MCID: PDN001
MIFTS: 31

Pudendal Neuralgia

Categories: Nephrological diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Pudendal Neuralgia

MalaCards integrated aliases for Pudendal Neuralgia:

Name: Pudendal Neuralgia 52 58 71
Pudendal Nerve Entrapment Syndrome 58 71
Pudendal Neuralgia by Pudendal Nerve Entrapment 58
Alcock Syndrome 58
Pudendal Algia 58
Pudendalgia 58

Characteristics:

Orphanet epidemiological data:

58
pudendal neuralgia
Inheritance: Not applicable; Prevalence: 1-5/10000 (France); Age of onset: Adult; Age of death: normal life expectancy;

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

MESH via Orphanet 44 D060545
UMLS via Orphanet 72 C1997249 C3178970
Orphanet 58 ORPHA60039
UMLS 71 C1997249 C3178970

Summaries for Pudendal Neuralgia

NIH Rare Diseases : 52 Pudendal neuralgia occurs when the pudendal nerve is injured, irritated, or compressed. Symptoms include burning pain (often unilateral), tingling, or numbness in any of the following areas: buttocks, genitals, or perineum (area between the buttocks and genitals). Symptoms are typically present when a person is sitting but often go away when the person is standing or lying down. The pain tends to increase as the day progresses. Additional symptoms include pain during sex and needing to urinate frequently and/or urgently. Damage to the pudendal nerve can result from surgical procedures, childbirth, trauma, spasms of the pelvic floor muscles, or tumors . Pudendal neuralgia may also result from certain infections (such as herpes simplex infections) or certain activities (such as cycling and squatting exercises). There are no imaging studies that diagnose pudendal neuralgia; however, MRI and CT may help to exclude other causes of the pain. Physical therapy is often the first line of treatment.

MalaCards based summary : Pudendal Neuralgia, also known as pudendal nerve entrapment syndrome, is related to chronic pain and vascular disease, and has symptoms including sciatica, pelvic pain and neuralgia. The drugs Methylprednisolone and Methylprednisolone hemisuccinate have been mentioned in the context of this disorder. Affiliated tissues include prostate, spinal cord and testes, and related phenotypes are constipation and back pain

Wikipedia : 74 Pudendal nerve entrapment (PNE), also known as Alcock canal syndrome, is an uncommon source of chronic... more...

Related Diseases for Pudendal Neuralgia

Diseases related to Pudendal Neuralgia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
# Related Disease Score Top Affiliating Genes
1 chronic pain 10.4
2 vascular disease 10.2
3 polykaryocytosis inducer 10.1
4 hydrops, lactic acidosis, and sideroblastic anemia 10.1
5 neuropathy 10.1
6 chordoma 10.1
7 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.1
8 sexual disorder 10.1
9 prostatitis 10.1
10 neuroma 10.1
11 constipation 10.1
12 fibromyalgia 10.1
13 neurofibroma 10.1
14 tarlov cysts 10.1
15 paresthesia 10.1

Graphical network of the top 20 diseases related to Pudendal Neuralgia:



Diseases related to Pudendal Neuralgia

Symptoms & Phenotypes for Pudendal Neuralgia

Human phenotypes related to Pudendal Neuralgia:

58 31 (show all 18)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 constipation 58 31 hallmark (90%) Very frequent (99-80%) HP:0002019
2 back pain 58 31 hallmark (90%) Very frequent (99-80%) HP:0003418
3 paresthesia 58 31 hallmark (90%) Very frequent (99-80%) HP:0003401
4 episodic abdominal pain 58 31 hallmark (90%) Very frequent (99-80%) HP:0002574
5 pollakisuria 58 31 hallmark (90%) Very frequent (99-80%) HP:0100515
6 dyspareunia 58 31 hallmark (90%) Very frequent (99-80%) HP:0030016
7 impotence 58 31 hallmark (90%) Very frequent (99-80%) HP:0000802
8 dysuria 58 31 hallmark (90%) Very frequent (99-80%) HP:0100518
9 abdominal colic 58 31 hallmark (90%) Very frequent (99-80%) HP:0011848
10 scrotal pain 58 31 hallmark (90%) Very frequent (99-80%) HP:0030155
11 vulvodynia 58 31 hallmark (90%) Very frequent (99-80%) HP:0030943
12 pruritus 58 Excluded (0%)
13 insomnia 58 Excluded (0%)
14 sensory impairment 58 Excluded (0%)
15 epigastric pain 58 Excluded (0%)
16 genital neoplasm 58 Excluded (0%)
17 anal canal adenocarcinoma 58 Excluded (0%)
18 neoplasm of the genitourinary tract 58 Excluded (0%)

UMLS symptoms related to Pudendal Neuralgia:


sciatica, pelvic pain, neuralgia

Drugs & Therapeutics for Pudendal Neuralgia

Drugs for Pudendal Neuralgia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
2
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
3
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
4
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
5 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
6
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
7
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
8 Anti-Arrhythmia Agents Phase 4
9 Methylprednisolone Acetate Phase 4
10 Sodium Channel Blockers Phase 4
11 Central Nervous System Depressants Phase 4
12 Diuretics, Potassium Sparing Phase 4
13
Acetylcholine Approved, Investigational Phase 2 51-84-3 187
14 Analgesics Phase 2
15 abobotulinumtoxinA Phase 2
16 Neurotransmitter Agents Phase 2
17 Acetylcholine Release Inhibitors Phase 2
18 Neuromuscular Agents Phase 2
19 Botulinum Toxins Phase 2
20 Cholinergic Agents Phase 2
21 Botulinum Toxins, Type A Phase 2
22
Triamcinolone Approved, Vet_approved 124-94-7 31307
23
Bupivacaine Approved, Investigational 38396-39-3, 2180-92-9 2474
24 Anticonvulsants
25 Antidepressive Agents
26 PENTA
27 Triamcinolone diacetate
28 Triamcinolone hexacetonide
29 triamcinolone acetonide
30 Anesthetics, Local
31 Anesthetics

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Therapeutic Effects Analysis of Pudendal Nerve Infiltrations After 3 Months, in Patients Suffering of Pudendal Neuralgia Completed NCT00851513 Phase 4 Lidocaine;Depmedrol
2 Prospective Multicenter Pilot Study Evaluating the Analgesic Effect of an Injection of Botulinum Toxin Type A in the Ganglion Impar in Patients With Chronic Proctalgia According to the Criteria of Rome III Completed NCT01331356 Phase 2 Botox
3 Psychosocial Factors and Central Sensitization in Chronic Pelvic Pain Unknown status NCT02856334
4 Comparative Study Between Delorme Operation With or Without Postanal Repair and Levatorplasty in Treatment of Complete Rectal Prolapse. Completed NCT01656369
5 Comparison of Ultrasound-guided Transgluteal and Finger-guided Transvaginal Pudendal Nerve Block Techniques: Which One is More Effective? Completed NCT03973983
6 Conus Medullaris Stimulation With 5 Columns Lead Versus Medical Treatment in Refractory Pudendal Neuralgia: a Randomized, Open, Controlled, Multicenter Trial. Recruiting NCT02564172
7 The Effect of Pudendal Nerve Block Analgesia on Postoperative Pain Control in Patients Undergoing Vaginal Surgery: A Randomized Double-blind Placebo-controlled Trial Recruiting NCT04198714
8 Adipose Derived Stem Cell Transplantation Via Lipofilling for Vestibulodynia: a Controlled Intervention Study Recruiting NCT03431779
9 Indirect Non-invasive Evaluation of Pudendal Neuropathy by Dynamic Transperineal Ultrasound in Patients With Pelvic Floor Dysfunction Active, not recruiting NCT03933683
10 Robotic Decompression of the Pudendal Nerve in Pudendal Neuralgia: A Randomized Controlled Trial Not yet recruiting NCT03876977
11 Does Neurostimulation Improve Efficacy for Ultrasound-Guided Transperineal Pudendal Nerve Block In Children: A Randomized Clinical Trial Not yet recruiting NCT03931850

