MCID: PRT045
MIFTS: 31

Prothrombin-Related Thrombophilia

Categories: Blood diseases, Cardiovascular diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Prothrombin-Related Thrombophilia

MalaCards integrated aliases for Prothrombin-Related Thrombophilia:

Name: Prothrombin-Related Thrombophilia 24 53
Prothrombin G20210a Thrombophilia 24 53 25
Prothrombin Thrombophilia 24 53 25
Hyperprothrombinemia 53 25 72
Prothrombin 20210g>a Thrombophilia 24 53
Factor Ii-Related Thrombophilia 24 53
F2-Related Thrombophilia 24 53
Thrombophilia Due to Factor 2 Defect 53

Classifications:



External Ids:

UMLS 72 C1867596

Summaries for Prothrombin-Related Thrombophilia

Genetics Home Reference : 25 Prothrombin thrombophilia is an inherited disorder of blood clotting. Thrombophilia is an increased tendency to form abnormal blood clots in blood vessels. People who have prothrombin thrombophilia are at somewhat higher than average risk for a type of clot called a deep venous thrombosis, which typically occurs in the deep veins of the legs. Affected people also have an increased risk of developing a pulmonary embolism, which is a clot that travels through the bloodstream and lodges in the lungs. Most people with prothrombin thrombophilia never develop abnormal blood clots, however. Some research suggests that prothrombin thrombophilia is associated with a somewhat increased risk of pregnancy loss (miscarriage) and may also increase the risk of other complications during pregnancy. These complications may include pregnancy-induced high blood pressure (preeclampsia), slow fetal growth, and early separation of the placenta from the uterine wall (placental abruption). It is important to note, however, that most women with prothrombin thrombophilia have normal pregnancies.

MalaCards based summary : Prothrombin-Related Thrombophilia, also known as prothrombin g20210a thrombophilia, is related to thrombophilia and thrombophilia due to activated protein c resistance. An important gene associated with Prothrombin-Related Thrombophilia is F13A1 (Coagulation Factor XIII A Chain), and among its related pathways/superpathways are Selenium Micronutrient Network and Formation of Fibrin Clot (Clotting Cascade). The drugs Thrombin and Hemostatics have been mentioned in the context of this disorder. Affiliated tissues include lung, placenta and testes.

NIH Rare Diseases : 53 Prothrombin thrombophilia is a genetic disorder of blood clotting. Individuals who have a thrombophilia have an increased risk to form abnormal blood clots in blood vessels. Those with prothrombin thrombophilia are at somewhat higher than average risk for a type of clot that typically occurs in the deep veins of the legs (deep venous thrombosis). There is additionally an increased risk of developing a clot that lodges in the lungs (pulmonary embolism); however, most people with prothrombin thrombophilia never develop abnormal blood clots. This condition is caused by a particular mutation (written G20210A or 20210G>A) in the F2 gene. People can inherit one or two copies of the gene mutation from their parents. The treatment for this condition is dependent on whether a blood clot has occurred and if there are additional risk factors. In individuals with a history of one or more blood clots, blood thinning medications may be used.

GeneReviews: NBK1148

Related Diseases for Prothrombin-Related Thrombophilia

Diseases related to Prothrombin-Related Thrombophilia via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 55, show less)
# Related Disease Score Top Affiliating Genes
1 thrombophilia 30.3 MTHFR F2
2 thrombophilia due to activated protein c resistance 30.2 MTHFR F2
3 placental abruption 30.1 MTHFR F2
4 thrombosis 29.6 MTHFR F2 F13A1
5 pre-eclampsia 29.6 MTHFR F2
6 thrombophilia due to thrombin defect 28.4 MTHFR HABP2 F2 F13A1
7 portal hypertension 10.2
8 hepatitis 10.2
9 liver cirrhosis 10.2
10 spinal cord infarction 10.1 MTHFR F2
11 sudden sensorineural hearing loss 10.1 MTHFR F2
12 mesenteric vascular occlusion 10.1 MTHFR F2
13 ischemic neuropathy 10.1 MTHFR F2
14 cryptogenic cirrhosis 10.1 MTHFR F2
15 porencephaly 10.1 MTHFR F2
16 marantic endocarditis 10.1 MTHFR F2
17 livedoid vasculitis 10.1 MTHFR F2
18 thrombophlebitis 10.1 MTHFR F2
19 retinal vascular occlusion 10.1 MTHFR F2
20 hepatic infarction 10.1 MTHFR F2
21 antithrombin iii deficiency 10.0 MTHFR F2
22 blood protein disease 10.0 MTHFR F2
23 central retinal vein occlusion 10.0 MTHFR F2
24 retinal vein occlusion 10.0 MTHFR F2
25 buerger disease 10.0 MTHFR F2
26 retinal artery occlusion 10.0 MTHFR F2
27 branch retinal artery occlusion 10.0 MTHFR F2
28 portal vein thrombosis 10.0 MTHFR F2
29 dysfibrinogenemia 10.0 F2 F13A1
30 pulmonary artery disease 10.0 MTHFR F2
31 hepatic vascular disease 10.0 MTHFR F2
32 arteritic anterior ischemic optic neuropathy 10.0 MTHFR F2
33 protein s deficiency 10.0 MTHFR F2
34 thrombasthenia 10.0 MTHFR F2
35 vein disease 10.0 MTHFR F2
36 protein c deficiency 10.0 MTHFR F2
37 intracranial hypertension 10.0 MTHFR F2
38 blood coagulation disease 10.0 MTHFR F2
39 nonarteritic anterior ischemic optic neuropathy 9.9 MTHFR F2
40 osteonecrosis 9.9 MTHFR F2
41 homocysteinemia 9.9 MTHFR F2
42 budd-chiari syndrome 9.9 MTHFR F2
43 varicose veins 9.9 MTHFR F2
44 sickle cell anemia 9.9 MTHFR F2
45 antiphospholipid syndrome 9.9 MTHFR F2
46 pulmonary embolism 9.8 MTHFR F2
47 cerebral palsy 9.8 MTHFR F2
48 eclampsia 9.8 MTHFR F2
49 carotid stenosis 9.8 MTHFR HABP2
50 hemorrhagic disease 9.7 F2 F13A1
51 hellp syndrome 9.7 MTHFR F2
52 patent foramen ovale 9.6 MTHFR F2 F13A1
53 cerebrovascular disease 9.6 MTHFR F2
54 stroke, ischemic 9.4 MTHFR F2
55 myocardial infarction 9.3 MTHFR F2 F13A1

