MCID: PRT014
MIFTS: 46

Protein S Deficiency

Categories: Blood diseases, Rare diseases

Aliases & Classifications for Protein S Deficiency

MalaCards integrated aliases for Protein S Deficiency:

Name: Protein S Deficiency 12 77 54 26 30 56 6 45 15 41 74
Hereditary Thrombophilia Due to Protein S Deficiency 26
Protein S Deficiency Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2451
MeSH 45 D018455
NCIt 51 C99026
SNOMED-CT 69 1563006
ICD10 34 D68.59
UMLS 74 C0242666

Summaries for Protein S Deficiency

NIH Rare Diseases : 54 Protein S deficiency is a disorder that causes abnormal blood clotting. When someone bleeds, the blood begins a complicated series of rapid chemical reactions involving proteins called blood coagulation factors to stop the bleeding.  Other proteins in the blood, such as protein S, usually regulate these chemical reactions to prevent excessive clotting. When protein S is missing (deficient), clotting may not be regulated normally and affected individuals have an increased risk of forming a blood clot called a thrombosis.  People at risk to have protein S deficiency are those with an individual or family history of multiple blood clots in the veins.  Treatment may include taking medication known as blood thinners to decrease the chance of developing a blood clot.

MalaCards based summary : Protein S Deficiency, also known as hereditary thrombophilia due to protein s deficiency, is related to purpura fulminans and coronary thrombosis. An important gene associated with Protein S Deficiency is PROS1 (Protein S), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Enoxaparin and Thrombin have been mentioned in the context of this disorder. Affiliated tissues include skin, heart and testes, and related phenotypes are homeostasis/metabolism and embryo

Genetics Home Reference : 26 Protein S deficiency is a disorder of blood clotting. People with this condition have an increased risk of developing abnormal blood clots.

Wikipedia : 77 Protein S deficiency is a disorder associated with increased risk of venous thrombosis.Protein S, a... more...

Related Diseases for Protein S Deficiency

Diseases related to Protein S Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 234, show less)
# Related Disease Score Top Affiliating Genes
1 purpura fulminans 30.1 F2 F3 PROS1 SERPINC1
2 coronary thrombosis 29.9 F3 SERPINC1
3 sticky platelet syndrome 29.8 F5 SERPINC1
4 anterior spinal artery syndrome 29.8 F2 SERPINC1
5 heparin-induced thrombocytopenia 29.8 F3 SERPINC1
6 sagittal sinus thrombosis 29.8 F2 F3 F5 SERPINC1
7 osteonecrosis 29.7 F2 MTHFR SERPINC1
8 acute liver failure 29.6 F2 F5
9 disseminated intravascular coagulation 29.6 F2 F3 F5 SERPINC1
10 endocarditis 29.5 APOH F2 SERPINC1
11 protein c deficiency 29.5 F2 F5 MTHFR SERPINC1
12 homocysteinemia 29.5 F2 F5 MTHFR SERPINC1
13 purpura 29.4 APOH F2 F3 PROS1 SERPINC1
14 afibrinogenemia 29.4 F2 F3 F5
15 thrombosis 29.3 APOH F2 F3 F5 MTHFR PROS1
16 infective endocarditis 29.3 APOH F2
17 sneddon syndrome 29.2 APOH F2 SERPINC1
18 thrombophilia due to thrombin defect 29.2 APOH F2 F3 F5 MTHFR SERPINC1
19 severe pre-eclampsia 29.2 APOH F5 SERPINC1
20 myocardial infarction 29.2 F2 F3 F5 MTHFR SERPINC1
21 behcet syndrome 29.1 APOH F5 SERPINC1
22 thrombotic thrombocytopenic purpura 29.1 APOH F3
23 sickle cell anemia 29.1 F2 MTHFR
24 portal vein thrombosis 29.0 APOH F2 F5 MTHFR SERPINC1
25 heart disease 29.0 F2 F3 MTHFR SERPINC1
26 central retinal vein occlusion 28.9 APOH F2 F5 MTHFR SERPINC1
27 retinal vein occlusion 28.9 APOH F2 F5 MTHFR SERPINC1
28 pulmonary embolism 28.8 APOH F2 F3 F5 MTHFR SERPINC1
29 livedoid vasculitis 28.8 APOH F2 MTHFR SERPINC1
30 retinal artery occlusion 28.8 APOH F2 F5 MTHFR SERPINC1
31 branch retinal artery occlusion 28.7 APOH F2 F3 MTHFR SERPINC1
32 intracranial thrombosis 28.7 APOH F3 F5 MTHFR SERPINC1
33 catastrophic antiphospholipid syndrome 28.6 APOH F3 F5 MTHFR
34 thrombophilia due to activated protein c resistance 28.6 APOH F2 F3 F5 MTHFR SERPINC1
35 antiphospholipid syndrome 28.5 APOH F2 F3 F5 MTHFR SERPINC1
36 thrombophlebitis 28.4 APOH F2 F5 MTHFR SERPINC1
37 antithrombin iii deficiency 28.4 APOH F2 F5 MTHFR SERPINC1
38 thrombophilia 28.3 APOH F2 F3 F5 MTHFR PROS1
39 budd-chiari syndrome 28.3 APOH F2 F3 F5 MTHFR SERPINC1
40 stroke, ischemic 28.2 APOH F2 F3 F5 MTHFR SERPINC1
41 thrombophilia due to protein s deficiency, autosomal recessive 12.8
42 thrombophilia due to protein s deficiency, autosomal dominant 12.7
43 severe hereditary thrombophilia due to congenital protein s deficiency 12.4
44 alpha-2-plasmin inhibitor deficiency 10.2 F2 SERPINC1
45 intracranial embolism 10.2 F2 SERPINC1
46 subendocardial myocardial infarction 10.2 F2 SERPINC1
47 paracetamol poisoning 10.2 F2 F5
48 prothrombin deficiency 10.2 F2 F3
49 esophageal varix 10.2 F2 SERPINC1
50 hemoglobin e disease 10.2 F2 F5
51 hemophilia 10.2 F2 F3
52 hypersplenism 10.2 F2 SERPINC1
53 meningococcemia 10.2 F5 SERPINC1
54 cerebral falx meningioma 10.2 F2 F3
55 factor viii deficiency 10.2 F2 F5
56 mesenteric vascular occlusion 10.2 F2 MTHFR
57 qualitative platelet defect 10.2 F2 F3
58 ischemic neuropathy 10.2 F2 MTHFR
59 femoral neuropathy 10.2 F2 F3
60 inferior vena cava interruption 10.2 F5 MTHFR
61 systemic lupus erythematosus 10.2
62 lupus erythematosus 10.2
63 alcohol-related birth defect 10.2 F2 F3
64 amaurosis fugax 10.2 F5 MTHFR
65 acquired hemophilia 10.1 F3 F5
66 acquired hemophilia a 10.1 F3 F5
67 hantavirus pulmonary syndrome 10.1 F2 F3
68 hemophilia a 10.1 F3 F5
69 von willebrand disease, type 1 10.1 F2 F3
70 anterior cranial fossa meningioma 10.1 F2 F3
71 vascular hemostatic disease 10.1 F2 F3
72 splenic disease 10.1 F2 F3
73 intermediate coronary syndrome 10.1 F3 SERPINC1
74 chickenpox 10.1
75 pulmonary immaturity 10.1 F3 SERPINC1
76 endocardium disease 10.1 F2 F3
77 factor xiii deficiency 10.1 F3 F5
78 gastroschisis 10.1 F5 MTHFR
79 analbuminemia 10.1 F2 F3
80 nephrotic syndrome 10.1
81 hepatic veno-occlusive disease 10.1 F3 SERPINC1
82 squamous cell papilloma 10.1 F2 F3
83 lemierre's syndrome 10.0 F3 MTHFR
84 grange syndrome 10.0 F3 MTHFR
85 calciphylaxis 10.0
86 vasculitis 10.0
87 post-thrombotic syndrome 10.0 F2 F5 SERPINC1
88 dysfibrinogenemia 10.0 F2 F5 SERPINC1
89 factor vii deficiency 10.0 F2 F3
90 eclampsia 10.0 F2 MTHFR SERPINC1
91 leech infestation 10.0 F2 F3 SERPINC1
92 intestinal impaction 10.0 F2 F3 SERPINC1
93 fournier gangrene 10.0 F2 F3 SERPINC1
94 giant hemangioma 10.0 F2 F3 SERPINC1
95 blue toe syndrome 10.0 F2 F3 SERPINC1
96 may-thurner syndrome 10.0 APOH F5
97 korean hemorrhagic fever 10.0 F2 F3 SERPINC1
98 inherited blood coagulation disease 10.0 F2 F3 SERPINC1
99 factor xi deficiency 10.0 F2 F3 SERPINC1
100 hemophilia b 10.0 F2 F3 SERPINC1
101 acanthamoeba keratitis 10.0 APOH F5
102 papilledema 10.0 APOH F2
103 afibrinogenemia, congenital 10.0 F2 F3 SERPINC1
104 ischemia 10.0
105 human immunodeficiency virus infectious disease 10.0
106 thrombocytosis 10.0 F2 F3 SERPINC1
107 schizencephaly 10.0 F5 MTHFR
108 blood platelet disease 10.0 F2 F3 SERPINC1
109 peripheral vascular disease 10.0 F2 F3 SERPINC1
110 pregnancy loss, recurrent 1 10.0 APOH F5
111 placental insufficiency 10.0 F2 F3
112 arteritic anterior ischemic optic neuropathy 9.9 F2 F5 MTHFR
113 cryptogenic cirrhosis 9.9 F2 F5 MTHFR
114 homocystinuria 9.9 F5 MTHFR SERPINC1
115 porencephaly 9.9 F2 F5 MTHFR
116 factor v deficiency 9.9 F2 F3 F5
117 von willebrand's disease 9.9 F2 F3 F5
118 liver cirrhosis 9.9 F2 F3 SERPINC1
119 cerebral palsy 9.9 F2 F5 MTHFR
120 carotid artery occlusion 9.9 APOH F5
121 dengue hemorrhagic fever 9.9 F2 F3
122 rheumatoid arthritis 9.9
123 arthritis 9.9
124 inflammatory bowel disease 9.9
125 headache 9.9
126 cerebrovascular disease 9.9 F2 F5 MTHFR
127 glanzmann thrombasthenia 9.9 F2 F3
128 myeloma, multiple 9.8
129 arteriovenous fistula 9.8
130 thrombocytopenia 9.8
131 ulcerative colitis 9.8
132 colitis 9.8
133 central retinal artery occlusion 9.8
134 priapism 9.8
135 intermittent claudication 9.8 APOH F2 SERPINC1
136 legg-calve-perthes disease 9.8 APOH F5 SERPINC1
137 factor x deficiency 9.7 F2 F3 F5 SERPINC1
138 nonarteritic anterior ischemic optic neuropathy 9.7 F2 F5 MTHFR SERPINC1
139 varicose veins 9.7 F2 F5 MTHFR SERPINC1
140 hemorrhagic disease 9.7 F2 F3 F5 SERPINC1
141 buerger disease 9.7 APOH F2 MTHFR
142 marantic endocarditis 9.7 F2 F3 MTHFR SERPINC1
143 hepatic vascular disease 9.7 F2 F3 MTHFR SERPINC1
144 leukemia, chronic lymphocytic 2 9.7
145 exudative vitreoretinopathy 1 9.7
146 leukemia, chronic lymphocytic 9.7
147 myelopathy, htlv-1-associated 9.7
148 celiac disease 1 9.7
149 moyamoya disease 1 9.7
150 malignant atrophic papulosis 9.7
151 orthostatic intolerance 9.7
152 human immunodeficiency virus type 1 9.7
153 diabetes mellitus, ketosis-prone 9.7
154 infantile liver failure syndrome 1 9.7
155 pulmonary hypertension 9.7
156 acute myocardial infarction 9.7
157 congestive heart failure 9.7
158 crohn's disease 9.7
159 end stage renal failure 9.7
160 ischemic heart disease 9.7
161 leukemia 9.7
162 aphasia 9.7
163 lymphoma 9.7
164 cutaneous t cell lymphoma 9.7
165 agraphia 9.7
166 metal allergy 9.7
167 lymphocytic leukemia 9.7
168 protein-losing enteropathy 9.7
169 interstitial nephritis 9.7
170 portal hypertension 9.7
171 hemiplegia 9.7
172 henoch-schoenlein purpura 9.7
173 retinal vasculitis 9.7
174 graves' disease 9.7
175 telangiectasis 9.7
176 hereditary spherocytosis 9.7
177 carotid stenosis 9.7
178 alexia 9.7
179 hyperparathyroidism 9.7
180 epilepsy 9.7
181 optic nerve disease 9.7
182 dermatitis 9.7
183 acute pancreatitis 9.7
184 pulmonary tuberculosis 9.7
185 astrocytoma 9.7
186 tropical spastic paraparesis 9.7
187 cellulitis 9.7
188 mixed connective tissue disease 9.7
189 lateral sinus thrombosis 9.7
190 dysgraphia 9.7
191 pancreatitis 9.7
192 central nervous system vasculitis 9.7
193 pneumonia 9.7
194 acquired immunodeficiency syndrome 9.7
195 connective tissue disease 9.7
196 compartment syndrome 9.7
197 peritonitis 9.7
198 neuropathy 9.7
199 toxoplasmosis 9.7
200 rere-related disorders 9.7
201 sickle cell disease 9.7
202 anca-associated vasculitis 9.7
203 bowenoid papulosis 9.7
204 granulocytopenia 9.7
205 hereditary antithrombin deficiency 9.7
206 leukemia, b-cell, chronic 9.7
207 nodular regenerative hyperplasia 9.7
208 pilocytic astrocytoma 9.7
209 spastic paraparesis 9.7
210 cytomegalovirus infection 9.7
211 hepatoportal sclerosis 9.7
212 idiopathic hemiconvulsion-hemiplegia syndrome 9.7
213 thrombasthenia 9.6 F2 F3 F5 MTHFR
214 prothrombin deficiency, congenital 9.6 APOH F2 F5 SERPINC1
215 ischemic colitis 9.6 APOH F2 F5 SERPINC1
216 factor xii deficiency 9.5 APOH F3 F5 SERPINC1
217 sudden sensorineural hearing loss 9.5 APOH F2 F5 MTHFR
218 pulmonary artery disease 9.4 F2 F3 F5 MTHFR SERPINC1
219 blood coagulation disease 9.4 F2 F3 F5 MTHFR SERPINC1
220 cerebral sinovenous thrombosis 9.3 APOH F2 F3 F5 PROS1
221 spinal cord infarction 9.3 APOH F2 F5 MTHFR SERPINC1
222 retinal vascular occlusion 9.3 APOH F2 F5 MTHFR SERPINC1
223 peripheral vertigo 9.3 APOH F2 F3 F5 SERPINC1
224 placental abruption 9.3 APOH F2 F5 MTHFR SERPINC1
225 ischemic optic neuropathy 9.3 APOH F2 F5 MTHFR SERPINC1
226 patent foramen ovale 9.3 APOH F2 F5 MTHFR SERPINC1
227 blood protein disease 9.3 F2 F3 F5 MTHFR PROS1 SERPINC1
228 vein disease 9.2 F2 F3 F5 MTHFR PROS1 SERPINC1
229 hepatic infarction 9.2 APOH F2 F3 MTHFR SERPINC1
230 placenta disease 9.2 APOH F3 F5 MTHFR SERPINC1
231 intracranial hypertension 9.0 APOH F2 F3 F5 MTHFR SERPINC1
232 hellp syndrome 9.0 APOH F2 F3 F5 MTHFR SERPINC1
233 pre-eclampsia 9.0 APOH F2 F3 F5 MTHFR SERPINC1
234 vascular disease 9.0 APOH F2 F3 F5 MTHFR SERPINC1

