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MCID: PRR013
MIFTS: 40

Prurigo Nodularis

Categories: Rare diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Prurigo Nodularis

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MalaCards integrated aliases for Prurigo Nodularis:

Name: Prurigo Nodularis 53 55 73
Nodular Prurigo 53

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Skin diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

ICD10 33 L28.1
UMLS 73 C0263353
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Summaries for Prurigo Nodularis

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NIH Rare Diseases : 53 Prurigo nodularis (PN) is a skin disease that causes hard, itchy lumps (nodules) to form on the skin. The itching (pruritus) can be intense, causing people to scratch themselves to the point of bleeding or pain. Scratching can cause more skin lesions to appear. The itching is worsened by heat, sweating, or irritation from clothing. In some cases, people with PN have a history of other diseases including eczema (atopic dermatitis), lymphoma, HIV infection, severe anemia, or kidney disease.  The exact cause of PN is unknown. Although scratching is known to cause more nodules to appear, it is unclear what causes the itching to develop in the first place. Diagnosis of the disease is based on observing signs such as extremely itchy skin with the formation of nodules. In some cases, a skin biopsy is used to confirm the diagnosis. Treatment may include corticosteroid creams, oral medications, cryotherapy, or photochemotherapy.

MalaCards based summary : Prurigo Nodularis, also known as nodular prurigo, is related to peripheral nervous system disease and amyloidosis, primary localized cutaneous, 1. An important gene associated with Prurigo Nodularis is RNASE3 (Ribonuclease A Family Member 3), and among its related pathways/superpathways are Phospholipase-C Pathway and p70S6K Signaling. The drugs Lidocaine and Peripheral Nervous System Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and tonsil.

Wikipedia : 76 Prurigo nodularis (PN), also known as nodular prurigo, is a skin disease characterised by pruritic... more...

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Related Diseases for Prurigo Nodularis

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Diseases related to Prurigo Nodularis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 91)
# Related Disease Score Top Affiliating Genes
1 peripheral nervous system disease 29.5 NGF TAC1
2 amyloidosis, primary localized cutaneous, 1 11.2
3 epidermolysis bullosa pruriginosa 11.2
4 amyloidosis, primary localized cutaneous, 2 11.2
5 amyloidosis, primary localized cutaneous, 3 11.2
6 dermatitis 10.4
7 lymphoma 10.4
8 hepatitis 10.3
9 bullous pemphigoid 10.3
10 neuropathy 10.3
11 lymphoma, hodgkin, classic 10.2
12 contact dermatitis 10.2
13 allergic contact dermatitis 10.2
14 keratoacanthoma 10.2
15 neurodermatitis 10.2
16 uremia 10.2
17 herpes zoster 10.2
18 lichen planus 10.2
19 linear iga disease 10.2
20 depression 10.2
21 hashimoto thyroiditis 10.1
22 celiac disease 1 10.1
23 dermatitis herpetiformis, familial 10.1
24 psoriasis 2 10.1
25 lymphoma, non-hodgkin, familial 10.1
26 psoriasis 7 10.1
27 anxiety 10.1
28 psoriasis 11 10.1
29 alpha-1-antitrypsin deficiency 10.1
30 gastric cancer 10.1
31 psoriasis 13 10.1
32 burns 10.1
33 chronic kidney failure 10.1
34 hemangioma 10.1
35 colitis 10.1
36 collagenous colitis 10.1
37 filariasis 10.1
38 skin epithelioid hemangioma 10.1
39 squamous cell carcinoma 10.1
40 hepatitis c 10.1
41 neuroma 10.1
42 transitional cell carcinoma 10.1
43 porokeratosis 10.1
44 bladder urothelial carcinoma 10.1
45 human immunodeficiency virus infectious disease 10.1
46 kidney disease 10.1
47 thyroiditis 10.1
48 scabies 10.1
49 dermatitis herpetiformis 10.1
50 vasculitis 10.1

Graphical network of the top 20 diseases related to Prurigo Nodularis:



Diseases related to Prurigo Nodularis
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Symptoms & Phenotypes for Prurigo Nodularis

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Drugs & Therapeutics for Prurigo Nodularis

