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MCID: PLM010
MIFTS: 56

Pulmonary Edema

Categories: Respiratory diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Pulmonary Edema

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MalaCards integrated aliases for Pulmonary Edema:

Name: Pulmonary Edema 12 44 15 73

Classifications:

MalaCards categories:
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:11396
ICD10 33 J81 J81.1
MeSH 44 D011654
NCIt 50 C26868
UMLS 73 C0034063
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Summaries for Pulmonary Edema

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MalaCards based summary : Pulmonary Edema is related to acute respiratory distress syndrome and acute mountain sickness, and has symptoms including edema, hemoptysis and peau d'orange. An important gene associated with Pulmonary Edema is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are Immune response IL-23 signaling pathway and Insulin receptor recycling. The drugs Sevoflurane and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and kidney, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 76 Pulmonary edema is fluid accumulation in the tissue and air spaces of the lungs. It leads to impaired... more...

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Related Diseases for Pulmonary Edema

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Diseases related to Pulmonary Edema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 431)
# Related Disease Score Top Affiliating Genes
1 acute respiratory distress syndrome 33.2 CXCL8 IL1B TNF
2 acute mountain sickness 33.0 ACE EDN1 NOS3 PIK3C2A
3 chronic mountain sickness 32.6 EDN1 NOS3 NPPB
4 adult respiratory distress syndrome 32.5 ACE CXCL8 F2 IL10 TNF
5 diastolic heart failure 30.8 ACE NOS3 NPPB
6 aortic coarctation 30.6 ACE EDN1 NOS3
7 mitral valve disease 30.3 ACE IL10 NOS3
8 anuria 30.3 ACE PIK3C2A REN
9 cardiac tamponade 30.2 F2 NPPB REN
10 myocarditis 30.2 ICAM1 NPPB TNF
11 bronchiolitis obliterans 30.1 CXCL8 IL10 TNF
12 bronchiolitis 30.0 CXCL8 IL10 TNF
13 plasmodium vivax malaria 30.0 ICAM1 IL10 TNF
14 congestive heart failure 29.9 ACE EDN1 NPPB PIK3C2A REN
15 spinal cord infarction 29.7 F2 SERPINC1
16 hepatorenal syndrome 29.7 ACE EDN1 F2 REN
17 ischemia 29.5 ACE EDN1 HMOX1 ICAM1 NOS3
18 pulmonary hypertension 29.4 ACE EDN1 NOS3 NPPB REN SERPINC1
19 subendocardial myocardial infarction 29.4 F2 ICAM1 SERPINC1
20 eclampsia 29.3 EDN1 F2 SERPINC1 TNF
21 disseminated intravascular coagulation 29.3 F2 PIK3C2A SERPINC1
22 hellp syndrome 29.3 EDN1 F2 SERPINC1
23 autosomal dominant polycystic kidney disease 29.2 ACE CFTR EDN1 NOS3 REN
24 mouth disease 29.2 CRP IL10 IL1B TNF
25 cardiogenic shock 29.1 CRP NPPB PIK3C2A
26 apnea, obstructive sleep 29.1 CRP EDN1 REN TNF
27 intracranial hypertension 29.0 F2 IL1B SERPINC1 TNF
28 renovascular hypertension 29.0 ACE EDN1 HMOX1 NOS3 REN
29 respiratory failure 28.8 ACE CRP CXCL8 PIK3C2A TNF
30 meningitis 28.6 CRP CXCL8 IL10 IL1B TNF
31 kidney disease 28.5 ACE CRP EDN1 NPPB REN
32 pneumonia 28.2 CRP CXCL8 IL10 IL1B PIK3C2A TNF
33 pulmonary embolism 28.1 CRP F2 NPPB SERPINC1
34 lung disease 28.1 CFTR CXCL8 EDN1 IL10 IL1B NPPB
35 acute myocardial infarction 27.9 ACE CRP EDN1 NPPB PIK3C2A SERPINC1
36 coronary artery anomaly 27.4 ACE CRP EDN1 ICAM1 NOS3 NPPB
37 pulmonary disease, chronic obstructive 27.3 CFTR CRP CXCL8 HMOX1 NPPB TNF
38 arteriosclerosis 27.3 ACE CRP EDN1 HMOX1 ICAM1 IL10
39 asthma 27.2 CFTR CXCL8 EDN1 F2 ICAM1 IL10
40 diabetes mellitus 27.2 ACE CRP EDN1 IL1B NOS3 PIK3C2A
41 sleep apnea 27.0 ACE CRP CXCL8 EDN1 ICAM1 NOS3
42 malaria 26.6 CRP CXCL8 EDN1 HMOX1 ICAM1 IL10
43 pre-eclampsia 26.2 EDN1 F2 HMOX1 ICAM1 IL10 NOS3
44 arteries, anomalies of 24.9 ACE CRP EDN1 F2 ICAM1 IL1B
45 heart disease 24.8 ACE CRP EDN1 F2 IL1B NOS3
46 vascular disease 24.7 ACE CRP EDN1 F2 HMOX1 ICAM1
47 myocardial infarction 24.3 ACE CRP EDN1 F2 ICAM1 IL10
48 pulmonary edema of mountaineers 12.3
49 toxic pneumonitis 11.2
50 hantavirus pulmonary syndrome 11.2

