MCID: PLM010
MIFTS: 54

Pulmonary Edema

Categories: Cardiovascular diseases, Respiratory diseases

Aliases & Classifications for Pulmonary Edema

MalaCards integrated aliases for Pulmonary Edema:

Name: Pulmonary Edema 12 44 15 17 70

Classifications:



External Ids:

Disease Ontology 12 DOID:11396
MeSH 44 D011654
NCIt 50 C26868
SNOMED-CT 67 19242006
ICD10 32 J81
UMLS 70 C0034063

Summaries for Pulmonary Edema

Disease Ontology : 12 A respiratory failure that is characterized by the accumulation of fluid in the lung tissues causing disturbance of the gas exchange that may lead to respiratory failure.

MalaCards based summary : Pulmonary Edema is related to acute mountain sickness and adult respiratory distress syndrome, and has symptoms including hemoptysis, edema and peau d'orange. An important gene associated with Pulmonary Edema is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are TGF-Beta Pathway and Cytokine Signaling in Immune system. The drugs Dobutamine and Milrinone have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and endothelial, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and Increased viability with MLN4924 (a NAE inhibitor)

Wikipedia : 73 Pulmonary edema is fluid accumulation in the tissue and air spaces of the lungs. It leads to impaired... more...

Related Diseases for Pulmonary Edema

Diseases related to Pulmonary Edema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1078)
# Related Disease Score Top Affiliating Genes
1 acute mountain sickness 33.0 PIK3C2A NOS3 EDN1 AGTR1 ACE
2 adult respiratory distress syndrome 32.6 TNF IL1B IL10 FGF7 F2 CXCL8
3 chronic mountain sickness 32.3 NPPB NOS3 EDN1
4 silicosis 31.8 TNF IL1B IL10 HMOX1 CXCL8 ACE
5 cardiogenic shock 31.5 TNF NPPB
6 pulmonary embolism 31.3 TNNI3 NPPB F2 CRP ACE
7 mitral valve stenosis 31.2 REN NPPB F2 EDN1 CRP ACE
8 intracranial hypertension 31.1 TNF NPPB IL1B F2
9 mitral valve insufficiency 31.1 TNNI3 REN PIK3C2A NPPB F2 CRP
10 eclampsia 31.0 TNF REN NOS3 F2 EDN1 ACE
11 chronic thromboembolic pulmonary hypertension 31.0 NPPB EDN1 CRP
12 pheochromocytoma 31.0 TNF REN KNG1 IL1B EDN1 CRP
13 acute kidney failure 30.9 REN PIK3C2A KNG1 F2
14 glomerulonephritis 30.9 IL1B ICAM1 AGTR1 ACE
15 toxic shock syndrome 30.9 TNF IL1B IL10 CXCL8 CRP
16 pulmonary fibrosis 30.9 IL1B FGF7 EDN1 CXCL8
17 cardiac arrest 30.9 TNNI3 REN PIK3C2A NPPB ACE
18 hemopericardium 30.9 TNNI3 F2 CRP
19 respiratory failure 30.9 TNF REN PIK3C2A NPPB IL1B IL10
20 acute myocardial infarction 30.8 TNNI3 PIK3C2A NPPB EDN1 CRP AGTR1
21 infective endocarditis 30.8 TNNI3 TNF F2 CRP
22 pulmonary hypertension 30.7 TNF REN NPPB NOS3 IL1B HMOX1
23 aspiration pneumonia 30.7 TNF PIK3C2A F2 CRP ACE
24 neutropenia 30.7 TNF IL1B IL10 CXCL8 CRP
25 kidney disease 30.7 TNF REN NPPB NOS3 HMOX1 EDN1
26 disseminated intravascular coagulation 30.7 TNF PIK3C2A IL10 F2 CRP
27 atrial heart septal defect 30.7 TNNI3 NPPB F2 EDN1 CRP ACE
28 orthostatic intolerance 30.7 REN NOS3 EDN1 AGTR1 ACE
29 poliomyelitis 30.7 TNF IL10 ICAM1
30 ischemia 30.7 PIK3C2A NPPB NOS3 KNG1 ICAM1 HMOX1
31 rheumatic heart disease 30.7 TNF NPPB IL1B IL10 ACE
32 aspiration pneumonitis 30.7 TNF CXCL8 CRP
33 acute pancreatitis 30.7 TNF IL1B IL10 CXCL8 CRP
34 plasmodium falciparum malaria 30.7 TNF IL10 ICAM1 CRP
35 rheumatic fever 30.6 TNF NPPB IL10 ICAM1 ACE
36 pneumonia 30.6 TNF PIK3C2A IL1B IL10 HMOX1 CXCL8
37 heart valve disease 30.6 TNNI3 REN NPPB IL1B F2 CRP
38 myocarditis 30.6 TNNI3 TNF PIK3C2A NPPB IL1B IL10
39 brain edema 30.6 KNG1 IL1B HMOX1 CRP AQP5
40 proteinuria, chronic benign 30.6 REN AGTR1 ACE
41 bronchopneumonia 30.6 TNF IL1B IL10 CXCL8 CRP
42 cardiac tamponade 30.6 TNNI3 REN PIK3C2A NPPB F2 CRP
43 uremia 30.6 TNF REN CRP ACE
44 congestive heart failure 30.6 TNNI3 TNF REN PIK3C2A NPPB NOS3
45 atrioventricular block 30.6 TNNI3 PIK3C2A NPPB ACE
46 patent ductus arteriosus 1 30.6 REN NPPB EDN1 CRP ACE
47 diastolic heart failure 30.6 TNNI3 REN NPPB NOS3 AGTR1 ACE
48 fibromuscular dysplasia 30.5 REN AGTR1 ACE
49 hellp syndrome 30.5 IL10 F2 EDN1 CXCL8 CRP
50 intermediate coronary syndrome 30.5 TNNI3 REN PIK3C2A CRP ACE

