MCID: PLM007
MIFTS: 31

Pulmonary Aspergilloma

Categories: Infectious diseases, Bone diseases, Cardiovascular diseases, Respiratory diseases, Nephrological diseases, Eye diseases, Gastrointestinal diseases, Neuronal diseases

Aliases & Classifications for Pulmonary Aspergilloma

MalaCards integrated aliases for Pulmonary Aspergilloma:

Name: Pulmonary Aspergilloma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050153

Summaries for Pulmonary Aspergilloma

Disease Ontology : 12 An aspergillosis that presents as a clump of tangled mass of Aspergillus fungus fibres, blood clots, and white blood cells, which exists in the cavities of the lungs that develop in an area of previous lung disease or lung scarring.

MalaCards based summary : Pulmonary Aspergilloma is related to lung abscess and suppurative lymphadenitis. An important gene associated with Pulmonary Aspergilloma is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways/superpathways is Development_Leptin signaling via JAK/STAT and MAPK cascades. The drugs Itraconazole and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and eye.

Related Diseases for Pulmonary Aspergilloma

Diseases related to Pulmonary Aspergilloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Related Disease Score Top Affiliating Genes
1 lung abscess 30.5 CRP FLNC
2 suppurative lymphadenitis 10.8 DOCK8 P3H2
3 lymphangiosarcoma 10.6 SMUG1 VEGFA
4 bronchopneumonia 10.6 MPO P3H2
5 spinal disease 10.6 CRP VEGFA
6 leukostasis 10.6 MPO VEGFA
7 cardiac rupture 10.6 CRP FLNC
8 benign struma ovarii 10.5 SMUG1 TG
9 pyuria 10.5 CRP NUMA1
10 pleural empyema 10.5 CRP P3H2
11 ovarian squamous cell carcinoma 10.5 CRP SMUG1
12 hydrops, lactic acidosis, and sideroblastic anemia 10.5 MPO VEGFA
13 pyelitis 10.5 CRP P3H2
14 cartilage disease 10.5 CRP SMUG1
15 mononeuritis multiplex 10.4 CRP MPO
16 cellulitis 10.4 CRP P3H2
17 mediastinitis 10.4 CRP MPO
18 central nervous system vasculitis 10.4 CRP SMUG1
19 pericardium cancer 10.4 MPO SMUG1
20 suppurative thyroiditis 10.4 CRP TG
21 rapidly progressive glomerulonephritis 10.4 CRP MPO
22 tuberculous peritonitis 10.4 CRP SMUG1
23 hypersensitivity vasculitis 10.4 CRP MPO
24 lemierre's syndrome 10.4 CRP SMUG1
25 peliosis hepatis 10.4 HADHA SMUG1 VEGFA
26 hypersensitivity reaction type iii disease 10.4 CRP MPO
27 subacute thyroiditis 10.3 CRP TG
28 intermittent explosive disorder 10.3 CRP SMUG1
29 endocardium disease 10.3 CRP SMUG1
30 pericardial mesothelioma 10.3 MPO SMUG1
31 polyarteritis nodosa 10.3 CRP MPO
32 arteritic anterior ischemic optic neuropathy 10.2 CRP MPO
33 lipid pneumonia 10.2 CRP FLNC SMUG1
34 pleural disease 10.2 CRP MPO
35 aspergillosis 10.2
36 respiratory system disease 10.2 CRP FLNC MPO
37 proctitis 10.2 CRP MPO
38 xanthogranulomatous pyelonephritis 10.1 CRP NUMA1 SMUG1
39 multiple cranial nerve palsy 10.1 CRP MPO
40 myeloma, multiple 10.1 CRP SMUG1 VEGFA
41 skeletal tuberculosis 10.1 CRP SMUG1
42 aortitis 10.1 CRP MPO SMUG1
43 lung cancer 10.0
44 actinomycosis 10.0
45 pelvic inflammatory disease 10.0 CRP MPO
46 spondyloarthropathy 1 9.9
47 cystic fibrosis 9.9
48 anorexia nervosa 9.9
49 allergic bronchopulmonary aspergillosis 9.9
50 thyroid cancer 9.9

Graphical network of the top 20 diseases related to Pulmonary Aspergilloma:



Diseases related to Pulmonary Aspergilloma

Symptoms & Phenotypes for Pulmonary Aspergilloma

Drugs & Therapeutics for Pulmonary Aspergilloma

Drugs for Pulmonary Aspergilloma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Itraconazole Approved, Investigational Phase 3,Phase 2 84625-61-6 55283
2
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2 22916-47-8 4189
3 Antifungal Agents Phase 3,Phase 2
4 Anti-Infective Agents Phase 3,Phase 2
5 Cytochrome P-450 CYP3A Inhibitors Phase 3,Phase 2
6 Cytochrome P-450 Enzyme Inhibitors Phase 3,Phase 2
7 Hormone Antagonists Phase 3,Phase 2
8 Hormones Phase 3,Phase 2
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
10
Hydroxyitraconazole Phase 3,Phase 2
11 Pharmaceutical Solutions Phase 3,Phase 2
12 Steroid Synthesis Inhibitors Phase 3,Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Pharmacokinetic Study of JK1211(Itraconazole [Itrizole]) Oral Solution in Participants With Deep Mycosis and Those With Febrile Neutropenia Suspected of Fungal Infection Completed NCT00784368 Phase 3 ITCZ Oral Solution;ITCZ-IV
2 A Multicenter, Prospective, Randomized, Double-Blind Clinical Trial Comparing Itraconazole Oral Solution in Cyclodextrin to Placebo in the Treatment of Aspergilloma Completed NCT00005668 Phase 2 Itraconazole oral solution
3 Outcome After Treatment of Pulmonary Aspergilloma Unknown status NCT01958710

Search NIH Clinical Center for Pulmonary Aspergilloma

Genetic Tests for Pulmonary Aspergilloma

Anatomical Context for Pulmonary Aspergilloma

MalaCards organs/tissues related to Pulmonary Aspergilloma:

41
Lung, Bone, Eye, Thyroid, Endothelial, B Cells, Heart

Publications for Pulmonary Aspergilloma

Articles related to Pulmonary Aspergilloma:

(show top 50) (show all 189)
# Title Authors Year
1
Pulmonary Aspergilloma with Oxalosis. ( 29709953 )
2018
2
Feasibility of surgery for pulmonary aspergilloma: analysis of the operative modes. ( 29542058 )
2018
3
Pulmonary aspergilloma mimicking synchronous lung cancer on PET/CT in a patient with head and neck cancer. ( 29361322 )
2018
4
Complex Pulmonary Aspergilloma: Surgical Challenges in a Third World Setting. ( 29594190 )
2018
5
Pulmonary Actinomycosis Mimicking Pulmonary Aspergilloma and a Brief Review of the Literature. ( 28202870 )
2017
6
Intervention treatment on massive hemoptysis of pulmonary aspergilloma. ( 28565835 )
2017
7
Video-assisted thoracoscopic surgery for pulmonary aspergilloma. ( 28671161 )
2017
8
Sublobar Resection for Pulmonary Aspergilloma: A Safe Alternative toA Lobectomy. ( 28366461 )
2017
9
Coexistence of Pulmonary Aspergilloma and Allergic Bronchopulmonary Aspergillosis. ( 28768986 )
2017
10
Surgical treatment for pulmonary aspergilloma - early and long-term results. ( 28747940 )
2017
11
Pulmonary Hypertension and Pulmonary Aspergilloma-Coexistence of Two Rare Sequelae of Pulmonary Embolism. ( 27408402 )
2016
12
Cystic Bronchiectasis Imitating Pulmonary Aspergilloma. ( 27569246 )
2016
13
Pulmonary aspergilloma: An evasive disease. ( 27242239 )
2016
14
The Association of Mounier-Kuhn Syndrome and Pulmonary Aspergillomas: A Case Report. ( 27761295 )
2016
15
A Series of Transbronchial Removal of Intracavitary Pulmonary Aspergilloma. ( 27765172 )
2016
16
Intrabronchial Voriconazole is a Safe and Effective Measure for Hemoptysis Control in Pulmonary Aspergilloma. ( 27623423 )
2016
17
Genome sequence comparison of Aspergillus fumigatus strains isolated from patients with pulmonary aspergilloma and chronic necrotizing pulmonary aspergillosis. ( 25851262 )
2015
18
Lung resection in pulmonary aspergilloma: experience of a Moroccan center. ( 26475478 )
2015
19
A comparative study of itraconazole in various dose schedules in the treatment of pulmonary aspergilloma in treated patients of pulmonary tuberculosis. ( 26180383 )
2015
20
Intracavitary pulmonary aspergilloma: endoscopic aspects. ( 26176528 )
2015
21
Interstitial Lung Disease in Systemic Scleroderma, Complicated with Bilateral Pulmonary Aspergilloma: An Unusual Association. ( 26816937 )
2015
22
Surgical management of pulmonary aspergilloma: clinical experience with 77 cases. ( 26084137 )
2015
23
Results of surgical treatment for pulmonary aspergilloma. ( 25786611 )
2015
24
A rare case of calcified pulmonary aspergilloma. ( 24669092 )
2014
25
Video-assisted thoracic surgery for pulmonary aspergilloma: a safe and effective procedure. ( 24094518 )
2014
26
Complex pulmonary aspergilloma treated by cavernostomy. ( 25742406 )
2014
27
Direct transbronchial administration of liposomal amphotericin B into a pulmonary aspergilloma. ( 26029520 )
2014
28
Pulmonary aspergilloma: an unexpected complication of radiofrequency ablation in the management of targeted therapy for a patient with metastatic renal cell carcinoma. ( 24524970 )
2014
29
Simplified cavernostomy using wound protector for complex pulmonary aspergilloma. ( 24996732 )
2014
30
Pulmonary aspergilloma: A rare differential diagnosis to lung cancer after positive FDG PET scan. ( 26029524 )
2014
31
Is video-assisted thoracic surgery a versatile treatment for both simple and complex pulmonary aspergilloma? ( 24605221 )
2014
32
Clinical course and prognostic factors of pulmonary aspergilloma. ( 24995570 )
2014
33
A case of pulmonary aspergilloma without actinomycosis. ( 23618798 )
2013
34
Always expect the unexpected: lung abscess due to pseudomonas aeruginosa mimicking pulmonary aspergilloma in acute B-cell leukemia. ( 24166086 )
2013
35
Pulmonary aspergilloma: a treatment challenge in sub-Saharan Africa. ( 24205413 )
2013
36
A modern series of percutaneous intracavitary instillation of amphotericin B for the treatment of severe hemoptysis from pulmonary aspergilloma. ( 23117277 )
2013
37
First case report of single port video-assisted thoracoscopic middle lobectomy for the treatment of pulmonary aspergilloma in a pediatric patient. ( 25755940 )
2013
38
Endovascular aortic repair for a pulmonary aspergilloma fistulized into the descending aorta: selective intubation with a single-lumen tube under fluoroscopic guidance. ( 23242989 )
2013
39
Treatment of pulmonary aspergilloma in Srinagarind Hospital. ( 24386754 )
2013
40
A Case of Pulmonary Aspergilloma Treated with Radiofrequency Ablation. ( 24196265 )
2013
41
Bronchoscopic removal of a large intracavitary pulmonary aspergilloma. ( 23276848 )
2013
42
Pulmonary Aspergilloma in a Cavity Formed After Percutaneous Radiofrequency Ablation. ( 23636252 )
2013
43
A case of pulmonary aspergilloma without actinomycosis. ( 23538562 )
2013
44
Surgical treatment for pulmonary aspergilloma: a 35-year experience in the Chinese population. ( 22499801 )
2012
45
Pulmonary aspergilloma in patient with anorexia nervosa: case report. ( 22374072 )
2012
46
The clinical efficacy and safety of micafungin-itraconazole combination therapy in patients with pulmonary aspergilloma. ( 22350405 )
2012
47
Pulmonary aspergilloma treated by limited thoracoplasty with simultaneous cavernostomy and muscle transposition flap. ( 22446949 )
2012
48
Pulmonary aspergilloma: a potential cause of false positive fluorodeoxyglucose positron emission tomography scan. ( 22627956 )
2012
49
Pulmonary aspergilloma. ( 23409527 )
2012
50
Pulmonary aspergilloma: clinical aspects and surgical treatment outcome. ( 22789598 )
2012

Variations for Pulmonary Aspergilloma

Expression for Pulmonary Aspergilloma

Search GEO for disease gene expression data for Pulmonary Aspergilloma.

Pathways for Pulmonary Aspergilloma

Pathways related to Pulmonary Aspergilloma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.1 CRP VEGFA

GO Terms for Pulmonary Aspergilloma

Sources for Pulmonary Aspergilloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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