Aliases & Classifications for Pulmonary Edema

MalaCards integrated aliases for Pulmonary Edema:

Name: Pulmonary Edema 12 43 15 17 71


External Ids:

Disease Ontology 12 DOID:11396
MeSH 43 D011654
NCIt 49 C26868
SNOMED-CT 67 19242006
ICD10 32 J81
UMLS 71 C0034063

Summaries for Pulmonary Edema

MalaCards based summary : Pulmonary Edema is related to acute mountain sickness and adult respiratory distress syndrome, and has symptoms including edema, hemoptysis and peau d'orange. An important gene associated with Pulmonary Edema is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Toll-like Receptor Signaling Pathway. The drugs Simvastatin and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and endothelial, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and Increased viability with MLN4924 (a NAE inhibitor)

Wikipedia : 74 Pulmonary edema is fluid accumulation in the tissue and air spaces of the lungs. It leads to impaired... more...

Related Diseases for Pulmonary Edema

Diseases related to Pulmonary Edema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1035)
# Related Disease Score Top Affiliating Genes
1 acute mountain sickness 34.3 PIK3C2A NOS3 EDN1 ACE
2 adult respiratory distress syndrome 33.8 TNF IL1B IL10 FGF7 F2 CXCL8
3 chronic mountain sickness 33.3 NPPB NOS3 EDN1
4 silicosis 32.3 TNF IL1B IL10 HMOX1 CXCL8 ACE
5 cardiogenic shock 31.6 PIK3C2A NPPB CRP
6 mitral valve stenosis 31.2 SERPINC1 REN NPPB F2 CRP ACE
7 pulmonary embolism 31.2 TNNI3 SERPINC1 NPPB F2 CRP ACE
8 pheochromocytoma 31.2 TNF REN KNG1 EDN1 ACE
9 chronic thromboembolic pulmonary hypertension 31.2 NPPB EDN1 CRP
10 mitral valve insufficiency 31.2 TNNI3 REN PIK3C2A NPPB F2 CRP
11 acute kidney failure 31.1 REN PIK3C2A KNG1 F2
12 kidney disease 31.1 REN NPPB NOS3 HMOX1 EDN1 CRP
13 pulmonary fibrosis 31.1 IL1B FGF7 EDN1 CXCL8
14 respiratory failure 31.0 TNF REN PIK3C2A NPPB IL1B IL10
15 aspiration pneumonia 31.0 PIK3C2A F2 CRP ACE
16 intracranial hypertension 31.0 TNF SERPINC1 NPPB IL1B F2
17 end stage renal disease 31.0 TNF REN NOS3 CRP ACE
18 neutropenia 31.0 TNF IL1B IL10 CXCL8 CRP
19 arteriovenous malformation 30.9 TNF IL1B EDN1
20 eclampsia 30.9 TNF SERPINC1 REN NOS3 F2 EDN1
21 infective endocarditis 30.9 TNNI3 TNF F2 CRP
22 pancreatitis 30.9 TNF IL1B IL10 CRP
23 aspiration pneumonitis 30.9 TNF CXCL8 CRP
24 orthostatic intolerance 30.8 REN NOS3 EDN1 ACE
25 bronchiolitis 30.8 TNF IL10 CXCL8 CRP
26 poliomyelitis 30.8 TNF IL10 ICAM1
27 toxic shock syndrome 30.8 TNF SERPINC1 IL1B IL10 CXCL8 CRP
28 diastolic heart failure 30.8 TNNI3 REN NPPB NOS3 ACE
29 acute pancreatitis 30.8 TNF IL1B IL10 CXCL8 CRP
30 congestive heart failure 30.8 TNNI3 TNF REN PIK3C2A NPPB NOS3
31 plasmodium falciparum malaria 30.8 TNF IL10 ICAM1 CRP
32 rheumatic fever 30.8 TNF NPPB IL10 ICAM1 ACE
33 coronary heart disease 1 30.8 NPPB NOS3 EDN1 CRP ACE
34 uremia 30.8 TNF REN CRP ACE
35 bronchopneumonia 30.8 TNF IL1B IL10 CXCL8 CRP
36 cardiac arrest 30.8 REN PIK3C2A NPPB KNG1 ICAM1 HMOX1
37 newborn respiratory distress syndrome 30.8 IL1B FGF7 CXCL8 CRP
38 atrioventricular block 30.8 TNNI3 PIK3C2A NPPB ACE
39 patent ductus arteriosus 1 30.7 REN NPPB EDN1 CRP ACE
40 renal artery disease 30.7 REN NOS3 ACE
41 ischemia 30.7 PIK3C2A NPPB NOS3 KNG1 ICAM1 HMOX1
42 brain edema 30.7 KNG1 IL1B HMOX1 CRP AQP5
43 heart valve disease 30.7 TNNI3 REN NPPB IL1B F2 CRP
44 cardiac tamponade 30.7 TNNI3 REN PIK3C2A NPPB F2 CRP
45 pulmonary tuberculosis 30.7 TNF IL1B IL10 CRP
46 bacterial pneumonia 30.7 TNF IL1B IL10 CXCL8 CRP
47 laryngitis 30.7 TNF IL1B CRP
48 right bundle branch block 30.7 TNNI3 NPPB ACE
49 myocarditis 30.7 TNNI3 TNF PIK3C2A NPPB IL1B IL10
50 pulmonary emphysema 30.6 NOS3 HMOX1 FGF7 CXCL8

