MCID: PRT005
MIFTS: 38

Protoplasmic Astrocytoma

Categories: Cancer diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Protoplasmic Astrocytoma

MalaCards integrated aliases for Protoplasmic Astrocytoma:

Name: Protoplasmic Astrocytoma 12 59 15 73
Protoplasmic Astrocytic Tumor 12
Astrocytoma Protoplasmic 55

Characteristics:

Orphanet epidemiological data:

59
protoplasmic astrocytoma
Inheritance: Not applicable; Age of onset: Childhood;

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:7008
MeSH 44 D001254
NCIt 50 C4320
SNOMED-CT 68 55094006
Orphanet 59 ORPHA251598
UMLS via Orphanet 74 C0334580
ICD10 via Orphanet 34 C71.9
UMLS 73 C0334580

Summaries for Protoplasmic Astrocytoma

MalaCards based summary : Protoplasmic Astrocytoma, also known as protoplasmic astrocytic tumor, is related to fibrillary astrocytoma and astrocytoma, and has symptoms including seizures, headache and motor manifestations. An important gene associated with Protoplasmic Astrocytoma is PTGS2 (Prostaglandin-Endoperoxide Synthase 2), and among its related pathways/superpathways are Development HGF signaling pathway and Colorectal Cancer Metastasis. The drugs Histamine and Cyproheptadine have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and colon, and related phenotype is neoplasm.

Related Diseases for Protoplasmic Astrocytoma

Diseases related to Protoplasmic Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 108)
# Related Disease Score Top Affiliating Genes
1 fibrillary astrocytoma 32.1 GFAP IDH2 TP53
2 astrocytoma 10.5
3 oligoastrocytoma 10.1 GFAP IDH2
4 epilepsy 10.1
5 gemistocytic astrocytoma 10.1 GFAP IDH2
6 anaplastic oligodendroglioma 10.1 GFAP IDH2
7 intracranial chondrosarcoma 10.1 IDH2 TP53
8 mandibular cancer 10.1 GFAP SMUG1
9 testis seminoma 10.1 GFAP SMUG1
10 esophagus adenocarcinoma 10.1 PTGS2 TP53
11 cogan syndrome 10.1 GFAP SMUG1
12 bile duct adenocarcinoma 10.1 IDH2 TP53
13 nervous system cancer 10.1 GFAP TP53
14 frontal convexity meningioma 10.1 GFAP TP53
15 gliofibroma 10.1 GFAP TP53
16 bartholin's duct cyst 10.1 SMUG1 TP53
17 cerebral convexity meningioma 10.1 GFAP TP53
18 malignant spiradenoma 10.1 SMUG1 TP53
19 meninges sarcoma 10.1 GFAP TP53
20 colloid adenoma 10.1 SMUG1 TP53
21 central nervous system primitive neuroectodermal neoplasm 10.1 GFAP TP53
22 keratocystic odontogenic tumor 10.1 PTGS2 TP53
23 cerebral neuroblastoma 10.0 GFAP TP53
24 mixed glioma 10.0 GFAP TP53
25 spinal cancer 10.0 GFAP TP53
26 ependymoblastoma 10.0 GFAP TP53
27 cerebral ventricle cancer 10.0 GFAP TP53
28 gastrointestinal system benign neoplasm 10.0 PTGS2 TP53
29 chordoid glioma 10.0 GFAP TP53
30 mature teratoma 10.0 SMUG1 TP53
31 teratoma 10.0 GFAP TP53
32 barrett's adenocarcinoma 10.0 PTGS2 TP53
33 malignant ependymoma 10.0 GFAP TP53
34 prostate squamous cell carcinoma 10.0 SMUG1 TP53
35 benign glioma 10.0 GFAP TP53
36 pleomorphic xanthoastrocytoma 10.0 GFAP TP53
37 brain stem glioma 10.0 IDH2 TP53
38 spinal cord astrocytoma 10.0 GFAP TP53
39 intestinal benign neoplasm 10.0 PTGS2 TP53
40 central nervous system hematologic cancer 10.0 SMUG1 TP53
41 gliomatosis cerebri 10.0 GFAP TP53
42 papilloma of choroid plexus 10.0 GFAP TP53
43 choroid plexus cancer 10.0 GFAP TP53
44 necrotizing sialometaplasia 10.0 GFAP TP53
45 cystic teratoma 10.0 GFAP TP53
46 central nervous system benign neoplasm 10.0 GFAP TP53
47 nervous system benign neoplasm 10.0 GFAP TP53
48 cerebellar liponeurocytoma 10.0 GFAP TP53
49 xanthogranulomatous cholecystitis 10.0 SMUG1 TP53
50 medullomyoblastoma 10.0 GFAP TP53

