MCID: PLM010
MIFTS: 56

Pulmonary Edema

Categories: Cardiovascular diseases, Respiratory diseases

Aliases & Classifications for Pulmonary Edema

MalaCards integrated aliases for Pulmonary Edema:

Name: Pulmonary Edema 12 44 15 17 72

Classifications:



External Ids:

Disease Ontology 12 DOID:11396
MeSH 44 D011654
NCIt 50 C26868
SNOMED-CT 68 19242006
ICD10 33 J81 J81.1
UMLS 72 C0034063

Summaries for Pulmonary Edema

MalaCards based summary : Pulmonary Edema is related to acute mountain sickness and acute respiratory distress syndrome, and has symptoms including edema, hemoptysis and peau d'orange. An important gene associated with Pulmonary Edema is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Immune response IL-23 signaling pathway. The drugs Midazolam and Simvastatin have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and endothelial, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 75 Pulmonary edema is fluid accumulation in the tissue and air spaces of the lungs. It leads to impaired... more...

Related Diseases for Pulmonary Edema

Diseases related to Pulmonary Edema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 761)
# Related Disease Score Top Affiliating Genes
1 acute mountain sickness 33.9 PIK3C2A NOS3 EDN1 ACE
2 acute respiratory distress syndrome 33.6 TNF IL1B CXCL8
3 chronic mountain sickness 33.2 NPPB NOS3 EDN1
4 adult respiratory distress syndrome 32.6 TNF IL10 F2 CXCL8 ACE
5 silicosis 32.3 TNF IL1B CXCL8 ACE
6 congestive heart failure 31.6 REN NPPB EDN1 ACE
7 pulmonary hypertension 31.4 REN NPPB NOS3 EDN1 ACE
8 cardiogenic shock 31.3 TNF PIK3C2A NPPB
9 mitral valve disease 31.1 NOS3 IL10 ACE
10 diastolic heart failure 31.0 NPPB NOS3 ACE
11 aortic coarctation 31.0 NOS3 EDN1 ACE
12 idiopathic interstitial pneumonia 30.8 ICAM1 EDN1 CXCL8
13 toxic shock syndrome 30.8 TNF IL1B IL10 CXCL8
14 respiratory failure 30.7 TNF PIK3C2A CXCL8 CRP ACE
15 ischemia 30.6 NOS3 ICAM1 HMOX1 EDN1 ACE
16 rheumatic heart disease 30.6 TNF IL10 ACE
17 renal artery disease 30.6 REN NOS3 ACE
18 myocarditis 30.6 TNNI3 TNF NPPB ICAM1
19 poliomyelitis 30.6 TNF IL10 ICAM1
20 left bundle branch hemiblock 30.5 TNNI3 NPPB ACE
21 coronary artery vasospasm 30.5 PIK3C2A NOS3 EDN1
22 anuria 30.4 REN PIK3C2A ACE
23 bronchiolitis obliterans 30.4 TNF IL10 CXCL8
24 end stage renal failure 30.4 TNF CRP ACE
25 atrial standstill 1 30.4 TNNI3 NPPB ACE
26 plasmodium falciparum malaria 30.4 TNF IL10 ICAM1
27 malignant hypertension 30.4 REN EDN1 ACE
28 connective tissue disease 30.4 TNF IL10 EDN1 ACE
29 intracranial hypertension 30.3 TNF IL1B F2
30 cardiac tamponade 30.3 REN NPPB F2
31 heart valve disease 30.3 REN NPPB CRP ACE
32 staphylococcal toxic shock syndrome 30.3 TNF IL1B
33 mouth disease 30.3 TNF IL1B IL10 CRP
34 tonsillitis 30.2 TNF IL1B CXCL8
35 pneumoconiosis 30.2 TNF IL1B CXCL8
36 extrinsic allergic alveolitis 30.2 IL1B IL10 CXCL8
37 duodenal ulcer 30.2 TNF IL1B CXCL8
38 eclampsia 30.2 TNF REN F2 EDN1
39 plasmodium vivax malaria 30.1 TNF IL10 ICAM1
40 coronary heart disease 1 30.1 NPPB NOS3 CRP ACE
41 renovascular hypertension 30.1 REN NOS3 HMOX1 EDN1 ACE
42 interstitial lung disease 30.1 TNF IL1B IL10 EDN1 CXCL8
43 graft-versus-host disease 30.0 TNF IL1B IL10
44 carotid stenosis 30.0 TNF CRP ACE
45 aseptic meningitis 30.0 TNF IL1B IL10 CXCL8
46 colitis 30.0 TNF IL1B IL10 CXCL8
47 hemorrhagic fever with renal syndrome 30.0 TNF CXCL8 CRP
48 acquired immunodeficiency syndrome 30.0 TNF IL1B IL10
49 bronchiolitis 29.9 TNF IL10 CXCL8 CRP
50 pericarditis 29.9 TNF NPPB IL1B CRP