Graphical network of the top 20 diseases related to Pulmonary Edema:



Diseases related to Pulmonary Edema
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Symptoms & Phenotypes for Pulmonary Edema

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UMLS symptoms related to Pulmonary Edema:


edema, hemoptysis, peau d'orange

GenomeRNAi Phenotypes related to Pulmonary Edema according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.92 ACE REN CFTR TNF CXCL8 F2
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.92 IL1B ACE REN CFTR TNF CXCL8

MGI Mouse Phenotypes related to Pulmonary Edema:

46 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.39 NOS3 IL10 IL1B ICAM1 CRP EDN1
2 homeostasis/metabolism MP:0005376 10.38 NOS3 IL10 HMOX1 IL1B ICAM1 CRP
3 growth/size/body region MP:0005378 10.32 ICAM1 NOS3 IL10 HMOX1 IL1B REN
4 behavior/neurological MP:0005386 10.3 NOS3 IL10 HMOX1 ACE REN TRPV4
5 hematopoietic system MP:0005397 10.27 ICAM1 NOS3 IL10 HMOX1 IL1B REN
6 immune system MP:0005387 10.27 NOS3 IL10 HMOX1 IL1B ICAM1 ACE
7 mortality/aging MP:0010768 10.25 NOS3 IL10 HMOX1 IL1B ICAM1 REN
8 endocrine/exocrine gland MP:0005379 10.18 ICAM1 IL10 HMOX1 TNF ACE EDN1
9 digestive/alimentary MP:0005381 10.14 ICAM1 NOS3 IL10 EDN1 AQP5 F2
10 nervous system MP:0003631 10.06 IL1B ICAM1 TRPV4 IL10 TNF REN
11 muscle MP:0005369 10.02 ICAM1 NOS3 IL10 HMOX1 REN TRPV4
12 liver/biliary system MP:0005370 9.98 IL10 HMOX1 CFTR TNF ACE NOS3
13 renal/urinary system MP:0005367 9.86 NOS3 HMOX1 ACE REN TRPV4 EDN1
14 reproductive system MP:0005389 9.81 IL10 HMOX1 TNF ACE REN NOS3
15 respiratory system MP:0005388 9.56 NOS3 IL10 HMOX1 TRPV4 AQP5 F2
16 vision/eye MP:0005391 9.23 TRPV4 ICAM1 IL10 TNF NOS3 SERPINC1
Sources