Graphical network of the top 20 diseases related to Protein S Deficiency:



Diseases related to Protein S Deficiency

Symptoms & Phenotypes for Protein S Deficiency

MGI Mouse Phenotypes related to Protein S Deficiency:

47 (showing 5, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.8 APOH F2 F3 F5 MTHFR PROS1
2 embryo MP:0005380 9.72 F2 F3 F5 PROS1 SERPINC1
3 integument MP:0010771 9.55 F2 F3 F5 MTHFR PROS1
4 mortality/aging MP:0010768 9.5 APOH F2 F3 F5 MTHFR PROS1
5 nervous system MP:0003631 9.1 F2 F3 F5 MTHFR PROS1 SERPINC1

Drugs & Therapeutics for Protein S Deficiency

Drugs for Protein S Deficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 7, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Enoxaparin Approved Phase 3 9005-49-6 772
2
Thrombin Approved, Investigational
3 Hemostatics
4 Thromboplastin
5 protein S
6 Coagulants
7 Lipoprotein-associated coagulation inhibitor

Interventional clinical trials:

(showing 2, show less)
# Name Status NCT ID Phase Drugs
1 Prevention of Unexplained Recurrent Abortion by Enoxaparine Terminated NCT00740545 Phase 3 enoxaparine 40 mg daily;placebo
2 Study of Thrombin Generation During the 3 First Cycles of Chemotherapy in Patients With Newly Diagnosed Multiple Myeloma Completed NCT01508416

Search NIH Clinical Center for Protein S Deficiency

Cochrane evidence based reviews: protein s deficiency

Genetic Tests for Protein S Deficiency

Genetic tests related to Protein S Deficiency:

# Genetic test Affiliating Genes
1 Protein S Deficiency 30 PROS1

Anatomical Context for Protein S Deficiency

MalaCards organs/tissues related to Protein S Deficiency:

42
Skin, Heart, Testes, Brain, Bone, T Cells, Small Intestine

Publications for Protein S Deficiency

Articles related to Protein S Deficiency:

(showing 540, show less)
# Title Authors Year
1
Recurrent strokes, central nervous system vasculitis, and acquired protein S deficiency secondary to varicella zoster in a child with AIDS. ( 30478796 )
2019
2
Venous Thromboembolism in a Young Girl with Duplication of the Inferior Vena Cava and Protein S Deficiency ( 30651208 )
2019
3
Clinical Manifestation and Mutation Spectrum of 53 Unrelated Pedigrees with Protein S Deficiency in China. ( 30669159 )
2019
4
Acquired Protein S Deficiency in a Patient with Lupus Nephritis. ( 30787859 )
2019
5
Protein S deficiency revealed by skin necrosis in a patient with lupus. ( 31018760 )
2019
6
Recurrent venous thrombosis during direct oral anticoagulant therapy in a patient with protein S deficiency. ( 31064935 )
2019
7
Nontraumatic Compartment Syndrome in a Patient with Protein S Deficiency: A Case Report. ( 30601765 )
2018
8
Recurrent esophagogastric variceal bleeding due to portal vein thrombosis caused by protein S deficiency. ( 30410946 )
2018
9
Rivaroxaban Causes Missed Diagnosis of Protein S Deficiency but Not of Activated Protein C Resistance (Factor V Leiden). ( 28920711 )
2018
10
Extensive Necrotic Skin Lesions Due to Post-varicella Protein S Deficiency. ( 29341982 )
2018
11
Preventative management against thromboembolism using fresh frozen plasma in a coronary artery bypass graft patient with protein S deficiency: a case report. ( 29492451 )
2018
12
Preliminary Data From the Study of Coagulative Profile of HIV Infected Individuals Suggest a Role For Point Mutations in the Gene in Protein S Deficiency in Individuals Undergoing Highly Antiretroviral Therapy. ( 29576814 )
2018
13
Rivaroxaban Treatment for Warfarin-Refractory Thrombosis in a Patient with Hereditary Protein S Deficiency. ( 29607227 )
2018
14
Recurrent pulmonary embolism associated with deep venous thrombosis diagnosed as protein s deficiency owing to a novel mutation in PROS1: A case report. ( 29742732 )
2018
15
Protein S deficiency in patients from the French Basque Country with various thrombotic conditions: a rarer inherited trait in autochthonous individuals? ( 29802506 )
2018
16
Warfarin-induced skin necrosis in a patient with protein S deficiency. ( 30066782 )
2018
17
Umbilical Artery Thrombosis with Associated Acute and Severe Fetal Growth Restriction and Transient Severe Protein S Deficiency: Report of a Case with Prenatal Ultrasound Diagnosis Allowing for Timely Intervention and Good Outcome. ( 30112236 )
2018
18
Perioperative management of laparoscopic surgery in a patient with protein S deficiency complications: A case report. ( 30259674 )
2018
19
PROS1 IVS10+5G>A mutation causes hereditary protein S deficiency in a Chinese patient with pulmonary embolism and venous thromboembolism. ( 30543986 )
2018
20
Dangerous Headache: A Case of Dural Venous Sinus Thrombosis with Protein S Deficiency. ( 28274079 )
2017
21
Successful medical management of acute mesenteric ischemia due to superior mesenteric and portal vein thrombosis in a 27-year-old man with protein S deficiency: a case report. ( 29117862 )
2017
22
Birthweight in pregnant women with protein S deficiency treated with low-molecular-weight heparin: a retrospective cohort study. ( 27677928 )
2017
23
Genotypes and phenotypes of protein S deficiency in Thai children with thromboembolism. ( 27748013 )
2017
24
Livedoid vasculopathy and popliteal artery occlusion in a patient with protein S deficiency. ( 27774697 )
2017
25
Gene analysis of six cases of congenital protein S deficiency and functional analysis of protein S mutations (A139V, C449F, R451Q, C475F, A525V and D599TfsTer13). ( 28088608 )
2017
26
High prevalence of mental disorders in patients with inherited protein S deficiency: A case report series. ( 28189910 )
2017
27
Lupus protein-losing enteropathy patient with protein C and protein S deficiency-induced thrombosis: A case report with review of the literature. ( 28375198 )
2017
28
Native aortic valve thrombosis in patient with protein S deficiency. ( 28419228 )
2017
29
Identification of reference miRNAs in plasma useful for the study of oestrogen-responsive miRNAs associated with acquired Protein S deficiency in pregnancy. ( 28743297 )
2017
30
Venous thromboembolism associated with protein S deficiency due to Arg451* mutation in PROS1 gene: a case report and a literature review. ( 29321366 )
2017
31
Ertapenem-Induced Acute Interstitial Nephritis (AIN) in a Case of Protein S Deficiency and Factor V Leiden Mutation with Deep Vein Thrombosis. ( 27731567 )
2016
32
Antithrombotic prophylaxis in a patient with nephrotic syndrome and congenital protein S deficiency. ( 26928822 )
2016
33
A Case of Postinfectious Protein S Deficiency Masquerading as Henoch-Schönlein Purpura. ( 26063758 )
2016
34
PROS1 genotype phenotype relationships in a large cohort of adults with suspicion of inherited quantitative protein S deficiency. ( 26466767 )
2016
35
Thrombin generation and other coagulation parameters in a patient with homozygous congenital protein S deficiency on treatment with rivaroxaban. ( 26586461 )
2016
36
Retiform Purpura Associated With Protein S Deficiency. ( 26708564 )
2016
37
Protein S deficiency complicated pregnancy in women with recurrent pregnancy loss. ( 26941215 )
2016
38
Protein S testing in patients with protein S deficiency, factor V Leiden, and rivaroxaban by North American Specialized Coagulation Laboratories. ( 27075008 )
2016
39
Malignant isolated cortical vein thrombosis with type II protein S deficiency: a case report. ( 27193638 )
2016
40
Intraventricular Hemorrhage in a Term Neonate: Manifestation of Protein S Deficiency- A Case Report. ( 27252923 )
2016
41
Endothelial Nitric Oxide Synthase T-786C Mutation, Prothrombin Gene Mutation (G-20210-A) and Protein S Deficiency Could Lead to Myocardial Infarction in a Very Young Male Adult. ( 27275349 )
2016
42
Acquired protein S deficiency manifests as pulmonary embolism in early pregnancy: a case report. ( 27595759 )
2016
43
Low-molecular-weight-heparin can benefit women with recurrent pregnancy loss and sole protein S deficiency: a historical control cohort study from Taiwan. ( 27799851 )
2016
44
Successful penile reconstruction following prior arteriovenous loop thrombosis due to undiagnosed protein-S deficiency and exogenous testosterone. ( 27833295 )
2016
45
A novel PROS1 mutation, c.74dupA, was identified in a protein S deficiency family. ( 27846449 )
2016
46
Central retinal vein occlusion as a presenting feature in a young patient with protein S deficiency. ( 25331213 )
2015
47
Stent thrombosis caused by metal allergy complicated by protein S deficiency and heparin-induced thrombocytopenia: a case report and review of the literature. ( 26207097 )
2015
48
Recurrent Postoperative Spinal Epidural Hematoma in a Patient with Protein S Deficiency. ( 26236521 )
2015
49
Cerebral Venous Thrombosis, Protein S Deficiency and Pregnancy Triad:A Case Report. ( 28276047 )
2015
50
A novel nonsense mutation Tyr301* of PROS1 causing protein S deficiency. ( 25255242 )
2015
51
Role of protein S deficiency in children with venous thromboembolism. An observational international cohort study. ( 25272994 )
2015
52
Cerebral venous thrombosis in young adult with familial protein S deficiency. ( 25304012 )
2015
53
Late onset thrombosis in two Japanese patients with compound heterozygote protein S deficiency. ( 25868595 )
2015
54
Protein S deficiency present in a pregnant woman with dyspnea, abdominal pains, restlessness, agitation and hypofibrinogenemia. ( 25914811 )
2015
55
Hereditary protein S deficiency leads to ischemic stroke. ( 25997409 )
2015
56
Acute ST Elevated Myocardial Injury due to Coronary Thrombosis during Thoracic Endovascular Aortic Repair in Patient with Protein S Deficiency. ( 25469146 )
2014
57
Left ventricular "masses" in a patient with protein S deficiency and a recent myocardial infarction: evidence of intraventricular thrombi or a benign observation? ( 24011912 )
2014
58
Acquired pial and dural arteriovenous fistulae following superior sagittal sinus thrombosis in patients with protein S deficiency: a report of two cases. ( 24162240 )
2014
59
Heerlen polymorphism associated with type III protein S deficiency and factor V Leiden mutation in a Polish patient with deep vein thrombosis. ( 24365770 )
2014
60
Staphylococcal endocarditis as the first manifestation of heritable protein S deficiency in childhood. ( 24462440 )
2014
61
PROS1 mutations associated with protein S deficiency in Polish patients with residual vein obstruction on rivaroxaban therapy. ( 24507871 )
2014
62
Skin necrosis: a rare complication of protein S deficiency. ( 24600778 )
2014
63
Protein S deficiency and novel oral anticoagulants: an intriguing case. ( 24642006 )
2014
64
Successful management of acute mesenteric ischaemia in a pregnant woman with protein S deficiency. ( 24652435 )
2014
65
Rapidly progressive cognitive impairment in a patient with high flow dural arteriovenous fistulas, cerebral sinus thrombosis and protein S deficiency. ( 24736194 )
2014
66
The genomic architecture of the PROS1 gene underlying large tandem duplication mutation that causes thrombophilia from hereditary protein S deficiency. ( 24992033 )
2014
67
Coronary artery bypass grafting in a patient with protein S deficiency: perioperative implications. ( 24994735 )
2014
68
Asymptomatic type B right atrial thrombus in a case with protein S deficiency. ( 24994736 )
2014
69
Multiple abdominal veins thrombosis secondary to protein s deficiency - a case report. ( 25121018 )
2014
70
Protein S Deficiency and an Adult Case with Moyamoya Syndrome that Presented with Primary Intraventricular Haemorrhage. ( 25207193 )
2014
71
Skin necrosis complicated by warfarin-induced protein S deficiency. ( 25240306 )
2014
72
Coronary artery bypass grafting in 2 thrombophilic patients with protein s deficiency. ( 25611767 )
2014
73
Editorial comment: "coronary artery bypass grafting in 2 thrombophilic patients with protein s deficiency" and "fulminant intraoperative right heart and pulmonary artery thrombosis following prothrombin complex concentrate infusion after complex open heart surgery with cardiopulmonary bypass". ( 25611768 )
2014
74
Stroke in young with primary protein--S deficiency. ( 25906532 )
2014
75
Sepsis Causing Acquired Protein C and Protein S Deficiency. ( 26905558 )
2014
76
Protein C and protein S deficiency presenting as Budd-Chiari syndrome. ( 23751604 )
2013
77
Thyroid storm presenting as congestive heart failure and protein-S deficiency-induced biventricular and internal jugular venous thrombii. ( 24029205 )
2013
78
Streptococcus agalactiae infective endocarditis with large vegetation in a patient with underlying protein S deficiency. ( 23001489 )
2013
79
Deep vein thrombosis and pulmonary embolism in a child with diabetic ketoacidosis and protein s deficiency: a case report. ( 23306559 )
2013
80
Molecular basis of protein S deficiency in China. ( 23813890 )
2013
81
Reversible diencephalic dysfunction as presentation of deep cerebral venous thrombosis due to hyperhomocysteinemia and protein S deficiency: Documentation of a case. ( 23914104 )
2013
82
Protein C and protein S deficiency - practical diagnostic issues. ( 23986205 )
2013
83
Protein S deficiency and Heerlen polymorphism in a Polish patient with acute myocardial infarction and previous venous thromboembolism. ( 24119292 )
2013
84
Anticoagulant treatment with rivaroxaban in severe protein S deficiency. ( 24144709 )
2013
85
Omental gangrene and porto-mesenteric thrombosis in a patient of protein C and protein s deficiency. ( 24426632 )
2013
86
[Intravenous recombinant tissue plasminogen activator therapy in a 14-week pregnant woman with embolic stroke due to protein S deficiency]. ( 23524601 )
2013
87
Case of proximal calciphylaxis with protein S deficiency, successfully treated with multimodality therapy. ( 21972994 )
2012
88
Calciphylaxis induced by acquired protein S deficiency in a patient with multiple myeloma - effective treatment with low-molecular-weight heparin. ( 22551348 )
2012
89
Lateral sinus thrombosis and haemorrhagic ischemic stroke with protein S deficiency in a young. ( 24047030 )
2012
90
Levamisole-adulterated in cocaine causing agranulocytosis, vasculopathy, and acquired protein S deficiency. ( 21773730 )
2012
91
Protein S deficiency in a living liver donor. ( 22175543 )
2012
92
Genotype and laboratory and clinical phenotypes of protein s deficiency. ( 22261441 )
2012
93
Management of acute portomesenteric venous thrombosis induced by protein S deficiency: report of a case. ( 22484987 )
2012
94
Sneddon syndrome associated with Protein S deficiency. ( 22565458 )
2012
95
Small and large PROS1 deletions but no other types of rearrangements detected in patients with protein S deficiency. ( 22627709 )
2012
96
Early recanalisation of cerebral venous sinus thrombosis in an unusual case associated with severe protein S deficiency. ( 22847569 )
2012
97
Isolated protein S deficiency presenting as catastrophic systemic arterial and subsequently venous thrombosis. ( 23024716 )
2012
98
TFPI resistance related to inherited or acquired protein S deficiency. ( 23079294 )
2012
99
Successful pregnancy outcome in a case of protein s deficiency. ( 24293862 )
2012
100
Inherited protein S deficiency due to a novel nonsense mutation in the PROS1 gene in the patient with recurrent vascular access thrombosis: A case report. ( 26889411 )
2012
101
Headache and aphasia in a young woman with protein S deficiency and nephrotic syndrome. ( 22649897 )