Graphical network of the top 20 diseases related to Pulmonary Edema:



Diseases related to Pulmonary Edema

Symptoms & Phenotypes for Pulmonary Edema

UMLS symptoms related to Pulmonary Edema:


edema, hemoptysis, peau d'orange

GenomeRNAi Phenotypes related to Pulmonary Edema according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.92 ACE CFTR CXCL8 F2 HMOX1 ICAM1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.92 ACE CFTR CXCL8 F2 HMOX1 ICAM1

MGI Mouse Phenotypes related to Pulmonary Edema:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.38 ACE CRP EDN1 F2 HMOX1 ICAM1
2 homeostasis/metabolism MP:0005376 10.36 ACE AQP5 CFTR CRP EDN1 F2
3 growth/size/body region MP:0005378 10.34 ACE AQP5 CFTR EDN1 F2 FGF7
4 behavior/neurological MP:0005386 10.33 ACE AQP5 CFTR F2 FGF7 HMOX1
5 hematopoietic system MP:0005397 10.26 ACE CFTR F2 FGF7 HMOX1 ICAM1
6 immune system MP:0005387 10.25 ACE CFTR CRP F2 FGF7 HMOX1
7 mortality/aging MP:0010768 10.25 ACE AQP5 CFTR EDN1 F2 HMOX1
8 endocrine/exocrine gland MP:0005379 10.16 ACE AQP5 CFTR EDN1 HMOX1 ICAM1
9 digestive/alimentary MP:0005381 10.13 AQP5 CFTR EDN1 F2 ICAM1 IL10
10 muscle MP:0005369 10.07 AQP5 EDN1 HMOX1 ICAM1 IL10 NOS3
11 nervous system MP:0003631 10.02 EDN1 F2 FGF7 ICAM1 IL10 IL1B
12 renal/urinary system MP:0005367 9.86 ACE EDN1 FGF7 HMOX1 NOS3 PIK3C2A
13 reproductive system MP:0005389 9.81 ACE CFTR F2 FGF7 HMOX1 IL10
14 respiratory system MP:0005388 9.61 AQP5 CFTR F2 HMOX1 IL10 NOS3
15 vision/eye MP:0005391 9.23 AQP5 CFTR FGF7 ICAM1 IL10 NOS3

