MCID: PLM180
MIFTS: 35

Pulmonary Artery Disease

Categories: Cardiovascular diseases, Respiratory diseases

Aliases & Classifications for Pulmonary Artery Disease

MalaCards integrated aliases for Pulmonary Artery Disease:

Name: Pulmonary Artery Disease 12 15
Abnormality of the Pulmonary Artery 29

Classifications:



External Ids:

Disease Ontology 12 DOID:60001

Summaries for Pulmonary Artery Disease

Disease Ontology : 12 An artery disease that is located in the lungs.

MalaCards based summary : Pulmonary Artery Disease, also known as abnormality of the pulmonary artery, is related to heart septal defect and pericarditis. An important gene associated with Pulmonary Artery Disease is SERPINC1 (Serpin Family C Member 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. Affiliated tissues include heart, lung and kidney, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 74 A pulmonary artery is an artery in the pulmonary circulation that carries deoxygenated blood from the... more...

Related Diseases for Pulmonary Artery Disease

Diseases related to Pulmonary Artery Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 416)
# Related Disease Score Top Affiliating Genes
1 heart septal defect 30.5 TNNT2 TNNI3 F2
2 pericarditis 30.0 TNNT2 TNNI3 NPPB CRP ALB ACE
3 congestive heart failure 29.9 TNNT2 TNNI3 NPPB CRP ALB ACE
4 tricuspid valve insufficiency 29.9 TNNI3 NPPB F3 F2 CRP ALB
5 tetralogy of fallot 29.9 TNNT2 TNNI3 NPPB MTHFR CRP ACE
6 arteriosclerosis 29.7 THBD SERPINE1 SERPINC1 SELP F3 CRP
7 arteries, anomalies of 29.4 VWF TNNT2 TNNI3 SERPINE1 SELP PLG
8 pulmonary hypertension 29.2 VWF THBD SERPINE1 SERPINC1 SELP PLG
9 atrial heart septal defect 29.1 TNNT2 TNNI3 SERPINC1 PLG PLAT NPPB
10 pulmonary embolism 28.3 VWF TNNT2 TNNI3 THBD SERPINE1 SERPINC1
11 orbital osteomyelitis 10.7 F2 CRP
12 non-a-e hepatitis 10.7 F2 ALB
13 antipyrine metabolism 10.7 F2 ALB
14 small intestine diverticulitis 10.7 F2 CRP
15 gastric hemangioma 10.7 F3 F2
16 chronic duodenal ileus 10.7 CRP ALB
17 vulvar angiokeratoma 10.7 SERPINC1 F3
18 basal ganglia cerebrovascular disease 10.7 PLG PLAT
19 anterior cerebral artery infarction 10.7 PLG PLAT
20 giant hemangioma 10.7 SERPINC1 F3 F2
21 volkmann contracture 10.7 SERPINC1 F3 F2
22 renal pelvis squamous cell carcinoma 10.7 F3 F2 CRP
23 cavernous sinus thrombosis 10.7 SERPINC1 F2 CRP
24 ligneous conjunctivitis 10.7 PLG PLAT
25 emphysematous cholecystitis 10.7 F3 F2 CRP
26 hemopericardium 10.7 PLG F3 F2
27 congenitally corrected transposition of the great arteries 10.7 TNNT2 NPPB
28 waterhouse-friderichsen syndrome 10.7 SERPINC1 F2
29 acquired hemophilia 10.7 F3 F10
30 prothrombin deficiency, congenital 10.7 SERPINC1 F2 F10
31 prothrombin-related thrombophilia 10.7 MTHFR F2
32 hepatic coma 10.7 SERPINC1 F2 ALB
33 necrotizing gastritis 10.7 F2 CRP ALB
34 papillary adenofibroma 10.7 VWF F3 F2
35 splenic abscess 10.7 F2 CRP ALB
36 purpura fulminans 10.7 SERPINC1 F3 F2
37 encephalopathy, familial, with neuroserpin inclusion bodies 10.7 SERPINC1 PLG PLAT
38 ascending cholangitis 10.7 F2 CRP ALB
39 acalculous cholecystitis 10.7 F2 CRP ALB
40 epidural abscess 10.7 F3 CRP ALB
41 hepatoportal sclerosis 10.7 F2 ACE
42 mediastinum teratoma 10.7 CRP ACE
43 mediastinitis 10.7 F2 CRP ALB
44 unilateral absence of a pulmonary artery 10.7 VWF THBD
45 acute cholangitis 10.6 F2 CRP ALB
46 abdominal tuberculosis 10.6 F2 CRP ALB
47 aspiration pneumonitis 10.6 F3 CRP ALB
48 paralytic ileus 10.6 F2 CRP ALB
49 phenytoin toxicity 10.6 VKORC1 ALB
50 sticky platelet syndrome 10.6 SERPINE1 SERPINC1

Graphical network of the top 20 diseases related to Pulmonary Artery Disease:



