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MCID: PLM010
MIFTS: 53

Pulmonary Edema

Categories: Respiratory diseases
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Aliases & Classifications for Pulmonary Edema

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MalaCards integrated aliases for Pulmonary Edema:

Name: Pulmonary Edema 11 43 14 16 71 75

Classifications:

MalaCards categories:
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)
ICD10: 31


External Ids:

Disease Ontology 11 DOID:11396
MeSH 43 D011654
NCIt 49 C26868
SNOMED-CT 68 19242006
ICD10 31 J81
UMLS 71 C0034063
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Summaries for Pulmonary Edema

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Disease Ontology: 11 A respiratory failure that is characterized by the accumulation of fluid in the lung tissues causing disturbance of the gas exchange that may lead to respiratory failure.

MalaCards based summary: Pulmonary Edema is related to adult respiratory distress syndrome and eclampsia, and has symptoms including hemoptysis, edema and peau d'orange. An important gene associated with Pulmonary Edema is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are MIF Mediated Glucocorticoid Regulation and TGF-Beta Pathway. The drugs Sodium citrate and Sildenafil have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and endothelial, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and homeostasis/metabolism

Wikipedia: 75 Pulmonary edema, also known as pulmonary congestion, is excessive liquid accumulation in the tissue and... more...
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Related Diseases for Pulmonary Edema

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Diseases related to Pulmonary Edema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1244)
# Related Disease Score Top Affiliating Genes
1 adult respiratory distress syndrome 32.9 TNF IL1B IL10 FGF7 CXCL8 CRP
2 eclampsia 32.1 TNF REN NOS3 F2 EDN1 ACE
3 hellp syndrome 32.0 IL10 F2 EDN1 CXCL8 CRP
4 silicosis 32.0 TNF IL1B IL10 CXCL8 ACE
5 renal artery atheroma 31.4 REN AGTR1 ACE
6 pulmonary hypertension 31.4 TNF REN NPPB NOS3 EDN1 CRP
7 mitral valve stenosis 31.3 REN NPPB F2 EDN1 CRP ACE
8 mitral valve insufficiency 31.3 TNNI3 REN NPPB F2 CRP ACE
9 pulmonary embolism 31.2 TNNI3 NPPB F2 CRP ACE
10 cardiac arrest 31.1 TNNI3 NPPB CRP ACE
11 diabetes mellitus, ketosis-prone 31.1 REN CRP ACE
12 plasmodium falciparum malaria 31.1 TNF IL10 ICAM1
13 heart septal defect 31.1 NPPB F2 CRP
14 aspiration pneumonitis 31.0 TNF CXCL8 CRP
15 pheochromocytoma 31.0 TNF REN KNG1 IL1B EDN1 CRP
16 acute kidney failure 31.0 REN KNG1 F2 ACE
17 congestive heart failure 31.0 TNNI3 TNF REN NPPB KNG1 IL1B
18 spontaneous tension pneumothorax 31.0 NPPB CRP
19 disseminated intravascular coagulation 30.9 TNF IL10 F2 CRP
20 mouth disease 30.9 NPPB IL13 IL10 CRP
21 infective endocarditis 30.9 NPPB F2 CXCL8 CRP ACE
22 encephalitis 30.9 TNF IL1B IL10 CXCL8
23 orthostatic intolerance 30.9 REN NOS3 CRP AGTR1 ACE
24 mediastinitis 30.8 F2 CRP ACE
25 intracranial hypertension 30.8 TNF REN NPPB IL1B F2 CRP
26 toxic shock syndrome 30.8 TNF IL1B IL10 CXCL8 CSF3 CRP
27 pulmonary disease, chronic obstructive 30.8 TNF NPPB IL1B IL13 CXCL8 CRP
28 cardiac tamponade 30.8 TNNI3 REN NPPB F2 CRP ACE
29 hyperthyroidism 30.8 TNF REN F2 CRP
30 rheumatic heart disease 30.8 TNF NPPB IL1B IL10 ACE
31 aortic valve disease 2 30.8 TNNI3 REN NPPB CRP ACE
32 pancreatitis 30.8 TNF IL1B IL10 CXCL8 CRP
33 aspiration pneumonia 30.7 TNF IL1B F2 CXCL8 CRP ACE
34 rheumatic fever 30.7 TNF NPPB IL10 ICAM1 ACE
35 pneumonia 30.7 TNF IL1B IL13 IL10 CXCL8 CSF3
36 hemopneumothorax 30.7 F2 CRP
37 mitral valve disease 30.7 TNNI3 REN NPPB F2 EDN1 CRP
38 heart valve disease 30.7 TNNI3 REN NPPB F2 EDN1 CRP
39 aortic valve insufficiency 30.7 TNNI3 REN NPPB F2 CRP ACE
40 vascular disease 30.7 TNF NOS3 KNG1 ICAM1 F2 EDN1
41 aortic dissection 30.7 TNF NOS3 CRP ACE
42 poliomyelitis 30.7 TNF IL10 ICAM1
43 pulmonary fibrosis 30.7 IL1B IL13 FGF7 EDN1 CXCL8
44 bronchopneumonia 30.6 TNF IL1B IL10 CXCL8 CRP
45 pre-eclampsia 30.6 TNF REN NOS3 KNG1 IL1B IL10
46 diaphragmatic hernia, congenital 30.6 NOS3 FGF7 EDN1 CRP
47 acute pancreatitis 30.6 TNF IL1B IL10 ICAM1 CXCL8 CRP
48 atrioventricular block 30.6 TNNI3 NPPB CRP ACE
49 lung disease 30.6 TNF NPPB IL1B IL13 IL10 ICAM1
50 glomerulonephritis 30.6 TNF REN IL1B IL10 ICAM1 CRP

