MCID: PSD086
MIFTS: 30

Pseudoarthrosis

Categories: Rare diseases

Aliases & Classifications for Pseudoarthrosis

MalaCards integrated aliases for Pseudoarthrosis:

Name: Pseudoarthrosis 38
Pseudarthrosis 73

Classifications:



External Ids:

UMLS 73 C0033785

Summaries for Pseudoarthrosis

MalaCards based summary : Pseudoarthrosis, also known as pseudarthrosis, is related to congenital pseudoarthrosis and congenital pseudoarthrosis of the tibia. An important gene associated with Pseudoarthrosis is NF1 (Neurofibromin 1). The drugs Anesthetics and Cimetidine have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and testes, and related phenotypes are craniofacial and limbs/digits/tail

Related Diseases for Pseudoarthrosis

Diseases in the Pseudoarthrosis family:

Congenital Pseudoarthrosis

Diseases related to Pseudoarthrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 congenital pseudoarthrosis 12.0
2 congenital pseudoarthrosis of the tibia 12.0
3 congenital pseudoarthrosis of the fibula 12.0
4 congenital pseudoarthrosis of the radius 12.0
5 congenital pseudoarthrosis of the ulna 12.0
6 congenital pseudoarthrosis of the femur 12.0
7 congenital pseudoarthrosis of the limbs 11.8
8 osteofibrous dysplasia 11.3
9 clavicle, pseudarthrosis of, congenital 11.2
10 cervicitis 10.0
11 hyperostosis 10.0
12 diffuse idiopathic skeletal hyperostosis 10.0
13 amniotic band syndrome 9.9
14 neurofibromatosis, type i 9.8
15 osteoporosis 9.8
16 spondylolisthesis 9.8
17 arthritis 9.8
18 osteomalacia 9.8
19 thoracic outlet syndrome 9.8
20 spondylitis 9.8
21 osteochondroma 9.8
22 spondyloarthropathy 1 9.7
23 carpal tunnel syndrome 9.7
24 cervical rib 9.7
25 cleft palate, isolated 9.7
26 coxa vara 9.7
27 neurofibromatosis, type iv, of riccardi 9.7
28 constricting bands, congenital 9.7
29 aging 9.7
30 devriendt syndrome 9.7
31 mononeuropathy of the median nerve, mild 9.7
32 diabetes mellitus 9.7
33 osteonecrosis 9.7
34 somatostatinoma 9.7
35 klippel-feil syndrome 9.7
36 primary hyperparathyroidism 9.7
37 synostosis 9.7
38 hyperparathyroidism 9.7
39 exostosis 9.7
40 ankylosis 9.7
41 duodenal somatostatinoma 9.7
42 osgood-schlatter's disease 9.7
43 duodenitis 9.7
44 type i 9.7
45 gigantism 9.7
46 venous thoracic outlet syndrome 9.7
47 multiple endocrine neoplasia, type iia 9.2 NF1 PTH
48 organ system benign neoplasm 9.0 NF1 PTH

Graphical network of the top 20 diseases related to Pseudoarthrosis:



Diseases related to Pseudoarthrosis

Symptoms & Phenotypes for Pseudoarthrosis

MGI Mouse Phenotypes related to Pseudoarthrosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 8.96 NF1 PTH
2 limbs/digits/tail MP:0005371 8.62 NF1 PTH

Drugs & Therapeutics for Pseudoarthrosis

Drugs for Pseudoarthrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anesthetics Phase 2
2
Cimetidine Approved, Investigational Not Applicable 51481-61-9 2756
3
Meloxicam Approved, Vet_approved Not Applicable 71125-38-7 5281106 54677470
4
s 1 (combination)
5 Anti-Bacterial Agents
6 Anti-Infective Agents
7 Gentamicins
8 Analgesics Not Applicable
9 Analgesics, Non-Narcotic Not Applicable
10 Anti-Inflammatory Agents Not Applicable
11 Anti-Inflammatory Agents, Non-Steroidal Not Applicable
12 Antirheumatic Agents Not Applicable
13 Cyclooxygenase Inhibitors Not Applicable
14 Peripheral Nervous System Agents Not Applicable

