MCID: PDN001
MIFTS: 31

Pudendal Neuralgia

Categories: Nephrological diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Pudendal Neuralgia

MalaCards integrated aliases for Pudendal Neuralgia:

Name: Pudendal Neuralgia 53 59 72
Pudendal Nerve Entrapment Syndrome 59 72
Pudendal Neuralgia by Pudendal Nerve Entrapment 59
Alcock Syndrome 59
Pudendal Algia 59
Pudendalgia 59

Characteristics:

Orphanet epidemiological data:

59
pudendal neuralgia
Inheritance: Not applicable; Prevalence: 1-5/10000 (France); Age of onset: Adult; Age of death: normal life expectancy;

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

MESH via Orphanet 45 D060545
UMLS via Orphanet 73 C1997249 C3178970
Orphanet 59 ORPHA60039
UMLS 72 C1997249 C3178970

Summaries for Pudendal Neuralgia

NIH Rare Diseases : 53 Pudendal neuralgia occurs when the pudendal nerve is injured, irritated, or compressed. Symptoms include burning pain (often unilateral), tingling, or numbness in any of the following areas: buttocks, genitals, or perineum (area between the buttocks and genitals). Symptoms are typically present when a person is sitting but often go away when the person is standing or lying down. The pain tends to increase as the day progresses. Additional symptoms include pain during sex and needing to urinate frequently and/or urgently. Damage to the pudendal nerve can result from surgical procedures, childbirth, trauma, spasms of the pelvic floor muscles, or tumors. Pudendal neuralgia may also result from certain infections (such as herpes simplex infections) or certain activities (such as cycling and squatting exercises). There are no imaging studies that diagnose pudendal neuralgia; however, MRI and CT may help to exclude other causes of the pain. Physical therapy is often the first line of treatment.

MalaCards based summary : Pudendal Neuralgia, also known as pudendal nerve entrapment syndrome, is related to chronic pain and vascular disease, and has symptoms including sciatica, pelvic pain and neuralgia. The drugs Lidocaine and Prednisolone phosphate have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, prostate and testes, and related phenotypes are constipation and back pain

Wikipedia : 75 Pudendal nerve entrapment (PNE), also known as Alcock canal syndrome, is an uncommon source of chronic... more...

Related Diseases for Pudendal Neuralgia

Diseases related to Pudendal Neuralgia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)
# Related Disease Score Top Affiliating Genes
1 chronic pain 10.4
2 vascular disease 10.2
3 polykaryocytosis inducer 10.1
4 hydrops, lactic acidosis, and sideroblastic anemia 10.1
5 neuropathy 10.1
6 chordoma 10.0
7 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.0
8 sexual disorder 10.0
9 prostatitis 10.0
10 neuroma 10.0
11 constipation 10.0
12 neurofibroma 10.0
13 tarlov cysts 10.0
14 paresthesia 10.0

Graphical network of the top 20 diseases related to Pudendal Neuralgia:



Diseases related to Pudendal Neuralgia

Symptoms & Phenotypes for Pudendal Neuralgia

Human phenotypes related to Pudendal Neuralgia:

59 32 (show all 18)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 constipation 59 32 hallmark (90%) Very frequent (99-80%) HP:0002019
2 back pain 59 32 hallmark (90%) Very frequent (99-80%) HP:0003418
3 paresthesia 59 32 hallmark (90%) Very frequent (99-80%) HP:0003401
4 episodic abdominal pain 59 32 hallmark (90%) Very frequent (99-80%) HP:0002574
5 pollakisuria 59 32 hallmark (90%) Very frequent (99-80%) HP:0100515
6 dyspareunia 59 32 hallmark (90%) Very frequent (99-80%) HP:0030016
7 impotence 59 32 hallmark (90%) Very frequent (99-80%) HP:0000802
8 dysuria 59 32 hallmark (90%) Very frequent (99-80%) HP:0100518
9 abdominal colic 59 32 hallmark (90%) Very frequent (99-80%) HP:0011848
10 scrotal pain 59 32 hallmark (90%) Very frequent (99-80%) HP:0030155
11 vulvodynia 59 32 hallmark (90%) Very frequent (99-80%) HP:0030943
12 pruritus 59 Excluded (0%)
13 insomnia 59 Excluded (0%)
14 sensory impairment 59 Excluded (0%)
15 epigastric pain 59 Excluded (0%)
16 genital neoplasm 59 Excluded (0%)
17 anal canal adenocarcinoma 59 Excluded (0%)
18 neoplasm of the genitourinary tract 59 Excluded (0%)