Graphical network of the top 20 diseases related to Prothrombin-Related Thrombophilia:



Diseases related to Prothrombin-Related Thrombophilia

Symptoms & Phenotypes for Prothrombin-Related Thrombophilia

Drugs & Therapeutics for Prothrombin-Related Thrombophilia

Drugs for Prothrombin-Related Thrombophilia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 3, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Thrombin Approved, Investigational
2 Hemostatics
3 Coagulants

Interventional clinical trials:

(showing 1, show less)
# Name Status NCT ID Phase Drugs
1 The Role of Prothrombin Gene Polymorphism as a Risk Factor for Recurrent Pregnancy Loss Unknown status NCT03209063

Search NIH Clinical Center for Prothrombin-Related Thrombophilia

Genetic Tests for Prothrombin-Related Thrombophilia

Anatomical Context for Prothrombin-Related Thrombophilia

MalaCards organs/tissues related to Prothrombin-Related Thrombophilia:

41
Lung, Placenta, Testes, Breast, Liver, Heart

Publications for Prothrombin-Related Thrombophilia

Articles related to Prothrombin-Related Thrombophilia:

(showing 271, show less)
# Title Authors PMID Year
1
Antepartum dalteparin versus no antepartum dalteparin for the prevention of pregnancy complications in pregnant women with thrombophilia (TIPPS): a multinational open-label randomised trial. 4
25066248 2014
2
Advantages and limitations of the new anticoagulants. 4
24112453 2014
3
Comparative incidence of pregnancy outcomes in treated obstetric antiphospholipid syndrome: the NOH-APS observational study. 4
24200687 2014
4
Cerebral venous thrombosis and thrombophilia: a systematic review and meta-analysis. 4
24129682 2013
5
Testing for inherited thrombophilia and consequences for antithrombotic prophylaxis in patients with venous thromboembolism and their relatives. A review of the Guidelines from Scientific Societies and Working Groups. 4
23846575 2013
6
ACOG Practice Bulletin No. 138: Inherited thrombophilias in pregnancy. 4
23963422 2013
7
The methylenetetrahydrofolate reductase polymorphism (MTHFR c.677C>T) and elevated plasma homocysteine levels in a U.S. pediatric population with incident thromboembolism. 4
23866722 2013
8
Thrombosis in women: what are the knowledge gaps in 2013? 4
23809122 2013
9
ACOG committee opinion no. 556: Postmenopausal estrogen therapy: route of administration and risk of venous thromboembolism. 4
23635705 2013
10
NICE guideline: management of venous thromboembolic diseases and role of thrombophilia testing. 4
23234857 2013
11
Use of medications to reduce risk for primary breast cancer: a systematic review for the U.S. Preventive Services Task Force. 4
23588749 2013
12
The ASH Choosing Wisely®campaign: five hematologic tests and treatments to question. 4
24319155 2013
13
International clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer. 4
23217107 2013
14
The risk of venous thrombosis in women over 50 years old using oral contraception or postmenopausal hormone therapy. 4
23136837 2013
15
Thrombophilia testing for prevention of recurrent venous thromboembolism. 4
23235639 2012
16
Guidelines on the investigation and management of venous thrombosis at unusual sites. 4
22881455 2012
17
Long-term outcomes of patients with cerebral vein thrombosis: a multicenter study. 4
22578023 2012
18
Elevated factor VIII levels and risk of venous thrombosis. 4
22530883 2012
19
Thrombosis from a prothrombin mutation conveying antithrombin resistance. 4
22716977 2012
20
Heparin in pregnant women with previous placenta-mediated pregnancy complications: a prospective, randomized, multicenter, controlled clinical trial. 4
22289887 2012
21
Low-molecular-weight heparin added to aspirin in the prevention of recurrent early-onset pre-eclampsia in women with inheritable thrombophilia: the FRUIT-RCT. 4
22118560 2012
22
Addition of enoxaparin to aspirin for the secondary prevention of placental vascular complications in women with severe pre-eclampsia. The pilot randomised controlled NOH-PE trial. 4
21946915 2011
23
Progestogens and venous thromboembolism among postmenopausal women using hormone therapy. 4
22024394 2011
24
Thrombophilia in childhood: to test or not to test. 4
22187402 2011
25
Does the route of administration for estrogen hormone therapy impact the risk of venous thromboembolism? Estradiol transdermal system versus oral estrogen-only hormone therapy. 4
21775912 2011
26
In families with inherited thrombophilia the risk of venous thromboembolism is dependent on the clinical phenotype of the proband. 4
21833444 2011
27
Pediatric venous and arterial noncerebral thromboembolism in Denmark: a nationwide population-based study. 4
21596390 2011
28
Prothrombotic gene polymorphisms: possible contributors to hepatic artery thrombosis after orthotopic liver transplantation. 4
21836539 2011
29
Thrombotic risk during oral contraceptive use and pregnancy in women with factor V Leiden or prothrombin mutation: a rational approach to contraception. 4
21659542 2011
30
Guideline on the investigation, management and prevention of venous thrombosis in children. 4
21595646 2011
31
Factor XIII and venous thromboembolism. 4
21455864 2011
32
Thromboprophylaxis for recurrent miscarriage in women with or without thrombophilia. HABENOX: a randomised multicentre trial. 4
21103659 2011
33
Genetics of venous thrombosis: insights from a new genome wide association study. 4
21980494 2011
34
