PBA
MCID: PSD088
MIFTS: 33

Pseudobulbar Affect (PBA)

Categories: Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Pseudobulbar Affect

MalaCards integrated aliases for Pseudobulbar Affect:

Name: Pseudobulbar Affect 20
Emotional Lability 20 29 6
Involuntary Emotional Expression Disorder 20 70
Pathological Crying and Laughing 20
Emotional Incontinence 20
Mood Swings 70
Pba 20

Classifications:



External Ids:

UMLS 70 C0085633 C3161187

Summaries for Pseudobulbar Affect

GARD : 20 Pseudobulbar affect (PBA) is a condition characterized by episodes of sudden, uncontrollable and inappropriate episodes of crying or laughing. The condition can be embarrassing and disruptive to daily life. It typically occurs in people with certain neurological conditions or injuries that affect the way the brain controls emotion. It is common in stroke survivors and people with conditions such as dementia, multiple sclerosis, Lou Gehrig's disease (ALS) and traumatic brain injury. PBA is thought to affect more than one million people in the United States. The goal of treatment is to reduce the severity and frequency of emotional outbursts. Treatment may include the use of antidepressants and/or a combination of dextromethorphan and quinidine.

MalaCards based summary : Pseudobulbar Affect, also known as emotional lability, is related to progressive bulbar palsy and kuru, and has symptoms including mental and behavioral signs and symptoms, nervousness and demoralization and apathy. An important gene associated with Pseudobulbar Affect is CYP2D6 (Cytochrome P450 Family 2 Subfamily D Member 6). The drugs Citalopram and Rivastigmine have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and cortex.

Wikipedia : 73 Pseudobulbar affect (PBA), or emotional incontinence, is a type of emotional disturbance characterized... more...

Related Diseases for Pseudobulbar Affect

Diseases related to Pseudobulbar Affect via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Related Disease Score Top Affiliating Genes
1 progressive bulbar palsy 11.1
2 kuru 11.1
3 colloid cysts of third ventricle 11.1
4 x-linked cerebral adrenoleukodystrophy 11.1
5 chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids 11.0
6 amyotrophic lateral sclerosis 1 10.7
7 lateral sclerosis 10.7
8 attention deficit-hyperactivity disorder 10.6
9 traumatic brain injury 10.5
10 brain injury 10.4
11 oppositional defiant disorder 10.3
12 dementia 10.3
13 mood disorder 10.3
14 multiple sclerosis 10.3
15 stroke, ischemic 10.2
16 parkinson disease, late-onset 10.2
17 substance abuse 10.1
18 apraxia 10.1
19 endogenous depression 10.1
20 urinary tract infection 10.1
21 mental depression 10.1
22 depression 10.1
23 encephalopathy 10.1
24 huntington disease 10.1
25 glioma susceptibility 1 9.9
26 systemic lupus erythematosus 9.9
27 autism 9.9
28 anxiety 9.9
29 microphthalmia, syndromic 10 9.9
30 autism spectrum disorder 9.9
31 borderline personality disorder 9.9
32 pseudobulbar palsy 9.9
33 quadriplegia 9.9
34 post-traumatic stress disorder 9.9
35 motor neuron disease 9.9
36 malignant astrocytoma 9.9
37 ischemia 9.9
38 neurotic disorder 9.9
39 severe combined immunodeficiency 9.9
40 lupus erythematosus 9.9
41 dementia pugilistica 9.9
42 alzheimer disease 9.9
43 cardiac arrhythmia 9.9
44 meningioma, familial 9.9
45 major depressive disorder 9.9
46 major affective disorder 8 9.9
47 major affective disorder 9 9.9
48 intracranial meningioma 9.9
49 parkinsonism 9.9
50 respiratory failure 9.9

Graphical network of the top 20 diseases related to Pseudobulbar Affect:



Diseases related to Pseudobulbar Affect

Symptoms & Phenotypes for Pseudobulbar Affect

UMLS symptoms related to Pseudobulbar Affect:


mental and behavioral signs and symptoms; nervousness; demoralization and apathy; other signs and symptoms involving emotional state; signs and symptoms involving emotional state; pregnancy mood swing