Graphical network of the top 20 diseases related to Pulmonary Edema:



Diseases related to Pulmonary Edema

Symptoms & Phenotypes for Pulmonary Edema

UMLS symptoms related to Pulmonary Edema:


hemoptysis; edema; peau d'orange

GenomeRNAi Phenotypes related to Pulmonary Edema according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-1 9.65 ACE F2 HMOX1 ICAM1
2 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-2 9.65 ACE F2 HMOX1 IL10 IL1B TNF
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.47 CXCL8 IL10 IL1B REN TNF
4 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.47 ACE CXCL8 HMOX1 ICAM1 IL10 IL1B
5 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 9.47 ICAM1

MGI Mouse Phenotypes related to Pulmonary Edema:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.33 ACE AGTR1 CRP EDN1 F2 HMOX1
2 homeostasis/metabolism MP:0005376 10.33 ACE AGTR1 AQP5 CRP EDN1 F2
3 behavior/neurological MP:0005386 10.32 ACE AGTR1 AQP5 F2 FGF7 HMOX1
4 growth/size/body region MP:0005378 10.31 ACE AGTR1 AQP5 EDN1 F2 FGF7
5 immune system MP:0005387 10.18 ACE AGTR1 CRP F2 FGF7 HMOX1
6 mortality/aging MP:0010768 10.17 ACE AGTR1 AQP5 EDN1 F2 HMOX1
7 muscle MP:0005369 10 AQP5 EDN1 F2 HMOX1 ICAM1 IL10
8 nervous system MP:0003631 9.97 ACE AGTR1 EDN1 F2 FGF7 ICAM1
9 renal/urinary system MP:0005367 9.61 ACE AGTR1 EDN1 FGF7 HMOX1 NOS3
10 respiratory system MP:0005388 9.23 AQP5 F2 HMOX1 IL10 NOS3 TNF

Drugs & Therapeutics for Pulmonary Edema

Drugs for Pulmonary Edema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 95)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dobutamine Approved Phase 4 34368-04-2 36811
2
Milrinone Approved Phase 4 78415-72-2 4197
3
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
4
Morphine Approved, Investigational Phase 4 57-27-2 5288826
5
Acetazolamide Approved, Vet_approved Phase 4 59-66-5 1986
6 Adrenergic beta-Agonists Phase 4
7 Adrenergic Agonists Phase 4
8 Adrenergic Agents Phase 4
9 Phosphodiesterase Inhibitors Phase 4
10 Cardiotonic Agents Phase 4
11 Sympathomimetics Phase 4
12 Protective Agents Phase 4
13 Phosphodiesterase 3 Inhibitors Phase 4
14 Platelet Aggregation Inhibitors Phase 4
15 Neurotransmitter Agents Phase 4
16 Analgesics Phase 4
17 Anesthetics Phase 4
18 Narcotics Phase 4
19 Psychotropic Drugs Phase 4
20 Hypnotics and Sedatives Phase 4
21 GABA Modulators Phase 4
22 Analgesics, Opioid Phase 4
23 Anesthetics, General Phase 4
24 Anesthetics, Intravenous Phase 4
25 Anti-Anxiety Agents Phase 4
26 diuretics Phase 4
27 Anticonvulsants Phase 4
28 Carbonic Anhydrase Inhibitors Phase 4
29
AT-101 Approved, Investigational Phase 3 90141-22-3, 652-67-5 12597
30
Isosorbide Dinitrate Approved, Investigational Phase 3 87-33-2 6883
31
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 3 7487-88-9 24083
32 Tocolytic Agents Phase 3
33 isosorbide-5-mononitrate Phase 3
34 calcium channel blockers Phase 3
35 Calcium, Dietary Phase 3
36 Anti-Arrhythmia Agents Phase 3
37
Calcium Nutraceutical Phase 3 7440-70-2 271
38
Dexamethasone Approved, Investigational, Vet_approved Phase 1, Phase 2 50-02-2 5743
39
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1, Phase 2 1177-87-3
40
Tadalafil Approved, Investigational Phase 1, Phase 2 171596-29-5 110635
41
Furosemide Approved, Vet_approved Phase 2 54-31-9 3440
42
Glycerol Approved, Investigational Phase 2 56-81-5 753
43
Nitroglycerin Approved, Investigational Phase 2 55-63-0 4510
44
Sodium citrate Approved, Investigational Phase 2 68-04-2
45
Vitamin A Approved, Nutraceutical, Vet_approved Phase 2 68-26-8, 11103-57-4 445354
46
Citric acid Approved, Nutraceutical, Vet_approved Phase 2 77-92-9 311
47 Respiratory System Agents Phase 2
48 Anti-Asthmatic Agents Phase 2
49 Bronchodilator Agents Phase 2
50 Anti-Inflammatory Agents Phase 1, Phase 2