Graphical network of the top 20 diseases related to Protoplasmic Astrocytoma:



Diseases related to Protoplasmic Astrocytoma

Symptoms & Phenotypes for Protoplasmic Astrocytoma

UMLS symptoms related to Protoplasmic Astrocytoma:


seizures, headache, motor manifestations, sensory manifestations

MGI Mouse Phenotypes related to Protoplasmic Astrocytoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.02 IDH2 PTGS2 SMUG1 SRC TP53

Drugs & Therapeutics for Protoplasmic Astrocytoma

Drugs for Protoplasmic Astrocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 3 51-45-6, 75614-87-8 774
2
Cyproheptadine Approved Phase 3 129-03-3 2913
3 Dermatologic Agents Phase 3,Phase 1
4 Serotonin Agents Phase 3
5 Anti-Allergic Agents Phase 3
6 Serotonin Antagonists Phase 3
7 Histamine H1 Antagonists Phase 3
8
Histamine Phosphate Phase 3 51-74-1 65513
9 Antipruritics Phase 3
10 Neurotransmitter Agents Phase 3,Not Applicable
11 Histamine Antagonists Phase 3
12 Gastrointestinal Agents Phase 3,Not Applicable
13
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
14
Verteporfin Approved, Investigational Phase 1 129497-78-5
15
Trioxsalen Approved Phase 1 3902-71-4 5585
16 Photosensitizing Agents Phase 1
17 Dihematoporphyrin Ether Phase 1
18
Dopamine Approved Not Applicable 51-61-6, 62-31-7 681
19 Dopamine Agents Not Applicable
20 Dihydroxyphenylalanine Not Applicable
21 Fluorides Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
2 Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors Unknown status NCT00002647 Phase 1 verteporfin
3 Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or Lymphoma Completed NCT01273090 Phase 1 imetelstat sodium
4 18F-FDOPA PET/CT or PET/MRI in Measuring Tumors in Patients With Newly-Diagnosed or Recurrent Gliomas Terminated NCT02175745 Not Applicable 18F-fluoro-dihydroxyphenylalanine
5 Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors Withdrawn NCT02194452 Not Applicable

Search NIH Clinical Center for Protoplasmic Astrocytoma

Genetic Tests for Protoplasmic Astrocytoma

Anatomical Context for Protoplasmic Astrocytoma

MalaCards organs/tissues related to Protoplasmic Astrocytoma:

41
Brain, Lung, Colon, Spinal Cord, Pancreas, Testis, Thymus

Publications for Protoplasmic Astrocytoma

Articles related to Protoplasmic Astrocytoma:

# Title Authors Year
1
Protoplasmic astrocytoma with multifocal involvement: case report and radiological findings. ( 30363198 )
2015
2
Diffuse central nervous system protoplasmic astrocytoma. ( 20049933 )
2010
3
Protoplasmic astrocytoma. A clinicopathologic study of 16 tumors. ( 7785654 )
1995
4
Protoplasmic astrocytoma: cytologic features on tissue imprint preparation. ( 1638945 )
1992
5
Protoplasmic astrocytoma: an angiographic case report. ( 5544526 )
1971
6
Epilepsy incident to protoplasmic astrocytoma; report of a case. ( 18115670 )
1949

Variations for Protoplasmic Astrocytoma

Expression for Protoplasmic Astrocytoma

Search GEO for disease gene expression data for Protoplasmic Astrocytoma.

Pathways for Protoplasmic Astrocytoma

GO Terms for Protoplasmic Astrocytoma

Cellular components related to Protoplasmic Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 caveola GO:0005901 8.62 PTGS2 SRC

Biological processes related to Protoplasmic Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.54 PTGS2 SRC TP53
2 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 9.43 PTGS2 SRC
3 cellular response to UV GO:0034644 9.4 PTGS2 TP53
4 base-excision repair GO:0006284 9.32 SMUG1 TP53
5 response to fatty acid GO:0070542 9.26 PTGS2 SRC
6 cellular response to fluid shear stress GO:0071498 9.16 PTGS2 SRC
7 negative regulation of telomerase activity GO:0051974 8.96 SRC TP53
8 cellular response to hypoxia GO:0071456 8.8 PTGS2 SRC TP53

Molecular functions related to Protoplasmic Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 8.8 PTGS2 SRC TP53

Sources for Protoplasmic Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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