Drugs & Therapeutics for Pulmonary Edema

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Drugs for Pulmonary Edema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 307)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
2
Bupivacaine Approved, Investigational Phase 4,Phase 1 2180-92-9, 38396-39-3 2474
3
Dobutamine Approved Phase 4,Phase 3,Not Applicable 34368-04-2 36811
4
Menthol Approved Phase 4,Not Applicable 2216-51-5 16666
5
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
6
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
7
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
8
Remifentanil Approved Phase 4,Phase 2 132875-61-7 60815
9
Acetazolamide Approved, Vet_approved Phase 4,Not Applicable 59-66-5 1986
10
Heparin Approved, Investigational Phase 4,Phase 3 9005-49-6 772 46507594
11
Methylprednisolone Approved, Vet_approved Phase 4,Not Applicable 83-43-2 6741
12
Prednisolone Approved, Vet_approved Phase 4,Not Applicable 50-24-8 5755
13
Diltiazem Approved, Investigational Phase 4 42399-41-7 39186
14
Metoprolol Approved, Investigational Phase 4,Not Applicable 37350-58-6, 51384-51-1 4171
15
Propranolol Approved, Investigational Phase 4 525-66-6 4946
16
Verapamil Approved Phase 4 52-53-9 2520
17
Morphine Approved, Investigational Phase 4 57-27-2 5288826
18
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 2 113775-47-6 68602 5311068
19
Benzocaine Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 1994-09-7, 94-09-7 2337
20
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 7487-88-9 24083
21
Milrinone Approved Phase 4 78415-72-2 4197
22
Labetalol Approved Phase 4 36894-69-6 3869
23
Nifedipine Approved Phase 4 21829-25-4 4485
24
Cefuroxime Approved Phase 4 55268-75-2 5361202 5479529
25
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
26
Metronidazole Approved Phase 4 443-48-1 4173
27
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
28
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
29
Zinc Approved, Investigational Phase 4 7440-66-6 23994
30
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Early Phase 1,Not Applicable 77-92-9 311
31
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
32 tannic acid Approved, Nutraceutical Phase 4,Phase 1,Phase 2,Not Applicable
33
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
34
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 6221 5280795
35 Anticholesteremic Agents Phase 4,Not Applicable
36 Antimetabolites Phase 4,Not Applicable
37 Atorvastatin Calcium Phase 4,Phase 3 134523-03-8
38 Calcium, Dietary Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
39 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4,Not Applicable
40 Hypolipidemic Agents Phase 4,Not Applicable
41 Lipid Regulating Agents Phase 4,Not Applicable
42 Anesthetics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
43 Anesthetics, General Phase 4,Phase 2
44 Anesthetics, Inhalation Phase 4,Phase 2
45 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 Platelet Aggregation Inhibitors Phase 4,Phase 2
47 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
48 Vasodilator Agents Phase 4,Phase 1,Phase 2,Not Applicable,Early Phase 1
49 Adrenergic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
50 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 363)
# Name Status NCT ID Phase Drugs
1 Impact of Fluid Resuscitation Therapy on Pulmonary Edema as Measured by Alveolar Fluid Clearance in Patients With Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT01763853 Phase 4 4% albumin
2 Comparison of Nasal CPAP and Nasal SIMV in Transient Tachypnea of Newborn Unknown status NCT01499238 Phase 4
3 Effects of Atorvastatin Treatment on Left Ventricular Diastolic Function in Peritoneal Dialysis Patients Unknown status NCT01503671 Phase 4 Atorvastatin
4 A Comparison of Two Anaesthetic Methods of Protecting Heart Tissue During Cardiac Surgery Unknown status NCT00244283 Phase 4 Sevoflurane
5 Comparative Study of Non-Invasive Mask Ventilation vs Cuirass Ventilation in Patients With Acute Respiratory Failure. Unknown status NCT00331656 Phase 4
6 Prevention of Contrast Nephropathy During Diagnostic Coronary Angiogram or PCI With Hydratation Based on LEVDP Unknown status NCT00584350 Phase 4
7 Hemocontrol's Effectiveness on the Reduction of Cardiovascular Long-term EventS Unknown status NCT01515878 Phase 4
8 Non Invasive Mechanical Ventilation in Acute Cardiogenic Pulmonary Edema Completed NCT00912158 Phase 4
9 CPAP Versus NPPV in ACPE Completed NCT00446498 Phase 4
10 Non-Invasive Ventilation in Pulmonary Edema Completed NCT00453947 Phase 4
11 OUT-OF-HOSPITAL CPAP STUDY Completed NCT00439075 Phase 4 standard treatment
12 Evaluating Fluid Strategies in Thoracic Surgery Patients Utilizing a Goal Directed Approach Completed NCT02135146 Phase 4 Plasmalyte 3ml/kg/hr group;Plasmalyte 6ml/kg/hr group
13 Randomized, Controlled Trial of Regular Sildenafil Citrate in the Prevention of Altitude Illness Completed NCT00627965 Phase 4 Sildenafil citrate;Placebo
14 Efficacy Study of Riociguat and Its Effects on Exercise Performance and Pulmonary Artery Pressure at High Altitude Completed NCT02024386 Phase 4 Riociguat