2011
102
Penile necrosis due to priapism developed after circumcision in a patient with protein S deficiency. ( 21810192 )
2011
103
Acute thrombosis of the superior mesenteric artery in a 39-year-old woman with protein-S deficiency: a case report. ( 21244677 )
2011
104
Mesenteric venous thrombosis in a child with type 2 protein S deficiency. ( 21285903 )
2011
105
Deep vein thrombosis associated with protein C and protein S deficiency: an unusual cause of acute abdomen. ( 21547930 )
2011
106
The vascular adverse events of protein S deficiency: a case report. ( 21746800 )
2011
107
Protein S deficiency with a PROS1 gene mutation in a patient presenting with mesenteric venous thrombosis following total colectomy. ( 21799399 )
2011
108
Internal jugular vein thrombosis associated with venous hypoplasia and protein S deficiency revealed by ultrasonography. ( 21931986 )
2011
109
Spontaneous Carotid Cavernous Fistula in a Case with Protein S Deficiency that Newly Developed Ophthalmoplegia after Embolization. ( 22087212 )
2011
110
Massive pulmonary embolism arising from a bifid ovarian vein in a patient with protein S deficiency. ( 22113762 )
2011
111
A rare splicing mutation in the PROS1 gene of a Korean patient with type I hereditary protein S deficiency. ( 22166512 )
2011
112
Avascular necrosis of hip following combined protein C and protein S deficiency. ( 22253170 )
2011
113
Protein S deficiency in a case of superor sagital vein thrombosis. ( 23134945 )
2011
114
Post varicella disseminated intravascular coagulation and transient protein S deficiency in an otherwise healthy 6-year-old boy: a case report. ( 20844918 )
2010
115
Postvaricella purpura fulminans with no evidence of disseminated intravascular coagulation (DIC) or protein S deficiency. ( 21404754 )
2010
116
Mesenteric ischemia and protein S deficiency: a rare case report. ( 18180128 )
2010
117
Novel human pathological mutations. Gene symbol: PROS1. Disease: Protein S deficiency. ( 20108435 )
2010
118
Altered reference ranges for protein C and protein S during early pregnancy: Implications for the diagnosis of protein C and protein S deficiency during pregnancy. ( 20174758 )
2010
119
Protein C and protein S deficiency presenting as deep venous thrombosis. ( 20228434 )
2010
120
Severe arterial thrombosis in a family with type III protein S deficiency caused by a frameshift mutation in the PROS1 gene. ( 20398916 )
2010
121
Similar hypercoagulable state and thrombosis risk in type I and type III protein S-deficient individuals from families with mixed type I/III protein S deficiency. ( 20421270 )
2010
122
Intracerebral mass bleeding in a term neonate: manifestation of hereditary protein S deficiency with a new mutation in the PROS1 gene. ( 20484936 )
2010
123
Postinfectious purpura fulminans secondary to varicella-induced protein S deficiency. ( 20520582 )
2010
124
Novel management of post varicella purpura fulminans owing to severe acquired protein S deficiency. ( 20625278 )
2010
125
Protein C and/or protein S deficiency and occurrence of stent thrombosis: a hitherto unrecognized association. ( 20825554 )
2010
126
Recurrent and consecutive non-arteritic optic neuropathy in a patient with protein S deficiency. ( 21135426 )
2010
127
Genetic predisposition of white matter infarction with protein S deficiency and R355C mutation. ( 21172841 )
2010
128
Deep vein thrombosis in protein S deficiency. ( 21180223 )
2010
129
The management of depression during pregnancy: a report from the American Psychiatric Association and the American College of Obstetricians and Gynecologists. ( 20027064 )
2010
130
Acquired protein S deficiency leads to obliterative portal venopathy and to compensatory nodular regenerative hyperplasia in HIV-infected patients. ( 19512859 )
2009
131
Extrahepatic portal hypertension due to familial protein S deficiency. ( 19179724 )
2009
132
Deep venous thrombosis related to protein S deficiency revealing celiac disease. ( 19098891 )
2009
133
Hereditary protein S deficiency from a novel large deletion mutation of the PROS1 gene detected by multiplex ligation-dependent probe amplification (MLPA). ( 19168201 )
2009
134
First case of protein S deficiency due to a translocation t(3;21)(q11.2;q22). ( 19404554 )
2009
135
Gross deletions/duplications in PROS1 are relatively common in point mutation-negative hereditary protein S deficiency. ( 19466456 )
2009
136
Nonbacterial purpura fulminans and severe autoimmune acquired protein S deficiency associated with human herpesvirus-6 active replication. ( 19545295 )
2009
137
Acute renal vein thrombosis, oral contraceptives, and protein S deficiency: a successful catheter-directed thrombolysis. ( 19631501 )
2009
138
Acute mesenteric venous thrombosis due to protein S deficiency in a pregnant woman. ( 19751348 )
2009
139
Compound heterozygous mutations in the PROS1 gene responsible for quantitative and qualitative protein S deficiency. ( 19826897 )
2009
140
Protein S deficiency: Recurrent ischemic stroke in young. ( 20174500 )
2009
141
TIPS can be lifesaving in acute liver failure associated with portal vein and inferior vena cava thrombosis in a case of Budd Chiari syndrome due to protein S deficiency. ( 18046604 )
2008
142
Recurrent priapism in sickle cell trait with protein S deficiency. ( 19157328 )
2008
143
Functional characterization of twelve natural PROS1 mutations associated with anticoagulant protein S deficiency. ( 18322254 )
2008
144
Protein S deficiency. ( 18379009 )
2008
145
Protein S deficiency, epileptic seizures, sagittal sinus thrombosis and hemorrhagic infarction after ingestion of dimenhydrinate. ( 18382986 )
2008
146
Late onset thrombosis in a case of severe protein S deficiency due to compound heterozygosity for PROS1 mutations. ( 18433462 )
2008
147
A case of hereditary protein S deficiency presenting with cerebral sinus venous thrombosis and deep vein thrombosis at high altitude. ( 18434709 )
2008
148
PROS1 analysis in 87 pedigrees with hereditary protein S deficiency demonstrates striking genotype-phenotype associations. ( 18435454 )
2008
149
Protein S deficiency: a clinical perspective. ( 18479427 )
2008
150
Severe protein S deficiency resulting from two novel mutations in PROS1 presenting with a relatively mild clinical phenotype. ( 18485091 )
2008
151
Inherited protein S deficiency as a result of a large duplication mutation of the PROS1 gene detected by multiplex ligation-dependent probe amplification. ( 18489710 )
2008
152
Confirmation of inherited protein S deficiency by PROS1 mutational screening: Identification of three novel PROS1 mutations and haplotype analysis of p.Q279X recurrence. ( 18841302 )
2008
153
Gene symbol: PROS1. Disease: Protein S deficiency. ( 18846658 )
2008
154
Gene symbol: PROS1. Disease: Protein S deficiency. ( 18846666 )
2008
155
Protein S deficiency manifesting simultaneously as central retinal artery occlusion, oculomotor nerve palsy, and systemic arterial occlusive diseases. ( 17259919 )
2007
156
Protein S deficiency with homozygous factor V Leiden mutation in central retinal vein occlusion. ( 17641719 )
2007
157
Central retinal vein occlusion secondary to protein S deficiency. ( 18025659 )
2007
158
Anticoagulant therapy after retinal vein occlusion in patients with protein S deficiency (Protein S deficiency with homozygous factor V Leiden mutation in central retinal vein occlusion. Vol. 42[4]). ( 18059510 )
2007
159
Protein S deficiency and lower-extremity arterial thrombosis: complicating a common presentation. ( 17369323 )
2007
160
Use of a functional assay to diagnose protein S deficiency; inappropriate testing yields equivocal results. ( 17535386 )
2007
161
An Sp1 binding site mutation of the PROS1 promoter in a patient with protein S deficiency. ( 17596203 )
2007
162
Pulmonary and deep vein thrombosis in a young patient with protein S deficiency: report of a case. ( 17643209 )
2007
163
Haemoperitoneum from corpus luteal rupture in a patient with protein S deficiency receiving anticoagulant therapy. ( 17713778 )
2007
164
Heparin-induced skin necrosis associated with thrombocytopenia and acquired protein C and protein S deficiency. ( 17722075 )
2007
165
Molecular basis of protein S deficiency. ( 17849042 )
2007
166
Treatment of massive cardiac thrombi in a patient with protein C and protein S deficiency. ( 17890961 )
2007
167
Unbalanced protein S deficiency due to warfarin treatment as a possible cause for thrombosis. ( 17897308 )
2007
168
A large deletion of the PROS1 gene in a deep vein thrombosis patient with protein S deficiency. ( 17938802 )
2007
169
Warfarin-induced skin necrosis and leukocytoclastic vasculitis in a patient with acquired protein C and protein S deficiency. ( 17982324 )
2007
170
Protein S deficiency and retinal arteriolar occlusion in pregnancy. ( 18050134 )
2007
171
Association of protein S p.Pro667Pro dimorphism with plasma protein S levels in normal individuals and patients with inherited protein S deficiency. ( 17157360 )
2007
172
Hemiconvulsion, hemiplegia, epilepsy syndrome and inherited protein S deficiency. ( 16514228 )
2006
173
Cardiopulmonary bypass for a coronary artery bypass graft patient with heterozygous protein C deficiency and protein S deficiency. ( 16615690 )
2006
174
Characterization of endoplasmic reticulum-associated degradation of a protein S mutant identified in a family of quantitative protein S deficiency. ( 15893367 )
2006
175
Molecular bases of type II protein S deficiency: the I203-D204 deletion in the EGF4 domain alters GLA domain function. ( 16409468 )
2006
176
Utility of thrombin-generation assay in the screening of factor V G1691A (Leiden) and prothrombin G20210A mutations and protein S deficiency. ( 16469858 )
2006
177
Testicular infarction secondary to protein S deficiency: a case report. ( 16827935 )
2006
178
One novel and one recurrent mutation in the PROS1 gene cause type I protein S deficiency in patients with pulmonary embolism associated with deep vein thrombosis. ( 16868938 )
2006
179
Identification of a novel PROS1 c.1113T-->GG frameshift mutation in a family with mixed type I/type III protein S deficiency. ( 16885060 )
2006
180
Intracardiac thrombus and pulmonary embolism with cavitation and pneumomediastinum in a patient with protein S deficiency. ( 16915068 )
2006
181
In vitro characterization of missense mutations associated with quantitative protein S deficiency. ( 16961607 )
2006
182
Thrombophilia in cardiac surgery--patients with protein S deficiency. ( 17126133 )
2006
183
Unusual thromboses associated with protein S deficiency in patients with acquired immunodeficiency syndrome: case reports and review of the literature. ( 16218798 )
2005
184
Alexia without agraphia following cerebral venous thrombosis associated with protein C and protein S deficiency. ( 16311147 )
2005
185
Molecular diversity and thrombotic risk in protein S deficiency: the PROSIT study. ( 15712227 )
2005
186
Difference in absolute risk of venous and arterial thrombosis between familial protein S deficiency type I and type III. Results from a family cohort study to assess the clinical impact of a laboratory test-based classification. ( 15725093 )
2005
187
Deep venous thrombosis, protein S deficiency and homozygous Factor XII 46T mutation. ( 15912386 )
2005
188
The incidence of venous thromboembolism in carriers of antithrombin, protein C or protein S deficiency associated with the HR2 haplotype of factor V: a family cohort study. ( 15978097 )
2005
189
Hemobilia in a patient with protein S deficiency after laparoscopic cholecystectomy that caused acute pancreatitis: successful endoscopic management. ( 15990843 )
2005
190
Protein S and congenital protein S deficiency: the most frequent congenital thrombophilia in Japanese. ( 16026279 )
2005
191
Bilateral internal jugular vein thrombosis in a child with protein S deficiency. ( 16102229 )
2005
192
Degos disease associated with protein S deficiency. ( 16120164 )
2005
193
HIV infection and stroke: if not protein S deficiency then what explains the relationship? ( 16170070 )
2005
194
Protein S deficiency in HIV associated ischaemic stroke: an epiphenomenon of HIV infection. ( 16170096 )
2005
195
Purpura fulminans as a sequel to erythema nodosum in a child with homozygous Leiden mutation and acquired protein S deficiency. ( 16188867 )
2005
196
Large deletions of the PROS1 gene in a large fraction of mutation-negative patients with protein S deficiency. ( 16363235 )
2005
197
Protein S deficiency is common in a healthy Thai population. ( 16623037 )
2005
198
[Retinal vein branch occlusion and palsy of the N. abducens in protein S deficiency]. ( 15138794 )
2005
199
Warfarin skin necrosis associated with protein S deficiency and a mutation in the methylenetetrahydrofolate reductase gene. ( 14723717 )
2004
200
Bilateral pulmonary artery aneurysms with protein C and protein S deficiency in a patient with Behçet's disease. ( 15124944 )
2004
201
Prevalence of protein S deficiency in the Japanese general population: the Suita Study. ( 15140145 )
2004
202
The prevalence of, and molecular defects underlying, inherited protein S deficiency in the general population. ( 15147381 )
2004
203
Association between the acquired free protein S deficiency in HIV-infected patients with the lipid profile levels. ( 15219212 )
2004
204
Identification of protein Salpha gene mutations including four novel mutations in eight unrelated patients with protein S deficiency. ( 15238143 )
