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MCID: PLM010
MIFTS: 58

Pulmonary Edema

Categories: Cardiovascular diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Pulmonary Edema

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MalaCards integrated aliases for Pulmonary Edema:

Name: Pulmonary Edema 12 44 15 73

Classifications:

MalaCards categories:
Anatomical: Respiratory diseases Cardiovascular diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:11396
ICD10 33 J81 J81.1
MeSH 44 D011654
NCIt 50 C26868
SNOMED-CT 68 19242006
UMLS 73 C0034063
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Summaries for Pulmonary Edema

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MalaCards based summary : Pulmonary Edema is related to acute mountain sickness and acute respiratory distress syndrome, and has symptoms including edema, hemoptysis and peau d'orange. An important gene associated with Pulmonary Edema is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Immune response IL-23 signaling pathway. The drugs Midazolam and Morphine have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and kidney, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 76 Pulmonary edema is fluid accumulation in the tissue and air spaces of the lungs. It leads to impaired... more...

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Related Diseases for Pulmonary Edema

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Diseases related to Pulmonary Edema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 487)
# Related Disease Score Top Affiliating Genes
1 acute mountain sickness 33.3 ACE EDN1 NOS3 PIK3C2A
2 acute respiratory distress syndrome 32.9 CXCL8 IL1B TNF
3 adult respiratory distress syndrome 32.9 ACE CXCL8 F2 IL10 TNF
4 chronic mountain sickness 32.3 EDN1 NOS3 NPPB
5 myocarditis 30.3 ICAM1 NPPB TNF
6 ischemia 30.2 ACE EDN1 HMOX1 ICAM1 NOS3
7 eclampsia 30.0 EDN1 F2 REN TNF
8 respiratory failure 30.0 ACE CRP CXCL8 PIK3C2A TNF
9 pulmonary hypertension 30.0 ACE EDN1 NOS3 NPPA NPPB REN
10 pulmonary embolism 30.0 CRP F2 NPPB
11 mouth disease 29.9 CRP IL10 IL1B TNF
12 cardiogenic shock 29.9 NPPB PIK3C2A TNF
13 pulmonary hypertension, primary, 1 29.9 EDN1 NPPA NPPB
14 anuria 29.9 ACE PIK3C2A REN
15 rheumatic heart disease 29.8 ACE IL10 TNF
16 congestive heart failure 29.8 ACE EDN1 NPPA NPPB REN
17 bronchiolitis obliterans 29.8 CXCL8 IL10 TNF
18 extrinsic allergic alveolitis 29.8 CXCL8 IL10 IL1B
19 pneumonia 29.8 CRP CXCL8 IL10 IL1B PIK3C2A TNF
20 cardiac tamponade 29.8 F2 NPPB REN
21 acquired immunodeficiency syndrome 29.8 IL10 IL1B TNF
22 aortic coarctation 29.8 ACE EDN1 NOS3
23 plasmodium vivax malaria 29.7 ICAM1 IL10 TNF
24 intracranial hypertension 29.6 F2 IL1B TNF
25 diastolic heart failure 29.6 ACE NOS3 NPPA NPPB
26 mitral valve insufficiency 29.6 ACE NPPA NPPB
27 severe acute respiratory syndrome 29.6 CRP CXCL8 TNF
28 meningitis 29.5 CRP CXCL8 IL10 IL1B TNF
29 interstitial lung disease 29.5 CXCL8 EDN1 IL10 IL1B TNF
30 arthritis 29.5 CXCL8 IL10 IL1B TNF
31 autosomal dominant polycystic kidney disease 29.4 ACE CFTR EDN1 NOS3 REN
32 bronchiolitis 29.4 CRP CXCL8 IL10 TNF
33 pulmonary disease, chronic obstructive 29.3 CFTR CRP CXCL8 HMOX1 NPPB TNF
34 mitral valve disease 29.3 ACE IL10 NOS3 NPPA
35 acute myocardial infarction 29.3 ACE CRP EDN1 NPPA NPPB PIK3C2A
36 malaria 29.2 CRP CXCL8 EDN1 HMOX1 ICAM1 IL10
37 arteries, anomalies of 29.1 ACE CRP EDN1 ICAM1 IL1B NOS3
38 lung disease 29.1 CFTR CXCL8 EDN1 HMOX1 IL10 IL1B
39 hepatorenal syndrome 29.1 ACE EDN1 F2 NPPA REN
40 diabetes mellitus 29.1 ACE CRP EDN1 IL1B NOS3 PIK3C2A
41 arteriosclerosis 29.1 ACE CRP EDN1 HMOX1 ICAM1 IL10
42 renovascular hypertension 29.0 ACE EDN1 HMOX1 NOS3 NPPA REN
43 tetralogy of fallot 29.0 CRP EDN1 NPPA NPPB REN
44 rheumatoid arthritis 29.0 CRP CXCL8 ICAM1 IL10 IL1B TNF
45 systemic lupus erythematosus 28.9 ACE CRP CXCL8 F2 ICAM1 IL10
46 sleep apnea 28.9 ACE CRP CXCL8 EDN1 ICAM1 IL1B
47 atrial fibrillation 28.8 ACE CRP F2 NPPA NPPB
48 pre-eclampsia 28.8 EDN1 F2 HMOX1 ICAM1 IL10 NOS3
49 coronary artery anomaly 28.8 ACE CRP EDN1 F2 NOS3 NPPA
50 vascular disease 28.7 ACE CRP EDN1 F2 HMOX1 NOS3