Drugs & Therapeutics for Pulmonary Edema

Drugs for Pulmonary Edema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 276)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
2
Simvastatin Approved Phase 4 79902-63-9 54454
3
Clarithromycin Approved Phase 4 81103-11-9 84029
4
Remifentanil Approved Phase 4 132875-61-7 60815
5
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
6
Riociguat Approved Phase 4 625115-55-1
7
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
8
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
9
Phenoxybenzamine Approved Phase 4 59-96-1 4768
10
Doxazosin Approved Phase 4 74191-85-8 3157
11
Dobutamine Approved Phase 4 34368-04-2 36811
12
Ibuprofen Approved Phase 4 15687-27-1 3672
13
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
14
Oxytocin Approved, Vet_approved Phase 4 50-56-6 439302 53477758
15
Nifedipine Approved Phase 4 21829-25-4 4485
16
Labetalol Approved Phase 4 36894-69-6 3869
17
Azithromycin Approved Phase 4 83905-01-5 447043 55185
18
Esmolol Approved Phase 4 103598-03-4, 81147-92-4 59768
19
Acetaminophen Approved Phase 4 103-90-2 1983
20
Milrinone Approved Phase 4 78415-72-2 4197
21
Sotalol Approved Phase 4 959-24-0, 3930-20-9 5253
22
Lisinopril Approved, Investigational Phase 4 83915-83-7, 76547-98-3 5362119
23
Acetazolamide Approved, Vet_approved Phase 4 59-66-5 1986
24
tannic acid Approved Phase 4 1401-55-4
25
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
26
Zinc Approved, Investigational Phase 4 7440-66-6 32051
27
Amlodipine Approved Phase 4 88150-42-9 2162
28
Angiotensin II Approved, Investigational Phase 4 11128-99-7, 68521-88-0, 4474-91-3 172198
29
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
30
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
31 Tranquilizing Agents Phase 4
32 Anti-Anxiety Agents Phase 4
33 GABA Agents Phase 4
34 Adjuvants, Anesthesia Phase 4
35 GABA Modulators Phase 4
36 Psychotropic Drugs Phase 4
37 Anesthetics, Intravenous Phase 4
38 Rosuvastatin Calcium Phase 4 147098-20-2
39 Analgesics, Opioid Phase 4
40 Ophthalmic Solutions Phase 4
41 Plasma-lyte 148 Phase 4
42 Chelating Agents Phase 4
43 Cytochrome P-450 CYP3A Inhibitors Phase 4
44 Cytochrome P-450 Enzyme Inhibitors Phase 4
45 Anti-Bacterial Agents Phase 4
46 Antibiotics, Antitubercular Phase 4
47 Performance-Enhancing Substances Phase 4
48 Neuromuscular Nondepolarizing Agents Phase 4
49
Glycopyrrolate Phase 4 596-51-0 3494
50 Cholinergic Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 373)
# Name Status NCT ID Phase Drugs
1 Study Design and Rationale of "A Multicenter, Open-Labeled, Randomized Controlled Trial Comparing MIdazolam Versus MOrphine in Acute Pulmonary Edema": MIMO Trial Unknown status NCT02856698 Phase 4 Midazolam;Morphine
2 Impact of Fluid Resuscitation Therapy on Pulmonary Edema as Measured by Alveolar Fluid Clearance in Patients With Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT01763853 Phase 4 4% albumin
3 Non-Invasive Positive Pressure Mask Ventilation vs Extrathoracic Biphasic Cuirass Ventilation in Patients With Acute Respiratory Failure: A Randomized Prospective Study. Unknown status NCT00331656 Phase 4
4 Remifentanil for c-Section With General Anesthesia in Severe Preeclamptic Patients Unknown status NCT00567957 Phase 4 Remifentanil;Saline
5 MICROS-Pilot Study Microcirculation In Acute Coronary Syndromes; Effect of Pre-treatment of High Dose Rosuvastatin on Coronary Microcirculation in Primary PCI Unknown status NCT01382472 Phase 4 Rosuvastatin;Simvastatin
6 Effects of Atorvastatin Treatment on Left Ventricular Diastolic Function in Peritoneal Dialysis Patients (ALEVENT) Unknown status NCT01503671 Phase 4 Atorvastatin
7 CPAP Versus BiPAP in Acute Cardiogenic Pulmonary Edema: Experience With 129 Patients Completed NCT00912158 Phase 4