Search NIH Clinical Center for Pudendal Neuralgia

Genetic Tests for Pudendal Neuralgia

Anatomical Context for Pudendal Neuralgia

MalaCards organs/tissues related to Pudendal Neuralgia:

40
Prostate, Spinal Cord, Testes, Cervix, Dorsal Root Ganglion

Publications for Pudendal Neuralgia

Articles related to Pudendal Neuralgia:

(show top 50) (show all 129)
# Title Authors PMID Year
1
Management of pudendal neuralgia. 61 52
24716710 2014
2
Pudendal neuralgia. 61 52
25155124 2014
3
Estimate of the proportion of uncertain diagnoses of pudendal neuralgia in women with chronic pelvic-perineal pain: A systematic review with a descriptive data synthesis. 61
32022321 2020
4
Evaluating the discordant relationship between Tarlov cysts and symptoms of pudendal neuralgia. 61
31319080 2020
5
Comparison of Ultrasound-Guided Transgluteal and Finger-Guided Transvaginal Pudendal Nerve Block Techniques: Which One is More Effective? 61
31905278 2019
6
The Use of Pulsed Radiofrequency for the Treatment of Pudendal Neuralgia: A Case Series. 61
30910339 2019
7
[Intraoperative neurophysiological monitoring in radical prostatectomy and pudendal nerve surgical releasing.] 61
31579045 2019
8
Role of 3 Tesla MR Neurography and CT-guided Injections for Pudendal Neuralgia: Analysis of Pain Response. 61
31337177 2019
9
Osteopathic manipulative treatment in pudendal neuralgia: A case report. 61
31103103 2019
10
A rare and late presentation of pudendal neuralgia in a patient with fibromyalgia after pilates exercises. 61
31453547 2019
11
Vascular Entrapment of Both the Sciatic and Pudendal Nerves Causing Persistent Sciatica and Pudendal Neuralgia. 61
29702268 2019
12
Differentiating overlapping symptoms of vulvodynia and pudendal neuralgia. 61
30671239 2019
13
The drug-resistant pudendal neuralgia management: A systematic review. 61
30375046 2019
14
[Mechanisms of formation and diagnosis of tunnel pudendal neuropathy]. 61
31851179 2019
15
Dorsal Root Ganglion Stimulation for Chronic Pelvic Pain: A Case Series and Technical Report on a Novel Lead Configuration. 61
30067887 2019
16
Chronic prostatitis: current treatment options. 61
31240202 2019
17
Comment to «Robot-assisted pudendal neurolysis in the treatment of pudendal nerve entrapment syndrome». 61
29910138 2018
18
A Rare Ultrasonographic Finding in Pudendal Neuralgia: Posteriorly Prolapsed Cervix. 61
29618089 2018
19
Robot-assisted pudendal neurolysis in the treatment of pudendal nerve entrapment syndrome. 61
29526251 2018
20
Efficacy of Pulsed Radiofrequency Stimulation in Patients with Peripheral Neuropathic Pain: A Narrative Review. 61
29871378 2018
21
Ultrasound Imaging and Guided Injection for the Lateral and Posterior Hip. 61
29324458 2018
22
Dual Site Pudendal Nerve Infiltration: More than Just a Diagnostic Test? 61
29357337 2018
23
Clinical effect and safety of pulsed radiofrequency treatment for pudendal neuralgia: a prospective, randomized controlled clinical trial. 61
30410389 2018
24
Correlation between Anatomical Segments of the Pudendal Nerve and Clinical Findings of the Patient with Pudendal Neuralgia. 61
30007962 2018
25
Fully endoscopic interlaminar and transforaminal lumbar discectomy: Analysis of 47 complications encountered in a series of 835 patients. 61
28532963 2017
26