15 Acute Chest Pain Treatment and Evaluation (ACTION) Study Completed NCT00434564 Phase 4
16 Diffuse Acute Respiratory Distress Syndrome (ARDS), Recruitment Maneuver, and sRAGE (DAMAGE Study) Completed NCT01600651 Phase 4
17 Beta-Blocker Continuation Versus Interruption in Heart Failure Worsening Completed NCT00162565 Phase 4 beta-blocker treatment
18 Electromyographic Activity of the Respiratory Muscles During Neostigmine or Sugammadex Enhanced Recovery After Neuromuscular Blockade Completed NCT02403063 Phase 4 Sugammadex;Neostigmine;Neostigmine-sugammadex
19 Effect-site Concentration of Remifentanil for Smooth Removal of the Double-lumen Endotracheal Tube Completed NCT02528825 Phase 4 Remifentanil titration
20 Acetazolamide for the Prevention of High Altitude Illness: a Comparison of Dosing Completed NCT01993667 Phase 4 Acetazolamide
21 Nebulized Heparin and Salbutamol in Mechanically Ventilated Patients With AECOPD Completed NCT03333395 Phase 4 Nebulized heparin and salbutamol;Nebulized salbutamol
22 Steroids in Fulminant Hepatic Failure in the Pediatric Age Group Completed NCT02375867 Phase 4 prednisolone;methylprednisolone
23 Erythropoietin in the Prevention of Acute Mountain Sickness Completed NCT01665781 Phase 4 Erythropoietin
24 Restricted Fluid Therapy in Colorectal Surgery Completed NCT03537989 Phase 4 Saline
25 Rate Control in Atrial Fibrillation Completed NCT01655303 Phase 4 Propranolol;Metoprolol;Verapamil;Diltiazem
26 REstrictive Versus LIbEral Fluid Therapy in Major Abdominal Surgery: RELIEF Study Completed NCT01424150 Phase 4
27 Lumbar Plexus Block Upon the Incidence of Ischemic Cardiovascular Events in Elderly Patients With Hip Fracture Completed NCT01961895 Phase 4 Intravenous patient-controlled analgesia
28 Southwest German Interventional Study in Acute Myocardial Infarction III Completed NCT01124890 Phase 4
29 Milrinone Versus Dobutamine in Critically Ill Patients Recruiting NCT03207165 Phase 4 Milrinone;Dobutamine
30 A Randomized Control Trial of Vitamin D Prophylaxis in the Prevention of Hypertensive Disorders of Pregnancy Recruiting NCT02920593 Phase 4 Vitamin D3
31 The Effect of Dexmedetomidine on Airway Complications After Deep or Awake Extubation Recruiting NCT02162433 Phase 4 Normal Saline;Dexmedetomidine
32 Chronic Hypertension and Pregnancy (CHAP) Project Recruiting NCT02299414 Phase 4 Anti-hypertensive therapy
33 Prophylaxis of Ileostomy Closure Site Hernia by Placing Mesh Recruiting NCT02226887 Phase 4
34 Parenteral Antibiotics Compared to Combination of Oral and Parenteral Antibiotics in Colorectal Surgery Prophylaxis Recruiting NCT02505581 Phase 4 Extra dosage - cefuroxime (750mg) I.V;Cefuroxime 750mg oral;Metronidazole 250mg oral;Metronidazole 1,5gr Intravenous;Cefuroxime 1g Intravenous
35 Effect of Acetazolamide on Subclinical High-Altitude Pulmonary Edema Detected by Lung Ultrasonography Active, not recruiting NCT03490916 Phase 4 Acetazolamide;Placebo
36 NAVISTAR® THERMOCOOL® Catheter Post Approval Registry Active, not recruiting NCT00964392 Phase 4
37 MIdazolam Versus MOrphine in Acute Pulmonary Edema (MIMO Trial) Not yet recruiting NCT02856698 Phase 4 Midazolam;Morphine
38 Evaluation of Early CRRT and Beta-blocker InTerventions in Patients With ECMO(ELITE) Not yet recruiting NCT03549923 Phase 4 Esmolol;Standard care
39 Paramedic Initiated Treatment of Sepsis Targeting Out-of-hospital Patients (PITSTOP) Not yet recruiting NCT03068741 Phase 4 Comparison 1: Prehospital Ceftriaxone;Comparison 1: Placebo;Comparison 2: Liberal fluids;Comparison 2: Conservative fluids
40 Normoglycemia and Neurological Outcome Terminated NCT01137773 Phase 4 Insulin;Conventional insulin treatment
41 Different Schemes of Magnesium Sulfate for Preeclampsia Terminated NCT02396030 Phase 4 Magnesium sulfate 50% - 1g/h;Magnesium sulfate 50% - 2g/h
42 Double Blind Randomized Placebo Controlled Trial of Natrecor in Acute Decompensated Heart Failure With Normal EF Withdrawn NCT00505791 Phase 4 Nesiritide
43 High-Dose Aldactone for Treatment of Diuretic Resistant Heart Failure Withdrawn NCT02429388 Phase 4 Spironolactone
44 Bilevel Positive Pressure Ventilation (BIPAP)in Patients With Sleep Disorders Breathing (SDB)and Congestive Heart Failure (CHF):Comparison of Two Diagnostic Methods Unknown status NCT01501734 Phase 3
45 Study of Cabergoline for Prevention of Ovarian Hyperstimulation Syndrome (OHSS) in In Vito Fertilization Cycles and Derivation of OHSS Biomarkers Unknown status NCT01535859 Phase 3 Cabergoline;Placebo
46 Transfusion Requirements in Critically Ill Oncologic Patient Unknown status NCT01648946 Phase 3
47 Concomitant Tracheostomy and Lung Resection Unknown status NCT01053624 Phase 3
48 Single Bolus Recombinant Nonimmunogenic Staphylokinase (FORtelyzin) Versus Single Bolus Tenecteplase (Metalyse) in STEMI Unknown status NCT02301910 Phase 3 Recombinant staphylokinase;Tenecteplase
49 Out-of-Hospital CPAP for Severe Cardiogenic Pulmonary Edema Completed NCT00390442 Phase 3
50 CPAP Versus Bilevel Pressure Support Ventilation in Cardiogenic Pulmonary Edema Completed NCT00213681 Phase 3