Interventional clinical trials:

(show top 50) (show all 57)
# Name Status NCT ID Phase Drugs
1 BIO4 Clinical Case Study: Cervical Spine Recruiting NCT03077204 Phase 4
2 Surgical Treatment of Spinal Deformity With Sagittal Imbalance Using Patient-specific Rods: A Multicenter, Controlled, Double- Blind Randomized Trial: The PROFILE Study Not yet recruiting NCT02730507 Phase 3
3 Clinical Trial Based on the Use of Mononuclear Cells From Autologous Bone Marrow in Patients With Pseudoarthrosis Completed NCT01813188 Phase 2
4 Treatment of Atrophic Nonunion by Preosteoblast Cells Completed NCT00916981 Phase 1, Phase 2
5 A Study of INFUSE Bone Graft (BMP-2) in the Treatment of Tibial Pseudarthrosis in Neurofibromatosis Type 1 (NF1) Recruiting NCT02718131 Phase 2
6 A Clinical Trial to Assess the Effect of HC-SVT-1001 in the Surgical Treatment of Atrophic Pseudarthrosis of Long Bones Recruiting NCT02483364 Phase 2
7 Mesenchymal Stromal Cells for the Treatment of Non-union Fractures of Long Bones Active, not recruiting NCT02230514 Phase 1, Phase 2 XCEL-MT-OSTEO-ALPHA
8 Phase 2a Study on Allogeneic Osteoblastic Cells Implantation in Lumbar Spinal Fusion Active, not recruiting NCT02205138 Phase 2 ALLOB® cells with ceramic scaffold
9 Study on Allogeneic Osteoblastic Cells Implantation in Rescue Interbody Fusion Active, not recruiting NCT02328287 Phase 2 ALLOB®
10 Osseous Setting Improvement With Co-implantation of Osseous Matrix and Mesenchymal Progenitors Cells From Autologous Bone Marrow Suspended NCT00557635 Phase 2
11 Feasibility Study of Aastrom Tissue Repair Cells to Treat Non-Union Fractures. Terminated NCT00424567 Phase 1, Phase 2 Cultured Bone Marrow Tissue
12 Clinical Trial of Use of Autologous Bone Marrow Stem Cells Seeded on Porous Tricalcium Phosphate Matrix and Demineralized Bone Matrix in Patients With Osteonecrosis Recruiting NCT02566681 Phase 1
13 Dynesys Spinal System Post Market 522 Study Unknown status NCT01528072 Not Applicable
14 rhBMP-2 vs Autologous Bone Grafting for the Treatment of Non-union of the Docking Site in Tibial Bone Transport Unknown status NCT01756144 Not Applicable
15 Radiostereometric Analysis of Spine Arthrodesis Unknown status NCT01721889
16 Humeral Shaft Pseudoarthrosis Treated With Bone Autograft Versus Platelet Rich Plasma Completed NCT02520089 Not Applicable
17 Segment Transport Versus Acute Shortening In The Treatment of Tibial Pseudarthroses With Bone Loss Completed NCT01246934 Not Applicable
18 Validation of Laboratory Test for Predicting Bone Tissue Regeneration Completed NCT01362413
19 A Study Comparing Fusion Rates of Two Lumbar Fusion Procedures Completed NCT01972256
20 The Effect of Extracorporeal Shock Wave Therapy on Carpal Tunnel Syndrome Completed NCT02218229 Not Applicable
21 Modification of ESIN-osteosynthesis in a Femoral Fracture Model and Its Transmission to Clinical Practice Completed NCT01673048 Not Applicable
22 A Postmarket Surveillance Study of the Paradigm Spine Dynamic Stabilization System (DSS) Completed NCT01461005 Not Applicable
