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PSORS1
MCID: PSR023
MIFTS: 42
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Psoriasis 1 (PSORS1)
Categories:
Genetic diseases, Immune diseases, Rare diseases, Skin diseases
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MalaCards integrated aliases for Psoriasis 1:
Characteristics:OMIM:58
Inheritance:
multifactorial
Miscellaneous:
prevalence 1-2% in northern european populations onset bimodal, ages 16-22 and ages 57-60 inflammatory arthritis may develop in 30% of patients types of psoriasis include - plaque, guttate, erythrodermic, pustular environmental triggers include (koebner's phenomenon), sunburn, hiv infection, beta-hemolytic streptococcal infection, certain medications, stress, and alcohol HPO:33Classifications:
MalaCards categories:
Global: Genetic diseases Rare diseases Anatomical: Skin diseases Immune diseases
ICD10:
34
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OMIM
:
58
Psoriasis (psoriasis vulgaris; PV) is a chronic inflammatory dermatosis that affects approximately 2% of the population. It is characterized by red, scaly skin patches that are usually found on the scalp, elbows, and knees, and may be associated with severe arthritis. The lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. The usual age of onset of psoriasis is between 15 and 30 years, although it can present at any age (summary by Matthews et al., 1996).
Generalized pustular psoriasis (GPP) is a life-threatening disease characterized by sudden, repeated episodes of high-grade fever, generalized rash, and disseminated pustules, with hyperleukocytosis and elevated serum levels of C-reactive protein (123260) (summary by Marrakchi et al., 2011). GPP often presents in patients with existing or prior psoriasis vulgaris; however, GPP can develop without a history of PV (Sugiura et al., 2013). Palmoplantar pustulosis and acrodermatitis continua of Hallopeau represent acral forms of pustular psoriasis that have historically been grouped with GPP (summary by Setta-Kaffetzi et al., 2013).
Nestle et al. (2009) provided a detailed review of the pathogenesis and genetics of psoriasis.
(177900)
MalaCards based summary : Psoriasis 1, also known as psoriasis susceptibility 1, is related to spondylitis and psoriatic arthritis, and has symptoms including pruritus, exanthema and psoriasiform rash. An important gene associated with Psoriasis 1 is HLA-C (Major Histocompatibility Complex, Class I, C), and among its related pathways/superpathways are Human cytomegalovirus infection and Allograft rejection. Affiliated tissues include skin, and related phenotypes are arthritis and nail pits UniProtKB/Swiss-Prot : 76 Psoriasis 1: A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. |
Human phenotypes related to Psoriasis 1:33
Symptoms via clinical synopsis from OMIM:58Clinical features from OMIM:177900UMLS symptoms related to Psoriasis 1:pruritus, exanthema, psoriasiform rash GenomeRNAi Phenotypes related to Psoriasis 1 according to GeneCards Suite gene sharing:27 (show all 20)
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Inferred drug relations via UMLS 74 / NDF-RT 52 : |
MalaCards organs/tissues related to Psoriasis 1:42
Skin
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Articles related to Psoriasis 1:
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Genes related to Psoriasis 1 (1 elite genes): - Elite gene
- Cancer Census gene in COSMIC
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ClinVar genetic disease variations for Psoriasis 1:6
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Cellular components related to Psoriasis 1 according to GeneCards Suite gene sharing:
Biological processes related to Psoriasis 1 according to GeneCards Suite gene sharing:
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