MCID: PLM180
MIFTS: 34

Pulmonary Artery Disease

Categories: Cardiovascular diseases, Respiratory diseases

Aliases & Classifications for Pulmonary Artery Disease

MalaCards integrated aliases for Pulmonary Artery Disease:

Name: Pulmonary Artery Disease 12 15
Abnormality of the Pulmonary Artery 29

Classifications:



External Ids:

Disease Ontology 12 DOID:60001

Summaries for Pulmonary Artery Disease

Disease Ontology : 12 An artery disease that is located in the lungs.

MalaCards based summary : Pulmonary Artery Disease, also known as abnormality of the pulmonary artery, is related to tetralogy of fallot and arteries, anomalies of. An important gene associated with Pulmonary Artery Disease is SERPINC1 (Serpin Family C Member 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. Affiliated tissues include heart, endothelial and smooth muscle, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 73 A pulmonary artery is an artery in the pulmonary circulation that carries deoxygenated blood from the... more...

Related Diseases for Pulmonary Artery Disease

Diseases related to Pulmonary Artery Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 473)
# Related Disease Score Top Affiliating Genes
1 tetralogy of fallot 30.0 TNNT2 TNNI3 NPPB CRP ACE
2 arteries, anomalies of 30.0 TNNI3 SERPINE1 SERPINA3 PLG MIR126 F3
3 orbital osteomyelitis 10.5 F2 CRP
4 non-a-e hepatitis 10.5 F2 ALB
5 antipyrine metabolism 10.5 F2 ALB
6 small intestine diverticulitis 10.5 F2 CRP
7 spinal cord infarction 10.5 SERPINC1 F2
8 basal ganglia cerebrovascular disease 10.5 PLG PLAT
9 lateral sinus thrombosis 10.5 SERPINC1 F2
10 chronic duodenal ileus 10.5 CRP ALB
11 blue toe syndrome 10.5 SERPINC1 CRP
12 cerebral arteritis 10.5 SERPINC1 CRP
13 ligneous conjunctivitis 10.5 PLG PLAT
14 hematocele of tunica vaginalis testis 10.5 F2 CRP
15 vulvar angiokeratoma 10.5 SERPINC1 F3
16 hemopneumothorax 10.5 F3 F2
17 anterior spinal artery syndrome 10.5 PLG F2
18 arteritic anterior ischemic optic neuropathy 10.5 F2 ACE
19 giant hemangioma 10.5 SERPINC1 F3 F2
20 waterhouse-friderichsen syndrome 10.5 SERPINC1 F3 F2
21 achenbach syndrome 10.5 F3 F2 CRP
22 acquired hemophilia 10.5 F3 F10
23 thoracic outlet syndrome 10.5 SERPINC1 PLG F2
24 intracranial hypotension 10.5 SERPINC1 F3 F2
25 femoral neuropathy 10.5 PLAT F3 F2
26 renal pelvis squamous cell carcinoma 10.5 F3 F2 CRP
27 emphysematous cholecystitis 10.5 F3 F2 CRP
28 abducens nerve disease 10.5 SERPINC1 F2 CRP
29 basilar artery occlusion 10.5 PLG PLAT F2
30 pituitary adenoma 5, multiple types 10.5 SERPINC1 F3 F2
31 basilar artery insufficiency 10.5 PLG PLAT
32 lemierre's syndrome 10.5 F3 F2 CRP
33 mastoiditis 10.5 SERPINC1 F2 CRP
34 prothrombin deficiency, congenital 10.5 SERPINC1 F2 F10
35 subclavian steal syndrome 10.5 F3 CRP
36 thrombotic microangiopathy 10.5 VWF F3
37 dieulafoy lesion 10.5 VWF F2
38 pulmonary embolism and infarction 10.5 F3 F2
39 purpura fulminans 10.5 SERPINC1 F3 F2
40 acute dacryoadenitis 10.5 CRP ACE
41 sticky platelet syndrome 10.5 SERPINE1 SERPINC1
42 puerperal pulmonary embolism 10.5 SERPINC1 F10
43 peptic ulcer perforation 10.5 CRP ALB
44 dysfibrinogenemia, congenital 10.5 SERPINC1 PLAT F2
45 cardiogenic shock 10.5 PLAT NPPB
46 acalculous cholecystitis 10.5 F2 CRP ALB
47 splenic abscess 10.5 F2 CRP ALB
48 subdural empyema 10.5 F2 CRP
49 hepatoportal sclerosis 10.5 F2 ACE
50 ascending cholangitis 10.5 F2 CRP ALB

Graphical network of the top 20 diseases related to Pulmonary Artery Disease:



Diseases related to Pulmonary Artery Disease

Symptoms & Phenotypes for Pulmonary Artery Disease

MGI Mouse Phenotypes related to Pulmonary Artery Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.16 ACE ALB CRP F10 F2 F3
2 homeostasis/metabolism MP:0005376 10.09 ACE ALB CRP F10 F2 F3
3 mortality/aging MP:0010768 9.83 ACE ALB F10 F2 F3 F7
4 muscle MP:0005369 9.23 ALB F2 F3 PLAT SERPINC1 TNNI3

