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MCID: PSR034
MIFTS: 29

Psoriasis 15

Categories: Genetic diseases, Immune diseases, Rare diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Psoriasis 15

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MalaCards integrated aliases for Psoriasis 15:

Name: Psoriasis 15 12 15
Psors15 12

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Immune diseases Skin diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0111281
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Summaries for Psoriasis 15

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Disease Ontology : 12 A psoriasis characterized by pustular psoriasis that has material basis in heterozygous mutation in AP1S3 on chromosome 2q36.1.

MalaCards based summary : Psoriasis 15, also known as psors15, is related to pustulosis of palm and sole and psoriasis. An important gene associated with Psoriasis 15 is AP1S3 (Adaptor Related Protein Complex 1 Subunit Sigma 3), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Affiliated tissues include skin and t cells.

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Related Diseases for Psoriasis 15

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Diseases in the Psoriasis family:

Psoriasis 1 Psoriasis 3
Psoriasis 2 Psoriasis 4
Psoriasis 5 Psoriasis 6
Psoriasis 7 Psoriasis 9
Psoriasis 8 Psoriasis 10
Psoriasis 11 Psoriasis 12
Psoriasis 13 Psoriasis 15

Diseases related to Psoriasis 15 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 172)
# Related Disease Score Top Affiliating Genes
1 pustulosis of palm and sole 29.6 IL17A AP1S3
2 psoriasis 28.4 IL4 IL31 IL17F IL17A IL13 ELANE
3 psoriasis 15, pustular 11.6
4 chronic inducible urticaria 10.3 TSLP IL31
5 combined oxidative phosphorylation deficiency 16 10.3 EPHA4 CUL3 AP1S3
6 prurigo nodularis 10.3 TAC1 IL17A
7 tinea corporis 10.3 IL31 DEFB4A
8 chronic asthma 10.3 IL4 IL13
9 metal allergy 10.3 IL4 IL17A
10 irritant dermatitis 10.2 TSLP IL4 IL31
11 loiasis 10.2 IL4 IL13
12 mikulicz disease 10.2 IL4 IL13
13 urticaria 10.2 IL4 IL31 IL13
14 nut allergy 10.2 IL4 IL13
15 pemphigoid 10.2 IL4 IL13
16 predominantly cortical thymoma 10.2 CD1E CD1A
17 egg allergy 10.2 TSLP IL4 IL13
18 cystitis 10.2 TAC1 IL4 IL17A
19 legume allergy 10.2 TSLP IL4 IL13
20 fruit allergy 10.2 TSLP IL4 IL13
21 tolosa-hunt syndrome 10.2 CD1E CD1A
22 chronic conjunctivitis 10.2 TSLP IL4 IL13
23 osteonecrosis of the jaw 10.2 IL17A DEFB4A
24 chronic rhinitis 10.2 TAC1 IL4 IL13
25 esophagitis, eosinophilic, 1 10.2 TSLP IL4 IL13
26 esophagitis 10.2 TSLP IL4 IL13
27 chromium allergic contact dermatitis 10.2 IL4 IL17A IL13
28 dermatitis herpetiformis 10.2 IL4 IL31 IL17A
29 dendritic cell thymoma 10.2 CD1E CD1A
30 severe combined immunodeficiency, x-linked 10.2 TSLP IL4 IL13
31 acute generalized exanthematous pustulosis 10.2 IL17F IL17A
32 timothy grass allergy 10.2 IL4 IL17A IL13
33 dacryoadenitis 10.2 IL4 IL17A IL13
34 fungal meningitis 10.2 IL4 IL17A IL13
35 meningitis 10.2 IL4 IL17A IL13
36 radiculopathy 10.2 TAC1 IL17A IL13
37 multifocal motor neuropathy 10.2 CD1E CD1A
38 intestinal schistosomiasis 10.2 IL4 IL17A IL13
39 schistosomiasis 10.2 IL4 IL17A IL13
40 drug-induced lupus erythematosus 10.2 IL4 IL17A IL13
41 cryptococcosis 10.2 IL4 IL17A IL13
42 mycoplasma pneumoniae pneumonia 10.2 IL4 IL17A IL13
43 paranasal sinus disease 10.1 IL4 IL17A IL13
44 oral hairy leukoplakia 10.1 CD1E CD1A
45 brucellosis 10.1 IL4 IL17A IL13
46 cutaneous leishmaniasis 10.1 IL4 IL17A IL13
47 leishmaniasis 10.1 IL4 IL17A IL13
48 bronchiolitis 10.1 IL4 IL17A IL13
49 food allergy 10.1 IL4 IL17A IL13
50 parasitic protozoa infectious disease 10.1 IL4 IL17A IL13