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Drugs for Prurigo Nodularis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 63)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
2 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
3 Central Nervous System Depressants Phase 4,Phase 2,Phase 3
4 Anesthetics, Local Phase 4
5 Anesthetics Phase 4
6 Diuretics, Potassium Sparing Phase 4
7 Sodium Channel Blockers Phase 4
8 Anti-Arrhythmia Agents Phase 4
9
Nalbuphine Approved Phase 2, Phase 3,Phase 3 20594-83-6 5311304 5360630
10 Serlopitant Investigational Phase 3,Phase 2 860642-69-9
11
Substance P Investigational Phase 3,Phase 2 33507-63-0 44359816
12 Neurotransmitter Agents Phase 3,Phase 2,Not Applicable
13 Narcotic Antagonists Phase 2, Phase 3,Phase 3
14 Analgesics, Opioid Phase 2, Phase 3,Phase 3
15 Analgesics Phase 2, Phase 3,Phase 3,Phase 1
16 Antipruritics Phase 2, Phase 3,Phase 3,Phase 1
17 Narcotics Phase 2, Phase 3,Phase 3
18 Neurokinin-1 Receptor Antagonists Phase 3,Phase 2
19 neurokinin A Phase 3,Phase 2
20
Apremilast Approved, Investigational Phase 2,Phase 1 608141-41-9 11561674
21
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754
22
Hydrocortisone acetate Approved, Vet_approved Phase 2 50-03-3
23
Tacrolimus Approved, Investigational Phase 2 104987-11-3 445643 439492
24
Pimecrolimus Approved, Investigational Phase 2 137071-32-0 6447131 17753757
25 Anti-Infective Agents Phase 2,Phase 1,Not Applicable
26 Anti-Bacterial Agents Phase 2,Phase 1,Not Applicable
27 Analgesics, Non-Narcotic Phase 2,Phase 1
28 Angiogenesis Inhibitors Phase 2,Phase 1
29 Immunologic Factors Phase 2,Phase 1
30 Immunosuppressive Agents Phase 2,Phase 1
31 Anti-Inflammatory Agents Phase 2,Phase 1
32 Angiogenesis Modulating Agents Phase 2,Phase 1
33 Anti-Inflammatory Agents, Non-Steroidal Phase 2,Phase 1
34 Antirheumatic Agents Phase 2,Phase 1
35 Hydrocortisone 17-butyrate 21-propionate Phase 2
36 Hydrocortisone-17-butyrate Phase 2
37 Calcineurin Inhibitors Phase 2
38 Dermatologic Agents Phase 2,Phase 1
39 Cortisol succinate Phase 2
40
Citalopram Approved Not Applicable 59729-33-8 2771
41
leucovorin Approved Not Applicable 58-05-9 6006 143
42
Dapsone Approved, Investigational Not Applicable 80-08-0 2955
43
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
44 Autonomic Agents Not Applicable
45 Neurotransmitter Uptake Inhibitors Not Applicable
46 Cholinergic Agents Not Applicable
47 Psychotropic Drugs Not Applicable
48 Antidepressive Agents Not Applicable
49 Antidepressive Agents, Second-Generation Not Applicable
50 Cholinergic Antagonists Not Applicable

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Pain Outcomes Following Intralesional Corticosteroid Injections Not yet recruiting NCT03630198 Phase 4 Corticosteroid with lidocaine;Corticosteroid with normal saline
2 Study of Nalbuphine HCl ER Tablets in Patients With Prurigo Nodularis Completed NCT02174419 Phase 2, Phase 3 nalbuphine HCl ER tablets 90 mg BID;nalbuphine HCl ER tablets 180 mg BID;Placebo tablets BID
3 Open Label Extension Study of Nalbuphine HCl ER in Patients With Prurigo Nodularis Completed NCT02174432 Phase 2, Phase 3 nalbuphine HCl ER 90 mg BID;nalbuphine HCl ER 120 mg BID;nalbuphine HCl ER 180 mg BID
4 Study of the Efficacy, Safety and Tolerability of Serlopitant for the Treatment of Pruritus (Itch) With Prurigo Nodularis Recruiting NCT03677401 Phase 3 5mg Serlopitant Tablets;Placebo Tablets
5 Study of the Efficacy, Safety and Tolerability of Serlopitant for the Treatment of Pruritus (Itch) With Prurigo Nodularis Recruiting NCT03546816 Phase 3 5mg Serlopitant Tablets;Placebo Tablets
6 PRISM Study-Pruritus Relief Through Itch Scratch Modulation Recruiting NCT03497975 Phase 2, Phase 3 Nalbuphine ER Tablets
7 Study of the Long Term Safety of Serlopitant for the Treatment of Pruritus (Itch) Recruiting NCT03540160 Phase 3 5 mg Serlopitant Tablets
8 A Randomized Placebo-Controlled Study of the Neurokinin-1 (NK1) Receptor Antagonist Serlopitant Prurigo Nodularis (PN) Completed NCT02196324 Phase 2 serlopitant;Placebo
9 Safety and Efficacy of CC-10004 for Prurigo Nodularis Completed NCT00869089 Phase 2 CC-10004
10 Evaluation of the Antipruritic Effect of Elidel (Pimecrolimus) in Non-atopic Pruritic Disease Completed NCT00507832 Phase 2 Pimecrolimus;Hydrocortisone;Pimecrolimus
11 Apremilast as Anti-pruritic Treatment in Patients With Prurigo Nodularis Recruiting NCT03576287 Phase 1, Phase 2 Apremilast Oral Product
12 A Study to Assess the Efficacy, Safety, and Tolerability of KPL-716 in Reducing Pruritus in Prurigo Nodularis Not yet recruiting NCT03816891 Phase 2 KPL-716;Placebo
13 Safety and Efficacy of Nemolizumab in PN Not yet recruiting NCT03181503 Phase 2 CD14152 Dose A;CD14152 placebo
14 Effectiveness of the Selective Serotonin Reuptake Inhibitor,Citalopram (Cipralex), in Prurigo Nodularis Unknown status NCT00532519 Not Applicable citalopram (cipralex)
15 Dapsone Prurigo Study Not yet recruiting NCT01870050 Not Applicable Dapsone gel - verum

