MCID: PRT005
MIFTS: 37

Protoplasmic Astrocytoma

Categories: Neuronal diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Protoplasmic Astrocytoma

MalaCards integrated aliases for Protoplasmic Astrocytoma:

Name: Protoplasmic Astrocytoma 12 59 15 73
Protoplasmic Astrocytic Tumor 12
Astrocytoma Protoplasmic 55

Characteristics:

Orphanet epidemiological data:

59
protoplasmic astrocytoma
Inheritance: Not applicable; Age of onset: Childhood;

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:7008
MeSH 44 D001254
NCIt 50 C4320
SNOMED-CT 68 55094006
Orphanet 59 ORPHA251598
UMLS via Orphanet 74 C0334580
ICD10 via Orphanet 34 C71.9
UMLS 73 C0334580

Summaries for Protoplasmic Astrocytoma

MalaCards based summary : Protoplasmic Astrocytoma, also known as protoplasmic astrocytic tumor, is related to fibrillary astrocytoma and astrocytoma, and has symptoms including headache, seizures and motor manifestations. An important gene associated with Protoplasmic Astrocytoma is PTGS2 (Prostaglandin-Endoperoxide Synthase 2), and among its related pathways/superpathways are TCR Signaling (Qiagen) and Development HGF signaling pathway. The drugs Cyproheptadine and Histamine have been mentioned in the context of this disorder. Affiliated tissues include brain, and related phenotypes are neoplasm and vision/eye

Related Diseases for Protoplasmic Astrocytoma

Diseases related to Protoplasmic Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Related Disease Score Top Affiliating Genes
1 fibrillary astrocytoma 30.9 GFAP IDH2 TP53
2 astrocytoma 10.4
3 oligoastrocytoma 10.2 GFAP IDH2
4 gemistocytic astrocytoma 10.2 GFAP IDH2
5 anaplastic oligodendroglioma 10.2 GFAP IDH2
6 intracranial chondrosarcoma 10.0 IDH2 TP53
7 epilepsy 10.0
8 glioma susceptibility 1 10.0 IDH2 TP53
9 brain stem glioma 9.9 IDH2 TP53
10 bile duct adenocarcinoma 9.9 IDH2 TP53
11 gastric adenosquamous carcinoma 9.9 SRC TP53
12 cerebral primitive neuroectodermal tumor 9.9 SRC TP53
13 signet ring cell adenocarcinoma 9.9 SRC TP53
14 esophageal disease 9.9 PTGS2 TP53
15 keratocystic odontogenic tumor 9.8 PTGS2 TP53
16 barrett's adenocarcinoma 9.8 PTGS2 TP53
17 gastrointestinal system benign neoplasm 9.8 PTGS2 TP53
18 frontal convexity meningioma 9.8 GFAP TP53
19 intestinal benign neoplasm 9.8 PTGS2 TP53
20 gliofibroma 9.8 GFAP TP53
21 cerebral convexity meningioma 9.8 GFAP TP53
22 cellular ependymoma 9.8 GFAP TP53
23 bladder squamous cell carcinoma 9.8 PTGS2 TP53
24 central nervous system primitive neuroectodermal neoplasm 9.8 GFAP TP53
25 cerebral neuroblastoma 9.8 GFAP TP53
26 mixed glioma 9.8 GFAP TP53
27 spinal cancer 9.8 GFAP TP53
28 ependymoblastoma 9.8 GFAP TP53
29 cerebral ventricle cancer 9.8 GFAP TP53
30 cerebrum cancer 9.8 GFAP TP53
31 actinic keratosis 9.8 PTGS2 TP53
32 chordoid glioma 9.8 GFAP TP53
33 integumentary system cancer 9.8 PTGS2 TP53
34 supratentorial cancer 9.8 GFAP TP53
35 malignant ependymoma 9.8 GFAP TP53
36 pleomorphic xanthoastrocytoma 9.8 GFAP TP53
37 gliomatosis cerebri 9.8 GFAP TP53
38 cervical adenocarcinoma 9.8 PTGS2 TP53
39 papilloma of choroid plexus 9.8 GFAP TP53
40 spinal cord astrocytoma 9.8 GFAP TP53
41 choroid plexus cancer 9.8 GFAP TP53
42 colorectal adenoma 9.8 PTGS2 TP53
43 necrotizing sialometaplasia 9.8 GFAP TP53
44 cystic teratoma 9.8 GFAP TP53
45 cerebellar liponeurocytoma 9.8 GFAP TP53
46 esophagitis 9.8 PTGS2 TP53
47 ductal carcinoma in situ 9.7 PTGS2 TP53
48 medullomyoblastoma 9.7 GFAP TP53
49 ureteral obstruction 9.7 PTGS2 TP53
50 brain glioma 9.7 GFAP TP53