2004
205
A life-threatening second trimester disseminated intravascular coagulopathy with protein s deficiency. ( 15247990 )
2004
206
A case of warfarin skin necrosis despite enoxaparin anticoagulation in a patient with protein S deficiency. ( 15253263 )
2004
207
Central retinal vein prethrombosis as an initial manifestation of protein S deficiency. ( 15448814 )
2004
208
Portal and mesenteric vein thrombosis after portal vein embolization in a patient with protein S deficiency. ( 15549434 )
2004
209
Co-segregation of the PROS1 locus and protein S deficiency in families having no detectable mutations in PROS1. ( 15550022 )
2004
210
Protein S deficiency associated with progressive loss of vision and intracranial venous sinus thrombosis. ( 15648287 )
2004
211
Protein S deficiency in the presence of weak lupus anticoagulant resulting in right ventricular thrombosis. ( 16166949 )
2004
212
Graves' disease associated with anticardiolipin antibody positivity and acquired protein S deficiency. ( 12856147 )
2003
213
Hereditary protein s deficiency with a history of recurrent myocardial infarction. ( 12548002 )
2003
214
Protein S deficiency in repetitive superficial thrombophlebitis. ( 12643325 )
2003
215
Inherited protein S deficiency: from genotype to phenotype. ( 12681962 )
2003
216
A novel G-to-A mutation in the intron-N of the protein S gene leading to abnormal RNA splicing in a patient with protein S deficiency. ( 12681974 )
2003
217
Severe protein S deficiency associated with heterozygous factor V Leiden mutation in a child with purpura fulminans. ( 12687747 )
2003
218
Diagnosing protein S deficiency: analytical considerations. ( 12705691 )
2003
219
Combined protein C and protein S deficiency in a family with repetitive thromboembolism and segregated gene mutations. ( 12705793 )
2003
220
Deep venous thrombosis associated with factor V Leiden, G20210A mutation, and protein S deficiency. ( 12714139 )
2003
221
Combination of congenital coagulation disorders: Factor II gene mutation G20210A, Factor V Leiden gene mutation G1691A and protein S deficiency. a family study. ( 12801853 )
2003
222
Sensitivity of functional protein S assays to protein S deficiency: a comparative study of three commercial kits. ( 12871384 )
2003
223
Acquired protein S deficiency in thrombotic thrombocytopenic purpura patients receiving solvent/detergent plasma exchange. ( 12877681 )
2003
224
Protein S deficiency presenting as deep vein thrombosis--a case report. ( 14565637 )
2003
225
Anaesthetic management of the parturient with protein S deficiency and lumboperitoneal shunt. ( 14601283 )
2003
226
Acquired protein C and protein S deficiency in HIV-infected patients. ( 14653442 )
2003
227
Pseudo-protein S deficiency due to activated protein C resistance. ( 15041281 )
2003
228
Normal functional protein S activity does not exclude protein S deficiency. ( 15583450 )
2003
229
Cutaneous necrosis revealing the coexistence of an antiphospholipid syndrome with acquired protein S deficiency, factor V Leiden and hyperhomocysteinemia. ( 11978573 )
2002
230
Dural arteriovenous fistula after craniotomy for pilocytic astrocytoma in a patient with protein S deficiency. ( 12361657 )
2002
231
Calciphylaxis in a patient with rheumatoid arthritis without renal failure and hyperparathyroidism: the possible role of long-term steroid use and protein S deficiency. ( 11954890 )
2002
232
Genetic and phenotypic variability between families with hereditary protein S deficiency. ( 11858485 )
2002
233
Recurrent pulmonary embolism in a 13-year-old male homozygous for the prothrombin G20210A mutation combined with protein S deficiency and increased lipoprotein (a). ( 11864707 )
2002
234
Cerebral venous thrombosis due to protein S deficiency in pregnancy. ( 11897316 )
2002
235
Four missense mutations identified in the protein S gene of thrombosis patients with protein S deficiency: effects on secretion and anticoagulant activity of protein S. ( 11927129 )
2002
236
Thromboplastin-thrombomodulin-mediated time: a new global test sensitive to protein S deficiency and increased levels of factors II, V, VII and X. ( 11940486 )
2002
237
Deep venous thrombosis associated with pulmonary tuberculosis and transient protein S deficiency. ( 12069029 )
2002
238
Protein S gene mutation in a young woman with type III protein S deficiency and venous thrombosis during pregnancy. ( 12101385 )
2002
239
Postvaricella purpura fulminans caused by acquired protein s deficiency resulting from antiprotein s antibodies: search for the epitopes. ( 12142795 )
2002
240
Protein S deficiency. Description of a case associated with chronic inflammatory bowel disease. ( 12207201 )
2002
241
Inferior vena caval thrombosis with sickle cell disease and heterozygous protein s deficiency. ( 12218606 )
2002
242
Protein S Gla-domain mutations causing impaired Ca(2+)-induced phospholipid binding and severe functional protein S deficiency. ( 12351389 )
2002
243
The association of Mondor's disease with protein S deficiency: case report and review of literature. ( 12355037 )
2002
244
Necrosis of the toe resulting from protein-s deficiency. ( 12409796 )
2002
245
Serendipitous diagnosis of protein S deficiency. ( 12416779 )
2002
246
Protein S deficiency manifesting as spontaneous aortic thrombosis in a neonate. ( 12793929 )
2002
247
Anterior spinal artery syndrome in an adolescent with protein S deficiency. ( 11292220 )
2001
248
Lupus anticoagulant and protein S deficiency in a child who developed disseminated intravascular coagulation in association with varicella. ( 11432493 )
2001
249
Heparin-induced skin necrosis in a patient with end-stage renal failure and functional protein S deficiency. ( 11509800 )
2001
250
Bilateral lower extremity thrombosis in a patient with protein S deficiency. ( 11192046 )
2001
251
Idiopathic pylephlebitis and idiopathic sclerosing peritonitis in a man with protein S deficiency. ( 11246360 )
2001
252
Testicular infarction associated with protein S deficiency. ( 11257684 )
2001
253
A novel splice acceptor site mutation of protein S gene in affected individuals with type I protein S deficiency: allelic exclusion of the mutant gene. ( 11297755 )
2001
254
Unusual retinal vasculitis in a patient with protein S deficiency and systemic toxoplasmosis: a case report. ( 11344718 )
2001
255
Failure in the detection of aberrant mRNA from the heterozygotic splice site mutant allele for protein S in a patient with protein S deficiency. ( 11369411 )
2001
256
DNA sequence analysis of protein S deficiency--identification of four point mutations in twelve Japanese subjects. ( 11372770 )
2001
257
Internal jugular vein thrombosis following in-vitro fertilization in a woman with protein S deficiency and heterozygosity for the prothrombin 3' UTR mutation, despite anticoagulation with heparin. ( 11555702 )
2001
258
Warfarin-induced skin necrosis associated with Factor V Leiden and protein S deficiency. ( 11683790 )
2001
259
Idiopathic osteonecrosis in an adult with familial protein S deficiency and hyperhomocysteinemia. ( 11685042 )
2001
260
An intraoperative coronary artery bypass graft thrombosis in a patient with protein S deficiency. ( 11748542 )
2001
261
Analytical considerations for free protein S assays in protein S deficiency. ( 11816698 )
2001
262
Hereditary protein S deficiency associated with rheumatoid arthritis: a case report of pulmonary embolism after total hip arthroplasty. ( 24383778 )
2001
263
[Protein S deficiency in three patients with thrombosis]. ( 11579499 )
2001
264
Severe acquired functional protein S deficiency and skin necrosis in a patient with ANCA-associated vasculitis. ( 11127886 )
2000
265
Hereditary haemorrhagic telangiectasia with protein S deficiency in a family: a case report. ( 10680707 )
2000
266
Sagittal sinus thrombosis associated with transient free protein S deficiency after L-asparaginase treatment: case report and review of the literature. ( 10717401 )
2000
267
Cardiac operation in a patient with combined homozygous protein C and protein S deficiency. ( 10794341 )
2000
268
Spontaneous superior mesenteric vein thrombosis (SMVT) in primary protein S deficiency. A case report and review of the literature. ( 10832545 )
2000
269
Detection of protein S deficiency: a new functional assay compared to an antigenic technique. ( 10840827 )
2000
270
Recurrent venous thrombosis in a patient with chronic lymphocytic leukemia and acquired protein S deficiency. ( 10841326 )
2000
271
The A20210 allele in the prothrombin gene enhances the risk of venous thrombosis in carriers of inherited protein S deficiency. ( 10847418 )
2000
272
Moyamoya syndrome with protein S deficiency. ( 11008263 )
2000
273
Lupus anticoagulant and protein S deficiency in otherwise healthy children with acute varicella infection. ( 11083373 )
2000
274
Protein S deficiency: a database of mutations--summary of the first update. ( 11127877 )
2000
275
Frequency of protein S deficiency in general Japanese population. ( 11150577 )
2000
276
Thrombophilia and dental surgery: a report of dental extraction in a patient with protein S deficiency. ( 11218468 )
2000
277
Renal biopsy precipitating catastrophic antiphospholipid syndrome, complicated by protein S deficiency and acute adrenal failure. ( 10200832 )
1999
278
Inherited protein C deficiency, protein S deficiency and hyperhomocysteinaemia in a patient with hereditary spherocytosis. ( 10448604 )
1999
279
Anesthetic management of the parturient with protein S deficiency and ischemic heart disease. ( 10475310 )
1999
280
Mesenteric and portal vein thrombosis in a young patient with protein S deficiency treated with urokinase via the superior mesenteric artery. ( 10477649 )
1999
281
Combination of APC resistance and acquired protein S deficiency in a haemodialysis patient with recurrent A-V shunt thrombosis. ( 10528677 )
1999
282
Intermittent left coronary occlusion caused by native aortic valve thrombosis in a patient with protein S deficiency. ( 10588791 )
1999
283
Mesenteric vein thrombosis secondary to protein S deficiency. ( 10606328 )
1999
284
Poor relationship between phenotypes of protein S deficiency and mutations in the protein S alpha gene. ( 10613647 )
1999
285
Protein C and protein S deficiency associated with retinal, optic nerve, and cerebral ischaemia. ( 10636660 )
1999
286
Dural sinus thrombosis in a patient with protein S deficiency--case report. ( 10658454 )
1999
287
Protein S deficiency, activated protein C resistance and sticky platelet syndrome in a young woman with bilateral strokes. ( 9973658 )
1999
288
Compound heterozygosity for one novel and one recurrent mutation in a Thai patient with severe protein S deficiency. ( 10063989 )
1999
289
Protein S deficiency presenting as an acute postoperative arterial thrombosis in a four-year-old child. ( 10072001 )
1999
290
Risk of venous thromboembolism and clinical manifestations in carriers of antithrombin, protein C, protein S deficiency, or activated protein C resistance: a multicenter collaborative family study. ( 10195932 )
1999
291
Severe cerebral venous sinus thrombosis and dural arteriovenous fistula in an infant with protein S deficiency. ( 10230669 )
1999
292
Myocardial infarction and death after caesarean section in a woman with protein S deficiency and undiagnosed phaeochromocytoma. ( 10234500 )
1999
293
Acquired protein S deficiency with multiple thrombotic complications after orthotopic liver transplant. ( 10360592 )
1999
294
Vitreoretinal findings similar to retinopathy of prematurity in infants with compound heterozygous protein S deficiency. ( 10442899 )
1999
295
A novel splice acceptor site mutation which produces multiple splicing abnormalities resulting in protein S deficiency type I. ( 10456456 )
1999
296
Mesenteric venous thrombosis in protein S deficiency: case report and literature review. ( 10489811 )
1999
297
Hormonal state rather than age influences cut-off values of protein S: reevaluation of the thrombotic risk associated with protein S deficiency. ( 10494769 )
1999
298
Cardiac transplantation in a patient with protein S deficiency. ( 10510018 )
1999
299
Acquired protein S deficiency caused by estrogen treatment of tall stature. ( 10518082 )
1999
300
Analysis of the protein s gene in protein s deficiency. ( 21341001 )
1999
301
Protein S gene analysis reveals the presence of a cosegregating mutation in most pedigrees with type I but not type III PS deficiency. ( 10447256 )
1999
302
Protein S deficiency and factor V Leiden gene in pregnancy. ( 15512044 )
1998
303
Clarification of the risk for venous thrombosis associated with hereditary protein S deficiency by investigation of a large kindred with a characterized gene defect. ( 9424998 )
1998
304
The A20210 allele of the prothrombin gene is frequently associated with the factor V Arg 506 to Gln mutation but not with protein S deficiency in thrombophilic families. ( 9490712 )
1998
305
Protein S deficiency: different biological phenotypes according to the assays used. ( 9493608 )
1998
306
Coexistence of primary antiphospholipid syndrome and protein S deficiency in a Hispanic man with ischemic stroke. ( 9521377 )
1998
307
Spontaneous tibial artery thrombosis associated with varicella pneumonia and free protein S deficiency. ( 9546247 )
1998
308
A common 4G allele in the promoter of the plasminogen activator inhibitor-1 (PAI-1) gene as a risk factor for pulmonary embolism and arterial thrombosis in hereditary protein S deficiency. ( 9569196 )
1998
309