Search NIH Clinical Center for Prurigo Nodularis

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Genetic Tests for Prurigo Nodularis

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Anatomical Context for Prurigo Nodularis

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MalaCards organs/tissues related to Prurigo Nodularis:

41
Skin, Kidney, Tonsil, Testes, Endothelial, Thyroid, T Cells
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Publications for Prurigo Nodularis

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Articles related to Prurigo Nodularis:

(show top 50) (show all 230)
# Title Authors Year
1
The use of biodegradable microneedle patches to increase penetration of topical steroid for prurigo nodularis. ( 29521638 )
2018
2
Ethnic differences and comorbidities of 909 Prurigo Nodularis patients. ( 29733939 )
2018
3
Prurigo Nodularis and Its Management. ( 29929592 )
2018
4
Generalized eruptive keratoacanthoma with vitiligo followed by the development of prurigo nodularis: A case report and published work review. ( 29058335 )
2018
5
Thalidomide for the treatment of chronic refractory prurigo nodularis. ( 29634881 )
2018
6
Rapid improvement of prurigo nodularis with cyclosporine treatment. ( 29438756 )
2018
7
Allergic contact dermatitis due to chloramphenicol with prurigo nodularis-like spreading. ( 30485440 )
2018
8
Prurigo nodularis: a physician survey to evaluate current perceptions of its classification, clinical experience and unmet need. ( 29869425 )
2018
9
Comprehending prurigo nodularis: Ay, there's the rub. ( 30092325 )
2018
10
Xerosis cutis and associated co-factors in women with prurigo nodularis. ( 30156616 )
2018
11
Prurigo Nodularis after Radiotherapy: An Isoradiotopic Response? ( 30245894 )
2018
12
The Prevalence of Psychiatric Comorbidity in Patients with Prurigo Nodularis. ( 30258799 )
2018
13
A Systematic Review of Evidence-Based Treatments for Prurigo Nodularis. ( 30261199 )
2018
14
Reduced Itch Associated With Dupilumab Treatment In 4 Patients With Prurigo Nodularis. ( 30427989 )
2018
15
Dupilumab Treatment for Generalized Prurigo Nodularis. ( 30427994 )
2018
16
There is no functional small-fibre neuropathy in prurigo nodularis despite neuroanatomical alterations. ( 28370394 )
2017
17
Acquired elastotic hemangioma-like changes and eccrine sweat duct squamous metaplasia in lichen simplex chronicus/prurigo nodularis-like lesions of the knee and elbow. ( 28374436 )
2017
18
Prurigo Nodularis ( 29083653 )
2017
19
Use of Isoquercetin in the Treatment of Prurigo Nodularis. ( 29141065 )
2017
20
Acquired Reactive Perforating Dermatosis is a Variant of Prurigo Nodularis. ( 27349279 )
2016
21
Hypertrophic lichen planus versus prurigo nodularis: a dermoscopic perspective. ( 27222766 )
2016
22
Treatment of prurigo nodularis with lenalidomide. ( 27891738 )
2016
23
Phototherapy for the treatment of prurigo nodularis: a review. ( 27617458 )
2016
24
Treatment of prurigo nodularis with dexamethasone-cyclophosphamide pulse therapy. ( 26924412 )
2016
25
Aspirin and loxoprofen relieve refractory pruritus in patients with prurigo nodularis. ( 26970197 )
2016
26
Treatment of prurigo nodularis with dexamethasone-cyclophosphamide pulse therapy. ( 26858054 )
2016
27
A Review of the Efficacy of Thalidomide and Lenalidomide in the Treatment of Refractory Prurigo Nodularis. ( 27289372 )
2016
28
Anxiety, depression and suicide in patients with prurigo nodularis. ( 27505149 )
2016
29
Bullous pemphigoid developed in a patient with prurigo nodularis. ( 27511319 )
2016
30
Systemic methotrexate for prurigo nodularis and keratoacanthomas in actinically damaged skin. ( 27486591 )
2016
31
Prurigo Nodularis Management. ( 27578077 )
2016
32
Successful use of a modified Goeckerman regimen in the treatment of generalized prurigo nodularis. ( 25497953 )
2015
33
Intraepidermal Nerve Fibre Density is Decreased in Lesional and Inter-lesional Prurigo Nodularis and Reconstitutes on Healing of Lesions. ( 26338533 )
2015
34
Prurigo nodularis: Picking the right treatment. ( 25973448 )
2015
35
Serotonin and interleukin-6: Association with pruritus severity, sleep quality and depression severity in Prurigo Nodularis. ( 26277226 )
2015
36
Biopsychosocial Factors Associated with Prurigo Nodularis in Endogenous Eczema. ( 26538749 )
2015
37
The pathogenesis of Prurigo nodularis - 'Super-Itch' in exploration. ( 26416433 )
2015
38
Prurigo nodularis after acupuncture. ( 27051775 )
2015
39
Dermoscopy of prurigo nodularis. ( 25808786 )
2015
40
Oral tacrolimus treatment of pruritus in prurigo nodularis. ( 25804254 )
2015
41
Pemphigoid nodularis mimicking nodular prurigo in an immune-suppressed patient with rheumatoid arthritis. ( 24909759 )
2015
42
Persistent prurigo nodularis in HIV-infected patient responsive to antiretroviral therapy with raltegravir. ( 24479440 )
2014
43
Paraphenylenediamine dye allergic contact dermatitis of mustache region manifesting as prurigo nodularis-like lesions. ( 24603506 )
2014
44
Prurigo nodularis in a peritoneal dialysis patient. ( 24380918 )
2014
45
Intractable prurigo nodularis successfully treated with combination therapy with a newly developed excimer laser and topical steroids. ( 24945654 )
2014
46
Prurigo nodularis: retrospective study of 13 cases managed with methotrexate. ( 24825138 )
2014
47
Prurigo nodularis as index symptom of (non-Hodgkin) lymphoma: ultrasound as a helpful diagnostic tool in dermatological disorders of unknown origin. ( 24697249 )
2014
48
Prurigo nodularis and Hashimoto thyroiditis. ( 25446192 )
2014
49
Extensive prurigo nodularis: characterization and etiology. ( 24662043 )
2014
50
Oral ketotifen and topical antibiotic therapy in the management of pruritus in prurigo nodularis: a randomized, controlled, single-blind, parallel study. ( 24082179 )
2013
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Variations for Prurigo Nodularis