Graphical network of the top 20 diseases related to Pulmonary Edema:

Diseases related to Pulmonary Edema

Symptoms & Phenotypes for Pulmonary Edema

UMLS symptoms related to Pulmonary Edema:

edema, hemoptysis, peau d'orange

GenomeRNAi Phenotypes related to Pulmonary Edema according to GeneCards Suite gene sharing:

# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-1 9.65 ACE F2 HMOX1 ICAM1
2 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-2 9.65 ACE F2 HMOX1 IL10 IL1B TNF
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.47 CXCL8 IL10 IL1B REN TNF
4 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.47 ACE CXCL8 HMOX1 ICAM1 IL10 IL1B
5 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 9.47 ICAM1

MGI Mouse Phenotypes related to Pulmonary Edema:

# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.33 ACE CRP EDN1 F2 HMOX1 ICAM1
2 homeostasis/metabolism MP:0005376 10.3 ACE AQP5 CRP EDN1 F2 FGF7
3 growth/size/body region MP:0005378 10.28 ACE AQP5 EDN1 F2 FGF7 HMOX1
4 behavior/neurological MP:0005386 10.26 ACE AQP5 F2 FGF7 HMOX1 IL10
5 hematopoietic system MP:0005397 10.18 ACE F2 FGF7 HMOX1 ICAM1 IL10
6 immune system MP:0005387 10.13 ACE CRP F2 FGF7 HMOX1 ICAM1
7 mortality/aging MP:0010768 10.1 ACE AQP5 EDN1 F2 HMOX1 ICAM1
8 muscle MP:0005369 9.85 AQP5 EDN1 HMOX1 ICAM1 IL10 NOS3
9 renal/urinary system MP:0005367 9.61 ACE EDN1 FGF7 HMOX1 NOS3 PIK3C2A
10 respiratory system MP:0005388 9.23 AQP5 F2 HMOX1 IL10 NOS3 TNF

