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MCID: PLM010
MIFTS: 55

Pulmonary Edema

Categories: Cardiovascular diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Pulmonary Edema

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MalaCards integrated aliases for Pulmonary Edema:

Name: Pulmonary Edema 12 43 15 17 71

Classifications:

MalaCards categories:
Anatomical: Respiratory diseases Cardiovascular diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:11396
MeSH 43 D011654
NCIt 49 C26868
SNOMED-CT 67 19242006
ICD10 32 J81 J81.1
UMLS 71 C0034063
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Summaries for Pulmonary Edema

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MalaCards based summary : Pulmonary Edema is related to acute mountain sickness and adult respiratory distress syndrome, and has symptoms including edema, hemoptysis and peau d'orange. An important gene associated with Pulmonary Edema is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Immune response IL-23 signaling pathway. The drugs Simvastatin and Clarithromycin have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and kidney, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 74 Pulmonary edema is fluid accumulation in the tissue and air spaces of the lungs. It leads to impaired... more...

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Related Diseases for Pulmonary Edema

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Diseases related to Pulmonary Edema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 982)
# Related Disease Score Top Affiliating Genes
1 acute mountain sickness 34.3 PIK3C2A NOS3 EDN1 ACE
2 adult respiratory distress syndrome 33.7 TNF IL1B IL10 FGF7 F2 CXCL8
3 chronic mountain sickness 33.3 NPPB NOS3 EDN1
4 silicosis 32.3 TNF IL1B IL10 HMOX1 CXCL8 ACE
5 cardiogenic shock 31.6 NPPB CRP
6 mitral valve insufficiency 31.5 TNNI3 REN NPPB CRP ACE
7 mitral valve stenosis 31.2 SERPINC1 REN NPPB F2 CRP ACE
8 chronic thromboembolic pulmonary hypertension 31.2 NPPB EDN1 CRP
9 pheochromocytoma 31.2 TNF REN OXT EDN1 ACE
10 pulmonary embolism 31.2 TNNI3 SERPINC1 NPPB F2 CRP ACE
11 acute kidney failure 31.1 REN PIK3C2A F2
12 mouth disease 31.1 NPPB IL1B IL10 CRP
13 congestive heart failure 31.1 TNNI3 TNF REN PIK3C2A NPPB NOS3
14 pulmonary fibrosis 31.0 IL1B FGF7 EDN1 CXCL8
15 aspiration pneumonia 31.0 PIK3C2A F2 CRP ACE
16 intracranial hypertension 31.0 TNF SERPINC1 NPPB IL1B F2
17 end stage renal failure 31.0 TNF REN NPPB CRP ACE
18 respiratory failure 30.9 TNF REN PIK3C2A NPPB IL1B IL10
19 ischemia 30.9 PIK3C2A NPPB NOS3 ICAM1 HMOX1 EDN1
20 brain edema 30.9 IL1B HMOX1 CRP AQP5
21 patent ductus arteriosus 1 30.9 NPPB EDN1 CRP ACE
22 bronchopneumonia 30.9 TNF IL10 CXCL8 CRP
23 kidney disease 30.8 TNF REN NPPB NOS3 HMOX1 EDN1
24 poliomyelitis 30.8 TNF IL10 ICAM1
25 newborn respiratory distress syndrome 30.8 IL1B FGF7 CXCL8
26 bronchiolitis 30.8 TNF IL10 CXCL8 CRP
27 coronary heart disease 1 30.8 NPPB NOS3 EDN1 CRP ACE
28 diastolic heart failure 30.8 TNNI3 REN NPPB NOS3 ACE
29 atrioventricular block 30.8 TNNI3 PIK3C2A NPPB ACE
30 acute pancreatitis 30.8 TNF IL1B IL10 CXCL8 CRP
31 toxic shock syndrome 30.8 TNF SERPINC1 IL1B IL10 CXCL8 CRP
32 uremia 30.8 TNF REN CRP ACE
33 infective endocarditis 30.8 TNNI3 TNF F2 CRP
34 rheumatic fever 30.8 TNF NPPB IL10 ICAM1 ACE
35 aortic valve insufficiency 30.7 REN NPPB CRP ACE
36 allergic hypersensitivity disease 30.7 TNF IL10 ICAM1 CXCL8
37 plasmodium falciparum malaria 30.7 TNF IL10 ICAM1 CRP
38 right bundle branch block 30.7 TNNI3 NPPB ACE
39 bacterial pneumonia 30.7 TNF IL10 CXCL8 CRP
40 laryngitis 30.7 TNF IL1B CRP
41 drug allergy 30.7 F2 CRP ACE
42 acute myocardial infarction 30.7 TNNI3 SERPINC1 REN PIK3C2A NPPB EDN1
43 cardiac tamponade 30.7 TNNI3 REN PIK3C2A NPPB F2 CRP
44 cardiac arrest 30.6 REN PIK3C2A OXT NPPB ICAM1 HMOX1
45 myocardial stunning 30.6 TNNI3 SERPINC1 EDN1 ACE
46 pulmonary emphysema 30.6 NOS3 HMOX1 FGF7 CXCL8
47 anterolateral myocardial infarction 30.6 NPPB ACE
48 renal artery disease 30.6 REN NOS3 CRP ACE
49 chickenpox 30.6 TNF IL10 CRP
50 rheumatic heart disease 30.6 TNF NPPB IL1B IL10 ACE