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Expression for Prurigo Nodularis

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Search GEO for disease gene expression data for Prurigo Nodularis.
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Pathways for Prurigo Nodularis

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Pathways related to Prurigo Nodularis according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Phospholipase-C Pathway 64
Show member pathways
 12.55 NGF NGFR SEMA3A
2
p70S6K Signaling 64
Show member pathways
 12.52 NGF NGFR SEMA3A
3
NF-KappaB Family Pathway 64
Show member pathways
 12.12 NGF NGFR SEMA3A
4
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.74 NGF TAC1
5
NGF Pathway 64
Show member pathways
 11.69 NGF NGFR
6
Brain-Derived Neurotrophic Factor (BDNF) signaling pathway 1
11.65 NGF NGFR
7
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 11.54 NGF NGFR SEMA3A
8
Immune response IFN gamma signaling pathway 22
Show member pathways
 11.45 NGF NGFR SEMA3A
9
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway 22
Show member pathways
 11.3 NGF NGFR
10
p75(NTR)-mediated signaling 1
Show member pathways
 11.22 NGF NGFR
11
Neurotrophic factor-mediated Trk receptor signaling 1
Show member pathways
 11.15 NGF NGFR
12
Guidance Cues and Growth Cone Motility 64
10.87 NGF NGFR SEMA3A
13
14-3-3 and Regulation of BAD Activity 64
10.46 NGF NGFR
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GO Terms for Prurigo Nodularis

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Cellular components related to Prurigo Nodularis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.46 NGF RNASE3 SEMA3A TAC1
2 axon GO:0030424 9.13 NGF SEMA3A TAC1
3 extracellular region GO:0005576 9.02 NGF NGFR RNASE3 SEMA3A TAC1

Biological processes related to Prurigo Nodularis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.4 NGF NGFR
2 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 9.37 NGF NGFR
3 negative regulation of neuron projection development GO:0010977 9.32 NGFR SEMA3A
4 positive regulation of axonogenesis GO:0050772 9.26 NGF NGFR
5 neurotrophin TRK receptor signaling pathway GO:0048011 9.16 NGF NGFR
6 nerve development GO:0021675 8.96 NGF SEMA3A
7 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 8.62 NGF NGFR
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Sources for Prurigo Nodularis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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