Severe preeclampsia associated with coinheritance of factor V Leiden mutation and protein S deficiency. ( 9572171 )
1998
310
Lack of sequence variations in the C4b-BP beta-chain in patients with type III protein S deficiency bearing the Ser 460 to Pro mutation: description of two new intragenic isomorphisms in the C4b-BP beta-chain gene (C4BPB). ( 9576175 )
1998
311
Intracranial venous and dural sinus thrombosis due to protein S deficiency in a patient with AIDS. ( 9598696 )
1998
312
Cerebral venous thrombosis in pregnancy: the role of protein S deficiency. ( 9606438 )
1998
313
Coagulation activation in patients with an inflammatory syndrome: is there a link with acquired protein S deficiency? ( 9622214 )
1998
314
Three novel missense mutations in unrelated Japanese patients with type I and type II protein S deficiency and venous thrombosis. ( 9651142 )
1998
315
A novel mutation in intron K of the PROS1 gene causes aberrant RNA splicing and is a common cause of protein S deficiency in a UK thrombophilia cohort. ( 9657428 )
1998
316
Varicella purpura fulminans associated with heterozygosity for factor V leiden and transient protein S deficiency. ( 9794956 )
1998
317
Association between acquired free protein S deficiency, anticardiolipin antibodies, and thrombotic events in rheumatoid arthritis. ( 9818679 )
1998
318
Recurrent arterial thrombotic disease on young onset and protein S deficiency. ( 9863720 )
1998
319
Recurrent warfarin-induced skin necrosis in kindreds with protein S deficiency. ( 9885367 )
1998
320
Cerebral venous thrombosis as a complication of ulcerative colitis associated with protein-S deficiency: case report and review of literature. ( 19864785 )
1998
321
Coronary thrombosis associated with inherited protein S deficiency: a case report. ( 9013223 )
1997
322
Purpura fulminans induced by disseminated intravascular coagulation following infection in 2 unrelated children with double heterozygosity for factor V Leiden and protein S deficiency. ( 9241737 )
1997
323
Warfarin skin necrosis in a postpartum woman with protein S deficiency. ( 11770590 )
1997
324
Two distinct novel splice site mutations in a compound heterozygous patient with protein S deficiency. ( 9031442 )
1997
325
Identification of three novel mutations in hereditary protein S deficiency. ( 9031443 )
1997
326
Hereditary type IIb protein S deficiency in a patient with recurrent venous ulcers. ( 9094481 )
1997
327
Absence of linkage between type III protein S deficiency and the PROS1 and C4BP genes in families carrying the protein S Heerlen allele. ( 9108398 )
1997
328
Venous thrombosis after caesarean section in a young woman with homozygous APC resistance and type I protein S deficiency. ( 9111596 )
1997
329
Chronic leg ulcers associated with hereditary protein S deficiency. ( 9159008 )
1997
330
Successful pregnancy outcome in a patient with both congenital hypofibrinogenemia and protein S deficiency. ( 9166352 )
1997
331
Cutaneous heparin necrosis in a patient with heterozygous protein S deficiency. ( 9169261 )
1997
332
Protein S deficiency and antibodies to protein S in patients with Behçet's disease. ( 9175241 )
1997
333
A 41-year-old woman with protein S deficiency and diffuse proliferative lupus nephritis: is protein S deficiency associated with a hyperinflammatory response? ( 9186080 )
1997
334
Protein S deficiency. ( 9198178 )
1997
335
Familial heterozygous protein-S deficiency in a patient who had multifocal osteonecrosis. A case report. ( 9234887 )
1997
336
Protein S deficiency: a database of mutations. For the Plasma Coagulation Inhibitors Subcommittee of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis. ( 9241758 )
1997
337
High prevalence of antithrombin III, protein C and protein S deficiency, but no factor V Leiden mutation in venous thrombophilic Chinese patients in Taiwan. ( 9271815 )
1997
338
Efficacy of danazol in a patient with congenital protein-S deficiency: paradoxical evidence for decreased platelet activation with increased thrombin generation. ( 9306621 )
1997
339
A family of protein S deficiency including two adults with homozygous deficiency. ( 9308771 )
1997
340
Moyamoya disease and protein S deficiency: a case report. ( 9367301 )
1997
341
A hitherto unknown splice site defect in the protein S gene (PROS1): the mutation results in allelic exclusion and causes type I and type III protein S deficiency. ( 9375743 )
1997
342
Hyperhomocysteinaemia and protein S deficiency in complicated pregnancies. ( 9386024 )
1997
343
Free protein S deficiency is a risk factor for venous thrombosis. ( 9408016 )
1997
344
Acquired protein S deficiency, likely due to anti-PS autoantibodies, following a thrombotic event in a patient with a systemic lupus erythematosus. ( 9408030 )
1997
345
Protein S deficiency and pregnancy: is there a case for ylaxis? ( 9450361 )
1997
346
Identification of two different mutations causing protein S deficiency in two unrelated Belgian families using a nonisotopic scanning and sequencing method. ( 9690481 )
1997
347
Peripheral arterial thrombosis in systemic lupus erythematosis and nephrotic syndrome: possible association with protein S deficiency. ( 10868207 )
1997
348
Protein S deficiency in brain infarction of unknown cause. ( 12521095 )
1997
349
[Cerebral sinus thrombosis in a patient with protein S deficiency: a case report]. ( 9145407 )
1997
350
Calciphylaxis in a haemodialysis patient: functional protein S deficiency? ( 8918640 )
1996
351
Autoimmune protein S deficiency and deep vein thrombosis after chickenpox. ( 8713804 )
1996
352
Cutaneous T-cell lymphoma, tropical spastic paraparesis, cerebral vasculitis, and protein S deficiency in a patient with HTLV-I. ( 8865796 )
1996
353
Superior sagittal sinus thrombosis and acquired free protein S deficiency in the elderly. ( 8571436 )
1996
354
Acquired free protein S deficiency associated with multiple myeloma: a case report. ( 8602634 )
1996
355
Characterization of a large chromosomal deletion in the PROS1 gene of a patient with protein S deficiency type I using long PCR. ( 8616098 )
1996
356
The accurate definition of protein S deficiency may avoid the misestimation of the frequency of this defect. ( 8630429 )
1996
357
Cerebral and vein thrombosis, transient protein S deficiency, and anticardiolipin antibodies. ( 8638627 )
1996
358
Molecular basis of a hereditary type I protein S deficiency caused by a substitution of Cys for Arg474. ( 8639833 )
1996
359
Thrombotic risk in hereditary antithrombin III, protein C, or protein S deficiency. A cooperative, retrospective study. Gesellschaft fur Thrombose- und Hamostaseforschung (GTH) Study Group on Natural Inhibitors. ( 8640401 )
1996
360
Acquired free protein S deficiency in children with steroid resistant nephrosis. ( 8726222 )
1996
361
Inhibition of protein S by autoantibodies in patients with acquired protein S deficiency. ( 8743177 )
1996
362
Short-segment jejunal stenosis complicating subacute portomesenteric venous thrombosis in a patient with protein S deficiency type II. ( 8759683 )
1996
363
Protein S deficiency after varicella. ( 8765638 )
1996
364
Lupus anticoagulant and protein S deficiency in children with postvaricella purpura fulminans or thrombosis. ( 8774497 )
1996
365
Molecular basis of protein S deficiency in three families also showing independent inheritance of factor V leiden. ( 8781426 )
1996
366
Elevated levels of prothrombin activation fragment 1 + 2 in plasma from patients with heterozygous Arg506 to Gln mutation in the factor V gene (APC-resistance) and/or inherited protein S deficiency. ( 8815575 )
1996
367
New direct assay of free protein S antigen applied to diagnosis of protein S deficiency. ( 8815577 )
1996
368
Early coronary artery bypass graft thrombosis in a patient with protein S deficiency. ( 8817147 )
1996
369
Acquired protein S deficiency in children infected with human immunodeficiency virus. ( 8822281 )
1996
370
A novel nonsense mutation associated with an exon skipping in a patient with hereditary protein S deficiency type I. ( 8822579 )
1996
371
First case of sporadic protein S deficiency due to a novel candidate mutation, Ala 484-->Pro, in the protein S active gene (PROS1). ( 8822580 )
1996
372
Analysis for heterozygosity of protein S mRNA: application to genetic screening and family studies in hereditary protein S deficiency. ( 8854569 )
1996
373
Coagulation activation and fibrinolytic imbalance in subjects with idiopathic antiphospholipid antibodies--a crucial role for acquired free protein S deficiency. ( 8865529 )
1996
374
Free protein S deficiency in hemodialysis patients due to vascular calcifications? ( 8893155 )
1996
375
Identification of 19 protein S gene mutations in patients with phenotypic protein S deficiency and thrombosis. Protein S Study Group. ( 8943854 )
1996
376
Free protein S deficiency may be found in patients with antiphospholipid antibodies who do not have systemic lupus erythematosus. ( 8950774 )
1996
377
Coronary artery bypass graft surgery in a patient with hereditary protein S deficiency. ( 8969401 )
1996
378
Homozygous protein S deficiency: 7-year follow-up. ( 8972044 )
1996
379
Identification of two novel point mutations in the human protein S gene associated with familial protein S deficiency and thrombosis. ( 8977443 )
1996
380
Familial thrombophilia: clinical and molecular analysis of Swedish families with inherited resistance to activated protein C or protein S deficiency. ( 8981666 )
1996
381
Thrombosis and protein S deficiency in HIV infection. ( 8982179 )
1996
382
Calciphylaxis in a chronic hemodialysis patient with protein S deficiency. ( 8546177 )
1995
383
Portal vein thrombosis caused by protein C and protein S deficiency associated with cytomegalovirus infection. ( 7699538 )
1995
384
Homozygous APC-resistance combined with inherited type I protein S deficiency in a young boy with severe thrombotic disease. ( 7482396 )
1995
385
Protein S mRNA in patients with protein S deficiency. ( 7482397 )
1995
386
Identification of eight point mutations in protein S deficiency type I--analysis of 15 pedigrees. ( 7482398 )
1995
387
Buerger's disease and protein S deficiency: successful treatment with prostacyclin. ( 7554568 )
1995
388
Protein S deficiency type I: identification of point mutations in 9 of 10 families. ( 7579449 )
1995
389
Failure of the synthetic androgen, danazol, to increase protein S levels and prevent thrombosis in a patient with severe protein S deficiency. ( 7607583 )
1995
390
Acquired protein S deficiency in a patient with systemic lupus erythematosus causing central retinal vein thrombosis. ( 7615865 )
1995
391
Cerebral venous thrombosis and acquired protein S deficiency: an uncommon cause of headache in systemic lupus erythematosus. ( 7633801 )
1995
392
Acquired free protein S deficiency is associated with antiphospholipid antibodies and increased thrombin generation in patients with systemic lupus erythematosus. ( 7709951 )
1995
393
Severe autoimmune protein S deficiency in a boy with idiopathic purpura fulminans. ( 7734361 )
1995
394
Evaluation of the relationship between protein S and C4b-binding protein isoforms in hereditary protein S deficiency demonstrating type I and type III deficiencies to be phenotypic variants of the same genetic disease. ( 7780139 )
1995
395
Clinically silent pulmonary embolism due to transient protein S deficiency. ( 8565357 )
1995
396
A quantitative protein S deficiency associated with a novel nonsense mutation and markedly reduced levels of mutated mRNA. ( 8584989 )
1995
397
Acquired protein S deficiency with primary antiphospholipid syndrome and recurrent thrombotic events: report of a case. ( 8869229 )
1995
398
Autoimmune protein S deficiency: a disorder predisposing to thrombosis. ( 7628763 )
1995
399
Caesarean section in a patient with protein S deficiency. ( 7717496 )
1995
400
Identification of 15 different candidate causal point mutations and three polymorphisms in 19 patients with protein S deficiency using a scanning method for the analysis of the protein S active gene. ( 7803790 )
1995
401
Anticardiolipin antibodies, functional protein S deficiency, and fetal loss. ( 7832202 )
1995
402
Transient protein S deficiency associated with cerebral venous thrombosis in active ulcerative colitis. ( 7847309 )
1995
403
[Molecular biological analysis of hereditary thrombophilia--genetic characterization of protein S deficiency]. ( 7783333 )
1995
404
Detection and characterization of seven novel protein S (PROS) gene lesions: evaluation of reverse transcript-polymerase chain reaction as a mutation screening strategy. ( 7545463 )
1995
405
[Thrombophilia in a family with resistance to activated protein C and protein S deficiency]. ( 8618815 )
1995
406
Cerebral ischemia in a patient with protein S deficiency and carotid stenosis. ( 8056555 )
1994
407
Further evidence that activated protein C resistance can be misdiagnosed as inherited functional protein S deficiency. ( 7803245 )
1994
408
Correlation of antiphospholipid antibodies and protein S deficiency with thrombosis in HIV-infected men. ( 7841299 )
1994
409
Thrombolysis in pulmonary embolism: an adolescent with protein S deficiency. ( 7847117 )
1994
410
Detection of protein C or protein S deficiency in patients on warfarin therapy--a study of nine patients. ( 7847765 )
1994
411
A case of nephrotic syndrome associated with protein S deficiency and cerebral thrombosis. ( 7848584 )
1994
412
Protein S deficiency: a case study. ( 7848865 )
1994
413
