Aliases & Classifications for Pseudobulbar Palsy

MalaCards integrated aliases for Pseudobulbar Palsy:

Name: Pseudobulbar Palsy 12 44 15 73
Pseudobulbar Paralysis 12 29

Classifications:



External Ids:

Disease Ontology 12 DOID:12680
ICD9CM 35 335.23
MeSH 44 D020828
NCIt 50 C129934
SNOMED-CT 68 7379000
UMLS 73 C0033790

Summaries for Pseudobulbar Palsy

Disease Ontology : 12 A brain disease that is characterized by damage to neurons of the corticobulbar tract, has symptom dysarthria, has symptom dysphagia, has symptom spasticity located in tongue, has symptom abnormal bulbar reflexes, and has symptom emotional outbursts.

MalaCards based summary : Pseudobulbar Palsy, also known as pseudobulbar paralysis, is related to cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 and kuzniecky andermann syndrome, and has symptoms including spasticity, dysarthria and dysphagia. An important gene associated with Pseudobulbar Palsy is NOTCH3 (Notch 3), and among its related pathways/superpathways are Pre-NOTCH Expression and Processing and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include tongue, brain and bone, and related phenotypes are growth/size/body region and nervous system

Wikipedia : 76 Pseudobulbar palsy is a medical condition characterized by the inability to control facial movements... more...

Related Diseases for Pseudobulbar Palsy

Diseases related to Pseudobulbar Palsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 31)
# Related Disease Score Top Affiliating Genes
1 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 31.6 HTRA1 NOTCH3 NOTCH4
2 kuzniecky andermann syndrome 11.4
3 polymicrogyria, bilateral perisylvian, x-linked 11.2
4 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2 11.2
5 dementia 10.2
6 dystonia 10.2
7 amyotrophic lateral sclerosis 1 10.1
8 supranuclear palsy, progressive, 1 10.1
9 epilepsy 10.1
10 lateral sclerosis 10.1
11 dysphagia 10.1
12 malaria 10.0
13 chorioretinal scar 10.0 NOTCH3 NOTCH4
14 atypical choroid plexus papilloma 10.0 NOTCH3 NOTCH4
15 creutzfeldt-jakob disease 10.0
16 sleeping sickness 10.0
17 trypanosomiasis 10.0
18 endocarditis 10.0
19 antiphospholipid syndrome 10.0
20 progressive multifocal leukoencephalopathy 10.0
21 petroclival meningioma 10.0
22 speech disorder 10.0
23 encephalitis 10.0
24 trypanosomiasis, human east-african 10.0
25 encephalopathy 10.0
26 hajdu-cheney syndrome 10.0 NOTCH3 NOTCH4
27 venous malformations, multiple cutaneous and mucosal 10.0 NOTCH3 NOTCH4
28 cerebral degeneration 9.9 HTRA1 NOTCH3 NOTCH4
29 band heterotopia 9.8 SIX3 SRPX2
30 periventricular nodular heterotopia 9.6 ARFGEF2 SIX3 SRPX2
31 congenital nervous system abnormality 9.6 ARFGEF2 SIX3

Comorbidity relations with Pseudobulbar Palsy via Phenotypic Disease Network (PDN): (show all 12)


Acute Cystitis Cerebral Atherosclerosis
Decubitus Ulcer Deficiency Anemia
Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation Heart Disease
Hypertension, Essential Parkinson Disease, Late-Onset
Protein-Energy Malnutrition Schizophreniform Disorder
Swallowing Disorders Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Pseudobulbar Palsy:



Diseases related to Pseudobulbar Palsy

Symptoms & Phenotypes for Pseudobulbar Palsy

Symptoms:

12
  • spasticity
  • dysarthria
  • dysphagia
  • abnormal bulbar reflexes
  • emotional outbursts

UMLS symptoms related to Pseudobulbar Palsy:


hemiplegia, ophthalmoplegia, pseudobulbar signs, pseudobulbar behavioral symptoms

MGI Mouse Phenotypes related to Pseudobulbar Palsy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.63 ARFGEF2 HTRA1 KIF1BP NOTCH3 NOTCH4 SIX3
2 nervous system MP:0003631 9.43 ARFGEF2 KIF1BP NOTCH3 NOTCH4 SIX3 SRPX2
3 vision/eye MP:0005391 9.02 HTRA1 KIF1BP NOTCH3 NOTCH4 SIX3

