MCID: PSR016
MIFTS: 37

Psoriatic Juvenile Idiopathic Arthritis

Categories: Rare diseases, Respiratory diseases, Bone diseases

Aliases & Classifications for Psoriatic Juvenile Idiopathic Arthritis

MalaCards integrated aliases for Psoriatic Juvenile Idiopathic Arthritis:

Name: Psoriatic Juvenile Idiopathic Arthritis 53 73
Juvenile Psoriatic Arthritis 53 59 73
Psoriasis-Related Juvenile Idiopathic Arthritis 53 59
Psoriasis-Related Jia 53 59
Juvenile Arthritis 73

Characteristics:

Orphanet epidemiological data:

59
psoriasis-related juvenile idiopathic arthritis
Age of onset: Childhood; Age of death: normal life expectancy;

Classifications:



External Ids:

Orphanet 59 ORPHA85436
UMLS via Orphanet 74 C0409672
ICD10 via Orphanet 34 L40.5+ M09.0*

Summaries for Psoriatic Juvenile Idiopathic Arthritis

NIH Rare Diseases : 53 Psoriatic juvenile idiopathic arthritis is a subtype of juvenile idiopathic arthritis that is characterized by both arthritis and psoriasis. Other signs and symptoms may include dactylitis (inflammation and swelling of an entire finger or toe); nail pitting or splitting; and eye problems. Although the underlying cause of psoriatic juvenile idiopathic arthritis is currently unknown (idiopathic), it is thought to occur due to a combination of genetic and environmental factors. It is very rare for more than one member of a family to have juvenile arthritis; however, research suggests that having a family member with juvenile arthritis or any autoimmune disease may increase the risk of having juvenile arthritis, in general. Treatment usually involves different types of medications to help manage symptoms and/or physical therapy.

MalaCards based summary : Psoriatic Juvenile Idiopathic Arthritis, also known as juvenile psoriatic arthritis, is related to psoriatic arthritis and arthritis. An important gene associated with Psoriatic Juvenile Idiopathic Arthritis is MEFV (MEFV, Pyrin Innate Immunity Regulator), and among its related pathways/superpathways are Innate Immune System and Toll-like Receptor Signaling Pathway. The drugs Certolizumab pegol and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include eye and bone, and related phenotypes are hematopoietic system and immune system

Related Diseases for Psoriatic Juvenile Idiopathic Arthritis

Diseases related to Psoriatic Juvenile Idiopathic Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 18)
# Related Disease Score Top Affiliating Genes
1 psoriatic arthritis 10.5
2 arthritis 10.2
3 uveitis 9.9
4 cervical adenitis 9.9 MEFV NLRP3
5 familial cold autoinflammatory syndrome 1 9.8 MEFV NLRP3
6 erysipeloid 9.8 MEFV NLRP3
7 periodic fever, familial, autosomal dominant 9.8 MEFV NLRP3
8 muckle-wells syndrome 9.8 MEFV NLRP3
9 cinca syndrome 9.7 MEFV NLRP3
10 wells syndrome 9.7 MEFV NLRP3
11 aphthous stomatitis 9.6 MEFV NLRP3
12 amyloidosis 9.2 MEFV NLRP3
13 lig4 syndrome 9.1 NLRP3 NOD2
14 pyoderma 9.0 MEFV NOD2 PSTPIP1
15 behcet syndrome 9.0 MEFV NOD2 PSTPIP1
16 blau syndrome 8.9 MEFV NLRP3 NOD2
17 pyoderma gangrenosum 8.3 MEFV NLRP3 NOD2 PSTPIP1
18 familial mediterranean fever 8.3 MEFV NLRP3 NOD2 PSTPIP1

Graphical network of the top 20 diseases related to Psoriatic Juvenile Idiopathic Arthritis:



Diseases related to Psoriatic Juvenile Idiopathic Arthritis

Symptoms & Phenotypes for Psoriatic Juvenile Idiopathic Arthritis

MGI Mouse Phenotypes related to Psoriatic Juvenile Idiopathic Arthritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.26 MEFV NLRP3 NOD2 PSTPIP1
2 immune system MP:0005387 8.92 MEFV NLRP3 NOD2 PSTPIP1