Graphical network of the top 20 diseases related to Pulmonary Edema:



Diseases related to Pulmonary Edema
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Symptoms & Phenotypes for Pulmonary Edema

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UMLS symptoms related to Pulmonary Edema:


edema, hemoptysis, peau d'orange

GenomeRNAi Phenotypes related to Pulmonary Edema according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.92 ACE CFTR CXCL8 F2 HMOX1 ICAM1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.92 ACE CFTR CXCL8 F2 HMOX1 ICAM1

MGI Mouse Phenotypes related to Pulmonary Edema:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.39 ACE AQP5 CFTR CRP EDN1 F2
2 cardiovascular system MP:0005385 10.38 ACE CRP EDN1 F2 HMOX1 ICAM1
3 growth/size/body region MP:0005378 10.34 ACE AQP5 CFTR EDN1 F2 FGF7
4 behavior/neurological MP:0005386 10.33 ACE AQP5 CFTR F2 FGF7 HMOX1
5 hematopoietic system MP:0005397 10.29 ACE CFTR F2 FGF7 HMOX1 ICAM1
6 immune system MP:0005387 10.25 ACE CFTR CRP F2 FGF7 HMOX1
7 mortality/aging MP:0010768 10.22 ACE AQP5 CFTR EDN1 F2 HMOX1
8 endocrine/exocrine gland MP:0005379 10.16 ACE AQP5 CFTR EDN1 HMOX1 ICAM1
9 digestive/alimentary MP:0005381 10.13 AQP5 CFTR EDN1 F2 ICAM1 IL10
10 muscle MP:0005369 10.07 AQP5 EDN1 HMOX1 ICAM1 IL10 NOS3
11 nervous system MP:0003631 10.06 EDN1 F2 FGF7 ICAM1 IL10 IL1B
12 renal/urinary system MP:0005367 9.91 ACE EDN1 FGF7 HMOX1 NOS3 NPPA
13 reproductive system MP:0005389 9.81 ACE CFTR F2 FGF7 HMOX1 IL10
14 respiratory system MP:0005388 9.56 AQP5 CFTR F2 HMOX1 IL10 NOS3
15 vision/eye MP:0005391 9.23 AQP5 CFTR FGF7 ICAM1 IL10 NOS3
Sources

