MCID: PLM180
MIFTS: 33

Pulmonary Artery Disease

Categories: Cardiovascular diseases, Respiratory diseases

Aliases & Classifications for Pulmonary Artery Disease

MalaCards integrated aliases for Pulmonary Artery Disease:

Name: Pulmonary Artery Disease 12 15
Abnormality of the Pulmonary Artery 29

Classifications:



External Ids:

Disease Ontology 12 DOID:60001

Summaries for Pulmonary Artery Disease

Disease Ontology : 12 An artery disease that is located in the lungs.

MalaCards based summary : Pulmonary Artery Disease, also known as abnormality of the pulmonary artery, is related to arteriosclerosis and arteries, anomalies of. An important gene associated with Pulmonary Artery Disease is PLAT (Plasminogen Activator, Tissue Type), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. Affiliated tissues include lung, heart and endothelial, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 75 A pulmonary artery is an artery in the pulmonary circulation that carries deoxygenated blood from the... more...

Related Diseases for Pulmonary Artery Disease

Diseases related to Pulmonary Artery Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 210)
# Related Disease Score Top Affiliating Genes
1 arteriosclerosis 29.3 SERPINE1 F3 CRP
2 arteries, anomalies of 27.0 TNNI3 SERPINE1 SERPINC1 PLG PLAT NPPB
3 pulmonary embolism 23.9 TNNT2 TNNI3 SERPINE1 SERPINC1 PLAT NPPB
4 prothrombin deficiency 10.8 F3 F2
5 ligneous conjunctivitis 10.7 PLG PLAT
6 conjugate gaze palsy 10.7 PLG F3
7 central retinal artery occlusion 10.6 PLG PLAT
8 platelet aggregation, spontaneous 10.6 SERPINC1 PLAT
9 mesenteric vascular occlusion 10.6 MTHFR F2
10 non-a-e hepatitis 10.6 F2 ALB
11 antipyrine metabolism 10.6 F2 ALB
12 qualitative platelet defect 10.6 F3 F2
13 epstein-barr virus hepatitis 10.6 F2 ALB
14 alpha-2-plasmin inhibitor deficiency 10.6 SERPINC1 PLG F2
15 anterior spinal artery syndrome 10.6 SERPINC1 PLG F2
16 cerebral falx meningioma 10.6 PLG F3 F2
17 familial isolated restrictive cardiomyopathy 10.5 TNNT2 TNNI3
18 purpura fulminans 10.5 SERPINC1 F3 F2
19 femoral neuropathy 10.5 PLG F3 F2
20 anterior cranial fossa meningioma 10.5 PLG F3 F2
21 inherited blood coagulation disease 10.5 SERPINC1 F3 F2
22 factor xi deficiency 10.5 SERPINC1 F3 F2
23 carotid artery dissection 10.5 PLG PLAT MTHFR
24 heparin-induced thrombocytopenia 10.5 SERPINC1 F3 F10
25 grange syndrome 10.5 PLAT MTHFR F3
26 posterior myocardial infarction 10.5 SERPINC1 PLAT
27 malignant otitis externa 10.4 F2 CRP
28 plasminogen activator inhibitor-1 deficiency 10.4 SERPINE1 PLAT
29 esophageal varix 10.4 SERPINC1 F2 ALB
30 factor vii deficiency 10.4 F3 F2 F10
31 hypersplenism 10.4 SERPINC1 F2 ALB
32 central serous chorioretinopathy 10.4 SERPINE1 PLAT
33 intracranial embolism 10.4 SERPINC1 PLG PLAT F2
34 hepatic tuberculosis 10.4 F2 ALB
35 splenic disease 10.4 F3 F2 ALB
36 aspirin allergy 10.4 SERPINE1 SERPINC1
37 hantavirus pulmonary syndrome 10.4 F3 F2
38 neonatal stroke 10.4 SERPINE1 MTHFR
39 intestinal impaction 10.4 SERPINC1 PLG F3 F2
40 giant hemangioma 10.4 SERPINC1 PLG F3 F2
41 afibrinogenemia, congenital 10.4 SERPINC1 PLAT F3 F2
42 korean hemorrhagic fever 10.4 SERPINC1 PLG F3 F2
43 dengue hemorrhagic fever 10.4 F3 F2 ALB
44 paracetamol poisoning 10.4 F5 F2
45 fibrinolytic defect 10.3 SERPINE1 SERPINC1 PLAT
46 tuberculous empyema 10.3 SERPINE1 PLG
47 kwashiorkor 10.3 F2 ALB
48 phenytoin toxicity 10.3 VKORC1 ALB
49 argentine hemorrhagic fever 10.3 SERPINE1 SERPINC1 PLAT
50 retinal vascular disease 10.3 PLG MTHFR ALB