Drugs & Therapeutics for Pulmonary Edema

Drugs for Pulmonary Edema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 277)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Simvastatin Approved Phase 4 79902-63-9 54454
Azithromycin Approved Phase 4 83905-01-5 447043 55185
Lisinopril Approved, Investigational Phase 4 76547-98-3, 83915-83-7 5362119
Clarithromycin Approved Phase 4 81103-11-9 84029
Remifentanil Approved Phase 4 132875-61-7 60815
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
Riociguat Approved Phase 4 625115-55-1
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
Doxazosin Approved Phase 4 74191-85-8 3157
Phenoxybenzamine Approved Phase 4 59-96-1 4768
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
Morphine Approved, Investigational Phase 4 57-27-2 5288826
Dobutamine Approved Phase 4 34368-04-2 36811
Oxytocin Approved, Vet_approved Phase 4 50-56-6 53477758 439302
Ibuprofen Approved Phase 4 15687-27-1 3672
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
Hydralazine Approved Phase 4 86-54-4 3637
Esmolol Approved Phase 4 103598-03-4, 81147-92-4 59768
Milrinone Approved Phase 4 78415-72-2 4197
Acetaminophen Approved Phase 4 103-90-2 1983
Sotalol Approved Phase 4 3930-20-9, 959-24-0 5253
Acetazolamide Approved, Vet_approved Phase 4 59-66-5 1986
tannic acid Approved Phase 4 1401-55-4
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
Angiotensin II Approved, Investigational Phase 4 4474-91-3, 11128-99-7, 68521-88-0 172198
Amlodipine Approved Phase 4 88150-42-9 2162
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
Zinc Approved, Investigational Phase 4 7440-66-6 32051
30 Anesthetics, Intravenous Phase 4
protease inhibitors Phase 4
32 HIV Protease Inhibitors Phase 4
33 Rosuvastatin Calcium Phase 4 147098-20-2
34 Analgesics, Opioid Phase 4
35 Ophthalmic Solutions Phase 4
36 Plasma-lyte 148 Phase 4
37 Anti-Bacterial Agents Phase 4
38 Antibiotics, Antitubercular Phase 4
39 Adrenergic alpha-Antagonists Phase 4
40 Adrenergic alpha-1 Receptor Antagonists Phase 4
41 Cholinergic Agents Phase 4
42 Cholinesterase Inhibitors Phase 4
Glycopyrrolate Phase 4 596-51-0 3494
44 Cola Phase 4
45 Phosphodiesterase Inhibitors Phase 4
46 Anti-Inflammatory Agents Phase 4
47 Narcotics Phase 4
48 Hypnotics and Sedatives Phase 4
49 Analgesics Phase 4
50 Anti-Anxiety Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 415)
# Name Status NCT ID Phase Drugs
1 Impact of Fluid Resuscitation Therapy on Pulmonary Edema as Measured by Alveolar Fluid Clearance in Patients With Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT01763853 Phase 4 4% albumin
2 Remifentanil for c-Section With General Anesthesia in Severe Preeclamptic Patients Unknown status NCT00567957 Phase 4 Remifentanil;Saline
3 Non-Invasive Positive Pressure Mask Ventilation vs Extrathoracic Biphasic Cuirass Ventilation in Patients With Acute Respiratory Failure: A Randomized Prospective Study. Unknown status NCT00331656 Phase 4
4 MICROS-Pilot Study Microcirculation In Acute Coronary Syndromes; Effect of Pre-treatment of High Dose Rosuvastatin on Coronary Microcirculation in Primary PCI Unknown status NCT01382472 Phase 4 Rosuvastatin;Simvastatin
5 Impact of Antichlamydial Treatment on the Rate of Preeclampsia Among Egyptian Primigravidae: a Randomized Controlled Trial Unknown status NCT03233880 Phase 4 Azithromycin 1gm
6 Effects of Atorvastatin Treatment on Left Ventricular Diastolic Function in Peritoneal Dialysis Patients (ALEVENT) Unknown status NCT01503671 Phase 4 Atorvastatin
7 Prophylactic Lisinopril to Prevent Anthracycline Induced Left Ventricular Systolic Dysfunction (PLAID) Study. Unknown status NCT03392740 Phase 4 Lisinopril;Placebo Oral Tablet
8 CPAP Versus BiPAP in Acute Cardiogenic Pulmonary Edema: Experience With 129 Patients Completed NCT00912158 Phase 4