Graphical network of the top 20 diseases related to Pulmonary Edema:



Diseases related to Pulmonary Edema
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Symptoms & Phenotypes for Pulmonary Edema

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UMLS symptoms related to Pulmonary Edema:


edema, hemoptysis, peau d'orange

GenomeRNAi Phenotypes related to Pulmonary Edema according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.88 ACE CXCL8 F2 HMOX1 ICAM1 IL10
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.88 ACE CXCL8 F2 HMOX1 ICAM1 IL10

MGI Mouse Phenotypes related to Pulmonary Edema:

45 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.41 ACE CRP EDN1 F2 HMOX1 ICAM1
2 homeostasis/metabolism MP:0005376 10.36 ACE AQP5 CRP EDN1 F2 FGF7
3 growth/size/body region MP:0005378 10.32 ACE AQP5 EDN1 F2 FGF7 HMOX1
4 behavior/neurological MP:0005386 10.3 ACE AQP5 F2 FGF7 HMOX1 IL10
5 mortality/aging MP:0010768 10.24 ACE AQP5 EDN1 F2 HMOX1 ICAM1
6 hematopoietic system MP:0005397 10.23 ACE F2 FGF7 HMOX1 ICAM1 IL10
7 immune system MP:0005387 10.22 ACE CRP F2 FGF7 HMOX1 ICAM1
8 digestive/alimentary MP:0005381 10.1 AQP5 EDN1 F2 ICAM1 IL10 NOS3
9 nervous system MP:0003631 10.03 EDN1 F2 FGF7 ICAM1 IL10 IL1B
10 muscle MP:0005369 10.02 AQP5 EDN1 HMOX1 ICAM1 IL10 NOS3
11 renal/urinary system MP:0005367 9.85 ACE EDN1 FGF7 HMOX1 NOS3 OXT
12 reproductive system MP:0005389 9.65 ACE F2 FGF7 HMOX1 IL10 NOS3
13 respiratory system MP:0005388 9.23 AQP5 F2 HMOX1 IL10 NOS3 TNF
Sources