Graphical network of the top 20 diseases related to Psoriasis 15:



Diseases related to Psoriasis 15
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Symptoms & Phenotypes for Psoriasis 15

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Drugs & Therapeutics for Psoriasis 15

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Search Clinical Trials , NIH Clinical Center for Psoriasis 15

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Genetic Tests for Psoriasis 15

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Anatomical Context for Psoriasis 15

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MalaCards organs/tissues related to Psoriasis 15:

40
Skin, T Cells
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Publications for Psoriasis 15

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Articles related to Psoriasis 15:

(show all 18)
# Title Authors PMID Year
1
Histone Deacetylase 1 and Sirtuin 1 Expression in Psoriatic Skin: A Comparison between Guttate and Plaque Psoriasis. 61
32825671 2020
2
Increased frequency of activated CD8+ T cell effectors in patients with psoriatic arthritis. 61
31350460 2019
3
Current pharmaceutical developments in atopic dermatitis. 61
30611103 2019
4
Depressiveness, measured with Beck Depression Inventory, in patients with psoriasis. 61
27930916 2017
5
A Novel Aerosol Foam Formulation of Calcipotriol and Betamethasone Has No Impact on HPA Axis and Calcium Homeostasis in Patients With Extensive Psoriasis Vulgaris. 61
26224733 2016
6
A prospective study on the use of teledermatology in psychiatric patients with chronic skin diseases. 61
25754857 2015
7
Are all patients with psoriasis at increased risk for coronary artery disease? 61
25428719 2015
8
Etanercept downregulates the Th17 pathway and decreases the IL-17+/IL-10+ cell ratio in patients with psoriasis vulgaris. 61
22699761 2012
9
[Species of Malassezia associated with various dermatoses and healthy skin in the Mexican population]. 61
15456351 2003
10
Expression of dipeptidyl-peptidase IV (CD26) on CD8+ T cells is significantly decreased in patients with psoriasis vulgaris and atopic dermatitis. 61
11737260 2001
11
Vulvar disease in children: a clinical audit of 130 cases. 61
10720979 2000
12
Simple chemiluminescence assays for free radicals in venous blood and serum samples: results in atopic, psoriasis, MCS and cancer patients. 61
10649000 1999
13
Combination treatment with methotrexate and cyclosporin for severe recalcitrant psoriasis. 61
10468800 1999
14
SKALP/elafin gene polymorphisms are not associated with pustular forms of psoriasis. 61
9727750 1998
15
[Monitoring of sE-selectin serum levels in three different dermatoses]. 61
9621489 1998
16
Photosensitizing compounds in the treatment of psoriasis. 61
2697531 1989
17
Eicosanoids in psoriasis--15-HETE on the stage. 61
3108043 1987
18
HL-A antigens in patients with persistent palmoplantar pustulosis and pustular psoriasis. 61
1181975 1975
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Variations for Psoriasis 15

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Expression for Psoriasis 15

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Search GEO for disease gene expression data for Psoriasis 15.
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Pathways for Psoriasis 15

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Pathways related to Psoriasis 15 according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.69 MRC1 IL4 IL31 IL17F IL17A IL13
2
Class I MHC mediated antigen processing and presentation 65
Show member pathways
 13.26 MRC1 CUL3 CD1D CD1C CD1B CD1A
3
IL-17 Family Signaling Pathways 64
Show member pathways
 12.17 IL4 IL17F IL17A IL13 DEFB4A
4
Tight junction 36
11.95 CD1E CD1D CD1C CD1B CD1A
5
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 65
11.91 CD1D CD1C CD1B CD1A
6
Interleukin-4 and 13 signaling 65
11.81 IL4 IL17F IL17A IL13
7
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.79 IL4 CD83 CD1C
8
Th17 Differentiation Pathway 64
Show member pathways
 11.66 IL4 IL17F IL17A
9
Innate Lymphoid Cell Differentiation Pathways 64
11.61 TSLP IL4 IL17A IL13
10
Amoebiasis 36
11.56 CD1E CD1D CD1C CD1B CD1A
11
Dendritic Cells Developmental Lineage Pathway 64
11.54 CD83 CD1D CD1C CD1A
12
Th2 Differentiation Pathway 64
11.33 IL4 IL31 IL13
13
Hematopoietic cell lineage 36
11.1 IL4 CD1E CD1D CD1C CD1B CD1A
14
Development and heterogeneity of the ILC family 1
10.76 TSLP IL4 IL17A IL13
15
IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types 64
10.59 IL4 IL13
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GO Terms for Psoriasis 15