Interventional clinical trials:

(show top 50) (show all 121)
# Name Status NCT ID Phase Drugs
1 Impact of Fluid Resuscitation Therapy on Pulmonary Edema as Measured by Alveolar Fluid Clearance in Patients With Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT01763853 Phase 4 4% albumin
2 Non-Invasive Positive Pressure Mask Ventilation vs Extrathoracic Biphasic Cuirass Ventilation in Patients With Acute Respiratory Failure: A Randomized Prospective Study. Unknown status NCT00331656 Phase 4
3 Non Invasive Positive Airway Pressure And Risk Of Myocardial Infarction In Acute Cardiogenic Pulmonary Edema: Continuous Positive Airway Pressure Vs Non Invasive Positive Pressure Ventilation Completed NCT00453947 Phase 4
4 Randomised Controlled Comparison of Continuous Positive Airway Pressure (CPAP) With Standard Treatment in Out-of-hospital Patients With Acute Cardiogenic Pulmonary Edema. Completed NCT00439075 Phase 4 standard treatment
5 Continuous Positive Airway Pressure Versus Non-Invasive Positive Pressure Support Ventilation in Acute Cardiogenic Pulmonary Oedema: a Prospective Randomised Multicentre Trial. Completed NCT00446498 Phase 4
6 Randomized, Controlled Trial of Regular Sildenafil Citrate in the Prevention of Altitude Illness Completed NCT00627965 Phase 4 Sildenafil citrate;Placebo
7 CPAP Versus BiPAP in Acute Cardiogenic Pulmonary Edema: Experience With 129 Patients Completed NCT00912158 Phase 4
8 Comparison of Milrinone Versus Dobutamine in a Heterogeneous Population of Critically Ill Patients Completed NCT03207165 Phase 4 Milrinone;Dobutamine
9 Study Design and Rationale of "A Multicenter, Open-Labeled, Randomized Controlled Trial Comparing MIdazolam Versus MOrphine in Acute Pulmonary Edema": MIMO Trial Recruiting NCT02856698 Phase 4 Midazolam;Morphine
10 Impact of Obstructive Sleep Apnea Treatment on Cardiovascular Events in Patients With Acute Cardiogenic Pulmonary Edema: a Multicenter Randomized Controlled Study (CPAP-CARE STUDY). Recruiting NCT03936751 Phase 4
11 A Prospective, Double-blind, Randomized, Placebo-controlled Trial of Acetazolamide on Subclinical High-Altitude Pulmonary Edema Detected by Lung Ultrasonography Terminated NCT03490916 Phase 4 Acetazolamide;Placebo
12 Double Blind Randomized Placebo Controlled Trial of Natrecor in Patients Hospitalized for Decompensated Heart Failure in the Presence of a Normal Left Ventricular Ejection Fraction Withdrawn NCT00505791 Phase 4 Nesiritide
13 Effect of Continuous Positive Airway Pressure as a First Line Therapy in Out-of-Hospital Management of Severe Cardiogenic Pulmonary Edema Completed NCT00390442 Phase 3
14 CPAP Boussignac Versus Bilevel Pressure Support Ventilation in Severe Acute Cardiogenic Pulmonary Edema Completed NCT00213681 Phase 3
15 Effect of Continuous Positive Airway Pressure on Short Term Inhospital Prognosis for Acute Pulmonary Edema Completed NCT00554580 Phase 3
16 Non-Invasive Ventilation Versus Continuous Positive Airway Pressure in Cardiogenic Pulmonary Edema: a Multicentre Study Completed NCT00785174 Phase 3
17 Randomized Clinical Trial of the Beneficial Effects of Antenatal Magnesium Sulfate (BEAM) Completed NCT00014989 Phase 3 magnesium sulfate
18 Impact on Mortality of the Timing of Renal Replacement Therapy in Patients With Severe Acute Kidney Injury in Septic Shock: the IDEAL-ICU Study (Initiation of Dialysis Early Versus Delayed in the Intensive Care Unit): Study Protocol for a Randomized Controlled Trial Terminated NCT01682590 Phase 3
19 The Effect of Nebulized Albuterol on Donor Oxygenation Completed NCT00310401 Phase 2 Albuterol;Saline
20 A Randomized Controlled Trial of the Effects of Tadalafil and Dexamethasone Versus Placebo on Pulmonary Edema Formation and Cerebral Blood Flow Autoregulation in High Altitude Newcomers With a Previous History of High Altitude Pulmonary Edema Completed NCT00274430 Phase 1, Phase 2 dexamethasone 8 mg bid;tadalafil 10mg bid
21 The Evaluation of the Effect of Sodium Bicarbonate Solution in Decreasing the Incidence of Contrast Induced Nephropathy (CIN) in Patients With Pulmonary Edema,Severe Heart Failure or Uncontrolled Hypertension Completed NCT00513825 Phase 2 Sodium Bicarbonate
22 A Pilot Study Of ALT-711 In Elderly Patients With Isolated Diastolic Heart Failure: The DIAMOND Study Completed NCT00043836 Phase 2 ALT-711
23 B-lines Lung Ultrasound Guided ED Management of Acute Heart Failure Pilot Trial Completed NCT03136198 Phase 2 Intravenous Loop Diuretic;Vasodilator
24 A Sponsor Un-blinded, Placebo-controlled Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single and Repeat, Ascending Doses of GSK2798745 in Healthy Subjects and Stable Heart Failure Patients Completed NCT02119260 Phase 2 GSK2798745 solution;GSK2798745 suspension;GSK2798745 capsule;Placebo solution;Placebo suspension;Placebo capsule