Drugs & Therapeutics for Pulmonary Edema

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Drugs for Pulmonary Edema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 343)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
2
Morphine Approved, Investigational Phase 4 57-27-2 5288826
3
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
4
Bupivacaine Approved, Investigational Phase 4,Phase 1 2180-92-9, 38396-39-3 2474
5
Dobutamine Approved Phase 4,Phase 3,Not Applicable 34368-04-2 36811
6
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
7
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
8
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
9
Remifentanil Approved Phase 4,Phase 2 132875-61-7 60815
10
Acetazolamide Approved, Vet_approved Phase 4,Not Applicable 59-66-5 1986
11
Propranolol Approved, Investigational Phase 4 525-66-6 4946
12
Verapamil Approved Phase 4 52-53-9 2520
13
Diltiazem Approved, Investigational Phase 4 42399-41-7 39186
14
Metoprolol Approved, Investigational Phase 4,Not Applicable 37350-58-6, 51384-51-1 4171
15
Prednisolone Approved, Vet_approved Phase 4,Not Applicable 50-24-8 5755
16
Methylprednisolone Approved, Vet_approved Phase 4,Not Applicable 83-43-2 6741
17
Prednisolone phosphate Approved, Vet_approved Phase 4,Not Applicable 302-25-0
18
Methylprednisolone hemisuccinate Approved Phase 4,Not Applicable 2921-57-5
19
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 2 113775-47-6 68602 5311068
20
Nifedipine Approved Phase 4,Not Applicable 21829-25-4 4485
21
Benzocaine Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 94-09-7, 1994-09-7 2337
22 tannic acid Approved Phase 4,Phase 1,Phase 2,Not Applicable
23
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 7487-88-9 24083
24
Milrinone Approved Phase 4 78415-72-2 4197
25
Terlipressin Approved, Investigational Phase 4 14636-12-5 72081
26
Lypressin Approved Phase 4 50-57-7
27
Labetalol Approved Phase 4 36894-69-6 3869
28
Esmolol Approved Phase 4 103598-03-4, 81147-92-4 59768
29
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
30
Cefuroxime Approved Phase 4 55268-75-2 5361202 5479529
31
Metronidazole Approved Phase 4 443-48-1 4173
32
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
33
Zinc Approved, Investigational Phase 4 7440-66-6
34
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Early Phase 1,Not Applicable 77-92-9 311
35
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
36
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
37
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 5280795 6221
38
Prednisolone hemisuccinate Experimental Phase 4,Not Applicable 2920-86-7
39 Anesthetics, General Phase 4,Phase 2
40 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
41 GABA Modulators Phase 4
42 Anti-Anxiety Agents Phase 4
43 Analgesics, Opioid Phase 4,Phase 2,Phase 1,Not Applicable
44 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
45 Adjuvants, Anesthesia Phase 4
46 Narcotics Phase 4,Phase 2,Not Applicable
47 Analgesics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
48 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
49 Anesthetics, Intravenous Phase 4,Phase 2
50 Tranquilizing Agents Phase 4,Phase 1

Interventional clinical trials:

(show top 50) (show all 403)
# Name Status NCT ID Phase Drugs
1 MIdazolam Versus MOrphine in Acute Pulmonary Edema (MIMO Trial) Unknown status NCT02856698 Phase 4 Midazolam;Morphine
2 Impact of Fluid Resuscitation Therapy on Pulmonary Edema as Measured by Alveolar Fluid Clearance in Patients With Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT01763853 Phase 4 4% albumin
3 Comparison of Nasal CPAP and Nasal SIMV in Transient Tachypnea of Newborn Unknown status NCT01499238 Phase 4
4 Effects of Atorvastatin Treatment on Left Ventricular Diastolic Function in Peritoneal Dialysis Patients Unknown status NCT01503671 Phase 4 Atorvastatin
5 A Comparison of Two Anaesthetic Methods of Protecting Heart Tissue During Cardiac Surgery Unknown status NCT00244283 Phase 4 Sevoflurane
6 Comparative Study of Non-Invasive Mask Ventilation vs Cuirass Ventilation in Patients With Acute Respiratory Failure. Unknown status NCT00331656 Phase 4
7 Prevention of Contrast Nephropathy During Diagnostic Coronary Angiogram or PCI With Hydratation Based on LEVDP Unknown status NCT00584350 Phase 4
8 Hemocontrol's Effectiveness on the Reduction of Cardiovascular Long-term EventS Unknown status NCT01515878 Phase 4
9 Non Invasive Mechanical Ventilation in Acute Cardiogenic Pulmonary Edema Completed NCT00912158 Phase 4
10 Non-Invasive Ventilation in Pulmonary Edema Completed NCT00453947 Phase 4
11 CPAP Versus NPPV in ACPE Completed NCT00446498 Phase 4
12 OUT-OF-HOSPITAL CPAP STUDY Completed NCT00439075 Phase 4 standard treatment
13 Evaluating Fluid Strategies in Thoracic Surgery Patients Utilizing a Goal Directed Approach Completed NCT02135146 Phase 4 Plasmalyte 3ml/kg/hr group;Plasmalyte 6ml/kg/hr group
14 Randomized, Controlled Trial of Regular Sildenafil Citrate in the Prevention of Altitude Illness Completed NCT00627965 Phase 4 Sildenafil citrate;Placebo
15 Efficacy Study of Riociguat and Its Effects on Exercise Performance and Pulmonary Artery Pressure at High Altitude Completed NCT02024386 Phase 4 Riociguat
16 Acute Chest Pain Treatment and Evaluation (ACTION) Study Completed NCT00434564 Phase 4
17 Diffuse Acute Respiratory Distress Syndrome (ARDS), Recruitment Maneuver, and sRAGE (DAMAGE Study) Completed NCT01600651 Phase 4
18 Beta-Blocker Continuation Versus Interruption in Heart Failure Worsening Completed NCT00162565 Phase 4 beta-blocker treatment
19 Electromyographic Activity of the Respiratory Muscles During Neostigmine or Sugammadex Enhanced Recovery After Neuromuscular Blockade Completed NCT02403063 Phase 4 Sugammadex;Neostigmine;Neostigmine-sugammadex
20 Effect-site Concentration of Remifentanil for Smooth Removal of the Double-lumen Endotracheal Tube Completed NCT02528825 Phase 4 Remifentanil titration
21 Acetazolamide for the Prevention of High Altitude Illness: a Comparison of Dosing Completed NCT01993667 Phase 4 Acetazolamide
22 NAVISTAR® THERMOCOOL® Catheter Post Approval Registry Completed NCT00964392 Phase 4
23 Erythropoietin in the Prevention of Acute Mountain Sickness Completed NCT01665781 Phase 4 Erythropoietin
24 Restricted Fluid Therapy in Colorectal Surgery Completed NCT03537989 Phase 4 Saline
25 Rate Control in Atrial Fibrillation Completed NCT01655303 Phase 4 Propranolol;Metoprolol;Verapamil;Diltiazem
26 REstrictive Versus LIbEral Fluid Therapy in Major Abdominal Surgery: RELIEF Study Completed NCT01424150 Phase 4
27 Steroids in Fulminant Hepatitis A in the Pediatric Age Group Completed NCT02375867 Phase 4 prednisolone;methylprednisolone
