MCID: PRT005
MIFTS: 34

Protoplasmic Astrocytoma

Categories: Cancer diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Protoplasmic Astrocytoma

MalaCards integrated aliases for Protoplasmic Astrocytoma:

Name: Protoplasmic Astrocytoma 12 60 15 74
Protoplasmic Astrocytic Tumor 12
Astrocytoma Protoplasmic 56

Characteristics:

Orphanet epidemiological data:

60
protoplasmic astrocytoma
Inheritance: Not applicable; Age of onset: Childhood;

Classifications:

Orphanet: 60  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:7008
MeSH 45 D001254
NCIt 51 C4320
SNOMED-CT 69 55094006
ICD10 via Orphanet 35 C71.9
UMLS via Orphanet 75 C0334580
Orphanet 60 ORPHA251598
UMLS 74 C0334580

Summaries for Protoplasmic Astrocytoma

MalaCards based summary : Protoplasmic Astrocytoma, also known as protoplasmic astrocytic tumor, is related to fibrillary astrocytoma and astrocytoma, and has symptoms including seizures, headache and motor manifestations. An important gene associated with Protoplasmic Astrocytoma is PTGS2 (Prostaglandin-Endoperoxide Synthase 2), and among its related pathways/superpathways are Colorectal Cancer Metastasis and Spinal Cord Injury. The drugs Cyproheptadine and Histamine have been mentioned in the context of this disorder. Affiliated tissues include brain, and related phenotype is neoplasm.

Related Diseases for Protoplasmic Astrocytoma

Graphical network of the top 20 diseases related to Protoplasmic Astrocytoma:



Diseases related to Protoplasmic Astrocytoma

Symptoms & Phenotypes for Protoplasmic Astrocytoma

UMLS symptoms related to Protoplasmic Astrocytoma:


seizures, headache, motor manifestations, sensory manifestations

MGI Mouse Phenotypes related to Protoplasmic Astrocytoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.92 IDH2 PTGS2 SMUG1 SRC

Drugs & Therapeutics for Protoplasmic Astrocytoma

Drugs for Protoplasmic Astrocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyproheptadine Approved Phase 3 129-03-3 2913
2
Histamine Approved, Investigational Phase 3 51-45-6 774
3 Dermatologic Agents Phase 3,Phase 1
4
Histamine Phosphate Phase 3 51-74-1 65513
5 Anti-Allergic Agents Phase 3
6 Neurotransmitter Agents Phase 3,Not Applicable
7 Histamine H1 Antagonists Phase 3
8 Serotonin Agents Phase 3
9 Serotonin Antagonists Phase 3
10 Antipruritics Phase 3
11 Gastrointestinal Agents Phase 3,Not Applicable
12 Histamine Antagonists Phase 3
13
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
14
Trioxsalen Approved Phase 1 3902-71-4 5585
15
Verteporfin Approved, Investigational Phase 1 129497-78-5
16
Nicotinamide Approved, Investigational Phase 1 98-92-0 936
17
Niacin Approved, Investigational, Nutraceutical Phase 1 59-67-6 938
18
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1 59-30-3 6037
19 Photosensitizing Agents Phase 1
20 Dihematoporphyrin Ether Phase 1
21 Protein Kinase Inhibitors Phase 1
22
Imetelstat Phase 1
23 Vitamins Phase 1
24 Nicotinic Acids Phase 1
25 Trace Elements Phase 1
26 Nutrients Phase 1
27 Vitamin B Complex Phase 1
28 Vitamin B3 Phase 1
29 Folate Phase 1
30 Vitamin B9 Phase 1
31 Micronutrients Phase 1
32
Motesanib diphosphate Phase 1 850649-62-6 11450633
33
Dopamine Approved Not Applicable 62-31-7, 51-61-6 681
34 Fluorides Not Applicable
35 Dopamine Agents Not Applicable
36 Dihydroxyphenylalanine Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
2 Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors Unknown status NCT00002647 Phase 1 verteporfin
3 Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or Lymphoma Completed NCT01273090 Phase 1 imetelstat sodium
4 18F-FDOPA PET/CT or PET/MRI in Measuring Tumors in Patients With Newly-Diagnosed or Recurrent Gliomas Terminated NCT02175745 Not Applicable 18F-fluoro-dihydroxyphenylalanine
5 Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors Withdrawn NCT02194452 Not Applicable

Search NIH Clinical Center for Protoplasmic Astrocytoma

Genetic Tests for Protoplasmic Astrocytoma

Anatomical Context for Protoplasmic Astrocytoma

MalaCards organs/tissues related to Protoplasmic Astrocytoma:

42
Brain

Publications for Protoplasmic Astrocytoma

Articles related to Protoplasmic Astrocytoma:

# Title Authors Year
1
Protoplasmic astrocytoma with multifocal involvement: case report and radiological findings. ( 30363198 )
2015
2
Diffuse central nervous system protoplasmic astrocytoma. ( 20049933 )
2010
3
Protoplasmic astrocytoma. A clinicopathologic study of 16 tumors. ( 7785654 )
1995
4
Protoplasmic astrocytoma: cytologic features on tissue imprint preparation. ( 1638945 )
1992
5
Protoplasmic astrocytoma: an angiographic case report. ( 5544526 )
1971
6
Epilepsy incident to protoplasmic astrocytoma; report of a case. ( 18115670 )
1949

Variations for Protoplasmic Astrocytoma

Expression for Protoplasmic Astrocytoma

Search GEO for disease gene expression data for Protoplasmic Astrocytoma.

Pathways for Protoplasmic Astrocytoma

Pathways related to Protoplasmic Astrocytoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.47 PTGS2 SRC
2 11.23 GFAP PTGS2
3
Show member pathways
11.02 PTGS2 SRC
4 10.3 PTGS2 SRC

GO Terms for Protoplasmic Astrocytoma

Cellular components related to Protoplasmic Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 caveola GO:0005901 8.62 PTGS2 SRC

Biological processes related to Protoplasmic Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to hypoxia GO:0071456 9.26 PTGS2 SRC
2 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 9.16 PTGS2 SRC
3 response to fatty acid GO:0070542 8.96 PTGS2 SRC
4 cellular response to fluid shear stress GO:0071498 8.62 PTGS2 SRC

Molecular functions related to Protoplasmic Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 9.16 PTGS2 SRC
2 integrin binding GO:0005178 8.96 GFAP SRC
3 kinase binding GO:0019900 8.62 GFAP SRC

Sources for Protoplasmic Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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