8 Continuous Positive Airway Pressure Versus Non-Invasive Positive Pressure Support Ventilation in Acute Cardiogenic Pulmonary Oedema: a Prospective Randomised Multicentre Trial. Completed NCT00446498 Phase 4
9 Randomised Controlled Comparison of Continuous Positive Airway Pressure (CPAP) With Standard Treatment in Out-of-hospital Patients With Acute Cardiogenic Pulmonary Edema. Completed NCT00439075 Phase 4 standard treatment
10 Non Invasive Positive Airway Pressure And Risk Of Myocardial Infarction In Acute Cardiogenic Pulmonary Edema: Continuous Positive Airway Pressure Vs Non Invasive Positive Pressure Ventilation Completed NCT00453947 Phase 4
11 Evaluating Fluid Strategies in Thoracic Surgery Patients Utilizing a Goal Directed Approach Completed NCT02135146 Phase 4 Plasmalyte 3ml/kg/hr group;Plasmalyte 6ml/kg/hr group
12 Randomized, Controlled Trial of Regular Sildenafil Citrate in the Prevention of Altitude Illness Completed NCT00627965 Phase 4 Sildenafil citrate;Placebo
13 Clarithromycin as Immunomodulatory Therapy for the Management of Septic Syndrome by Ventilator-Associated Pneumonia Completed NCT00297674 Phase 4 Intravenous Clarithromycin
14 Acetazolamide for the Prevention of High Altitude Illness: a Comparison of Dosing Completed NCT01993667 Phase 4 Low Dose Acetazolamide;Normal Dose Acetazolamide
15 Effect-site Concentration of Remifentanil for Smooth Removal of the Double-lumen Endotracheal Tube Completed NCT02528825 Phase 4 Remifentanil titration
16 The Effect of Riociguat on Gas Exchange, Exercise Performance, and Pulmonary Artery Pressure During Acute Altitude Exposure Completed NCT02024386 Phase 4 Riociguat
17 Impact of Aggressive Versus Standard Drainage Regimen Using a Long Term Indwelling Pleural Catheter on the Incidence of Auto-Pleurodesis in Patients With Malignant Pleural Effusions Completed NCT00978939 Phase 4
18 Electromyographic Activity of the Diaphragm and of the Rectus Abdominis and Intercostal Muscles During Neostigmine, Sugammadex, or Neostigmine-sugammadex Enhanced Recovery After Neuromuscular Blockade With Rocuronium. A Randomised Controlled Study in Healthy Volunteers Completed NCT02403063 Phase 4 Sugammadex;Neostigmine;Neostigmine-sugammadex
19 Short Term Physiological Effects of Nasal High Oxygen Flow vs Low Oxygen Flow and Noninvasive Ventilation (NIV) on Respiratory Mechanics Completed NCT02363920 Phase 4
20 Albumin vs. Plasma for PEdiAtric pRiming Trial Completed NCT02738190 Phase 4 Albumin
21 Effects Of A Recruitment Maneuver On Plasma Levels of sRAGE, The Soluble Form of The Receptor For Advanced Glycation End Products, In Patients With Diffuse Acute Respiratory Distress Syndrome (ARDS) Completed NCT01600651 Phase 4
22 Restrictive vs. Liberal Oxygen Therapy for Trauma Patients. PILOT: The TRAUMOX Trial Completed NCT03491644 Phase 4 Titrated Oxygen;Liberal Oxygen
23 Pheochromocytoma Randomised Study Comparing Adrenoreceptor Inhibiting Agents for Preoperative Treatment Completed NCT01379898 Phase 4 Phenoxybenzamine;Doxazosin
24 Perioperative Fluid Treatment in Colorectal Surgery Completed NCT03537989 Phase 4 Saline
25 Impact of Obstructive Sleep Apnea Treatment on Cardiovascular Events in Patients With Acute Cardiogenic Pulmonary Edema: a Multicenter Randomized Controlled Study (CPAP-CARE STUDY). Recruiting NCT03936751 Phase 4
26 A Pragmatic Multicenter Randomized Clinical Trial (RCT) of Antihypertensive Therapy for Mild Chronic Hypertension During Pregnancy: Chronic Hypertension and Pregnancy (CHAP) Project Recruiting NCT02299414 Phase 4 Anti-hypertensive therapy
27 Impact of Antichlamydial Treatment on the Rate of Preeclampsia Among Egyptian Primigravidae: a Randomized Controlled Trial Recruiting NCT03233880 Phase 4 Azithromycin 1gm
28 Impact of Early CRRT or Beta-blocker Intervention in Patients Receiving VA-ECMO Support on 30-day Mortality: A 2 × 2 Partial Factorial Randomized Controlled Trial Recruiting NCT03549923 Phase 4 Esmolol;Standard care
