MCID: PLM180
MIFTS: 34

Pulmonary Artery Disease

Categories: Cardiovascular diseases, Respiratory diseases

Aliases & Classifications for Pulmonary Artery Disease

MalaCards integrated aliases for Pulmonary Artery Disease:

Name: Pulmonary Artery Disease 12 15
Abnormality of the Pulmonary Artery 29

Classifications:



External Ids:

Disease Ontology 12 DOID:60001

Summaries for Pulmonary Artery Disease

Disease Ontology : 12 A disease that is located in the lungs.

MalaCards based summary : Pulmonary Artery Disease, also known as abnormality of the pulmonary artery, is related to arteries, anomalies of and prothrombin deficiency. An important gene associated with Pulmonary Artery Disease is EPHA2 (EPH Receptor A2), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. Affiliated tissues include lung, heart and liver, and related phenotypes are Increased shRNA abundance and homeostasis/metabolism

Wikipedia : 76 A pulmonary artery is an artery in the pulmonary circulation that carries deoxygenated blood from the... more...

Related Diseases for Pulmonary Artery Disease

Diseases related to Pulmonary Artery Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 157)
# Related Disease Score Top Affiliating Genes
1 arteries, anomalies of 29.6 ALB F3 PLAT PLG SERPINC1 TNNI3
2 prothrombin deficiency 10.3 F2 F3
3 fibrinolytic defect 10.3 PLAT SERPINC1
4 pulmonary artery leiomyosarcoma 10.3 EPHA2 PLG
5 argentine hemorrhagic fever 10.3 PLAT SERPINC1
6 ligneous conjunctivitis 10.3 PLAT PLG
7 conjugate gaze palsy 10.3 F3 PLG
8 platelet aggregation, spontaneous 10.3 PLAT SERPINC1
9 inferior myocardial infarction 10.2 PLAT PLG
10 central retinal artery occlusion 10.2 PLAT PLG
11 qualitative platelet defect 10.2 F2 F3
12 posterior myocardial infarction 10.2 PLAT SERPINC1
13 encephalopathy, familial, with neuroserpin inclusion bodies 10.2 PLAT SERPINC1
14 alpha-2-plasmin inhibitor deficiency 10.2 F2 PLG SERPINC1
15 alcohol-related birth defect 10.2 F2 F3
16 anterior spinal artery syndrome 10.2 F2 PLG SERPINC1
17 hantavirus pulmonary syndrome 10.2 F2 F3
18 cerebral falx meningioma 10.2 F2 F3 PLG
19 purpura 10.2 F2 F3 SERPINC1
20 coronary thrombosis 10.2 F3 PLAT SERPINC1
21 purpura fulminans 10.2 F2 F3 SERPINC1
22 antipyrine metabolism 10.2 ALB F2
23 non-a-e hepatitis 10.2 ALB F2
24 inherited blood coagulation disease 10.2 F2 F3 SERPINC1
25 von willebrand disease, type 1 10.2 F2 F3
26 anterior cranial fossa meningioma 10.2 F2 F3 PLG
27 subendocardial myocardial infarction 10.2 F2 SERPINC1
28 mesenteric vascular occlusion 10.2 F2 MTHFR
29 factor xi deficiency 10.2 F2 F3 SERPINC1
30 endocardium disease 10.2 F2 F3 PLG
31 epstein-barr virus hepatitis 10.2 ALB F2
32 thrombocytosis 10.2 F2 F3 SERPINC1
33 ischemic neuropathy 10.2 F2 MTHFR
34 abdominal tuberculosis 10.2 ALB F2
35 paracetamol poisoning 10.2 F2 F5
36 heparin-induced thrombocytopenia 10.2 F10 F3 SERPINC1
37 sneddon syndrome 10.2 F2 SERPINC1
38 sticky platelet syndrome 10.2 F5 SERPINC1
39 carotid artery thrombosis 10.2 F10 F3 PLAT
40 hepatic tuberculosis 10.1 ALB F2
41 acquired hemophilia a 10.1 F3 F5
42 kwashiorkor 10.1 ALB F2
43 intracranial embolism 10.1 F2 PLAT PLG SERPINC1
44 hemoglobin e disease 10.1 F2 F5
45 hepatic coma 10.1 ALB F2
46 carotid artery dissection 10.1 MTHFR PLAT PLG
47 grange syndrome 10.1 F3 MTHFR PLAT
48 hepatic veno-occlusive disease 10.1 F3 PLAT PLG SERPINC1
49 intestinal impaction 10.1 F2 F3 PLG SERPINC1
50 lemierre's syndrome 10.1 F3 MTHFR PLG

