MCID: PSR034
MIFTS: 27

Psoriasis 15

Categories: Genetic diseases, Immune diseases, Rare diseases, Skin diseases

Aliases & Classifications for Psoriasis 15

MalaCards integrated aliases for Psoriasis 15:

Name: Psoriasis 15 12 15
Psors15 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0111281

Summaries for Psoriasis 15

Disease Ontology : 12 A psoriasis characterized by pustular psoriasis that has material basis in heterozygous mutation in AP1S3 on chromosome 2q36.1.

MalaCards based summary : Psoriasis 15, also known as psors15, is related to pustulosis of palm and sole and psoriasis. An important gene associated with Psoriasis 15 is AP1S3 (Adaptor Related Protein Complex 1 Subunit Sigma 3), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. Affiliated tissues include skin and t cells.

Related Diseases for Psoriasis 15

Diseases in the Psoriasis family:

Psoriasis 1 Psoriasis 3
Psoriasis 2 Psoriasis 4
Psoriasis 5 Psoriasis 6
Psoriasis 7 Psoriasis 9
Psoriasis 8 Psoriasis 10
Psoriasis 11 Psoriasis 12
Psoriasis 13 Psoriasis 15

Diseases related to Psoriasis 15 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Related Disease Score Top Affiliating Genes
1 pustulosis of palm and sole 30.0 IL17A AP1S3
2 psoriasis 28.5 IL31 IL17F IL17A ELANE DEFB4A AP1S3
3 psoriasis 15, pustular 12.7
4 tinea corporis 10.3 IL31 DEFB4A
5 osteonecrosis of the jaw 10.3 IL17A DEFB4A
6 verruciform xanthoma of skin 10.2 CD1E CD1A
7 chronic laryngitis 10.2 CD1E CD1A
8 acute generalized exanthematous pustulosis 10.2 IL17F IL17A
9 nose disease 10.2 TSLP TAC1 IL17A
10 multifocal motor neuropathy 10.2 CD1E CD1A
11 necrobiosis lipoidica 10.2 CD1E CD1A
12 irritant dermatitis 10.2 TSLP IL31
13 klebsiella pneumonia 10.1 IL17F IL17A
14 cutaneous candidiasis 10.1 IL17F IL17A
15 lichen planus 10.1 IL17A DEFB4A CD1A
16 nasal cavity disease 10.1 TSLP TAC1 IL31 IL17A
17 pityriasis rosea 10.1 CD1E CD1A
18 oral candidiasis 10.1 IL17F IL17A DEFB4A
19 candidiasis 10.0 IL17F IL17A DEFB4A
20 skin sarcoidosis 10.0 CD83 CD1E CD1B
21 pustular psoriasis 10.0 ELANE AP1S3
22 impetigo herpetiformis 10.0 ELANE AP1S3
23 allergic hypersensitivity disease 9.9 TSLP TAC1 IL17A
24 epithelial malignant thymoma 9.9 CD1E CD1B CD1A
25 dendritic cell thymoma 9.9 CD1E CD1B CD1A
26 acanthoma 9.9 CD1E CD1B CD1A
27 allergic contact dermatitis 9.9 IL31 IL17F IL17A DEFB4A
28 integumentary system disease 9.9 TSLP IL31 IL17F IL17A
29 granulomatous dermatitis 9.9 CD1C CD1B
30 histiocytosis 9.9 IL17A CD1C CD1A
31 hyper ige recurrent infection syndrome 1 9.8 IL17F IL17A
32 pustulosis palmaris et plantaris 9.8 ELANE AP1S3
33 folliculitis 9.8 DEFB4A CD1E CD1B CD1A
34 combined oxidative phosphorylation deficiency 16 9.8 STAT5B EPHA4 EPHA1 CUL3 AP1S3
35 langerhans cell histiocytosis 9.8 IL17A CD1C CD1A
36 gingival disease 9.8 IL17A ELANE DEFB4A
37 bacterial pneumonia 9.7 IL17A ELANE DEFB4A
38 chronic mucocutaneous candidiasis 9.7 STAT5B IL17F IL17A
39 periodontitis 9.7 IL17A ELANE DEFB4A
40 dermatitis, atopic 9.7 TSLP TAC1 IL31 IL17A DEFB4A CD83
41 bronchial disease 9.6 TSLP TAC1 IL17A ELANE
42 malignant histiocytic disease 9.5 CD1E CD1C CD1B CD1A
43 mycobacterium malmoense 9.5 CD1E CD1C CD1B CD1A
44 encapsulated thymoma 9.5 CD1E CD1C CD1B CD1A
45 central nervous system sarcoma 9.5 CD1E CD1C CD1B CD1A
46 lichen nitidus 9.5 CD1E CD1C CD1B CD1A
47 rhinoscleroma 9.5 CD1E CD1C CD1B CD1A
48 reticulohistiocytic granuloma 9.5 CD1E CD1C CD1B CD1A
49 interdigitating dendritic cell sarcoma 9.5 CD1E CD1C CD1B CD1A
50 langerhans cell sarcoma 9.5 CD1E CD1C CD1B CD1A

Graphical network of the top 20 diseases related to Psoriasis 15:



Diseases related to Psoriasis 15

Symptoms & Phenotypes for Psoriasis 15

Drugs & Therapeutics for Psoriasis 15

Search Clinical Trials , NIH Clinical Center for Psoriasis 15

Genetic Tests for Psoriasis 15

Anatomical Context for Psoriasis 15

MalaCards organs/tissues related to Psoriasis 15:

40
Skin, T Cells

Publications for Psoriasis 15

Articles related to Psoriasis 15:

(show all 17)
# Title Authors PMID Year
1
Increased frequency of activated CD8+ T cell effectors in patients with psoriatic arthritis. 61
31350460 2019
2
Current pharmaceutical developments in atopic dermatitis. 61
30611103 2019
3
Depressiveness, measured with Beck Depression Inventory, in patients with psoriasis. 61
27930916 2017
4
A Novel Aerosol Foam Formulation of Calcipotriol and Betamethasone Has No Impact on HPA Axis and Calcium Homeostasis in Patients With Extensive Psoriasis Vulgaris. 61
26224733 2016
5
A prospective study on the use of teledermatology in psychiatric patients with chronic skin diseases. 61
25754857 2015
6
Are all patients with psoriasis at increased risk for coronary artery disease? 61
25428719 2015
7
Etanercept downregulates the Th17 pathway and decreases the IL-17+/IL-10+ cell ratio in patients with psoriasis vulgaris. 61
22699761 2012
8
[Species of Malassezia associated with various dermatoses and healthy skin in the Mexican population]. 61
15456351 2003
9
Expression of dipeptidyl-peptidase IV (CD26) on CD8+ T cells is significantly decreased in patients with psoriasis vulgaris and atopic dermatitis. 61
11737260 2001
10
Vulvar disease in children: a clinical audit of 130 cases. 61
10720979 2000
11
Simple chemiluminescence assays for free radicals in venous blood and serum samples: results in atopic, psoriasis, MCS and cancer patients. 61
10649000 1999
12
Combination treatment with methotrexate and cyclosporin for severe recalcitrant psoriasis. 61
10468800 1999
13
SKALP/elafin gene polymorphisms are not associated with pustular forms of psoriasis. 61
9727750 1998
14
[Monitoring of sE-selectin serum levels in three different dermatoses]. 61
9621489 1998
15
Photosensitizing compounds in the treatment of psoriasis. 61
2697531 1989
16
Eicosanoids in psoriasis--15-HETE on the stage. 61
3108043 1987
17
HL-A antigens in patients with persistent palmoplantar pustulosis and pustular psoriasis. 61
1181975 1975

Variations for Psoriasis 15

Expression for Psoriasis 15

Search GEO for disease gene expression data for Psoriasis 15.

Pathways for Psoriasis 15

Pathways related to Psoriasis 15 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.53 STAT5B MRC1 IL31 IL17F IL17A ELANE
2
Show member pathways
13.38 TYRO3 TSLP STAT5B IL31 IL17F IL17A
3 11.76 CD1E CD1C CD1B CD1A
4
Show member pathways
11.61 STAT5B IL17F IL17A
5
Show member pathways
11.5 STAT5B IL17F IL17A
6 11.37 CD83 CD1C CD1A
7 11.27 CD1E CD1C CD1B CD1A
8 10.92 CD1E CD1C CD1B CD1A

GO Terms for Psoriasis 15

Cellular components related to Psoriasis 15 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.77 TYRO3 MRC1 EPHA4 ELANE CD1B
2 integral component of plasma membrane GO:0005887 9.76 TYRO3 MRC1 EPHA4 EPHA1 CD83 CD1E
3 endosome GO:0005768 9.73 MRC1 EPHA4 CD1E CD1C CD1B CD1A
4 endosome membrane GO:0010008 9.62 MRC1 CD1C CD1B CD1A
5 external side of plasma membrane GO:0009897 9.43 IL17A CD83 CD1E CD1C CD1B CD1A
6 extracellular space GO:0005615 9.36 TSLP TAC1 IL31 IL17F IL17A ELANE

Biological processes related to Psoriasis 15 according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.85 LAMP3 IL31 CD1E CD1C CD1B CD1A
2 cytokine-mediated signaling pathway GO:0019221 9.8 STAT5B IL31 IL17F IL17A
3 adaptive immune response GO:0002250 9.8 LAMP3 CD1E CD1C CD1B CD1A
4 immune response GO:0006955 9.73 IL17A DEFB4A CD1E CD1C CD1B CD1A
5 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.69 TYRO3 EPHA4 EPHA1
6 viral entry into host cell GO:0046718 9.63 TYRO3 MRC1 LAMP3
7 positive regulation of kinase activity GO:0033674 9.61 TYRO3 EPHA4 EPHA1
8 natural killer cell differentiation GO:0001779 9.48 TYRO3 STAT5B
9 positive regulation of T cell mediated cytotoxicity GO:0001916 9.46 CD1E CD1C CD1B CD1A
10 interleukin-17-mediated signaling pathway GO:0097400 9.32 IL17F IL17A
11 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 9.26 CD1E CD1C CD1B CD1A
12 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 8.92 CD1E CD1C CD1B CD1A

Molecular functions related to Psoriasis 15 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.62 TSLP IL31 IL17F IL17A
2 protein tyrosine kinase activity GO:0004713 9.61 TYRO3 EPHA4 EPHA1
3 lipopeptide binding GO:0071723 9.46 CD1E CD1C CD1B CD1A
4 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.43 TYRO3 EPHA4 EPHA1
5 transmembrane-ephrin receptor activity GO:0005005 9.4 EPHA4 EPHA1
6 ephrin receptor activity GO:0005003 9.37 EPHA4 EPHA1
7 exogenous lipid antigen binding GO:0030884 9.26 CD1E CD1C CD1B CD1A
8 endogenous lipid antigen binding GO:0030883 8.92 CD1E CD1C CD1B CD1A

Sources for Psoriasis 15

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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