28 Lumbar Plexus Block Upon the Incidence of Ischemic Cardiovascular Events in Elderly Patients With Hip Fracture Completed NCT01961895 Phase 4 Intravenous patient-controlled analgesia
29 Southwest German Interventional Study in Acute Myocardial Infarction III Completed NCT01124890 Phase 4
30 Milrinone Versus Dobutamine in Critically Ill Patients Recruiting NCT03207165 Phase 4 Milrinone;Dobutamine
31 Efficacy of Terlipressin Therapy in Acute Variceal Haemorrhage After EVL Recruiting NCT03584087 Phase 4 Normal Saline;Terlipressin
32 A Randomized Control Trial of Vitamin D Prophylaxis in the Prevention of Hypertensive Disorders of Pregnancy Recruiting NCT02920593 Phase 4 Vitamin D3
33 The Effect of Dexmedetomidine on Airway Complications After Deep or Awake Extubation Recruiting NCT02162433 Phase 4 Normal Saline;Dexmedetomidine
34 Evaluation of VISITAG SURPOINTâ„¢ Module With External Processing Unit (EPU) Recruiting NCT03624881 Phase 4
35 Chronic Hypertension and Pregnancy (CHAP) Project Recruiting NCT02299414 Phase 4 Anti-hypertensive therapy
36 Evaluation of Early CRRT and Beta-blocker InTerventions in Patients With ECMO(ELITE) Recruiting NCT03549923 Phase 4 Esmolol;Standard care
37 Prophylaxis of Ileostomy Closure Site Hernia by Placing Mesh Recruiting NCT02226887 Phase 4
38 Parenteral Antibiotics Compared to Combination of Oral and Parenteral Antibiotics in Colorectal Surgery Prophylaxis Recruiting NCT02505581 Phase 4 Extra dosage - cefuroxime (750mg) I.V;Cefuroxime 750mg oral;Metronidazole 250mg oral;Metronidazole 1,5gr Intravenous;Cefuroxime 1g Intravenous
39 Paramedic Initiated Treatment of Sepsis Targeting Out-of-hospital Patients (PITSTOP) Not yet recruiting NCT03068741 Phase 4 Comparison 1: Prehospital Ceftriaxone;Comparison 1: Placebo;Comparison 2: Liberal fluids;Comparison 2: Conservative fluids
40 Effect of Acetazolamide on Subclinical High-Altitude Pulmonary Edema Detected by Lung Ultrasonography Terminated NCT03490916 Phase 4 Acetazolamide;Placebo
41 Normoglycemia and Neurological Outcome Terminated NCT01137773 Phase 4 Insulin;Conventional insulin treatment
42 Different Schemes of Magnesium Sulfate for Preeclampsia Terminated NCT02396030 Phase 4 Magnesium sulfate 50% - 1g/h;Magnesium sulfate 50% - 2g/h
43 Double Blind Randomized Placebo Controlled Trial of Natrecor in Acute Decompensated Heart Failure With Normal EF Withdrawn NCT00505791 Phase 4 Nesiritide
44 High-Dose Aldactone for Treatment of Diuretic Resistant Heart Failure Withdrawn NCT02429388 Phase 4 Spironolactone
45 Transfusion Strategy in Hematological Intensive Care Unit Unknown status NCT02461264 Phase 3 Single red blood packed cells Transfusion;Two packed red blood cells Transfusion
46 Bilevel Positive Pressure Ventilation (BIPAP)in Patients With Sleep Disorders Breathing (SDB)and Congestive Heart Failure (CHF):Comparison of Two Diagnostic Methods Unknown status NCT01501734 Phase 3
47 Transfusion Requirements in Critically Ill Oncologic Patient Unknown status NCT01648946 Phase 3
48 Concomitant Tracheostomy and Lung Resection Unknown status NCT01053624 Phase 3
49 Single Bolus Recombinant Nonimmunogenic Staphylokinase (FORtelyzin) Versus Single Bolus Tenecteplase (Metalyse) in STEMI Unknown status NCT02301910 Phase 3 Recombinant staphylokinase;Tenecteplase
50 Out-of-Hospital CPAP for Severe Cardiogenic Pulmonary Edema Completed NCT00390442 Phase 3