Drugs & Therapeutics for Pulmonary Edema

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Drugs for Pulmonary Edema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 266)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Simvastatin Approved Phase 4 79902-63-9 54454
2
Clarithromycin Approved Phase 4 81103-11-9 84029
3
Remifentanil Approved Phase 4 132875-61-7 60815
4
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
5
Riociguat Approved Phase 4 625115-55-1
6
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
7
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
8
Phenoxybenzamine Approved Phase 4 59-96-1 4768
9
Doxazosin Approved Phase 4 74191-85-8 3157
10
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
11
Morphine Approved, Investigational Phase 4 57-27-2 5288826
12
Nifedipine Approved Phase 4 21829-25-4 4485
13
Dobutamine Approved Phase 4 34368-04-2 36811
14
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
15
Ibuprofen Approved Phase 4 15687-27-1 3672
16
Labetalol Approved Phase 4 36894-69-6 3869
17
Oxytocin Approved, Vet_approved Phase 4 50-56-6 439302 53477758
18
Azithromycin Approved Phase 4 83905-01-5 55185 447043
19
Esmolol Approved Phase 4 81147-92-4, 103598-03-4 59768
20
Acetaminophen Approved Phase 4 103-90-2 1983
21
Milrinone Approved Phase 4 78415-72-2 4197
22
Sotalol Approved Phase 4 959-24-0, 3930-20-9 5253
23
Lisinopril Approved, Investigational Phase 4 83915-83-7, 76547-98-3 5362119
24
Acetazolamide Approved, Vet_approved Phase 4 59-66-5 1986
25
tannic acid Approved Phase 4 1401-55-4
26
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
27
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
28
Amlodipine Approved Phase 4 88150-42-9 2162
29
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198
30
Zinc Approved, Investigational Phase 4 7440-66-6 32051
31
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
32 Hypolipidemic Agents Phase 4
33 Anticholesteremic Agents Phase 4
34 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
35 Lipid Regulating Agents Phase 4
36 Rosuvastatin Calcium Phase 4 147098-20-2
37 Plasma-lyte 148 Phase 4
38 Ophthalmic Solutions Phase 4
39 Chelating Agents Phase 4
40 Cytochrome P-450 CYP3A Inhibitors Phase 4
41 Cytochrome P-450 Enzyme Inhibitors Phase 4
42 Anti-Bacterial Agents Phase 4
43 Antibiotics, Antitubercular Phase 4
44 Performance-Enhancing Substances Phase 4
45 Neuromuscular Nondepolarizing Agents Phase 4
46 Cholinergic Agents Phase 4
47 Cholinesterase Inhibitors Phase 4
48
Glycopyrrolate Phase 4 596-51-0 3494
49 Cola Phase 4
50 Anti-Inflammatory Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 384)
# Name Status NCT ID Phase Drugs
1 Impact of Fluid Resuscitation Therapy on Pulmonary Edema as Measured by Alveolar Fluid Clearance in Patients With Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT01763853 Phase 4 4% albumin
2 Remifentanil for c-Section With General Anesthesia in Severe Preeclamptic Patients Unknown status NCT00567957 Phase 4 Remifentanil;Saline
3 Non-Invasive Positive Pressure Mask Ventilation vs Extrathoracic Biphasic Cuirass Ventilation in Patients With Acute Respiratory Failure: A Randomized Prospective Study. Unknown status NCT00331656 Phase 4
4 MICROS-Pilot Study Microcirculation In Acute Coronary Syndromes; Effect of Pre-treatment of High Dose Rosuvastatin on Coronary Microcirculation in Primary PCI Unknown status NCT01382472 Phase 4 Rosuvastatin;Simvastatin
5 Effects of Atorvastatin Treatment on Left Ventricular Diastolic Function in Peritoneal Dialysis Patients (ALEVENT) Unknown status NCT01503671 Phase 4 Atorvastatin
6 CPAP Versus BiPAP in Acute Cardiogenic Pulmonary Edema: Experience With 129 Patients Completed NCT00912158 Phase 4
7 Continuous Positive Airway Pressure Versus Non-Invasive Positive Pressure Support Ventilation in Acute Cardiogenic Pulmonary Oedema: a Prospective Randomised Multicentre Trial. Completed NCT00446498 Phase 4