23 Evaluation of Handling and Possible Complications Related to the Newly Developed Angular Stable Locking System (ASLS) Completed NCT00793637
24 INDEPENDENCE Spacer for Lumbar Fusion Completed NCT02299323
25 Patient Outcomes Evaluation of the EBI Vuelock™ Anterior Cervical Plate System Completed NCT00726128
26 Supplemental Anterior Lumbar Interbody Fusion (ALIF) in Spinal Deformity Completed NCT01601054 Not Applicable
27 Surgical Treatment for Degenerative Scoliosis Completed NCT01439906
28 High Tibial Osteotomy for Osteoarthritis of the Knee Completed NCT01977261 Not Applicable
29 Posterior Lateral Fusion (PLF) With Dynesys Completed NCT00791180
30 Single Versus Double Kirschner Wires for Intramedullary Fixation of Metacarpal V Fractures Completed NCT01803789 Not Applicable
31 Clinical Follow-up to Evaluate the Clinical Usefulness of Gentamicin-coated Titanium Nails in Tibia Fractures Completed NCT01282294
32 Sagittal Plane Correction With Pass-LP Device in Adult Deformity Patients Completed NCT01635322
33 The Effect of Combined Surgery in Management of Congenital Pseudarthrosis of Tibia Recruiting NCT02640040 Not Applicable
34 A Retrospective Study of Surgical Treatment of Congenital Pseudarthrosis of Tibia in China Recruiting NCT02896114
35 The Effect of Percutaneous Kirschner Wire Technique in Management of CPT Under One Year Old Recruiting NCT03257826 Not Applicable
36 Musculoskeletal Non-tumoral Pathology Quantitative Perfusion Recruiting NCT02683252 Not Applicable
37 Bone Microcirculation After Remote Ischemic Preconditioning Recruiting NCT02554500 Not Applicable
38 Bone Microcirculation After Extracorporeal Shock Wave Therapy Recruiting NCT02424084 Not Applicable
39 Influence of Laminoplasty and Internal Fixation on Vertebral Stability After Laminectomy Recruiting NCT02436863
40 Plate Fixation Versus Intramedullary Nailing of 3 and 4 Part Proximal Humerus Fractures Recruiting NCT02944058 Not Applicable
41 MIS ReFRESH: Robotic vs. Freehand Minimally Invasive Spinal Surgeries Recruiting NCT02057744
42 Patient Specific Template Guided Pedicle Instrumentation Versus Free Hand Technique Recruiting NCT03318692 Not Applicable
43 Facet Wedge Post Market Study Active, not recruiting NCT02203448
44 Post-market Surveillance Study With the HYPERION Hip Endoprosthesis System in Defect Reconstruction Active, not recruiting NCT03382665
45 Collecting Bone Graft During Spinal Decompression and Posterolateral Lumbar Fusion to Better Define Bone Making Cells Enrolling by invitation NCT01409954
46 Stand-Alone Cage Verus Anterior Plating for Anterior Cervical Discectomy and Fusion. Enrolling by invitation NCT03312192 Not Applicable
47 Comparison of Complication Rates Between Lateral Approaches to the Lumbar Spine Enrolling by invitation NCT02068729
48 Occipito-Cervical Stabilization Using Occipital Condyle Screw Not yet recruiting NCT03250611 Not Applicable
49 CORset Versus OstéoSynthese in Adult Pyogenic Spondylodiscitis Not yet recruiting NCT03524209 Not Applicable
50 Vertebral Column Resection (VCR) in Congenital Kyphoscoliosis (CKS) Not yet recruiting NCT03524027 Not Applicable