25 A Randomised, Double-blind, Placebo-controlled Study to Investigate the Safety and Efficacy of Intravenous Imatinib Mesylate (Impentri®) in Subjects With Acute Respiratory Distress Syndrome Induced by COVID-19 Recruiting NCT04794088 Phase 2 Imatinib Mesylate intravenous solution;Placebo
26 Nitroglycerin vs. Furosemide Using Lung Ultrasound Pilot Trial (N-FURIOUS) Recruiting NCT03259165 Phase 2 Nitrates;Loop Diuretics
27 Phase II Randomized, Intervention Versus Non-Intervention, Multi-center Study of the Effects of Thyroid Hormone (T3) on Extravascular Lung Water (EVLW) in Subjects With Acute Respiratory Distress Syndrome (ARDS) Recruiting NCT04115514 Phase 1, Phase 2 Liothyronine Sodium (T3) (modified formulation)
28 Sildenafil for Prevention of Swimming-Induced Pulmonary Edema (SIPE) Enrolling by invitation NCT03686813 Phase 2 Sildenafil Citrate;Placebo Oral Tablet
29 A Randomized, Double-Blind, Parallel Group Study to Assess the Efficacy and Safety of Once Weekly Subcutaneous Injections of Pemziviptadil (PB1046), a Sustained-Release VIP (Vasoactive Intestinal Peptide) ANalogue, in Hospitalized COVID-19 Patients at HiGh Risk for Rapid Clinical Deterioration and ARDS (PB1046 VANGARD Study) Terminated NCT04433546 Phase 2 Pemziviptadil (PB1046);Low Dose (10 mg) Control
30 An Evaluation of MRI Measures of Lung Water Increases With Postural Changes in Healthy Subjects and in Patients With Cardiac Failure: A Methods Validation Study for Evaluation of Novel Treatments Limiting Pulmonary Oedema in Cardiac Failure Completed NCT01277679 Phase 1
31 Hypoxia Impairs Systemic Endothelial Function in Individuals Prone to High-Altitude Pulmonary Edema. Completed NCT00176007 Phase 1
32 An Evaluation of DCE-MRI Measures of Pulmonary Oedema and Vascular Permeability in Healthy Subjects and in Patients With Cardiac Failure: A Methods Validation Study for Evaluation of Novel Treatments Limiting Pulmonary Oedema in Cardiac Failure Completed NCT02135861 Phase 1
33 Inhaled Hypertonic Saline for the Treatment of Acute Lung Injury Withdrawn NCT01713595 Phase 1 Hypertonic Saline Aerosol
34 Power Spectral Analysis of Lung Sounds Detected at Bilateral Lung Bases in Patients With Cardiogenic and Non-cardiogenic Pulmonary Edema Unknown status NCT00767195
35 Daily Lung Ultrasound Assisting Weaning From Mechanical Ventilation in Difficult-to-wean Adult Patients - a Randomized Trial. Unknown status NCT01724034
36 Perioperative Myocardial Ischemia: Implementation of Troponin Monitoring, Economic Analysis and Further Insights Into Pathophysiology Unknown status NCT03438448
37 Evaluation of the Effectiveness of Non-invasive Ventilation on the Reperfusion Pulmonary Oedema Post Pulmonary Artery Angioplasty in the Post Embolic Pulmonary Hypertension Unknown status NCT02548091
38 Mortality and Risk Factors in Patients With Acute Cardiogenic Pulmonary Edema: a Multicentric, Observational, Prospective Study Unknown status NCT01269177
39 High Flow Nasal Oxygen Versus VNI for Emergency Department Treatment of Acute Hypercapnic Cardiogenic Pulmonary Edema With Respiratory Failure: a Multicenter Randomized Non Inferiority Trial Unknown status NCT02874339
40 The Practice of Fluid Management in the Post-anesthetic Care Unit (PACU) in Patients Undergoing Elective Surgery: an Observational Study Unknown status NCT00995228
41 Electrical Impedance Tomography for Quantification of Pulmonary Edema in Acute Respiratory Distress Syndrome Patients Unknown status NCT02870894
42 Non-Invasive Pulmonary Monitoring in Patients With Cardiogenic Pulmonary Congestion and Edema Unknown status NCT01885403
43 Training Thoracic Ultrasound Skills: a Multicentre, Blinded, Randomized Controlled Trial of Simulation-based Training Versus Training on Healthy Figurants Unknown status NCT03728491
44 Registry Of Acute meDical Emergencies in Brazil - ROAD-Brazil Unknown status NCT02753023
45 Early Left Atrial Venting Versus Conventional Treatment For Left Ventricular Decompression During Venoarterial Extracorporeal Membrane Oxygenation Support Unknown status NCT03740711
46 Intolerance Mechanisms and Exercise Performance Limitation During a High Altitude Stay: Investigation of Sleep and Cerebral Responses Unknown status NCT01565603
47 Rule of Carbone Monoxyde in the Ex Vivo Lung Perfusion Reconditionning Unknown status NCT02032082
48 Intra-operative Inspiratory Oxygen Fraction and Postoperative Respiratory Complications Unknown status NCT02399878 Inspiratory oxygen
49 Hemodynamic Changes in Altitude Adaptation Unknown status NCT01698619
50 The Role of CARdiovascular biOmarkers (NT-pro-BNP and CD146) in Predicting Lung Edema in Severely Burned Patients Unknown status NCT03271268