Factor V Leiden thrombophilia. 4
21116184 2011
35
Recommendations from the EGAPP Working Group: routine testing for Factor V Leiden (R506Q) and prothrombin (20210G>A) mutations in adults with a history of idiopathic venous thromboembolism and their adult family members. 4
21150787 2011
36
Risk assessment for recurrent venous thrombosis. 4
21131039 2010
37
Risk of venous thrombosis in pregnancy among carriers of the factor V Leiden and the prothrombin gene G20210A polymorphisms. 4
20735725 2010
38
Venous thrombosis risk associated with plasma hypofibrinolysis is explained by elevated plasma levels of TAFI and PAI-1. 4
20385790 2010
39
The association of factor V leiden and prothrombin gene mutation and placenta-mediated pregnancy complications: a systematic review and meta-analysis of prospective cohort studies. 4
20563311 2010
40
Extended case-control study results on thromboembolic outcomes among transdermal contraceptive users. 4
20399947 2010
41
Hormone replacement therapy and the risk of venous thromboembolism: a population-based study. 4
20230416 2010
42
Prothrombin G20210A carriers the genetic mutation and a history of venous thrombosis contributes to thrombin generation independently of factor II plasma levels. 4
20096005 2010
43
SPIN (Scottish Pregnancy Intervention) study: a multicenter, randomized controlled trial of low-molecular-weight heparin and low-dose aspirin in women with recurrent miscarriage. 4
20237316 2010
44
Aspirin plus heparin or aspirin alone in women with recurrent miscarriage. 4
20335572 2010
45
Risk of recurrent venous thrombosis in homozygous carriers and double heterozygous carriers of factor V Leiden and prothrombin G20210A. 4
20368522 2010
46
Impact of thrombophilia on risk of arterial ischemic stroke or cerebral sinovenous thrombosis in neonates and children: a systematic review and meta-analysis of observational studies. 4
20385928 2010
47
Clinical guidelines for testing for heritable thrombophilia. 4
20128794 2010
48
Postmenopausal hormone therapy and risk of idiopathic venous thromboembolism: results from the E3N cohort study. 4
19834106 2010
49
Clinical course of high-risk patients diagnosed with antiphospholipid syndrome. 4
19874470 2010
50
A prospective case-control study analyzes 12 thrombophilic gene mutations in Turkish couples with recurrent pregnancy loss. 4
19906129 2010
51
Inherited thrombophilia polymorphisms and pregnancy outcomes in nulliparous women. 4
20027027 2010
52
Prothrombin gene G20210A mutation and obstetric complications. 4
20027028 2010
53
Risk factors for clinical manifestations in carriers of Factor V Leiden and prothrombin gene mutations. 4
19474699 2010
54
Thrombophilic factors do not predict outcomes in renal transplant recipients under prophylactic acetylsalicylic acid. 4
19845577 2010
55
Duration of anticoagulation: applying the guidelines and beyond. 4
21239796 2010
56
Factors that predict risk of thrombosis in relatives of patients with unprovoked venous thromboembolism. 4
19592474 2009
57
Altered fibrin clot structure/function in patients with idiopathic venous thromboembolism and in their relatives. 4
19690336 2009
58
Testing children for inherited thrombophilia: more questions than answers. 4
19656153 2009
59
Coagulation factors IX through XIII and the risk of future venous thrombosis: the Longitudinal Investigation of Thromboembolism Etiology. 4
19617576 2009
60
Prothrombin 20209C>T: 16 new cases, association with the 19911A>G polymorphism, and literature review. 4
19522744 2009
61
The genetics of venous thromboembolism. A meta-analysis involving approximately 120,000 cases and 180,000 controls. 4
19652888 2009
62
Genetics of venous thrombosis. 4
19630821 2009
63
Duration of anticoagulation after initial idiopathic venous thrombosis--the swinging pendulum: risk assessment to predict recurrence. 4
19630819 2009
64
A risk score for the management of pregnant women with increased risk of venous thromboembolism: a multicentre prospective study. 4
19388925 2009
65
Genetic thrombophilias and intrauterine growth restriction: a meta-analysis. 4
19461414 2009
66
Genetic polymorphisms in venous thrombosis and pulmonary embolism after total hip arthroplasty: a pilot study. 4
18800213 2009
67
Predictive value of factor V Leiden and prothrombin G20210A in adults with venous thromboembolism and in family members of those with a mutation: a systematic review. 4
19531787 2009
68
Selective testing for thrombophilia in patients with first venous thrombosis: results from a retrospective family cohort study on absolute thrombotic risk for currently known thrombophilic defects in 2479 relatives. 4
19139080 2009
69
Do common prothrombotic mutations influence the risk of cerebral ischaemia in patients with patent foramen ovale? Systematic review and meta-analysis. 4
19404532 2009
70
Association of inherited thrombophilia with embryonic and postembryonic recurrent pregnancy loss. 4
19786941 2009
71
Thromboprophylaxis and pregnancy outcomes in asymptomatic women with inherited thrombophilias. 4
19114274 2009
72
The value of family history as a risk indicator for venous thrombosis. 4
19307525 2009
73
Inherited thrombophilia and preeclampsia: is the evidence beginning to congeal? 4
19185098 2009
74
Low molecular weight heparin and aspirin for recurrent pregnancy loss: results from the randomized, controlled HepASA Trial. 4
19208560 2009
75