UMLS symptoms related to Pudendal Neuralgia:


sciatica, pelvic pain, neuralgia

Drugs & Therapeutics for Pudendal Neuralgia

Drugs for Pudendal Neuralgia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
2
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
3
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
4
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
5
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
6
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
7 Sodium Channel Blockers Phase 4
8 Prednisolone acetate Phase 4
9 Diuretics, Potassium Sparing Phase 4
10 Peripheral Nervous System Agents Phase 4
11 Methylprednisolone Acetate Phase 4
12 Central Nervous System Depressants Phase 4
13 Anti-Arrhythmia Agents Phase 4
14
Acetylcholine Approved, Investigational Phase 2 51-84-3 187
15 Analgesics Phase 2
16 Neurotransmitter Agents Phase 2
17 abobotulinumtoxinA Phase 2
18 Neuromuscular Agents Phase 2
19 Cholinergic Agents Phase 2
20 Acetylcholine Release Inhibitors Phase 2
21 Botulinum Toxins Phase 2
22 Botulinum Toxins, Type A Phase 2
23 Antidepressive Agents
24 PENTA
25 Anticonvulsants
26 Anesthetics, Local
27 Anesthetics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Therapeutic Effects Analysis of Pudendal Nerve Infiltrations After 3 Months, in Patients Suffering of Pudendal Neuralgia Completed NCT00851513 Phase 4 Lidocaine;Depmedrol
2 Prospective Multicenter Pilot Study Evaluating the Analgesic Effect of an Injection of Botulinum Toxin Type A in the Ganglion Impar in Patients With Chronic Proctalgia According to the Criteria of Rome III Completed NCT01331356 Phase 2 Botox
3 Psychosocial Factors and Central Sensitization in Chronic Pelvic Pain Unknown status NCT02856334
4 Comparative Study Between Delorme Operation With or Without Postanal Repair and Levatorplasty in Treatment of Complete Rectal Prolapse. Completed NCT01656369
5 Comparison of Ultrasound-guided Transgluteal and Finger-guided Transvaginal Pudendal Nerve Block Techniques: Which One is More Effective? Completed NCT03973983
6 Conus Medullaris Stimulation With 5 Columns Lead Versus Medical Treatment in Refractory Pudendal Neuralgia: a Randomized, Open, Controlled, Multicenter Trial. Recruiting NCT02564172
7 Adipose Derived Stem Cell Transplantation Via Lipofilling for Vestibulodynia: a Controlled Intervention Study Recruiting NCT03431779
8 Indirect Non-invasive Evaluation of Pudendal Neuropathy by Dynamic Transperineal Ultrasound in Patients With Pelvic Floor Dysfunction Active, not recruiting NCT03933683
9 Robotic Decompression of the Pudendal Nerve in Pudendal Neuralgia: A Randomized Controlled Trial Not yet recruiting NCT03876977
10 Does Neurostimulation Improve Efficacy for Ultrasound-Guided Transperineal Pudendal Nerve Block In Children: A Randomized Clinical Trial Not yet recruiting NCT03931850

Search NIH Clinical Center for Pudendal Neuralgia

Genetic Tests for Pudendal Neuralgia

Anatomical Context for Pudendal Neuralgia

MalaCards organs/tissues related to Pudendal Neuralgia:

41
Spinal Cord, Prostate, Testes, Cervix, Dorsal Root Ganglion

Publications for Pudendal Neuralgia

Articles related to Pudendal Neuralgia:

(show top 50) (show all 124)
# Title Authors PMID Year
1
Management of pudendal neuralgia. 38 6
24716710 2014
2
Pudendal neuralgia. 38 6
25155124 2014
3
Evaluating the discordant relationship between Tarlov cysts and symptoms of pudendal neuralgia. 38
31319080 2019
4
Role of 3 Tesla MR Neurography and CT-guided Injections for Pudendal Neuralgia: Analysis of Pain Response. 38
31337177 2019
5
Osteopathic manipulative treatment in pudendal neuralgia: A case report. 38
31103103 2019
6
The Use of Pulsed Radiofrequency for the Treatment of Pudendal Neuralgia: A Case Series. 38
30910339 2019
7
Vascular Entrapment of Both the Sciatic and Pudendal Nerves Causing Persistent Sciatica and Pudendal Neuralgia. 38
29702268 2019
8
Differentiating overlapping symptoms of vulvodynia and pudendal neuralgia. 38
30671239 2019
9
The drug-resistant pudendal neuralgia management: A systematic review. 38
30375046 2019
10
Dorsal Root Ganglion Stimulation for Chronic Pelvic Pain: A Case Series and Technical Report on a Novel Lead Configuration. 38
30067887 2019
11
Chronic prostatitis: current treatment options. 38
31240202 2019
12
Comment to «Robot-assisted pudendal neurolysis in the treatment of pudendal nerve entrapment syndrome». 38
29910138 2018
13
A Rare Ultrasonographic Finding in Pudendal Neuralgia: Posteriorly Prolapsed Cervix. 38
29618089 2018
14
Robot-assisted pudendal neurolysis in the treatment of pudendal nerve entrapment syndrome. 38
29526251 2018
15
Efficacy of Pulsed Radiofrequency Stimulation in Patients with Peripheral Neuropathic Pain: A Narrative Review. 38
29871378 2018
16
Ultrasound Imaging and Guided Injection for the Lateral and Posterior Hip. 38
29324458 2018
17
Dual Site Pudendal Nerve Infiltration: More than Just a Diagnostic Test? 38
29357337 2018
18
Clinical effect and safety of pulsed radiofrequency treatment for pudendal neuralgia: a prospective, randomized controlled clinical trial. 38
30410389 2018
19
Correlation between Anatomical Segments of the Pudendal Nerve and Clinical Findings of the Patient with Pudendal Neuralgia. 38
30007962 2018
20
Fully endoscopic interlaminar and transforaminal lumbar discectomy: Analysis of 47 complications encountered in a series of 835 patients. 38
28532963 2017
21
Repeated Ganglion Impar Block in a Cohort of 83 Patients with Chronic Pelvic and Perineal Pain. 38
28934788 2017
22
Neurogenic Pelvic Pain. 38
28676364 2017
23
Entrapment of the posterior femoral cutaneous nerve and its inferior cluneal branches: anatomical basis of surgery for inferior cluneal neuralgia. 38
28236130 2017
24
Re: Adding corticosteroids to the pudendal nerve block for pudendal neuralgia: a randomised, double-blind, controlled trial. 38
28544719 2017
25
Authors' reply re: Adding corticosteroids to the pudendal nerve block for pudendal neuralgia: a randomised, double-blind, controlled trial. 38
28544720 2017
26
Pudendal nerve and branch neuropathy: magnetic resonance neurography evaluation. 38
27664277 2017
27
[Pudendal neuralgia diagnosed by electrophysiological examination]. 38
28553916 2017
28
Selection criteria for surgical treatment of pudendal neuralgia. 38
26999519 2017
29
Pulsed Radiofrequency Ablation of Pudendal Nerve for Treatment of a Case of Refractory Pelvic Pain. 38
28339446 2017
30
[Magnetic resonance neurography for the identification of pudendal neuralgia]. 38
28643681 2017
31
Adding corticosteroids to the pudendal nerve block for pudendal neuralgia: a randomised, double-blind, controlled trial. 38
27465823 2017
32
Anatomical Variants of the Pudendal Nerve Observed during a Transgluteal Surgical Approach in a Population of Patients with Pudendal Neuralgia. 38
28072805 2017
33
Pudendal neuralgia after pelvic surgery using mesh: Case reports and laparoscopic pudendal nerve decompression. 38
27250921 2016
34
Nontraumatic Testicular Pain due to Sacroiliac-Joint Dysfunction: A Case Report. 38
27626835 2016
35
Pudendal Nerve Entrapment Syndrome due to a Ganglion Cyst: A Case Report. 38
27606282 2016
36
Combined site-specific sacral neuromodulation and pudendal nerve release surgery in a patient with interstitial cystitis and persistent arousal. 38
27284095 2016
37
Measuring the Quality of Pudendal Nerve Perineural Injections. 38
27228517 2016
38
Pudendal Neuralgia as the Initial Manifestation of Infiltrative Sacrococcygeal Chordoma. 38
27721781 2016
39
Management of pudendal neuralgia using ultrasound-guided pulsed radiofrequency: a report of two cases and discussion of pudendal nerve block techniques. 38
26699147 2016
40
New perineal injection technique for pudendal nerve infiltration in diagnostic and therapeutic procedures. 38
26374644 2016
41
Pudendal Neuralgia Due to Pudendal Nerve Entrapment: Warning Signs Observed in Two Cases and Review of the Literature. 38
27008300 2016
42
Ultrasound-guided pulsed radiofrequency treatment of the pudendal nerve in chronic pelvic pain. 38
26811947 2016
43
Pelvic Neuralgias by Neuro-Vascular Entrapment: Anatomical Findings in a Series of 97 Consecutive Patients Treated by Laparoscopic Nerve Decompression. 38
26606029 2015
44
Anatomic variations of pudendal nerve within pelvis and pudendal canal: clinical applications. 38
26070708 2015
45
Chronic pelvic pain: An imaging approach. 38
26441020 2015
46
Pilot Study Exploring Chronic Pudendal Neuromodulation as a Treatment Option for Pain Associated with Pudendal Neuralgia. 38
26663728 2015
47
Pudendal Neuralgia: A New Option for Treatment? Preliminary Results on Feasibility and Efficacy. 38
25677417 2015
48
Percutaneous CT-guided cryoablation for the treatment of refractory pudendal neuralgia. 38
25511935 2015
49
The first case of robotic pudendal nerve decompression in pudendal nerve entrapment syndrome. 38
25790267 2015
50
[Neuromodulation - new techniques]. 38
25784446 2015

Variations for Pudendal Neuralgia

Expression for Pudendal Neuralgia

Search GEO for disease gene expression data for Pudendal Neuralgia.

Pathways for Pudendal Neuralgia

GO Terms for Pudendal Neuralgia

Sources for Pudendal Neuralgia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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