MCID: PLM180
MIFTS: 34

Pulmonary Artery Disease

Categories: Cardiovascular diseases, Respiratory diseases

Aliases & Classifications for Pulmonary Artery Disease

MalaCards integrated aliases for Pulmonary Artery Disease:

Name: Pulmonary Artery Disease 12 15
Abnormality of the Pulmonary Artery 30

Classifications:



External Ids:

Disease Ontology 12 DOID:60001

Summaries for Pulmonary Artery Disease

Disease Ontology : 12 A disease that is located in the lungs.

MalaCards based summary : Pulmonary Artery Disease, also known as abnormality of the pulmonary artery, is related to arteries, anomalies of and occlusion precerebral artery. An important gene associated with Pulmonary Artery Disease is EPHA2 (EPH Receptor A2), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. Affiliated tissues include lung and heart, and related phenotypes are Increased shRNA abundance and cardiovascular system

Wikipedia : 77 A pulmonary artery is an artery in the pulmonary circulation that carries deoxygenated blood from the... more...

Related Diseases for Pulmonary Artery Disease

Diseases related to Pulmonary Artery Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 176)
# Related Disease Score Top Affiliating Genes
1 arteries, anomalies of 28.8 ALB F3 PLAT PLG SERPINC1 SERPINE1
2 occlusion precerebral artery 10.5 PLAT PLG
3 sneddon syndrome 10.5 F2 SERPINC1
4 vascular hemostatic disease 10.5 F2 F3
5 prothrombin deficiency 10.5 F2 F3
6 pulmonary artery leiomyosarcoma 10.4 EPHA2 PLG
7 ligneous conjunctivitis 10.4 PLAT PLG
8 conjugate gaze palsy 10.4 F3 PLG
9 anteroseptal myocardial infarction 10.4 ALB PLG
10 inferior myocardial infarction 10.4 PLAT PLG
11 platelet aggregation, spontaneous 10.4 PLAT SERPINC1
12 central retinal artery occlusion 10.4 PLAT PLG
13 qualitative platelet defect 10.3 F2 F3
14 alpha-2-plasmin inhibitor deficiency 10.3 F2 PLG SERPINC1
15 anterior spinal artery syndrome 10.3 F2 PLG SERPINC1
16 cerebral falx meningioma 10.3 F2 F3 PLG
17 mesenteric vascular occlusion 10.3 F2 MTHFR
18 purpura 10.3 F2 F3 SERPINC1
19 purpura fulminans 10.3 F2 F3 SERPINC1
20 antipyrine metabolism 10.3 ALB F2
21 non-a-e hepatitis 10.3 ALB F2
22 anterior cranial fossa meningioma 10.3 F2 F3 PLG
23 inherited blood coagulation disease 10.3 F2 F3 SERPINC1
24 factor xi deficiency 10.3 F2 F3 SERPINC1
25 endocardium disease 10.3 F2 F3 PLG
26 epstein-barr virus hepatitis 10.3 ALB F2
27 factor viii deficiency 10.3 F2 F5
28 alcohol-related birth defect 10.3 F2 F3
29 heparin-induced thrombocytopenia 10.3 F10 F3 SERPINC1
30 posterior myocardial infarction 10.3 PLAT SERPINC1
31 thrombocytosis 10.3 F2 F3 SERPINC1
32 abdominal tuberculosis 10.2 ALB F2
33 ischemic neuropathy 10.2 F2 MTHFR
34 hantavirus pulmonary syndrome 10.2 F2 F3
35 carotid artery dissection 10.2 MTHFR PLAT PLG
36 grange syndrome 10.2 F3 MTHFR PLAT
37 intracranial embolism 10.2 F2 PLAT PLG SERPINC1
38 burns 10.2 ALB SERPINC1
39 hemorrhagic fever 10.2 ALB F2 SERPINC1
40 factor vii deficiency 10.2 F10 F2 F3
41 intestinal impaction 10.2 F2 F3 PLG SERPINC1
42 giant hemangioma 10.2 F2 F3 PLG SERPINC1
43 esophageal varix 10.2 ALB F2 SERPINC1
44 hepatic tuberculosis 10.2 ALB F2
45 paracetamol poisoning 10.2 F2 F5
46 korean hemorrhagic fever 10.2 F2 F3 PLG SERPINC1
47 afibrinogenemia, congenital 10.2 F2 F3 PLAT SERPINC1
48 hypersplenism 10.2 ALB F2 SERPINC1
49 splenic disease 10.2 ALB F2 F3
50 kwashiorkor 10.2 ALB F2

Graphical network of the top 20 diseases related to Pulmonary Artery Disease:



Diseases related to Pulmonary Artery Disease

Symptoms & Phenotypes for Pulmonary Artery Disease

GenomeRNAi Phenotypes related to Pulmonary Artery Disease according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 8.92 EPHA2 F5 MTHFR TNNI3