9 Continuous Positive Airway Pressure Versus Non-Invasive Positive Pressure Support Ventilation in Acute Cardiogenic Pulmonary Oedema: a Prospective Randomised Multicentre Trial. Completed NCT00446498 Phase 4
10 Randomised Controlled Comparison of Continuous Positive Airway Pressure (CPAP) With Standard Treatment in Out-of-hospital Patients With Acute Cardiogenic Pulmonary Edema. Completed NCT00439075 Phase 4 standard treatment
11 Non Invasive Positive Airway Pressure And Risk Of Myocardial Infarction In Acute Cardiogenic Pulmonary Edema: Continuous Positive Airway Pressure Vs Non Invasive Positive Pressure Ventilation Completed NCT00453947 Phase 4
12 Evaluating Fluid Strategies in Thoracic Surgery Patients Utilizing a Goal Directed Approach Completed NCT02135146 Phase 4 Plasmalyte 3ml/kg/hr group;Plasmalyte 6ml/kg/hr group
13 Randomized, Controlled Trial of Regular Sildenafil Citrate in the Prevention of Altitude Illness Completed NCT00627965 Phase 4 Sildenafil citrate;Placebo
14 Clarithromycin as Immunomodulatory Therapy for the Management of Septic Syndrome by Ventilator-Associated Pneumonia Completed NCT00297674 Phase 4 Intravenous Clarithromycin
15 Acetazolamide for the Prevention of High Altitude Illness: a Comparison of Dosing Completed NCT01993667 Phase 4 Low Dose Acetazolamide;Normal Dose Acetazolamide
16 Effect-site Concentration of Remifentanil for Smooth Removal of the Double-lumen Endotracheal Tube Completed NCT02528825 Phase 4 Remifentanil titration
17 The Effect of Riociguat on Gas Exchange, Exercise Performance, and Pulmonary Artery Pressure During Acute Altitude Exposure Completed NCT02024386 Phase 4 Riociguat
18 Impact of Aggressive Versus Standard Drainage Regimen Using a Long Term Indwelling Pleural Catheter on the Incidence of Auto-Pleurodesis in Patients With Malignant Pleural Effusions Completed NCT00978939 Phase 4
19 Short Term Physiological Effects of Nasal High Oxygen Flow vs Low Oxygen Flow and Noninvasive Ventilation (NIV) on Respiratory Mechanics Completed NCT02363920 Phase 4
20 Electromyographic Activity of the Diaphragm and of the Rectus Abdominis and Intercostal Muscles During Neostigmine, Sugammadex, or Neostigmine-sugammadex Enhanced Recovery After Neuromuscular Blockade With Rocuronium. A Randomised Controlled Study in Healthy Volunteers Completed NCT02403063 Phase 4 Sugammadex;Neostigmine;Neostigmine-sugammadex
21 Albumin vs. Plasma for PEdiAtric pRiming Trial Completed NCT02738190 Phase 4 Albumin
22 Effects Of A Recruitment Maneuver On Plasma Levels of sRAGE, The Soluble Form of The Receptor For Advanced Glycation End Products, In Patients With Diffuse Acute Respiratory Distress Syndrome (ARDS) Completed NCT01600651 Phase 4
23 Restrictive vs. Liberal Oxygen Therapy for Trauma Patients. PILOT: The TRAUMOX Trial Completed NCT03491644 Phase 4 Titrated Oxygen;Liberal Oxygen
24 Pheochromocytoma Randomised Study Comparing Adrenoreceptor Inhibiting Agents for Preoperative Treatment Completed NCT01379898 Phase 4 Phenoxybenzamine;Doxazosin
25 Perioperative Fluid Treatment in Colorectal Surgery Completed NCT03537989 Phase 4 Saline
26 Study Design and Rationale of "A Multicenter, Open-Labeled, Randomized Controlled Trial Comparing MIdazolam Versus MOrphine in Acute Pulmonary Edema": MIMO Trial Recruiting NCT02856698 Phase 4 Midazolam;Morphine
27 Impact of Obstructive Sleep Apnea Treatment on Cardiovascular Events in Patients With Acute Cardiogenic Pulmonary Edema: a Multicenter Randomized Controlled Study (CPAP-CARE STUDY). Recruiting NCT03936751 Phase 4
28 A Pragmatic Multicenter Randomized Clinical Trial (RCT) of Antihypertensive Therapy for Mild Chronic Hypertension During Pregnancy: Chronic Hypertension and Pregnancy (CHAP) Project Recruiting NCT02299414 Phase 4 Anti-hypertensive therapy
29 Impact of Early CRRT Intervention in Patients Receiving VA-ECMO Support on 30-day Mortality: A Randomized Controlled Trial Recruiting NCT03549923 Phase 4 Esmolol;Standard care