Inherited thrombophilia and preeclampsia within a multicenter cohort: the Montreal Preeclampsia Study. 4
19070828 2009
76
Inherited thrombophilias and unexplained pregnancy loss: an incident case-control study. 4
19036071 2009
77
Ocular vascular thrombotic events: a diagnostic window to familial thrombophilia (compound factor V Leiden and prothrombin gene heterozygosity) and thrombosis. 4
18796459 2009
78
Influence of the factor II G20210A variant or the factor V G1691A mutation on symptomatic recurrent venous thromboembolism in children: an international multicenter cohort study. 4
18983482 2009
79
Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994. 4
18936436 2009
80
Maternal thrombophilia and the risk of recurrence of preeclampsia. 4
18845284 2009
81
Hereditary thrombophilic factors in stroke due to cerebral infarct. 4
19263510 2009
82
Influence of thrombophilia on risk of recurrent venous thromboembolism while on warfarin: results from a randomized trial. 4
18791166 2008
83
Factor V Leiden is associated with pre-eclampsia but not with fetal growth restriction: a genetic association study and meta-analysis. 4
18752569 2008
84
Does thrombophilia testing help in the clinical management of patients? 4
18710381 2008
85
Paternal thrombophilic gene mutations are not associated with recurrent miscarriage. 4
18754836 2008
86
Impact of inherited thrombophilia on venous thromboembolism in children: a systematic review and meta-analysis of observational studies. 4
18779442 2008
87
Hereditary and acquired thrombophilia in patients with upper extremity deep-vein thrombosis. Results from the MAISTHRO registry. 4
18766260 2008
88
Comparison between idiopathic deep vein thrombosis of the upper and lower extremity regarding risk factors and recurrence. 4
18445117 2008
89
Recurrent venous thromboembolism after pregnancy-associated versus unprovoked thromboembolism. 4
18690344 2008
90
Inherited thrombophilia and pregnancy complications revisited. 4
18669729 2008
91
Hormone replacement therapy and risk of venous thromboembolism in postmenopausal women: systematic review and meta-analysis. 4
18495631 2008
92
Inherited thrombophilic abnormalities and risk of portal vein thrombosis. a meta-analysis. 4
18392325 2008
93
Pregnancy, the postpartum period and prothrombotic defects: risk of venous thrombosis in the MEGA study. 4
18248600 2008
94
The risk of first venous thromboembolism during pregnancy and puerperium in double heterozygotes for factor V Leiden and prothrombin G20210A. 4
18182035 2008
95
Gene variants associated with deep vein thrombosis. 4
18349091 2008
96
Inheritance and perinatal consequences of inherited thrombophilia in Greece. 4
17963764 2008
97
Are patients with thrombophilia and previous venous thromboembolism at higher risk to arterial thrombosis? 4
17804043 2008
98
Minor injuries as a risk factor for venous thrombosis. 4
18195191 2008
99
Association between inherited thrombophilic abnormalities and central venous catheter thrombosis in patients with cancer: a meta-analysis. 4
17988232 2008
100
Thrombophilias and adverse pregnancy outcome - A confounded problem! 4
18217138 2008
101
Family history as a risk factor for venous thromboembolism. 4
18281082 2008
102
Thrombophilia in children: who to test, how, when, and why? 4
19074088 2008
103
Risk stratification and heparin prophylaxis to prevent venous thromboembolism in pregnant women. 4
18064320 2007
104
Risk of venous thrombosis: obesity and its joint effect with oral contraceptive use and prothrombotic mutations. 4
17897305 2007
105
The risk of recurrent venous thromboembolism among heterozygous carriers of factor V Leiden or prothrombin G20210A mutation. A systematic review of prospective studies. 4
17650440 2007
106
Further results on the risk of nonfatal venous thromboembolism in users of the contraceptive transdermal patch compared to users of oral contraceptives containing norgestimate and 35 microg of ethinyl estradiol. 4
17586129 2007
107
Outcome of the subsequent pregnancy after a first loss in women with the factor V Leiden or prothrombin 20210A mutations. 4
17439630 2007
108
No association between the common MTHFR 677C->T polymorphism and venous thrombosis: results from the MEGA study. 4
17353498 2007
109
Hormone therapy and venous thromboembolism among postmenopausal women: impact of the route of estrogen administration and progestogens: the ESTHER study. 4
17309934 2007
110
The risk of recurrent venous thromboembolism after discontinuing anticoagulation in patients with acute proximal deep vein thrombosis or pulmonary embolism. A prospective cohort study in 1,626 patients. 4
17296569 2007
111
Association of genetic variations with nonfatal venous thrombosis in postmenopausal women. 4
17284699 2007
112
Prevalence of Factor V 1691 G-A (Leiden) and prothrombin G20210A polymorphisms and the risk of venous thrombosis among cancer patients. 4
17106650 2007
113
Venous thromboembolism, myocardial infarction, and stroke among transdermal contraceptive system users. 4
17267834 2007
114
Obstetric complications in patients with hereditary thrombophilia identified using the LCx microparticle enzyme immunoassay: a controlled study of 5,000 patients. 4
17145624 2007
115
Homocysteine lowering by B vitamins and the secondary prevention of deep vein thrombosis and pulmonary embolism: A randomized, placebo-controlled, double-blind trial. 4
16960155 2007
116