Drugs & Therapeutics for Pseudobulbar Affect

Drugs for Pseudobulbar Affect (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 68)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Citalopram Approved Phase 4 59729-33-8 2771
2
Rivastigmine Approved, Investigational Phase 4 123441-03-2 77991
3
Valproic acid Approved, Investigational Phase 4 99-66-1 3121
4
Quinidine Approved, Investigational Phase 4 56-54-2 441074
5
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
6
Dextromethorphan Approved Phase 4 125-71-3 5360696 5362449
7
Phenylpropanolamine Approved, Vet_approved, Withdrawn Phase 4 14838-15-4 26934
8
Coenzyme Q10 Approved, Investigational, Nutraceutical Phase 4 303-98-0 5281915
9
Dexetimide Withdrawn Phase 4 21888-98-2
10 Serotonin Uptake Inhibitors Phase 4
11 Antidepressive Agents Phase 4
12 Cholinesterase Inhibitors Phase 4
13 Neuroprotective Agents Phase 4
14 Protective Agents Phase 4
15 Ubiquinone Phase 4
16 Psychotropic Drugs Phase 4
17 Anticonvulsants Phase 4
18 Neurotransmitter Agents Phase 4
19 Cholinergic Agents Phase 4
20 Respiratory System Agents Phase 4
21 Sodium Channel Blockers Phase 4
22 Anti-Arrhythmia Agents Phase 4
23 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
24 Cholinergic Antagonists Phase 4
25 Diuretics, Potassium Sparing Phase 4
26 Adrenergic Antagonists Phase 4
27 Antiparasitic Agents Phase 4
28 Excitatory Amino Acid Antagonists Phase 4
29 Quinidine gluconate Phase 4
30 Adrenergic alpha-Antagonists Phase 4
31 Antiprotozoal Agents Phase 4
32 Antitussive Agents Phase 4
33 Muscarinic Antagonists Phase 4
34 Adrenergic Agents Phase 4
35 Antimalarials Phase 4
36 Anti-Infective Agents Phase 4
37 Cytochrome P-450 Enzyme Inhibitors Phase 4
38
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
39
Polyestradiol phosphate Approved 28014-46-2
40
Estradiol Approved, Investigational, Vet_approved 50-28-2 5757
41
Ethinyl Estradiol Approved 57-63-6 5991
42
Etonogestrel Approved, Investigational 54048-10-1 40976 6917715
43
Desogestrel Approved 54024-22-5 40973
44
Mestranol Approved 72-33-3 6291
45
Ferrous fumarate Approved 141-01-5
46
Norethindrone Approved 68-22-4 6230
47
Ethanol Approved 64-17-5 702
48
Dopamine Approved 51-61-6, 62-31-7 681
49
tannic acid Approved 1401-55-4
50
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 A Multicenter, Double Blind Trial to Compare the Efficacy and Safety of Escitalopram With Placebo in Patients With Acute Stroke for the Prevention of Poststroke Depression and Related Symptoms (Emotional Incontinence, Anger Proneness), and for Improvement of Neurologic, Cognitive Function and Quality of Life Unknown status NCT01278498 Phase 4 Escitalopram;sugar pill
2 Study of the Effects of Current Drug Treatments on Levels of Certain Brain Chemicals in Alzheimer's Disease Completed NCT00104442 Phase 4 Rivastigmine
3 A Study to Assess the Safety, Tolerability and Effectiveness of Nuedexta (Dextromethorphan 20 mg/Quinidine 10 mg) in the Treatment of Pseudobulbar Affect (PBA) Completed NCT01799941 Phase 4 Nuedexta (DM 20 mg/Q 10 mg)
4 Double Blind Placebo Controlled Study of Depakote (Divalproex Sodium) in Children With Temper Outbursts and Severe Mood Swings Completed NCT02078596 Phase 4 Divalproex
5 A Study to Assess Effectiveness, Safety, and Health-related Outcomes of NUEDEXTA® (Dextromethorphan Hydrobromide and Quinidine Sulfate) for the Treatment of Pseudobulbar Affect (PBA) in Nursing Home Patients Terminated NCT02496039 Phase 4 NUEDEXTA®
6 Clinical Protocol of a Prospective, Open-label Study to Assess the Safety and Efficacy of Nuedexta (Dextromethorphan/Quinidine) in the Treatment of Pseudobulbar Affect (PBA) in Patients With Alzheimer's Disease Terminated NCT01832350 Phase 4 Nuedexta (20/10)
7 A Double-Blind, Randomized, Placebo-Controlled, Multicenter Study to Assess the Safety and Efficacy and to Determine the Pharmacokinetics of Two Doses of AVP-923 (Dextromethorphan/Quinidine) in the Treatment of Pseudobulbar Affect (PBA) in Patients With Amyotrophic Lateral Sclerosis (ALS) and Multiple Sclerosis (MS) Completed NCT00573443 Phase 3 dextromethorphan hydrobromide 20 mg and quinidine sulfate 10 mg;dextromethorphan hydrobromide 30 mg and quinidine sulfate 10 mg;Placebo
8 An Open-Label Multicenter Study to Assess the Safety of AVP-923 in the Treatment of Patients With Pseudobulbar Affect. Completed NCT00056524 Phase 3 AVP-923
9 A Double-Blind Controlled, Multicenter Phase II/III Study to Assess the Safety and Efficacy of AVP-923 (Dextromethorphan/Quinidine) in the Treatment of Pseudobulbar Affect in Patients With Amyotrophic Lateral Sclerosis Completed NCT00021697 Phase 3 AVP-923
10 Safety and Efficacy of AVP-923 for Pseudobulbar Affect in Multiple Sclerosis Patients Completed NCT00050232 Phase 3 AVP-923
11 Double-Blind, Placebo-Controlled Study of Depakote (Divalproex Sodium) in Children With Temper Outbursts and Severe Mood Swings Completed NCT00217932 Phase 2 Divalproex Sodium (Depakote)
12 PRISM Registry: Pseudobulbar Affect Registry Series Completed NCT01366027
13 The Frequency and Management of Breakthrough Bleeding During Extended Therapy With the Transvaginal Contraceptive Ring Completed NCT00475553
14 Prospective Comparison of Hormone Withdrawal Symptoms of a 24/4 Regimen With a 21/7 Regimen of OC Completed NCT00475189 loestrin 24/4 vs loestrin 1/20;loestrin 1/20
15 The Effect of Moderate Alcohol Consumption With a Meal in Different Ambiances on Postprandial Mood, Evaluated by Subjective and Physiological Responses Completed NCT01426022
16 Yoga Based Psychotherapy Group Feasibility and Efficacy Study Completed NCT01524172 Early Phase 1
17 Examining the Effects of Stimulant Medication on Emotional Lability in Patients With Attention Deficit Hyperactivity Disorder (ADHD) Completed NCT01415440 Lisdexamfetamine;Placebo
18 Cognitive-Behavior Therapy for Bipolar Disorder Completed NCT00595387