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Cellular components related to Psoriasis 15 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.02 TSLP TAC1 IL4 IL31 IL17F IL17A
2 integral component of plasma membrane GO:0005887 9.95 MRC1 EPHA4 CD83 CD1E CD1D CD1C
3 cell surface GO:0009986 9.83 MRC1 EPHA4 ELANE CD1D CD1B
4 lysosome GO:0005764 9.72 LAMP3 CD1E CD1D CD1C CD1B
5 endosome GO:0005768 9.7 MRC1 EPHA4 CD1E CD1D CD1C CD1B
6 endosome membrane GO:0010008 9.65 MRC1 CD1D CD1C CD1B CD1A
7 external side of plasma membrane GO:0009897 9.56 IL17A IL13 CD83 CD1E CD1D CD1C
8 extracellular space GO:0005615 9.47 TSLP TAC1 IL4 IL31 IL17F IL17A

Biological processes related to Psoriasis 15 according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.97 LAMP3 IL31 IL17F IL17A CD1E CD1D
2 adaptive immune response GO:0002250 9.95 LAMP3 IL17F IL17A CD1E CD1C CD1B
3 cytokine-mediated signaling pathway GO:0019221 9.92 IL4 IL31 IL17F IL17A IL13
4 immune response GO:0006955 9.91 IL4 IL17A IL13 DEFB4A CD1E CD1D
5 regulation of immune response GO:0050776 9.83 IL4 CD1D CD1C CD1B CD1A
6 defense response to Gram-positive bacterium GO:0050830 9.77 IL17F IL17A DEFB4A
7 positive regulation of interleukin-6 production GO:0032755 9.76 TSLP IL17F IL17A
8 defense response to Gram-negative bacterium GO:0050829 9.76 TSLP IL17F IL17A DEFB4A
9 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.74 TSLP IL4 IL13
10 defense response to fungus GO:0050832 9.67 TSLP IL17A ELANE
11 positive regulation of interleukin-10 production GO:0032733 9.67 TSLP IL4 IL13 CD83
12 macrophage activation GO:0042116 9.59 IL4 IL13
13 positive regulation of interleukin-13 production GO:0032736 9.58 TSLP IL4
14 interleukin-17-mediated signaling pathway GO:0097400 9.56 IL17F IL17A
15 positive regulation of mast cell degranulation GO:0043306 9.55 IL4 IL13
16 positive regulation of T cell mediated cytotoxicity GO:0001916 9.55 CD1E CD1D CD1C CD1B CD1A
17 positive regulation of chemokine (C-X-C motif) ligand 1 production GO:2000340 9.54 IL17F IL17A
18 negative regulation of complement-dependent cytotoxicity GO:1903660 9.51 IL4 IL13
19 positive regulation of antimicrobial peptide production GO:0002225 9.48 IL17F IL17A
20 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 9.35 CD1E CD1D CD1C CD1B CD1A
21 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 9.02 CD1E CD1D CD1C CD1B CD1A

Molecular functions related to Psoriasis 15 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.8 TSLP IL4 IL31 IL17F IL17A IL13
2 cytokine receptor binding GO:0005126 9.56 IL4 IL31 IL17F IL13
3 lipopeptide binding GO:0071723 9.55 CD1E CD1D CD1C CD1B CD1A
4 exogenous lipid antigen binding GO:0030884 9.35 CD1E CD1D CD1C CD1B CD1A
5 endogenous lipid antigen binding GO:0030883 9.02 CD1E CD1D CD1C CD1B CD1A
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Sources for Psoriasis 15

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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