Pseudofolliculitis Barbae disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

UniProtKB/Swiss-Prot: ⁷³ A common hair disorder characterized by a pustular foreign body inflammatory reaction that is induced by ingrown hairs of the facial and submental (barbea) regions after regular shaving. It primarily affects curly haired males. The etiology of PFB is multifactorial.

MalaCards based summary: Pseudofolliculitis Barbae, also known as pili incarnati, is related to hair morphology 2 and acne. An important gene associated with Pseudofolliculitis Barbae is KRT75 (Keratin 75). The drugs Eflornithine and Ornithine have been mentioned in the context of this disorder. Affiliated tissues include skin.

Wikipedia: ⁷⁵ Pseudofolliculitis barbae (PFB) is a persistent irritation caused by shaving. It was first described in... more...

More information from OMIM: 612318

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Related Diseases for Pseudofolliculitis Barbae

Diseases related to Pseudofolliculitis Barbae via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)

#	Related Disease	Score
1	hair morphology 2	10.6
2	acne	10.5
3	chronic lymphocytic inflammation with pontine perivascular enhancement responsiv	10.4
4	hypertrophic scars	10.3
5	folliculitis	10.3
6	keloid disorder	10.3
7	dilution, pigmentary	10.2
8	hair whorl	10.2
9	keloid formation	10.2
10	sarcoidosis 1	10.2
11	steatocystoma multiplex	10.2
12	sarcoidosis 2	10.2
13	skin disease	10.2
14	hair disease	10.2
15	lymphatic system disease	10.2
16	rosacea	10.2
17	burkitt lymphoma	10.0

Graphical network of the top 20 diseases related to Pseudofolliculitis Barbae:

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Symptoms & Phenotypes for Pseudofolliculitis Barbae

Clinical features from OMIM®:

612318 (Updated 08-Dec-2022)

Sources

Drugs & Therapeutics for Pseudofolliculitis Barbae

Drugs for Pseudofolliculitis Barbae (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Eflornithine

Approved, Withdrawn

Phase 2

70052-12-9

3009

2

Ornithine

Approved, Nutraceutical

Phase 2

3184-13-2, 70-26-8

6262

3

Anti-Infective Agents

Phase 2

4

Antiprotozoal Agents

Phase 2

5

Antiparasitic Agents

Phase 2

6

Edetate calcium disodium anhydrous

Approved, Vet_approved

62-33-9, 60-00-4

6049

Synonyms:

(Ethylenedinitrilo)tetraacetate, ion(4-)

(ethylenedinitrilo)tetraacetic acid, ion(4−)

(Ethylenedinitrilo)tetraacetic acid, ion(4-)

{[-(bis-carboxymethyl-amino)-ethyl]-carboxymethyl-amino}-acetate

{[-(bis-carboxymethyl-amino)-ethyl]-carboxymethyl-amino}-acetIC ACID

2,2',2'',2'''-(ethane-1,2-diyldinitrilo)tetraacetate

2,2',2'',2'''-(ethane-1,2-diyldinitrilo)tetraacetic acid

Acid, edetic

Acid, ethylenediaminetetraacetic

Acid, ethylenedinitrilotetraacetic

Acide edetique

Acide ethylenediaminetetracetique

Acido edetico

Acidum edeticum

CaEDTA

Calcioedetato de sodio

Calcitetracemate, disodium

Calcium disodium edetate

Calcium disodium edetic acid

Calcium disodium edta

Calcium disodium ethylenediamine tetraacetate

Calcium disodium ethylenediamine tetraacetic acid

Calcium disodium ethylenediaminetetraacetate

Calcium disodium ethylenediaminetetraacetic acid

Calcium disodium versenate

Calcium disodium versenic acid

Calcium edetate de sodium

CALCIUM EDETATE SODIUM

Calcium edetic acid de sodium

Calcium edta

Calcium sodium 2,2',2'',2'''-(ethane-1,2-diyldinitrilo)tetraacetate (1/2/1)