Drugs & Therapeutics for Pulmonary Artery Disease

Search Clinical Trials , NIH Clinical Center for Pulmonary Artery Disease

Genetic Tests for Pulmonary Artery Disease

Genetic tests related to Pulmonary Artery Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Pulmonary Artery 29

Anatomical Context for Pulmonary Artery Disease

MalaCards organs/tissues related to Pulmonary Artery Disease:

40
Heart, Endothelial, Smooth Muscle

Publications for Pulmonary Artery Disease

Articles related to Pulmonary Artery Disease:

(show all 38)
# Title Authors PMID Year
1
Outcomes in Patients with Alagille Syndrome and Complex Pulmonary Artery Disease. 61
32980376 2021
2
Preclinical study of a self-expanding pulmonary valve for the treatment of pulmonary valve disease. 61
33365146 2020
3
Surgical treatment for a pulmonary artery aneurysm with stenosis of the quadricuspid pulmonary valve. 61
32949125 2020
4
Acute Pulmonary Embolism: Imaging Techniques, Findings, Endovascular Treatment and Differential Diagnoses. 61
31137046 2020
5
Peripheral and pulmonary artery disease: an update on under-regognized cardiovascular issues. 61
33215655 2019
6
State-of-the-art pulmonary arterial imaging - Part 2. 61
29806799 2018
7
Isolated left-sided partial anomalous pulmonary venous connection in a child. 61
28902647 2017
8
Imaging in vascular diseases of the lung. 61
27270181 2016
9
Predictive value of NT-proBNP combined with exercise capacity variables in pulmonary artery disease: Insights from a Spanish cohort. 61
25804462 2015
10
C-reactive protein induces pulmonary artery smooth cell proliferation via modulation of ERK1/2, Akt and NF-kappaB pathways. 61
25185422 2014
11
Comorbidities of COPD. 61
24293462 2013
12
Surgical outcome of two difficult cases with predominant proximal pulmonary artery lesions of chronic thromboembolic pulmonary hypertension. 61
23555449 2011
13
Orally active prostacyclin analogue for cardiovascular disease. 61
20357744 2010
14
Intimal sarcoma of the pulmonary artery: a report of two cases. 61
20058517 2009
15
HIV Nef protein causes endothelial dysfunction in porcine pulmonary arteries and human pulmonary artery endothelial cells. 61
19540523 2009
16
Pulmonary hypertension in patients with end-stage renal disease undergoing renal transplantation. 61
19765426 2009
17
Antithrombotic therapy for peripheral artery occlusive disease: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). 61
18574279 2008
18
Highly variable cutis laxa resulting from a dominant splicing mutation of the elastin gene. 61
18348261 2008
19
Japanese single-center experience of surgery for chronic thromboembolic pulmonary hypertension. 61
16863777 2006
20
Diagnosis of perfusion abnormality of the pulmonary artery in Takayasu's arteritis using contrast-enhanced MR perfusion imaging. 61
16416104 2006
21
PDGF and IL-1beta upregulate cofilin and LIMK2 in canine cultured pulmonary artery smooth muscle cells. 61
15467300 2004
22
Reconstruction of bilateral branch pulmonary artery stenosis caused by Takayasu's aortitis. 61
15277740 2004
23
[Magnetic resonance imaging and lung perfusion scintigraphy in tetralogy of Fallot following surgery]. 61
14757020 2004
24
[A case of an advanced aged Eisenmenger's syndrome]. 61
11201176 2000
25
Inhaled nitric oxide. 61
10709861 2000
26
[Pulmonary thrombendarteriectomy]. 61
19479392 1997
27
Cardiovascular applications of magnetic resonance flow and velocity measurements. 61
8851410 1996
28
Morbidity risk assessment in the surgically anemic patient. 61
8546245 1995
29
Pulmonary MR angiography at 1.0 T: early results with k-space segmented and post-contrast TurboFLASH two-dimensional time-of-flight sequences. 61
7556263 1995
30
Pulmonary artery disease in Takayasu's arteritis: angiographic findings. 61
1352939 1992
31
Treatment of hypertension: the place of angiotensin-converting enzyme inhibitors in the nineties. 61
1283428 1992
32
[Severe pulmonary artery involvement of Takayasu arteritis. 3 cases and review of the literature]. 61
1680319 1991
33
Right-to-left shunting through a patent foramen ovale caused by pulmonary hypertension associated with rheumatoid arthritis and Sjögren's syndrome: a case report. 61
2278405 1990
34
Incidence of pulmonary embolism in elderly patients newly admitted to an acute geriatric unit: a prospective study. 61
2311328 1990
35
[Surgery of congenital acyanotic cardiac malformations (author's transl)]. 61
721031 1978
36
Pulmonary artery involvement in Takayasu's arteritis. 61
14812 1975
37
Vaso-occlusive pulmonary artery disease in the cat. A preliminary report. 61
4531189 1972
38
[An abnormality of the pulmonary artery]. 61
13259605 1955

Variations for Pulmonary Artery Disease

Expression for Pulmonary Artery Disease

Search GEO for disease gene expression data for Pulmonary Artery Disease.