8 Randomised Controlled Comparison of Continuous Positive Airway Pressure (CPAP) With Standard Treatment in Out-of-hospital Patients With Acute Cardiogenic Pulmonary Edema. Completed NCT00439075 Phase 4 standard treatment
9 Non Invasive Positive Airway Pressure And Risk Of Myocardial Infarction In Acute Cardiogenic Pulmonary Edema: Continuous Positive Airway Pressure Vs Non Invasive Positive Pressure Ventilation Completed NCT00453947 Phase 4
10 Evaluating Fluid Strategies in Thoracic Surgery Patients Utilizing a Goal Directed Approach Completed NCT02135146 Phase 4 Plasmalyte 3ml/kg/hr group;Plasmalyte 6ml/kg/hr group
11 Randomized, Controlled Trial of Regular Sildenafil Citrate in the Prevention of Altitude Illness Completed NCT00627965 Phase 4 Sildenafil citrate;Placebo
12 Clarithromycin as Immunomodulatory Therapy for the Management of Septic Syndrome by Ventilator-Associated Pneumonia Completed NCT00297674 Phase 4 Intravenous Clarithromycin
13 Effect-site Concentration of Remifentanil for Smooth Removal of the Double-lumen Endotracheal Tube Completed NCT02528825 Phase 4 Remifentanil titration
14 Acetazolamide for the Prevention of High Altitude Illness: a Comparison of Dosing Completed NCT01993667 Phase 4 Low Dose Acetazolamide;Normal Dose Acetazolamide
15 The Effect of Riociguat on Gas Exchange, Exercise Performance, and Pulmonary Artery Pressure During Acute Altitude Exposure Completed NCT02024386 Phase 4 Riociguat
16 Impact of Aggressive Versus Standard Drainage Regimen Using a Long Term Indwelling Pleural Catheter on the Incidence of Auto-Pleurodesis in Patients With Malignant Pleural Effusions Completed NCT00978939 Phase 4
17 Electromyographic Activity of the Diaphragm and of the Rectus Abdominis and Intercostal Muscles During Neostigmine, Sugammadex, or Neostigmine-sugammadex Enhanced Recovery After Neuromuscular Blockade With Rocuronium. A Randomised Controlled Study in Healthy Volunteers Completed NCT02403063 Phase 4 Sugammadex;Neostigmine;Neostigmine-sugammadex
18 Short Term Physiological Effects of Nasal High Oxygen Flow vs Low Oxygen Flow and Noninvasive Ventilation (NIV) on Respiratory Mechanics Completed NCT02363920 Phase 4
19 Effects Of A Recruitment Maneuver On Plasma Levels of sRAGE, The Soluble Form of The Receptor For Advanced Glycation End Products, In Patients With Diffuse Acute Respiratory Distress Syndrome (ARDS) Completed NCT01600651 Phase 4
20 Albumin vs. Plasma for PEdiAtric pRiming Trial Completed NCT02738190 Phase 4 Albumin
21 Restrictive vs. Liberal Oxygen Therapy for Trauma Patients. PILOT: The TRAUMOX Trial Completed NCT03491644 Phase 4 Titrated Oxygen;Liberal Oxygen
22 Pheochromocytoma Randomised Study Comparing Adrenoreceptor Inhibiting Agents for Preoperative Treatment Completed NCT01379898 Phase 4 Phenoxybenzamine;Doxazosin
23 Perioperative Fluid Treatment in Colorectal Surgery Completed NCT03537989 Phase 4 Saline
24 Study Design and Rationale of "A Multicenter, Open-Labeled, Randomized Controlled Trial Comparing MIdazolam Versus MOrphine in Acute Pulmonary Edema": MIMO Trial Recruiting NCT02856698 Phase 4 Midazolam;Morphine
25 Impact of Obstructive Sleep Apnea Treatment on Cardiovascular Events in Patients With Acute Cardiogenic Pulmonary Edema: a Multicenter Randomized Controlled Study (CPAP-CARE STUDY). Recruiting NCT03936751 Phase 4
26 A Pragmatic Multicenter Randomized Clinical Trial (RCT) of Antihypertensive Therapy for Mild Chronic Hypertension During Pregnancy: Chronic Hypertension and Pregnancy (CHAP) Project Recruiting NCT02299414 Phase 4 Anti-hypertensive therapy
27 Impact of Antichlamydial Treatment on the Rate of Preeclampsia Among Egyptian Primigravidae: a Randomized Controlled Trial Recruiting NCT03233880 Phase 4 Azithromycin 1gm
28 Impact of Early CRRT Intervention in Patients Receiving VA-ECMO Support on 30-day Mortality: A Randomized Controlled Trial Recruiting NCT03549923 Phase 4 Esmolol;Standard care
