PSORS13
MCID: PSR018
MIFTS: 45

Psoriasis 13 (PSORS13)

Categories: Genetic diseases, Immune diseases, Rare diseases, Skin diseases

Aliases & Classifications for Psoriasis 13

MalaCards integrated aliases for Psoriasis 13:

Name: Psoriasis 13 57 75
Psoriasis Susceptibility 13 57 29 13 6
Psoriasis Vulgaris 75 73
Psoriasis 75 73
Psors13 57 75
Psoriasis, Susceptibility to, Type 13 40
Psoriasis 13, Susceptibility to 57
Pv 75

Classifications:



External Ids:

OMIM 57 614070
MedGen 42 C3279754
MeSH 44 D011565

Summaries for Psoriasis 13

UniProtKB/Swiss-Prot : 75 Psoriasis 13: A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis.

MalaCards based summary : Psoriasis 13, also known as psoriasis susceptibility 13, is related to psoriasis and guttate psoriasis, and has symptoms including pruritus, exanthema and psoriasiform rash. An important gene associated with Psoriasis 13 is TRAF3IP2 (TRAF3 Interacting Protein 2). Affiliated tissues include skin, testes and t cells.

Description from OMIM: 614070

Related Diseases for Psoriasis 13

Diseases in the Psoriasis family:

Psoriasis 1 Psoriasis 3
Psoriasis 2 Psoriasis 4
Psoriasis 5 Psoriasis 6
Psoriasis 7 Psoriasis 9
Psoriasis 8 Psoriasis 10
Psoriasis 11 Psoriasis 12
Psoriasis 13

Diseases related to Psoriasis 13 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 664)
# Related Disease Score Top Affiliating Genes
1 psoriasis 13.0
2 guttate psoriasis 12.6
3 pustular psoriasis 12.5
4 polycythemia vera 12.3
5 psoriasis 15, pustular 12.3
6 psoriatic arthritis 12.3
7 pustulosis palmaris et plantaris 12.2
8 psoriasis 6 12.2
9 psoriasis 3 12.1
10 psoriasis 4 12.1
11 psoriasis 5 12.1
12 psoriasis 8 12.1
13 psoriasis 10 12.1
14 psoriasis 12 12.1
15 mental retardation and psoriasis 12.0
16 psoriasis 9 12.0
17 pustulosis of palm and sole 11.9
18 psoriatic juvenile idiopathic arthritis 11.9
19 tranebjaerg svejgaard syndrome 11.7
20 psoriasis 1 11.7
21 impetigo herpetiformis 11.6
22 pulmonary valve stenosis 11.5
23 arthritis 11.5
24 geographic tongue 11.4
25 parapsoriasis 11.4
26 pemphigus vulgaris, familial 11.4
27 persistent vegetative state 11.4
28 chronic recurrent multifocal osteomyelitis 11.3
29 subacute cutaneous lupus erythematosus 11.3
30 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 11.3
31 psoriasis 14, pustular 11.2
32 singleton-merten syndrome 1 11.1
33 systemic onset juvenile idiopathic arthritis 11.1
34 porphyria variegata 11.0
35 psoriasis 2 11.0
36 psoriasis 7 11.0
37 psoriasis 11 11.0
38 nail disorder, nonsyndromic congenital, 1 10.9
39 singleton-merten syndrome 2 10.9
40 temporomandibular ankylosis 10.9
41 primary cutaneous amyloidosis 10.9
42 combined immunodeficiency with skin granulomas 10.9
43 singleton-merten syndrome 10.9
44 dermatitis 10.7
45 dermatitis, atopic 10.5
46 polycythemia 10.4
47 rheumatoid arthritis 10.4
48 skin disease 10.3
49 malaria 10.3
50 pemphigus foliaceus 10.3

Graphical network of the top 20 diseases related to Psoriasis 13:



Diseases related to Psoriasis 13

Symptoms & Phenotypes for Psoriasis 13

Clinical features from OMIM:

614070

UMLS symptoms related to Psoriasis 13:


pruritus, exanthema, psoriasiform rash

Genetic Tests for Psoriasis 13

Genetic tests related to Psoriasis 13:

# Genetic test Affiliating Genes
1 Psoriasis Susceptibility 13 29 TRAF3IP2

Anatomical Context for Psoriasis 13

MalaCards organs/tissues related to Psoriasis 13:

41
Skin, Testes, T Cells, Liver, Thyroid, Bone, Tongue

Publications for Psoriasis 13

Articles related to Psoriasis 13:

(show top 50) (show all 979)
# Title Authors Year
1
A Chinese cross-sectional study on depression and anxiety symptoms in patients with psoriasis vulgaris. ( 30293440 )
2019
2
Psoriasis vulgaris in a patient with pemphigus vulgaris on corticosteroid therapy. ( 29689136 )
2018
3
Relationship between etanercept and thyroid function in patients with psoriasis vulgaris. ( 29440950 )
2018
4
Auftreten einer Psoriasis vulgaris bei einem Patienten mit Pemphigus vulgaris unter Kortikosteroidtherapie. ( 29750447 )
2018
5
Concurrent development of psoriatic arthritis, drug-induced interstitial pneumonia, and increased anti-nuclear antibodies in a patient with psoriasis vulgaris undergoing adalimumab treatment. ( 30530442 )
2018
6
Metabolic syndrome and psoriatic arthritis among patients with psoriasis vulgaris: Quality of life and prevalence. ( 30474868 )
2018
7
Differences in Palmoplantar Pustulosis and Psoriasis Vulgaris in Patients with Rheumatoid Arthritis or Ankylosing Spondylitis Treated with Biological Therapy. ( 30323005 )
2018
8
De Novo Psoriasis Vulgaris Diagnosed after Nivolumab Treatment for Refractory Hodgkin's Lymphoma, Completely Resolved after Autologous Hematopoietic Stem Cell Transplantation. ( 30410803 )
2018
9
Psoriasis vulgaris associated with systemic lupus erythematosus successfully treated with apremilast. ( 30536461 )
2018
10
Pemphigus Associated with Psoriasis Vulgaris: A Retrospective Study of Seven Patients and a Review of the Literature. ( 30390724 )
2018
11
Paradoxical exacerbation of latent interstitial pneumonia by secukinumab in a patient with psoriasis vulgaris. ( 30430554 )
2018
12
Serum Levels of Aryl Hydrocarbon Receptor, Cytochromes P450 1A1 and 1B1 in Patients with Exacerbated Psoriasis Vulgaris. ( 30394267 )
2018
13
Hochregulation der SLURP1-Immunfärbung in Läsionen von Psoriasis-vulgaris-Patienten entspricht dem Schweregrad der Erkrankung. ( 30395397 )
2018
14
Lesional upregulation of SLURP1 immunostaining parallels disease severity in psoriasis vulgaris patients. ( 30395407 )
2018
15
Serum YKL-40 in patients with psoriasis vulgaris treated by narrow-band UVB phototherapy. ( 30482111 )
2018
16
Association of ERAP1 gene polymorphisms with the susceptibility to psoriasis vulgaris: A case-control study. ( 30313118 )
2018
17
Expression of death receptor 3 (DR3) on peripheral blood mononuclear cells of patients with psoriasis vulgaris. ( 30341229 )
2018
18
Calcipotriol/betamethasone dipropionate aerosol foam for the treatment of psoriasis vulgaris: case series and review of the literature. ( 30349342 )
2018
19
Clinical and molecular evaluation of therapy with the use of cyclosporine A in patients with psoriasis vulgaris. ( 30350412 )
2018
20
Variants of CARD14 are predisposing factors for generalized pustular psoriasis (GPP) with psoriasis vulgaris but not for GPP alone in a Chinese population. ( 30387497 )
2018
21
Transforming growth factor-β1 gene polymorphism in psoriasis vulgaris. ( 30174452 )
2018
22
Psoriasis Vulgaris Exacerbation during Treatment with a PD-1 Checkpoint Inhibitor: Case Report and Literature Review. ( 30186132 )
2018
23
Mean platelet volume and platelet distribution width levels in patients with mild psoriasis vulgaris with metabolic syndrome. ( 30206448 )
2018
24
Treatment of psoriasis vulgaris using low-dose naltrexone. ( 30238048 )
2018
25
Efficacy, safety, and cost-effectiveness of all-trans retinoic acid/Clobetasol Propionate Compound Ointment in the treatment of mild to moderate psoriasis vulgaris: A randomized, single-blind, multicenter clinical trial. ( 30253049 )
2018
26
Evaluation of capillary pathologies by nailfold capillaroscopy in patients with psoriasis vulgaris: study protocol for a prospective, controlled exploratory study. ( 30099394 )
2018
27
Evaluation of epicardial adipose tissue volume and coronary artery calcification in Japanese patients with psoriasis vulgaris. ( 30152023 )
2018
28
