PSORS12
MCID: PSR033
MIFTS: 26

Psoriasis 12 (PSORS12)

Categories: Genetic diseases, Immune diseases, Rare diseases, Skin diseases

Aliases & Classifications for Psoriasis 12

MalaCards integrated aliases for Psoriasis 12:

Name: Psoriasis 12 57 12 15
Psoriasis Susceptibility 12 57 13
Psors12 57 12
Psoriasis 12, Susceptibility to 57

Classifications:



External Ids:

Disease Ontology 12 DOID:0111291
OMIM® 57 612950
OMIM Phenotypic Series 57 PS177900

Summaries for Psoriasis 12

Disease Ontology : 12 A psoriasis that has material basis in variation in a region on chromosome 20q13 that includes RNF114.

MalaCards based summary : Psoriasis 12, also known as psoriasis susceptibility 12, is related to pustulosis of palm and sole and psoriasis. An important gene associated with Psoriasis 12 is RNF114 (Ring Finger Protein 114), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. Affiliated tissues include skin and neutrophil, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

More information from OMIM: 612950 PS177900

Related Diseases for Psoriasis 12

Diseases in the Psoriasis family:

Psoriasis 1 Psoriasis 3
Psoriasis 2 Psoriasis 4
Psoriasis 5 Psoriasis 6
Psoriasis 7 Psoriasis 9
Psoriasis 8 Psoriasis 10
Psoriasis 11 Psoriasis 12
Psoriasis 13 Psoriasis 15

Diseases related to Psoriasis 12 via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 2, show less)
# Related Disease Score Top Affiliating Genes
1 pustulosis of palm and sole 9.8
2 psoriasis 9.8

Symptoms & Phenotypes for Psoriasis 12

Clinical features from OMIM®:

612950 (Updated 05-Apr-2021)

GenomeRNAi Phenotypes related to Psoriasis 12 according to GeneCards Suite gene sharing:

26 (showing 13, show less)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-116 9.44 IL26
2 Increased shRNA abundance (Z-score > 2) GR00366-A-144 9.44 IL26
3 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.44 IFNLR1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.44 IFNLR1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-18 9.44 IL26
6 Increased shRNA abundance (Z-score > 2) GR00366-A-187 9.44 IFNLR1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.44 IFNLR1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.44 IL26
9 Increased shRNA abundance (Z-score > 2) GR00366-A-27 9.44 IL26
10 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.44 IFNLR1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.44 IL26
12 Increased shRNA abundance (Z-score > 2) GR00366-A-55 9.44 IL26
13 Increased shRNA abundance (Z-score > 2) GR00366-A-91 9.44 IL26

Drugs & Therapeutics for Psoriasis 12

Search Clinical Trials , NIH Clinical Center for Psoriasis 12

Genetic Tests for Psoriasis 12

Anatomical Context for Psoriasis 12

MalaCards organs/tissues related to Psoriasis 12:

40
Skin, Neutrophil

Publications for Psoriasis 12

Articles related to Psoriasis 12:

(showing 28, show less)
# Title Authors PMID Year
1
Identification of rare, disease-associated variants in the promoter region of the RNF114 psoriasis susceptibility gene. 57
22205304 2012
2
Identification of ZNF313/RNF114 as a novel psoriasis susceptibility gene. 57
18364390 2008
3
A head-to-head comparison of ixekizumab vs. guselkumab in patients with moderate-to-severe plaque psoriasis: 12-week efficacy, safety and speed of response from a randomized, double-blinded trial. 61
31887225 2020
4
Evaluation of Children with Psoriasis from the BiPe Cohort: Are Patients Using Biotherapies in Real Life Eligible for Phase III Clinical Studies? 61
31155692 2019
5
High dose hepatitis B vaccine is not effective in patients using immunomodulatory drugs: a pilot study. 61
30676860 2019
6
Differentiation of pityriasis rubra pilaris from plaque psoriasis by dermoscopy. 61
30479860 2018
7
Generalized Pustular Psoriasis (Von Zumbusch Type) Following Renal Transplant: A Case Report. 61
27915962 2018
8
The efficacy and safety of phototherapy in geriatric patients: a retrospective study. 61
33272485 2018
9
The efficacy and safety of phototherapy in geriatric patients: a retrospective study. 61
29641694 2018
10
Evaluation of Anti-Cyclic Citrullinated Peptide Autoantibodies and C-Reactive Protein in Common Autoimmune Skin Diseases with and without Arthritis. 61
28892879 2017
11
Dermoscopy of nail fold and elbow in the differential diagnosis of early psoriatic arthritis sine psoriasis and early rheumatoid arthritis. 61
27237922 2016
12
Lack of association of ALOX12 and ALOX15B polymorphisms with psoriasis despite altered urinary excretion of 12(S)-hydroxyeicosatetraenoic acid. 61
24975552 2015
13
A systematic literature review to compare quality of life in psoriasis with other chronic diseases using EQ-5D-derived utility values. 61
26185476 2015
14
Rituximab treatment for spondyloarthritis. A nationwide series: data from the AIR registry of the French Society of Rheumatology. 61
22896028 2012
15
A subset of methylated CpG sites differentiate psoriatic from normal skin. 61
22071477 2012
16
Different applications of monochromatic excimer light in skin diseases. 61
19563242 2009
17
Comparison of expression of heat-shock protein 60, Toll-like receptors 2 and 4, and T-cell receptor gammadelta in plaque and guttate psoriasis. 61
18001412 2007
18
Clinical and genetic aspects of psoriatic arthritis "sine psoriasis". 61
14719207 2003
19
SCH 47112, a novel staurosporine derivative, inhibits 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and epidermal hyperplasia in hairless mouse skin. 61
9341975 1997
20
[Cyclosporin A in the therapy of inflammatory dermatoses]. 61
1468930 1992
21
Successful treatment of chronic skin diseases with clobetasol propionate and a hydrocolloid occlusive dressing. 61
1350154 1992
22
[Fumaric acid therapy in psoriasis; a double-blind, placebo-controlled study]. 61
2263264 1990
23
Intradermal antigen tests in psoriasis. 61
1972847 1990
24
SC-41930 inhibits neutrophil infiltration of the cavine dermis induced by 12(R)-hydroxyeicosatetraenoic acid. 61
2560200 1989
25
12(R)-hydroxyeicosatetraenoic acid is a neutrophil chemoattractant in the cavine, lapine, murine and canine dermis. 61
2550970 1989
26
[Analysis of circulating T-lymphocyte subpopulations with monoclonal antibodies in psoriasis]. 61
3526042 1986
27
Fructose-induced hyperuricemia in psoriasis and psoriatic arthritis. 61
6681134 1983
28
HL-A antigens in psoriasis with special reference to the clinical type, age of onset, exacerbations after respiratory infections and occurrence of arthritis. 61
1211846 1975

Variations for Psoriasis 12

Expression for Psoriasis 12

Search GEO for disease gene expression data for Psoriasis 12.

Pathways for Psoriasis 12

Pathways related to Psoriasis 12 according to GeneCards Suite gene sharing:

(showing 5, show less)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.33 RNF114 IL19 IFNLR1 IFNL2 IFNL1 ICOSLG
2
Show member pathways
12.89 IL26 IL19 IFNLR1 IFNL2 IFNL1
3
Show member pathways
12.73 IL19 IFNLR1 IFNL2 IFNL1
4
Show member pathways
11.32 IL19 IFNLR1 IFNL2 IFNL1
5 10.63 IFNL2 IFNL1

GO Terms for Psoriasis 12

Cellular components related to Psoriasis 12 according to GeneCards Suite gene sharing:

(showing 1, show less)
# Name GO ID Score Top Affiliating Genes
1 interleukin-28 receptor complex GO:0032002 8.62 IFNLR1 IFNL1

Biological processes related to Psoriasis 12 according to GeneCards Suite gene sharing:

(showing 6, show less)
# Name GO ID Score Top Affiliating Genes
1 defense response to virus GO:0051607 9.43 IFNLR1 IFNL2 IFNL1
2 positive regulation of JAK-STAT cascade GO:0046427 9.37 IL26 IFNL1
3 JAK-STAT cascade GO:0007259 9.32 IFNL2 IFNL1
4 positive regulation of immune response GO:0050778 9.16 IFNL2 IFNL1
5 cytokine-mediated signaling pathway GO:0019221 9.02 IL26 IL19 IFNLR1 IFNL2 IFNL1
6 mucosal immune response GO:0002385 8.96 IFNLR1 IFNL2

Molecular functions related to Psoriasis 12 according to GeneCards Suite gene sharing:

(showing 2, show less)
# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.13 IFNL2 IFNL1 ICOSLG
2 cytokine activity GO:0005125 8.92 IL26 IL19 IFNL2 IFNL1

Sources for Psoriasis 12

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....