29 Effect of Non-steroidal Anti-inflammatory Use on Blood Pressure in Women With Hypertensive Disorders of Pregnancy: A Randomized Open Label Trial Recruiting NCT03824119 Phase 4 Ibuprofen 600 mg
30 Comparison of Milrinone Versus Dobutamine in a Heterogeneous Population of Critically Ill Patients Recruiting NCT03207165 Phase 4 Milrinone;Dobutamine
31 Continued Versus Discontinued Oxytocin Stimulation of Labour in a Double-blind Randomised Controlled Trial Recruiting NCT02553226 Phase 4 Oxytocin;Placebo
32 A Pilot and Feasibility Study to Determine if a Common Atrial Fibrillation Risk Locus Modulates Differential Response to Antiarrhythmic Drugs Recruiting NCT02347111 Phase 4 Flecainide;Sotalol
33 Prophylactic Lisinopril to Prevent Anthracycline Induced Left Ventricular Systolic Dysfunction (PLAID) Study. Not yet recruiting NCT03392740 Phase 4 Lisinopril;Placebo Oral Tablet
34 A Prospective, Double-blind, Randomized, Placebo-controlled Trial of Acetazolamide on Subclinical High-Altitude Pulmonary Edema Detected by Lung Ultrasonography Terminated NCT03490916 Phase 4 Acetazolamide;Placebo
35 Does Maintenance of Normoglycemia Change Neurological Outcome in Patients Recovering From Traumatic Brain Injury and Subarachnoid or Intraparenchymal Hemorrhage? Terminated NCT01137773 Phase 4 Insulin;Conventional insulin treatment
36 Cardiovascular and Metabolic Physiological Adaptations to Intermittent Hypoxia. Physiological Aspects and Expression of Receptors and Cellular Mediators Terminated NCT02058823 Phase 4 Placebo;Placebo;Valsartan;Amlodipine
37 Intravenous Isosorbide Dinitrate Versus Sublingual Isosorbide Dinitrate for the Relief of Acute Anginal Episodes in Acute Coronary Syndrome (ACS) Patients Withdrawn NCT00337116 Phase 4 iso sorbide dinitrate iv bolus or s/l
38 High-Dose Aldactone for Treatment of Diuretic Resistant Heart Failure Withdrawn NCT02429388 Phase 4 Spironolactone
39 Treatment of Asymptomatic Fluid Overload in Peritoneal Dialysis Patients Withdrawn NCT02168283 Phase 4
40 Double Blind Randomized Placebo Controlled Trial of Natrecor in Patients Hospitalized for Decompensated Heart Failure in the Presence of a Normal Left Ventricular Ejection Fraction Withdrawn NCT00505791 Phase 4 Nesiritide
41 Non Invasive Ventilation in Acute Asthma Unknown status NCT00510991 Phase 3
42 Bilevel Positive Pressure Ventilation (BIPAP)in Patients With Sleep Disorders Breathing (SDB)and Congestive Heart Failure (CHF):Comparison of Two Diagnostic Methods Unknown status NCT01501734 Phase 3
43 A Study to Evaluate the Effectiveness of Induced Diuresis With Matched Hydration Therapy Compared to Standard Overnight Hydration in the Prevention of Contrast Induced Nephropathy -MYTHOS Study Unknown status NCT00702728 Phase 3 Furosemide and matched saline hydration;isotonic saline solution
44 CPAP Boussignac Versus Bilevel Pressure Support Ventilation in Severe Acute Cardiogenic Pulmonary Edema Completed NCT00213681 Phase 3
45 Effect of Continuous Positive Airway Pressure as a First Line Therapy in Out-of-Hospital Management of Severe Cardiogenic Pulmonary Edema Completed NCT00390442 Phase 3
46 Effect of Continuous Positive Airway Pressure on Short Term Inhospital Prognosis for Acute Pulmonary Edema Completed NCT00554580 Phase 3
47 Non-Invasive Ventilation Versus Continuous Positive Airway Pressure in Cardiogenic Pulmonary Edema: a Multicentre Study Completed NCT00785174 Phase 3
48 Restrictive Versus Liberal Fresh Frozen Plasma Transfusion Prior to Low-Risk Invasive Procedures in Hospitalized Patients. Completed NCT00953901 Phase 3 Fresh Frozen Plasma Transfusion
49 Randomized Clinical Trial of the Beneficial Effects of Antenatal Magnesium Sulfate (BEAM) Completed NCT00014989 Phase 3 magnesium sulfate
50 Restricted Intravenous Fluid Regime Effects on Immunological Indicators of Elderly Patients Operated for Abdominal Cancer Completed NCT01399814 Phase 3