Graphical network of the top 20 diseases related to Pulmonary Edema:



Diseases related to Pulmonary Edema
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Symptoms & Phenotypes for Pulmonary Edema

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UMLS symptoms related to Pulmonary Edema:


hemoptysis; edema; peau d'orange

GenomeRNAi Phenotypes related to Pulmonary Edema according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.18 ACE AGTR1 AQP5 CRP CSF3 CXCL8
2 no effect GR00402-S-2 10.18 ACE AGTR1 CRP CSF3 EDN1 F2
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 10.07 CXCL8 IL10 IL1B REN TNF
4 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 10.07 ACE CXCL8 ICAM1 IL10 IL1B REN
5 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 10.07 ICAM1

MGI Mouse Phenotypes related to Pulmonary Edema:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.22 ACE AGTR1 AQP5 CRP EDN1 F2
2 nervous system MP:0003631 10.18 AGTR1 EDN1 F2 FGF7 ICAM1 IL10
3 muscle MP:0005369 10.15 AQP5 EDN1 F2 ICAM1 IL10 IL13
4 cardiovascular system MP:0005385 10 ACE AGTR1 CRP EDN1 F2 ICAM1
5 digestive/alimentary MP:0005381 9.86 AQP5 EDN1 F2 ICAM1 IL10 IL13
6 immune system MP:0005387 9.77 ACE AGTR1 CRP CSF3 F2 FGF7
7 respiratory system MP:0005388 9.23 AQP5 F2 IL10 IL13 NOS3 TNF
Sources

Drugs & Therapeutics for Pulmonary Edema

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Drugs for Pulmonary Edema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 77)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sodium citrate Approved, Investigational Phase 4 68-04-2 23431961
2
Sildenafil Approved, Investigational Phase 4 139755-83-2, 171599-83-0 5212 135398744
3
Dobutamine Approved Phase 4 34368-04-2 36811
4
Milrinone Approved Phase 4 78415-72-2 4197
5
Isosorbide dinitrate Approved, Investigational Phase 4 87-33-2 3780 6883
6
Isosorbide Approved, Investigational Phase 4 652-67-5 99937 12597
7
Nitric Oxide Approved Phase 4 10102-43-9 145068
8
Acetazolamide Approved, Vet_approved Phase 4 59-66-5, 1424-27-7 1986
9
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
10
Morphine Approved, Investigational Phase 4 57-27-2 5288826
11
Citric acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
12 Phosphodiesterase Inhibitors Phase 4
13 Phosphodiesterase 5 Inhibitors Phase 4
14 Citrate Phase 4
15 Cardiotonic Agents Phase 4
16 Adrenergic beta-Agonists Phase 4
17 Adrenergic Agonists Phase 4
18 Adrenergic Agents Phase 4
19 Phosphodiesterase 3 Inhibitors Phase 4
20 Platelet Aggregation Inhibitors Phase 4
21 Sympathomimetics Phase 4
22 Protective Agents Phase 4
23 Isosorbide-5-mononitrate Phase 4
24 diuretics Phase 4
25 Carbonic Anhydrase Inhibitors Phase 4
26 Anticonvulsants Phase 4
27 Analgesics Phase 4
28 Neurotransmitter Agents Phase 4
29 Anti-Anxiety Agents Phase 4
30 Psychotropic Drugs Phase 4
31 Anesthetics, Intravenous Phase 4
32 Anesthetics, General Phase 4
33 Anesthetics Phase 4
34 Hypnotics and Sedatives Phase 4
35 GABA Modulators Phase 4
36 Analgesics, Opioid Phase 4
37 Narcotics Phase 4
38
Magnesium sulfate Approved, Investigational, Vet_approved Phase 3 7487-88-9
39 Hormones Phase 3
40 Calcium, Dietary Phase 3
41 calcium channel blockers Phase 3
42 Tocolytic Agents Phase 3
43 Anti-Arrhythmia Agents Phase 3
44
Calcium Nutraceutical Phase 3 7440-70-2 271
45
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1, Phase 2 1177-87-3 3680
46
Dexamethasone Approved, Investigational, Vet_approved Phase 1, Phase 2 50-02-2 3003 5743
47
Tadalafil Approved, Investigational Phase 1, Phase 2 171596-29-5 110635
48
Salbutamol Approved, Vet_approved Phase 2 18559-94-9 2083
49
Glycerin Approved, Investigational Phase 2 56-81-5 753
50
Furosemide Approved, Vet_approved Phase 2 54-31-9 3440