Search NIH Clinical Center for Pulmonary Edema

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Bumetanide
Ethacrynate Sodium
Ethacrynic Acid
Furosemide
Mannitol hexanitrate
torsemide

Cochrane evidence based reviews: pulmonary edema

Genetic Tests for Pulmonary Edema

Anatomical Context for Pulmonary Edema

MalaCards organs/tissues related to Pulmonary Edema:

40
Heart, Lung, Endothelial, Kidney, Liver, Brain, Neutrophil

Publications for Pulmonary Edema

Articles related to Pulmonary Edema:

(show top 50) (show all 15062)
# Title Authors PMID Year
1
Acute Mountain Sickness, High Altitude Pulmonary Edema, and High Altitude Cerebral Edema: A view from the High Andes. 61
33545376 2021
2
RBM3 Increases Cell Survival but Disrupts Tight Junction of Microvascular Endothelial Cells in Acute Lung Injury. 61
33460967 2021
3
Effects of Lung Ultrasonography-Guided Management on Cumulative Fluid Balance and Other Clinical Outcomes: A Systematic Review. 61
33637390 2021
4
Renal venous congestion following hemorrhagic shock due to traumatic liver injury. 61
33038002 2021
5
Sodium-coupled neutral amino acid transporter SNAT2 counteracts cardiogenic pulmonary edema by driving alveolar fluid clearance. 61
33439101 2021
6
Continuous positive airway pressure therapy in the management of hypercapnic cardiogenic pulmonary edema. 61
33794591 2021
7
Ultra-high dose intravenous nitroglycerin in an ESRD patient with acutely decompensated heart failure. 61
33718922 2021
8
Diammonium glycyrrhizinate lipid ligand ameliorates lipopolysaccharide-induced acute lung injury by modulating vascular endothelial barrier function. 61
33717246 2021
9
Significance of Lung Weight in Cellular Ex Vivo Lung Perfusion. 61
33348170 2021
10
The receptor for advanced glycation end products mediates dysfunction of airway epithelial barrier in a lipopolysaccharides-induced murine acute lung injury model. 61
33548580 2021
11
The Significance of Subpleural Sparing in CT Chest: A State-of-the-Art Review. 61
33487401 2021
12
Outcomes of left ventricular unloading with a transseptal cannula during extracorporeal membrane oxygenation in adults. 61
33001468 2021
13
Embryo-toxicity of docosahexaenoic and eicosapentaenoic acids: In vivo and in silico investigations using the chick embryo model. 61
33450494 2021
14
Randomized, Placebo-controlled Trial of Inhaled Treprostinil for Patients at Risk for Acute Respiratory Distress Syndrome. 61
33095030 2021
15
PDE3-inhibitor enoximone prevented mechanical ventilation in patients with SARS-CoV-2 pneumonia. 61
33544007 2021
16
Nonischemic Dilated Cardiomyopathy in Untreated Long-Term Psoriatic Arthritis: A Newly Recognized Association: A Case Report with Mini Review. 61
33795630 2021
17
Evaluation of bronchial narrowing in coughing dogs with heart murmurs using computed tomography. 61
33811698 2021
18
The many faces and outcomes of pulmonary vein stenosis in early childhood. 61
32506838 2021
19
Death due to consumption of ibogaine: case report. 61
33433774 2021
20
Coronavirus disease 2019 and dengue: two case reports. 61
33771221 2021
21
Henoch-Schönlein Purpura Associated With Diffuse Large B-cell Lymphoma of the Orbit. 61
32675722 2021
22
Outcomes of Patients Treated with Prehospital Noninvasive Ventilation: Observational Retrospective Multicenter Study in the Northern French Alps. 61
33806188 2021
23
Sudden Death Due to Severe Ovarian Hyperstimulation Syndrome: An Autopsy-Centric Case Report. 61
33186129 2021
24
Mechanical Complications of Acute Myocardial Infarction: A Review. 61
33295949 2021
25
Effects of morphine on P2Y12 platelet inhibitors in patients with acute myocardial infarction: A meta-analysis. 61
