MCID: PSD001
MIFTS: 42

Pseudobulbar Palsy

Categories: Neuronal diseases, Oral diseases

Aliases & Classifications for Pseudobulbar Palsy

MalaCards integrated aliases for Pseudobulbar Palsy:

Name: Pseudobulbar Palsy 12 43 15 17 71
Pseudobulbar Paralysis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12680
ICD9CM 34 335.23
MeSH 43 D020828
NCIt 49 C129934
SNOMED-CT 67 7379000
UMLS 71 C0033790

Summaries for Pseudobulbar Palsy

Disease Ontology : 12 A brain disease that is characterized by damage to neurons of the corticobulbar tract, has symptom dysarthria, has symptom dysphagia, has symptom spasticity located in tongue, has symptom abnormal bulbar reflexes, and has symptom emotional outbursts.

MalaCards based summary : Pseudobulbar Palsy, also known as pseudobulbar paralysis, is related to cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2 and cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1, and has symptoms including spasticity, dysphagia and dysarthria. An important gene associated with Pseudobulbar Palsy is NOTCH3 (Notch Receptor 3), and among its related pathways/superpathways is Olfactory transduction. The drugs Nicotinamide and Tacrolimus have been mentioned in the context of this disorder. Affiliated tissues include tongue, brain and liver.

Wikipedia : 74 Pseudobulbar palsy is a medical condition characterized by the inability to control facial movements... more...

Related Diseases for Pseudobulbar Palsy

Diseases related to Pseudobulbar Palsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Related Disease Score Top Affiliating Genes
1 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2 32.7 NOTCH3 HTRA1
2 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 32.0 NOTCH3 HTRA1
3 aphasia 30.0 TARDBP SRPX2 C9orf72
4 motor neuron disease 11.7
5 kuzniecky andermann syndrome 11.6
6 polymicrogyria, bilateral perisylvian, x-linked 11.4
7 neurodevelopmental disorder with spastic quadriplegia, optic atrophy, seizures, and structural brain anomalies 11.4
8 dysphagia 10.6
9 col4a1-related familial vascular leukoencephalopathy 10.4 NOTCH3 HTRA1
10 vasculopathy, retinal, with cerebral leukodystrophy 10.4 NOTCH3 HTRA1
11 arteriolosclerosis 10.3 TARDBP NOTCH3 HTRA1
12 amyotrophic lateral sclerosis 1 10.3
13 supranuclear palsy, progressive, 1 10.3
14 lateral sclerosis 10.3
15 dystonia 10.3
16 speech disorder 10.3
17 encephalitis 10.3
18 spastic paraplegia 62, autosomal recessive 10.2 ZNF646 RNF170
19 amyotrophic lateral sclerosis type 22 10.2 TARDBP C9orf72
20 visual epilepsy 10.2
21 pseudobulbar affect 10.2
22 seizure disorder 10.2
23 associative agnosia 10.2 TARDBP C9orf72
24 frontotemporal dementia and/or amyotrophic lateral sclerosis 3 10.2 TARDBP C9orf72
25 ataxia, sensory, 1, autosomal dominant 10.2 ZNF646 RNF170
26 semantic dementia 10.2 TARDBP C9orf72
27 nominal aphasia 10.2 TARDBP C9orf72
28 agraphia 10.1 TARDBP C9orf72
29 dysgraphia 10.1 TARDBP C9orf72
30 pica disease 10.1 TARDBP C9orf72
31 writing disorder 10.1 TARDBP C9orf72
32 amyotrophic lateral sclerosis 10 with or without frontotemporal dementia 10.1 TARDBP C9orf72
33 amyotrophic lateral sclerosis type 6 10.1 TARDBP C9orf72
34 amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 10.0 TARDBP C9orf72
35 malaria 10.0
36 alcohol-related neurodevelopmental disorder 10.0
37 stuttering 10.0
38 status epilepticus 10.0
39 mutism 10.0
40 gillespie syndrome 10.0 ZNF646 RNF170
41 progressive muscular atrophy 10.0 TARDBP NOTCH3 C9orf72
42 amyotrophic lateral sclerosis 8 10.0 TARDBP C9orf72
43 creutzfeldt-jakob disease 10.0
44 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.0
45 parkinson disease 15, autosomal recessive early-onset 10.0
46 ataxia and polyneuropathy, adult-onset 10.0
47 kearns-sayre syndrome 10.0
48 meningioma, radiation-induced 10.0
49 meningioma, familial 10.0
50 human immunodeficiency virus type 1 10.0