Pathways for Pulmonary Artery Disease

Pathways related to Pulmonary Artery Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.05 VWF SERPINE1 SERPINC1 SERPINA3 SELP PLG
2
Show member pathways
12.61 SERPINC1 F7 F3 F2 F10
3
Show member pathways
12.19 SERPINE1 SERPINA3 PLG PLAT F7 F2
4 11.77 VWF SERPINE1 SERPINC1 PLG PLAT F7
5
Show member pathways
11.52 VWF SERPINE1 SERPINC1 PLG PLAT PF4
6 11.42 SERPINE1 PLG PLAT
7 11.29 SELP PLG PLAT
8 10.94 PLG PLAT ACE
9 10.8 VKORC1 F7 F2 F10
10 10.66 SERPINE1 PLG PLAT

GO Terms for Pulmonary Artery Disease

Cellular components related to Pulmonary Artery Disease according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 10.15 VWF SERPINE1 SERPINC1 SERPINA3 PLG PLAT
2 extracellular region GO:0005576 10.03 VWF SERPINE1 SERPINC1 SERPINA3 PLG PLAT
3 endoplasmic reticulum lumen GO:0005788 9.85 SERPINC1 F7 F2 F10 ALB
4 platelet alpha granule lumen GO:0031093 9.73 VWF SERPINE1 SERPINA3 PLG PF4 ALB
5 blood microparticle GO:0072562 9.72 SERPINC1 SERPINA3 PLG F2 ALB
6 collagen-containing extracellular matrix GO:0062023 9.65 VWF SERPINE1 SERPINC1 SERPINA3 PLG PLAT
7 extracellular space GO:0005615 9.55 VWF SERPINE1 SERPINC1 SERPINA3 SELP PLG
8 troponin complex GO:0005861 9.51 TNNT2 TNNI3
9 cardiac myofibril GO:0097512 9.48 TNNT2 TNNI3
10 cardiac Troponin complex GO:1990584 9.43 TNNT2 TNNI3
11 intrinsic component of external side of plasma membrane GO:0031233 9.4 F3 F10
12 serine-type peptidase complex GO:1905286 9.37 F7 F3

Biological processes related to Pulmonary Artery Disease according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.99 PLG PLAT F7 F2 F10 ACE
2 cellular protein metabolic process GO:0044267 9.84 SERPINC1 PLG F2 ALB
3 positive regulation of protein kinase B signaling GO:0051897 9.83 MIR126 F7 F3 F10
4 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.74 SELP MIR126 F2
5 platelet degranulation GO:0002576 9.7 VWF SERPINE1 SERPINA3 SELP PLG PF4
6 acute-phase response GO:0006953 9.65 SERPINA3 F2 CRP
7 negative regulation of proteolysis GO:0045861 9.63 PLAT MIR126 F2
8 positive regulation of blood coagulation GO:0030194 9.61 SERPINE1 F7 F2
9 blood coagulation GO:0007596 9.61 VWF VKORC1 SERPINC1 PLG PLAT F7
10 regulation of blood coagulation GO:0030193 9.58 VKORC1 SERPINC1 F2
11 positive regulation of positive chemotaxis GO:0050927 9.56 F7 F3
12 fibrinolysis GO:0042730 9.56 SERPINE1 PLG PLAT F2
13 negative regulation of ATPase activity GO:0032780 9.55 TNNT2 TNNI3
14 negative regulation of fibrinolysis GO:0051918 9.54 SERPINE1 PLG F2
15 blood coagulation, extrinsic pathway GO:0007598 9.5 F7 F3 F10
16 positive regulation of platelet-derived growth factor receptor signaling pathway GO:0010641 9.49 F7 F3
17 hemostasis GO:0007599 9.17 VWF SERPINC1 PLG F7 F3 F2

Molecular functions related to Pulmonary Artery Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.41 VWF VKORC1 TNNT2 TNNI3 SERPINE1 SERPINC1
2 peptidase activity GO:0008233 9.8 PLG PLAT F7 F2 F10 ACE
3 heparin binding GO:0008201 9.71 SERPINC1 SELP PF4 F2
4 signaling receptor binding GO:0005102 9.63 SERPINE1 PLG PLAT NPPB F7 F2
5 protease binding GO:0002020 9.56 VWF SERPINE1 SERPINC1 F3
6 troponin C binding GO:0030172 9.37 TNNT2 TNNI3
7 serine-type peptidase activity GO:0008236 9.35 PLG PLAT F7 F2 F10
8 serine-type endopeptidase activity GO:0004252 9.1 PLG PLAT F7 F3 F2 F10

Sources for Pulmonary Artery Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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