Drugs & Therapeutics for Psoriatic Juvenile Idiopathic Arthritis

Drugs for Psoriatic Juvenile Idiopathic Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Certolizumab pegol Approved Phase 3 428863-50-7
2
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
3
leucovorin Approved, Nutraceutical Phase 3 58-05-9 143 6006
4
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
5 Antibodies Phase 3
6 Immunoglobulins Phase 3
7 Antibodies, Monoclonal Phase 3
8 Pharmaceutical Solutions Phase 3
9 Immunosuppressive Agents Phase 3
10 Antirheumatic Agents Phase 3
11 Folic Acid Antagonists Phase 3
12 Dermatologic Agents Phase 3
13 Nucleic Acid Synthesis Inhibitors Phase 3
14 Vitamin B Complex Phase 3
15 Antimetabolites Phase 3
16 Antimetabolites, Antineoplastic Phase 3
17 Folate Nutraceutical Phase 3
18 Vitamin B9 Nutraceutical Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Secukinumab Safety and Efficacy in JPsA and ERA Recruiting NCT03031782 Phase 3 AIN457
2 Pediatric Arthritis Study of Certolizumab Pegol Active, not recruiting NCT01550003 Phase 3 Certolizumab Pegol (CZP)
3 A Study of the Safety and Efficacy of CNTO 148 (Golimumab) in Children With Juvenile Idiopathic Arthritis (JIA) and Multiple Joint Involvement Who Have Poor Response to Methotrexate (GO KIDS) Terminated NCT01230827 Phase 3 CNTO 148 (Golimumab);Placebo;Methotrexate

Search NIH Clinical Center for Psoriatic Juvenile Idiopathic Arthritis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Psoriatic Juvenile Idiopathic Arthritis

Anatomical Context for Psoriatic Juvenile Idiopathic Arthritis

MalaCards organs/tissues related to Psoriatic Juvenile Idiopathic Arthritis:

41
Eye, Bone

Publications for Psoriatic Juvenile Idiopathic Arthritis

Articles related to Psoriatic Juvenile Idiopathic Arthritis:

(show all 32)
# Title Authors Year
1
Early recognition and detection of juvenile psoriatic arthritis: a call for a standardized approach to screening. ( 28044348 )
2017
2
The conundrum of juvenile psoriatic arthritis. ( 26470604 )
2015
3
Enthesitis as a component of dactylitis in psoriatic juvenile idiopathic arthritis: histology of an established clinical entity. ( 25774101 )
2015
4
Psoriatic juvenile idiopathic arthritis associated with uveitis: a case report. ( 24191219 )
2013
5
Juvenile Psoriatic Arthritis (JPsA): juvenile arthritis with psoriasis? ( 23497068 )
2013
6
Subtype specific genetic associations for juvenile idiopathic arthritis: ERAP1 with the enthesitis related arthritis subtype and IL23R with juvenile psoriatic arthritis. ( 21281511 )
2011
7
Tumour necrosis factor (TNF)-blocking agents in juvenile psoriatic arthritis: are they effective? ( 21068101 )
2011
8
Psoriatic juvenile idiopathic arthritis: a tale of two subgroups. ( 21709556 )
2011
9
Juvenile psoriatic arthritis and comorbidities: report of a case associated with enthesitis and celiac disease. ( 20482570 )
2010
10
Extracapillary glomerulonephritis during etanercept treatment for juvenile psoriatic arthritis. ( 20346246 )
2010
11
Juvenile psoriatic arthritis: bathwater or baby? ( 19738207 )
2009
12
Juvenile psoriatic arthritis: longterm outcome and differentiation from other subtypes of juvenile idiopathic arthritis. ( 19208605 )
2009
13
Comparison of patients with juvenile psoriatic arthritis and nonpsoriatic juvenile idiopathic arthritis: how different are they? ( 19648305 )
2009
14
Comparison of Vancouver and International League of Associations for rheumatology classification criteria for juvenile psoriatic arthritis. ( 18163407 )
2008
15
Autoinflammatory genes and susceptibility to psoriatic juvenile idiopathic arthritis. ( 18576390 )
2008
16
MRI findings of juvenile psoriatic arthritis. ( 18594809 )
2008
17
Juvenile psoriatic arthritis carrying familial Mediterranean fever gene mutations in a 14-year-old Turkish girl. ( 17408446 )
2007
18
What is juvenile psoriatic arthritis? Comment on the article by Stoll et al. ( 17393443 )
2007
19
Patients with juvenile psoriatic arthritis comprise two distinct populations. ( 17075862 )
2006
20
Juvenile psoriatic arthritis and acquired sensorineural hearing loss in a teenager: is there an association? ( 16870107 )
2006
21
Subpopulations within juvenile psoriatic arthritis: a review of the literature. ( 17162381 )
2006
22
Patterns of joint involvement at onset differentiate oligoarticular juvenile psoriatic arthritis from pauciarticular juvenile rheumatoid arthritis. ( 12136915 )
2002
23
Juvenile psoriatic arthritis with nail psoriasis in the absence of cutaneous lesions. ( 10651963 )
2000
24
Juvenile psoriatic arthritis: a new clinical entity? ( 9035009 )
1997
25
Juvenile psoriatic arthritis: followup and evaluation of diagnostic criteria. ( 8838527 )
1996
26
Juvenile psoriatic arthritis, or juvenile arthritis with psoriasis? ( 7955628 )
1994
27
Prevalence and clinical features of juvenile psoriatic arthritis in 425 psoriatic patients. ( 8073804 )
1994
28
Juvenile psoriatic arthritis. ( 8076390 )
1994
29
HLA and juvenile psoriatic arthritis. ( 8369900 )
1993
30
Juvenile psoriatic arthritis. ( 1790632 )
1991
31
Juvenile psoriatic arthritis and HLA antigens. ( 2241285 )
1990
32
Juvenile psoriatic arthritis--an analysis of 60 cases. ( 7199570 )
1982