Search NIH Clinical Center for Pulmonary Edema

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: pulmonary edema

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Genetic Tests for Pulmonary Edema

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Anatomical Context for Pulmonary Edema

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MalaCards organs/tissues related to Pulmonary Edema:

41
Lung, Heart, Kidney, Brain, Endothelial, Liver, Skin
Sources

Publications for Pulmonary Edema

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Articles related to Pulmonary Edema:

(show top 50) (show all 1387)
# Title Authors Year
1
Pressure support ventilation vs continuous positive airway pressure for treating of acute cardiogenic pulmonary edema. Comment. ( 30165137 )
2019
2
Negative pressure pulmonary edema. ( 29441178 )
2018
3
New insights into the mechanisms of pulmonary edema in acute lung injury. ( 29430449 )
2018
4
Elevated Vasodilatory Cyclases and Shorter Telomere Length Contribute to High-Altitude Pulmonary Edema. ( 29443612 )
2018
5
The Key Roles of Negative Pressure Breathing and Exercise in the Development of Interstitial Pulmonary Edema in Professional Male SCUBA Divers. ( 29299780 )
2018
6
Naloxone-Induced Non-Cardiogenic Pulmonary Edema: A Case Report. ( 29749582 )
2018
7
High-Altitude Acute Pulmonary Edema after 48 Hours in a Ski Station. ( 29871767 )
2018
8
Non-Invasive Mechanical Ventilation Compared to Positive Airway Pressure in Cardiogenic Pulmonary Edema. ( 29859635 )
2018
9
Acute pulmonary edema induced by non-ionic low-osmolar radiographic contrast media. ( 29942165 )
2018
10
Postictal neurogenic pulmonary edema: Case report and brief literature review. ( 29692972 )
2018
11
Refractory Pulmonary Edema and Upper Body Hypoxemia During Veno-Arterial Extracorporeal Membrane Oxygenation-A Case for Atrial Septostomy. ( 29344963 )
2018
12
Regional Negative Pressure Pulmonary Edema with Pulmonary Thromboembolism. ( 29434139 )
2018
13
Predicting cardiogenic pulmonary edema in heart failure patients by using an N-terminal pro-b-type natriuretic peptide (NT-pro BNP) -based score. ( 29408167 )
2018
14
Sequencing the exons of human glucocorticoid receptor (NR3C1) gene in Han Chinese with high-altitude pulmonary edema. ( 29587872 )
2018
15
Neurogenic Pulmonary Edema and Stunned Myocardium in a Patient With Meningioma: A Heart-Brain Cross Talk. ( 29432276 )
2018
16
Response to "The wider implications of AD-related AR and pulmonary edema". ( 29936009 )
2018
17
Identification of Pulmonary Edema in Forensic Autopsy Cases of Sudden Cardiac Death Using Fourier Transform Infrared Microspectroscopy: A Pilot Study. ( 29364657 )
2018
18
Sensitivity and specificity of ultrasound for the diagnosis of acute pulmonary edema: a systematic review and meta-analysis. ( 29400365 )
2018
19
Aortic dissection presenting with acute pulmonary edema. ( 29709400 )
2018
20
Pulmonary Edema and Diastolic Heart Failure in the Perioperative Period. ( 29607222 )
2018
21
Correlation analysis on serum inflammatory cytokine level and neurogenic pulmonary edema for children with severe hand-foot-mouth disease. ( 29724230 )
2018
22
Pulmonary edema post-adenotonsillectomy in children. ( 29915848 )
2018
23
Correction to: Correlation analysis on serum inflammatory cytokine level and neurogenic pulmonary edema for children with severe hand-foot-mouth disease. ( 29907161 )
2018
24
HMOX1 Promoter Microsatellite Polymorphism and High Altitude Pulmonary Edema in Han Chinese Men. ( 29398188 )
2018
25
Thoracic fluid content: a novel parameter for detection of pulmonary edema in parturients with preeclampsia. ( 29936563 )
2018
26
Upfront triple combination therapy-induced pulmonary edema in a case of pulmonary arterial hypertension associated with Sjogren's syndrome. ( 29276674 )
2018
27
Transcriptomic profiling reveals gene expression kinetics in patients with hypoxia and high altitude pulmonary edema. ( 29366758 )
2018
28
Response to: Comment on "Soluble Urokinase-Type Plasminogen Activator Receptor Plasma Concentration May Predict Susceptibility to High Altitude Pulmonary Edema". ( 29853793 )
2018
29
Diving, Immersion Pulmonary Edema ( 29763028 )
2018
30
Treating acute hypertensive cardiogenic pulmonary edema with high-dose nitroglycerin. ( 29942881 )
2018
31
High altitude trekking after lung transplantation: a prospective study using lung ultrasound to detect comets tails for interstitial pulmonary edema in lung transplant recipients and healthy volunteers. ( 29928768 )
2018
32
Recognition of Sympathetic Crashing Acute Pulmonary Edema (SCAPE) and use of high-dose nitroglycerin infusion. ( 29776826 )
2018
33
Mast cells contribute to Enterovirus 71 infection-induced pulmonary edema in neonatal mice. ( 29765110 )
2018
34
Effects of Medium Molecular Weight Heparinyl Arginine on Scorpion Venom-induced Pulmonary Edema in Rats. ( 29695557 )
2018
35
Pressure support ventilation vs Continuous positive airway pressure for treating of acute cardiogenic pulmonary edema: A pilot study. ( 29702222 )
2018
36
Acute noncardiogenic pulmonary edema after neostigmine administration during the recovery period of general anesthesia: A case report. ( 29794728 )
2018
37
Fulminant adrenergic myocarditis complicated by pulmonary edema, cardiogenic shock and cardiac arrest. ( 29146416 )
2018
38
Sitagliptin-induced diffuse alveolar hemorrhage mimicking pulmonary edema. ( 30090803 )
2018
39
Concurrent occurrence of acute bovine pulmonary edema and emphysema and endocardial fibroelastosis in cattle: A case history and literature review. ( 30147268 )
2018
40
HELLP Syndrome Complicated By Pulmonary Edema: A Case Report. ( 30426089 )
2018
41
p-Coumaric acid as a prophylactic measure against normobaric hypoxia induced pulmonary edema in mice. ( 30248349 )
2018
42
Preliminary Results: Can Dual-Energy Computed Tomography Help Distinguish Cardiogenic Pulmonary Edema and Acute Interstitial Lung Disease? ( 28708723 )
2018
43
The role of serum procalcitonin in the differential diagnosis of pneumonia from pulmonary edema among the patients with pulmonary infiltrates on chest radiography. ( 30461655 )
2018
44
Pulmonary edema ex vacuo after drainage of pneumothorax. ( 29150308 )
2018
45
Independent lung ventilation for the management of unilateral reperfusion pulmonary edema after pulmonary thrombendarterectomy: A case report. ( 30412773 )
2018
46
Negative pressure pulmonary edema after percutaneous endoscopic interlaminar lumbar discectomy-a case report. ( 30428864 )
2018
47
The breathless swimmer: could this be swimming-induced pulmonary edema? ( 30456500 )
2018
48
Transthoracic lung and pleura ultrasonography as a diagnostic tool of pulmonary edema in dogs and cats. ( 30468335 )
2018
49
Detecting pulmonary edema in multiple pregnancy through point-of-care lung ultrasonography. ( 30477995 )
2018
50
Design and Optimization of Sulfone Pyrrolidine Sulfonamide Antagonists of Transient Receptor Potential Vanilloid-4 (TRPV4) with In Vivo Activity in a Pulmonary Edema Model. ( 30500190 )
2018
Sources

Variations for Pulmonary Edema

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Expression for Pulmonary Edema

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Search GEO for disease gene expression data for Pulmonary Edema.
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Pathways for Pulmonary Edema

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Pathways related to Pulmonary Edema according to GeneCards Suite gene sharing:

(show all 42)
# Super pathways Score Top Affiliating Genes
1
Cytokine Signaling in Immune system 66
Show member pathways
 13.32 CXCL8 FGF7 HMOX1 ICAM1 IL10 IL1B
2
Immune response IL-23 signaling pathway 22
Show member pathways
 12.55 F2 IL10 IL1B NOS3 TNF
3
Insulin receptor recycling 66
Show member pathways
 12.43 CFTR CXCL8 HMOX1 NOS3
4
IL-17 Family Signaling Pathways 65
Show member pathways
 12.29 CFTR CXCL8 IL1B TNF
5
Selenium Micronutrient Network 1
Show member pathways
 12.27 CRP F2 ICAM1 IL1B TNF
6
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.23 CXCL8 FGF7 IL10 IL1B TNF
7
Bacterial infections in CF airways 22
Show member pathways
 12.16 CFTR CXCL8 IL1B TNF
8
IL-1 Family Signaling Pathways 65
Show member pathways
 12.16 CFTR CXCL8 EDN1 HMOX1 IL1B TNF
9
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.15 CXCL8 IL10 IL1B TNF
10
MicroRNAs in cardiomyocyte hypertrophy 1
Show member pathways
 12.13 EDN1 NPPA NPPB TNF
11
Immune response IFN gamma signaling pathway 22
Show member pathways
 12.04 CXCL8 FGF7 ICAM1 IL10 IL1B
12
Spinal Cord Injury 1
11.99 CXCL8 ICAM1 IL1B TNF
13
TNF signaling pathway 37
11.93 EDN1 ICAM1 IL1B TNF
14
HIF-1 signaling pathway 37
11.88 EDN1 HMOX1 NOS3 NPPA
15
Amoebiasis 37
11.85 CXCL8 IL10 IL1B TNF
16
NF-kappa B signaling pathway 37
11.84 CXCL8 ICAM1 IL1B TNF
17
Cytokine production by Th17 cells in CF (Mouse model) 22
Show member pathways
 11.83 CFTR CXCL8 ICAM1
18
Angiogenesis (CST) 4
11.8 HMOX1 NOS3 REN
19
Rheumatoid arthritis 37
11.8 CXCL8 ICAM1 IL1B TNF
20
Interleukin-4 and 13 signaling 66
11.79 CXCL8 HMOX1 ICAM1 IL10 IL1B TNF
21
Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics 61
Show member pathways
 11.75 ACE NOS3 REN
22
Innate Lymphoid Cell Differentiation Pathways 65
11.75 IL10 IL1B TNF
23
Dendritic Cells Developmental Lineage Pathway 65
11.71 IL10 IL1B TNF
24
Pertussis 37
11.71 CXCL8 IL10 IL1B TNF
25
Microglia Activation During Neuroinflammation: Microglia Polarization 65
11.69 IL10 IL1B TNF
26
Fluid shear stress and atherosclerosis 37
11.64 EDN1 HMOX1 ICAM1 IL1B NOS3 TNF
27
AGE-RAGE signaling pathway in diabetic complications 37
11.63 CXCL8 EDN1 ICAM1 IL1B NOS3 TNF
28
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.6 CXCL8 ICAM1 IL1B TNF
29
Legionellosis 37
11.56 CXCL8 IL1B TNF
30
Interleukin-10 signaling 66
11.46 CXCL8 ICAM1 IL10 IL1B TNF
31
Malaria 37
11.41 CXCL8 ICAM1 IL10 IL1B TNF
32
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
11.32 CXCL8 HMOX1 NOS3
33
African trypanosomiasis 37
11.32 ICAM1 IL10 IL1B TNF
34
IL-10 Pathway 64
11.3 HMOX1 IL10 IL1B TNF
35
Cytokines and Inflammatory Response 1
11.24 IL10 IL1B TNF
36
G-protein signaling_RhoB regulation pathway 22
11.18 CXCL8 IL10 IL1B TNF
37
IL1 and megakaryocytes in obesity 1
11.16 F2 ICAM1 IL1B
38
G-protein signaling_Rap2B regulation pathway 22
10.98 CXCL8 FGF7 IL10 IL1B TNF
39
Overview of nanoparticle effects 1
10.98 CRP CXCL8 HMOX1 TNF
40
Lung fibrosis 1
10.9 CXCL8 EDN1 FGF7 HMOX1 IL1B TNF
41
LDL Oxidation in Atherogenesis 64
10.89 ICAM1 IL1B TNF
42
NO-dependent CFTR activation (normal and CF) 22
10.8 CFTR NOS3
Sources

GO Terms for Pulmonary Edema

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Cellular components related to Pulmonary Edema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 ACE CRP CXCL8 EDN1 F2 FGF7
2 extracellular space GO:0005615 9.44 ACE CRP CXCL8 EDN1 F2 HMOX1

