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PUPPP
MCID: PRR031
MIFTS: 25

Pruritic Urticarial Papules and Plaques of Pregnancy (PUPPP)

Categories: Genetic diseases, Immune diseases, Rare diseases, Reproductive diseases, Skin diseases
Tissues Related diseases Publications Symptoms & Phenotypes
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Aliases & Classifications for Pruritic Urticarial Papules and Plaques of Pregnancy

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MalaCards integrated aliases for Pruritic Urticarial Papules and Plaques of Pregnancy:

Name: Pruritic Urticarial Papules and Plaques of Pregnancy 56 58
Polymorphic Eruption of Pregnancy 56 52 58
Puppp 56 52 58
Pruritic Urticarial Papules Plaques of Pregnancy 52 71
Pruritic Urticarial Papules and Plaques of Pregnancy, Familial 52

Characteristics:

OMIM:

56
Inheritance:
autosomal dominant


HPO:

31
pruritic urticarial papules and plaques of pregnancy:
Inheritance autosomal dominant inheritance


Classifications:

MalaCards categories:
Global: Rare diseases Genetic diseases
Anatomical: Reproductive diseases Skin diseases Immune diseases
See all MalaCards categories (disease lists)
ICD10: 33
Orphanet: 58  
Rare gynaecological and obstetric diseases
Rare skin diseases
Rare allergic disease


External Ids:

OMIM 56 178995
MESH via Orphanet 44 C535817
ICD10 via Orphanet 33 O26.8
UMLS via Orphanet 72 C0269680
Orphanet 58 ORPHA64745
MedGen 41 C0269680
UMLS 71 C0269680
Sources

Summaries for Pruritic Urticarial Papules and Plaques of Pregnancy

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NIH Rare Diseases : 52 The following summary is from Orphanet , a European reference portal for information on rare diseases and orphan drugs. Orpha Number: 64745 Definition A rare skin disease characterized by urticarial papules and plaques with severe pruritus mainly on the abdomen, buttocks, and proximal thighs. The condition usually develops during the third trimester of the first pregnancy, although presentation in the postpartum period, which may also feature other types of skin lesions, has been described in some cases. The symptoms generally resolve within few weeks. Visit the Orphanet disease page for more resources.

MalaCards based summary : Pruritic Urticarial Papules and Plaques of Pregnancy, also known as polymorphic eruption of pregnancy, is related to pemphigoid gestationis and exanthem, and has symptoms including pruritus Affiliated tissues include skin, whole blood and placenta, and related phenotype is striae distensae.

Wikipedia : 74 Pruritic urticarial papules and plaques of pregnancy (PUPPP), known in United Kingdom as polymorphic... more...

More information from OMIM: 178995
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Related Diseases for Pruritic Urticarial Papules and Plaques of Pregnancy

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Diseases related to Pruritic Urticarial Papules and Plaques of Pregnancy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 27)
# Related Disease Score Top Affiliating Genes
1 pemphigoid gestationis 10.7
2 exanthem 10.7
3 pemphigus gestationis 10.5
4 bullous pemphigoid 10.5
5 erythema multiforme 10.3
6 intrahepatic cholestasis of pregnancy 10.3
7 pre-eclampsia 10.3
8 epidural abscess 10.3
9 oligohydramnios 10.3
10 severe pre-eclampsia 10.3
11 cholestasis 10.3
12 eclampsia 10.3
13 urticaria 10.3
14 acute kidney failure 10.1
15 purpura 10.1
16 placental abruption 10.1
17 skin disease 10.1
18 factor viii deficiency 9.8
19 vasculitis, lymphocytic, nodular 9.8
20 hemophilia a 9.8
21 dermatitis, atopic 9.8
22 hepatitis b 9.8
23 dermatitis 9.8
24 vasculitis 9.8
25 hemophilia 9.8
26 acquired hemophilia 9.8
27 acquired hemophilia a 9.8