30 The Prognostic Impact of Using High-dose Hydralazine in Severe Systolic Heart Failure With Hemodynamically Significant Mitral Regurgitation Recruiting NCT04217135 Phase 4 evidence-based medications vs. high-dose hydralazine + evidence-based medications
31 Comparison of Milrinone Versus Dobutamine in a Heterogeneous Population of Critically Ill Patients Recruiting NCT03207165 Phase 4 Milrinone;Dobutamine
32 Effect of Non-steroidal Anti-inflammatory Use on Blood Pressure in Women With Hypertensive Disorders of Pregnancy: A Randomized Open Label Trial Recruiting NCT03824119 Phase 4 Ibuprofen 600 mg
33 Continued Versus Discontinued Oxytocin Stimulation of Labour in a Double-blind Randomised Controlled Trial Recruiting NCT02553226 Phase 4 Oxytocin;Placebo
34 A Prospective, Multi-Center, Randomized, Open Label Trial to Determine if a Common Atrial Fibrillation Risk Locus Modulates Differential Response to Antiarrhythmic Drugs Not yet recruiting NCT02347111 Phase 4 Flecainide;Sotalol
35 A Prospective, Double-blind, Randomized, Placebo-controlled Trial of Acetazolamide on Subclinical High-Altitude Pulmonary Edema Detected by Lung Ultrasonography Terminated NCT03490916 Phase 4 Acetazolamide;Placebo
36 Cardiovascular and Metabolic Physiological Adaptations to Intermittent Hypoxia. Physiological Aspects and Expression of Receptors and Cellular Mediators Terminated NCT02058823 Phase 4 Placebo;Placebo;Valsartan;Amlodipine
37 Does Maintenance of Normoglycemia Change Neurological Outcome in Patients Recovering From Traumatic Brain Injury and Subarachnoid or Intraparenchymal Hemorrhage? Terminated NCT01137773 Phase 4 Insulin;Conventional insulin treatment
38 Intravenous Isosorbide Dinitrate Versus Sublingual Isosorbide Dinitrate for the Relief of Acute Anginal Episodes in Acute Coronary Syndrome (ACS) Patients Withdrawn NCT00337116 Phase 4 iso sorbide dinitrate iv bolus or s/l
39 High-Dose Aldactone for Treatment of Diuretic Resistant Heart Failure Withdrawn NCT02429388 Phase 4 Spironolactone
40 Treatment of Asymptomatic Fluid Overload in Peritoneal Dialysis Patients Withdrawn NCT02168283 Phase 4
41 Double Blind Randomized Placebo Controlled Trial of Natrecor in Patients Hospitalized for Decompensated Heart Failure in the Presence of a Normal Left Ventricular Ejection Fraction Withdrawn NCT00505791 Phase 4 Nesiritide
42 Non Invasive Ventilation in Acute Asthma Unknown status NCT00510991 Phase 3
43 A Study to Evaluate the Effectiveness of Induced Diuresis With Matched Hydration Therapy Compared to Standard Overnight Hydration in the Prevention of Contrast Induced Nephropathy -MYTHOS Study Unknown status NCT00702728 Phase 3 Furosemide and matched saline hydration;isotonic saline solution
44 Bilevel Positive Pressure Ventilation (BIPAP)in Patients With Sleep Disorders Breathing (SDB)and Congestive Heart Failure (CHF):Comparison of Two Diagnostic Methods Unknown status NCT01501734 Phase 3
45 CPAP Boussignac Versus Bilevel Pressure Support Ventilation in Severe Acute Cardiogenic Pulmonary Edema Completed NCT00213681 Phase 3
46 Effect of Continuous Positive Airway Pressure as a First Line Therapy in Out-of-Hospital Management of Severe Cardiogenic Pulmonary Edema Completed NCT00390442 Phase 3
47 Effect of Continuous Positive Airway Pressure on Short Term Inhospital Prognosis for Acute Pulmonary Edema Completed NCT00554580 Phase 3
48 Non-Invasive Ventilation Versus Continuous Positive Airway Pressure in Cardiogenic Pulmonary Edema: a Multicentre Study Completed NCT00785174 Phase 3
49 Restrictive Versus Liberal Fresh Frozen Plasma Transfusion Prior to Low-Risk Invasive Procedures in Hospitalized Patients. Completed NCT00953901 Phase 3 Fresh Frozen Plasma Transfusion
50 Randomized Clinical Trial of the Beneficial Effects of Antenatal Magnesium Sulfate (BEAM) Completed NCT00014989 Phase 3 magnesium sulfate

