemiconvulsion, hemiplegia, epilepsy syndrome and inherited protein S deficiency. 61
16514228 2006
584
[Inferior vena cava malformations and deep venous thrombosis]. 61
16540040 2006
585
Protein S stimulates inhibition of the tissue factor pathway by tissue factor pathway inhibitor. 61
16488980 2006
586
Severe thrombophilic diathesis starting with hepatic vein thrombosis (BUDD-CHIARI syndrome) in a family with a new Protein S gene mutation. 61
16673558 2006
587
Diagnostic approach to hypercoagulable states. 54
17125064 2006
588
Portal vein thrombosis in a patient with HIV treated with a protease inhibitor-containing regimen. 61
16673613 2006
589
Thrombophilia and pregnancy complications. 61
16444325 2006
590
Molecular bases of type II protein S deficiency: the I203-D204 deletion in the EGF4 domain alters GLA domain function. 61
16409468 2006
591
Characterization of endoplasmic reticulum-associated degradation of a protein S mutant identified in a family of quantitative protein S deficiency. 61
15893367 2006
592
[Spontaneous skin necrosis from acquired protein S deficiency in a renal transplant recipient]. 61
16374391 2005
593
Alexia without agraphia following cerebral venous thrombosis associated with protein C and protein S deficiency. 61
16311147 2005
594
Prevalence of inherited prothrombotic abnormalities and central venous catheter-related thrombosis in haematopoietic stem cell transplants recipients. 61
16151418 2005
595
Hematologic complications of HIV infection. 61
16425959 2005
596
HIV infection and stroke: if not protein S deficiency then what explains the relationship? 61
16170070 2005
597
Protein S deficiency in HIV associated ischaemic stroke: an epiphenomenon of HIV infection. 61
16170096 2005
598
Hepatocavopathy and isolated splenic vein thrombosis due to hypercoagulability state. 61
16245227 2005
599
Protein S deficiency is common in a healthy Thai population. 61
16623037 2005
600
[Celiac disease, cerebral venous thrombosis and protein S deficiency, a fortuitous association?]. 61
16292200 2005
601
Deep venous thrombosis, protein S deficiency and homozygous Factor XII 46T mutation. 61
15912386 2005
602
Unusual thromboses associated with protein S deficiency in patients with acquired immunodeficiency syndrome: case reports and review of the literature. 61
16218798 2005
603
Degos disease associated with protein S deficiency. 61
16120164 2005
604
Prevalence of prothrombotic abnormalities in patients with acute mesenteric ischemia. 54
16086214 2005
605
Thrombophilia and pregnancy outcomes. 61
16102025 2005
606
[Atypical venous thrombosis and protein S deficiency: report of a case]. 61
16104624 2005
607
Bilateral internal jugular vein thrombosis in a child with protein S deficiency. 61
16102229 2005
608
[Klinefelter's syndrome associated with mixed connective tissue disease (Sharp's syndrome) and thrombophilia with postthrombotic syndrome]. 61
16033481 2005
609
Protein S and congenital protein S deficiency: the most frequent congenital thrombophilia in Japanese. 61
16026279 2005
610
Calciphylaxis: a rare association with alcoholic cirrhosis. Are deficiencies in protein C and S the cause? 61
16108246 2005
611
Hemobilia in a patient with protein S deficiency after laparoscopic cholecystectomy that caused acute pancreatitis: successful endoscopic management. 61
15990843 2005
612
[Prevalence of thrombophilia in patients with severe ovarian hyperstimulation syndrome]. 54
16128122 2005
613
Anti-protein S antibodies following a varicella infection: detection, characterization and influence on thrombin generation. 61
15946215 2005
614
Protein S assays: an analysis of North American Specialized Coagulation Laboratory Association proficiency testing. 61
15981819 2005
615
Retinal vein thrombosis associated with a herbal phytoestrogen preparation in a susceptible patient. 61
15811894 2005
616
Thrombophilia and first arterial ischaemic stroke: a systematic review. 61
15781933 2005
617
Cardiopulmonary bypass in patients with pre-existing coagulopathy. 61
15804152 2005
618
[Retinal vein branch occlusion and palsy of the N. abducens in protein S deficiency]. 61