Graphical network of the top 20 diseases related to Pulmonary Artery Disease:



Diseases related to Pulmonary Artery Disease

Symptoms & Phenotypes for Pulmonary Artery Disease

GenomeRNAi Phenotypes related to Pulmonary Artery Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 8.92 EPHA2 F5 MTHFR TNNI3

MGI Mouse Phenotypes related to Pulmonary Artery Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.07 ALB EPHA2 F10 F2 F3 F5
2 cardiovascular system MP:0005385 10.06 EPHA2 F10 F2 F3 F5 FABP3
3 mortality/aging MP:0010768 9.8 ALB EPHA2 F10 F2 F3 F5
4 liver/biliary system MP:0005370 9.7 ALB F5 FABP3 MTHFR PLG PPARGC1B
5 vision/eye MP:0005391 9.23 EPHA2 F3 FABP3 MFRP MTHFR PLAT

Drugs & Therapeutics for Pulmonary Artery Disease

Search Clinical Trials , NIH Clinical Center for Pulmonary Artery Disease

Genetic Tests for Pulmonary Artery Disease

Genetic tests related to Pulmonary Artery Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Pulmonary Artery 29

Anatomical Context for Pulmonary Artery Disease

MalaCards organs/tissues related to Pulmonary Artery Disease:

41
Lung, Heart, Liver, Spinal Cord, Placenta

Publications for Pulmonary Artery Disease

Articles related to Pulmonary Artery Disease:

# Title Authors Year
1
Predictive value of NT-proBNP combined with exercise capacity variables in pulmonary artery disease: Insights from a Spanish cohort. ( 25804462 )
2015
2
Pulmonary artery disease in Takayasu's arteritis: angiographic findings. ( 1352939 )
1992
3
Vaso-occlusive pulmonary artery disease in the cat. A preliminary report. ( 4531189 )
1972

Variations for Pulmonary Artery Disease

Expression for Pulmonary Artery Disease

Search GEO for disease gene expression data for Pulmonary Artery Disease.

Pathways for Pulmonary Artery Disease

Pathways related to Pulmonary Artery Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.94 ALB F10 F2 F3 F5 PLAT
2
Show member pathways
12.44 F10 F2 F3 F5 SERPINC1
3
Show member pathways
11.89 ALB F2 MTHFR PLAT PLG
4
Show member pathways
11.71 F2 PLAT PLG
5
Show member pathways
11.7 F10 F2 F3 F5 PLAT PLG
6 11.31 F10 F2 F3 F5 PLAT PLG
7 10.84 PLAT PLG
8 10.78 F2 PLG
9 10.58 F10 F2
10 10.48 PLAT PLG

GO Terms for Pulmonary Artery Disease

Cellular components related to Pulmonary Artery Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen-containing extracellular matrix GO:0062023 9.67 F3 PLAT PLG SERPINC1
2 platelet alpha granule lumen GO:0031093 9.5 ALB F5 PLG
3 blood microparticle GO:0072562 9.46 ALB F2 PLG SERPINC1
4 endoplasmic reticulum lumen GO:0005788 9.35 ALB F10 F2 F5 SERPINC1
5 extracellular space GO:0005615 9.28 ALB F10 F2 F3 F5 FABP3
6 intrinsic component of external side of plasma membrane GO:0031233 9.26 F10 F3
7 extracellular region GO:0005576 10.01 ALB F10 F2 F3 F5 PLAT

Biological processes related to Pulmonary Artery Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 9.61 ALB F5 PLG
2 cellular protein metabolic process GO:0044267 9.55 ALB F2 F5 PLG SERPINC1
3 blood coagulation GO:0007596 9.5 F10 F2 F3 F5 PLAT PLG
4 negative regulation of proteolysis GO:0045861 9.48 F2 PLAT
5 response to fatty acid GO:0070542 9.46 FABP3 TBXAS1
6 fibrinolysis GO:0042730 9.43 F2 PLAT PLG
7 regulation of blood coagulation GO:0030193 9.4 F2 SERPINC1
8 negative regulation of fibrinolysis GO:0051918 9.37 F2 PLG
9 blood coagulation, extrinsic pathway GO:0007598 9.32 F10 F3
10 hemostasis GO:0007599 9.1 F10 F2 F3 F5 PLG SERPINC1

Molecular functions related to Pulmonary Artery Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type peptidase activity GO:0008236 9.26 F10 F2 PLAT PLG
2 serine-type endopeptidase activity GO:0004252 9.02 F10 F2 F3 PLAT PLG

Sources for Pulmonary Artery Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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