33317866 2021
26
Naloxone-Induced Acute Pulmonary Edema is Dose-Dependent: A Case Series. 61
33730013 2021
27
Intravenous furosemide vs nebulized furosemide in patients with pulmonary edema: A randomized controlled trial. 61
33490638 2021
28
[Flash pulmonary edema in a geriatric patient after the placement of a pacemaker: Clinical case and literature review]. 61
33775431 2021
29
Flash Pulmonary Edema in a 70-Year-Old Man. 61
33779270 2021
30
Application of α2 -adrenergic agonists combined with anesthetics and their implication in pulmonary intravascular macrophages-insulted pulmonary edema and hypoxemia in ruminants. 61
33709435 2021
31
Small Immunomodulatory Molecules as Potential Therapeutics in Experimental Murine Models of Acute Lung Injury (ALI)/Acute Respiratory Distress Syndrome (ARDS). 61
33806560 2021
32
BMSC-derived exosomes ameliorate sulfur mustard-induced acute lung injury by regulating the GPRC5A-YAP axis. 61
33654219 2021
33
MicroRNA-877-5p alleviates ARDS via enhancing PI3K/Akt path by targeting CDKN1B both in vivo and in vitro. 61
33735715 2021
34
α1-Antitrypsin. 61
33721888 2021
35
Standardization of Methods for Sampling the Distal Airspace in Mechanically Ventilated Patients using Heat Moisture Exchange Filter Fluid. 61
33655765 2021
36
Development of a convolutional neural network to differentiate among the etiology of similar appearing pathological B lines on lung ultrasound: a deep learning study. 61
33674378 2021
37
Panaxydol attenuates ferroptosis against LPS-induced acute lung injury in mice by Keap1-Nrf2/HO-1 pathway. 61
33653364 2021
38
A role for bronchial epithelial autotaxin in ventilator-induced lung injury. 61
33778909 2021
39
Systematic Review of Negative Pressure Pulmonary Edema in Otolaryngology Procedures. 61
32627567 2021
40
Additional Discussion from Anesthesiologists: Preventive Strategy for Reexpansion Pulmonary Edema after Minimally Invasive Cardiac Surgery. 61
33705776 2021
41
Diagnostic accuracy of ultra-low-dose chest computed tomography in an emergency department. 61
33663246 2021
42
Aldosterone alleviates lipopolysaccharide-induced acute lung injury by regulating epithelial sodium channel through PI3K/Akt/SGK1 signaling pathway. 61
33713776 2021
43
Monocytes promote pyroptosis of endothelial cells during lung ischemia-reperfusion via IL-1R/NF-κB/NLRP3 signaling. 61
33785335 2021
44
Utility of transesophageal echocardiography to assess real time left atrial pressure changes and dynamic mitral regurgitation following placement of transseptal multistage venous cannula for systemic venous drainage and indirect left ventricular venting in venoarterial extracorporeal membrane oxygenation. 61
33619808 2021
45
Point-of-Care Lung Ultrasound Pattern in Healthy Parturients: Prevalence of Pulmonary Interstitial Syndrome Following Vaginal Delivery, Elective and Unplanned Intrapartum Cesarean Delivery. 61
33721873 2021
46
Identification of a Human Whole Blood-Based Endothelial Cell Impedance Assay for Assessing Clinical Transient Receptor Potential Vanilloid 4 Target Engagement Ex Vivo. 61
33376150 2021
47
[Treatment of renal artery stenosis in the year 2021]. 61
33459806 2021
48
Inhibition of complement C5a receptor protects lung cells and tissues against lipopolysaccharide-induced injury via blocking pyroptosis. 61
33714207 2021
49
Point-of-Care Ultrasound Diagnosis of Acute High Altitude Illness: A Case Report. 61
33744108 2021
50
Mutations during the adaptation of H7N9 avian influenza virus to mice lungs enhance human-like sialic acid binding activity and virulence in mice. 61
33515926 2021

