MCID: PLM007
MIFTS: 29

Pulmonary Aspergilloma

Categories: Blood diseases, Infectious diseases, Respiratory diseases

Aliases & Classifications for Pulmonary Aspergilloma

MalaCards integrated aliases for Pulmonary Aspergilloma:

Name: Pulmonary Aspergilloma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050153

Summaries for Pulmonary Aspergilloma

Disease Ontology : 12 An aspergillosis that presents as a clump of tangled mass of Aspergillus fungus fibres, blood clots, and white blood cells, which exists in the cavities of the lungs that develop in an area of previous lung disease or lung scarring.

MalaCards based summary : Pulmonary Aspergilloma is related to pericardial effusion and mucormycosis. An important gene associated with Pulmonary Aspergilloma is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways/superpathways are Creation of C4 and C2 activators and Development_Leptin signaling via JAK/STAT and MAPK cascades. The drugs Guaifenesin and Clotrimazole have been mentioned in the context of this disorder. Affiliated tissues include lung, spinal cord and thyroid.

Related Diseases for Pulmonary Aspergilloma

Diseases related to Pulmonary Aspergilloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 139)
# Related Disease Score Top Affiliating Genes
1 pericardial effusion 30.0 VEGFA CRP
2 mucormycosis 29.9 CYP51A1 CRP
3 fungal infectious disease 29.8 CYP51A1 CRP
4 aspergillosis 10.7
5 pleural empyema 10.5
6 respiratory failure 10.4
7 lung disease 10.4
8 bronchiectasis 10.4
9 pulmonary tuberculosis 10.4
10 mycetoma 10.4
11 lung abscess 10.3
12 pneumothorax 10.3
13 virus-associated trichodysplasia spinulosa 10.3
14 invasive aspergillosis 10.3
15 sarcoidosis 1 10.2
16 allergic bronchopulmonary aspergillosis 10.2
17 mannose-binding lectin deficiency 10.2 FCN3 FCN1
18 posterior scleritis 10.2 VEGFA CRP
19 plantar fasciitis 10.2 VEGFA CRP
20 soft tissue sarcoma 10.2 VEGFA CRP
21 branch retinal artery occlusion 10.2 VEGFA CRP
22 retinal artery occlusion 10.2 VEGFA CRP
23 hypopyon 10.2 VEGFA CRP
24 buerger disease 10.2 VEGFA CRP
25 hypertensive retinopathy 10.2 VEGFA CRP
26 bartonellosis 10.2 VEGFA CRP
27 central retinal artery occlusion 10.2 VEGFA CRP
28 scleral disease 10.2 VEGFA CRP
29 iritis 10.2 VEGFA CRP
30 background diabetic retinopathy 10.2 VEGFA CRP
31 chorioretinitis 10.2 VEGFA CRP
32 iridocyclitis 10.2 VEGFA CRP
33 allergic disease 10.2
34 pulmonary fibrosis 10.2
35 actinomycosis 10.2
36 hantavirus hemorrhagic fever with renal syndrome 10.2 VEGFA CRP
37 tendinitis 10.2 VEGFA CRP
38 blood group, globoside system 10.2 VEGFA CRP
39 decubitus ulcer 10.2 VEGFA CRP
40 central nervous system vasculitis 10.2 VEGFA CRP
41 papilledema 10.2 VEGFA CRP
42 progressive relapsing multiple sclerosis 10.2 FCN3 FCN1
43 ischemic colitis 10.2 VEGFA CRP
44 endophthalmitis 10.2 VEGFA CRP
45 intestinal perforation 10.2 VEGFA CRP
46 fallopian tube disease 10.2 VEGFA CRP
47 retinal vascular occlusion 10.2 VEGFA CRP
48 chronic ulcer of skin 10.2 VEGFA CRP
49 intussusception 10.1 VEGFA CRP
50 multicentric castleman disease 10.1 VEGFA CRP

Graphical network of the top 20 diseases related to Pulmonary Aspergilloma:



Diseases related to Pulmonary Aspergilloma

Symptoms & Phenotypes for Pulmonary Aspergilloma

Drugs & Therapeutics for Pulmonary Aspergilloma

Drugs for Pulmonary Aspergilloma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Guaifenesin Approved, Investigational, Vet_approved Phase 2, Phase 3 93-14-1 3516
2
Clotrimazole Approved, Vet_approved Phase 2, Phase 3 23593-75-1 2812
3
Phenylpropanolamine Approved, Vet_approved, Withdrawn Phase 2, Phase 3 14838-15-4 26934
4
Voriconazole Approved Phase 2, Phase 3 137234-62-9 71616
5
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3 22916-47-8 4189
6 Cytochrome P-450 CYP3A Inhibitors Phase 2, Phase 3
7 Hemostatics Phase 2, Phase 3
8 Cytochrome P-450 Enzyme Inhibitors Phase 2, Phase 3
9 Hormone Antagonists Phase 2, Phase 3
10 Chlorpheniramine, phenylpropanolamine drug combination Phase 2, Phase 3
11 Hormones Phase 2, Phase 3
12 Antitussive Agents Phase 2, Phase 3
13 Anti-Infective Agents Phase 2, Phase 3
14 Antifungal Agents Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy of Intrabronchial Voriconazole Instillation for Inoperable Pulmonary Aspergilloma- a Randomized Controlled Trial Unknown status NCT03799809 Phase 2, Phase 3 Intrabronchial Voriconazole instillation

Search NIH Clinical Center for Pulmonary Aspergilloma

Genetic Tests for Pulmonary Aspergilloma

Anatomical Context for Pulmonary Aspergilloma

MalaCards organs/tissues related to Pulmonary Aspergilloma:

40
Lung, Spinal Cord, Thyroid, Myeloid, Endothelial

Publications for Pulmonary Aspergilloma

Articles related to Pulmonary Aspergilloma:

(show top 50) (show all 474)
# Title Authors PMID Year
1
Rare Infant Case of Pulmonary Aspergilloma Highlighting Common Challenges With Voriconazole Dosing. 61
33565811 2021
2
Pulmonary aspergilloma on transthoracic ultrasound. 61
33751448 2021
3
Plombage for Hemoptysis Control in Pulmonary Aspergilloma: Safety and Effectiveness of Forgettable Surgery in High-Risk Patients. 61
33408306 2021
4
Pulmonary Aspergilloma Removal Using a Large-Bore Suction Catheter System. 61
33162310 2020
5
Clinical features and outcome of patients with chronic pulmonary aspergillosis in China: A retrospective, observational study. 61
32950379 2020
6
Successful treatment with nivolumab in a patient with lung adenocarcinoma complicated by pulmonary aspergilloma. 61
32941695 2020
7
Pulmonary aspergilloma. 61
32077956 2020
8
Surgical treatment of pulmonary aspergilloma in pediatric patients: report of 3 cases. 61
33016660 2020
9
Cavernostomy in the Treatment of Pulmonary Aspergilloma in a High Surgical Risk Patient. 61
32493644 2020
10
A Case of Vanishing Pulmonary Aspergilloma. 61
31176501 2020
11
Non-surgical treatment options for pulmonary aspergilloma. 61
32217289 2020
12
[Clinical Investigation of Surgical Cases for Pulmonary Aspergillosis]. 61
32393711 2020
13
Pulmonary aspergilloma: from classification to management. 61
31799858 2020
14
Hemoptysis from complex pulmonary aspergilloma treated by cavernostomy and thoracoplasty. 61
31805919 2019
15
Bronchial arterial embolization using a gelatin sponge for hemoptysis from pulmonary aspergilloma: comparison with other pulmonary diseases. 61
31129737 2019
16
Uniportal Video-assisted Thoracoscopic Surgery for Pulmonary Aspergilloma: A Report of 5 Cases. 61
31083021 2019
17
Pulmonary aspergilloma: surgical outcome of 79 patients in a Moroccan center. 61
31166694 2019
18
Evaluation of Aspergillus-Specific Lateral-Flow Device Test Using Serum and Bronchoalveolar Lavage Fluid for Diagnosis of Chronic Pulmonary Aspergillosis. 61
30842231 2019
19
Pulmonary aspergilloma with subcutaneous fistula resulting in massive hemoptysis & subcutaneous emphysema. 61
31193387 2019
20
Is adjuvant antifungal therapy after video-assisted thoracic surgery for pulmonary aspergilloma necessary? 61
30622777 2018
21
Pulmonary Aspergilloma with Oxalosis. 61
29709953 2018
22
Case report: retroperitoneal aspergilloma in a patient with rheumatoid arthritis presenting as malignant tumor. 61
30064423 2018
23
Post-tuberculosis Aspergilloma in Undiagnosed Tetralogy of Fallot. 61
30087816 2018
24
[Assessment of Surgical Treatment for Chronic Pulmonary Aspergillosis]. 61
29755081 2018
25
Feasibility of surgery for pulmonary aspergilloma: analysis of the operative modes. 61
29542058 2018
26
Pulmonary aspergilloma mimicking synchronous lung cancer on PET/CT in a patient with head and neck cancer. 61
29361322 2018
27
[Post-traumatic pulmonary aspergilloma]. 61
29602478 2018
28
Complex Pulmonary Aspergilloma: Surgical Challenges in a Third World Setting. 61
29594190 2018
29
[Investigation of Virulence Factors by "Omics" Approaches]. 61
29848910 2018
30
Video-assisted thoracoscopic surgery for pulmonary aspergilloma. 61
28671161 2017
31
Sublobar Resection for Pulmonary Aspergilloma: A Safe Alternative to Lobectomy. 61
28366461 2017
32
Surgical treatment for pulmonary aspergilloma - early and long-term results. 61
28747940 2017
33
Intervention treatment on massive hemoptysis of pulmonary aspergilloma. 61
28565835 2017
34
A Series of Transbronchial Removal of Intracavitary Pulmonary Aspergilloma. 61
27765172 2017
35
Pulmonary Actinomycosis Mimicking Pulmonary Aspergilloma and a Brief Review of the Literature. 61
28202870 2017
36
[The tree that hides the forest: aspergillosis associated with bronchial carcinoma (about two cases)]. 61
29721133 2017
37
Development of Aspergillosis in a cohort of non-neutropenic, non-transplant patients colonised by Aspergillus spp. 61
28056830 2017
38
Coexistence of Pulmonary Aspergilloma and Allergic Bronchopulmonary Aspergillosis. 61
28768986 2017
39
Intrabronchial Voriconazole is a Safe and Effective Measure for Hemoptysis Control in Pulmonary Aspergilloma. 61
27623423 2017
40
Cystic Bronchiectasis Imitating Pulmonary Aspergilloma. 61
27569246 2016
41
Pulmonary aspergilloma: An evasive disease. 61
27242239 2016
42
Pulmonary Hypertension and Pulmonary Aspergilloma-Coexistence of Two Rare Sequelae of Pulmonary Embolism. 61
27408402 2016
43
A 10-year study reveals clinical and laboratory evidence for the 'semi-invasive' properties of chronic pulmonary aspergillosis. 61
27094904 2016
44
[Preoperative Arterial Embolization with N-butyl-2 Cyanoacrylate for Chronic Cavitary Pulmonary Aspergillosis with Trauma Induced Type Ⅰ Diabetes Mellitus]. 61
27075282 2016
45
Surgical treatment of pulmonary aspergillosis: A single center experience. 61
26933300 2016
46
Robotic assisted thoracoscopic right upper lobectomy for post tuberculosis aspergilloma. 61
29078479 2016
47
Interstitial Lung Disease in Systemic Scleroderma, Complicated with Bilateral Pulmonary Aspergilloma: An Unusual Association. 61
26816937 2015
48
Hemoptysis due to fungus ball after tuberculosis: A series of 21 cases treated with hemostatic radiotherapy. 61
26612361 2015
49
[Pulmonary Aspergilloma: Indications for Surgery and Surgical Techniques]. 61
26351763 2015
50
Lung resection in pulmonary aspergilloma: experience of a Moroccan center. 61
26475478 2015

Variations for Pulmonary Aspergilloma

Expression for Pulmonary Aspergilloma

Search GEO for disease gene expression data for Pulmonary Aspergilloma.

Pathways for Pulmonary Aspergilloma

GO Terms for Pulmonary Aspergilloma

Cellular components related to Pulmonary Aspergilloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 VEGFA TG FCN3 FCN1 CRP

Biological processes related to Pulmonary Aspergilloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of viral entry into host cell GO:0046597 9.16 FCN3 FCN1
2 complement activation, lectin pathway GO:0001867 8.96 FCN3 FCN1
3 recognition of apoptotic cell GO:0043654 8.62 FCN3 FCN1

Sources for Pulmonary Aspergilloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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