Comorbidity relations with Pseudobulbar Palsy via Phenotypic Disease Network (PDN): (show all 12)


Acute Cystitis Cerebral Atherosclerosis
Decubitus Ulcer Deficiency Anemia
Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation Heart Disease
Hypertension, Essential Parkinson Disease, Late-Onset
Protein-Energy Malnutrition Schizophreniform Disorder
Swallowing Disorders Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Pseudobulbar Palsy:



Diseases related to Pseudobulbar Palsy

Symptoms & Phenotypes for Pseudobulbar Palsy

Symptoms:

12
  • spasticity
  • dysphagia
  • dysarthria
  • abnormal bulbar reflexes
  • emotional outbursts

UMLS symptoms related to Pseudobulbar Palsy:


ophthalmoplegia, hemiplegia, pseudobulbar behavioral symptoms, pseudobulbar signs

Drugs & Therapeutics for Pseudobulbar Palsy

Drugs for Pseudobulbar Palsy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nicotinamide Approved, Investigational 98-92-0 936
2
Tacrolimus Approved, Investigational 104987-11-3 445643 439492 6473866
3
Folic acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
4
Niacin Approved, Investigational, Nutraceutical 59-67-6 938
5
Creatine Approved, Investigational, Nutraceutical 57-00-1 586
6 Micronutrients
7 Vitamins
8 Trace Elements
9 Vitamin B Complex
10 Nicotinic Acids
11 Vitamin B3
12 Vasodilator Agents
13 Folate
14 Nutrients
15 Lipid Regulating Agents
16 pyruvate
17 Hypolipidemic Agents
18 Vitamin B9
19 Antimetabolites
20 Liver Extracts

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Autologous Purified Bone-Marrow-Derived Stem Cell Therapy for Motor Neuron Disease Unknown status NCT03067857 Phase 1, Phase 2
2 Functional Assessment of the Melanopsin-Containing Retinal Ganglion Cells in Progressive Supranuclear Palsy Using Chromatic Pupillometry Unknown status NCT03330353
3 Energy Metabolism in Neurodegenerative Diseases: A Randomized, Double Blind, Placebo-Controlled Clinical Pilot Trial of Pyruvate, Creatine, and Niacinamide in Progressive Supranuclear Palsy. Completed NCT00605930
4 Perioperative Optic Nerve Sheath Diameter As A Predictor Of Early Tacrolimus Neurotoxicity In Living Donor Liver Transplantation Recruiting NCT03799770
5 Respiratory Complications Associated With ALS and Their Treatments Not yet recruiting NCT04430686

Search NIH Clinical Center for Pseudobulbar Palsy

Cochrane evidence based reviews: pseudobulbar palsy

Genetic Tests for Pseudobulbar Palsy

Anatomical Context for Pseudobulbar Palsy

The Foundational Model of Anatomy Ontology organs/tissues related to Pseudobulbar Palsy:

19
Tongue

MalaCards organs/tissues related to Pseudobulbar Palsy:

40
Tongue, Brain, Liver, Bone, Pituitary, Cerebellum, Testes

Publications for Pseudobulbar Palsy

Articles related to Pseudobulbar Palsy:

(show top 50) (show all 399)
# Title Authors PMID Year
1
Phenotypic variability and mutation hotspot in COX15-related Leigh syndrome. 61
32232962 2020
2
Pediatric post-operative cerebellar mutism syndrome, cerebellar cognitive affective syndrome, and posterior fossa syndrome: historical review and proposed resolution to guide future study. 61
31240391 2020
3
[Fire needling on dysphagia due to pseudobulbar palsy after stroke: a randomized controlled trial]. 61
32275359 2020
4
Thoracic Dural Arteriovenous Fistula Presenting with Isolated Pseudobulbar Palsy Mimicking Brainstem Lesion. 61
31954916 2020
5
The Progressive Supranuclear Palsy: Past and Present Aspects. 61
31752626 2020
6
Jaw clonus in neuromyelitis optica spectrum disorder with subsequent osmotic demyelination syndrome. 61
32318496 2020
7
Inability to close mouth and dysphagia caused by pseudobulbar palsy: trial treatment by vibration-induced mastication-like movement. 61
31892622 2019
8
Foix-Chavany-Marie Syndrome due to Unilateral Anterior Opercular Damage with Contralateral Infarction of Corona Radiata. 61
31824287 2019
9
CADASIL with Atypical Clinical Symptoms, Magnetic Resonance Imaging, and Novel Mutations: Two Case Reports and a Review of the Literature. 61
30993645 2019
10
The CADASIL Scale-J, A Modified Scale to Prioritize Access to Genetic Testing for Japanese CADASIL-Suspected Patients. 61
30956055 2019
11
Story of the ALS-FTD continuum retold: rather two distinct entities. 61
30257969 2019
12
SEC31A mutation affects ER homeostasis, causing a neurological syndrome. 61
30464055 2019
13
[Foix-Chavany-Marie Syndrome: A Clinical Overview]. 61
30827960 2019
14
Foix-Chavany-Marie Syndrome Induced by a Unilateral Brain Abscess. 61
30210128 2019
15
[An Autopsy Case of Amiotrophic Lateral Sclerosis Characterized by Upper Motor Neuron Degeneration and Progressive Pseudobulbar Palsy]. 61
30630132 2019
16
An Analysis of Clinical Characteristics of Rare Bilateral Cerebral Peduncular Infarction. 61
31708855 2019
17
Global, regional, and national burden of motor neuron diseases 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. 61
30409709 2018
18
Hashimoto's encephalopathy presenting as pseudobulbar palsy. 61
29368307 2018
19
[Therapeutic effects of acupuncture combined with rehabilitation training on dysphagia in post-stroke pseudobulbar palsy]. 61
29696919 2018
20
Effects of nape acupuncture combined with swallowing rehabilitation on dysphagia in pseudobulbar palsy. 61
32185960 2018
21
[CADASIL with clinical manifestations of baldness, lumbago and Parkinson's symptoms]. 61
29188608 2017
22
Endoscopy in the treatment of slit ventricle syndrome. 61
29042922 2017
23
Multiple pseudofractures due to Fanconi's syndrome associated with Wilson's disease. 61
28855492 2017
24
[Effects of GAO's neck acupuncture on swallowing function and quality of life in patients with post-stroke pseudobulbar palsy:a randomized controlled trial]. 61
29231539 2017
25
Freezing of gait is an early clinical feature of progressive supranuclear palsy. 61
28702192 2017
26
Acute Psychosis as Main Manifestation of Central Pontine Myelinolysis. 61
28392953 2017
27
Outcomes of Palatal Lift Prosthesis on Dysarthric Speech. 61
27831974 2017
28
A Case Report of Isolated Bilateral Cerebral Peduncular Infarction. 61
29158929 2017
29
Bulbar dysfunction and aspiration pneumonia due to a brainstem haemangioblastoma: an unusual complication of von Hippel-Lindau disease. 61
27737868 2016
30
Acute Pseudobulbar Palsy After Bilateral Paramedian Thalamic Infarction: A Case Report. 61
27606284 2016
31
Those eyes don't lie: a case of osmotic demyelination syndrome in a patient with hepatic encephalopathy. 61
29536888 2016
32
Late-onset spastic paraplegia type 10 (SPG10) family presenting with bulbar symptoms and fasciculations mimicking amyotrophic lateral sclerosis. 61
27084214 2016
33
An unusual case of cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy with occipital lobe involvement. 61
27293347 2016
34
Tongguan Liqiao acupuncture therapy improves dysphagia after brainstem stroke. 61
27073382 2016
35
Progressive supranuclear palsy: progression and survival. 61
26705121 2016
36
The phenotypic spectrum of progressive supranuclear palsy. 61
26421392 2016
37
LMNB1-related autosomal-dominant leukodystrophy: Clinical and radiological course. 61
26053668 2015
38
[TRANSIENT PSEUDOBULBAR SYNDROME IN UNILATERAL FRONTAL OPERCULAR INFARCTS]. 61
26665496 2015
39
Pseudobulbar palsy due to bilateral injuries of corticobulbar tracts in a stroke patient. 61
26202710 2015
40
Consecutive Lacunar Strokes Mimicking Brainstem Symptoms in a Patient With Pseudobulbar Palsy. 61
26185957 2015
41
Pseudobulbar palsy due to deep-brain stimulation of the thalamic ventral intermediate nuclei. 61
25839917 2015
42
Accelerated neuronal differentiation toward motor neuron lineage from human embryonic stem cell line (H9). 61
25036750 2015
43
Focal increased 18F FP-CIT uptake in a recent ischemic lesion in the frontal lobe. 61
25140548 2015
44
Progressive supranuclear palsy: what do we know about it? 61
25732053 2015
45
Extremely severe complicated spastic paraplegia 3A with neonatal onset. 61
25193411 2014
46
Bilateral anterior choroidal artery infarction presenting with progressive somnolence. 61
25106836 2014
47
Voxel-based morphometry and intellectual assessment in patients with congenital bilateral perisylvian syndrome. 61
24781839 2014
48
Pseudobulbar paralysis in the Renaissance: Cosimo I de' Medici case. 61
24604411 2014
49
Frontotemporal lobar degeneration with writing disturbance mainly consisting of omission of kana letters. 61
23679336 2014
50
[Quality assessment on guidelines of clinical practice in acupuncture and moxibustion: a study based on AGREE]. 61
25112103 2014