Search NIH Clinical Center for Pulmonary Edema

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Bumetanide
Ethacrynate Sodium
Ethacrynic Acid
Furosemide
Mannitol hexanitrate
Nifedipine
torsemide

Cochrane evidence based reviews: pulmonary edema

Genetic Tests for Pulmonary Edema

Anatomical Context for Pulmonary Edema

MalaCards organs/tissues related to Pulmonary Edema:

41
Lung, Heart, Endothelial, Kidney, Brain, Liver, Neutrophil

Publications for Pulmonary Edema

Articles related to Pulmonary Edema:

(show top 50) (show all 14144)
# Title Authors PMID Year
1
Pre-clinical assessment of a water-in-fluorocarbon emulsion for the treatment of pulmonary vascular diseases. 38
30822171 2019
2
Ursodeoxycholic acid stimulates alveolar fluid clearance in LPS-induced pulmonary edema via ALX/cAMP/PI3K pathway. 38
30972764 2019
3
Phosphodiesterase-4 Inhibitor Roflumilast Attenuates Pulmonary Air Emboli-Induced Lung Injury. 38
31004869 2019
4
Major Cardiac Events in Patients Admitted to Intensive Care After Vascular Noncardiac Surgery: A Retrospective Cohort. 38
30678531 2019
5
Scorpion envenomation and inflammation: Beyond neurotoxic effects. 38
31228480 2019
6
Medical and pathologic characteristics of fatal anaphylaxis: a Spanish nationwide 17-year series. 38
31292823 2019
7
Lung ultrasonography findings in dogs with various underlying causes of cough. 38
31429645 2019
8
Ablation of endothelial Pfkfb3 protects mice from acute lung injury in LPS-induced endotoxemia. 38
31167111 2019
9
Swiss Mountain Guides: Medical Education, Knowledge, and Practice. 38
31373841 2019
10
miR-144-mediated Inhibition of ROCK1 Protects against LPS-induced Lung Endothelial Hyperpermeability. 38
30811958 2019
11
Targeting Notch-activated M1 macrophages attenuate lung tissue damage in a rat model of ventilator induced lung injury. 38
31432103 2019
12
Ulinastatin ameliorates LPS‑induced pulmonary inflammation and injury by blocking the MAPK/NF‑κB signaling pathways in rats. 38
31432172 2019
13
Aquaporin 4 Blockade Attenuates Acute Lung Injury Through Inhibition of Th17 Cell Proliferation in Mice. 38
30945038 2019
14
Pharmacokinetics of thiotepa in high-dose regimens for autologous hematopoietic stem cell transplant in Japanese patients with pediatric tumors or adult lymphoma. 38
31428821 2019
15
Clinical Pearls of Venoarterial Extracorporeal Membrane Oxygenation for Cardiogenic Shock. 38
31364329 2019
16
Handling shock in idiopathic systemic capillary leak syndrome (Clarkson's disease): less is more. 38
31154613 2019
17
Phage Therapy of Pneumonia Is Not Associated with an Overstimulation of the Inflammatory Response Compared to Antibiotic Treatment in Mice. 38
31182526 2019
18
Maternal Age and Preeclampsia Outcomes during Delivery Hospitalizations. 38
31430824 2019
19
Is immunosuppression status a risk factor for noninvasive ventilation failure in patients with acute hypoxemic respiratory failure? A post hoc matched analysis. 38
31414246 2019
20
Management of fluid status and cardiovascular function in patients with diffuse skin inflammation. 38
30252553 2019
21
Discovery of GSK2798745: A Clinical Candidate for Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4). 38
31413810 2019
22
Hematopoietic stem cell mobilization following PD-1 blockade: Cytokine release syndrome after transplantation managed with ascorbic acid. 38
31140644 2019
23
Thoracic ultrasonography: a narrative review. 38
31418060 2019
24
Hyperacute Graft Dysfunction in an Orthotopic Heart Transplant In the Presence of Non-HLA Antibodies. 38
31400258 2019
25
Treating murine inflammatory diseases with an anti-erythrocyte antibody. 38
31434758 2019
26
VEGF mediates fat embolism-induced acute lung injury via VEGF receptor 2 and the MAPK cascade. 38
31406128 2019
27
Astragalin reduces lipopolysaccharide-induced acute lung injury in rats via induction of heme oxygenase-1. 38
31250343 2019
28
[Use of lung and pleural ultrasonography in emergency and intensive care medicine]. 38
31392352 2019
29
Incidence and Consequence of Nontarget Embolization Following Bland Hepatic Arterial Embolization. 38
31073823 2019
30
Assessment of the German and Italian Stress Cardiomyopathy Score for Risk Stratification for In-hospital Complications in Patients With Takotsubo Syndrome. 38
31389988 2019
31
Induced pluripotent stem cell-derived endothelial cells attenuate lipopolysaccharide-induced acute lung injury. 38
31295064 2019
32
Human unrestricted somatic stem cells ameliorate sepsis-related acute lung injury in mice. 38
30624762 2019
33
Noninvasive Ventilation in Acute Heart Failure. 38
31147960 2019
34
MCP-1 promotes detrimental cardiac physiology, pulmonary edema, and death in the cpk model of polycystic kidney disease. 38
31091126 2019
35
Balloon pulmonary angioplasty vs riociguat in patients with inoperable chronic thromboembolic pulmonary hypertension: A systematic review and meta-analysis. 38
31188483 2019
36
Acute pulmonary and splenic response in an in vivo model of whole-body low-dose X-radiation exposure. 38
31140892 2019
37
Negative-pressure pulmonary edema after laparoscopic appendectomy. 38
31348098 2019
38
Operative Hysteroscopy Intravascular Absorption Syndrome Causing Hyponatremia with Associated Cerebral and Pulmonary Edema. 38
31404167 2019
39
Morphine Use in the Treatment of Acute Cardiogenic Pulmonary Edema and Its Effects on Patient Outcome: A Systematic Review. 38
31183779 2019
40
Heavy upright exercise increases ventilation-perfusion mismatch in the basal lung: indirect evidence for interstitial pulmonary edema. 38
31246558 2019
41
Anti-inflammatory and antiviral effects of minocycline in enterovirus 71 infections. 38
31377467 2019
42
Immunomodulatory and Anti-Inflammatory Potential of Curcumin for the Treatment of Allergic Asthma: Effects on Expression Levels of Pro-inflammatory Cytokines and Aquaporins. 38
31407145 2019
43
Cardiogenic pulmonary edema: mechanisms and treatment - an intensivist's view. 38
31116110 2019
44
Preoperative Left Ventricular Diastolic Dysfunction Is Associated with Pulmonary Edema after Carotid Endarterectomy. 38
31105129 2019
45
Predictors for Mortality in Children with Scorpion Envenomation Admitted to Pediatric Intensive Care Unit, Qena Governorate, Egypt. 38
31407657 2019
46
A consensus redefinition of transfusion-related acute lung injury. 38
30993745 2019
47
Activation of death-associated protein kinase 1 promotes neutrophil apoptosis to accelerate inflammatory resolution in acute respiratory distress syndrome. 38
30911150 2019
48
Safety and complications of medical thoracoscopy in the management of pleural diseases. 38
31291926 2019
49
Fraxin Alleviates LPS-Induced ARDS by Downregulating Inflammatory Responses and Oxidative Damages and Reducing Pulmonary Vascular Permeability. 38
31273573 2019
50
A Randomized Controlled Trial of Naloxone for Optimization of Hypoxemia in Lung Donors After Brain Death. 38
30399122 2019