Diseases related to Pulmonary Artery Disease

Symptoms & Phenotypes for Pulmonary Artery Disease

MGI Mouse Phenotypes related to Pulmonary Artery Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.36 ACE ALB CRP F10 F2 F3
2 homeostasis/metabolism MP:0005376 10.32 ACE ALB CRP F10 F2 F3
3 hematopoietic system MP:0005397 10.18 ACE F2 F3 PF4 PLAT PLG
4 immune system MP:0005387 10.1 ACE ALB CRP F2 F3 PLAT
5 mortality/aging MP:0010768 10.09 ACE ALB F10 F2 F3 F7
6 liver/biliary system MP:0005370 9.86 ACE ALB MTHFR PLG SELP SERPINC1
7 nervous system MP:0003631 9.7 F2 F3 MTHFR PLAT PLG SELP
8 respiratory system MP:0005388 9.23 F2 F3 PLAT PLG SELP SERPINE1

Drugs & Therapeutics for Pulmonary Artery Disease

Search Clinical Trials , NIH Clinical Center for Pulmonary Artery Disease

Genetic Tests for Pulmonary Artery Disease

Genetic tests related to Pulmonary Artery Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Pulmonary Artery 29

Anatomical Context for Pulmonary Artery Disease

MalaCards organs/tissues related to Pulmonary Artery Disease:

40
Heart, Lung, Kidney, Brain, Smooth Muscle, Endothelial, Cortex

Publications for Pulmonary Artery Disease

Articles related to Pulmonary Artery Disease:

(show all 34)
# Title Authors PMID Year
1
Acute Pulmonary Embolism: Imaging Techniques, Findings, Endovascular Treatment and Differential Diagnoses. 61
31137046 2020
2
State-of-the-art pulmonary arterial imaging - Part 2. 61
29806799 2018
3
Isolated left-sided partial anomalous pulmonary venous connection in a child. 61
28902647 2017
4
Imaging in vascular diseases of the lung. 61
27270181 2016
5
Predictive value of NT-proBNP combined with exercise capacity variables in pulmonary artery disease: Insights from a Spanish cohort. 61
25804462 2015
6
C-reactive protein induces pulmonary artery smooth cell proliferation via modulation of ERK1/2, Akt and NF-kappaB pathways. 61
25185422 2014
7
Comorbidities of COPD. 61
24293462 2013
8
Surgical outcome of two difficult cases with predominant proximal pulmonary artery lesions of chronic thromboembolic pulmonary hypertension. 61
23555449 2011
9
Orally active prostacyclin analogue for cardiovascular disease. 61
20357744 2010
10
Intimal sarcoma of the pulmonary artery: a report of two cases. 61
20058517 2009
11
HIV Nef protein causes endothelial dysfunction in porcine pulmonary arteries and human pulmonary artery endothelial cells. 61
19540523 2009
12
Pulmonary hypertension in patients with end-stage renal disease undergoing renal transplantation. 61
19765426 2009
13
Antithrombotic therapy for peripheral artery occlusive disease: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). 61
18574279 2008
14
Highly variable cutis laxa resulting from a dominant splicing mutation of the elastin gene. 61
18348261 2008
15
Japanese single-center experience of surgery for chronic thromboembolic pulmonary hypertension. 61
16863777 2006
16
Diagnosis of perfusion abnormality of the pulmonary artery in Takayasu's arteritis using contrast-enhanced MR perfusion imaging. 61
16416104 2006
17
PDGF and IL-1beta upregulate cofilin and LIMK2 in canine cultured pulmonary artery smooth muscle cells. 61
15467300 2004
18
Reconstruction of bilateral branch pulmonary artery stenosis caused by Takayasu's aortitis. 61
15277740 2004
19
[Magnetic resonance imaging and lung perfusion scintigraphy in tetralogy of Fallot following surgery]. 61
14757020 2004
20
[A case of an advanced aged Eisenmenger's syndrome]. 61
11201176 2000
21
Inhaled nitric oxide. 61
10709861 2000
22
[Pulmonary thrombendarteriectomy]. 61
19479392 1997
23
Cardiovascular applications of magnetic resonance flow and velocity measurements. 61
8851410 1996
24
Morbidity risk assessment in the surgically anemic patient. 61
8546245 1995
25
Pulmonary MR angiography at 1.0 T: early results with k-space segmented and post-contrast TurboFLASH two-dimensional time-of-flight sequences. 61
7556263 1995
26
Pulmonary artery disease in Takayasu's arteritis: angiographic findings. 61
1352939 1992
27
Treatment of hypertension: the place of angiotensin-converting enzyme inhibitors in the nineties. 61
1283428 1992
28
[Severe pulmonary artery involvement of Takayasu arteritis. 3 cases and review of the literature]. 61
1680319 1991
29
Right-to-left shunting through a patent foramen ovale caused by pulmonary hypertension associated with rheumatoid arthritis and Sjögren's syndrome: a case report. 61
2278405 1990
30
Incidence of pulmonary embolism in elderly patients newly admitted to an acute geriatric unit: a prospective study. 61
2311328 1990
31
[Surgery of congenital acyanotic cardiac malformations (author's transl)]. 61
721031 1978
32
Pulmonary artery involvement in Takayasu's arteritis. 61
14812 1975
33
Vaso-occlusive pulmonary artery disease in the cat. A preliminary report. 61
4531189 1972
34
[An abnormality of the pulmonary artery]. 61
13259605 1955

Variations for Pulmonary Artery Disease

Expression for Pulmonary Artery Disease

Search GEO for disease gene expression data for Pulmonary Artery Disease.