Graphical network of the top 20 diseases related to Pulmonary Artery Disease:



Diseases related to Pulmonary Artery Disease

Symptoms & Phenotypes for Pulmonary Artery Disease

MGI Mouse Phenotypes related to Pulmonary Artery Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.21 CRP F10 F2 F3 F5 FABP3
2 homeostasis/metabolism MP:0005376 10.2 ALB CRP F10 F2 F3 F5
3 mortality/aging MP:0010768 10.03 ALB F10 F2 F3 F5 FABP3
4 liver/biliary system MP:0005370 9.86 ALB F5 FABP3 MTHFR PLG PPARGC1B
5 muscle MP:0005369 9.5 ALB F3 FABP3 PLAT PPARGC1B TNNI3
6 respiratory system MP:0005388 9.17 F2 F3 PLAT PLG PPARGC1B SERPINE1

Drugs & Therapeutics for Pulmonary Artery Disease

Search Clinical Trials , NIH Clinical Center for Pulmonary Artery Disease

Genetic Tests for Pulmonary Artery Disease

Genetic tests related to Pulmonary Artery Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Pulmonary Artery 29

Anatomical Context for Pulmonary Artery Disease

MalaCards organs/tissues related to Pulmonary Artery Disease:

41
Lung, Heart, Endothelial, Smooth Muscle

Publications for Pulmonary Artery Disease

Articles related to Pulmonary Artery Disease:

(show all 34)
# Title Authors PMID Year
1
Acute Pulmonary Embolism: Imaging Techniques, Findings, Endovascular Treatment and Differential Diagnoses. 38
31137046 2019
2
State-of-the-art pulmonary arterial imaging - Part 2. 38
29806799 2018
3
Isolated left-sided partial anomalous pulmonary venous connection in a child. 38
28902647 2017
4
Imaging in vascular diseases of the lung. 38
27270181 2016
5
Predictive value of NT-proBNP combined with exercise capacity variables in pulmonary artery disease: Insights from a Spanish cohort. 38
25804462 2015
6
C-reactive protein induces pulmonary artery smooth cell proliferation via modulation of ERK1/2, Akt and NF-kappaB pathways. 38
25185422 2014
7
Comorbidities of COPD. 38
24293462 2013
8
Surgical outcome of two difficult cases with predominant proximal pulmonary artery lesions of chronic thromboembolic pulmonary hypertension. 38
23555449 2011
9
Orally active prostacyclin analogue for cardiovascular disease. 38
20357744 2010
10
Intimal sarcoma of the pulmonary artery: a report of two cases. 38
20058517 2009
11
HIV Nef protein causes endothelial dysfunction in porcine pulmonary arteries and human pulmonary artery endothelial cells. 38
19540523 2009
12
Pulmonary hypertension in patients with end-stage renal disease undergoing renal transplantation. 38
19765426 2009
13
Antithrombotic therapy for peripheral artery occlusive disease: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). 38
18574279 2008
14
Highly variable cutis laxa resulting from a dominant splicing mutation of the elastin gene. 38
18348261 2008
15
Japanese single-center experience of surgery for chronic thromboembolic pulmonary hypertension. 38
16863777 2006
16
Diagnosis of perfusion abnormality of the pulmonary artery in Takayasu's arteritis using contrast-enhanced MR perfusion imaging. 38
16416104 2006
17
PDGF and IL-1beta upregulate cofilin and LIMK2 in canine cultured pulmonary artery smooth muscle cells. 38
15467300 2004
18
Reconstruction of bilateral branch pulmonary artery stenosis caused by Takayasu's aortitis. 38
15277740 2004
19
[Magnetic resonance imaging and lung perfusion scintigraphy in tetralogy of Fallot following surgery]. 38
14757020 2004
20
[A case of an advanced aged Eisenmenger's syndrome]. 38
11201176 2000
21
Inhaled nitric oxide. 38
10709861 2000
22
[Pulmonary thrombendarteriectomy]. 38
19479392 1997
23
Cardiovascular applications of magnetic resonance flow and velocity measurements. 38
8851410 1996
24
Morbidity risk assessment in the surgically anemic patient. 38
8546245 1995
25
Pulmonary MR angiography at 1.0 T: early results with k-space segmented and post-contrast TurboFLASH two-dimensional time-of-flight sequences. 38
7556263 1995
26
Pulmonary artery disease in Takayasu's arteritis: angiographic findings. 38
1352939 1992
27
Treatment of hypertension: the place of angiotensin-converting enzyme inhibitors in the nineties. 38
1283428 1992
28
[Severe pulmonary artery involvement of Takayasu arteritis. 3 cases and review of the literature]. 38
1680319 1991
29
Right-to-left shunting through a patent foramen ovale caused by pulmonary hypertension associated with rheumatoid arthritis and Sjögren's syndrome: a case report. 38
2278405 1990
30
Incidence of pulmonary embolism in elderly patients newly admitted to an acute geriatric unit: a prospective study. 38
2311328 1990
31
[Surgery of congenital acyanotic cardiac malformations (author's transl)]. 38
721031 1978
32
Pulmonary artery involvement in Takayasu's arteritis. 38
14812 1975
33
Vaso-occlusive pulmonary artery disease in the cat. A preliminary report. 38
4531189 1972
34
[An abnormality of the pulmonary artery]. 38
13259605 1955

