Psoriasis 1

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OMIM 57 177900 MedGen 42 C1867449 MeSH 44 D011565

ICD10 33 L40.0 SNOMED-CT via HPO 69 3723001 89704006 9014002 UMLS 73 C0263361

OMIM : ⁵⁷ Psoriasis (psoriasis vulgaris; PV) is a chronic inflammatory dermatosis that affects approximately 2% of the population. It is characterized by red, scaly skin patches that are usually found on the scalp, elbows, and knees, and may be associated with severe arthritis. The lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. The usual age of onset of psoriasis is between 15 and 30 years, although it can present at any age (summary by Matthews et al., 1996). Generalized pustular psoriasis (GPP) is a life-threatening disease characterized by sudden, repeated episodes of high-grade fever, generalized rash, and disseminated pustules, with hyperleukocytosis and elevated serum levels of C-reactive protein (123260) (summary by Marrakchi et al., 2011). GPP often presents in patients with existing or prior psoriasis vulgaris; however, GPP can develop without a history of PV (Sugiura et al., 2013). Palmoplantar pustulosis and acrodermatitis continua of Hallopeau represent acral forms of pustular psoriasis that have historically been grouped with GPP (summary by Setta-Kaffetzi et al., 2013). Nestle et al. (2009) provided a detailed review of the pathogenesis and genetics of psoriasis. (177900)

MalaCards based summary : Psoriasis 1, also known as psoriasis susceptibility 1, is related to psoriasis and polycythemia vera, and has symptoms including exanthema, pruritus and psoriasiform rash. An important gene associated with Psoriasis 1 is HLA-C (Major Histocompatibility Complex, Class I, C), and among its related pathways/superpathways are Allograft rejection and Kaposi's sarcoma-associated herpesvirus infection. Affiliated tissues include skin and liver, and related phenotypes are arthritis and nail pits

UniProtKB/Swiss-Prot : ⁷⁵ Psoriasis 1: A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis.

Clinical features from OMIM:

177900

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-103	9.64	HLA-C
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-11	9.64	MICA
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-110	9.64	HLA-C
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-118	9.64	HLA-C
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-121	9.64	MICA
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-124	9.64	HLA-C
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-149	9.64	HLA-C
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-156	9.64	HLA-C
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-162	9.64	HLA-C
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-178	9.64	HLA-C
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-19	9.64	HLA-C MICA
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-202	9.64	HLA-C
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-31	9.64	HLA-C
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-46	9.64	MICA
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-47	9.64	HLA-C
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-57	9.64	MICA
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-7	9.64	HLA-C
18	Increased shRNA abundance (Z-score > 2)	GR00366-A-74	9.64	HLA-C
19	Increased shRNA abundance (Z-score > 2)	GR00366-A-83	9.64	MICA
20	Increased shRNA abundance (Z-score > 2)	GR00366-A-93	9.64	HLA-C

Search Clinical Trials , NIH Clinical Center for Psoriasis 1

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Search GEO for disease gene expression data for Psoriasis 1.