Interventional clinical trials:

(show top 50) (show all 122)
# Name Status NCT ID Phase Drugs
1 Impact of Fluid Resuscitation Therapy on Pulmonary Edema as Measured by Alveolar Fluid Clearance in Patients With Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT01763853 Phase 4 4% albumin
2 Non-Invasive Positive Pressure Mask Ventilation vs Extrathoracic Biphasic Cuirass Ventilation in Patients With Acute Respiratory Failure: A Randomized Prospective Study. Unknown status NCT00331656 Phase 4
3 Non Invasive Positive Airway Pressure And Risk Of Myocardial Infarction In Acute Cardiogenic Pulmonary Edema: Continuous Positive Airway Pressure Vs Non Invasive Positive Pressure Ventilation Completed NCT00453947 Phase 4
4 Randomised Controlled Comparison of Continuous Positive Airway Pressure (CPAP) With Standard Treatment in Out-of-hospital Patients With Acute Cardiogenic Pulmonary Edema. Completed NCT00439075 Phase 4 standard treatment
5 CPAP Versus BiPAP in Acute Cardiogenic Pulmonary Edema: Experience With 129 Patients Completed NCT00912158 Phase 4
6 Continuous Positive Airway Pressure Versus Non-Invasive Positive Pressure Support Ventilation in Acute Cardiogenic Pulmonary Oedema: a Prospective Randomised Multicentre Trial. Completed NCT00446498 Phase 4
7 Comparison of Milrinone Versus Dobutamine in a Heterogeneous Population of Critically Ill Patients Completed NCT03207165 Phase 4 Milrinone;Dobutamine
8 Randomized, Controlled Trial of Regular Sildenafil Citrate in the Prevention of Altitude Illness Completed NCT00627965 Phase 4 Sildenafil citrate;Placebo
9 Impact of Obstructive Sleep Apnea Treatment on Cardiovascular Events in Patients With Acute Cardiogenic Pulmonary Edema: a Multicenter Randomized Controlled Study (CPAP-CARE STUDY). Recruiting NCT03936751 Phase 4
10 Vasodilation or Loop-diuretics for Initial Treatment of Pulmonary Edema or Congestion Due to Acute Heart Failure - a Randomized Placebo-controlled Trial Not yet recruiting NCT05276219 Phase 4 Furosemide Injection;Isosorbide Dinitrate;Furosemide and isosorbide dinitrate
11 A Prospective, Double-blind, Randomized, Placebo-controlled Trial of Acetazolamide on Subclinical High-Altitude Pulmonary Edema Detected by Lung Ultrasonography Terminated NCT03490916 Phase 4 Acetazolamide;Placebo
12 Study Design and Rationale of "A Multicenter, Open-Labeled, Randomized Controlled Trial Comparing MIdazolam Versus MOrphine in Acute Pulmonary Edema": MIMO Trial Terminated NCT02856698 Phase 4 Midazolam;Morphine
13 Double Blind Randomized Placebo Controlled Trial of Natrecor in Patients Hospitalized for Decompensated Heart Failure in the Presence of a Normal Left Ventricular Ejection Fraction Withdrawn NCT00505791 Phase 4 Nesiritide
14 Non-Invasive Ventilation Versus Continuous Positive Airway Pressure in Cardiogenic Pulmonary Edema: a Multicentre Study Completed NCT00785174 Phase 3
15 Effect of Continuous Positive Airway Pressure as a First Line Therapy in Out-of-Hospital Management of Severe Cardiogenic Pulmonary Edema Completed NCT00390442 Phase 3
16 Effect of Continuous Positive Airway Pressure on Short Term Inhospital Prognosis for Acute Pulmonary Edema Completed NCT00554580 Phase 3
17 CPAP Boussignac Versus Bilevel Pressure Support Ventilation in Severe Acute Cardiogenic Pulmonary Edema Completed NCT00213681 Phase 3
18 Randomized Clinical Trial of the Beneficial Effects of Antenatal Magnesium Sulfate (BEAM) Completed NCT00014989 Phase 3 magnesium sulfate
19 A Randomized Controlled Trial of the Effects of Tadalafil and Dexamethasone Versus Placebo on Pulmonary Edema Formation and Cerebral Blood Flow Autoregulation in High Altitude Newcomers With a Previous History of High Altitude Pulmonary Edema Completed NCT00274430 Phase 1, Phase 2 dexamethasone 8 mg bid;tadalafil 10mg bid
20 Sildenafil for Prevention of Swimming-Induced Pulmonary Edema (SIPE) Completed NCT03686813 Phase 2 Sildenafil Citrate;Placebo Oral Tablet
21 The Evaluation of the Effect of Sodium Bicarbonate Solution in Decreasing the Incidence of Contrast Induced Nephropathy (CIN) in Patients With Pulmonary Edema,Severe Heart Failure or Uncontrolled Hypertension Completed NCT00513825 Phase 2 Sodium Bicarbonate
22 A Pilot Study Of ALT-711 In Elderly Patients With Isolated Diastolic Heart Failure: The DIAMOND Study Completed NCT00043836 Phase 2 ALT-711
23 The Effect of Nebulized Albuterol on Donor Oxygenation Completed NCT00310401 Phase 2 Albuterol;Saline
24 B-lines Lung Ultrasound Guided ED Management of Acute Heart Failure Pilot Trial Completed NCT03136198 Phase 2 Intravenous Loop Diuretic;Vasodilator
25 A Sponsor Un-blinded, Placebo-controlled Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single and Repeat, Ascending Doses of GSK2798745 in Healthy Subjects and Stable Heart Failure Patients Completed NCT02119260 Phase 2 GSK2798745 solution;GSK2798745 suspension;GSK2798745 capsule;Placebo solution;Placebo suspension;Placebo capsule