Search NIH Clinical Center for Pseudobulbar Affect

Genetic Tests for Pseudobulbar Affect

Genetic tests related to Pseudobulbar Affect:

# Genetic test Affiliating Genes
1 Emotional Lability 29

Anatomical Context for Pseudobulbar Affect

MalaCards organs/tissues related to Pseudobulbar Affect:

40
Brain, Temporal Lobe, Cortex, Amygdala, Hypothalamus, Spinal Cord, Bone

Publications for Pseudobulbar Affect

Articles related to Pseudobulbar Affect:

(show top 50) (show all 940)
# Title Authors PMID Year
1
Features of Menstruation and Menstruation Management in Individuals with Rett Syndrome. 61
33186698 2021
2
Psychiatric Basics of Alopecia Areata in Pediatric Patients: Evaluation of Emotion Dysregulation, Somatization, Depression and Anxiety Levels. 61
33797195 2021
3
Alternative DSM-5 Model for Personality Disorders Through the Lens of an Empirical Network Model. 61
31928067 2021
4
Excessive screen time is associated with emotional lability in preschool children. 61
33749196 2021
5
"The Heidelberg Five" personality dimensions: Genome-wide associations, polygenic risk for neuroticism, and psychopathology 20 years after assessment. 61
33590662 2021
6
The relationship of emotion regulation and negative lability with socioemotional adjustment in institutionalized and non-institutionalized children. 61
33108007 2021
7
Neuropsychiatric symptoms associated with cerebral small vessel disease: a systematic review and meta-analysis. 61
33539776 2021
8
Association of Wender Utah Rating Scale (WURS)-61 items with clinical psychiatric diagnosis in adulthood. 61
33665779 2021
9
Comparison of Two Clinical Upper Motor Neuron Burden Rating Scales in ALS Using Quantitative Brain Imaging. 61
33576234 2021
10
Natural History of Pure Primary Lateral Sclerosis. 61
33637635 2021
11
Limbic encephalitis in a patient with systemic lupus erythematosus successfully treated with high-dose glucocorticoids and intravenous cyclophosphamide therapy: the potential pathogenicity of anti-glutamate receptor antibodies. 61
33441041 2021
12
Personality changes in patients with refractory epilepsy after surgical treatment: A systematic review. 61
33453594 2021
13
Estimating Repeat Traumatic Brain Injury in the U.S. Military, 2015-2017. 61
33591307 2021
14
A Unique Case of Valacyclovir Toxicity and Pseudobulbar Affect in a Patient On Peritoneal Dialysis. 61
33777579 2021
15
International Society for the Study of Women's Sexual Health (ISSWSH) Review of Epidemiology and Pathophysiology, and a Consensus Nomenclature and Process of Care for the Management of Persistent Genital Arousal Disorder/Genito-Pelvic Dysesthesia (PGAD/GPD). 61
33612417 2021
16
An ecological momentary assessment study of the role of emotional dysregulation in co-occurring ADHD and internalising symptoms in adulthood. 61
33234281 2021
17
Intensive care nurses' experiences during the COVID-19 pandemic: A qualitative study. 61
33401340 2021
18
Clozapine Efficacy in a Case of Severe Treatment-Resistant Postpartum Psychosis. 61
33603521 2021
19
Analysing Joker: an attempt to establish diagnosis for a film icon. 61
33407973 2021
20
Extra-motor cerebral changes and manifestations in primary lateral sclerosis. 61
33409820 2021
21
The Understanding of Pediatric Akinetic Mutism. 61
33542880 2021
22
Even a Mild Sleep Restriction Can Impact Daytime Functioning in Children with ADHD and Their Typically Developing Peers. 61
33455462 2021
23
Cognitive and emotional symptoms in patients with first-ever mild stroke: The syndrome of hidden impairments. 61
33145603 2021
24
The effect of medication and question wording on self-reported symptoms and their accuracy in young adults with attention-deficit/hyperactivity disorder. 61
33393098 2021
25