Pathways for Pulmonary Artery Disease

Pathways related to Pulmonary Artery Disease according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.05 VWF THBD SERPINE1 SERPINC1 SELP PLG
2
Show member pathways
12.64 THBD SERPINC1 F7 F3 F2 F10
3
Show member pathways
12.19 SERPINE1 PLG PLAT MTHFR F7 F2
4
Show member pathways
12.03 THBD SELP PF4 F2
5 11.82 VWF THBD SERPINE1 SERPINC1 PLG PLAT
6
Show member pathways
11.57 VWF THBD SERPINE1 SERPINC1 PLG PLAT
7 11.46 SERPINE1 PLG PLAT
8 11.31 SELP PLG PLAT
9 10.94 PLG PLAT ACE
10 10.8 VKORC1 F7 F2 F10
11 10.66 SERPINE1 PLG PLAT

GO Terms for Pulmonary Artery Disease

Cellular components related to Pulmonary Artery Disease according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10 VWF SERPINE1 SERPINC1 PLG PLAT PF4
2 endoplasmic reticulum lumen GO:0005788 9.8 SERPINC1 F7 F2 F10 ALB
3 blood microparticle GO:0072562 9.76 SERPINC1 PLG F2 ALB
4 platelet alpha granule lumen GO:0031093 9.65 VWF SERPINE1 PLG PF4 ALB
5 collagen-containing extracellular matrix GO:0062023 9.61 VWF SERPINE1 SERPINC1 PLG PLAT PF4
6 extracellular space GO:0005615 9.5 THBD SERPINE1 SERPINC1 SELP PLG PLAT
7 troponin complex GO:0005861 9.49 TNNT2 TNNI3
8 cardiac myofibril GO:0097512 9.48 TNNT2 TNNI3
9 intrinsic component of external side of plasma membrane GO:0031233 9.43 F3 F10
10 cardiac Troponin complex GO:1990584 9.37 TNNT2 TNNI3
11 serine-type peptidase complex GO:1905286 9.32 F7 F3

Biological processes related to Pulmonary Artery Disease according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.97 PLG PLAT F7 F2 F10 ACE
2 cellular protein metabolic process GO:0044267 9.83 SERPINC1 PLG F2 ALB
3 platelet degranulation GO:0002576 9.73 VWF SERPINE1 SELP PLG PF4 ALB
4 blood coagulation GO:0007596 9.65 VWF VKORC1 THBD SERPINC1 PLG PLAT
5 fibrinolysis GO:0042730 9.62 SERPINE1 PLG PLAT F2
6 positive regulation of blood coagulation GO:0030194 9.61 SERPINE1 F7 F2
7 regulation of blood coagulation GO:0030193 9.58 VKORC1 SERPINC1 F2
8 positive regulation of positive chemotaxis GO:0050927 9.55 F7 F3
9 negative regulation of ATPase activity GO:0032780 9.54 TNNT2 TNNI3
10 blood coagulation, extrinsic pathway GO:0007598 9.54 F7 F3 F10
11 negative regulation of platelet activation GO:0010544 9.51 THBD F2
12 trans-synaptic signaling by BDNF, modulating synaptic transmission GO:0099183 9.48 PLG PLAT
13 positive regulation of platelet-derived growth factor receptor signaling pathway GO:0010641 9.46 F7 F3
14 negative regulation of fibrinolysis GO:0051918 9.46 THBD SERPINE1 PLG F2
15 hemostasis GO:0007599 9.23 VWF THBD SERPINC1 PLG F7 F3

Molecular functions related to Pulmonary Artery Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.88 PLG PLAT F7 F2 F10 ACE
2 calcium ion binding GO:0005509 9.8 TNNT2 THBD SELP F7 F2 F10
3 heparin binding GO:0008201 9.73 SERPINC1 SELP PF4 F2
4 endopeptidase activity GO:0004175 9.63 PLG F7 ACE
5 signaling receptor binding GO:0005102 9.63 SERPINE1 PLG PLAT NPPB F7 F2
6 protease binding GO:0002020 9.62 VWF SERPINE1 SERPINC1 F3
7 troponin C binding GO:0030172 9.37 TNNT2 TNNI3
8 serine-type peptidase activity GO:0008236 9.35 PLG PLAT F7 F2 F10
9 serine-type endopeptidase activity GO:0004252 9.1 PLG PLAT F7 F3 F2 F10

Sources for Pulmonary Artery Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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