26 Phase II Randomized, Intervention Versus Non-Intervention, Multi-center Study of the Effects of Thyroid Hormone (T3) on Extravascular Lung Water (EVLW) in Subjects With Acute Respiratory Distress Syndrome (ARDS) Recruiting NCT04115514 Phase 1, Phase 2 Liothyronine Sodium (T3) (modified formulation)
27 A Randomised, Double-blind, Placebo-controlled Study to Investigate the Safety and Efficacy of Intravenous Imatinib Mesylate (Impentri®) in Subjects With Acute Respiratory Distress Syndrome Induced by COVID-19 Recruiting NCT04794088 Phase 2 Imatinib Mesylate intravenous solution;Placebo
28 A Randomized, Double-Blind, Parallel Group Study to Assess the Efficacy and Safety of Once Weekly Subcutaneous Injections of Pemziviptadil (PB1046), a Sustained-Release VIP (Vasoactive Intestinal Peptide) ANalogue, in Hospitalized COVID-19 Patients at HiGh Risk for Rapid Clinical Deterioration and ARDS (PB1046 VANGARD Study) Terminated NCT04433546 Phase 2 Pemziviptadil (PB1046);Low Dose (10 mg) Control
29 Nitroglycerin vs. Furosemide Using Lung Ultrasound Pilot Trial (N-FURIOUS) Terminated NCT03259165 Phase 2 Nitrates;Loop Diuretics
30 A Randomized, Double-blind, Multicentre 2-arm, Parallel-group, Placebo-controlled Study to Investigate the Efficacy and Safety of Intravenous Imatinib Mesylate in Reducing the Severity of Hypoxemic Respiratory Failure in Patients With Critical COVID-19 Receiving Standard of Care. Withdrawn NCT04953052 Phase 2 Imatinib Mesylate;Placebo
31 Hypoxia Impairs Systemic Endothelial Function in Individuals Prone to High-Altitude Pulmonary Edema. Completed NCT00176007 Phase 1
32 An Evaluation of DCE-MRI Measures of Pulmonary Oedema and Vascular Permeability in Healthy Subjects and in Patients With Cardiac Failure: A Methods Validation Study for Evaluation of Novel Treatments Limiting Pulmonary Oedema in Cardiac Failure Completed NCT02135861 Phase 1
33 An Evaluation of MRI Measures of Lung Water Increases With Postural Changes in Healthy Subjects and in Patients With Cardiac Failure: A Methods Validation Study for Evaluation of Novel Treatments Limiting Pulmonary Oedema in Cardiac Failure Completed NCT01277679 Phase 1
34 Inhaled Hypertonic Saline for the Treatment of Acute Lung Injury Withdrawn NCT01713595 Phase 1 Hypertonic Saline Aerosol
35 Power Spectral Analysis of Lung Sounds Detected at Bilateral Lung Bases in Patients With Cardiogenic and Non-cardiogenic Pulmonary Edema Unknown status NCT00767195
36 Non-Invasive Positive Pressure Ventilation Management of High Altitude Pulmonary Edema Unknown status NCT04288219 Nifedipine
37 The Role of Lung Ultrasound in The Diagnosis of Weaning -Induced Pulmonary Edema Unknown status NCT04463303
38 Mortality and Risk Factors in Patients With Acute Cardiogenic Pulmonary Edema: a Multicentric, Observational, Prospective Study Unknown status NCT01269177
39 High Flow Nasal Oxygen Versus VNI for Emergency Department Treatment of Acute Hypercapnic Cardiogenic Pulmonary Edema With Respiratory Failure: a Multicenter Randomized Non Inferiority Trial Unknown status NCT02874339
40 Electrical Impedance Tomography for Quantification of Pulmonary Edema in Acute Respiratory Distress Syndrome Patients Unknown status NCT02870894
41 Collection of Whole Blood Samples for the Evaluation of Preeclampsia (Pre-E) Biomarkers Unknown status NCT03767803
42 Training Thoracic Ultrasound Skills: a Multicentre, Blinded, Randomized Controlled Trial of Simulation-based Training Versus Training on Healthy Figurants Unknown status NCT03728491
43 Registry Of Acute meDical Emergencies in Brazil - ROAD-Brazil Unknown status NCT02753023
44 Hemodynamic Changes in Altitude Adaptation Unknown status NCT01698619
45 Non-Invasive Pulmonary Monitoring in Patients With Cardiogenic Pulmonary Congestion and Edema Unknown status NCT01885403
46 Evaluation of the Effectiveness of Non-invasive Ventilation on the Reperfusion Pulmonary Oedema Post Pulmonary Artery Angioplasty in the Post Embolic Pulmonary Hypertension Unknown status NCT02548091
47 Intra-operative Inspiratory Oxygen Fraction and Postoperative Respiratory Complications Unknown status NCT02399878 Inspiratory oxygen
48 The Incidence of Transfusion-Related Acute Lung Injury (TRALI) Following Blood Product Transfusion in Patients Undergoing Elective Orthopedic-Oncology Procedures Unknown status NCT00914784
49 The Practice of Fluid Management in the Post-anesthetic Care Unit (PACU) in Patients Undergoing Elective Surgery: an Observational Study Unknown status NCT00995228
50 Intolerance Mechanisms and Exercise Performance Limitation During a High Altitude Stay: Investigation of Sleep and Cerebral Responses Unknown status NCT01565603