29 Effect of Non-steroidal Anti-inflammatory Use on Blood Pressure in Women With Hypertensive Disorders of Pregnancy: A Randomized Open Label Trial Recruiting NCT03824119 Phase 4 Ibuprofen 600 mg
30 Comparison of Milrinone Versus Dobutamine in a Heterogeneous Population of Critically Ill Patients Recruiting NCT03207165 Phase 4 Milrinone;Dobutamine
31 Continued Versus Discontinued Oxytocin Stimulation of Labour in a Double-blind Randomised Controlled Trial Recruiting NCT02553226 Phase 4 Oxytocin;Placebo
32 A Pilot and Feasibility Study to Determine if a Common Atrial Fibrillation Risk Locus Modulates Differential Response to Antiarrhythmic Drugs Recruiting NCT02347111 Phase 4 Flecainide;Sotalol
33 Prophylactic Lisinopril to Prevent Anthracycline Induced Left Ventricular Systolic Dysfunction (PLAID) Study. Not yet recruiting NCT03392740 Phase 4 Lisinopril;Placebo Oral Tablet
34 A Prospective, Double-blind, Randomized, Placebo-controlled Trial of Acetazolamide on Subclinical High-Altitude Pulmonary Edema Detected by Lung Ultrasonography Terminated NCT03490916 Phase 4 Acetazolamide;Placebo
35 Cardiovascular and Metabolic Physiological Adaptations to Intermittent Hypoxia. Physiological Aspects and Expression of Receptors and Cellular Mediators Terminated NCT02058823 Phase 4 Placebo;Placebo;Valsartan;Amlodipine
36 Does Maintenance of Normoglycemia Change Neurological Outcome in Patients Recovering From Traumatic Brain Injury and Subarachnoid or Intraparenchymal Hemorrhage? Terminated NCT01137773 Phase 4 Insulin;Conventional insulin treatment
37 Intravenous Isosorbide Dinitrate Versus Sublingual Isosorbide Dinitrate for the Relief of Acute Anginal Episodes in Acute Coronary Syndrome (ACS) Patients Withdrawn NCT00337116 Phase 4 iso sorbide dinitrate iv bolus or s/l
38 High-Dose Aldactone for Treatment of Diuretic Resistant Heart Failure Withdrawn NCT02429388 Phase 4 Spironolactone
39 Treatment of Asymptomatic Fluid Overload in Peritoneal Dialysis Patients Withdrawn NCT02168283 Phase 4
40 Double Blind Randomized Placebo Controlled Trial of Natrecor in Patients Hospitalized for Decompensated Heart Failure in the Presence of a Normal Left Ventricular Ejection Fraction Withdrawn NCT00505791 Phase 4 Nesiritide
41 Non Invasive Ventilation in Acute Asthma Unknown status NCT00510991 Phase 3
42 Bilevel Positive Pressure Ventilation (BIPAP)in Patients With Sleep Disorders Breathing (SDB)and Congestive Heart Failure (CHF):Comparison of Two Diagnostic Methods Unknown status NCT01501734 Phase 3
43 A Study to Evaluate the Effectiveness of Induced Diuresis With Matched Hydration Therapy Compared to Standard Overnight Hydration in the Prevention of Contrast Induced Nephropathy -MYTHOS Study Unknown status NCT00702728 Phase 3 Furosemide and matched saline hydration;isotonic saline solution
44 CPAP Boussignac Versus Bilevel Pressure Support Ventilation in Severe Acute Cardiogenic Pulmonary Edema Completed NCT00213681 Phase 3
45 Effect of Continuous Positive Airway Pressure as a First Line Therapy in Out-of-Hospital Management of Severe Cardiogenic Pulmonary Edema Completed NCT00390442 Phase 3
46 Effect of Continuous Positive Airway Pressure on Short Term Inhospital Prognosis for Acute Pulmonary Edema Completed NCT00554580 Phase 3
47 Non-Invasive Ventilation Versus Continuous Positive Airway Pressure in Cardiogenic Pulmonary Edema: a Multicentre Study Completed NCT00785174 Phase 3
48 Restrictive Versus Liberal Fresh Frozen Plasma Transfusion Prior to Low-Risk Invasive Procedures in Hospitalized Patients. Completed NCT00953901 Phase 3 Fresh Frozen Plasma Transfusion
49 Randomized Clinical Trial of the Beneficial Effects of Antenatal Magnesium Sulfate (BEAM) Completed NCT00014989 Phase 3 magnesium sulfate
50 Restricted Intravenous Fluid Regime Effects on Immunological Indicators of Elderly Patients Operated for Abdominal Cancer Completed NCT01399814 Phase 3