Variations for Pulmonary Edema

Expression for Pulmonary Edema

Search GEO for disease gene expression data for Pulmonary Edema.

Pathways for Pulmonary Edema

Pathways related to Pulmonary Edema according to GeneCards Suite gene sharing:

(show all 39)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.31 TNF IL1B IL10 ICAM1 HMOX1 FGF7
2
Show member pathways
12.54 TNF NOS3 IL1B IL10 F2
3
Show member pathways
12.43 NOS3 HMOX1 CXCL8 CFTR
4
Show member pathways
12.28 TNF IL1B CXCL8 CFTR
5
Show member pathways
12.27 TNF IL1B ICAM1 F2 CRP
6
Show member pathways
12.22 TNF IL1B IL10 FGF7 CXCL8
7
Show member pathways
12.16 TNF IL1B HMOX1 EDN1 CXCL8 CFTR
8
Show member pathways
12.15 TNF IL1B CXCL8 CFTR
9 12.14 TNF IL1B IL10 CXCL8
10
Show member pathways
12.03 IL1B IL10 ICAM1 FGF7 CXCL8
11 11.98 TNF IL1B ICAM1 CXCL8
12 11.93 TNF IL1B ICAM1 EDN1
13 11.88 TNF IL1B IL10 CXCL8
14 11.87 TNF IL1B ICAM1 CXCL8
15
Show member pathways
11.82 ICAM1 CXCL8 CFTR
16 11.82 TNF IL1B ICAM1 CXCL8
17 11.79 REN NOS3 HMOX1
18 11.79 TNF IL1B IL10 ICAM1 HMOX1 CXCL8
19 11.74 TNF IL1B IL10
20 11.71 TNF IL1B IL10 CXCL8
21 11.7 TNF IL1B IL10
22 11.68 TNF IL1B IL10
23 11.64 TRPV4 TNF NOS3 IL1B ICAM1 HMOX1
24 11.63 TNF NOS3 IL1B ICAM1 EDN1 CXCL8
25
Show member pathways
11.6 TNF IL1B ICAM1 CXCL8
26 11.56 TNF IL1B CXCL8
27 11.46 TNF IL1B IL10 ICAM1 CXCL8
28 11.41 TNF IL1B IL10 ICAM1 CXCL8
29 11.33 TNF IL1B IL10 ICAM1
30 11.32 TNF IL1B IL10 HMOX1
31 11.31 NOS3 HMOX1 CXCL8
32 11.23 TNF IL1B IL10
33 11.17 TNF IL1B IL10 CXCL8
34 11.15 IL1B ICAM1 F2
35 10.98 TNF HMOX1 CXCL8 CRP
36 10.97 TNF IL1B IL10 FGF7 CXCL8
37 10.9 TNF IL1B HMOX1 FGF7 EDN1 CXCL8
38 10.89 TNF IL1B ICAM1
39 10.79 NOS3 CFTR

GO Terms for Pulmonary Edema

Cellular components related to Pulmonary Edema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 TNF REN NPPB IL1B IL10 FGF7
2 extracellular space GO:0005615 9.4 TNF REN NPPB IL1B IL10 ICAM1