Treatment of pseudobulbar affect (PBA) in a patient with a history of traumatic brain injury, partial brain resection, and brainstem stroke: a case report. 61
33272325 2020
26
Living With the Burden of Pseudobulbar Affect: A Qualitative Analysis of the Effects of Education on Patient Experience. 61
33457582 2020
27
Investigating neural circuits of emotion regulation to distinguish euthymic patients with bipolar disorder and major depressive disorder. 61
33369067 2020
28
The Characteristics and Age Effects of Emotional Lability in ADHD Children With and Without Oppositional Defiant Disorder. 61
29224418 2020
29
Comorbid Internalizing and Externalizing Disorders Predict Lability of Negative Emotions Among Children With ADHD. 61
28992752 2020
30
A Measure of Emotional Regulation and Irritability in Children and Adolescents: The Clinical Evaluation of Emotional Regulation-9. 61
29094639 2020
31
Parental depressive symptoms, parent-child dyadic behavioral variability, and child dysregulation. 61
33180517 2020
32
The Role of Negative Affect in Differentiating Posttraumatic Stress Disorder, Depression, and Their Comorbidity Among United States Veterans. 61
33174307 2020
33
PID-5 Trait Indicators of Emotional Instability and Childhood Adversity Antecedents. 61
33215552 2020
34
How personality traits affect functional outcomes in patients with multiple sclerosis: A scoping review on a poorly understood topic. 61
33049463 2020
35
Rare case of bilateral carotid artery dissection presenting with Foix-Chavany-Marie syndrome. 61
33257395 2020
36
Executive functions, effortful control, and emotional lability in adults with ADHD. implications for functional outcomes. 61
32798933 2020
37
Development and psychometric properties of the ADHD-SCL-90-R screening scale for adult ADHD. 61
33188720 2020
38
Pediatric Acute-Onset Neuropsychiatric Syndrome: A Data Mining Approach to a Very Specific Constellation of Clinical Variables. 61
32460516 2020
39
Emotional Lability at Disease Onset Is an Independent Prognostic Factor of Faster Disease Progression in Amyotrophic Lateral Sclerosis. 61
33014519 2020
40
Defining the clinical, molecular and imaging spectrum of adaptor protein complex 4-associated hereditary spastic paraplegia. 61
32979048 2020
41
Neuroplasticity Improves Bipolar Disorder: A Review. 61
33274124 2020
42
Integrity of Amygdala Subregion-Based Functional Networks and Emotional Lability in Drug-Naïve Boys With ADHD. 61
27503948 2020
43
Prenatal and early childhood exposure to phthalates and childhood behavior at age 7 years. 61
32679391 2020
44
Towards a detailed understanding of preschool children's memory-related functioning and emotion regulation: The role of parents' observed reminiscence style, memory valence, and parental gender. 61
32614208 2020
45
Distinguishing burnout from depression: An exploratory qualitative study. 61
32554182 2020
46
Pseudobulbar Affect: An Overview. 61
32609863 2020
47
Polish adaptation of the Prodromal Questionnaire-Brief version PQ-B(PL) in psychiatric patients and healthy persons. 61
33386725 2020
48
The Effects of Inattentiveness and Hyperactivity on Posttraumatic Stress Symptoms: Does a Diagnosis of Posttraumatic Stress Disorder Matter? 61
25882836 2020
49
Not Your Average Seizure: A Case of N-Methyl-D-Aspartate Receptor Encephalitis and Review of Literature. 61
32714709 2020
50
Neuropsychiatric symptoms as the only acute manifestation of a stroke in the left hemisphere. Case report. 61
32888663 2020

Variations for Pseudobulbar Affect

Expression for Pseudobulbar Affect

Search GEO for disease gene expression data for Pseudobulbar Affect.

Pathways for Pseudobulbar Affect

GO Terms for Pseudobulbar Affect

Sources for Pseudobulbar Affect

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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