Search NIH Clinical Center for Pulmonary Edema

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Bumetanide
Ethacrynate Sodium
Ethacrynic Acid
Furosemide
Mannitol hexanitrate
torsemide

Cochrane evidence based reviews: pulmonary edema

Sources

Genetic Tests for Pulmonary Edema

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Sources

Anatomical Context for Pulmonary Edema

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MalaCards organs/tissues related to Pulmonary Edema:

40
Lung, Heart, Kidney, Endothelial, Liver, Brain, Neutrophil
Sources

Publications for Pulmonary Edema

About this section

Articles related to Pulmonary Edema:

(show top 50) (show all 14355)
# Title Authors PMID Year
1
Clinical features and outcomes in patients with pulmonary complications during pregnancy and peripartum. 61
30149738 2020
2
A Morphological and Quantitative Analysis of Lung CT Scan in Patients With Acute Respiratory Distress Syndrome and in Cardiogenic Pulmonary Edema. 61
29161936 2020
3
Lung tissue extracellular matrix-derived hydrogels protect against radiation-induced lung injury by suppressing epithelial-mesenchymal transition. 61
31490023 2020
4
Pulmonary Edema in the Acute Stage of Rheumatic Fever Treated with Double-Valve Replacement in a Pediatric Patient. 61
31984164 2020
5
Choking agents and chlorine gas - History, pathophysiology, clinical effects and treatment. 61
31811912 2020
6
Outcome after fetoscopic laser coagulation in twin-twin transfusion syndrome - is the survival rate of at least one child at 6 months of age dependent on preoperative cervical length and preterm prelabour rupture of fetal membranes? 61
30196741 2020
7
Respiratory complications after adenotonsillectomy in high-risk children with obstructive sleep apnea: A retrospective cohort study. 61
31587265 2020
8
Thiamine Deficiency in a Nondrinker and Secondary Pulmonary Edema after Thiamine Replenishment. 61
31534090 2020
9
From bedside to bench: lung ultrasound for the assessment of pulmonary edema in animal models. 61
32009189 2020
10
A single cystatin C determination before coronary angiography can predict short and long-term adverse events. 61
31619362 2020
11
Protective anti-inflammatory activity of tovophyllin A against acute lung injury and its potential cytotoxicity to epithelial lung and breast carcinomas. 61
31218570 2020
12
High-Altitude Decompression Sickness Treated with Hyperbaric Therapy and Extracorporeal Oxygenation. 61
31980050 2020
13
The protective effects of Thalictrum minus L. on lipopolysaccharide-induced acute lung injury. 61
31669667 2020
14
Imaging findings of pulmonary edema: Part 1. Cardiogenic pulmonary edema and acute respiratory distress syndrome. 61
31226879 2020
15
Imaging findings of pulmonary edema: Part 2. Infrequent or unusual pulmonary edema with definitive imaging findings. 61
31237773 2020
16
R-spondin 2 mediates neutrophil egress into the alveolar space through increased lung permeability. 61
32019591 2020
17
Effect of noninvasive ventilation on intubation risk in prehospital patients with acute cardiogenic pulmonary edema: a retrospective study. 61
31295150 2020
18
Unexpected vincristine-induced systemic capillary leak syndrome in patients with Wilm's tumor: A single institution experience. 61
31868068 2020
19
Dose-Dependent Association of Gabapentinoids with Pulmonary Complications After Total Hip and Knee Arthroplasties. 61
31804238 2020
20
Positive Pressure Ventilation in Cardiogenic Shock: Review of the Evidence and Practical Advice for Patients With Mechanical Circulatory Support. 61
32036870 2020
21
L6H9 attenuates LPS-induced acute lung injury in rats through targeting MD2. 61
31693211 2020
22
[When should unilateral renal stenosis not be dilated ?] 61
32022493 2020
23
Activation of Hypoxia-Inducible Factor-1α Via Succinate Dehydrogenase Pathway During Acute Lung Injury Induced by Trauma/Hemorrhagic Shock. 61
31259781 2020
24
Evaluation of atrial natriuretic peptide and cardiac troponin I concentrations for assessment of disease severity in dogs with naturally occurring mitral valve disease. 61
31961274 2020
25
Hyperacute graft dysfunction in an orthotopic heart transplant in the presence of non-HLA antibodies. 61
31400258 2020
26
Outcomes intensive care unit placement following pediatric adenotonsillectomy. 61
31704575 2020
27
Pulmonary amniotic fluid embolism in a rhesus macaque (Macaca mulatta). 61
31742695 2020
28
Acute Pulmonary Edema: A Rare Cause of Dyspnea After Electrical Cardioversion. 61
31973957 2020
29
Feasibility, Effectiveness and Safety of Prehospital Intravenous Bolus Dose Nitroglycerin in Patients with Acute Pulmonary Edema. 61
31900011 2020
30
Maternal pulmonary edema after 46 h of ritodrine hydrochloride administration: A case report. 61
31956518 2020
31
Point-of-Care Ultrasound-A New Option for Early Quantitative Assessment of Pulmonary Edema. 61
31575429 2020
32
Radiological Incidence of Unilateral Pulmonary Edema After Minimally Invasive Cardiac Surgery. 61
31405722 2020
33
Risk factors of pulmonary edema in women with preeclampsia from south India: a case-control study. 61
31932700 2020
34
Early Peritoneal Dialysis Ameliorates Blast Lung Injury by Alleviating Pulmonary Edema and Inflammation. 61
30741852 2020
35
Incidence of negative-pressure pulmonary edema following sugammadex administration during anesthesia emergence: A pilot audit of 27,498 general anesthesia patients and literature review. 61
31951917 2020
36
Structural and functional alterations of nitric oxide synthase 3 due to missense variants associate with high-altitude pulmonary edema through dynamic study. 61
31902292 2020
37
Effect of temperature variation on hospital admissions and outcomes in dogs with myxomatous mitral valve disease and new onset pulmonary edema. 61
31935277 2020
38
The evolution of radiographic edema in ARDS and its association with clinical outcomes: A prospective cohort study in adult patients. 61
32028223 2020
39
Determination of causes of death via spectrochemical analysis of forensic autopsies-based pulmonary edema fluid samples with deep learning algorithm. 61
31957147 2020
40
Serious Altitude Illness at the South Pole. 61
31852574 2020
41
BLOCKADE OF ENDOTHELIAL, BUT NOT EPITHELIAL, CELL EXPRESSION OF PD-L1 FOLLOWING SEVERE SHOCK ATTENUATES THE DEVELOPMENT OF INDIRECT ACUTE LUNG INJURY IN MICE. 61
31994912 2020
42
Protective effect of MOTS-c on acute lung injury induced by lipopolysaccharide in mice. 61
31931370 2020
43
Hemodynamic Monitoring in Patients With Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis. 61
32011413 2020
44
Low-tidal-volume prevent ventilation induced inflammation in a mouse model of sepsis. 61
31756342 2020
45
The hemodynamic effect of different left ventricular unloading techniques during veno-arterial extracorporeal life support: a systematic review and meta-analysis. 61
31948360 2020
46
Fluid intake-related association between urine output and mortality in acute respiratory distress syndrome. 61
31937303 2020
47
Genetic Predisposition to High-Altitude Pulmonary Edema. 61
31976756 2020
48
Impact of point-of-care ultrasound on the hospital length of stay for internal medicine inpatients with cardiopulmonary diagnosis at admission: study protocol of a randomized controlled trial-the IMFCU-1 (Internal Medicine Focused Clinical Ultrasound) study. 61
31915052 2020
49
Reverse Takotsubo Pattern in the Setting of Undiagnosed Pheochromocytoma and Pulmonary Embolism: A Rare Presentation. 61
31949122 2020
50
Transient Cerebral Ischemia at High Altitude and Hyper-Responsiveness to Hypoxia. 61
31971870 2020
Sources