Biological processes related to Pulmonary Edema according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Name GO ID Score Top Affiliating Genes
1 response to organic substance GO:0010033 9.89 TNF REN IL10
2 positive regulation of JNK cascade GO:0046330 9.88 TRPV4 TNF IL1B
3 neutrophil chemotaxis GO:0030593 9.88 IL1B EDN1 CXCL8
4 cellular response to interleukin-1 GO:0071347 9.88 ICAM1 EDN1 CXCL8
5 positive regulation of angiogenesis GO:0045766 9.88 NOS3 IL1B HMOX1 CXCL8
6 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.87 TRPV4 TNF ICAM1
7 response to insulin GO:0032868 9.87 TRPV4 IL10 ICAM1
8 response to drug GO:0042493 9.86 REN IL10 ICAM1 EDN1
9 cellular response to drug GO:0035690 9.85 REN IL1B EDN1
10 positive regulation of smooth muscle cell proliferation GO:0048661 9.83 TNF HMOX1 EDN1
11 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.8 TNF IL1B EDN1
12 response to hypoxia GO:0001666 9.8 ICAM1 HMOX1 EDN1
13 positive regulation of DNA-binding transcription factor activity GO:0051091 9.8 TNF IL1B IL10 EDN1
14 cytokine-mediated signaling pathway GO:0019221 9.8 TNF IL1B IL10 ICAM1 HMOX1 CXCL8
15 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.77 TNF IL10 EDN1
16 cellular response to lipopolysaccharide GO:0071222 9.77 TNF IL1B IL10 ICAM1 CXCL8
17 lipopolysaccharide-mediated signaling pathway GO:0031663 9.72 TNF NOS3 IL1B
18 response to molecule of bacterial origin GO:0002237 9.71 IL10 CXCL8
19 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.7 TRPV4 IL1B
20 angiotensin maturation GO:0002003 9.7 REN ACE
21 negative regulation of platelet activation GO:0010544 9.69 NOS3 F2
22 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.69 NOS3 ICAM1 HMOX1
23 negative regulation of lipid storage GO:0010888 9.68 TNF CRP
24 multicellular organismal water homeostasis GO:0050891 9.68 TRPV4 CFTR
25 body fluid secretion GO:0007589 9.68 NPPB EDN1
26 response to glucocorticoid GO:0051384 9.68 TNF IL10
27 endothelial cell apoptotic process GO:0072577 9.67 TNF IL10
28 regulation of establishment of endothelial barrier GO:1903140 9.66 TNF IL1B
29 positive regulation of prostaglandin secretion GO:0032308 9.66 IL1B EDN1
30 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.65 NOS3 EDN1
31 positive regulation of neuroinflammatory response GO:0150078 9.64 TNF IL1B
32 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.64 TNF ICAM1
33 negative regulation of cytokine secretion involved in immune response GO:0002740 9.63 TNF IL10
34 positive regulation of fever generation GO:0031622 9.61 TNF IL1B
35 regulation of blood vessel size GO:0050880 9.61 NPPB NOS3 EDN1
36 sequestering of triglyceride GO:0030730 9.59 TNF IL1B
37 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.58 TNF IL1B IL10
38 positive regulation of JUN kinase activity GO:0043507 9.57 TNF EDN1
39 positive regulation of nitric oxide biosynthetic process GO:0045429 9.56 TNF IL1B ICAM1 EDN1
40 receptor biosynthetic process GO:0032800 9.54 TNF IL10
41 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.52 TNF IL1B
42 smooth muscle hyperplasia GO:0014806 9.48 NOS3 HMOX1
43 positive regulation of neutrophil chemotaxis GO:0090023 9.46 EDN1 CXCL8
44 response to lipopolysaccharide GO:0032496 9.43 REN NOS3 IL1B IL10 ICAM1 EDN1
45 response to dexamethasone GO:0071548 9.41 EDN1
46 positive regulation of chemokine biosynthetic process GO:0045080 9.33 TNF IL1B HMOX1
47 response to ozone GO:0010193 9.31 EDN1
48 chronic inflammatory response to antigenic stimulus GO:0002439 9.28 TNF
49 regulation of blood pressure GO:0008217 9.1 REN NPPB NOS3 HMOX1 EDN1 ACE
50 negative regulation of cell proliferation GO:0008285 10.06 NOS3 IL1B IL10 HMOX1 CXCL8

Molecular functions related to Pulmonary Edema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.89 TRPV4 TNNI3 TNF REN NPPB NOS3
2 cytokine activity GO:0005125 9.02 TNF IL1B IL10 EDN1 CXCL8

Sources for Pulmonary Edema

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