Search NIH Clinical Center for Pulmonary Edema

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Bumetanide
Ethacrynate Sodium
Ethacrynic Acid
Furosemide
Mannitol hexanitrate
torsemide

Cochrane evidence based reviews: pulmonary edema

Sources

Genetic Tests for Pulmonary Edema

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Anatomical Context for Pulmonary Edema

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Organs/tissues related to Pulmonary Edema:

MalaCards : Lung, Heart, Endothelial, Bone Marrow, Liver, Placenta, Neutrophil
Sources

Publications for Pulmonary Edema

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Articles related to Pulmonary Edema:

(show top 50) (show all 15989)
# Title Authors PMID Year
1
Cardiovascular Complications During Delivery Admissions Associated With Assisted Reproductive Technology (from a National Inpatient Sample Analysis 2008 to 2019). 62
36283885 2023
2
Insulin edema: An untypical etiology of anasarca in a 19-year old female presenting to a pediatric emergency department. 62
36266213 2023
3
High-dose nitroglycerin infusion description of safety and efficacy in sympathetic crashing acute pulmonary edema: The HI-DOSE SCAPE study. 62
36327753 2023
4
Iso-seco-tanapartholide from Artemisia argyi inhibits the PFKFB3-mediated glycolytic pathway to attenuate airway inflammation in lipopolysaccharide-induced acute lung injury mice. 62
36195302 2023
5
23-O-acetylshengmanol-3-O-α-L-arabinoside alleviates lipopolysaccharide-induced acute lung injury through inhibiting IκB/NF-κB and MAPK/AP-1 signaling pathways. 62
36115602 2023
6
Genetics of High-Altitude Pulmonary Edema. 62
36435576 2023
7
Can albumin reduce the mortality of patients with cirrhosis and ascites? A meta-analysis of randomized controlled trials. 62
36165067 2023
8
AGA Clinical Practice Update on the Evaluation and Management of Acute Kidney Injury in Patients With Cirrhosis: Expert Review. 62
36075500 2022
9
CD14 signaling mediates lung immunopathology and mice mortality induced by Achromobacter xylosoxidans. 62
36280620 2022
10
Buttons and Zippers: Endothelial Junctions in Lymphatic Vessels. 62
35534209 2022
11
Responses to Ang II (Angiotensin II), Salt Intake, and Lipopolysaccharide Reveal the Diverse Actions of TNF-α (Tumor Necrosis Factor-α) on Blood Pressure and Renal Function. 62
36129177 2022
12
Mean corpuscular haemoglobin concentration (MCHC): a new biomarker for high-altitude pulmonary edema in the Ecuadorian Andes. 62
36456626 2022
13
Lung ultrasound assessment of pulmonary edema in neonates with chronic lung disease before and after diuretic therapy. 62
36174499 2022
14
Pulmonary edema in a pediatric cancer patient after anesthetic induction. 62
35999184 2022
15
An unusual cause of pulmonary infiltrates mimicking pulmonary edema: metastatic calcifications. 62
36204407 2022
16
Eleutheroside B ameliorated high altitude pulmonary edema by attenuating ferroptosis and necroptosis through Nrf2-antioxidant response signaling. 62
36411652 2022
17
Negative pressure pulmonary edema in a patient with COVID-19. 62
36320444 2022
18
Inhibition of inflammasome activation via sphingolipid pathway in acute lung injury by Huanglian Jiedu decoction: An integrative pharmacology approach. 62
36202056 2022
19
Vitamin-D ameliorates sepsis-induced acute lung injury via augmenting miR-149-5p and downregulating ER stress. 62
35988833 2022
20
Dexmedetomidine attenuates subarachnoid hemorrhage-induced acute lung injury through regulating autophagy and TLR/NFκB signaling pathway. 62
35912428 2022
21
Total terpenoids of Inula japonica activated the Nrf2 receptor to alleviate the inflammation and oxidative stress in LPS-induced acute lung injury. 62
36116200 2022
22
Rhein ameliorates septic lung injury and intervenes in macrophage metabolic reprogramming in the inflammatory state by Sirtuin 1. 62
36279970 2022
23
Total flavonoids of Inula japonica alleviated the inflammatory response and oxidative stress in LPS-induced acute lung injury via inhibiting the sEH activity: Insights from lipid metabolomics. 62