Variations for Pulmonary Edema

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Expression for Pulmonary Edema

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Search GEO for disease gene expression data for Pulmonary Edema.
Sources

Pathways for Pulmonary Edema

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Pathways related to Pulmonary Edema according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Cytokine Signaling in Immune system 65
Show member pathways
 13.32 TNF IL1B IL10 ICAM1 HMOX1 FGF7
2
Immune response IL-23 signaling pathway 22
Show member pathways
 12.55 TNF NOS3 IL1B IL10 F2
3
Folate Metabolism 1
Show member pathways
 12.27 TNF IL1B ICAM1 F2 CRP
4
Pathogenic Escherichia coli infection 36
12.25 TNF IL1B F2 CXCL8
5
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.23 TNF IL1B IL10 FGF7 CXCL8
6
Dilated cardiomyopathy (DCM) 36
Show member pathways
 12.21 TNNI3 TNF EDN1 ACE
7
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.14 TNF IL1B IL10 CXCL8
8
IL-1 Family Signaling Pathways 64
Show member pathways
 12.14 TNF IL1B HMOX1 EDN1 CXCL8
9
Yersinia infection 36
11.99 TNF IL1B IL10 CXCL8
10
Spinal Cord Injury 1
11.98 TNF IL1B ICAM1 CXCL8
11
TNF signaling pathway 36
11.94 TNF IL1B ICAM1 EDN1
12
NF-kappa B signaling pathway 36
11.89 TNF IL1B ICAM1 CXCL8
13
Amoebiasis 36
11.88 TNF IL1B IL10 CXCL8
14
Rheumatoid arthritis 36
11.82 TNF IL1B ICAM1 CXCL8
15
Interleukin-4 and 13 signaling 65
11.79 TNF IL1B IL10 ICAM1 HMOX1 CXCL8
16
Innate Lymphoid Cell Differentiation Pathways 64
11.74 TNF IL1B IL10
17
Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics 60
Show member pathways
 11.74 REN NOS3 ACE
18
Pertussis 36
11.71 TNF IL1B IL10 CXCL8
19
Dendritic Cells Developmental Lineage Pathway 64
11.7 TNF IL1B IL10
20
Microglia Activation During Neuroinflammation: Microglia Polarization 64
11.68 TNF IL1B IL10
21
Renin secretion 36
11.66 REN EDN1 ACE
22
Fluid shear stress and atherosclerosis 36
11.64 TRPV4 TNF NOS3 IL1B ICAM1 HMOX1
23
AGE-RAGE signaling pathway in diabetic complications 36
11.63 TNF NOS3 IL1B ICAM1 EDN1 CXCL8
24
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.58 TNF IL1B ICAM1 CXCL8
25
Legionellosis 36
11.56 TNF IL1B CXCL8
26
Malaria 36
11.47 TNF IL1B IL10 ICAM1 CXCL8
27
Interleukin-10 signaling 65
11.41 TNF IL1B IL10 ICAM1 CXCL8
28
African trypanosomiasis 36
11.33 TNF IL1B IL10 ICAM1
29
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
11.32 NOS3 HMOX1 CXCL8
30
IL-10 Pathway 63
11.28 TNF IL1B IL10 HMOX1
31
Cytokines and Inflammatory Response 1
11.22 TNF IL1B IL10
32
IL1 and megakaryocytes in obesity 1
11.13 IL1B ICAM1 F2
33
Overview of nanoparticle effects 1
10.98 TNF HMOX1 CXCL8 CRP
34
Lung fibrosis 1
10.9 TNF IL1B HMOX1 FGF7 EDN1 CXCL8
35
LDL Oxidation in Atherogenesis 63
10.89 TNF IL1B ICAM1
Sources