Variations for Pseudobulbar Palsy

Expression for Pseudobulbar Palsy

Search GEO for disease gene expression data for Pseudobulbar Palsy.

Pathways for Pseudobulbar Palsy

Pathways related to Pseudobulbar Palsy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.05 OR52L1 OR52H1 OR4F4 OR2T1 OR1E1 OR10G8

GO Terms for Pseudobulbar Palsy

Biological processes related to Pseudobulbar Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.8 OR52L1 OR52H1 OR4F4 OR2T1 OR1E1 OR10G8
2 response to stimulus GO:0050896 9.63 OR52L1 OR52H1 OR4F4 OR2T1 OR1E1 OR10G8
3 detection of chemical stimulus involved in sensory perception of smell GO:0050911 9.43 OR52L1 OR52H1 OR4F4 OR2T1 OR1E1 OR10G8
4 regulation of phosphorylation GO:0042325 9.26 SRPX2 PPP1R14C
5 sensory perception of smell GO:0007608 9.1 OR52L1 OR52H1 OR4F4 OR2T1 OR1E1 OR10G8

Molecular functions related to Pseudobulbar Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor activity GO:0004930 9.43 OR52L1 OR52H1 OR4F4 OR2T1 OR1E1 OR10G8
2 protein serine/threonine phosphatase inhibitor activity GO:0004865 9.16 PPP1R2 PPP1R14C
3 olfactory receptor activity GO:0004984 9.1 OR52L1 OR52H1 OR4F4 OR2T1 OR1E1 OR10G8

Sources for Pseudobulbar Palsy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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