36150346 2022
24
Delivery risks and outcomes associated with grand multiparity. 62
34470116 2022
25
Lacticaseibacillus rhamnosus attenuates acute lung inflammation in a murine model of acute respiratory distress syndrome: Relevance to cytokines associated to STAT4/T-bet and STAT3/RORÉ£t". 62
36280164 2022
26
Computational pulmonary edema: A microvascular model of alveolar capillary and interstitial flow. 62
36389648 2022
27
Diabetes and Excess Aldosterone Promote Heart Failure With Preserved Ejection Fraction. 62
36416174 2022
28
Left Atrial Decompression in Pediatric Patients Supported With Extracorporeal Membrane Oxygenation for Failure to Wean From Cardiopulmonary Bypass: A Propensity-Weighted Analysis. 62
35535596 2022
29
Engraftment syndrome following Hematopoietic stem cell transplantation: a systematic approach toward diagnosis and management. 62
36460884 2022
30
Medical students' and health professionals' knowledge regarding acute kidney injury: a cross-sectional study in the city of São Paulo, Brazil. 62
36326657 2022
31
Transcatheter Valve Implantation in Reversed Potts Shunt in Pulmonary Arterial Hypertension: Keeping the Shunt Reversed. 62
36458180 2022
32
Cardiac and obstetric outcomes in pregnant patients with heart disease: a retrospective cohort study. 62
33632045 2022
33
The role of furosemide and fluid management for a hemodynamically significant patent ductus arteriosus in premature infants. 62
35840707 2022
34
Sleep disordered breathing and the risk of severe maternal morbidity in women with preeclampsia: A population-based study. 62
36343510 2022
35
The Dropsy of Popes (1555-1978): A Bad Prognostic Sign Foreboding of Death. 62
35596044 2022
36
Absent Pulmonary Artery Presenting as High-Altitude Pulmonary Edema. 62
36427025 2022
37
Extraction and Quantification of Words Representing Degrees of Diseases: Combining the Fuzzy C-Means Method and Gaussian Membership. 62
36399376 2022
38
Peripheral Edema: Evaluation and Management in Primary Care. 62
36379502 2022
39
Analysis of Cardiovascular Complications During Delivery Admissions Among Patients With Systemic Lupus Erythematosus, 2004-2019. 62
36445710 2022
40
Experience with remote dielectric sensing (ReDS) for acute decompensated heart failure complicated by chronic obstructive pulmonary disease. 62
36312776 2022
41
Retrospective evaluation of clinical signs, clinical course, and prognosis between dogs with left atrial rupture secondary to myxomatous mitral valve disease and those with neoplastic cardiac tamponade (2015-2019): 70 cases. 62
35960167 2022
42
A typical case had rare immediate and delayed red man syndrome multiple times after norvancomycin injection: A case report. 62
36451439 2022
43
Scutellaria baicalensis Pith-decayed Root Inhibits Macrophage-related Inflammation Through the NF-κB/NLRP3 Pathway to Alleviate LPS-induced Acute Lung Injury. 62
35716667 2022
44
Host transcriptomic profiling of CD-1 outbred mice with severe clinical outcomes following infection with Orientia tsutsugamushi. 62
36417363 2022
45
Histopathological pulmonary findings of survivors and autopsy COVID-19 cases: A bi-center study. 62
36451501 2022
46
Liver Transplant Outcomes in Patients With Postcapillary Pulmonary Hypertension. 62
36245997 2022
47
Acquired Systolic Dysfunction and Subsequent Congestive Heart Failure Following Treatment of Hypoadrenocorticism in Two Dogs. 62
36315864 2022
48
A 56-Year-Old Man with Mitral Regurgitation and Acute Pulmonary Edema: Rupture of the Papillary Muscle or Infective Endocarditis? 62
36451867 2022
49
Prolonged labor and adverse cardiac outcomes in pregnant patients with congenital heart disease. 62
36427597 2022
50
A novel 12-hour versus 24-hour magnesium sulfate regimen in the management of eclampsia and preeclampsia in Ghana (MOPEP Study): A randomized controlled trial. 62
35304745 2022
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Variations for Pulmonary Edema