Search NIH Clinical Center for Pulmonary Edema

Inferred drug relations via UMLS 71 / NDF-RT 50 :

Ethacrynate Sodium
Ethacrynic Acid
Mannitol hexanitrate

Cochrane evidence based reviews: pulmonary edema

Genetic Tests for Pulmonary Edema

Anatomical Context for Pulmonary Edema

MalaCards organs/tissues related to Pulmonary Edema:

Lung, Heart, Endothelial, Kidney, Brain, Liver, Neutrophil

Publications for Pulmonary Edema

Articles related to Pulmonary Edema:

(show top 50) (show all 14559)
# Title Authors PMID Year
Noninvasive Positive Pressure Ventilation for Acute Decompensated Heart Failure. 61
32503751 2020
Dobutamine in the treatment of severe scorpion envenoming. 61
32428515 2020
A loop-mediated isothermal amplification (LAMP) based assay for the rapid and sensitive group-specific detection of fumonisin producing Fusarium spp. 61
32334331 2020
Molecular Profiling of Vascular Remodeling in Chronic Pulmonary Disease. 61
32275906 2020
NEK7 mediated assembly and activation of NLRP3 inflammasome downstream of potassium efflux in ventilator-induced lung injury. 61
32353421 2020
Finally, a promising model for high-altitude pulmonary edema (HAPE)-A Mountaineers' Malady. 61
32243073 2020
Indications for non-invasive ventilation in respiratory failure. 61
32493199 2020
[Severe noncardiogenic pulmonary edema due to permeability disorder after i.v. administration of CT contrast medium with subsequent venovenous extracorporeal membrane oxygenation]. 61
32548721 2020
Unfractionated heparin inhibits histone-mediated coagulation activation and thrombosis in mice. 61
32559568 2020
Pulmonary Capillary Leak Syndrome following COVID-19 Virus Infection. 61
32519786 2020
COVID-19 Lung Injury is Not High Altitude Pulmonary Edema. 61
32281877 2020
Alveolar macrophage dysfunction and cytokine storm in the pathogenesis of two severe COVID-19 patients. 61
32574956 2020
Can mesenchymal stem cell therapy be the interim management of COVID-19? 61
32554953 2020
Letter to the Editor: COVID-19 Lung Injury Is Different From High Altitude Pulmonary Edema. 61
32364407 2020
Symmetric chest pressure ulcers, consequence of prone position ventilation in a patient with COVID-19. 61
32542928 2020
Impaired Breakdown of Bradykinin and Its Metabolites as a Possible Cause for Pulmonary Edema in COVID-19 Infection. 61
32526773 2020
A Clinical Study of Noninvasive Assessment of Lung Lesions in Patients with Coronavirus Disease-19 (COVID-19) by Bedside Ultrasound. 61
32294796 2020
Reactive species generated by heme impair alveolar epithelial sodium channel function in acute respiratory distress syndrome. 61
32506040 2020
Dexamethasone Upregulates the Expression of Aquaporin4 by Increasing SUMOylation in A549 Cells. 61
32495129 2020
How should we define appropriate patients for percutaneous transluminal renal angioplasty treatment? 61
32572170 2020
Novel drug delivery systems of β2 adrenoreceptor agonists to suppress SNCA gene expression and mitochondrial oxidative stress in Parkinson's disease management. 61
32497457 2020
Increased expression of microRNA-155-5p by alveolar type II cells contributes to development of lethal ARDS in H1N1 influenza A virus-infected mice. 61
32308197 2020
Complications following symptom limited thoracentesis using suction. 61
32499336 2020
Systems pharmacology reveals the mechanism of activity of Ge-Gen-Qin-Lian decoction against LPS-induced acute lung injury: A novel strategy for exploring active components and effective mechanism of TCM formulae. 61
32200026 2020
A Comprehensive Systemic Literature review of Pericardial Decompression Syndrome: Often Unrecognized and Potentially Fatal Syndrome. 61
32515313 2020
Lung Ultrasound Score Predicts the Extravascular Lung Water Content in Low-Birth-Weight Neonates with Patent Ductus Arteriosus. 61
32538377 2020
Non-ST elevation myocardial infarction induced by carbon monoxide poisoning. 61
32519987 2020
Acute respıratory dıstress syndrome(ARDS) after valproıc acıd toxıcıty ın the ıntensıve care unıt: Case report. 61
32525259 2020
The many faces and outcomes of pulmonary vein stenosis in early childhood. 61
32506838 2020
Early hours in the development of high-altitude pulmonary edema: time course and mechanisms. 61
32213112 2020
Robotic-assisted cardiac surgery without lung isolation utilizing single-lumen endotracheal tube intubation. 61
32353922 2020
Left Distal Radial Artery Access Site in Primary Percutaneous Coronary Intervention: Is It Safe? 61
32495613 2020
Polydeoxyribonucleotide ameliorates lipopolysaccharide-induced acute lung injury via modulation of the MAPK/NF-κB signaling pathway in rats. 61
32234670 2020
Right upper lobe pulmonary edema. 61
31713061 2020
[A very particular high altitude pulmonary edema]. 61
32506199 2020
[Unilateral Pulmonary Edema during Aortic Valve Replacement through Median Sternotomy]. 61
32475964 2020
A Review of Medical Problems in Himalayan Porters. 61
32311284 2020
Prevalence and Management of Severe Hand, Foot, and Mouth Disease in Xiangyang, China from 2008-2013. 61
32543714 2020
Effect of chest ultrasound on diagnostic workup in elderly patients with acute respiratory failure in the emergency department: a prospective study. 61
32568788 2020
Neurogenic pulmonary edema following febrile status epilepticus in a 22-month-old infant with multiple respiratory virus co-detection: a case report. 61
32487032 2020
High-Frequency Percussive Ventilation Rescue Therapy in Morbidly Obese Patients Failing Conventional Mechanical Ventilation. 61
29683055 2020
Acute Respiratory Distress Syndrome: Diagnosis and Management. 61
32538594 2020
Bite by a juvenile Bothrops venezuelensis (Venezuelan lancehead) resulting in severe envenomation: A case report. 61
32289355 2020
PCTR1 improves pulmonary edema fluid clearance through activating the sodium channel and lymphatic drainage in lipopolysaccharide-induced ARDS. 61
32529661 2020
Long Non-coding RNA LINC-PINT and LINC00599 Polymorphisms are Associated With High-altitude Pulmonary Edema in Chinese. 61
31761491 2020
Benefits of High-Flow Nasal Cannula Therapy for Acute Pulmonary Edema in Patients with Heart Failure in the Emergency Department: A Prospective Multi-Center Randomized Controlled Trial. 61
32575829 2020
Incidence of negative-pressure pulmonary edema following sugammadex administration during anesthesia emergence: A pilot audit of 27,498 general anesthesia patients and literature review. 61
31951917 2020
Renal artery intervention for a patient with flash pulmonary edema accompanied by elevation of troponin levels due to bilateral renal artery stenosis and multivessel coronary disease: a case report. 61
32495661 2020
Preventive Strategy for Reexpansion Pulmonary Edema After Minimally Invasive Cardiac Surgery. 61
31863755 2020
Left ventricular overloading identified by critical care echocardiography is key in weaning-induced pulmonary edema. 61
32377766 2020