Inherited protein S deficiency: clinical manifestations and laboratory findings in 63 patients. ( 7863477 )
1994
414
Role of autoimmunity in protein S deficiency during HIV-1 infection. ( 7927817 )
1994
415
Childhood stroke associated with familial protein S deficiency. ( 7943612 )
1994
416
Massive acute pulmonary embolism in protein S deficiency--a case report. ( 7944258 )
1994
417
Anticardiolipin and acquired protein S deficiency in early childhood. ( 7946553 )
1994
418
Homozygous protein S deficiency due to a one base pair deletion that leads to a stop codon in exon III of the protein S gene. ( 7974339 )
1994
419
Coumarin-induced skin necrosis associated with acquired protein S deficiency and antiphospholipid antibody syndrome. ( 8024618 )
1994
420
Free protein S deficiency in patients with Crohn's disease. ( 8047807 )
1994
421
The risk of thromboembolism in asymptomatic patients with protein C and protein S deficiency: a prospective cohort study. ( 8052960 )
1994
422
Cutaneous necrosis associated with acquired severe protein S deficiency. ( 8068141 )
1994
423
Successful delayed thrombolysis with tissue plasminogen activator for recurrent arterial thrombosis secondary to protein S deficiency. ( 8088407 )
1994
424
Thrombotic risk of women with hereditary antithrombin III-, protein C- and protein S-deficiency taking oral contraceptive medication. The GTH Study Group on Natural Inhibitors. ( 8091378 )
1994
425
Three novel mutations in five unrelated subjects with hereditary protein S deficiency type I. ( 8113388 )
1994
426
Protein S deficiency in lupus erythematosus secondary to hereditary angio-oedema. ( 8148282 )
1994
427
Deep vein thrombosis in a 13-year-old boy with hereditary protein S deficiency and a review of the pediatric literature. ( 8178804 )
1994
428
Increased thrombosis incidence in a family with an inherited protein S deficiency and a high oxygen affinity hemoglobin variant. ( 8192151 )
1994
429
The perioperative management of protein S deficiency in total hip arthroplasty. ( 8194228 )
1994
430
Protein S Tokushima: abnormal molecule with a substitution of Glu for Lys-155 in the second epidermal growth factor-like domain of protein S. ( 8298131 )
1994
431
Acquired antithrombin III deficiency: replacement with antithrombin III concentrates in a patient with protein S deficiency accelerates response to therapy. ( 8291376 )
1993
432
Protein S deficiency in a patient with necrotizing cellulitis. ( 8403462 )
1993
433
Protein S deficiency associated to anti-protein S antibodies in a patient with mixed connective-tissue disease and its reversal by danazol. ( 8213003 )
1993
434
A case of portal vein thrombosis associated with protein S deficiency. ( 8409344 )
1993
435
Study of a protein S gene polymorphism at DNA and mRNA level in a family with symptomatic protein S deficiency. ( 7902733 )
1993
436
Cutaneous necrosis associated with acquired severe protein S deficiency. ( 8068053 )
1993
437
Acquired protein S deficiency. ( 8215536 )
1993
438
The clinical expression of hereditary protein C and protein S deficiency: a relation to clinical thrombotic risk factors and to levels of protein C and protein S? ( 8218852 )
1993
439
Caveats in diagnosing protein S deficiency. ( 8239970 )
1993
440
Autoimmune protein S deficiency. ( 8247052 )
1993
441
Protein S deficiency: imaging findings. ( 8249743 )
1993
442
Mesenteric venous thrombosis with protein S deficiency. ( 8250001 )
1993
443
Hereditary protein S deficiency in a large New Jersey kindred. ( 8264049 )
1993
444
Association of protein S deficiency with thrombosis in a kindred with increased levels of plasminogen activator inhibitor-1. ( 8379599 )
1993
445
Cutaneous necrosis resulting from protein S deficiency and increased antiphospholipid antibody in a patient with systemic lupus erythematosus. ( 8408826 )
1993
446
Acquired protein S deficiency. ( 8417170 )
1993
447
Mesenteric venous thrombosis in familial free protein S deficiency. ( 8420255 )
1993
448
Protein S deficiency in pregnancy: a case report. ( 8420317 )
1993
449
A case of cerebral infarction in association with free protein S deficiency and oral contraceptive use. ( 8420528 )
1993
450
Free protein S deficiency in acute ischemic stroke. A case-control study. ( 8421823 )
1993
451
Transient protein S deficiency with deep venous thrombosis during Salmonella typhimurium infection. ( 8435001 )
1993
452
Protein S deficiency in men with long-term human immunodeficiency virus infection. ( 8461466 )
1993
453
Brief report: autoimmune protein S deficiency in a boy with severe thromboembolic disease. ( 8497285 )
1993
454
[Hereditary protein S deficiency and familial thrombosis. A review with description of a Danish family with protein S deficiency]. ( 8317013 )
1993
455
Behçet syndrome associated with protein S deficiency. ( 1535461 )
1992
456
Purpura fulminans due to protein S deficiency following chickenpox. ( 1386247 )
1992
457
Protein C and protein S deficiency in thalassemic patients. ( 1298996 )
1992
458
Erythropoietin-induced protein S deficiency and vena cava thrombosis. ( 1328949 )
1992
459
Functional heredity protein S deficiency with arterial thrombosis. ( 1386500 )
1992
460
Acquired protein S deficiency. ( 1392420 )
1992
461
Recurrent cerebral thrombosis associated with protein S deficiency in a Chinese female. ( 1411682 )
1992
462
Intra-cardial thrombosis with systemic and pulmonary embolism as main symptoms in a patient with protein S deficiency. ( 1420826 )
1992
463
Warfarin-induced skin necrosis in 2 patients with protein S deficiency: successful reinstatement of warfarin therapy. ( 1427456 )
1992
464
Acquired protein S deficiency might be associated with a prethrombotic state during estrogen treatment for tall stature. ( 1440506 )
1992
465
Arterial thrombosis and protein S deficiency. ( 1447661 )
1992
466
Markers of coagulation activation in inherited protein S deficiency. ( 1448792 )
1992
467
Free protein S deficiency in patients with chronic inflammatory bowel disease. ( 1455194 )
1992
468
Superior sagittal sinus thrombosis in a child with protein S deficiency. ( 1461385 )
1992
469
Splenic rupture following splenic vein thrombosis in a man with protein S deficiency. ( 1494517 )
1992
470
Recurrent venous thrombosis during warfarin treatment related to acquired protein S deficiency. ( 1519231 )
1992
471
Protein S deficiency: early presentation and pulmonary hypertension. ( 1519965 )
1992
472
Hereditary protein S deficiency presenting with cerebral sinus thrombosis in an adolescent girl. ( 1532418 )
1992
473
Protein S deficiency and skin necrosis associated with continuous ambulatory peritoneal dialysis. ( 1532474 )
1992
474
Severe protein S deficiency in a newborn. ( 1532635 )
1992
475
Acquired protein S deficiency: correlation with advanced disease in HIV-1-infected patients. ( 1532830 )
1992
476
Stroke and familial protein S deficiency. ( 1532868 )
1992
477
Protein S deficiency in middle-aged women with stroke. ( 1533705 )
1992
478
Case report: a novel form of free protein S deficiency in an HIV-positive patient on hemodialysis. ( 1534966 )
1992
479
Cerebral sinus thrombosis in a patient with hereditary protein S deficiency: case report and review of the literature. ( 1554792 )
1992
480
Study of the protein S system in HIV-infected patients: acquired protein S deficiency or unsuitable assays? ( 1643207 )
1992
481
Protein S deficiency and bilateral branch retinal artery occlusion. ( 1827174 )
1991
482
Transient anticardiolipin antibodies, functional protein S deficiency, and deep vein thrombosis. ( 1825446 )
1991
483
Protein S deficiency and HIV infection. ( 1826342 )
1991
484
Inadequate antidiuretic hormone secretion after sagittal sinus thrombosis caused by protein S deficiency. ( 1829282 )
1991
485
Warfarin induced dermatitis and venous thrombosis in a patient with Protein S deficiency. ( 1830603 )
1991
486
Skin necrosis following prolonged administration of coumarin in a patient with inherited protein S deficiency. ( 1832815 )
1991
487
Molecular basis of hereditary protein C and protein S deficiency. ( 1835438 )
1991
488
Coumadin skin necrosis in a patient with a free protein S deficiency: case report and literature review. ( 1837041 )
1991
489
Congenital antithrombin III, protein C and protein S deficiency: a literature review with nursing implications. ( 1837732 )
1991
490
Deep venous thrombosis in a child with nephrotic syndrome associated with a circulating anticoagulant and acquired protein S deficiency. ( 1838904 )
1991
491
Protein S activity in patients with heredofamilial protein S deficiency and in patients with juvenile venous thrombosis. Results of a functional method. ( 1839200 )
1991
492
Protein S deficiency associated with central retinal artery occlusion. ( 2142417 )
1990
493
Neonatal purpura fulminans associated with homozygous protein S deficiency. ( 1967377 )
1990
494
Two ELISA's for measurement of protein S, and their use in the laboratory diagnosis of protein S deficiency. ( 2138066 )
1990
495
Possible role for increased C4b-binding-protein level in acquired protein S deficiency in type I diabetes. ( 2138576 )
1990
496
Superior sagittal sinus thrombosis in a patient with protein S deficiency. ( 2139256 )
1990
497
Bone mineral density and its association with inherited protein S deficiency. ( 2141197 )
1990
498
Screening of protein S deficiency using a functional assay in patients with venous and arterial thrombosis. ( 2142342 )
1990
499
Laboratory diagnosis of inherited protein S deficiency. ( 2142570 )
1990
500
Bilateral deep venous thrombosis in protein S deficiency. Detection by radionuclide venography. ( 2145111 )
1990
501
Free protein S deficiency in a family with venous thrombosis. ( 2146406 )
1990
502
Heterozygous protein-S deficiency: a study of a large kindred. ( 2147089 )
1990
503
Cerebral infarction and familial protein S deficiency. ( 2148233 )
1990
504
Hereditary protein S deficiency in young adults with arterial occlusive disease. ( 2148653 )
1990
505
Familial protein S deficiency presenting as deep vein thrombosis occurring during pregnancy. ( 2149488 )
1990
506
Cutaneous necrosis associated with protein S deficiency. ( 2149570 )
1990
507
Homozygous protein S deficiency in an infant with purpura fulminans. ( 2231208 )
1990
508
Type I protein S deficiency and skin necrosis. ( 2371192 )
1990
509
A mutation in the protein S pseudogene is linked to protein S deficiency in a thrombophilic family. ( 2531940 )
1989
510
Free protein S deficiency: a possible association with cerebrovascular occlusion. ( 2531944 )
1989
511
A new case of 'type II' inherited protein S deficiency. ( 2532929 )
1989
512
Severe arterial cerebral thrombosis in a patient with protein S deficiency (moderately reduced total and markedly reduced free protein S): a family study. ( 2526383 )
1989
513
Familial protein S deficiency with a variant protein S molecule in plasma and platelets. ( 2526663 )
1989
514
Acquired functional protein S deficiency, cerebral venous thrombosis, and coumarin skin necrosis in association with antiphospholipid syndrome: report of two cases. ( 2527005 )
1989
515
A Dutch family with hereditary protein S deficiency. ( 2528077 )
1989
516
Multiple arteriovenous malformations of the small intestine in a patient with protein S deficiency. ( 2528285 )
1989
517
Arterial thrombosis and protein S deficiency. ( 2531937 )
1989
518
Unexplained thromboembolism. When to suspect antithrombin III, protein C, or protein S deficiency. ( 2964003 )
1988
519
Protein S deficiency in sickle cell anemia. ( 2966224 )
1988
520
Thrombosis of the superior mesenteric vein in a patient with recurrent spontaneous venous thrombosis caused by familial protein S deficiency. ( 2966988 )
1988
521
Management of protein S deficiency. ( 2967360 )
1988
522
Deep venous thrombosis, inflammatory bowel disease, and protein S deficiency. ( 2972196 )
1988
523
Protein S deficiency. ( 2972267 )
1988
524
Familial type I protein S deficiency associated with severe venous thrombosis--a study of five cases. ( 2973153 )
1988
525
Mitral valve prolapse, cerebral ischemia, and protein S deficiency. ( 3364453 )
1988
526
Mesenteric vein thrombosis as presenting manifestation of hereditary protein S deficiency. ( 2946623 )
1987
527
Ulcer necrotic legs as first manifestation of protein S deficiency. ( 2950942 )
1987
528
Hereditary protein S deficiency: clinical manifestations. ( 2952034 )
1987
529
Protein S deficiency occurs in the nephrotic syndrome. ( 2954500 )
1987
530
Effectiveness of long term oral anticoagulation treatment in preventing venous thrombosis in hereditary protein S deficiency. ( 2959350 )
1987
531
Severe deep vein thrombosis in a 2-year-old child with protein S deficiency. ( 2965427 )
1987
532
Plasma protein S deficiency and thromboembolic disease. ( 2971986 )
1987
533
An abnormal plasma distribution of protein S occurs in functional protein S deficiency. ( 2935211 )
1986
534
Protein S deficiency in pregnancy. ( 2942036 )
1986
535
Protein S deficiency associated with "juvenile" arterial and venous thromboses. ( 2944242 )
1986
536
Mode of inheritance of type II protein S deficiency. ( 2946334 )
1986
537
Hereditary protein S deficiency. ( 2931333 )
1985
538
Hereditary protein S deficiency and venous thrombo-embolism. A study in three Dutch families. ( 3161207 )
1985
539
Plasma protein S deficiency in familial thrombotic disease. ( 6238642 )
1984
540
Familial protein S deficiency is associated with recurrent thrombosis. ( 6239877 )
1984