15138794 2005
619
Protein S type III deficiency is no risk factor for venous and arterial thromboembolism in 168 thrombophilic families: a retrospective study. 61
15741801 2005
620
Hemorrhagic stroke in a child with protein S and factor VII deficiencies. 61
15730905 2005
621
Molecular diversity and thrombotic risk in protein S deficiency: the PROSIT study. 61
15712227 2005
622
Difference in absolute risk of venous and arterial thrombosis between familial protein S deficiency type I and type III. Results from a family cohort study to assess the clinical impact of a laboratory test-based classification. 61
15725093 2005
623
[Inherited thrombophilia]. 54
15844771 2005
624
Prevalence of thrombophilia and catheter-related thrombosis in cystic fibrosis. 61
15633202 2005
625
Spontaneous Achilles tendon rupture in a patient with systemic lupus erythematosus due to ischemic necrosis after methyl prednisolone pulse therapy. 61
15864919 2005
626
Inherited thrombophilia: an update. 54
16122145 2005
627
Thrombophilic abnormalities and recurrence of venous thromboembolism in patients treated with standardized anticoagulant treatment. 54
16038714 2005
628
Impending paradoxical embolism across a patent foramen ovale: case report. 61
15769715 2005
629
Effects of anticoagulation protein defect in maternal plasma on spontaneous abortion. 61
15669191 2004
630
[Cerebral infarction of arterial origin and haematological causation: the Lausanne experience and a review of the literature]. 61
15602345 2004
631
Protein S deficiency associated with progressive loss of vision and intracranial venous sinus thrombosis. 61
15648287 2004
632
Postmenopausal HRT is not independent risk factor for dural sinus thrombosis. 61
15272905 2004
633
Frequency of hereditary thrombophilia: an AKUH experience. 61
15461212 2004
634
[Portal vein thrombosis in a patient with lowered protein S level]. 61
15314742 2004
635
Primary upper-extremity deep vein thrombosis: high prevalence of thrombophilic defects. 61
15282664 2004
636
Coumarin necrosis induced by renal insufficiency. 61
15327563 2004
637
Identification of protein Salpha gene mutations including four novel mutations in eight unrelated patients with protein S deficiency. 61
15238143 2004
638
Association between the acquired free protein S deficiency in HIV-infected patients with the lipid profile levels. 61
15219212 2004
639
A life-threatening second trimester disseminated intravascular coagulopathy with protein s deficiency. 61
15247990 2004
640
N-Terminal domain linkage modulates the folding properties of protein S epidermal growth factor-like modules. 61
15260478 2004
641
The prevalence of, and molecular defects underlying, inherited protein S deficiency in the general population. 61
15147381 2004
642
Prevalence of protein S deficiency in the Japanese general population: the Suita Study. 61
15140145 2004
643
Stroke and seizure following a recent laparoscopic Roux-en-Y gastric bypass. 61
15318995 2004
644
Inherited prothrombotic defects in Budd-Chiari syndrome and portal vein thrombosis: a study from North India. 61
15198356 2004
645
Central retinal vein prethrombosis as an initial manifestation of protein S deficiency. 61
15448814 2004
646
Deep vein thrombosis associated with distension of the urinary bladder due to benign prostatic hypertrophy--a case report. 61
15255085 2004
647
Prevalence of thrombophilia in women with severe ovarian hyperstimulation syndrome and cost-effectiveness of screening. 54
15066453 2004
648
[Spontaneous pneumothorax secondary to lung infarct in patient with protein S deficiency]. 61
15025989 2004
649
Protein S deficiency in the presence of weak lupus anticoagulant resulting in right ventricular thrombosis. 61
16166949 2004
650
A case of warfarin skin necrosis despite enoxaparin anticoagulation in a patient with protein S deficiency. 61
15253263 2004
651
Central retinal vein occlusion in sickle cell disease. 61
14982276 2004
652
Acute myocardial infarction caused by embolism of thrombus in the right coronary sinus of Valsalva: a case report and review of the literature. 61
14752493 2004
653