Search NIH Clinical Center for Pulmonary Edema

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: pulmonary edema

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Genetic Tests for Pulmonary Edema

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Anatomical Context for Pulmonary Edema

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MalaCards organs/tissues related to Pulmonary Edema:

41
Lung, Heart, Kidney, Brain, Liver, Endothelial, Neutrophil
Sources

Publications for Pulmonary Edema

About this section

Articles related to Pulmonary Edema:

(show top 50) (show all 859)
# Title Authors Year
1
Negative pressure pulmonary edema. ( 29441178 )
2018
2
New insights into the mechanisms of pulmonary edema in acute lung injury. ( 29430449 )
2018
3
Elevated Vasodilatory Cyclases and Shorter Telomere Length Contribute to High-Altitude Pulmonary Edema. ( 29443612 )
2018
4
The Key Roles of Negative Pressure Breathing and Exercise in the Development of Interstitial Pulmonary Edema in Professional Male SCUBA Divers. ( 29299780 )
2018
5
Naloxone-Induced Non-Cardiogenic Pulmonary Edema: A Case Report. ( 29749582 )
2018
6
High-Altitude Acute Pulmonary Edema after 48 Hours in a Ski Station. ( 29871767 )
2018
7
Non-Invasive Mechanical Ventilation Compared to Positive Airway Pressure in Cardiogenic Pulmonary Edema. ( 29859635 )
2018
8
Acute pulmonary edema induced by non-ionic low-osmolar radiographic contrast media. ( 29942165 )
2018
9
Postictal neurogenic pulmonary edema: Case report and brief literature review. ( 29692972 )
2018
10
Refractory Pulmonary Edema and Upper Body Hypoxemia During Veno-Arterial Extracorporeal Membrane Oxygenation-A Case for Atrial Septostomy. ( 29344963 )
2018
11
Regional Negative Pressure Pulmonary Edema with Pulmonary Thromboembolism. ( 29434139 )
2018
12
Predicting cardiogenic pulmonary edema in heart failure patients by using an N-terminal pro-b-type natriuretic peptide (NT-pro BNP) -based score. ( 29408167 )
2018
13
Sequencing the exons of human glucocorticoid receptor (NR3C1) gene in Han Chinese with high-altitude pulmonary edema. ( 29587872 )
2018
14
Neurogenic Pulmonary Edema and Stunned Myocardium in a Patient With Meningioma: A Heart-Brain Cross Talk. ( 29432276 )
2018
15
Identification of Pulmonary Edema in Forensic Autopsy Cases of Sudden Cardiac Death Using Fourier Transform Infrared Microspectroscopy: A Pilot Study. ( 29364657 )
2018
16
Sensitivity and specificity of ultrasound for the diagnosis of acute pulmonary edema: a systematic review and meta-analysis. ( 29400365 )
2018
17
Aortic dissection presenting with acute pulmonary edema. ( 29709400 )
2018
18
Pulmonary Edema and Diastolic Heart Failure in the Perioperative Period. ( 29607222 )
2018
19
Correlation analysis on serum inflammatory cytokine level and neurogenic pulmonary edema for children with severe hand-foot-mouth disease. ( 29724230 )
2018
20
Pulmonary edema post-adenotonsillectomy in children. ( 29915848 )
2018
21
Correction to: Correlation analysis on serum inflammatory cytokine level and neurogenic pulmonary edema for children with severe hand-foot-mouth disease. ( 29907161 )
2018
22
HMOX1 Promoter Microsatellite Polymorphism and High Altitude Pulmonary Edema in Han Chinese Men. ( 29398188 )
2018
23
Thoracic fluid content: a novel parameter for detection of pulmonary edema in parturients with preeclampsia. ( 29936563 )
2018
24
Upfront triple combination therapy-induced pulmonary edema in a case of pulmonary arterial hypertension associated with Sjogren's syndrome. ( 29276674 )