Variations for Protein S Deficiency

ClinVar genetic disease variations for Protein S Deficiency:

6 (showing 118, show less)
# Gene Variation Type Significance SNP ID Assembly Location
1 PROS1 NM_000313.3(PROS1): c.1501T> C (p.Ser501Pro) single nucleotide variant Conflicting interpretations of pathogenicity rs121918472 GRCh37 Chromosome 3, 93598150: 93598150
2 PROS1 NM_000313.3(PROS1): c.1501T> C (p.Ser501Pro) single nucleotide variant Conflicting interpretations of pathogenicity rs121918472 GRCh38 Chromosome 3, 93879306: 93879306
3 PROS1 NM_000313.3(PROS1): c.773A> G (p.Asn258Ser) single nucleotide variant Pathogenic rs121918473 GRCh37 Chromosome 3, 93617368: 93617368
4 PROS1 NM_000313.3(PROS1): c.773A> G (p.Asn258Ser) single nucleotide variant Pathogenic rs121918473 GRCh38 Chromosome 3, 93898524: 93898524
5 PROS1 NM_000313.3(PROS1): c.586A> G (p.Lys196Glu) single nucleotide variant Pathogenic rs121918474 GRCh37 Chromosome 3, 93624643: 93624643
6 PROS1 NM_000313.3(PROS1): c.586A> G (p.Lys196Glu) single nucleotide variant Pathogenic rs121918474 GRCh38 Chromosome 3, 93905799: 93905799
7 PROS1 PROS1, IVS10DS, G-A, +5 single nucleotide variant Pathogenic
8 PROS1 NM_000313.3(PROS1): c.2031A> T (p.Ter677Tyr) single nucleotide variant Pathogenic rs267606981 GRCh37 Chromosome 3, 93593089: 93593089
9 PROS1 NM_000313.3(PROS1): c.2031A> T (p.Ter677Tyr) single nucleotide variant Pathogenic rs267606981 GRCh38 Chromosome 3, 93874245: 93874245
10 PROS1 PROS1, IVS11AS, A-G, -9 single nucleotide variant Pathogenic
11 PROS1 NM_000313.3(PROS1): c.835C> T (p.Gln279Ter) single nucleotide variant Pathogenic rs121918475 GRCh37 Chromosome 3, 93617306: 93617306
12 PROS1 NM_000313.3(PROS1): c.835C> T (p.Gln279Ter) single nucleotide variant Pathogenic rs121918475 GRCh38 Chromosome 3, 93898462: 93898462
13 PROS1 NM_000313.3(PROS1): c.1681C> G (p.Arg561Gly) single nucleotide variant Pathogenic rs121918476 GRCh37 Chromosome 3, 93595999: 93595999
14 PROS1 NM_000313.3(PROS1): c.1681C> G (p.Arg561Gly) single nucleotide variant Pathogenic rs121918476 GRCh38 Chromosome 3, 93877155: 93877155
15 PROS1 NM_000313.3(PROS1): c.1063C> T (p.Arg355Cys) single nucleotide variant Pathogenic rs387906674 GRCh37 Chromosome 3, 93611869: 93611869
16 PROS1 NM_000313.3(PROS1): c.1063C> T (p.Arg355Cys) single nucleotide variant Pathogenic rs387906674 GRCh38 Chromosome 3, 93893025: 93893025
17 PROS1 NM_000313.3(PROS1): c.1747A> C (p.Asn583His) single nucleotide variant Uncertain significance rs139479630 GRCh38 Chromosome 3, 93877089: 93877089
18 PROS1 NM_000313.3(PROS1): c.1907A> G (p.Tyr636Cys) single nucleotide variant Uncertain significance rs368173480 GRCh37 Chromosome 3, 93593213: 93593213
19 PROS1 NM_000313.3(PROS1): c.1907A> G (p.Tyr636Cys) single nucleotide variant Uncertain significance rs368173480 GRCh38 Chromosome 3, 93874369: 93874369
20 PROS1 NM_000313.3(PROS1): c.1762A> G (p.Thr588Ala) single nucleotide variant Benign rs142846443 GRCh37 Chromosome 3, 93595918: 93595918
21 PROS1 NM_000313.3(PROS1): c.1762A> G (p.Thr588Ala) single nucleotide variant Benign rs142846443 GRCh38 Chromosome 3, 93877074: 93877074
22 PROS1 NM_000313.3(PROS1): c.1747A> C (p.Asn583His) single nucleotide variant Uncertain significance rs139479630 GRCh37 Chromosome 3, 93595933: 93595933
23 PROS1 NM_000313.3(PROS1): c.1594A> G (p.Thr532Ala) single nucleotide variant Uncertain significance rs371028997 GRCh37 Chromosome 3, 93598057: 93598057
24 PROS1 NM_000313.3(PROS1): c.1594A> G (p.Thr532Ala) single nucleotide variant Uncertain significance rs371028997 GRCh38 Chromosome 3, 93879213: 93879213
25 PROS1 NM_000313.3(PROS1): c.1528G> A (p.Val510Met) single nucleotide variant Benign rs138925964 GRCh37 Chromosome 3, 93598123: 93598123
26 PROS1 NM_000313.3(PROS1): c.1528G> A (p.Val510Met) single nucleotide variant Benign rs138925964 GRCh38 Chromosome 3, 93879279: 93879279
27 PROS1 NM_000313.3(PROS1): c.1331C> T (p.Pro444Leu) single nucleotide variant Uncertain significance rs369244777 GRCh37 Chromosome 3, 93603733: 93603733
28 PROS1 NM_000313.3(PROS1): c.1331C> T (p.Pro444Leu) single nucleotide variant Uncertain significance rs369244777 GRCh38 Chromosome 3, 93884889: 93884889
29 PROS1 NM_000313.3(PROS1): c.1095T> G (p.Asn365Lys) single nucleotide variant Uncertain significance rs199469491 GRCh37 Chromosome 3, 93611837: 93611837
30 PROS1 NM_000313.3(PROS1): c.1095T> G (p.Asn365Lys) single nucleotide variant Uncertain significance rs199469491 GRCh38 Chromosome 3, 93892993: 93892993
31 PROS1 NM_000313.3(PROS1): c.946C> T (p.Arg316Cys) single nucleotide variant Uncertain significance rs373983977 GRCh37 Chromosome 3, 93615439: 93615439
32 PROS1 NM_000313.3(PROS1): c.946C> T (p.Arg316Cys) single nucleotide variant Uncertain significance rs373983977 GRCh38 Chromosome 3, 93896595: 93896595
33 PROS1 NM_000313.3(PROS1): c.698G> A (p.Arg233Lys) single nucleotide variant Conflicting interpretations of pathogenicity rs41267007 GRCh37 Chromosome 3, 93619677: 93619677
34 PROS1 NM_000313.3(PROS1): c.698G> A (p.Arg233Lys) single nucleotide variant Conflicting interpretations of pathogenicity rs41267007 GRCh38 Chromosome 3, 93900833: 93900833
35 PROS1 NM_000313.3(PROS1): c.676T> A (p.Cys226Ser) single nucleotide variant Uncertain significance rs370855515 GRCh37 Chromosome 3, 93619699: 93619699
36 PROS1 NM_000313.3(PROS1): c.676T> A (p.Cys226Ser) single nucleotide variant Uncertain significance rs370855515 GRCh38 Chromosome 3, 93900855: 93900855
37 PROS1 NM_000313.3(PROS1): c.431C> A (p.Thr144Asn) single nucleotide variant Uncertain significance rs146366248 GRCh37 Chromosome 3, 93624903: 93624903
38 PROS1 NM_000313.3(PROS1): c.431C> A (p.Thr144Asn) single nucleotide variant Uncertain significance rs146366248 GRCh38 Chromosome 3, 93906059: 93906059
39 PROS1 NM_000313.3(PROS1): c.284G> A (p.Gly95Glu) single nucleotide variant Uncertain significance rs144526169 GRCh37 Chromosome 3, 93629525: 93629525
40 PROS1 NM_000313.3(PROS1): c.284G> A (p.Gly95Glu) single nucleotide variant Uncertain significance rs144526169 GRCh38 Chromosome 3, 93910681: 93910681
41 PROS1 NM_000313.3(PROS1): c.728-1G> A single nucleotide variant Likely pathogenic rs368074804 GRCh37 Chromosome 3, 93617414: 93617414
42 PROS1 NM_000313.3(PROS1): c.728-1G> A single nucleotide variant Likely pathogenic rs368074804 GRCh38 Chromosome 3, 93898570: 93898570
43 PROS1 NM_000313.3(PROS1): c.76+7A> G single nucleotide variant Conflicting interpretations of pathogenicity rs201928951 GRCh38 Chromosome 3, 93973667: 93973667
44 PROS1 NM_000313.3(PROS1): c.76+7A> G single nucleotide variant Conflicting interpretations of pathogenicity rs201928951 GRCh37 Chromosome 3, 93692511: 93692511
45 PROS1 NM_000313.3(PROS1): c.2001A> G (p.Pro667=) single nucleotide variant Benign/Likely benign rs6123 GRCh37 Chromosome 3, 93593119: 93593119
46 PROS1 NM_000313.3(PROS1): c.2001A> G (p.Pro667=) single nucleotide variant Benign/Likely benign rs6123 GRCh38 Chromosome 3, 93874275: 93874275
47 PROS1 NM_000313.3(PROS1): c.*197C> T single nucleotide variant Likely benign rs182088150 GRCh38 Chromosome 3, 93874048: 93874048
48 PROS1 NM_000313.3(PROS1): c.*197C> T single nucleotide variant Likely benign rs182088150 GRCh37 Chromosome 3, 93592892: 93592892
49 PROS1 NM_000313.3(PROS1): c.*155T> A single nucleotide variant Uncertain significance rs534064879 GRCh38 Chromosome 3, 93874090: 93874090
50 PROS1 NM_000313.3(PROS1): c.*155T> A single nucleotide variant Uncertain significance rs534064879 GRCh37 Chromosome 3, 93592934: 93592934
51 PROS1 NM_000313.3(PROS1): c.1377A> G (p.Gly459=) single nucleotide variant Conflicting interpretations of pathogenicity rs371312357 GRCh38 Chromosome 3, 93884843: 93884843
52 PROS1 NM_000313.3(PROS1): c.1377A> G (p.Gly459=) single nucleotide variant Conflicting interpretations of pathogenicity rs371312357 GRCh37 Chromosome 3, 93603687: 93603687
53 PROS1 NM_000313.3(PROS1): c.684C> T (p.Cys228=) single nucleotide variant Uncertain significance rs377173471 GRCh38 Chromosome 3, 93900847: 93900847
54 PROS1 NM_000313.3(PROS1): c.684C> T (p.Cys228=) single nucleotide variant Uncertain significance rs377173471 GRCh37 Chromosome 3, 93619691: 93619691
55 PROS1 NM_000313.3(PROS1): c.601+12A> G single nucleotide variant Uncertain significance rs753550053 GRCh38 Chromosome 3, 93905772: 93905772
56 PROS1 NM_000313.3(PROS1): c.601+12A> G single nucleotide variant Uncertain significance rs753550053 GRCh37 Chromosome 3, 93624616: 93624616
57 PROS1 NM_000313.3(PROS1): c.-116C> T single nucleotide variant Uncertain significance rs886058929 GRCh38 Chromosome 3, 93973865: 93973865
58 PROS1 NM_000313.3(PROS1): c.-116C> T single nucleotide variant Uncertain significance rs886058929 GRCh37 Chromosome 3, 93692709: 93692709
59 PROS1 NM_000313.3(PROS1): c.-135C> T single nucleotide variant Uncertain significance rs750502941 GRCh38 Chromosome 3, 93973884: 93973884
60 PROS1 NM_000313.3(PROS1): c.-135C> T single nucleotide variant Uncertain significance rs750502941 GRCh37 Chromosome 3, 93692728: 93692728
61 PROS1 NM_000313.3(PROS1): c.*1167_*1170delTTTG deletion Uncertain significance rs886058921 GRCh38 Chromosome 3, 93873075: 93873078
62 PROS1 NM_000313.3(PROS1): c.*1167_*1170delTTTG deletion Uncertain significance rs886058921 GRCh37 Chromosome 3, 93591919: 93591922
63 PROS1 NM_000313.3(PROS1): c.*1139C> A single nucleotide variant Uncertain significance rs886058922 GRCh38 Chromosome 3, 93873106: 93873106
64 PROS1 NM_000313.3(PROS1): c.*1139C> A single nucleotide variant Uncertain significance rs886058922 GRCh37 Chromosome 3, 93591950: 93591950
65 PROS1 NM_000313.3(PROS1): c.*783C> T single nucleotide variant Uncertain significance rs137965257 GRCh38 Chromosome 3, 93873462: 93873462
66 PROS1 NM_000313.3(PROS1): c.*783C> T single nucleotide variant Uncertain significance rs137965257 GRCh37 Chromosome 3, 93592306: 93592306
67 PROS1 NM_000313.3(PROS1): c.*693G> A single nucleotide variant Uncertain significance rs189450409 GRCh38 Chromosome 3, 93873552: 93873552
68 PROS1 NM_000313.3(PROS1): c.*693G> A single nucleotide variant Uncertain significance rs189450409 GRCh37 Chromosome 3, 93592396: 93592396
69 PROS1 NM_000313.3(PROS1): c.*686G> A single nucleotide variant Uncertain significance rs550909963 GRCh38 Chromosome 3, 93873559: 93873559
70 PROS1 NM_000313.3(PROS1): c.*686G> A single nucleotide variant Uncertain significance rs550909963 GRCh37 Chromosome 3, 93592403: 93592403
71 PROS1 NM_000313.3(PROS1): c.*422G> T single nucleotide variant Uncertain significance rs770100925 GRCh38 Chromosome 3, 93873823: 93873823
72 PROS1 NM_000313.3(PROS1): c.*422G> T single nucleotide variant Uncertain significance rs770100925 GRCh37 Chromosome 3, 93592667: 93592667
73 PROS1 NM_000313.3(PROS1): c.*301A> G single nucleotide variant Uncertain significance rs569117154 GRCh38 Chromosome 3, 93873944: 93873944
74 PROS1 NM_000313.3(PROS1): c.*301A> G single nucleotide variant Uncertain significance rs569117154 GRCh37 Chromosome 3, 93592788: 93592788
75 PROS1 NM_000313.3(PROS1): c.1494T> C (p.Asn498=) single nucleotide variant Uncertain significance rs76877671 GRCh38 Chromosome 3, 93879313: 93879313
76 PROS1 NM_000313.3(PROS1): c.1494T> C (p.Asn498=) single nucleotide variant Uncertain significance rs76877671 GRCh37 Chromosome 3, 93598157: 93598157
77 PROS1 NM_000313.3(PROS1): c.1021G> A (p.Ala341Thr) single nucleotide variant Uncertain significance rs189883848 GRCh38 Chromosome 3, 93893067: 93893067
78 PROS1 NM_000313.3(PROS1): c.1021G> A (p.Ala341Thr) single nucleotide variant Uncertain significance rs189883848 GRCh37 Chromosome 3, 93611911: 93611911
79 PROS1 NM_000313.3(PROS1): c.710A> C (p.Lys237Thr) single nucleotide variant Uncertain significance rs558211174 GRCh38 Chromosome 3, 93900821: 93900821
80 PROS1 NM_000313.3(PROS1): c.710A> C (p.Lys237Thr) single nucleotide variant Uncertain significance rs558211174 GRCh37 Chromosome 3, 93619665: 93619665
81 PROS1 NM_000313.3(PROS1): c.119G> T (p.Arg40Leu) single nucleotide variant Benign/Likely benign rs7614835 GRCh38 Chromosome 3, 93927365: 93927365
82 PROS1 NM_000313.3(PROS1): c.119G> T (p.Arg40Leu) single nucleotide variant Benign/Likely benign rs7614835 GRCh37 Chromosome 3, 93646209: 93646209
83 PROS1 NM_000313.3(PROS1): c.-43G> A single nucleotide variant Uncertain significance rs370938580 GRCh38 Chromosome 3, 93973792: 93973792
84 PROS1 NM_000313.3(PROS1): c.-43G> A single nucleotide variant Uncertain significance rs370938580 GRCh37 Chromosome 3, 93692636: 93692636
85 PROS1 NM_000313.3(PROS1): c.*86T> C single nucleotide variant Uncertain significance rs886058925 GRCh37 Chromosome 3, 93593003: 93593003
86 PROS1 NM_000313.3(PROS1): c.*714T> C single nucleotide variant Uncertain significance rs886058923 GRCh38 Chromosome 3, 93873531: 93873531
87 PROS1 NM_000313.3(PROS1): c.*714T> C single nucleotide variant Uncertain significance rs886058923 GRCh37 Chromosome 3, 93592375: 93592375
88 PROS1 NM_000313.3(PROS1): c.*520A> C single nucleotide variant Likely benign rs9681204 GRCh38 Chromosome 3, 93873725: 93873725
89 PROS1 NM_000313.3(PROS1): c.*520A> C single nucleotide variant Likely benign rs9681204 GRCh37 Chromosome 3, 93592569: 93592569
90 PROS1 NM_000313.3(PROS1): c.*370G> A single nucleotide variant Uncertain significance rs144135580 GRCh38 Chromosome 3, 93873875: 93873875
91 PROS1 NM_000313.3(PROS1): c.*370G> A single nucleotide variant Uncertain significance rs144135580 GRCh37 Chromosome 3, 93592719: 93592719
92 PROS1 NM_000313.3(PROS1): c.*221delA deletion Uncertain significance rs776969264 GRCh38 Chromosome 3, 93874024: 93874024
93 PROS1 NM_000313.3(PROS1): c.*221delA deletion Uncertain significance rs776969264 GRCh37 Chromosome 3, 93592868: 93592868
94 PROS1 NM_000313.3(PROS1): c.*86T> C single nucleotide variant Uncertain significance rs886058925 GRCh38 Chromosome 3, 93874159: 93874159
95 PROS1 NM_000313.3(PROS1): c.805G> A (p.Gly269Arg) single nucleotide variant Uncertain significance rs886058927 GRCh38 Chromosome 3, 93898492: 93898492
96 PROS1 NM_000313.3(PROS1): c.805G> A (p.Gly269Arg) single nucleotide variant Uncertain significance rs886058927 GRCh37 Chromosome 3, 93617336: 93617336
97 PROS1 NM_000313.3(PROS1): c.234G> A (p.Thr78=) single nucleotide variant Uncertain significance rs145399944 GRCh38 Chromosome 3, 93927250: 93927250
98 PROS1 NM_000313.3(PROS1): c.234G> A (p.Thr78=) single nucleotide variant Uncertain significance rs145399944 GRCh37 Chromosome 3, 93646094: 93646094
99 PROS1 NM_000313.3(PROS1): c.-60G> C single nucleotide variant Uncertain significance rs368555701 GRCh38 Chromosome 3, 93973809: 93973809
100 PROS1 NM_000313.3(PROS1): c.-60G> C single nucleotide variant Uncertain significance rs368555701 GRCh37 Chromosome 3, 93692653: 93692653
101 PROS1 NM_000313.3(PROS1): c.-62T> G single nucleotide variant Uncertain significance rs556711298 GRCh38 Chromosome 3, 93973811: 93973811
102 PROS1 NM_000313.3(PROS1): c.-62T> G single nucleotide variant Uncertain significance rs556711298 GRCh37 Chromosome 3, 93692655: 93692655
103 PROS1 NM_000313.3(PROS1): c.*119T> C single nucleotide variant Uncertain significance rs886058924 GRCh38 Chromosome 3, 93874126: 93874126
104 PROS1 NM_000313.3(PROS1): c.*119T> C single nucleotide variant Uncertain significance rs886058924 GRCh37 Chromosome 3, 93592970: 93592970
105 PROS1 NM_000313.3(PROS1): c.2003C> T (p.Ser668Leu) single nucleotide variant Uncertain significance rs886058926 GRCh38 Chromosome 3, 93874273: 93874273
106 PROS1 NM_000313.3(PROS1): c.2003C> T (p.Ser668Leu) single nucleotide variant Uncertain significance rs886058926 GRCh37 Chromosome 3, 93593117: 93593117
107 PROS1 NM_000313.3(PROS1): c.1323+8T> G single nucleotide variant Uncertain significance rs778473220 GRCh38 Chromosome 3, 93886328: 93886328
108 PROS1 NM_000313.3(PROS1): c.1323+8T> G single nucleotide variant Uncertain significance rs778473220 GRCh37 Chromosome 3, 93605172: 93605172
109 PROS1 NM_000313.3(PROS1): c.1032C> T (p.Ile344=) single nucleotide variant Benign/Likely benign rs78449232 GRCh38 Chromosome 3, 93893056: 93893056
110 PROS1 NM_000313.3(PROS1): c.1032C> T (p.Ile344=) single nucleotide variant Benign/Likely benign rs78449232 GRCh37 Chromosome 3, 93611900: 93611900
111 PROS1 NM_000313.3(PROS1): c.585T> C (p.Asn195=) single nucleotide variant Uncertain significance rs372109285 GRCh38 Chromosome 3, 93905800: 93905800
112 PROS1 NM_000313.3(PROS1): c.585T> C (p.Asn195=) single nucleotide variant Uncertain significance rs372109285 GRCh37 Chromosome 3, 93624644: 93624644
113 PROS1 NM_000313.3(PROS1): c.503A> G (p.Asn168Ser) single nucleotide variant Uncertain significance rs144430063 GRCh38 Chromosome 3, 93905882: 93905882
114 PROS1 NM_000313.3(PROS1): c.503A> G (p.Asn168Ser) single nucleotide variant Uncertain significance rs144430063 GRCh37 Chromosome 3, 93624726: 93624726
115 PROS1 NM_000313.3(PROS1): c.111T> C (p.Val37=) single nucleotide variant Uncertain significance rs886058928 GRCh38 Chromosome 3, 93927373: 93927373
116 PROS1 NM_000313.3(PROS1): c.111T> C (p.Val37=) single nucleotide variant Uncertain significance rs886058928 GRCh37 Chromosome 3, 93646217: 93646217
117 PROS1 NM_000313.3(PROS1): c.-261C> T single nucleotide variant Uncertain significance rs886058930 GRCh38 Chromosome 3, 93974010: 93974010
118 PROS1 NM_000313.3(PROS1): c.-261C> T single nucleotide variant Uncertain significance rs886058930 GRCh37 Chromosome 3, 93692854: 93692854

Expression for Protein S Deficiency

Search GEO for disease gene expression data for Protein S Deficiency.

Pathways for Protein S Deficiency

GO Terms for Protein S Deficiency

Cellular components related to Protein S Deficiency according to GeneCards Suite gene sharing:

(showing 6, show less)
# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 APOH C4BPA F2 F3 F5 PROS1
2 endoplasmic reticulum lumen GO:0005788 9.5 F2 F5 SERPINC1
3 collagen-containing extracellular matrix GO:0062023 9.43 APOH F3 SERPINC1
4 platelet alpha granule lumen GO:0031093 9.37 F5 PROS1
5 blood microparticle GO:0072562 9.26 C4BPA F2 PROS1 SERPINC1
6 extracellular space GO:0005615 9.17 APOH C4BPA F2 F3 F5 PROS1

Biological processes related to Protein S Deficiency according to GeneCards Suite gene sharing:

(showing 13, show less)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.69 F2 F5 SERPINC1
2 ER to Golgi vesicle-mediated transport GO:0006888 9.67 F2 F5 PROS1
3 platelet degranulation GO:0002576 9.54 APOH F5 PROS1
4 blood circulation GO:0008015 9.52 F5 MTHFR
5 regulation of complement activation GO:0030449 9.5 C4BPA F2 PROS1
6 fibrinolysis GO:0042730 9.48 F2 PROS1
7 blood coagulation, intrinsic pathway GO:0007597 9.46 APOH F2
8 negative regulation of blood coagulation GO:0030195 9.43 APOH PROS1
9 positive regulation of blood coagulation GO:0030194 9.4 APOH F2
10 blood coagulation GO:0007596 9.35 F2 F3 F5 PROS1 SERPINC1
11 regulation of blood coagulation GO:0030193 9.33 APOH F2 SERPINC1
12 negative regulation of fibrinolysis GO:0051918 9.26 APOH F2
13 hemostasis GO:0007599 9.02 F2 F3 F5 PROS1 SERPINC1

Molecular functions related to Protein S Deficiency according to GeneCards Suite gene sharing:

(showing 1, show less)
# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 8.8 APOH F2 SERPINC1

Sources for Protein S Deficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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