Congenital prothrombotic disorders in children with peripheral venous and arterial thromboses. 4
17159337 2007
117
Thrombophilia and risk of venous thrombosis in patients with cancer. 4
18023713 2007
118
Conjugated equine estrogen, esterified estrogen, prothrombotic variants, and the risk of venous thrombosis in postmenopausal women. 4
16973976 2006
119
Prothrombin A19911G polymorphism and the risk of venous thromboembolism. 4
16981886 2006
120
The association of prothrombin A19911G polymorphism with plasma prothrombin activity and venous thrombosis: results of the MEGA study, a large population-based case-control study. 4
17059428 2006
121
The risk of recurrent venous thromboembolism in pregnancy and puerperium without antithrombotic prophylaxis. 4
16984390 2006
122
A prospective cohort study on the absolute incidence of venous thromboembolism and arterial cardiovascular disease in asymptomatic carriers of the prothrombin 20210A mutation. 4
16778142 2006
123
Factor XIII Val34Leu variant is protective against venous thromboembolism: a HuGE review and meta-analysis. 4
16740590 2006
124
Effect of Factor V Leiden and prothrombin G20210-->A mutations on thromboembolic risk in the national surgical adjuvant breast and bowel project breast cancer prevention trial. 4
16818854 2006
125
Effects of raloxifene on cardiovascular events and breast cancer in postmenopausal women. 4
16837676 2006
126
Prothrombin 20210G>A is an ancestral prothrombotic mutation that occurred in whites approximately 24,000 years ago. 4
16493002 2006
127
The prothrombin 20209 C-->T mutation in Jewish-Moroccan Caucasians: molecular analysis of gain-of-function of 3' end processing. 4
16689762 2006
128
Venous thromboembolism during pregnancy and the postpartum period: incidence, risk factors, and mortality. 4
16647915 2006
129
Risk of recurrent venous thromboembolism in patients with common thrombophilia: a systematic review. 4
16606808 2006
130
Common genetic variation in the prothrombin gene, hormone therapy, and incident nonfatal myocardial infarction in postmenopausal women. 4
16467413 2006
131
Thrombophilic abnormalities, oral contraceptives, and risk of cerebral vein thrombosis: a meta-analysis. 4
16397131 2006
132
Does use of hormonal contraceptives among women with thrombogenic mutations increase their risk of venous thromboembolism? A systematic review. 4
16413847 2006
133
Seven haemostatic gene polymorphisms in coronary disease: meta-analysis of 66,155 cases and 91,307 controls. 4
16503463 2006
134
Risk of recurrent venous thrombosis in patients with G20210A mutation in the prothrombin gene or factor V Leiden mutation. 4
16607075 2006
135
The prevalence of the prothrombin gene variant C20209T in African-Americans and Caucasians and lack of association with venous thromboembolism. 4
16469364 2006
136
Thrombophilia in children with venous thromboembolic disease. 4
15993476 2006
137
Thrombophilia in pregnancy: a systematic review. 4
16398652 2006
138
Prothrombotic abnormalities in childhood ischaemic stroke. 4
16039697 2006
139
Thrombophilia is significantly associated with severe preeclampsia: results of a large-scale, case-controlled study. 4
16246971 2005
140
Prothrombotic mutations, hormone therapy, and venous thromboembolism among postmenopausal women: impact of the route of estrogen administration. 4
16301339 2005
141
Old and new risk factors for upper extremity deep venous thrombosis. 4
16241945 2005
142
Characterization of a novel prothrombin variant, Prothrombin C20209T, as a modifier of thrombotic risk among African-Americans. 4
16194213 2005
143
Technical standards and guidelines: venous thromboembolism (Factor V Leiden and prothrombin 20210G >A testing): a disease-specific supplement to the standards and guidelines for clinical genetics laboratories. 4
16024978 2005
144
Oral contraceptives, hormone replacement therapy, thrombophilias and risk of venous thromboembolism: a systematic review. The Thrombosis: Risk and Economic Assessment of Thrombophilia Screening (TREATS) Study. 4
16113779 2005
145
Prothrombotic conditions, oral contraceptives, and the risk of ischemic stroke. 4
15946211 2005
146
Retinal vein occlusion: a form of venous thrombosis or a complication of atherosclerosis? A meta-analysis of thrombophilic factors. 4
15968383 2005
147
Thrombophilia, clinical factors, and recurrent venous thrombotic events. 4
15900005 2005
148
Risk of pregnancy-associated recurrent venous thromboembolism in women with a history of venous thrombosis. 4
15869590 2005
149
A single-centre prospective study of clinical and haemostatic risk factors for venous thromboembolism following lower limb arthroplasty. 4
15801960 2005
150
Thrombophilia and first arterial ischaemic stroke: a systematic review. 4
15781933 2005
151
Risk factors for thrombophilia in extrahepatic portal vein obstruction. 4
15726653 2005
152
A systematic review of the association between factor V Leiden or prothrombin gene variant and intrauterine growth restriction. 4
15746660 2005
153
Homocysteine, MTHFR and risk of venous thrombosis: a meta-analysis of published epidemiological studies. 4
15670035 2005
154
Malignancies, prothrombotic mutations, and the risk of venous thrombosis. 4
15701913 2005
155
Detection of prothrombin gene polymorphism at position 20209 (PT20209C/T): pilot study in a black population in the United Kingdom. 4
15630510 2005
156