Calcium sodium 2,2',2'',2'''-(ethane-1,2-diyldinitrilo)tetraacetic acid (1/2/1)

CALCIUM SODIUM EDETATE HYDRATE

Calcium sodium edta

Calcium tetacine

CaNa2Edta

Chelaton 3

Chromium edta

Copper edta

Coprin

Dicobalt edta

Dinitrilotetraacetate, disodium ethylene

Dinitrilotetraacetate, ethylene

Disodium calcitetracemate

Disodium calcium edta

Disodium calcium ethylenediaminetetraacetate

Disodium calcium ethylenediaminetetraacetic acid

Disodium edta

Disodium ethylene dinitrilotetraacetate

Disodium monocalcium edta

Disodium versenate, calcium

Distannous edta

E385

Edathamil

Edetate

Edetate calcium

Edetate calcium disodium

Edetate calcium disodium (anhydrous)

Edetate disodium calcium

Edetate, calcium disodium

Edetates

Edetic acid

Edetic acid calcium disodium

Edetic acid calcium disodium (anhydrous)

Edetic acid calcium disodium salt

Edetic acid, calcium salt

Edetic acid, calcium, sodium salt

Edetic acid, chromium salt

Edetic acid, dipotassium salt

Edetic acid, disodium salt

Edetic acid, disodium salt, dihydrate

Edetic acid, disodium, magnesium salt

Edetic acid, disodium, monopotassium salt

Edetic acid, magnesium salt

Edetic acid, monopotassium salt

Edetic acid, monosodium salt

Edetic acid, potassium salt

Edetic acid, sodium salt

EDT

EDTA

EDTA CALCIUM DISODIUM

EDTA calcium disodium salt

EDTA disodium calcium salt

EDTA, calcium derivative, disodium salt

EDTA, chromium

EDTA, copper

EDTA, dicobalt

EDTA, disodium

EDTA, distannous

EDTA, gallium

EDTA, ion(4-)

EDTA, magnesium disodium

EDTA, potassium

EDTA, stannous

EDTHAMIL

Ethylene dinitrilotetraacetate

Ethylene dinitrilotetraacetate, disodium

Ethylenediaminetetraacetate

Ethylenediaminetetraacetate calcium disodium salt

Ethylenediaminetetraacetic acid

Ethylenediaminetetraacetic acid calcium disodium salt

Ethylenedinitrilotetraacetic acid

Gallium edta

H4EDta

Magnesium disodium edta

Monocalcium disodium edta

N,N'-1,2-ethane diylbis-(N-(carboxymethyl)glycine)

N,N'-1,2-ethanediylbis(N-(carboxymethyl)glycine)