Variations for Psoriatic Juvenile Idiopathic Arthritis

Expression for Psoriatic Juvenile Idiopathic Arthritis

Search GEO for disease gene expression data for Psoriatic Juvenile Idiopathic Arthritis.

Pathways for Psoriatic Juvenile Idiopathic Arthritis

GO Terms for Psoriatic Juvenile Idiopathic Arthritis

Cellular components related to Psoriatic Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoskeleton GO:0005856 9.13 MEFV NOD2 PSTPIP1
2 lamellipodium GO:0030027 8.62 MEFV PSTPIP1

Biological processes related to Psoriatic Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.62 MEFV NLRP3 NOD2 PSTPIP1
2 regulation of gene expression GO:0010468 9.58 NLRP3 NOD2
3 defense response GO:0006952 9.58 NLRP3 NOD2
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.57 NLRP3 NOD2
5 negative regulation of NF-kappaB transcription factor activity GO:0032088 9.56 NLRP3 NOD2
6 innate immune response GO:0045087 9.56 MEFV NLRP3 NOD2 PSTPIP1
7 regulation of inflammatory response GO:0050727 9.55 NLRP3 NOD2
8 protein complex oligomerization GO:0051259 9.54 NLRP3 NOD2
9 negative regulation of inflammatory response GO:0050728 9.54 MEFV NLRP3 NOD2
10 regulation of cytokine production GO:0001817 9.52 NLRP3 NOD2
11 signaling GO:0023052 9.51 NLRP3 NOD2
12 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.49 NLRP3 NOD2
13 negative regulation of immune response GO:0050777 9.48 NLRP3 NOD2
14 positive regulation of interleukin-1 beta secretion GO:0050718 9.46 NLRP3 NOD2
15 positive regulation of type 2 immune response GO:0002830 9.43 NLRP3 NOD2
16 cellular response to peptidoglycan GO:0071224 9.4 NLRP3 NOD2
17 detection of biotic stimulus GO:0009595 9.16 NLRP3 NOD2
18 cytokine secretion involved in immune response GO:0002374 8.96 NLRP3 NOD2
19 inflammatory response GO:0006954 8.92 MEFV NLRP3 NOD2 PSTPIP1

Molecular functions related to Psoriatic Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.13 MEFV NLRP3 PSTPIP1
2 peptidoglycan binding GO:0042834 8.62 NLRP3 NOD2

Sources for Psoriatic Juvenile Idiopathic Arthritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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