Graphical network of the top 20 diseases related to Pruritic Urticarial Papules and Plaques of Pregnancy:



Diseases related to Pruritic Urticarial Papules and Plaques of Pregnancy
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Symptoms & Phenotypes for Pruritic Urticarial Papules and Plaques of Pregnancy

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Human phenotypes related to Pruritic Urticarial Papules and Plaques of Pregnancy:

31
# Description HPO Frequency HPO Source Accession
1 striae distensae 31 HP:0001065

Symptoms via clinical synopsis from OMIM:

56
Skin:
pruritic urticarial papules and plaques

Misc:
onset late in pregnancy
appears first in abdominal striae

Clinical features from OMIM:

178995

UMLS symptoms related to Pruritic Urticarial Papules and Plaques of Pregnancy:


pruritus
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Drugs & Therapeutics for Pruritic Urticarial Papules and Plaques of Pregnancy

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Search Clinical Trials , NIH Clinical Center for Pruritic Urticarial Papules and Plaques of Pregnancy

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Genetic Tests for Pruritic Urticarial Papules and Plaques of Pregnancy

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Anatomical Context for Pruritic Urticarial Papules and Plaques of Pregnancy

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MalaCards organs/tissues related to Pruritic Urticarial Papules and Plaques of Pregnancy:

40
Skin, Whole Blood, Placenta, Kidney
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Publications for Pruritic Urticarial Papules and Plaques of Pregnancy

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Articles related to Pruritic Urticarial Papules and Plaques of Pregnancy:

(show top 50) (show all 96)
# Title Authors PMID Year
1
Familial occurrence of pruritic urticarial papules and plaques of pregnancy. 61 56
1583169 1992
2
Postpartum pruritic urticarial papules and plaques of pregnancy with blister formation resembling herpes gestationis. 61
31903969 2019
3
A clinical study of cutaneous changes in pregnancy. 61
27870929 2017
4
Pruritic Urticarial Papules and Plaques of Pregnancy Occurring Postpartum Treated with Intramuscular Injection of Autologous Whole Blood. 61
28559815 2017
5
Pruritic folliculitis of pregnancy. 61
28300898 2016
6
Polymorphic eruption of pregnancy. 61
27265077 2016
7
Photoletter to the editor: Dermoscopy as a diagnostic aid for pruritic folliculitis of pregnancy. 61
27119004 2016
8
Pruritic urticarial papules and plaques of pregnancy occurring postpartum. 61
26125211 2015
9
Anaplastic Large Cell Lymphoma in Pregnancy. A Case Report. 61
26126315 2015
10
Three cases of pruritic urticarial papules and plaques of pregnancy (PUPPP) treated with intramuscular injection of autologous whole blood. 61
24593765 2015
11
Pruritus in pregnancy: treatment of dermatoses unique to pregnancy. 61
24336540 2013
12
The utility of C4d immunohistochemistry on formalin-fixed paraffin-embedded tissue in the distinction of polymorphic eruption of pregnancy from pemphigoid gestationis. 61
24061402 2013
13
Pruritic urticarial papules and plaques of pregnancy with unique distribution developing in postpartum period. 61
24371406 2013
14
Specific dermatoses of pregnancy and their treatment. 61
23914884 2013
15
Pruritic urticarial papules and plaques of pregnancy: epidemiological, clinical, and histopathological study of 18 cases from Lebanon. 61
22909357 2012
16
Pruritic urticarial papules and plaques of pregnancy. 61
22369410 2012
17
Recalcitrant pruritic urticarial papules and plaques of pregnancy with a prolonged course after delivery. 61
22155185 2012
18
Polymorphic eruption of pregnancy developing postpartum: 2 case reports. 61
25386317 2012
19
Dermatoses of pregnancy - clues to diagnosis, fetal risk and therapy. 61
21909194 2011
20
Pemphigoid gestationis. 61
21163161 2010
21
Pruritic urticarial papules and plaques of pregnancy wholly abated with one week twice daily application of fluticasone propionate lotion: a case report and review of the literature. 61
19094842 2008
22
[Pruritic urticarial papules and plaques of pregnancy]. 61
19227781 2008
23
An update on the dermatoses of pregnancy. 61
18390233 2008
24
A clinical study of skin changes in pregnancy. 61
17458033 2007
25
Pruritic urticarial papules and plaques of pregnancy. 61
17207750 2007
26
Common skin conditions during pregnancy. 61
17263216 2007
27
Case report: epidural abscess in a parturient with pruritic urticarial papules and plaques of pregnancy (PUPPP). 61
16987856 2006
28
[Specific dermatoses of pregnancy]. 61
16886690 2006
29
Pregnancy outcome of patients with pruritic urticarial papules and plaques of pregnancy. 61
16753771 2006
30
Pruritic urticarial papules and plaques of pregnancy: polymorphic eruption of pregnancy (PUPPP). 61
16487883 2006
31
Polymorphic eruption of pregnancy: clinicopathology and potential trigger factors in 181 patients. 61
16403094 2006
32
Usefulness of BP180 NC16a enzyme-linked immunosorbent assay in the serodiagnosis of pemphigoid gestationis and in differentiating between pemphigoid gestationis and pruritic urticarial papules and plaques of pregnancy. 61
15967916 2005
33
[Dermatoses specific for pregnancy period]. 61
16145862 2005
34
Pruritic urticarial papules and plaques of pregnancy with unusual and extensive palmoplantar involvement. 61
15863603 2005
35
Pruritic urticarial papules and plaques of pregnancy: current status. 61
15842394 2005
36
Pruritic urticarial papules and plaques of pregnancy presenting in the postpartum period: a case report. 61
15730177 2005
37
[Pruritus in pregnancy. A frequent diagnostic and therapeutic challenge]. 61
15536515 2005
38
[Is there an association between PUPPP and preeclampsia, abruptio placentae and fetal death?]. 61
15666703 2004
39
A case of pruritic urticarial papules and plaques of pregnancy associated with external cephalic version. 61
15628327 2004
40
The role of T lymphocytes and cytokines in the pathogenesis of pemphigoid gestationis. 61
12828741 2003
41
Pruritic urticarial papules and plaques of pregnancy (PUPPP)--a case report. 61
12891469 2003
42
[What is your diagnosis? Pruritic urticarial papules and plaques of pregnancy]. 61
12793119 2003
43
Specific dermatoses of pregnancy: an evidence-based systematic review. 61
12712115 2003
44
Pruritic urticarial papules and plaques of pregnancy: an unusual case. 61
11837341 2002
45
Focus on primary care: pruritic dermatological conditions in pregnancy. 61
11435950 2001
46
[Pruritic urticaria-related papules and plaques of pregnancy: a case report]. 61
11526750 2001
47
Expression of progesterone receptor in human keratinocytes. 61
11194191 2000
48
Pruritic urticarial papules and plaques of pregnancy and multiple pregnancies. 61
11004645 2000
49
Pruritic urticarial papules and plaques of pregnancy in twin and triplet pregnancies. 61
11305379 2000
50
Pruritic urticarial papules and plaques of pregnancy: clinical and immunopathologic observations in 57 patients. 61
9843004 1998
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Variations for Pruritic Urticarial Papules and Plaques of Pregnancy

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Expression for Pruritic Urticarial Papules and Plaques of Pregnancy

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Search GEO for disease gene expression data for Pruritic Urticarial Papules and Plaques of Pregnancy.
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Pathways for Pruritic Urticarial Papules and Plaques of Pregnancy

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GO Terms for Pruritic Urticarial Papules and Plaques of Pregnancy

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Sources for Pruritic Urticarial Papules and Plaques of Pregnancy

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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