Search NIH Clinical Center for Pseudoarthrosis

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Pseudoarthrosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Pseudoarthrosis:
Bone marrow-derived mesenchymal stem cells for treatment of pseudoarthrosis
PREOB
Embryonic/Adult Cultured Cells Related to Pseudoarthrosis:
Bone marrow-derived mesenchymal stem cells (family)

Genetic Tests for Pseudoarthrosis

Anatomical Context for Pseudoarthrosis

MalaCards organs/tissues related to Pseudoarthrosis:

41
Bone, Bone Marrow, Testes

Publications for Pseudoarthrosis

Articles related to Pseudoarthrosis:

(show top 50) (show all 106)
# Title Authors Year
1
Salvage Anterior Lumbar Interbody Fusion for Pseudoarthrosis After Posterior or Transforaminal Lumbar Interbody Fusion: A Review of 10 Patients. ( 29309972 )
2018
2
Preventing Pseudoarthrosis and Proximal Junctional Kyphosis: How to Deal with the Osteoporotic Spine. ( 29933804 )
2018
3
Anterolateral Bowing of Congenital Pseudoarthrosis of Tibia Treated by Percutaneous Osteotomy and Gradual Correction Using Taylor Spatial Frame, then Late Insertion of a Fussier-Duval Nail: A Case Report. ( 29636441 )
2018
4
A Cohort Study of the Natural History of Odontoid Pseudoarthrosis Managed Nonoperatively in Elderly Patients. ( 29597016 )
2018
5
Retraction Notice to: Amniotic Band Syndrome with Pseudoarthrosis of Tibia and Fibula: A Case Report [J Foot Ankle Surg. 56 (2017) 1121-1124]. ( 29478484 )
2018
6
Amniotic band syndrome with pseudoarthrosis of tibia and fibula: A case report. ( 28737311 )
2017
7
Management of Coxa Vara Septica and Pseudoarthrosis of the Femoral Neck: A Case Report. ( 28434011 )
2017
8
Amniotic Band Syndrome With Pseudoarthrosis of Tibia and Fibula: A Case Report. ( 28623060 )
2017
9
Congenital Pseudoarthrosis of the Distal Radius Treated With Physeal-Sparing Double-Barrel Vascularized Free Fibula Transfer: A Case Report. ( 28403653 )
2017
10
Femoral neck pseudoarthrosis in a polio patient treated with closed reduction and cell therapy. ( 29644312 )
2017
11
Pedicled Sensate Composite Calcaneal Flap in Children With Congenital Tibial Pseudoarthrosis. ( 28195886 )
2017
12
A Capsular-based Vascularized Distal Radius Graft in Treatment of Proximal Pole Scaphoid Pseudoarthrosis. Case Study. ( 28155839 )
2016
13
Re: Rubino M, Cavagnaro L and Sansone V. A new surgical technique for the treatment of scaphotrapezial arthritis associated with trapeziometacarpal arthritis: the narrow pseudoarthrosis. J Hand Surg Eur. 2016, 41: 710-718. ( 27539832 )
2016
14
Pseudoarthrosis of the Ulna in Neurofibromatosis Type I. ( 27453377 )
2016
15
Clinical translation of a Mesenchymal Stromal Cell-based therapy developed in a large animal model and two case studies of the treatment of atrophic pseudoarthrosis. ( 27684058 )
2016
16
Percutaneous Transpedicular Interbody Fusion Technique in Percutaneous Pedicle Screw Stabilization for Pseudoarthrosis Following Pyogenic Spondylitis. ( 27114777 )
2016
17
Pseudoarthrosis of the ilium after periacetabular osteotomy that was treated by cemented total hip arthroplasty: a case report. ( 27150356 )
2016
18
Bilateral congenital pseudoarthrosis of the clavicles in a newborn. ( 27695169 )
2016
19
rhBMP-2 protects against reoperation for pseudoarthrosis and/or instrumentation failure: A matched case-control study of 448 patients. ( 27396376 )
2016
20
An alternative treatment method for defective pseudoarthrosis; evaluation of eight patients treated with Artelon+Kryptonite. ( 26984665 )
2016
21
Troubleshooting in the Treatment of Pseudoarthrosis After a Humeral Diaphyseal Fracture: A Case Report. ( 27980312 )
2016
22
Human pseudoarthrosis tissue contains cells with osteogenic potential. ( 27025566 )
2016
23
Pseudoarthrosis Repair Using Autologous Cultured Osteoblasts in Complex Type-1 Neurofibromatosis Spinal Deformity. A Case Report and Review of the Literature. ( 27145468 )
2016
24