Repeated Ganglion Impar Block in a Cohort of 83 Patients with Chronic Pelvic and Perineal Pain. 61
28934788 2017
27
Neurogenic Pelvic Pain. 61
28676364 2017
28
Entrapment of the posterior femoral cutaneous nerve and its inferior cluneal branches: anatomical basis of surgery for inferior cluneal neuralgia. 61
28236130 2017
29
Re: Adding corticosteroids to the pudendal nerve block for pudendal neuralgia: a randomised, double-blind, controlled trial. 61
28544719 2017
30
Authors' reply re: Adding corticosteroids to the pudendal nerve block for pudendal neuralgia: a randomised, double-blind, controlled trial. 61
28544720 2017
31
Pudendal nerve and branch neuropathy: magnetic resonance neurography evaluation. 61
27664277 2017
32
[Pudendal neuralgia diagnosed by electrophysiological examination]. 61
28553916 2017
33
Selection criteria for surgical treatment of pudendal neuralgia. 61
26999519 2017
34
Pulsed Radiofrequency Ablation of Pudendal Nerve for Treatment of a Case of Refractory Pelvic Pain. 61
28339446 2017
35
[Magnetic resonance neurography for the identification of pudendal neuralgia]. 61
28643681 2017
36
Adding corticosteroids to the pudendal nerve block for pudendal neuralgia: a randomised, double-blind, controlled trial. 61
27465823 2017
37
Anatomical Variants of the Pudendal Nerve Observed during a Transgluteal Surgical Approach in a Population of Patients with Pudendal Neuralgia. 61
28072805 2017
38
Pudendal neuralgia after pelvic surgery using mesh: Case reports and laparoscopic pudendal nerve decompression. 61
27250921 2016
39
Pudendal Nerve Entrapment Syndrome due to a Ganglion Cyst: A Case Report. 61
27606282 2016
40
Nontraumatic Testicular Pain due to Sacroiliac-Joint Dysfunction: A Case Report. 61
27626835 2016
41
Combined site-specific sacral neuromodulation and pudendal nerve release surgery in a patient with interstitial cystitis and persistent arousal. 61
27284095 2016
42
Measuring the Quality of Pudendal Nerve Perineural Injections. 61
27228517 2016
43
Pudendal Neuralgia as the Initial Manifestation of Infiltrative Sacrococcygeal Chordoma. 61
27721781 2016
44
Management of pudendal neuralgia using ultrasound-guided pulsed radiofrequency: a report of two cases and discussion of pudendal nerve block techniques. 61
26699147 2016
45
New perineal injection technique for pudendal nerve infiltration in diagnostic and therapeutic procedures. 61
26374644 2016
46
Pudendal Neuralgia Due to Pudendal Nerve Entrapment: Warning Signs Observed in Two Cases and Review of the Literature. 61
27008300 2016
47
Ultrasound-guided pulsed radiofrequency treatment of the pudendal nerve in chronic pelvic pain. 61
26811947 2016
48
Pelvic Neuralgias by Neuro-Vascular Entrapment: Anatomical Findings in a Series of 97 Consecutive Patients Treated by Laparoscopic Nerve Decompression. 61
26606029 2015
49
Anatomic variations of pudendal nerve within pelvis and pudendal canal: clinical applications. 61
26070708 2015
50
Chronic pelvic pain: An imaging approach. 61
26441020 2015

Variations for Pudendal Neuralgia

Expression for Pudendal Neuralgia

Search GEO for disease gene expression data for Pudendal Neuralgia.

Pathways for Pudendal Neuralgia

GO Terms for Pudendal Neuralgia

Sources for Pudendal Neuralgia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....