Variations for Pulmonary Edema

Expression for Pulmonary Edema

Search GEO for disease gene expression data for Pulmonary Edema.

Pathways for Pulmonary Edema

Pathways related to Pulmonary Edema according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
3 12.81 KNG1 HMOX1 FGF7 F2 EDN1 CXCL8
Show member pathways
Show member pathways
Show member pathways
12.56 TNF NOS3 IL1B IL10 F2
Show member pathways
8 12.24 TNF IL1B F2 CXCL8
Show member pathways
12.24 TNF IL1B IL10 FGF7 CXCL8
Show member pathways
11 12.15 TNF IL1B IL10 CXCL8
12 11.99 TNF IL1B IL10 CXCL8
13 11.98 TNF IL1B ICAM1 CXCL8
14 11.93 TNF IL1B ICAM1 EDN1
15 11.89 TNF IL1B ICAM1 CXCL8
16 11.88 TNF IL1B IL10 CXCL8
17 11.86 TNF IL1B IL10 ICAM1 HMOX1 CXCL8
18 11.82 TNF IL1B ICAM1 CXCL8
19 11.75 TNF IL1B IL10
Show member pathways
22 11.71 TNF IL1B IL10
23 11.69 TNF IL1B IL10 CXCL8
24 11.68 REN EDN1 ACE
26 11.58 TNF IL1B CXCL8
Show member pathways
28 11.5 TNF KNG1 ICAM1
29 11.5 TNF IL1B IL10 ICAM1 CXCL8
30 11.46 TNF IL1B IL10 ICAM1 CXCL8
31 11.32 NOS3 HMOX1 CXCL8
32 11.3 TNF IL1B IL10 HMOX1
33 11.23 TNF IL1B IL10
34 11.13 IL1B ICAM1 F2
35 11.12 TNF KNG1 IL1B IL10 ICAM1
36 11.01 TNF HMOX1 CXCL8 CRP
38 10.87 TNF IL1B ICAM1

GO Terms for Pulmonary Edema

Cellular components related to Pulmonary Edema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 TNF SERPINC1 REN NPPB KNG1 IL1B
2 cell GO:0005623 9.76 TRPV4 TNNI3 NOS3 KNG1 ICAM1 HMOX1
3 extracellular space GO:0005615 9.47 TNF SERPINC1 REN NPPB KNG1 IL1B