GO Terms for Pulmonary Edema

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Cellular components related to Pulmonary Edema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 TNF SERPINC1 REN OXT NPPB IL1B
2 cell GO:0005623 9.76 TRPV4 TNNI3 OXT NOS3 ICAM1 HMOX1
3 extracellular space GO:0005615 9.47 TNF SERPINC1 REN OXT NPPB IL1B

Biological processes related to Pulmonary Edema according to GeneCards Suite gene sharing:

(show all 45)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.08 TRPV4 TNF NOS3 IL1B CRP
2 negative regulation of cell proliferation GO:0008285 10.08 NOS3 IL1B IL10 HMOX1 CXCL8
3 inflammatory response GO:0006954 10.04 TNF IL1B IL10 CXCL8 CRP
4 leukocyte migration GO:0050900 9.96 TNF IL1B ICAM1 F2
5 positive regulation of angiogenesis GO:0045766 9.91 NOS3 IL1B HMOX1 CXCL8
6 response to insulin GO:0032868 9.87 TRPV4 IL10 ICAM1
7 cellular response to drug GO:0035690 9.86 REN IL1B EDN1
8 response to glucocorticoid GO:0051384 9.85 TNF OXT IL10
9 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.83 TNF IL1B EDN1
10 positive regulation of smooth muscle cell proliferation GO:0048661 9.83 TNF HMOX1 EDN1
11 positive regulation of DNA-binding transcription factor activity GO:0051091 9.83 TNF IL1B IL10 EDN1
12 cellular response to lipopolysaccharide GO:0071222 9.83 TNF IL1B IL10 ICAM1 CXCL8
13 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.8 TNF IL10 EDN1
14 cytokine-mediated signaling pathway GO:0019221 9.8 TNF IL1B IL10 ICAM1 HMOX1 CXCL8
15 response to activity GO:0014823 9.78 OXT IL10 EDN1
16 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.77 NOS3 ICAM1 HMOX1
17 positive regulation of interleukin-6 secretion GO:2000778 9.76 TRPV4 TNF IL1B
18 lipopolysaccharide-mediated signaling pathway GO:0031663 9.75 TNF NOS3 IL1B
19 regulation of sensory perception of pain GO:0051930 9.72 OXT IL10 EDN1
20 positive regulation of JAK-STAT cascade GO:0046427 9.71 TNF IL10 F2
21 negative regulation of lipid storage GO:0010888 9.69 TNF CRP
22 negative regulation of platelet activation GO:0010544 9.69 NOS3 F2
23 body fluid secretion GO:0007589 9.69 NPPB EDN1
24 endothelial cell apoptotic process GO:0072577 9.67 TNF IL10
25 drinking behavior GO:0042756 9.67 REN OXT
26 acute inflammatory response to antigenic stimulus GO:0002438 9.67 SERPINC1 ICAM1
27 regulation of establishment of endothelial barrier GO:1903140 9.65 TNF IL1B
28 cellular hypotonic response GO:0071476 9.65 TRPV4 AQP5
29 regulation of blood vessel diameter GO:0097746 9.65 NPPB NOS3 ACE
30 hyperosmotic salinity response GO:0042538 9.64 TRPV4 OXT
31 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.63 NOS3 EDN1
32 negative regulation of cytokine secretion involved in immune response GO:0002740 9.63 TNF IL10
33 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.63 TNF IL1B IL10
34 positive regulation of fever generation GO:0031622 9.62 TNF IL1B
35 sequestering of triglyceride GO:0030730 9.6 TNF IL1B
36 positive regulation of renal sodium excretion GO:0035815 9.58 OXT NPPB EDN1
37 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.57 TNF IL1B
38 receptor biosynthetic process GO:0032800 9.56 TNF IL10
39 positive regulation of nitric oxide biosynthetic process GO:0045429 9.56 TNF IL1B ICAM1 EDN1
40 positive regulation of chemokine biosynthetic process GO:0045080 9.54 TNF IL1B HMOX1
41 negative regulation of gap junction assembly GO:1903597 9.51 IL1B ACE
42 smooth muscle hyperplasia GO:0014806 9.49 NOS3 HMOX1
43 response to lipopolysaccharide GO:0032496 9.43 REN NOS3 IL1B IL10 ICAM1 EDN1
44 positive regulation of prostaglandin secretion GO:0032308 9.33 OXT IL1B EDN1
45 regulation of blood pressure GO:0008217 9.1 REN NPPB NOS3 HMOX1 EDN1 ACE

Molecular functions related to Pulmonary Edema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 TNF IL1B IL10 EDN1 CXCL8
Sources

Sources for Pulmonary Edema

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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