Natrii calcii edetas

Potassium edta

Sodium calcium edetate

Sodium calcium edetic acid

SODIUM CALCIUMEDETATE

Stannous edta

Tetacine, calcium

Tetracemate

Versenate

Versenate, calcium disodium

Versene

Versene acid

VERSENE CA

7

Pentetic acid

Approved

67-43-6

8

Polidocanol

Approved

9002-92-0

78933

9

Petrolatum

Approved, Investigational

8009-03-8

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Topical Eflornithine Hydrochloride for Pseudofolliculitis Barbae: A Randomized, Double-blinded, Placebo-controlled Trial	Unknown status	NCT04403282	Phase 4	Eflornithine Topical;Placebo Eflornithine Topical
2	Phase II, Open-Label Study of the Effect of 15% Eflornithine Hydrochloride Cream on Facial Hair of Men of African-American Descent With Pseudofolliculitis Barbae: A Laser Scanning Confocal Microscopy and Video Imaging Study	Completed	NCT00176995	Phase 2	15% Eflornithine Hdyrochloride
3	The Impact of a Pre-Shave Gel and Brush in Males With Pseudofolliculitis Barbae	Completed	NCT03043534
4	Clinical Safety and Efficacy of Prototype Devices for Hair Growth Control: Task 2.4	Completed	NCT00402129
5	The Impact of the 556 Razor Technology and of a Regimen of the 556 Razor Technology With Pre-Shave Gel and Brush on Shaving Satisfaction in Males With Skin Irritation From Shaving	Active, not recruiting	NCT03569956
6	Clinical Evaluation to Assess the Safety and Efficacy of GentleMax Pro/ GentleMax Pro Plus	Active, not recruiting	NCT04993066
7	Depilatory Cream's Affect on the Occurrence of Pseudofolliculitis Barbae	Withdrawn	NCT04220502	Early Phase 1	Magic Shave Powder Gold

Search NIH Clinical Center for Pseudofolliculitis Barbae

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Genetic Tests for Pseudofolliculitis Barbae

Genetic tests related to Pseudofolliculitis Barbae:

#	Genetic test	Affiliating Genes
1	Pseudofolliculitis Barbae ²⁸	KRT75

Sources

Anatomical Context for Pseudofolliculitis Barbae

Organs/tissues related to Pseudofolliculitis Barbae:

MalaCards : Skin

Sources

Publications for Pseudofolliculitis Barbae

Articles related to Pseudofolliculitis Barbae:

(show top 50) (show all 109)