Variations for Pulmonary Edema

Expression for Pulmonary Edema

Search GEO for disease gene expression data for Pulmonary Edema.

Pathways for Pulmonary Edema

Pathways related to Pulmonary Edema according to GeneCards Suite gene sharing:

(show all 44)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.53 TNF IL1B IL10 ICAM1 FGF7 F2
2
Show member pathways
13.34 TNF IL1B IL10 ICAM1 HMOX1 FGF7
3
Show member pathways
13.33 TNNI3 TNF REN NPPB NOS3 IL1B
4
Show member pathways
13.16 TNF NOS3 KNG1 IL1B IL10 ICAM1
5
Show member pathways
12.85 TNF IL1B IL10 ICAM1 CXCL8 AGTR1
6 12.76 KNG1 HMOX1 FGF7 F2 EDN1 CXCL8
7
Show member pathways
12.72 TNF PIK3C2A IL1B F2 CXCL8
8
Show member pathways
12.7 TNF IL1B HMOX1 EDN1 CXCL8
9
Show member pathways
12.64 TRPV4 NPPB KNG1 IL1B EDN1
10
Show member pathways
12.55 TNNI3 NPPB NOS3 KNG1 AGTR1
11
Show member pathways
12.53 TNF NOS3 IL1B IL10 F2 AGTR1
12
Show member pathways
12.31 TNF IL1B ICAM1 F2 CRP
13
Show member pathways
12.26 TNF IL1B IL10 FGF7 CXCL8
14
Show member pathways
12.24 TNNI3 TNF EDN1 ACE
15 12.17 TNF IL1B IL10 CXCL8
16 12.08 TNF IL1B IL10 CXCL8
17 12.01 TNF IL1B ICAM1 CXCL8
18 11.97 TNF IL1B ICAM1 EDN1
19 11.93 TNF IL1B ICAM1 CXCL8
20 11.91 TNF IL1B IL10 CXCL8
21 11.86 TNF IL1B ICAM1 CXCL8
22 11.86 TNF IL1B IL10 ICAM1 HMOX1 CXCL8
23 11.84 TRPV4 TNF NOS3 IL1B ICAM1 HMOX1
24 11.77 TNF IL1B IL10
25 11.76 TNF IL1B IL10 CXCL8
26
Show member pathways
11.76 REN NOS3 KNG1 AGTR1 ACE
27
Show member pathways
11.74 TNF IL1B IL10
28 11.73 TNF IL1B IL10
29 11.68 REN EDN1 AGTR1 ACE
30 11.67 TNF IL10 ICAM1
31
Show member pathways
11.61 TNF IL1B ICAM1 CXCL8
32 11.6 TNF IL1B CXCL8
33 11.52 TNF KNG1 ICAM1
34 11.5 TNF IL1B IL10 ICAM1 CXCL8
35 11.46 TNF IL1B IL10 ICAM1 CXCL8
36 11.35 NOS3 HMOX1 CXCL8
37 11.32 TNF IL1B IL10 HMOX1
38 11.26 TNF IL1B IL10
39 11.23 TNF IL1B HMOX1 FGF7 EDN1 CXCL8
40 11.22 TNF KNG1 IL1B IL10 ICAM1
41 11.17 IL1B ICAM1 F2
42 11.17 TNF NOS3 IL1B ICAM1 EDN1 CXCL8
43 11.01 TNF HMOX1 CXCL8 CRP
44 10.94 TNF IL1B ICAM1