MGI Mouse Phenotypes related to Pulmonary Artery Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.25 EPHA2 F10 F2 F3 F5 FABP3
2 homeostasis/metabolism MP:0005376 10.24 ALB EPHA2 F10 F2 F3 F5
3 hematopoietic system MP:0005397 10.06 F2 F3 PLAT PLG PPARGC1B SERPINC1
4 mortality/aging MP:0010768 10.06 ALB EPHA2 F10 F2 F3 F5
5 integument MP:0010771 9.87 F2 F3 F5 MTHFR PLAT PLG
6 liver/biliary system MP:0005370 9.86 ALB F5 FABP3 MTHFR PLG PPARGC1B
7 respiratory system MP:0005388 9.5 F2 F3 PLAT PLG PPARGC1B SERPINE1
8 vision/eye MP:0005391 9.17 EPHA2 F3 FABP3 MTHFR PLAT PLG

Drugs & Therapeutics for Pulmonary Artery Disease

Search Clinical Trials , NIH Clinical Center for Pulmonary Artery Disease

Genetic Tests for Pulmonary Artery Disease

Genetic tests related to Pulmonary Artery Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Pulmonary Artery 30

Anatomical Context for Pulmonary Artery Disease

MalaCards organs/tissues related to Pulmonary Artery Disease:

42
Lung, Heart

Publications for Pulmonary Artery Disease

Articles related to Pulmonary Artery Disease:

# Title Authors Year
1
Predictive value of NT-proBNP combined with exercise capacity variables in pulmonary artery disease: Insights from a Spanish cohort. ( 25804462 )
2015
2
Pulmonary artery disease in Takayasu's arteritis: angiographic findings. ( 1352939 )
1992
3
Vaso-occlusive pulmonary artery disease in the cat. A preliminary report. ( 4531189 )
1972

Variations for Pulmonary Artery Disease

Expression for Pulmonary Artery Disease

Search GEO for disease gene expression data for Pulmonary Artery Disease.

Pathways for Pulmonary Artery Disease

Pathways related to Pulmonary Artery Disease according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.99 ALB F10 F2 F3 F5 PLAT
2
Show member pathways
12.55 F10 F2 F3 F5 SERPINC1
3
Show member pathways
11.97 ALB F2 MTHFR PLAT PLG SERPINE1
4
Show member pathways
11.76 F10 F2 F3 F5 PLAT PLG
5
Show member pathways
11.75 F2 PLAT PLG
6 11.72 F3 PLG SERPINE1
7 11.37 PLAT PLG SERPINE1
8 11.37 F10 F2 F3 F5 PLAT PLG
9 10.87 PLAT PLG
10 10.82 F2 PLG
11 10.72 F10 F2 VKORC1
12 10.61 PLAT PLG SERPINE1

GO Terms for Pulmonary Artery Disease

Cellular components related to Pulmonary Artery Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.65 ALB F10 F2 F5 SERPINC1
2 blood microparticle GO:0072562 9.62 ALB F2 PLG SERPINC1
3 collagen-containing extracellular matrix GO:0062023 9.55 F3 PLAT PLG SERPINC1 SERPINE1
4 intrinsic component of external side of plasma membrane GO:0031233 9.37 F10 F3
5 extracellular space GO:0005615 9.32 ALB F10 F2 F3 F5 FABP3
6 platelet alpha granule lumen GO:0031093 9.26 ALB F5 PLG SERPINE1
7 extracellular region GO:0005576 10.06 ALB F10 F2 F3 F5 PLAT

Biological processes related to Pulmonary Artery Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.77 ALB F2 F5 PLG SERPINC1
2 platelet degranulation GO:0002576 9.71 ALB F5 PLG SERPINE1
3 response to fatty acid GO:0070542 9.48 FABP3 TBXAS1
4 positive regulation of blood coagulation GO:0030194 9.46 F2 SERPINE1
5 fibrinolysis GO:0042730 9.46 F2 PLAT PLG SERPINE1
6 blood coagulation, extrinsic pathway GO:0007598 9.43 F10 F3
7 negative regulation of fibrinolysis GO:0051918 9.43 F2 PLG SERPINE1
8 hemostasis GO:0007599 9.43 F10 F2 F3 F5 PLG SERPINC1
9 regulation of blood coagulation GO:0030193 9.32 F2 SERPINC1
10 blood coagulation GO:0007596 9.23 F10 F2 F3 F5 PLAT PLG

Molecular functions related to Pulmonary Artery Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.33 F3 SERPINC1 SERPINE1
2 serine-type peptidase activity GO:0008236 9.26 F10 F2 PLAT PLG
3 serine-type endopeptidase activity GO:0004252 9.02 F10 F2 F3 PLAT PLG

Sources for Pulmonary Artery Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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