Concurrence of psoriasis vulgaris and atopic eczema in a single patient exhibiting different expression patterns of psoriatic autoantigens in the lesional skin. ( 29984272 )
2018
29
NAT2 Gene Polymorphisms in Turkish Patients with Psoriasis Vulgaris. ( 29992137 )
2018
30
Metabolic Syndrome May Exacerbate Macular and Retinal Damage in Psoriasis Vulgaris. ( 29847216 )
2018
31
Efficacy and Safety of Tripterygium Wilfordii Hook F on Psoriasis Vulgaris: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. ( 29849698 )
2018
32
Association of NLRP1 and NLRP3 Polymorphisms with Psoriasis Vulgaris Risk in the Chinese Han Population. ( 29850521 )
2018
33
Association of Cytotoxic T Lymphocyte Antigen-4 Gene Polymorphisms with Psoriasis Vulgaris: A Case-Control Study in Turkish Population. ( 29850619 )
2018
34
Effect of low-dose acitretin treatment on pituitary hormones in psoriasis vulgaris: A retrospective study. ( 29855455 )
2018
35
S3-Leitlinie zur Therapie der Psoriasis vulgaris Update - Kurzfassung Teil 2 - Besondere Patientengruppen und spezielle Behandlungssituationen. ( 29873903 )
2018
36
S3 Guideline for the treatment of psoriasis vulgaris, update - Short version part 2 - Special patient populations and treatment situations. ( 29873906 )
2018
37
Density of mast cells and intensity of pruritus in psoriasis vulgaris: a cross sectional study. ( 29924253 )
2018
38
Methods Report: Update of the German S3 Guideline for the Treatment of Psoriasis vulgaris. ( 29750442 )
2018
39
S3 Guideline for the treatment of psoriasis vulgaris, update - Short version part 1 - Systemic treatment. ( 29750443 )
2018
40
S3-Leitlinie zur Therapie der Psoriasis vulgaris Update - Kurzfassung Teil 1 - Systemische Therapie. ( 29750455 )
2018
41
Evaluating Serum Levels of IL-33, IL-36, IL-37 and Gene Expression of IL-37 in Patients with Psoriasis Vulgaris. ( 29757591 )
2018
42
Mutational analysis of epidermal and hyperproliferative type I keratins in mild and moderate psoriasis vulgaris patients: a possible role in the pathogenesis of psoriasis along with disease severity. ( 29784039 )
2018
43
A case of anti-laminin γ1 (p200) pemphigoid with psoriasis vulgaris successfully treated with apremilast. ( 29619999 )
2018
44
Association of the novel susceptible locus rs9266150 with clinical features of psoriasis vulgaris in the Chinese Han population. ( 29630754 )
2018
45
Notch1 Signaling Regulates the Th17/Treg Immune Imbalance in Patients with Psoriasis Vulgaris. ( 29686529 )
2018
46
A case of refractory lupus nephritis complicated by psoriasis vulgaris that was controlled with secukinumab. ( 29523055 )
2018
47
Variants at HLA-A, HLA-C, and HLA-DQB1 Confer Risk of Psoriasis Vulgaris in Japanese. ( 29031612 )
2018
48
Low incidence of hypercalcemia following combined calcipotriol hydrate/betamethasone dipropionate ointment treatment in Japanese patients with severe psoriasis vulgaris. ( 29076379 )
2018
49
The association of ERAP1 and ERAP2 single nucleotide polymorphisms and their haplotypes with psoriasis vulgaris is dependent on the presence or absence of the HLA-C*06:02 allele and age at disease onset. ( 29183862 )
2018
50
Integrative Approach to Psoriasis Vulgaris. ( 29261515 )
2018

Variations for Psoriasis 13

UniProtKB/Swiss-Prot genetic disease variations for Psoriasis 13:

75
# Symbol AA change Variation ID SNP ID
1 TRAF3IP2 p.Asp19Asn VAR_047349 rs33980500

ClinVar genetic disease variations for Psoriasis 13:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 TRAF3IP2 NM_147686.3(TRAF3IP2): c.28G> A (p.Asp10Asn) single nucleotide variant Benign rs33980500 GRCh37 Chromosome 6, 111913262: 111913262
2 TRAF3IP2 NM_147686.3(TRAF3IP2): c.28G> A (p.Asp10Asn) single nucleotide variant Benign rs33980500 GRCh38 Chromosome 6, 111592059: 111592059

Expression for Psoriasis 13

Search GEO for disease gene expression data for Psoriasis 13.

Pathways for Psoriasis 13

GO Terms for Psoriasis 13

Sources for Psoriasis 13

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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