Drugs & Therapeutics for Pseudobulbar Palsy

Search Clinical Trials , NIH Clinical Center for Pseudobulbar Palsy

Cochrane evidence based reviews: pseudobulbar palsy

Genetic Tests for Pseudobulbar Palsy

Genetic tests related to Pseudobulbar Palsy:

# Genetic test Affiliating Genes
1 Pseudobulbar Paralysis 29

Anatomical Context for Pseudobulbar Palsy

MalaCards organs/tissues related to Pseudobulbar Palsy:

41
Tongue, Brain, Bone, Cerebellum, Trachea

The Foundational Model of Anatomy Ontology organs/tissues related to Pseudobulbar Palsy:

19
Tongue

Publications for Pseudobulbar Palsy

Articles related to Pseudobulbar Palsy:

(show top 50) (show all 51)
# Title Authors Year
1
Hashimoto's encephalopathy presenting as pseudobulbar palsy. ( 29368307 )
2018
2
Acute Pseudobulbar Palsy After Bilateral Paramedian Thalamic Infarction: A Case Report. ( 27606284 )
2016
3
Pseudobulbar palsy due to deep-brain stimulation of the thalamic ventral intermediate nuclei. ( 25839917 )
2015
4
Consecutive Lacunar Strokes Mimicking Brainstem Symptoms in a Patient With Pseudobulbar Palsy. ( 26185957 )
2015
5
Pseudobulbar palsy due to bilateral injuries of corticobulbar tracts in a stroke patient. ( 26202710 )
2015
6
Neurocysticercosis presenting as pseudobulbar palsy. ( 24741260 )
2014
7
Progressive supranuclear palsy: a heterogeneous degeneration involving the brain stem, Basal Ganglia and cerebellum with vertical gaze and pseudobulbar palsy, nuchal dystonia and dementia. ( 24963673 )
2014
8
Pseudobulbar paralysis in the Renaissance: Cosimo I de' Medici case. ( 24604411 )
2014
9
Pure pseudobulbar palsy due to a capsular infarction. ( 22504270 )
2012
10
Dental management of the tropical disease human African trypanosomiasis: an unusual case of pseudobulbar palsy. ( 21217721 )
2011
11
Pseudobulbar palsy and affect in a case of progressive multifocal leukoencephalopathy. ( 18305298 )
2008
12
Thirty-six cases of pseudobulbar palsy treated by needling with prompt and deep insertion. ( 17078444 )
2006
13
Bilateral perisylvian ulegyria: clinicopathological study of patients presenting with pseudobulbar palsy and epilepsy. ( 16771181 )
2006
14
Acute pseudobulbar palsy due to methotrexate with rapid response to intravenous immunoglobulin. ( 16314998 )
2005
15
Acute pseudobulbar palsy as the initial presentation of intravascular lymphomatosis. ( 15172029 )
2004
16
Treatment of pseudobulbar paralysis by scalp acupuncture and sublingual needling. ( 15119166 )
2004
17
Clinical study on acupuncture treatment of pseudobulbar paralysis. ( 15270269 )
2004
18
Pseudobulbar palsy caused by a large petroclival meningioma: report of two cases. ( 17167648 )
2002
19
Left atrial myxoma presenting as pseudobulbar palsy. ( 12134197 )
2002
20
Primary antiphospholipid syndrome presenting as pseudobulbar palsy in a young male. ( 11848316 )
2001
21
Pseudobulbar paralysis treated by acupuncture--clinical observation in 36 cases. ( 11360528 )
2001
22
Creutzfeldt-Jakob disease presenting as isolated dysarthria and dysphagia due to pseudobulbar palsy. ( 10965170 )
2000
23
Pseudobulbar palsy recovery following HSV encephalitis in AIDS. ( 10726949 )
2000
24
Clinical observations on acupuncture treatment of pseudobulbar palsy--a report of 325 cases. ( 10453580 )
1999
25
Analysis of speech disorders in acute pseudobulbar palsy: a longitudinal study of a patient with lingual paralysis. ( 9926359 )
1998
26