Successful treatment of massive pulmonary embolism in the 38th week of pregnancy. 61
14759462 2004
654
Venous thrombosis among patients with AIDS. 61
14979401 2004
655
[Non-Hodgkin's lymphoma with protein S deficiency]. 61
14700757 2004
656
Bilateral pulmonary artery aneurysms with protein C and protein S deficiency in a patient with Behçet's disease. 61
15124944 2004
657
Portal and mesenteric vein thrombosis after portal vein embolization in a patient with protein S deficiency. 61
15549434 2004
658
Purpura fulminans in a child as a complication of chickenpox infection. 61
15118384 2004
659
[Unilateral decompressive craniectomy in left transverse and sigmoid sinus thrombosis]. 61
15306978 2004
660
The ability of three global plasma assays to recognize thrombophilia. 61
15226097 2004
661
Anaesthetic management of the parturient with protein S deficiency and lumboperitoneal shunt. 61
14601283 2003
662
Acquired protein C and protein S deficiency in HIV-infected patients. 61
14653442 2003
663
Venous thrombosis: prevalence of prothrombotic defects in north Indian population. 61
15025358 2003
664
Surgical treatment of Budd-Chiari syndrome. 61
12942449 2003
665
Protein S deficiency presenting as deep vein thrombosis--a case report. 61
14565637 2003
666
[Evaluation of a functional test in the screening of protein S deficiency]. 61
14671760 2003
667
Acquired protein S deficiency in thrombotic thrombocytopenic purpura patients receiving solvent/detergent plasma exchange. 61
12877681 2003
668
Oral anticoagulant therapy in venous thromboembolism. 61
15199464 2003
669
Recurrent thrombosis despite anticoagulation in a man with monocytosis. Case 8. 61
12923583 2003
670
Normal functional protein S activity does not exclude protein S deficiency. 61
15583450 2003
671
Risk of venous thromboembolism in relatives of symptomatic probands with thrombophilia: a systematic review. 61
12876621 2003
672
[Portal vein thrombosis associated with factor V Leiden mutation in a woman who underwent exchange transfusion at birth]. 61
12910230 2003
673
Primary thrombophilia in Saudi Arabia. 61
12847589 2003
674
[Obstetric aspects of hereditary thrombophilias: epidemiology, complications and prophylaxis]. 61
12931469 2003
675
Sensitivity of functional protein S assays to protein S deficiency: a comparative study of three commercial kits. 61
12871384 2003
676
Subchorionic hematoma associated with thrombophilia: report of three cases. 61
12658542 2003
677
Inherited protein S deficiency: from genotype to phenotype. 61
12681962 2003
678
A novel G-to-A mutation in the intron-N of the protein S gene leading to abnormal RNA splicing in a patient with protein S deficiency. 61
12681974 2003
679
Epidemiological characteristics of acute pulmonary thromboembolism in Japan. 61
12771856 2003
680
[Cerebral sinus thrombosis and ulcerative colitis: two cases]. 61
12712883 2003
681
Combined protein C and protein S deficiency in a family with repetitive thromboembolism and segregated gene mutations. 61
12705793 2003
682
Thrombophilic disorders and fetal loss: a meta-analysis. 61
12648968 2003
683
Hereditary protein s deficiency with a history of recurrent myocardial infarction. 61
12548002 2003
684
Diagnosing protein S deficiency: analytical considerations. 61
12705691 2003
685
Protein S deficiency in repetitive superficial thrombophlebitis. 61
12643325 2003
686
Different circumstances of the first venous thromboembolism among younger or older heterozygous carriers of the G20210A polymorphism in the prothrombin gene. 54
12551828 2003
687
Pseudo-protein S deficiency due to activated protein C resistance. 61
15041281 2003
688
Outcome of kidney transplantation in patients with inherited thrombophilia: data of a prospective study. 54
12506156 2003
689
Stroke in black South African HIV-positive patients: a prospective analysis. 61
12511743 2003
690
Multicentre evaluation of IL Test Free PS: a fully automated assay to quantify free protein S. 61
12529748 2002
691
Overall haemostasis potential assays performed in thrombophilic plasma: the effect of preactivating protein C and antithrombin. 61
12676193 2002
692