Variations for Pulmonary Artery Disease

Expression for Pulmonary Artery Disease

Search GEO for disease gene expression data for Pulmonary Artery Disease.

Pathways for Pulmonary Artery Disease

Pathways related to Pulmonary Artery Disease according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.99 SERPINE1 SERPINC1 PLG PLAT F5 F3
2
Show member pathways
12.56 SERPINC1 F5 F3 F2 F10
3
Show member pathways
12.03 SERPINE1 PLG PLAT MTHFR F2 CRP
4 11.79 TNNT2 TNNI3 ALB
5
Show member pathways
11.76 SERPINE1 SERPINC1 PLG PLAT F5 F3
6
Show member pathways
11.75 PLG PLAT F2
7 11.72 SERPINE1 PLG F3
8 11.37 SERPINE1 PLG PLAT
9 11.37 SERPINE1 SERPINC1 PLG PLAT F5 F3
10 10.83 PLG F2
11 10.72 VKORC1 F2 F10
12 10.61 SERPINE1 PLG PLAT

GO Terms for Pulmonary Artery Disease

Cellular components related to Pulmonary Artery Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.72 SERPINC1 F5 F2 F10 ALB
2 blood microparticle GO:0072562 9.71 SERPINC1 PLG F2 ALB
3 extracellular region GO:0005576 9.7 SERPINE1 SERPINC1 PLG PLAT NPPB F5
4 collagen-containing extracellular matrix GO:0062023 9.65 SERPINE1 SERPINC1 PLG PLAT F3
5 troponin complex GO:0005861 9.48 TNNT2 TNNI3
6 cardiac myofibril GO:0097512 9.46 TNNT2 TNNI3
7 platelet alpha granule lumen GO:0031093 9.46 SERPINE1 PLG F5 ALB
8 intrinsic component of external side of plasma membrane GO:0031233 9.43 F3 F10
9 extracellular space GO:0005615 9.4 SERPINE1 SERPINC1 PLG PLAT NPPB FABP3
10 cardiac Troponin complex GO:1990584 9.37 TNNT2 TNNI3

Biological processes related to Pulmonary Artery Disease according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.77 SERPINC1 PLG F5 F2 ALB
2 platelet degranulation GO:0002576 9.71 SERPINE1 PLG F5 ALB
3 regulation of blood coagulation GO:0030193 9.5 VKORC1 SERPINC1 F2
4 regulation of muscle contraction GO:0006937 9.49 TNNT2 TNNI3
5 positive regulation of blood coagulation GO:0030194 9.48 SERPINE1 F2
6 negative regulation of ATPase activity GO:0032780 9.46 TNNT2 TNNI3
7 fibrinolysis GO:0042730 9.46 SERPINE1 PLG PLAT F2
8 blood coagulation, extrinsic pathway GO:0007598 9.43 F3 F10
9 negative regulation of fibrinolysis GO:0051918 9.43 SERPINE1 PLG F2
10 hemostasis GO:0007599 9.43 SERPINC1 PLG F5 F3 F2 F10
11 blood coagulation GO:0007596 9.23 VKORC1 SERPINC1 PLG PLAT F5 F3

Molecular functions related to Pulmonary Artery Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.65 SERPINE1 PLG PLAT NPPB F2
2 protease binding GO:0002020 9.5 SERPINE1 SERPINC1 F3
3 serine-type peptidase activity GO:0008236 9.46 PLG PLAT F2 F10
4 serine-type endopeptidase activity GO:0004252 9.02 PLG PLAT F3 F2 F10
5 troponin C binding GO:0030172 8.96 TNNT2 TNNI3

Sources for Pulmonary Artery Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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