Graphical network of the top 20 diseases related to Protoplasmic Astrocytoma:



Diseases related to Protoplasmic Astrocytoma

Symptoms & Phenotypes for Protoplasmic Astrocytoma

UMLS symptoms related to Protoplasmic Astrocytoma:


headache, seizures, motor manifestations, sensory manifestations

MGI Mouse Phenotypes related to Protoplasmic Astrocytoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.26 IDH2 PTGS2 SRC TP53
2 vision/eye MP:0005391 8.92 GFAP PTGS2 SRC TP53

Drugs & Therapeutics for Protoplasmic Astrocytoma

Drugs for Protoplasmic Astrocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyproheptadine Approved Phase 3 129-03-3 2913
2
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
3 Dermatologic Agents Phase 3,Phase 1
4
Histamine Phosphate Phase 3 51-74-1 65513
5 Serotonin Agents Phase 3
6 Serotonin Antagonists Phase 3
7 Gastrointestinal Agents Phase 3,Not Applicable
8 Neurotransmitter Agents Phase 3,Not Applicable
9 Histamine Antagonists Phase 3
10 Histamine H1 Antagonists Phase 3
11 Anti-Allergic Agents Phase 3
12 Antipruritics Phase 3
13
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
14
Crizotinib Approved Phase 1, Phase 2 877399-52-5 11626560 10366136 10366137 10366138 10366139 10366140 10366141
15 Protein Kinase Inhibitors Phase 1, Phase 2
16
Verteporfin Approved, Investigational Phase 1 129497-78-5
17
Trioxsalen Approved Phase 1 3902-71-4 5585
18 Dihematoporphyrin Ether Phase 1
19 Photosensitizing Agents Phase 1
20
Dopamine Approved Not Applicable 51-61-6, 62-31-7 681
21 Fluorides Not Applicable
22 Dihydroxyphenylalanine Not Applicable
23 Dopamine Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
2 Crizotinib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Anaplastic Large Cell Lymphoma Active, not recruiting NCT00939770 Phase 1, Phase 2 crizotinib
3 Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors Unknown status NCT00002647 Phase 1 verteporfin
4 Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or Lymphoma Completed NCT01273090 Phase 1 imetelstat sodium
5 18F-FDOPA PET/CT or PET/MRI in Measuring Tumors in Patients With Newly-Diagnosed or Recurrent Gliomas Terminated NCT02175745 Not Applicable 18F-fluoro-dihydroxyphenylalanine
6 Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors Withdrawn NCT02194452 Not Applicable

Search NIH Clinical Center for Protoplasmic Astrocytoma

Genetic Tests for Protoplasmic Astrocytoma

Anatomical Context for Protoplasmic Astrocytoma

MalaCards organs/tissues related to Protoplasmic Astrocytoma:

41
Brain

Publications for Protoplasmic Astrocytoma

Articles related to Protoplasmic Astrocytoma:

# Title Authors Year
1
Diffuse central nervous system protoplasmic astrocytoma. ( 20049933 )
2010
2
Cyclooxygenase-2, Bcl-2, and chromosome 1p analysis in protoplasmic astrocytomas. ( 15017587 )
2004
3
Protoplasmic astrocytoma. A clinicopathologic study of 16 tumors. ( 7785654 )
1995
4
Protoplasmic astrocytoma: cytologic features on tissue imprint preparation. ( 1638945 )
1992
5
Protoplasmic astrocytoma: an angiographic case report. ( 5544526 )
1971
6
Epilepsy incident to protoplasmic astrocytoma; report of a case. ( 18115670 )
1949

Variations for Protoplasmic Astrocytoma

Expression for Protoplasmic Astrocytoma

Search GEO for disease gene expression data for Protoplasmic Astrocytoma.

Pathways for Protoplasmic Astrocytoma

GO Terms for Protoplasmic Astrocytoma

Cellular components related to Protoplasmic Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 caveola GO:0005901 8.62 PTGS2 SRC

Biological processes related to Protoplasmic Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.61 PTGS2 SRC TP53
2 positive regulation of apoptotic process GO:0043065 9.5 PTGS2 SRC TP53
3 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.46 SRC TP53
4 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 9.4 PTGS2 SRC
5 cellular response to UV GO:0034644 9.37 PTGS2 TP53
6 response to fatty acid GO:0070542 9.26 PTGS2 SRC
7 cellular response to fluid shear stress GO:0071498 9.16 PTGS2 SRC
8 negative regulation of telomerase activity GO:0051974 8.96 SRC TP53
9 cellular response to hypoxia GO:0071456 8.8 PTGS2 SRC TP53

Molecular functions related to Protoplasmic Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kinase binding GO:0019900 8.96 GFAP SRC
2 enzyme binding GO:0019899 8.8 PTGS2 SRC TP53

Sources for Protoplasmic Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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