120 cases of pseudobulbar paralysis treated by needling lianquan and chize. ( 10437223 )
1998
27
Relation between cognitive dysfunction and pseudobulbar palsy in amyotrophic lateral sclerosis. ( 9153602 )
1997
28
Bilateral thalamic infarcts presenting as acute pseudobulbar palsy. ( 7750810 )
1994
29
Pseudobulbar palsy associated with trismus. ( 7824418 )
1994
30
Bulbar and pseudobulbar palsy complicating therapy with high-dose cytosine arabinoside in children with leukemia. ( 2011096 )
1991
31
Combined application of scalp and body acupuncture in the treatment of pseudobulbar paralysis. ( 1749259 )
1991
32
Pseudobulbar palsy: a clinical computed tomography study. ( 2298226 )
1990
33
Bilateral central macrogyria: epilepsy, pseudobulbar palsy, and mental retardation--a recognizable neuronal migration disorder. ( 2500888 )
1989
34
Is the syndrome of pathological laughing and crying a manifestation of pseudobulbar palsy? ( 2738597 )
1989
35
Acute pseudobulbar palsy due to bilateral focal cortical damage: the opercular syndrome of Foix-Chavany-Marie. ( 2715610 )
1989
36
Lacunae and cribriform cavities of the brain. Correlations with pseudobulbar palsy and parkinsonism. ( 3366147 )
1988
37
Neoplastic obstruction of the trachea complicating pseudobulbar palsy. ( 3406789 )
1988
38
Trismus in pseudobulbar palsy. ( 4093375 )
1985
39
Pseudobulbar palsy after carotid endarterectomy. ( 4047367 )
1985
40
Pseudobulbar palsy after posterior fossa operation in children. ( 6504288 )
1984
41
Patterns of dysarthric movement in patients with amyotrophic lateral sclerosis and pseudobulbar palsy. ( 7129273 )
1982
42
Lithium carbonate in pseudobulbar palsy. ( 6782937 )
1981
43
Dysphagia of pseudobulbar palsy successfully treated by hypnosis. ( 6929999 )
1980
44
Control of emotional expression in pseudobulbar palsy. A personal experience. ( 911237 )
1977
45
Pseudobulbar palsy. ( 5419589 )
1970
46
Bacterial endocarditis presenting as pseudobulbar palsy. ( 6053619 )
1967
47
SUPRANUCLEAR (PSEUDOBULBAR) PALSY. ( 14332003 )
1965
48
PROGRESSIVE SUPRANUCLEAR PALSY. A HETEROGENEOUS DEGENERATION INVOLVING THE BRAIN STEM, BASAL GANGLIA AND CEREBELLUM WITH VERTICAL GAZE AND PSEUDOBULBAR PALSY, NUCHAL DYSTONIA AND DEMENTIA. ( 14107684 )
1964
49
SUPRANUCLEAR OPHTHALMOPLEGIA, PSEUDOBULBAR PALSY, NUCHAL DYSTONIA AND DEMENTIA. A CLINICAL REPORT ON EIGHT CASES OF "HETEROGENOUS SYSTEM DEGENERATION". ( 14272249 )
1963
50
Supranuclear bulbar palsy (pseudobulbar palsy) in mitral stenosis. ( 14777908 )
1950

Variations for Pseudobulbar Palsy

Expression for Pseudobulbar Palsy

Search GEO for disease gene expression data for Pseudobulbar Palsy.

Pathways for Pseudobulbar Palsy

GO Terms for Pseudobulbar Palsy

Cellular components related to Pseudobulbar Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi membrane GO:0000139 8.8 ARFGEF2 NOTCH3 NOTCH4

Biological processes related to Pseudobulbar Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.46 KIF1BP NOTCH3 NOTCH4 SIX3
2 Notch signaling pathway GO:0007219 9.37 NOTCH3 NOTCH4
3 negative regulation of cell differentiation GO:0045596 9.32 NOTCH3 NOTCH4
4 negative regulation of neuron differentiation GO:0045665 9.26 NOTCH3 SIX3
5 positive regulation of transcription of Notch receptor target GO:0007221 8.96 NOTCH3 NOTCH4
6 regulation of developmental process GO:0050793 8.62 NOTCH3 NOTCH4

Sources for Pseudobulbar Palsy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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