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Expression for Pulmonary Edema

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Search GEO for disease gene expression data for Pulmonary Edema.
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Pathways for Pulmonary Edema

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Pathways related to Pulmonary Edema according to GeneCards Suite gene sharing:

(show all 39)
# Super pathways Score Top Affiliating Genes
1
MIF Mediated Glucocorticoid Regulation 64
Show member pathways
 13.6 CSF3 CXCL8 EDN1 F2 IL10 IL13
2
TGF-Beta Pathway 64
Show member pathways
 13.49 TNF IL1B IL13 IL10 ICAM1 FGF7
3
Akt Signaling 64
Show member pathways
 13.38 TNF NOS3 IL1B IL13 IL10 FGF7
4
Cytokine Signaling in Immune system 66
Show member pathways
 13.28 CSF3 CXCL8 ICAM1 IL10 IL13 IL1B
5
PAK Pathway 64
Show member pathways
 13.26 TNF IL1B IL13 IL10 FGF7 CXCL8
6
Overview of interferons-mediated signaling pathway 74
Show member pathways
 12.54 TNF IL1B IL13 IL10 FGF7 CXCL8
7
Immune response IL-23 signaling pathway 22
Show member pathways
 12.52 AGTR1 F2 IL10 IL1B NOS3 TNF
8
Neuroinflammation and glutamatergic signaling 74
12.08 TNF IL1B IL13 IL10
9
Sudden infant death syndrome (SIDS) susceptibility pathways 74
12.08 TNF IL1B IL13 IL10 CXCL8
10
Spinal cord injury 74
11.97 TNF IL1B ICAM1 CXCL8
11
ACE Inhibitor Pathway, Pharmacodynamics 60
Show member pathways
 11.9 TNF REN NOS3 KNG1 AGTR1 ACE
12
Interleukin-4 and Interleukin-13 signaling 66
11.83 TNF IL1B IL13 IL10 ICAM1 CXCL8
13
Innate Lymphoid Cells Differentiation 65
11.77 TNF IL1B IL13 IL10
14
Glucocorticoid receptor regulatory network 61
11.74 IL13 ICAM1 CXCL8
15
Burn wound healing 74
11.73 TNF IL1B ICAM1 CXCL8
16
Dendritic Cells Developmental Lineage Pathway 65
11.72 TNF IL1B IL10
17
Extrafollicular B cell activation by SARS-CoV-2 74
11.7 TNF IL10 CRP
18
Allograft rejection 74
11.7 AGTR1 CXCL8 IL10 IL13 IL1B TNF
19
AP-1 transcription factor network 61
11.68 IL10 EDN1 CXCL8
20
Photodynamic therapy-induced NF-kB survival signaling 74
Show member pathways
 11.64 TNF IL1B ICAM1 CXCL8
21
IL 10 signaling pathway 67
11.63 TNF IL1B IL10
22
miRNAs involvement in the immune response in sepsis 74
11.62 TNF IL10 ICAM1 CXCL8
23
Inflammatory bowel disease signaling 74
Show member pathways
 11.6 TNF IL13 IL10
24
Netrin-UNC5B signaling pathway 74
11.54 TNF IL10 ICAM1
25
SARS-CoV-2 innate immunity evasion and cell-specific immune response 74
11.53 TNF IL10 CXCL8
26
IL-10 Pathway 64
11.34 TNF IL1B IL10
27
Development and heterogeneity of the ILC family 74
11.3 TNF IL1B IL13
28
Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway 74
11.26 CXCL8 IL1B TNF
29
Prostaglandin signaling 74
11.21 TNF IL1B CXCL8
30
IL1 and megakaryocytes in obesity 74
11.14 IL1B ICAM1 F2
31
Immune infiltration in pancreatic cancer 74
11.14 TNF IL13 IL10 CXCL8
32
Interleukin-10 signaling 66
11.1 TNF IL1B IL10 ICAM1 CXCL8 CSF3
33
Overview of nanoparticle effects 74
11.03 CRP CXCL8 TNF
34
Cytokines and inflammatory response 74
11.02 TNF IL1B IL13 IL10 CSF3
35
Lung fibrosis 74
10.97 TNF IL1B IL13 FGF7 EDN1 CXCL8
36
LDL Oxidation in Atherogenesis 64
10.93 TNF IL1B ICAM1
37
G-protein signaling_Rap2B regulation pathway 22
10.9 CSF3 CXCL8 FGF7 IL10 IL13 IL1B
38
IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types 65
10.76 IL1B IL13
39
Cells and molecules involved in local acute inflammatory response 74
Show member pathways
 10.31 TNF KNG1 CXCL8
Sources