Elevated levels of FVIII:C within families are associated with an increased risk for venous and arterial thrombosis. 4
15634269 2005
157
Genetic thrombophilias and preeclampsia: a meta-analysis. 4
15625161 2005
158
Progestogen-only contraception in women at high risk of venous thromboembolism. 4
15541404 2004
159
Meta-analysis of genetic studies in ischemic stroke: thirty-two genes involving approximately 18,000 cases and 58,000 controls. 4
15534175 2004
160
Paediatric cerebral sinus vein thrombosis. A multi-center, case-controlled study. 4
15467900 2004
161
Prothrombin 20210A mutation: a mild risk factor for venous thromboembolism but not for arterial thrombotic disease and pregnancy-related complications in a family study. 4
15451770 2004
162
Risk factors and recurrence rate of primary deep vein thrombosis of the upper extremities. 4
15262837 2004
163
Thrombophilia and pregnancy complications. 4
15343215 2004
164
Hormones and pregnancy: thromboembolic risks for women. 4
15287937 2004
165
Risk factors and clinical presentation of portal vein thrombosis in patients with liver cirrhosis. 4
15094219 2004
166
Factor V Leiden and prothrombin G20210A mutations in young adults with cryptogenic ischemic stroke. 4
15116266 2004
167
Thrombophilia and thrombotic problems in renal transplant patients. 4
15087754 2004
168
Evaluation of the association between hereditary thrombophilias and recurrent pregnancy loss: a meta-analysis. 4
15006834 2004
169
The contribution of factor V Leiden and prothrombin G20210A mutation to the risk of central venous catheter-related thrombosis. 4
15003896 2004
170
Factor V Leiden, prothrombin 20210G --> A, methylenetetrahydrofolate reductase 677C --> T and plasminogen activator inhibitor 4G/5G polymorphism in women with pregnancy-related venous thromboembolism. 4
14597244 2003
171
Allele 4G of gene PAI-1 associated with prothrombin mutation G20210A increases the risk for venous thrombosis. 4
14652637 2003
172
Risk of venous thromboembolism after air travel: interaction with thrombophilia and oral contraceptives. 4
14662632 2003
173
Pediatric venous thromboembolic disease in one single center: congenital prothrombotic disorders and the clinical outcome. 4
14675086 2003
174
Interaction between oral contraceptive use and coagulation factor levels in deep venous thrombosis. 4
14521603 2003
175
Inherited and acquired risk factors for venous thromboembolic disease among women taking tamoxifen to prevent breast cancer. 4
14512389 2003
176
Pregnancy-associated venous thromboembolism (VTE) in combined heterozygous factor V Leiden (FVL) and prothrombin (FII) 20210 A mutation and in heterozygous FII single gene mutation alone. 4
14531916 2003
177
Cerebral venous thrombosis in children: a multifactorial origin. 4
12939214 2003
178
Hyperhomocysteinemia in cerebral vein thrombosis. 4
12714502 2003
179
Is screening for factor V Leiden and prothrombin G20210A mutations in renal transplantation worthwhile? Results of a large single-center U.K. study. 4
12923451 2003
180
Hepatic artery thrombosis after liver transplantation and genetic factors: prothrombin G20210A polymorphism. 4
12865818 2003
181
Effect of hemostatic risk factors on the individual probability of thrombosis during pregnancy and the puerperium. 4
12876629 2003
182
Factor V Leiden and prothrombin gene G20210A mutation in children with cerebral thromboembolism. 4
12749008 2003
183
Prothrombotic conditions in an unselected cohort of children with venous thromboembolic disease. 4
12871356 2003
184
Clinical manifestations of the prothrombin G20210A mutation in children: a pediatric coagulation consortium study. 4
12871361 2003
185
Thromboprophylaxis improves the live birth rate in women with consecutive recurrent miscarriages and hereditary thrombophilia. 4
12871446 2003
186
Prothrombin G20210A mutation and oral contraceptive use increase upper-extremity deep vein thrombotic risk. 4
12624627 2003
187
Lupus anticoagulants are stronger risk factors for thrombosis than anticardiolipin antibodies in the antiphospholipid syndrome: a systematic review of the literature. 4
12393574 2003
188
Thrombophilic disorders and fetal loss: a meta-analysis. 4
12648968 2003
189
Prevalence of factor V Leiden, FII G20210A, FXIII Val34Leu and MTHFR C677T polymorphisms in cancer patients with and without venous thrombosis. 4
12757770 2003
190
The epidemiology of venous thromboembolism in Caucasians and African-Americans: the GATE Study. 4
12871543 2003
191
Venous thromboembolism, oral contraceptives and high prothrombin levels. 4
12871547 2003
192
Mid-trimester severe intrauterine growth restriction is associated with a high prevalence of thrombophilia. 4
12504973 2002
193
Factor V Leiden and factor II G20210A in preeclampsia and HELLP syndrome. 4
12519104 2002
194
Clinical and laboratory management of the prothrombin G20210A mutation. 4
12421139 2002
195
The incidence of venous thromboembolism in thrombophilic children: a prospective cohort study. 4
12239149 2002
196
Detection of a novel point mutation of the prothrombin gene at position 20209. 4
12218454 2002
197
Prothrombin A19911G and G20210A polymorphisms' role in thrombosis. 4
12139755 2002
198
Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial. 4
12117397 2002
199
Markers of activated coagulation in patients with factor V Leiden and/or G20210A prothrombin gene mutation. 4
12413582 2002
200
Absence of association of thrombophilia polymorphisms with intrauterine growth restriction. 4