#	Title	Authors	PMID	Year
1	An unusual Ala12Thr polymorphism in the 1A alpha-helical segment of the companion layer-specific keratin K6hf: evidence for a risk factor in the etiology of the common hair disorder pseudofolliculitis barbae. ⁶² ⁵⁷ ⁵	Winter H...Schweizer J	15086549	2004
2	The causes and treatment of pseudofolliculitis barbae. ⁶² ⁵⁷	Crutchfield CE	9640558	1998
3	Pseudofolliculitis barbae associated with an unusual hair whorl. ⁶² ⁵⁷	Ross EV...Yeager JK	8453890	1993
4	Pseudofolliculitis Barbae. ⁶²	Patel TS...Dalia Y	35475875	2022
5	Ethnic Equity Implications in the Management of Pseudofolliculitis Barbae. ⁶²	Sharma D...Patel TS	35039424	2022
6	Health Care Equity for Family Medicine Patients and Family Physician Equity. ⁶²	Bowman MA...Ledford CJW	35039404	2022
7	Pseudofolliculitis barbae treatment: Efficacy of topical eflornithine, long-pulsed Nd-YAG laser versus their combination. ⁶²	Shokeir H...Taymour M	33629488	2021
8	Facial hair shaving behavior and skin problems of shaved areas of males. ⁶²	Sukakul T...Varothai S	34254359	2021
9	Shaving Waivers in the United States Air Force and Their Impact on Promotions of Black/African-American Members. ⁶²	Ritchie S...Beachkofsky T	34226933	2021
10	Pseudofolliculitis Barbae in the Military and the Need for Social Awareness. ⁶²	Okonkwo E...Harper HL	33560343	2021
11	Response to Letter to the Editor on Pseudofolliculitis Barbae in the Military and the Need for Social Justice. ⁶²	Tshudy MT...Cho S	33560347	2021
12	Evaluation of efficacy and safety of chemical peeling and long-pulse Nd:YAG laser in treatment of pseudofolliculitis barbae. ⁶²	Amer A...Gharib K	33559240	2021
13	[An introduction to skin disease in melanin rich skin]. ⁶²	Elyas A...Bradley M	33647160	2021
14	Pseudofolliculitis Barbae in the U.S. Military, a Review. ⁶²	Tshudy MT...Cho S	33128565	2020
15	Folliculitis Induced by Laser Hair Removal: Proposed Mechanism and Treatment. ⁶²	Schuler A...Tisack A	32802254	2020
16	Dermatologic Conditions in Transgender Populations. ⁶²	Yeung H...Tangpricha V	31027550	2019
17	Laser Treatment of Skin of Color for Medical and Aesthetic Uses With a New 650-Microsecond Nd:YAG 1064nm Laser ⁶²	Roberts WE...Campbell-Chambers DA	31017752	2019
18	Pseudofolliculitis Barbae: A Review of Current Treatment Options ⁶²	Nussbaum D...Friedman A	30909328	2019
19	Pseudofolliculitis barbae; current treatment options. ⁶²	Ogunbiyi A	31354326	2019
20	Ingrown Hairs: A Recurrent Trichoscopic Feature in Scarring Alopecias. ⁶²	Tavares IR...Pirmez R	30197897	2018
21	Coccidioides immitis soft tissue infection mimicking pseudofolliculitis barbae. ⁶²	Gerstein W...Ilieva V	29636956	2018
22	Barber Knowledge and Recommendations Regarding Pseudofolliculitis Barbae and Acne Keloidalis Nuchae in an Urban Setting. ⁶²	Adotama P...Allen P	29049485	2017
23	Considerations When Treating Cosmetic Concerns in Men of Color. ⁶²	Awosika O...Grimes PE	29064976	2017
24	Acne keloidalis nuchae: risk factors and associated disorders - a retrospective study. ⁶²	East-Innis ADC...Ho JD	28664654	2017
25	Hair and scalp disorders in adult and pediatric patients with skin of color. ⁶²	Taylor SC...Callender V	28873105	2017
26	Ethnic skin: Kids are not just little people. ⁶²	Shen LY...Kundu RV	27968928	2016
27	Bensal HP Attenuates the Inflammatory Response in Hair Shaving Associated Dermatitis. ⁶²	Ray A...Friedman A	27391633	2016
28	Pseudofolliculitis barbae: understanding the condition and the role of facial grooming. ⁶²	Gray J...McMichael AJ	27212468	2016
29	Laser and Light-Based Aesthetics in Men. ⁶²	Green JB...Keaney T	26355628	2015
30	Pseudofolliculitis barbae in women: a clinical perspective. ⁶²	Nguyen TA...Friedman AJ	25557018	2015
31	Clinical, dermoscopic, and histopathologic features of body hair disorders. ⁶²	Panchaprateep R...Tosti A	25748313	2015
32	The diverse application of laser hair removal therapy: a tertiary laser unit's experience with less common indications and a literature overview. ⁶²	Koch D...Abdullah A	24173910	2015
33	Ethnic hair disorders. ⁶²	Lindsey SF...Tosti A	26370652	2015
34	Red face revisited: Disorders of hair growth and the pilosebaceous unit. ⁶²	Ramos-e-Silva M...Pirmez R	25441472	2014
35	Follicular and scarring disorders in skin of color: presentation and management. ⁶²	Madu P...Kundu RV	24820821	2014
36	Complications related to pubic hair removal. ⁶²	DeMaria AL...Berenson AB	24486227	2014
37	Folliculitis keloidalis nuchae and pseudofolliculitis barbae: are prevention and effective treatment within reach? ⁶²	Alexis A...Halder RM	24680005	2014
38	Successful treatment of recalcitrant folliculitis barbae and pseudofolliculitis barbae with photodynamic therapy. ⁶²	Diernaes JE...Bygum A	24284123	2013
39	Dermatologic conditions in skin of color: part II. Disorders occurring predominately in skin of color. ⁶²	Kundu RV...Patterson S	23939568	2013
40	Pseudofolliculitis barbae: a dermatoscopic correlate. ⁶²	Ladizinski B...Elpern DJ	23785645	2013
41	Shave frequency and regimen variation effects on the management of pseudofolliculitis barbae. ⁶²	Daniel A...McMichael A	23652888	2013
42	Hair and scalp disorders in ethnic populations. ⁶²	Rodney IJ...Halder RM	23652889	2013
43	Topical eflornithine hydrochloride improves the effectiveness of standard laser hair removal for treating pseudofolliculitis barbae: a randomized, double-blinded, placebo-controlled trial. ⁶²	Xia Y...Maggio KL	22226431	2012
44	Pseudofolliculitis barbae induced by oral minoxidil. ⁶²	Liew HM...Bashir S	22607496	2012
45	Best practices and evidenced-based use of the 800 nm diode laser for the treatment of pseudofolliculitis barbae in skin of color. ⁶²	Emer JJ	22577689	2011
46	Keratin disorders: from gene to therapy. ⁶²	McLean WH...Moore CB	21890491	2011
47	[Frizzy hair pathology]. ⁶²	Morand JJ	22235613	2011
48	Comparative evaluation of men's depilatory composition versus razor in black men. ⁶²	Kindred C...Halder RM	21916277	2011
49	[Pseudofolliculitis and related disorders in skin of color]. ⁶²	Pierard-Franchimont C...Pierard GE	21560430	2011
50	[Pseudofolliculitis barbae]. ⁶²	Ribera M...Casals M	21034705	2010