2018
25
Transcriptomic profiling reveals gene expression kinetics in patients with hypoxia and high altitude pulmonary edema. ( 29366758 )
2018
26
Diving, Immersion Pulmonary Edema ( 29763028 )
2018
27
Treating acute hypertensive cardiogenic pulmonary edema with high-dose nitroglycerin. ( 29942881 )
2018
28
High altitude trekking after lung transplantation: a prospective study using lung ultrasound to detect comets tails for interstitial pulmonary edema in lung transplant recipients and healthy volunteers. ( 29928768 )
2018
29
Recognition of Sympathetic Crashing Acute Pulmonary Edema (SCAPE) and use of high-dose nitroglycerin infusion. ( 29776826 )
2018
30
Mast cells contribute to Enterovirus 71 infection-induced pulmonary edema in neonatal mice. ( 29765110 )
2018
31
Effects of Medium Molecular Weight Heparinyl Arginine on Scorpion Venom-induced Pulmonary Edema in Rats. ( 29695557 )
2018
32
Pressure support ventilation vs Continuous positive airway pressure for treating of acute cardiogenic pulmonary edema: A pilot study. ( 29702222 )
2018
33
Acute noncardiogenic pulmonary edema after neostigmine administration during the recovery period of general anesthesia: A case report. ( 29794728 )
2018
34
Acute pulmonary edema caused by takotsubo cardiomyopathy in a pregnant woman undergoing transvaginal cervical cerclage: A case report. ( 28072695 )
2017
35
A Morphological and Quantitative Analysis of Lung CT Scan in Patients With Acute Respiratory Distress Syndrome and in Cardiogenic Pulmonary Edema. ( 29161936 )
2017
36
Unilateral High-Altitude Pulmonary Edema. ( 28837778 )
2017
37
The need for systematic diagnosis of exercise-induced respiratory syndromes: the example of swimming-induced pulmonary edema. ( 28820003 )
2017
38
16-Year-Old Female Near Hanging With Negative Pressure Pulmonary Edema. ( 28089063 )
2017
39
Pulmonary Edema After Near Hanging: An Insight. ( 28886777 )
2017
40
Severe pulmonary edema following hyperbaric oxygen therapy for acute carbon monoxide poisoning: a case report and clinical experience. ( 28779586 )
2017
41
Swimming-induced pulmonary edema in a tropical climate: a case report. ( 28779587 )
2017
42
Reentry High Altitude Pulmonary Edema in the Himalayas. ( 28910201 )
2017
43
Targeting resolution of pulmonary edema in primary graft dysfunction after lung transplantation: Is inhaled AP301 the answer? ( 29198870 )
2017
44
Clinical Features of Patients with Diffuse Alveolar Hemorrhage due to Negative-Pressure Pulmonary Edema. ( 28455784 )
2017
45
High peak PaO2 values are associated with adverse outcome in critically ill patients treated with non-invasive ventilation for acute cardogenic pulmonary edema and pneumonia. ( 28884567 )
2017
46
Neurogenic Pulmonary Edema Complicating ECT. ( 29166318 )
2017
47
High-Altitude Pulmonary Edema in Mountain Community Residents. ( 28846035 )
2017
48
Inhaled AP301 for treatment of pulmonary edema in mechanically ventilated patients with acute respiratory distress syndrome: a phase IIa randomized placebo-controlled trial. ( 28750677 )
2017
49
Management of Neurogenic Pulmonary Edema and Differential Hypoxemia in an Adult Supported on Venoarterial Extracorporeal Membrane Oxygenation. ( 28764986 )
2017
50
Pulmonary edema following central nervous system lesions induced by a non- mouse-adapted EV71 strain in neonatal BALB/c mice. ( 29282065 )
2017
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Variations for Pulmonary Edema