GO Terms for Pulmonary Edema

Cellular components related to Pulmonary Edema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 TNF REN NPPB KNG1 IL1B IL10
2 extracellular space GO:0005615 9.47 TNF REN NPPB KNG1 IL1B IL10

Biological processes related to Pulmonary Edema according to GeneCards Suite gene sharing:

(show all 41)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 10.07 NOS3 IL1B IL10 HMOX1 CXCL8
2 response to drug GO:0042493 9.97 REN IL10 ICAM1 HMOX1 EDN1
3 positive regulation of protein phosphorylation GO:0001934 9.95 TNF IL1B FGF7 F2
4 inflammatory response GO:0006954 9.93 TNF KNG1 IL1B CXCL8 CRP AGTR1
5 positive regulation of cytosolic calcium ion concentration GO:0007204 9.91 TRPV4 KNG1 EDN1 AGTR1
6 positive regulation of angiogenesis GO:0045766 9.9 NOS3 IL1B HMOX1 CXCL8
7 positive regulation of gene expression GO:0010628 9.87 TRPV4 TNF NOS3 IL1B FGF7 CXCL8
8 response to insulin GO:0032868 9.86 TRPV4 IL10 ICAM1
9 cytokine-mediated signaling pathway GO:0019221 9.85 TNF IL1B IL10 ICAM1 HMOX1 CXCL8
10 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.84 TNF IL1B EDN1
11 cellular response to drug GO:0035690 9.84 REN IL1B EDN1
12 positive regulation of DNA-binding transcription factor activity GO:0051091 9.84 TNF IL1B IL10 EDN1
13 positive regulation of smooth muscle cell proliferation GO:0048661 9.82 TNF HMOX1 EDN1
14 positive regulation of inflammatory response GO:0050729 9.8 TRPV4 TNF IL1B AGTR1
15 cellular response to lipopolysaccharide GO:0071222 9.8 TNF IL1B IL10 ICAM1 CXCL8
16 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.79 TNF IL10 EDN1
17 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.75 NOS3 ICAM1 HMOX1
18 positive regulation of JAK-STAT cascade GO:0046427 9.72 TNF IL10 F2
19 regulation of establishment of endothelial barrier GO:1903140 9.68 TNF IL1B
20 positive regulation of prostaglandin secretion GO:0032308 9.68 IL1B EDN1
21 negative regulation of lipid storage GO:0010888 9.68 TNF CRP
22 negative regulation of platelet activation GO:0010544 9.67 NOS3 F2
23 endothelial cell apoptotic process GO:0072577 9.66 TNF IL10
24 cellular hypotonic response GO:0071476 9.65 TRPV4 AQP5
25 body fluid secretion GO:0007589 9.65 NPPB EDN1
26 regulation of vasoconstriction GO:0019229 9.65 EDN1 AGTR1 ACE
27 vascular endothelial growth factor production GO:0010573 9.64 TNF IL1B
28 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.63 NOS3 EDN1
29 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.63 AGTR1 ACE
30 negative regulation of cytokine production involved in immune response GO:0002719 9.62 TNF IL10
31 positive regulation of fever generation GO:0031622 9.61 TNF IL1B
32 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.61 TNF IL1B IL10
33 sequestering of triglyceride GO:0030730 9.59 TNF IL1B
34 renin-angiotensin regulation of aldosterone production GO:0002018 9.58 REN AGTR1
35 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.56 TNF IL1B
36 positive regulation of nitric oxide biosynthetic process GO:0045429 9.56 TNF IL1B ICAM1 EDN1
37 negative regulation of gap junction assembly GO:1903597 9.52 IL1B ACE
38 smooth muscle hyperplasia GO:0014806 9.51 NOS3 HMOX1
39 regulation of blood vessel diameter GO:0097746 9.46 NPPB NOS3 AGTR1 ACE
40 response to lipopolysaccharide GO:0032496 9.43 REN NOS3 IL1B IL10 ICAM1 EDN1
41 regulation of blood pressure GO:0008217 9.1 REN NPPB NOS3 HMOX1 EDN1 ACE

Molecular functions related to Pulmonary Edema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.55 REN NPPB KNG1 F2 EDN1
2 cytokine activity GO:0005125 9.02 TNF IL1B IL10 EDN1 CXCL8
3 bradykinin receptor binding GO:0031711 8.96 AGTR1 ACE

Sources for Pulmonary Edema

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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