Necrosis of the toe resulting from protein-s deficiency. 61
12409796 2002
693
Prevalence of factor V G1691A (Leiden), prothrombin G20210A, and methylene tetrahydrofolate reductase C677T thrombophilic mutations in children with inflammatory bowel disease. 61
12454577 2002
694
Acute digital gangrene in a long-term dialysis patient -- a diagnostic challenge. 61
12444385 2002
695
A review of the technical, diagnostic, and epidemiologic considerations for protein S assays. 61
12421142 2002
696
Serendipitous diagnosis of protein S deficiency. 61
12416779 2002
697
Protein S Gla-domain mutations causing impaired Ca(2+)-induced phospholipid binding and severe functional protein S deficiency. 61
12351389 2002
698
Pathogenesis of venous thromboembolism. 54
12172436 2002
699
Protein S deficiency. Description of a case associated with chronic inflammatory bowel disease. 61
12207201 2002
700
Inferior vena caval thrombosis with sickle cell disease and heterozygous protein s deficiency. 61
12218606 2002
701
Dural arteriovenous fistula after craniotomy for pilocytic astrocytoma in a patient with protein S deficiency. 61
12361657 2002
702
Effects of hereditary and acquired risk factors of venous thrombosis on a thrombin generation-based APC resistance test. 61
12152677 2002
703
[Genetic risk factors of thrombosis]. 54
12471642 2002
704
Hypercoagulability test strategies in the protein C and protein S pathway. 61
12134467 2002
705
Postvaricella purpura fulminans caused by acquired protein s deficiency resulting from antiprotein s antibodies: search for the epitopes. 61
12142795 2002
706
The association of Mondor's disease with protein S deficiency: case report and review of literature. 61
12355037 2002
707
Calciphylaxis: emerging concepts in prevention, diagnosis, and treatment. 61
12100455 2002
708
Inherited thrombophilia and first venous thromboembolism during pregnancy and puerperium. 61
12038778 2002
709
Protein S gene mutation in a young woman with type III protein S deficiency and venous thrombosis during pregnancy. 61
12101385 2002
710
The prevalence of thrombophilia in patients with chronic venous leg ulceration. 54
11932669 2002
711
Thromboplastin-thrombomodulin-mediated time: a new global test sensitive to protein S deficiency and increased levels of factors II, V, VII and X. 61
11940486 2002
712
Cerebral venous thrombosis due to protein S deficiency in pregnancy. 61
11897316 2002
713
[Four years followup of complicated Cockett syndrome treated by iliac vein endoprosthesis]. 61
11998330 2002
714
Genetic and phenotypic variability between families with hereditary protein S deficiency. 61
11858485 2002
715
Four missense mutations identified in the protein S gene of thrombosis patients with protein S deficiency: effects on secretion and anticoagulant activity of protein S. 61
11927129 2002
716
[Idiopathic intracranial hypertension associated with inferior vena cava thrombosis and protein S deficiency]. 61
12022062 2002
717
Calciphylaxis in a patient with rheumatoid arthritis without renal failure and hyperparathyroidism: the possible role of long-term steroid use and protein S deficiency. 61
11954890 2002
718
Hereditary thrombophilia in elite athletes. 61
11828228 2002
719
Protein S deficiency manifesting as spontaneous aortic thrombosis in a neonate. 61
12793929 2002
720
Protected iliofemoral venous thrombectomy in a pregnant woman with pulmonary embolism and ischemic venous thrombosis. 61
12075871 2002
721
Deep venous thrombosis associated with pulmonary tuberculosis and transient protein S deficiency. 61
12069029 2002
722
Thrombophilic markers in patients with congenital bleeding disorders. 61
12803120 2002
723
Hereditary deficiencies of antithrombin III, protein S, and the protein C pathway in Jordanian thrombosis patients. 61
12776777 2002
724
Recurrent pulmonary embolism in a 13-year-old male homozygous for the prothrombin G20210A mutation combined with protein S deficiency and increased lipoprotein (a). 61
11864707 2002
725
Hereditary protein S deficiency associated with rheumatoid arthritis: a case report of pulmonary embolism after total hip arthroplasty. 61