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Expression for Pulmonary Edema

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Search GEO for disease gene expression data for Pulmonary Edema.
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Pathways for Pulmonary Edema

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Pathways related to Pulmonary Edema according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Immune response IL-23 signaling pathway 22
Show member pathways
 12.54 F2 IL10 IL1B NOS3 TNF
2
Insulin receptor recycling 66
Show member pathways
 12.41 CFTR CXCL8 HMOX1 NOS3
3
IL-17 Family Signaling Pathways 65
Show member pathways
 12.27 CFTR CXCL8 IL1B TNF
4
Folate Metabolism 1
Show member pathways
 12.27 CRP F2 ICAM1 IL1B TNF
5
IL-1 Family Signaling Pathways 65
Show member pathways
 12.16 CFTR CXCL8 EDN1 HMOX1 IL1B TNF
6
Bacterial infections in CF airways 22
Show member pathways
 12.14 CFTR CXCL8 IL1B TNF
7
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.13 CXCL8 IL10 IL1B TNF
8
Spinal Cord Injury 1
11.98 CXCL8 ICAM1 IL1B TNF
9
TNF signaling pathway 37
11.92 EDN1 ICAM1 IL1B TNF
10
Amoebiasis 37
11.85 CXCL8 IL10 IL1B TNF
11
HIF-1 signaling pathway 37
11.84 EDN1 HMOX1 NOS3
12
NF-kappa B signaling pathway 37
11.84 CXCL8 ICAM1 IL1B TNF
13
Cytokine production by Th17 cells in CF (Mouse model) 22
Show member pathways
 11.8 CFTR CXCL8 ICAM1
14
Rheumatoid arthritis 37
11.8 CXCL8 ICAM1 IL1B TNF
15
Angiogenesis (CST) 4
11.78 HMOX1 NOS3 REN
16
Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics 61
Show member pathways
 11.73 ACE NOS3 REN
17
Innate Lymphoid Cell Differentiation Pathways 65
11.72 IL10 IL1B TNF
18
Pertussis 37
11.71 CXCL8 IL10 IL1B TNF
19
Interleukin-4 and 13 signaling 66
11.69 CXCL8 HMOX1 ICAM1 IL10 IL1B TNF
20
Dendritic Cells Developmental Lineage Pathway 65
11.68 IL10 IL1B TNF
21
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.6 CXCL8 ICAM1 IL1B TNF
22
Lung fibrosis 1
11.57 CXCL8 EDN1 HMOX1 IL1B TNF
23
Legionellosis 37
11.54 CXCL8 IL1B TNF
24
AGE-RAGE signaling pathway in diabetic complications 37
11.43 CXCL8 EDN1 ICAM1 IL1B NOS3 TNF
25
Interleukin-10 signaling 66
11.41 CXCL8 ICAM1 IL10 IL1B TNF
26
Malaria 37
11.34 CXCL8 ICAM1 IL10 IL1B TNF
27
African trypanosomiasis 37
11.32 ICAM1 IL10 IL1B TNF
28
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
11.31 CXCL8 HMOX1 NOS3
29
Fluid shear stress and atherosclerosis 37
11.31 EDN1 HMOX1 ICAM1 IL1B NOS3 TNF
30
IL-10 Pathway 64
11.3 HMOX1 IL10 IL1B TNF
31
Cytokines and Inflammatory Response 1
11.24 IL10 IL1B TNF
32
IL1 and megakaryocytes in obesity 1
11.15 F2 ICAM1 IL1B
33
Overview of nanoparticle effects 1
10.98 CRP CXCL8 HMOX1 TNF
34
LDL Oxidation in Atherogenesis 64
10.89 ICAM1 IL1B TNF
35
NO-dependent CFTR activation (normal and CF) 22
10.77 CFTR NOS3
Sources

GO Terms for Pulmonary Edema

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Cellular components related to Pulmonary Edema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 ACE CRP CXCL8 EDN1 F2 IL10
2 external side of plasma membrane GO:0009897 9.46 ACE F2 ICAM1 TNF
3 extracellular space GO:0005615 9.44 ACE CRP CXCL8 EDN1 F2 HMOX1

Biological processes related to Pulmonary Edema according to GeneCards Suite gene sharing:

(show all 47)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.98 CRP CXCL8 IL10 IL1B TNF
2 leukocyte migration GO:0050900 9.93 F2 ICAM1 IL1B TNF
3 response to organic substance GO:0010033 9.88 IL10 REN TNF
4 positive regulation of angiogenesis GO:0045766 9.86 CXCL8 HMOX1 IL1B NOS3
5 cellular response to interleukin-1 GO:0071347 9.85 CXCL8 EDN1 ICAM1
6 response to insulin GO:0032868 9.85 ICAM1 IL10 TRPV4
7 cellular response to lipopolysaccharide GO:0071222 9.85 CXCL8 ICAM1 IL10 TNF
8 cytokine-mediated signaling pathway GO:0019221 9.85 CXCL8 HMOX1 ICAM1 IL10 IL1B TNF
9 positive regulation of JNK cascade GO:0046330 9.83 IL1B TNF TRPV4
10 neutrophil chemotaxis GO:0030593 9.82 CXCL8 EDN1 IL1B
11 cellular response to drug GO:0035690 9.81 EDN1 IL1B REN
12 positive regulation of smooth muscle cell proliferation GO:0048661 9.79 EDN1 HMOX1 TNF
13 positive regulation of DNA binding transcription factor activity GO:0051091 9.78 EDN1 IL10 IL1B TNF
14 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.71 HMOX1 ICAM1 NOS3
15 amyloid-beta metabolic process GO:0050435 9.7 ACE REN
16 regulation of blood vessel diameter GO:0097746 9.7 ACE NPPB
17 regulation of signaling receptor activity GO:0010469 9.7 CXCL8 EDN1 F2 IL10 IL1B NPPB
18 positive regulation of urine volume GO:0035810 9.69 EDN1 NPPB
19 negative regulation of calcium ion transport GO:0051926 9.69 ICAM1 NOS3
20 regulation of blood coagulation GO:0030193 9.69 F2 SERPINC1
21 response to molecule of bacterial origin GO:0002237 9.68 CXCL8 IL10
22 angiotensin maturation GO:0002003 9.68 ACE REN
23 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.68 IL1B TRPV4
24 negative regulation of lipid storage GO:0010888 9.67 CRP TNF
25 negative regulation of platelet activation GO:0010544 9.67 F2 NOS3
26 lipopolysaccharide-mediated signaling pathway GO:0031663 9.67 IL1B NOS3 TNF
27 multicellular organismal water homeostasis GO:0050891 9.66 CFTR TRPV4
28 body fluid secretion GO:0007589 9.66 EDN1 NPPB
29 acute inflammatory response to antigenic stimulus GO:0002438 9.65 ICAM1 SERPINC1
30 endothelial cell apoptotic process GO:0072577 9.65 IL10 TNF
31 regulation of establishment of endothelial barrier GO:1903140 9.63 IL1B TNF
32 positive regulation of prostaglandin secretion GO:0032308 9.62 EDN1 IL1B
33 negative regulation of cytokine secretion involved in immune response GO:0002740 9.61 IL10 TNF
34 regulation of blood vessel size GO:0050880 9.61 EDN1 NOS3 NPPB
35 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.6 EDN1 NOS3
36 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.59 ICAM1 TNF
37 positive regulation of fever generation GO:0031622 9.58 IL1B TNF
38 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.58 IL10 IL1B TNF
39 sequestering of triglyceride GO:0030730 9.57 IL1B TNF
40 positive regulation of nitric oxide biosynthetic process GO:0045429 9.56 EDN1 ICAM1 IL1B TNF
41 receptor biosynthetic process GO:0032800 9.52 IL10 TNF
42 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.51 IL1B TNF
43 positive regulation of chemokine biosynthetic process GO:0045080 9.5 HMOX1 IL1B TNF
44 response to lipopolysaccharide GO:0032496 9.5 CXCL8 EDN1 ICAM1 IL10 IL1B NOS3
45 smooth muscle hyperplasia GO:0014806 9.46 HMOX1 NOS3
46 regulation of blood pressure GO:0008217 9.1 ACE EDN1 HMOX1 NOS3 NPPB REN
47 negative regulation of cell proliferation GO:0008285 10.02 CXCL8 HMOX1 IL10 IL1B NOS3

Molecular functions related to Pulmonary Edema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.86 AQP5 CFTR CRP CXCL8 EDN1 F2
2 cytokine activity GO:0005125 9.02 CXCL8 EDN1 IL10 IL1B TNF
Sources

Sources for Pulmonary Edema

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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