PFB
MCID: PSD078
MIFTS: 25

Pseudofolliculitis Barbae (PFB)

Categories: Genetic diseases, Skin diseases
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Aliases & Classifications for Pseudofolliculitis Barbae

MalaCards integrated aliases for Pseudofolliculitis Barbae:

Name: Pseudofolliculitis Barbae 57 73 28 5 38 71 75 31
Pili Incarnati 57 73 71
Pseudofolliculitis Barbae, Susceptibility to 57 12
Ingrown Hairs 57 73
Pfb 57 73

Classifications:



External Ids:

OMIM® 57 612318
MeSH 43 D006201
ICD10 31 L73.1
MedGen 40 C0549150
UMLS 71 C0263492 C0549150

Summaries for Pseudofolliculitis Barbae

UniProtKB/Swiss-Prot: 73 A common hair disorder characterized by a pustular foreign body inflammatory reaction that is induced by ingrown hairs of the facial and submental (barbea) regions after regular shaving. It primarily affects curly haired males. The etiology of PFB is multifactorial.

MalaCards based summary: Pseudofolliculitis Barbae, also known as pili incarnati, is related to hair morphology 2 and acne. An important gene associated with Pseudofolliculitis Barbae is KRT75 (Keratin 75). The drugs Eflornithine and Ornithine have been mentioned in the context of this disorder. Affiliated tissues include skin.

Wikipedia: 75 Pseudofolliculitis barbae (PFB) is a persistent irritation caused by shaving. It was first described in... more...

More information from OMIM: 612318

Related Diseases for Pseudofolliculitis Barbae

Diseases related to Pseudofolliculitis Barbae via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
# Related Disease Score Top Affiliating Genes
1 hair morphology 2 10.6
2 acne 10.5
3 chronic lymphocytic inflammation with pontine perivascular enhancement responsiv 10.4
4 hypertrophic scars 10.3
5 folliculitis 10.3
6 keloid disorder 10.3
7 dilution, pigmentary 10.2
8 hair whorl 10.2
9 keloid formation 10.2
10 sarcoidosis 1 10.2
11 steatocystoma multiplex 10.2
12 sarcoidosis 2 10.2
13 skin disease 10.2
14 hair disease 10.2
15 lymphatic system disease 10.2
16 rosacea 10.2
17 burkitt lymphoma 10.0

Graphical network of the top 20 diseases related to Pseudofolliculitis Barbae:



Diseases related to Pseudofolliculitis Barbae

Symptoms & Phenotypes for Pseudofolliculitis Barbae

Clinical features from OMIM®:

612318 (Updated 08-Dec-2022)

Drugs & Therapeutics for Pseudofolliculitis Barbae

Drugs for Pseudofolliculitis Barbae (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Eflornithine Approved, Withdrawn Phase 2 70052-12-9 3009
2
Ornithine Approved, Nutraceutical Phase 2 3184-13-2, 70-26-8 6262
3 Anti-Infective Agents Phase 2
4 Antiprotozoal Agents Phase 2
5 Antiparasitic Agents Phase 2
6
Edetate calcium disodium anhydrous Approved, Vet_approved 62-33-9, 60-00-4 6049
7
Pentetic acid Approved 67-43-6
8
Polidocanol Approved 9002-92-0 78933
9
Petrolatum Approved, Investigational 8009-03-8

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Topical Eflornithine Hydrochloride for Pseudofolliculitis Barbae: A Randomized, Double-blinded, Placebo-controlled Trial Unknown status NCT04403282 Phase 4 Eflornithine Topical;Placebo Eflornithine Topical
2 Phase II, Open-Label Study of the Effect of 15% Eflornithine Hydrochloride Cream on Facial Hair of Men of African-American Descent With Pseudofolliculitis Barbae: A Laser Scanning Confocal Microscopy and Video Imaging Study Completed NCT00176995 Phase 2 15% Eflornithine Hdyrochloride
3 The Impact of a Pre-Shave Gel and Brush in Males With Pseudofolliculitis Barbae Completed NCT03043534
4 Clinical Safety and Efficacy of Prototype Devices for Hair Growth Control: Task 2.4 Completed NCT00402129
5 The Impact of the 556 Razor Technology and of a Regimen of the 556 Razor Technology With Pre-Shave Gel and Brush on Shaving Satisfaction in Males With Skin Irritation From Shaving Active, not recruiting NCT03569956
6 Clinical Evaluation to Assess the Safety and Efficacy of GentleMax Pro/ GentleMax Pro Plus Active, not recruiting NCT04993066
7 Depilatory Cream's Affect on the Occurrence of Pseudofolliculitis Barbae Withdrawn NCT04220502 Early Phase 1 Magic Shave Powder Gold

Search NIH Clinical Center for Pseudofolliculitis Barbae

Genetic Tests for Pseudofolliculitis Barbae

Genetic tests related to Pseudofolliculitis Barbae:

# Genetic test Affiliating Genes
1 Pseudofolliculitis Barbae 28 KRT75

Anatomical Context for Pseudofolliculitis Barbae

Organs/tissues related to Pseudofolliculitis Barbae:

MalaCards : Skin

Publications for Pseudofolliculitis Barbae

Articles related to Pseudofolliculitis Barbae:

(show top 50) (show all 109)
# Title Authors PMID Year
1
An unusual Ala12Thr polymorphism in the 1A alpha-helical segment of the companion layer-specific keratin K6hf: evidence for a risk factor in the etiology of the common hair disorder pseudofolliculitis barbae. 62 57 5
15086549 2004
2
The causes and treatment of pseudofolliculitis barbae. 62 57
9640558 1998
3
Pseudofolliculitis barbae associated with an unusual hair whorl. 62 57
8453890 1993
4
Pseudofolliculitis Barbae. 62
35475875 2022
5
Ethnic Equity Implications in the Management of Pseudofolliculitis Barbae. 62
35039424 2022
6
Health Care Equity for Family Medicine Patients and Family Physician Equity. 62
35039404 2022
7
Pseudofolliculitis barbae treatment: Efficacy of topical eflornithine, long-pulsed Nd-YAG laser versus their combination. 62
33629488 2021
8
Facial hair shaving behavior and skin problems of shaved areas of males. 62
34254359 2021
9
Shaving Waivers in the United States Air Force and Their Impact on Promotions of Black/African-American Members. 62
34226933 2021
10
Pseudofolliculitis Barbae in the Military and the Need for Social Awareness. 62
33560343 2021
11
Response to Letter to the Editor on Pseudofolliculitis Barbae in the Military and the Need for Social Justice. 62
33560347 2021
12
Evaluation of efficacy and safety of chemical peeling and long-pulse Nd:YAG laser in treatment of pseudofolliculitis barbae. 62
33559240 2021
13
[An introduction to skin disease in melanin rich skin]. 62
33647160 2021
14
Pseudofolliculitis Barbae in the U.S. Military, a Review. 62
33128565 2020
15
Folliculitis Induced by Laser Hair Removal: Proposed Mechanism and Treatment. 62
32802254 2020
16
Dermatologic Conditions in Transgender Populations. 62
31027550 2019
17
Laser Treatment of Skin of Color for Medical and Aesthetic Uses With a New 650-Microsecond Nd:YAG 1064nm Laser 62
31017752 2019
18
Pseudofolliculitis Barbae: A Review of Current Treatment Options 62
30909328 2019
19
Pseudofolliculitis barbae; current treatment options. 62
31354326 2019
20
Ingrown Hairs: A Recurrent Trichoscopic Feature in Scarring Alopecias. 62
30197897 2018
21
Coccidioides immitis soft tissue infection mimicking pseudofolliculitis barbae. 62
29636956 2018
22
Barber Knowledge and Recommendations Regarding Pseudofolliculitis Barbae and Acne Keloidalis Nuchae in an Urban Setting. 62
29049485 2017
23
Considerations When Treating Cosmetic Concerns in Men of Color. 62
29064976 2017
24
Acne keloidalis nuchae: risk factors and associated disorders - a retrospective study. 62
28664654 2017
25
Hair and scalp disorders in adult and pediatric patients with skin of color. 62
28873105 2017
26
Ethnic skin: Kids are not just little people. 62
27968928 2016
27
Bensal HP Attenuates the Inflammatory Response in Hair Shaving Associated Dermatitis. 62
27391633 2016
28
Pseudofolliculitis barbae: understanding the condition and the role of facial grooming. 62
27212468 2016
29
Laser and Light-Based Aesthetics in Men. 62
26355628 2015
30
Pseudofolliculitis barbae in women: a clinical perspective. 62
25557018 2015
31
Clinical, dermoscopic, and histopathologic features of body hair disorders. 62
25748313 2015
32
The diverse application of laser hair removal therapy: a tertiary laser unit's experience with less common indications and a literature overview. 62
24173910 2015
33
Ethnic hair disorders. 62
26370652 2015
34
Red face revisited: Disorders of hair growth and the pilosebaceous unit. 62
25441472 2014
35
Follicular and scarring disorders in skin of color: presentation and management. 62
24820821 2014
36
Complications related to pubic hair removal. 62
24486227 2014
37
Folliculitis keloidalis nuchae and pseudofolliculitis barbae: are prevention and effective treatment within reach? 62
24680005 2014
38
Successful treatment of recalcitrant folliculitis barbae and pseudofolliculitis barbae with photodynamic therapy. 62
24284123 2013
39
Dermatologic conditions in skin of color: part II. Disorders occurring predominately in skin of color. 62
23939568 2013
40
Pseudofolliculitis barbae: a dermatoscopic correlate. 62
23785645 2013
41
Shave frequency and regimen variation effects on the management of pseudofolliculitis barbae. 62
23652888 2013
42
Hair and scalp disorders in ethnic populations. 62
23652889 2013
43
Topical eflornithine hydrochloride improves the effectiveness of standard laser hair removal for treating pseudofolliculitis barbae: a randomized, double-blinded, placebo-controlled trial. 62
22226431 2012
44
Pseudofolliculitis barbae induced by oral minoxidil. 62
22607496 2012
45
Best practices and evidenced-based use of the 800 nm diode laser for the treatment of pseudofolliculitis barbae in skin of color. 62
22577689 2011
46
Keratin disorders: from gene to therapy. 62
21890491 2011
47
[Frizzy hair pathology]. 62
22235613 2011
48
Comparative evaluation of men's depilatory composition versus razor in black men. 62
21916277 2011
49
[Pseudofolliculitis and related disorders in skin of color]. 62
21560430 2011
50
[Pseudofolliculitis barbae]. 62
21034705 2010

Variations for Pseudofolliculitis Barbae

ClinVar genetic disease variations for Pseudofolliculitis Barbae:

5
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 KRT75 NM_004693.3(KRT75):c.481G>A (p.Ala161Thr) SNV Risk Factor
1891 rs2232387 GRCh37: 12:52827608-52827608
GRCh38: 12:52433824-52433824

Expression for Pseudofolliculitis Barbae

Search GEO for disease gene expression data for Pseudofolliculitis Barbae.

Pathways for Pseudofolliculitis Barbae

GO Terms for Pseudofolliculitis Barbae

Sources for Pseudofolliculitis Barbae

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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