GO Terms for Pulmonary Edema

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Cellular components related to Pulmonary Edema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.1 ACE CRP CSF3 CXCL8 EDN1 F2
2 extracellular space GO:0005615 9.8 ACE CRP CSF3 CXCL8 EDN1 F2

Biological processes related to Pulmonary Edema according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 10.28 TNF IL1B IL13 IL10 CXCL8 CSF3
2 inflammatory response GO:0006954 10.28 AGTR1 CRP CXCL8 IL13 IL1B KNG1
3 response to xenobiotic stimulus GO:0009410 10.21 ACE EDN1 IL10 REN TNF
4 cellular response to lipopolysaccharide GO:0071222 10.16 CSF3 CXCL8 IL10 IL1B TNF
5 calcium-mediated signaling GO:0019722 10.15 TNF EDN1 CXCL8 AGTR1
6 positive regulation of gene expression GO:0010628 10.13 TRPV4 TNF NOS3 IL1B IL13 FGF7
7 positive regulation of vascular associated smooth muscle cell proliferation GO:1904707 10.12 TNF IL10 EDN1
8 positive regulation of nitric oxide biosynthetic process GO:0045429 10.11 EDN1 IL1B TNF
9 positive regulation of DNA-binding transcription factor activity GO:0051091 10.1 TNF IL1B IL10 EDN1 CSF3
10 lipopolysaccharide-mediated signaling pathway GO:0031663 10.09 TNF NOS3 IL1B
11 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 10.08 TNF IL10 F2
12 negative regulation of endothelial cell apoptotic process GO:2000352 10.07 IL13 IL10 ICAM1
13 positive regulation of inflammatory response GO:0050729 10.07 ACE AGTR1 IL1B TNF TRPV4
14 positive regulation of mitotic nuclear division GO:0045840 10.05 EDN1 IL1B TNF
15 regulation of vasoconstriction GO:0019229 9.97 EDN1 AGTR1 ACE
16 body fluid secretion GO:0007589 9.96 NPPB EDN1
17 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.95 NOS3 EDN1
18 vasoconstriction GO:0042310 9.95 EDN1 CRP ACE
19 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.94 AGTR1 ACE
20 negative regulation of cytokine production involved in immune response GO:0002719 9.94 TNF IL10
21 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.93 TNF IL1B IL10
22 positive regulation of fever generation GO:0031622 9.92 TNF IL1B
23 vasodilation GO:0042311 9.92 TNF NPPB NOS3 KNG1
24 sequestering of triglyceride GO:0030730 9.9 TNF IL1B
25 leukocyte migration GO:0050900 9.88 TNF IL1B ICAM1
26 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.87 TNF IL1B
27 renin-angiotensin regulation of aldosterone production GO:0002018 9.86 REN AGTR1
28 negative regulation of gap junction assembly GO:1903597 9.84 IL1B ACE
29 chronic inflammatory response to antigenic stimulus GO:0002439 9.83 TNF IL10
30 regulation of blood pressure GO:0008217 9.81 ACE EDN1 NOS3 NPPB REN
31 response to lipopolysaccharide GO:0032496 9.8 TNF REN NOS3 IL1B IL13 IL10
32 blood vessel diameter maintenance GO:0097746 9.32 NPPB NOS3 KNG1 EDN1 AGTR1 ACE

Molecular functions related to Pulmonary Edema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.7 TNF REN NPPB KNG1 F2 EDN1
2 bradykinin receptor binding GO:0031711 9.46 AGTR1 ACE
3 cytokine activity GO:0005125 9.44 TNF IL1B IL13 IL10 EDN1 CXCL8
Sources

Sources for Pulmonary Edema

About this section
2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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