Biological processes related to Pulmonary Edema according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.98 EDN1 ICAM1 IL10 IL1B REN
2 positive regulation of angiogenesis GO:0045766 9.9 CXCL8 HMOX1 IL1B NOS3
3 response to organic substance GO:0010033 9.89 IL10 REN TNF
4 neutrophil chemotaxis GO:0030593 9.89 CXCL8 EDN1 IL1B
5 positive regulation of JNK cascade GO:0046330 9.89 IL1B TNF TRPV4
6 cellular response to interleukin-1 GO:0071347 9.88 CXCL8 EDN1 ICAM1
7 cytokine-mediated signaling pathway GO:0019221 9.88 CXCL8 HMOX1 ICAM1 IL10 IL1B TNF
8 response to glucocorticoid GO:0051384 9.86 IL10 IL1B TNF
9 cellular response to drug GO:0035690 9.85 EDN1 IL1B REN
10 response to hypoxia GO:0001666 9.85 EDN1 HMOX1 ICAM1 IL1B NPPA
11 positive regulation of DNA-binding transcription factor activity GO:0051091 9.84 EDN1 IL10 IL1B TNF
12 positive regulation of smooth muscle cell proliferation GO:0048661 9.83 EDN1 HMOX1 TNF
13 cellular response to lipopolysaccharide GO:0071222 9.83 CXCL8 ICAM1 IL10 IL1B TNF
14 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.81 EDN1 IL1B TNF
15 response to insulin GO:0032868 9.8 ICAM1 IL10 NPPA TRPV4
16 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.79 EDN1 IL10 TNF
17 positive regulation of JUN kinase activity GO:0043507 9.77 EDN1 IL1B TNF
18 lipopolysaccharide-mediated signaling pathway GO:0031663 9.75 IL1B NOS3 TNF
19 response to lipopolysaccharide GO:0032496 9.73 EDN1 ICAM1 IL10 IL1B NOS3 REN
20 response to dexamethasone GO:0071548 9.72 EDN1 IL1B
21 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.72 HMOX1 ICAM1 NOS3
22 response to molecule of bacterial origin GO:0002237 9.71 CXCL8 IL10
23 angiotensin maturation GO:0002003 9.71 ACE REN
24 cGMP biosynthetic process GO:0006182 9.7 NPPA NPPB
25 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.7 IL1B TRPV4
26 receptor guanylyl cyclase signaling pathway GO:0007168 9.7 NPPA NPPB
27 body fluid secretion GO:0007589 9.69 EDN1 NPPB
28 multicellular organismal water homeostasis GO:0050891 9.69 CFTR TRPV4
29 negative regulation of lipid storage GO:0010888 9.69 CRP TNF
30 positive regulation of neutrophil chemotaxis GO:0090023 9.69 CXCL8 EDN1 IL1B
31 negative regulation of platelet activation GO:0010544 9.68 F2 NOS3
32 endothelial cell apoptotic process GO:0072577 9.68 IL10 TNF
33 positive regulation of prostaglandin secretion GO:0032308 9.67 EDN1 IL1B
34 regulation of establishment of endothelial barrier GO:1903140 9.67 IL1B TNF
35 positive regulation of nitric oxide biosynthetic process GO:0045429 9.67 EDN1 ICAM1 IL1B TNF
36 negative regulation of cytokine secretion involved in immune response GO:0002740 9.65 IL10 TNF
37 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.65 ICAM1 TNF
38 positive regulation of neuroinflammatory response GO:0150078 9.65 IL1B TNF
39 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.65 IL10 IL1B TNF
40 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.64 EDN1 NOS3
41 positive regulation of fever generation GO:0031622 9.63 IL1B TNF
42 response to ozone GO:0010193 9.62 EDN1 IL1B
43 chronic inflammatory response to antigenic stimulus GO:0002439 9.61 IL1B TNF
44 sequestering of triglyceride GO:0030730 9.61 IL1B TNF
45 regulation of signaling receptor activity GO:0010469 9.61 CXCL8 EDN1 F2 FGF7 IL10 IL1B
46 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.57 IL1B TNF
47 receptor biosynthetic process GO:0032800 9.56 IL10 TNF
48 smooth muscle hyperplasia GO:0014806 9.52 HMOX1 NOS3
49 positive regulation of chemokine biosynthetic process GO:0045080 9.5 HMOX1 IL1B TNF
50 regulation of blood vessel size GO:0050880 9.46 EDN1 NOS3 NPPA NPPB

Molecular functions related to Pulmonary Edema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.89 AQP5 CFTR CRP CXCL8 EDN1 F2
2 signaling receptor binding GO:0005102 9.65 EDN1 F2 NPPA NPPB REN
3 hormone receptor binding GO:0051427 9.16 NPPA NPPB
4 cytokine activity GO:0005125 9.02 CXCL8 EDN1 IL10 IL1B TNF
Sources

Sources for Pulmonary Edema

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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