Biological processes related to Pulmonary Edema according to GeneCards Suite gene sharing:

(show all 43)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.08 TRPV4 TNF NOS3 IL1B CRP
2 negative regulation of cell proliferation GO:0008285 10.06 NOS3 IL1B IL10 HMOX1 CXCL8
3 inflammatory response GO:0006954 10.03 TNF KNG1 IL1B CXCL8 CRP
4 leukocyte migration GO:0050900 9.95 TNF IL1B ICAM1 F2
5 positive regulation of angiogenesis GO:0045766 9.88 NOS3 IL1B HMOX1 CXCL8
6 neutrophil chemotaxis GO:0030593 9.86 IL1B EDN1 CXCL8
7 response to insulin GO:0032868 9.86 TRPV4 IL10 ICAM1
8 cellular response to drug GO:0035690 9.85 REN IL1B EDN1
9 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.83 TNF IL1B EDN1
10 positive regulation of smooth muscle cell proliferation GO:0048661 9.82 TNF HMOX1 EDN1
11 hemostasis GO:0007599 9.8 SERPINC1 KNG1 F2
12 positive regulation of DNA-binding transcription factor activity GO:0051091 9.8 TNF IL1B IL10 EDN1
13 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.78 TNF IL10 EDN1
14 cellular response to lipopolysaccharide GO:0071222 9.77 TNF IL1B IL10 ICAM1 CXCL8
15 positive regulation of interleukin-6 secretion GO:2000778 9.75 TRPV4 TNF IL1B
16 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.73 NOS3 ICAM1 HMOX1
17 cytokine-mediated signaling pathway GO:0019221 9.73 TNF IL1B IL10 ICAM1 HMOX1 CXCL8
18 lipopolysaccharide-mediated signaling pathway GO:0031663 9.72 TNF NOS3 IL1B
19 response to molecule of bacterial origin GO:0002237 9.69 IL10 CXCL8
20 positive regulation of JAK-STAT cascade GO:0046427 9.69 TNF IL10 F2
21 negative regulation of lipid storage GO:0010888 9.68 TNF CRP
22 negative regulation of platelet activation GO:0010544 9.68 NOS3 F2
23 body fluid secretion GO:0007589 9.67 NPPB EDN1
24 regulation of establishment of endothelial barrier GO:1903140 9.66 TNF IL1B
25 endothelial cell apoptotic process GO:0072577 9.66 TNF IL10
26 acute inflammatory response to antigenic stimulus GO:0002438 9.65 SERPINC1 ICAM1
27 cellular hypotonic response GO:0071476 9.64 TRPV4 AQP5
28 positive regulation of prostaglandin secretion GO:0032308 9.63 IL1B EDN1
29 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.62 NOS3 EDN1
30 negative regulation of cytokine production involved in immune response GO:0002719 9.61 TNF IL10
31 regulation of blood vessel diameter GO:0097746 9.61 NPPB NOS3 ACE
32 positive regulation of fever generation GO:0031622 9.6 TNF IL1B
33 negative regulation of cytokine secretion involved in immune response GO:0002740 9.59 TNF IL10
34 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.58 TNF IL1B IL10
35 sequestering of triglyceride GO:0030730 9.57 TNF IL1B
36 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.54 TNF IL1B
37 receptor biosynthetic process GO:0032800 9.52 TNF IL10
38 positive regulation of chemokine biosynthetic process GO:0045080 9.5 TNF IL1B HMOX1
39 negative regulation of gap junction assembly GO:1903597 9.48 IL1B ACE
40 smooth muscle hyperplasia GO:0014806 9.46 NOS3 HMOX1
41 positive regulation of nitric oxide biosynthetic process GO:0045429 9.46 TNF IL1B ICAM1 EDN1
42 response to lipopolysaccharide GO:0032496 9.43 REN NOS3 IL1B IL10 ICAM1 EDN1
43 regulation of blood pressure GO:0008217 9.1 REN NPPB NOS3 HMOX1 EDN1 ACE

Molecular functions related to Pulmonary Edema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.21 TRPV4 TNNI3 TNF SERPINC1 REN NPPB
2 signaling receptor binding GO:0005102 9.55 REN NPPB KNG1 F2 EDN1
3 heparin binding GO:0008201 9.26 SERPINC1 KNG1 FGF7 F2
4 cytokine activity GO:0005125 9.02 TNF IL1B IL10 EDN1 CXCL8

Sources for Pulmonary Edema

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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