PSORS5
MCID: PSR026
MIFTS: 26

Psoriasis 5 (PSORS5)

Categories: Genetic diseases, Immune diseases, Rare diseases, Skin diseases

Aliases & Classifications for Psoriasis 5

MalaCards integrated aliases for Psoriasis 5:

Name: Psoriasis 5 57 12 15
Psoriasis Susceptibility 5 57 13
Psors5 57 12
Psoriasis 5, Susceptibility to 57

Classifications:



External Ids:

Disease Ontology 12 DOID:0111282
OMIM® 57 604316
OMIM Phenotypic Series 57 PS177900

Summaries for Psoriasis 5

Disease Ontology : 12 A psoriasis that has material basis in variation in a region on chromosome 3q21.

MalaCards based summary : Psoriasis 5, also known as psoriasis susceptibility 5, is related to skin disease and psoriasis 1. An important gene associated with Psoriasis 5 is PSORS5 (Psoriasis Susceptibility 5). The drugs Etanercept and Gastrointestinal Agents have been mentioned in the context of this disorder. Affiliated tissues include skin.

More information from OMIM: 604316 PS177900

Related Diseases for Psoriasis 5

Graphical network of the top 20 diseases related to Psoriasis 5:



Diseases related to Psoriasis 5

Symptoms & Phenotypes for Psoriasis 5

Clinical features from OMIM®:

604316 (Updated 20-May-2021)

Drugs & Therapeutics for Psoriasis 5

Drugs for Psoriasis 5 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etanercept Approved, Investigational 185243-69-0
2 Gastrointestinal Agents
3 Antirheumatic Agents
4 Immunosuppressive Agents
5 Anti-Inflammatory Agents
6 Analgesics, Non-Narcotic
7 Immunologic Factors
8 Anti-Inflammatory Agents, Non-Steroidal
9 Analgesics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy of Etanercept in Iraqi Patients With Moderate to Severe Psoriasis: 5 Years Data From Local Registry. Completed NCT04398732 Enbrel

Search NIH Clinical Center for Psoriasis 5

Genetic Tests for Psoriasis 5

Anatomical Context for Psoriasis 5

MalaCards organs/tissues related to Psoriasis 5:

40
Skin

Publications for Psoriasis 5

Articles related to Psoriasis 5:

(show all 35)
# Title Authors PMID Year
1
Association analysis of the skin barrier gene cystatin A at the PSORS5 locus in psoriatic patients: evidence for interaction between PSORS1 and PSORS5. 57 61
18364739 2008
2
Systematic linkage disequilibrium analysis of SLC12A8 at PSORS5 confirms a role in susceptibility to psoriasis vulgaris. 57 61
16297188 2005
3
Association analysis of cystatin A and zinc finger protein 148, two genes located at the psoriasis susceptibility locus PSORS5. 61 57
15175029 2004
4
Identification of a psoriasis susceptibility candidate gene by linkage disequilibrium mapping with a localized single nucleotide polymorphism map. 61 57
11863360 2002
5
Psoriasis susceptibility locus in chromosome region 3q21 identified in patients from southwest Sweden. 57
10573011 1999
6
Hydroxychloroquine effects on psoriasis: A systematic review and a cautionary note for COVID-19 treatment. 61
32442699 2020
7
Salvianolic acid B ameliorates psoriatic changes in imiquimod-induced psoriasis on BALB/c mice by inhibiting inflammatory and keratin markers via altering phosphatidylinositol-3-kinase/protein kinase B signaling pathway. 61
32395072 2020
8
Salvianolic acid B ameliorates psoriatic changes in imiquimod-induced psoriasis on BALB/c mice by inhibiting inflammatory and keratin markers via altering phosphatidylinositol-3-kinase/protein kinase B signaling pathway. 61
32392912 2020
9
Evaluation of Serum Adenosine Deaminase and Inflammatory Markers in Psoriatic Patients. 61
31148859 2019
10
Association Between Psoriasis and Sexual and Erectile Dysfunction in Epidemiologic Studies: A Systematic Review. 61
30304327 2019
11
Presence of stratum corneum serum in non-palmoplantar psoriasis. 61
29193195 2018
12
Prevalence of psoriatic arthritis and its correlates among patients with psoriasis in Greece: results from a large retrospective study. 61
27508394 2016
13
Oral tofacitinib efficacy, safety and tolerability in Japanese patients with moderate to severe plaque psoriasis and psoriatic arthritis: A randomized, double-blind, phase 3 study. 61
26875540 2016
14
Cardiovascular outcomes and systemic anti-inflammatory drugs in patients with severe psoriasis: 5-year follow-up of a Danish nationwide cohort. 61
25303139 2015
15
Induction of psoriasis with anti-TNF agents in patients with inflammatory bowel disease: a report of 21 cases. 61
22398059 2012
16
Comparison of bacterial microbiota in skin biopsies from normal and psoriatic skin. 61
22065152 2012
17
HLA-C, CSTA and DS12346 susceptibility alleles confer over 100-fold increased risk of developing psoriasis: evidence of gene interaction. 61
21412248 2011
18
Extraocular manifestations of birdshot chorioretinopathy in 118 French patients. 61
20219319 2010
19
HLA Antigens in Omani Psoriasis Vulgaris Patients. 61
22303505 2009
20
Moisturizing cream ameliorates dryness and desquamation in participants not receiving topical psoriasis treatment. 61
18856161 2008
21
Hair loss in children in South-East Nigeria: common and uncommon cases. 61
17919200 2007
22
Eugenol--the active principle from cloves inhibits 5-lipoxygenase activity and leukotriene-C4 in human PMNL cells. 61
16216483 2006
23
Analysis of 6 genetic loci for disease susceptibility in psoriatic arthritis. 61
15517637 2004
24
Topical application of natural honey, beeswax and olive oil mixture for atopic dermatitis or psoriasis: partially controlled, single-blinded study. 61
15022655 2003
25
Viral infection, atopy and mycosis fungoides: a European multicentre case-control study. 61
12751383 2003
26
Phase I trials of dexrazoxane and other potential applications for the agent. 61
9768821 1998
27
Topical psoralen-ultraviolet A therapy for palmoplantar dermatoses: experience with 35 consecutive patients. 61
9581579 1998
28
Corneocytes in scaly parakeratotic diseases. 61
8737877 1996
29
The commonest causes of symptomatic vulvar disease: a dermatologist's perspective. 61
8936065 1996
30
Correlation of lesional skin corneometry values with serum E-selectin levels and disease severity in patients affected by plaque-type psoriasis: recovery after effective therapy. 61
7560436 1995
31
Oral 5-fluorouracil in psoriasis: pharmacokinetic-pharmacodynamic relationships. 61
2798554 1989
32
[Dermatoses difficult to treat. Their treatment with an aromatic retinoid (etretinate)]. 61
6230492 1983
33
Histochemistry in psoriasis. 5'-Nucleotidase in psoriatic parakeratotic horny layer. 61
38755 1979
34
Psoriasis: odd varieties in the adult. 61
161135 1979
35
Intra-articular methotrexate. Clinical and laboratory study in rheumatoid and psoriatic arthritis. 61
356763 1978

Variations for Psoriasis 5

Expression for Psoriasis 5

Search GEO for disease gene expression data for Psoriasis 5.

Pathways for Psoriasis 5

GO Terms for Psoriasis 5

Cellular components related to Psoriasis 5 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornified envelope GO:0001533 8.62 CSTA CDSN

Biological processes related to Psoriasis 5 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornification GO:0070268 8.96 CSTA CDSN
2 keratinocyte differentiation GO:0030216 8.62 CSTA CDSN

Sources for Psoriasis 5

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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