12097536 2002
201
Venous thromboembolism in young women; role of thrombophilic mutations and oral contraceptive use. 4
12069454 2002
202
Inherited thrombophilia and first venous thromboembolism during pregnancy and puerperium. 4
12038778 2002
203
Third-trimester unexplained intrauterine fetal death is associated with inherited thrombophilia. 4
11978272 2002
204
Factor V Leiden (G1691A) and prothrombin gene G20210A mutations as potential risk factors for venous thromboembolism after total hip or total knee replacement surgery. 4
12008938 2002
205
No association of plasma prothrombin concentration or the G20210A mutation with incident cardiovascular disease: results from the Cardiovascular Health Study. 4
12008943 2002
206
The incidence of recurrent venous thromboembolism in carriers of factor V Leiden is related to concomitant thrombophilic disorders. 4
11849222 2002
207
Retinal artery occlusion in a patient with factor V Leiden and prothrombin G20210A mutations. 4
11994569 2002
208
Factor V Leiden and G20210A prothrombin mutations are risk factors for very early recurrent miscarriage. 4
11843387 2001
209
Contribution of prothrombin 20210A allele and factor V Leiden mutation to thrombosis risk in thrombophilic families with other hemostatic deficiencies. 4
11694407 2001
210
Combined effect of factor V Leiden and prothrombin 20210A on the risk of venous thromboembolism--pooled analysis of 8 case-control studies including 2310 cases and 3204 controls. Study Group for Pooled-Analysis in Venous Thromboembolism. 4
11583312 2001
211
Thrombophilic gene mutations and recurrent spontaneous abortion: prothrombin mutation increases the risk in the first trimester. 4
11506076 2001
212
Cerebral sinovenous thrombosis in children. 4
11496852 2001
213
The risk of recurrent venous thromboembolism among heterozygous carriers of the G20210A prothrombin gene mutation. 4
11380448 2001
214
Polymorphisms of clotting factors modify the risk for primary intracranial hemorrhage. 4
11342420 2001
215
Familial thrombophilia and the occurrence of fetal growth restriction. 4
11325651 2001
216
Hypercoagulable thrombophilic defects and hyperhomocysteinemia in patients with recurrent pregnancy loss. 4
11216876 2001
217
Risk of recurrent venous thrombosis in children with combined prothrombotic risk factors. 4
11159508 2001
218
Hormone replacement therapy, prothrombotic mutations, and the risk of incident nonfatal myocardial infarction in postmenopausal women. 4
11180734 2001
219
The risk of venous thromboembolism in family members with mutations in the genes of factor V or prothrombin or both. 4
11167765 2000
220
Safety of withholding heparin in pregnant women with a history of venous thromboembolism. Recurrence of Clot in This Pregnancy Study Group. 4
11078768 2000
221
Risk for subsequent venous thromboembolic complications in carriers of the prothrombin or the factor V gene mutation with a first episode of deep-vein thrombosis. 4
11071624 2000
222
High prevalence of the prothrombin gene mutation in women with intrauterine growth retardation, abruptio placentae and second trimester loss. 4
11081681 2000
223
Factor V Leiden mutation, prothrombin gene mutation, and deficiencies in coagulation inhibitors associated with Budd-Chiari syndrome and portal vein thrombosis: results of a case-control study. 4
11001884 2000
224
Mutations in coagulation factors in women with unexplained late fetal loss. 4
11018168 2000
225
High plasma levels of factor VIII and the risk of recurrent venous thromboembolism. 4
10950667 2000
226
Severe preeclampsia and high frequency of genetic thrombophilic mutations. 4
10862840 2000
227
Factor V Leiden and antiphospholipid antibodies are significant risk factors for ischemic stroke in children. 4
10835445 2000
228
High levels of factor IX increase the risk of venous thrombosis. 4
10845896 2000
229
Postmenopausal hormone therapy increases risk for venous thromboembolic disease. The Heart and Estrogen/progestin Replacement Study. 4
10787361 2000
230
Gestational outcome in thrombophilic women with recurrent pregnancy loss treated by enoxaparin. 4
10823264 2000
231
Linkage analysis demonstrates that the prothrombin G20210A mutation jointly influences plasma prothrombin levels and risk of thrombosis. 4
10779421 2000
232
The G20210A prothrombin polymorphism is not associated with increased thromboembolic risk in a large protein C deficient kindred. 4
10744139 2000
233
High levels of coagulation factor XI as a risk factor for venous thrombosis. 4
10706899 2000
234
Prothrombin and factor V mutations in women with a history of thrombosis during pregnancy and the puerperium. 4
10666427 2000
235
Higher risk of venous thrombosis during early use of oral contraceptives in women with inherited clotting defects. 4
10632304 2000
236
Factor V G1691A and prothrombin G20210A in childhood spontaneous venous thrombosis--evidence of an age-dependent thrombotic onset in carriers of factor V G1691A and prothrombin G20210A mutation. 4
10650846 1999
237
Coexistence of factor V Leiden and Factor II A20210 mutations and recurrent venous thromboembolism. 4
10613638 1999
238
The VITA project: prothrombin G20210A mutation and venous thromboembolism in the general population. 4
10595625 1999
239
"Normal" thrombin generation. 4
10498586 1999
240
Prothrombin G20210A gene mutation and further prothrombotic risk factors in childhood thrombophilia. 4