Percutaneous Pedicle Screw Fixation with Polymethylmethacrylate Augmentation for the Treatment of Thoracolumbar Intravertebral Pseudoarthrosis Associated with Kummell's Osteonecrosis. ( 27595101 )
2016
25
Durotomy is associated with pseudoarthrosis following lumbar fusion. ( 25532509 )
2015
26
A new surgical technique for the treatment of scaphotrapezial arthritis associated with trapeziometacarpal arthritis: the narrow pseudoarthrosis. ( 26453601 )
2015
27
Posterolateral lumbar fusion: Relationship between computed tomography Hounsfield units and symptomatic pseudoarthrosis. ( 26693390 )
2015
28
Pseudoarthrosis rates in anterior cervical discectomy and fusion: a meta-analysis. ( 25982430 )
2015
29
Congenital pseudoarthrosis in a child with neurofibromatosis. ( 26670897 )
2015
30
Isolation and Characterization of Multipotential Mesenchymal Stromal Cells from Congenital Pseudoarthrosis of the Tibia: Case Report. ( 26194170 )
2015
31
Effectiveness of recombinant human bone morphogenetic protein-7 in the management of congenital pseudoarthrosis of the tibia: a randomised controlled trial. ( 24827969 )
2014
32
Congenital Pseudoarthrosis of Medial Malleolus in A Young Soccer Player - Diagnosis in Clinical setting of Ankle Sprain. ( 27298936 )
2014
33
Usefulness of an early MRI-based classification system for predicting vertebral collapse and pseudoarthrosis after osteoporotic vertebral fractures. ( 24201154 )
2014
34
Congenital pseudoarthrosis of clavicula. ( 26078674 )
2014
35
Combined use of Ilizarov external fixation and Papineau technique for septic pseudoarthrosis of the distal tibia in a patient with diabetes mellitus. ( 24563728 )
2014
36
Treatment of pseudoarthrosis after minimally invasive hallux valgus correction. ( 25013553 )
2014
37
Cost per Quality Adjusted Life Year Gained of Revision Fusion for Lumbar Pseudoarthrosis: Defining the Value of Surgery. ( 24999554 )
2014
38
Sarcomatous transformation of osteochondroma of the coronoid process forming pseudoarthrosis with zygomatic arch mistaken for Jacob disease. ( 24448526 )
2014
39
Neurofibromin Deficiency-Associated Transcriptional Dysregulation Suggests a Novel Therapy for Tibial Pseudoarthrosis in NF1. ( 24932921 )
2014
40
Congenital pseudoarthrosis of the clavicle with bifurcation. ( 25143653 )
2014
41
Congenital Pseudoarthrosis of the Clavicle: A Diagnostic Challenge. ( 27335927 )
2014
42
Posterior instrumentation and simultaneous intertransverse approach using transforaminal cage fusion for thoracic pseudoarthrosis in ankylosing spondylitis: a case report. ( 23765917 )
2013
43
Pseudoarthrosis and fracture: interaction between severe vitamin D deficiency and primary hyperparathyroidism. ( 24276109 )
2013
44
Congenital metacarpal pseudoarthrosis, cleft palate, short stature, advanced bone age, and genu valgum: a new syndrome or a variant of Devriendt syndrome? ( 23448907 )
2013
45
Congenital pseudoarthrosis tibia with fibrous hamartoma in a child with neurofibromatosis. ( 24014976 )
2013
46
An unconventional indication of the Sauve' - Kapandji procedure in a radial shaft pseudoarthrosis and chronic DRUJ dislocation: a case report. ( 23698215 )
2013
47
Treatment of pseudoarthrosis of the upper limb using expanded mesenchymal stem cells: a pilot study. ( 23377812 )
2013
48
Pseudoarthrosis in atypical femoral fracture: case report. ( 23681089 )
2013
49
Pseudoarthrosis of medial tibial plateau fracture----role of alignment procedure. ( 23540903 )
2013
50
Repair of long-bone pseudoarthrosis with autologous bone marrow mononuclear cells combined with allogenic bone graft. ( 23415918 )
2013

Variations for Pseudoarthrosis

Expression for Pseudoarthrosis

Search GEO for disease gene expression data for Pseudoarthrosis.

Pathways for Pseudoarthrosis

GO Terms for Pseudoarthrosis

Biological processes related to Pseudoarthrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of gene expression GO:0010468 8.62 NF1 PTH

Sources for Pseudoarthrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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