Sources

Genes for Pseudofolliculitis Barbae

Genes related to Pseudofolliculitis Barbae (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	KRT75	Keratin 75	Protein Coding	692.49	Molecular basis known ⁵⁷ Genetic Tests ²⁸ Susceptibility factor ⁵⁷ Risk factor ⁵ GeneCards inferred via : Publications Summaries (show sections)	15086549

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Variations for Pseudofolliculitis Barbae

ClinVar genetic disease variations for Pseudofolliculitis Barbae:

⁵

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	Position
1	KRT75	NM_004693.3(KRT75):c.481G>A (p.Ala161Thr)	SNV	Risk Factor	1891	rs2232387	GRCh37: 12:52827608-52827608 GRCh38: 12:52433824-52433824

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Expression for Pseudofolliculitis Barbae

Search GEO for disease gene expression data for Pseudofolliculitis Barbae.

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Pathways for Pseudofolliculitis Barbae

Sources

GO Terms for Pseudofolliculitis Barbae

Sources

Sources for Pseudofolliculitis Barbae

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

PFB MCID: PSD078 MIFTS: 25	Pseudofolliculitis Barbae (PFB) Categories: Genetic diseases, Skin diseases	Data Licensing For inquiries, contact: [email protected]
Genes Variations Tissues Related diseases Publications Drugs Expand all tables

Pseudofolliculitis Barbae (PFB)

Aliases & Classifications for Pseudofolliculitis Barbae

MalaCards integrated aliases for Pseudofolliculitis Barbae:

Classifications:

External Ids:

Summaries for Pseudofolliculitis Barbae

Related Diseases for Pseudofolliculitis Barbae

Diseases related to Pseudofolliculitis Barbae via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Pseudofolliculitis Barbae:

Symptoms & Phenotypes for Pseudofolliculitis Barbae

Clinical features from OMIM®:

Drugs & Therapeutics for Pseudofolliculitis Barbae

Drugs for Pseudofolliculitis Barbae (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Genetic Tests for Pseudofolliculitis Barbae

Genetic tests related to Pseudofolliculitis Barbae:

Anatomical Context for Pseudofolliculitis Barbae

Organs/tissues related to Pseudofolliculitis Barbae:

Publications for Pseudofolliculitis Barbae

Articles related to Pseudofolliculitis Barbae:

Genes for Pseudofolliculitis Barbae

Genes related to Pseudofolliculitis Barbae (1 elite genes):

Variations for Pseudofolliculitis Barbae

ClinVar genetic disease variations for Pseudofolliculitis Barbae:

Expression for Pseudofolliculitis Barbae

Pathways for Pseudofolliculitis Barbae

GO Terms for Pseudofolliculitis Barbae

Sources for Pseudofolliculitis Barbae