10521389 1999
241
Genetic risk factors for superficial vein thrombosis. 4
10544900 1999
242
The risk of recurrent deep venous thrombosis among heterozygous carriers of both factor V Leiden and the G20210A prothrombin mutation. 4
10477778 1999
243
Homozygotes for prothrombin gene 20210 A allele in a thrombophilic family without clinical manifestations of venous thromboembolism. 4
10406905 1999
244
The effect of raloxifene on risk of breast cancer in postmenopausal women: results from the MORE randomized trial. Multiple Outcomes of Raloxifene Evaluation. 4
10376571 1999
245
The risk of recurrent venous thromboembolism in carriers and non-carriers of the G1691A allele in the coagulation factor V gene and the G20210A allele in the prothrombin gene. DURAC Trial Study Group. Duration of Anticoagulation. 4
10365737 1999
246
Single and combined prothrombotic factors in patients with idiopathic venous thromboembolism: prevalence and risk assessment. 4
10073951 1999
247
Interaction between the G20210A mutation of the prothrombin gene and oral contraceptive use in deep vein thrombosis. 4
10073976 1999
248
G20210A mutation in prothrombin gene and risk of myocardial infarction, stroke, and venous thrombosis in a large cohort of US men. 4
10051291 1999
249
Study of the prothrombin gene 20201 GA variant in FV:Q506 carriers in relationship to the presence or absence of juvenile venous thromboembolism. 4
9974407 1999
250
Familial thrombophilia and the prothrombin 20210A mutation: association with increased thrombin generation and unusual thrombosis. 4
10070829 1999
251
The risk of early recurrent venous thromboembolism after oral anticoagulant therapy in patients with the G20210A transition in the prothrombin gene. 4
10348706 1999
252
The 20210 G-->A mutation in the 3'-untranslated region of the prothrombin gene and the risk for arterial thrombotic disease. 4
10027711 1999
253
Increased frequency of genetic thrombophilia in women with complications of pregnancy. 4
9878639 1999
254
Prothrombin antigen levels in symptomatic and asymptomatic carriers of the 20210A prothrombin variant. 4
9886317 1998
255
Prevalence of the prothrombin 20210 G-to-A variant in blacks: infants, patients with venous thrombosis, patients with myocardial infarction, and control subjects. 4
9851733 1998
256
Factor V Leiden and prothrombin gene G 20210 A variant in children with ischemic stroke. 4
9843168 1998
257
Genetic susceptibility to pregnancy-related venous thromboembolism: roles of factor V Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase C677T mutations. 4
9822524 1998
258
A single genetic origin for the common prothrombotic G20210A polymorphism in the prothrombin gene. 4
9694698 1998
259
Clinical studies and thrombin generation in patients homozygous or heterozygous for the G20210A mutation in the prothrombin gene. 4
9714136 1998
260
Prevalence of 20210 A allele of the prothrombin gene in venous thromboembolism patients. 4
9684784 1998
261
Increased risk for venous thrombosis in carriers of the prothrombin G-->A20210 gene variant. 4
9669991 1998
262
High risk of cerebral-vein thrombosis in carriers of a prothrombin-gene mutation and in users of oral contraceptives. 4
9632445 1998
263
Prothrombin G20210A mutant genotype is a risk factor for cerebrovascular ischemic disease in young patients. 4
9572989 1998
264
Geographic distribution of the 20210 G to A prothrombin variant. 4
9569177 1998
265
Association of a common polymorphism in the factor XIII gene with myocardial infarction. 4
9459313 1998
266
Co-inheritance of the 20210A allele of the prothrombin gene increases the risk of thrombosis in subjects with familial thrombophilia. 4
9423788 1997
267
The heterozygous 20210 G/A prothrombin genotype is associated with early venous thrombosis in inherited thrombophilias and is not increased in frequency in artery disease. 4
9409210 1997
268
A common prothrombin variant (20210 G to A) increases the risk of myocardial infarction in young women. 4
9292507 1997
269
A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. 4
8916933 1996
270
Role of clotting factor VIII in effect of von Willebrand factor on occurrence of deep-vein thrombosis. 4
7823669 1995
271
Prothrombin-Related Thrombophilia 38
20301327 2006

Variations for Prothrombin-Related Thrombophilia

Expression for Prothrombin-Related Thrombophilia

Search GEO for disease gene expression data for Prothrombin-Related Thrombophilia.

Pathways for Prothrombin-Related Thrombophilia

GO Terms for Prothrombin-Related Thrombophilia

Cellular components related to Prothrombin-Related Thrombophilia according to GeneCards Suite gene sharing:

(showing 1, show less)
# Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 8.62 F2 F13A1

Biological processes related to Prothrombin-Related Thrombophilia according to GeneCards Suite gene sharing:

(showing 2, show less)
# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 8.96 F2 F13A1
2 hemostasis GO:0007599 8.62 F2 F13A1

Molecular functions related to Prothrombin-Related Thrombophilia according to GeneCards Suite gene sharing:

(showing 1, show less)
# Name GO ID Score Top Affiliating Genes
1 serine-type peptidase activity GO:0008236 8.62 HABP2 F2

Sources for Prothrombin-Related Thrombophilia

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34 ICD10 via Orphanet
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